nifedipine has been researched along with Cerebral Ischemia in 56 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the neuroprotective effects of benidipine hydrochloride on the cerebral cortex tissues in rats exposed to cerebral ischemia-reperfusion (I/R) injury." | 8.02 | Effects of Benidipine Hydrochloride on Ischemia Reperfusion Injury of Rat Brain. ( Arslan, YK; Cakir, T; Suleyman, H; Sunar, M; Yazici, GN; Yucetas, SC, 2021) |
| "We investigated the effects of nilvadipine and amlodipine on the cerebral ischemia-induced impairment of spatial memory in 8-arm radial maze performance and hippocampal CA1 apoptosis in rats." | 7.72 | Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats. ( Al-Khatib, IH; Egashira, N; Egawa, T; Fujiwara, M; Irie, K; Ishibashi, D; Iwasaki, K; Kobayashi, H; Mishima, K, 2003) |
| "The protective effect of nilvadipine, a Ca2+ antagonist, on cerebral ischemia was investigated in spontaneously hypertensive rats." | 7.69 | Protective effect of nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats. ( Fukasawa, H; Kawamura, S; Li, Y; Shirasawa, M; Yasui, N, 1996) |
| "The purpose of the present study was to examine the effect of nilvadipine (a dihydropyridine-type calcium entry blocker) on the cerebral circulation, experimental models of cerebral ischemia were used to measure abrupt changes in the cortical cerebral blood flow (CBF) at the 'penumbra' (the boundary region between the anterior cerebral artery (ACA) and the middle cerebral artery (MCA))." | 7.69 | Effects of nilvadipine (a dihydropyridine-type calcium entry blocker) on cerebral blood flow in acute experimental brain ischemia in rats. ( Fujii, K; Maruyama, S; Miyasaka, Y; Nagai, S; Tanaka, R, 1996) |
| "The effects of nilvadipine, a Ca2+ entry blocker, on focal cerebral ischemia were investigated in rats having unilateral middle cerebral artery occlusion." | 7.68 | Effects of a Ca2+ entry blocker (nilvadipine) on acute focal cerebral ischemia in rats. ( Fukasawa, H; Kawamura, S; Shirasawa, M; Yasui, N, 1991) |
| "We studied the efficacy of preischemic and postischemic systemic treatment with a new calcium antagonist nilvadipine in a permanent focal cerebral ischemia model of spontaneously hypertensive rats." | 7.68 | Effects of the calcium antagonist nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats. ( Handa, J; Matsuda, M; Shiino, A; Susumu, T, 1991) |
| "The effects of two dihydropyridine type calcium entry blockers, nilvadipine and nicardipine hydrochloride (nicardipine), on the liberation of free fatty acids (FFAs) were investigated using an experimental model of global cerebral ischemia in rats, and were compared with their pharmacokinetic properties." | 7.68 | Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride. ( Fujiwara, T; Kohsaka, M; Mori, J; Satoh, H; Sogabe, K; Takakura, S; Tokuma, Y; Totsuka, Z, 1992) |
| "The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries." | 7.68 | Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats. ( Karasawa, A; Kubo, K; Shirakura, S, 1993) |
| " Oral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for women presenting with pre-eclampsia." | 4.98 | Focused Update on Pharmacologic Management of Hypertensive Emergencies. ( Broscious, R; Devabhakthuni, S; Noel, ZR; Watson, K, 2018) |
| "To evaluate the neuroprotective effects of benidipine hydrochloride on the cerebral cortex tissues in rats exposed to cerebral ischemia-reperfusion (I/R) injury." | 4.02 | Effects of Benidipine Hydrochloride on Ischemia Reperfusion Injury of Rat Brain. ( Arslan, YK; Cakir, T; Suleyman, H; Sunar, M; Yazici, GN; Yucetas, SC, 2021) |
