nifedipine has been researched along with Chemical and Drug Induced Liver Injury in 22 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we present a case of nifedipine-induced hepatitis in a 78-year-old Caucasian female with no prior history of liver or autoimmune disease." | 7.88 | A case report of nifedipine-induced hepatitis with jaundice. ( Christy, J; Fishman, MJ; Ho, M; Li, D; Owen, D; Yusuf, D, 2018) |
| "Alpha-methyldopa is a regularly used antihypertensive drug during pregnancy." | 7.76 | [Methyldopa-induced acute reactive hepatitis in pregnancy, drug-metabolizing capacity of the liver]. ( Monostory, K; Ozsvár, Z; Solymossi, Z, 2010) |
| "Here we present a case of nifedipine-induced hepatitis in a 78-year-old Caucasian female with no prior history of liver or autoimmune disease." | 3.88 | A case report of nifedipine-induced hepatitis with jaundice. ( Christy, J; Fishman, MJ; Ho, M; Li, D; Owen, D; Yusuf, D, 2018) |
| "Alpha-methyldopa is a regularly used antihypertensive drug during pregnancy." | 3.76 | [Methyldopa-induced acute reactive hepatitis in pregnancy, drug-metabolizing capacity of the liver]. ( Monostory, K; Ozsvár, Z; Solymossi, Z, 2010) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "The aim of the present work was to clarify the involvement of free radicals, cytochrome P450 toxic metabolites, and deregulation of calcium homeostasis in the mechanism of diethyldithiocarbamate (DDC) hepatotoxicity." | 1.37 | The protective effects of ascorbic acid, cimetidine, and nifedipine on diethyldithiocarbamate-induced hepatic toxicity in albino rats. ( Badawy, MM; Gaafa, KM; Hamza, AA, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Pretreatment of galactosamine/TNF-alpha-injured mice with 800 mg/kg uridine or with 6 mg/kg calmidazolium fully protected the animals, while administration of either verapamil or nifedipine (100 mg/kg, respectively) had no significant effect." | 1.28 | Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. ( Tiegs, G; Wendel, A; Wolter, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (27.27) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 14 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Yusuf, D | 1 |
| Christy, J | 1 |
| Owen, D | 1 |
| Ho, M | 1 |
| Li, D | 1 |
| Fishman, MJ | 1 |
| Ozsvár, Z | 1 |
| Solymossi, Z | 1 |
| Monostory, K | 1 |
| Gaafa, KM | 1 |
| Badawy, MM | 1 |
| Hamza, AA | 1 |
| Boelsterli, UA | 1 |
| Ho, HK | 1 |
| Zhou, S | 1 |
| Leow, KY | 1 |
| Rotmensch, HH | 1 |
| Weintraub, M | 1 |
| Sofferman, G | 1 |
| Livni, E | 1 |
| Klejman, A | 1 |
| Liron, M | 1 |
| Davidson, AR | 1 |
| Deakin, CD | 1 |
| Gove, CD | 1 |
| Fagan, EA | 1 |
| Tredger, JM | 1 |
| Williams, R | 1 |
| Tiegs, G | 1 |
| Wolter, M | 1 |
| Wendel, A | 1 |
| Babany, G | 1 |
| Uzzan, F | 1 |
| Larrey, D | 1 |
| Degott, C | 1 |
| Bourgeois, P | 1 |
| René, E | 1 |
| Vissuzaine, C | 1 |
| Erlinger, S | 1 |
| Benhamou, JP | 1 |
| Shaw, DR | 1 |
| Misan, GM | 1 |
| Johnson, RD | 1 |
| Abramson, M | 1 |
| Littlejohn, GO | 1 |
2 reviews available for nifedipine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Bioactivation and hepatotoxicity of nitroaromatic drugs.
Topics: Benzophenones; Biotransformation; Chemical and Drug Induced Liver Injury; Flutamide; Imidazolidines; | 2006 |
20 other studies available for nifedipine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
A case report of nifedipine-induced hepatitis with jaundice.
Topics: Aged; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Female; Hepatitis; Humans; J | 2018 |
[Methyldopa-induced acute reactive hepatitis in pregnancy, drug-metabolizing capacity of the liver].
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Blood Pres | 2010 |
The protective effects of ascorbic acid, cimetidine, and nifedipine on diethyldithiocarbamate-induced hepatic toxicity in albino rats.
Topics: Animals; Ascorbic Acid; Biomarkers; Calcium; Chemical and Drug Induced Liver Injury; Cimetidine; Cyt | 2011 |
Experience with immunological tests in drug-induced hepatitis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Fluorescent Antibody Te | 1981 |
Lymphocyte sensitisation in nifedipine-induced hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Liver Diseases, Alcoholic; Ma | 1980 |
Delayed calcium channel blockade with diltiazem reduces paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diltiaz | 1991 |
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice.
Topics: Allopurinol; Animals; Chemical and Drug Induced Liver Injury; Eicosanoic Acids; Endotoxins; Epoprost | 1989 |
Alcoholic-like liver lesions induced by nifedipine.
Topics: Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepatitis, Alcoholic; | 1989 |
Nifedipine hepatitis.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Biopsy; Chemical and Drug Induced Liver Injury; Female; Hu | 1987 |
Hepatic reactions to nifedipine.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Liver Function Tests; M | 1985 |