| "In patients with hypertension and dementia, nifedipine was associated with increased mortality risk (aHR 1." | 4.02 | Calcium channel blockers, survival and ischaemic stroke in patients with dementia: a Swedish registry study. ( Eriksdotter, M; Garcia-Ptacek, S; Kalar, I; Kramberger, MG; Schwertner, E; Secnik, J; von Euler, M; Winblad, B; Xu, H, 2021) |
| " This study investigated the effects of nifedipine, an L-type voltage-gated Ca(2+) channel blocker, on ischemic lesion volume after focal cerebral ischemia and reperfusion in rats." | 3.77 | Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects. ( Honda, Y; Ide, T; Shiba, T; Tsutsui, H; Yamada, K; Yamato, M, 2011) |
| "We investigated the effects of nilvadipine and amlodipine on the cerebral ischemia-induced impairment of spatial memory in 8-arm radial maze performance and hippocampal CA1 apoptosis in rats." | 3.72 | Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats. ( Al-Khatib, IH; Egashira, N; Egawa, T; Fujiwara, M; Irie, K; Ishibashi, D; Iwasaki, K; Kobayashi, H; Mishima, K, 2003) |
| "The effects of three drugs including ketamine(KT), a noncompetitive antagonist of NMDA receptor (NR), nifedipine(ND), a voltage gated calcium channel (VGCC) antagonist and 6, 7dinitroquinoxaline -2, 3-dione(DNQX), a non-NMDA receptor antagonist on the contents of phospho-tyrosine proteins (p-tyr-pr) in the synaptosomal(P2), the crude membrane (P3), and the cytosolic (S3) fractions of hippocampus in forebrain ischemia of mongolian gerbils were studied." | 3.71 | [Effects of ischemia/reperfusion on the phosphotyrosine proteins contents in hippocampus]. ( Gui, ZH; Li, Y; Pei, L; Zhang, GY; Zhu, ZM, 2001) |
| "The purpose of the present study was to examine the effect of nilvadipine (a dihydropyridine-type calcium entry blocker) on the cerebral circulation, experimental models of cerebral ischemia were used to measure abrupt changes in the cortical cerebral blood flow (CBF) at the 'penumbra' (the boundary region between the anterior cerebral artery (ACA) and the middle cerebral artery (MCA))." | 3.69 | Effects of nilvadipine (a dihydropyridine-type calcium entry blocker) on cerebral blood flow in acute experimental brain ischemia in rats. ( Fujii, K; Maruyama, S; Miyasaka, Y; Nagai, S; Tanaka, R, 1996) |
| "The protective effect of nilvadipine, a Ca2+ antagonist, on cerebral ischemia was investigated in spontaneously hypertensive rats." | 3.69 | Protective effect of nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats. ( Fukasawa, H; Kawamura, S; Li, Y; Shirasawa, M; Yasui, N, 1996) |
| "The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries." | 3.68 | Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats. ( Karasawa, A; Kubo, K; Shirakura, S, 1993) |
| "The effects of two dihydropyridine type calcium entry blockers, nilvadipine and nicardipine hydrochloride (nicardipine), on the liberation of free fatty acids (FFAs) were investigated using an experimental model of global cerebral ischemia in rats, and were compared with their pharmacokinetic properties." | 3.68 | Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride. ( Fujiwara, T; Kohsaka, M; Mori, J; Satoh, H; Sogabe, K; Takakura, S; Tokuma, Y; Totsuka, Z, 1992) |
| "The effect of nilvadipine, a dihydropyridine-type calcium entry blocker, on neuronal function during and following ischemia was investigated with a model of focal cerebral ischemia in cats and was compared with that of nicardipine." | 3.68 | Effects of nilvadipine on neuronal function in the ischemic cat brain. ( Furuichi, Y; Kohsaka, M; Mori, J; Satoh, H; Takakura, S, 1992) |
| "The effects of nilvadipine, a dihydropyridine type calcium channel blocker, on cerebral infarction induced by focal brain ischemia was studied in rats." | 3.68 | Nilvadipine, a new calcium channel blocker, reduces ischemic brain injury in rats. ( Handa, J; Mori, J; Satoh, H; Shiino, A; Susumu, T; Takakura, S, 1991) |
| "A model of incomplete cerebral ischemia involving bilateral ligation of the common carotid arteries in rats, was used to examine the potential of a Chinese herbal preparation and of nifedipine to reduce cell damage following cerebral ischemia." | 3.68 | Reduction of cellular damage induced by cerebral ischemia in rats. ( Leung, AW; Mo, ZX; Zheng, YS, 1991) |
| "We investigated the effects of nilvadipine, a calcium antagonist, on cerebral ischemia in rats." | 3.68 | Attenuated neuropathology by nilvadipine after middle cerebral artery occlusion in rats. ( Fukasawa, H; Kawamura, S; Shirasawa, M; Yasui, N, 1991) |
| "We studied the efficacy of preischemic and postischemic systemic treatment with a new calcium antagonist nilvadipine in a permanent focal cerebral ischemia model of spontaneously hypertensive rats." | 3.68 | Effects of the calcium antagonist nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats. ( Handa, J; Matsuda, M; Shiino, A; Susumu, T, 1991) |
| "The effects of nilvadipine, a Ca2+ entry blocker, on focal cerebral ischemia were investigated in rats having unilateral middle cerebral artery occlusion." | 3.68 | Effects of a Ca2+ entry blocker (nilvadipine) on acute focal cerebral ischemia in rats. ( Fukasawa, H; Kawamura, S; Shirasawa, M; Yasui, N, 1991) |
| "In the therapy of acute cerebral ischemia the therapeutic efficacy of nimodipine administered orally is not therapeutically proved until now; the intravenous administration of nimodipine offers the risk of acute hypotensive reactions." | 2.38 | [Calcium channel blockers in therapy of neurologic diseases]. ( Wessely, P; Wöber-Bingöl, C, 1993) |
| "Acidosis accompanying cerebral ischemia activates acid-sensing ion channels (ASIC) causing increases in intracellular calcium concentration ([Ca(2+)]i) and enhanced neuronal death." | 1.36 | ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis. ( Cuevas, J; Katnik, C; Mari, Y, 2010) |
| " We report two cases that developed cerebrovascular and cardiovascular adverse events associated with aggressive treatment of increased blood pressure by the use of sublingual nifedipine capsule." | 1.32 | Adverse events associated with aggressive treatment of increased blood pressure. ( Akay, S; Ayrik, C; Cevik, AA; Yanturali, S, 2004) |
| "Nifedipine pretreatment had no influence on oxygen delivery in placenta and fetal cerebrum during and after ischemia." | 1.31 | Short therapeutic window for nifedipine in transient intrauterine ischemia in fetal rat brain. ( Araki, T; Koshino, T; Nagano, R; Nakai, A; Oya, A; Shibazaki, Y; Taniuchi, Y, 2002) |
| "Induction of chemical anoxia, using sodium azide in cerebellar granule cells maintained in primary culture, was evaluated as an in vitro assay for screening of potential neuroprotective compounds." | 1.29 | Characterization of a chemical anoxia model in cerebellar granule neurons using sodium azide: protection by nifedipine and MK-801. ( Drejer, J; Frandsen, A; Schousboe, A; Varming, T, 1996) |
| " The dosage was 1." | 1.28 | CBF decreases after calcium antagonist treatment in acute ischemic stroke. ( Andersen, A; Paulson, OB; Vorstrup, S, 1989) |
| "Verapamil was most active as a vasodilator in muscular microvasculature." | 1.27 | Pharmacologic inhibition of cerebral vasospasm in ischemia, hallucinogen ingestion, and hypomagnesemia: barbiturates, calcium antagonists, and magnesium. ( Altura, BM; Altura, BT, 1983) |
| "Thus, the cerebral ischemia, produced by unilateral common carotid artery (CCA) occlusion, was studied." | 1.27 | Effect of the calcium entry blocker NB-818 on cerebral blood flow after unilateral carotid occlusion in the Mongolian gerbil. ( Nishikibe, M, 1988) |
| " The dosage was 1." | 1.27 | Calcium antagonist (PY 108-068) treatment may further decrease flow in ischemic areas in acute stroke. ( Andersen, A; Blegvad, N; Paulson, OB; Vorstrup, S, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (19.64) | 18.7374 |
| 1990's | 22 (39.29) | 18.2507 |
| 2000's | 17 (30.36) | 29.6817 |
| 2010's | 4 (7.14) | 24.3611 |
| 2020's | 2 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Tenti, G | 1 |
| Parada, E | 1 |
| León, R | 1 |
| Egea, J | 1 |
| Martínez-Revelles, S | 1 |
| Briones, AM | 1 |
| Sridharan, V | 1 |
| López, MG | 1 |
| Ramos, MT | 1 |
| Menéndez, JC | 1 |
| Cakir, T | 1 |
| Yucetas, SC | 1 |
| Yazici, GN | 1 |
| Sunar, M | 1 |
| Arslan, YK | 1 |
| Suleyman, H | 1 |
| Kalar, I | 1 |
| Xu, H | 1 |
| Secnik, J | 1 |
| Schwertner, E | 1 |
| Kramberger, MG | 1 |
| Winblad, B | 1 |
| von Euler, M | 1 |
| Eriksdotter, M | 1 |
| Garcia-Ptacek, S | 1 |
| Watson, K | 1 |
| Broscious, R | 1 |
| Devabhakthuni, S | 1 |
| Noel, ZR | 1 |
| Cipolla, MJ | 1 |
| Bullinger, LV | 1 |
| Mari, Y | 1 |
| Katnik, C | 1 |
| Cuevas, J | 1 |
| Pei, L | 2 |
| Li, Y | 3 |
| Zhang, GY | 5 |
| Gui, ZH | 1 |
| Zhu, ZM | 1 |
| Yamato, M | 1 |
| Shiba, T | 1 |
| Ide, T | 1 |
| Honda, Y | 1 |
| Yamada, K | 1 |
| Tsutsui, H | 1 |
| Zhang, C | 2 |
| Shen, W | 2 |
| Zhang, G | 5 |
| Zhang, Q | 3 |
| Meng, F | 1 |
| Tian, H | 2 |
| Liu, Y | 1 |
| Hou, XY | 1 |
| Xu, TL | 1 |
| Li, H | 2 |
| Iwasaki, K | 2 |
| Mishima, K | 2 |
| Egashira, N | 2 |
| Al-Khatib, IH | 1 |
| Ishibashi, D | 1 |
| Irie, K | 1 |
| Kobayashi, H | 1 |
| Egawa, T | 1 |
| Fujiwara, M | 2 |
| Zhang, CY | 1 |
| Shen, WH | 1 |
| Yanturali, S | 1 |
| Akay, S | 1 |
| Ayrik, C | 1 |
| Cevik, AA | 1 |
| Takahara, A | 1 |
| Konda, T | 1 |
| Enomoto, A | 1 |
| Kondo, N | 1 |
| Hao, ZB | 1 |
| Pei, DS | 1 |
| Guan, QH | 1 |
| Prior, M | 1 |
| Thatcher, N | 1 |
| Morris, P | 1 |
| Reese, T | 1 |
| Bachelard, H | 1 |
| Takagaki, Y | 1 |
| Yoshimitsu, Y | 1 |
| Hatip-Al-Khatib, I | 1 |
| Weir, B | 1 |
| Gygax, P | 1 |
| Wiernsperger, N | 1 |
| Altura, BM | 1 |
| Altura, BT | 1 |
| Brandt, L | 1 |
| Ljunggren, B | 1 |
| Andersson, KE | 1 |
| Edvinsson, L | 1 |
| MacKenzie, E | 1 |
| Tamura, A | 1 |
| Teasdale, G | 1 |
| Wessely, P | 1 |
| Wöber-Bingöl, C | 1 |
| Shirakura, S | 1 |
| Karasawa, A | 1 |
| Kubo, K | 1 |
| Kawamura, S | 3 |
| Shirasawa, M | 3 |
| Yasui, N | 3 |
| Fukasawa, H | 3 |
| Tanaka, R | 1 |
| Miyasaka, Y | 1 |
| Maruyama, S | 1 |
| Nagai, S | 1 |
| Fujii, K | 1 |
| Varming, T | 1 |
| Drejer, J | 1 |
| Frandsen, A | 1 |
| Schousboe, A | 1 |
| Hayashi, H | 1 |
| Takagi, N | 1 |
| Kamimoto, N | 1 |
| Takeo, S | 1 |
| Tsubokawa, H | 1 |
| Oguro, K | 1 |
| Robinson, HP | 1 |
| Masuzawa, T | 1 |
| Kawai, N | 1 |
| Akopov, SE | 2 |
| Simonian, NA | 1 |
| Kazarian, AV | 1 |
| Pisani, A | 1 |
| Calabresi, P | 1 |
| Tozzi, A | 1 |
| D'Angelo, V | 1 |
| Bernardi, G | 1 |
| Sasaki, R | 1 |
| Hirota, K | 1 |
| Masuda, A | 1 |
| Nakai, A | 1 |
| Shibazaki, Y | 1 |
| Taniuchi, Y | 1 |
| Nagano, R | 1 |
| Oya, A | 1 |
| Koshino, T | 1 |
| Araki, T | 1 |
| Takakura, S | 3 |
| Sogabe, K | 1 |
| Satoh, H | 4 |
| Mori, J | 3 |
| Fujiwara, T | 1 |
| Totsuka, Z | 1 |
| Tokuma, Y | 1 |
| Kohsaka, M | 2 |
| Vesel'skiĭ, ISh | 1 |
| Sanik, AV | 1 |
| Udotova, SA | 1 |
| Proskurin, VV | 1 |
| Martynov, IuS | 1 |
| Ivleva, AIa | 1 |
| Lepakhin, VK | 1 |
| Furuichi, Y | 1 |
| Gabrielian, ES | 1 |
| Grigorian, GS | 1 |
| Tunian, IuS | 1 |
| Susumu, T | 2 |
| Shiino, A | 2 |
| Handa, J | 3 |
| Leung, AW | 1 |
| Mo, ZX | 1 |
| Zheng, YS | 1 |
| Matsuda, M | 2 |
| Silver, IA | 1 |
| Erecińska, M | 1 |
| Tanaka, S | 1 |
| Ashida, S | 1 |
| Akashi, A | 1 |
| Kidooka, M | 1 |
| Oczkowski, WJ | 1 |
| Hachinski, VC | 1 |
| Bogousslavsky, J | 1 |
| Barnett, HJ | 1 |
| Carruthers, SG | 1 |
| Ishchenko, MM | 1 |
| Lobas, VA | 1 |
| Vorstrup, S | 2 |
| Paulson, OB | 2 |
| Andersen, A | 2 |
| Kuwaki, T | 1 |
| Ono, T | 1 |
| Shibayama, F | 1 |
| Yamashita, T | 1 |
| Nishimura, T | 1 |
| Nishikibe, M | 1 |
| Blegvad, N | 1 |
3 reviews available for nifedipine and Cerebral Ischemia
| Article | Year |
|---|---|
Focused Update on Pharmacologic Management of Hypertensive Emergencies.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Emergencies; Enalapri | 2018 |
Calcium antagonists, cerebral ischemia and vasospasm.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebral Arteries; Cerebrovascular Circulat | 1984 |
[Calcium channel blockers in therapy of neurologic diseases].
Topics: Brain Ischemia; Calcium Channel Blockers; Cluster Headache; Flunarizine; Humans; Migraine Disorders; | 1993 |
5 trials available for nifedipine and Cerebral Ischemia
| Article | Year |
|---|---|
Calcium antagonists, cerebral ischemia and vasospasm.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebral Arteries; Cerebrovascular Circulat | 1984 |
Effects of nifedipine and nicardipine on regional cerebral blood flow distribution in patients with arterial hypertension.
Topics: Adult; Aged; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; | 1996 |
[Calcium antagonists in the treatment of cerebrovascular diseases].
Topics: Adult; Aged; Brain Ischemia; Carotid Artery, Internal; Carotid Stenosis; Cerebrovascular Circulation | 1992 |
A double-blind, randomized trial of PY108-068 in acute ischemic cerebral infarction.
Topics: Acute Disease; Aged; Aged, 80 and over; Brain Ischemia; Clinical Trials as Topic; Double-Blind Metho | 1989 |
[Effect of calcium antagonists on cerebral and systemic hemodynamics in patients with ischemic disorders of cerebrovascular circulation].
Topics: Adult; Aged; Brain Ischemia; Carotid Artery Diseases; Carotid Artery, Internal; Cerebrovascular Circ | 1989 |
49 other studies available for nifedipine and Cerebral Ischemia
| Article | Year |
|---|---|
New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channels, L-Type; Calcium Signaling; Cell Line, Tumor; Dih | 2014 |
Effects of Benidipine Hydrochloride on Ischemia Reperfusion Injury of Rat Brain.
Topics: Animals; Brain; Brain Ischemia; Male; Neuroprotective Agents; Nifedipine; Random Allocation; Rats; R | 2021 |
Calcium channel blockers, survival and ischaemic stroke in patients with dementia: a Swedish registry study.
Topics: Alzheimer Disease; Amlodipine; Brain Ischemia; Calcium Channel Blockers; Humans; Hypertension; Ische | 2021 |
Reactivity of brain parenchymal arterioles after ischemia and reperfusion.
Topics: Animals; Arterioles; Brain; Brain Ischemia; Cerebrovascular Circulation; Enzyme Inhibitors; Male; Mi | 2008 |
ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis.
Topics: 2-Amino-5-phosphonovalerate; Acid Sensing Ion Channels; Acidosis; Animals; Brain Ischemia; Calcium; | 2010 |
[Effects of ischemia/reperfusion on the phosphotyrosine proteins contents in hippocampus].
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Excitatory Amino Acid Antagonis | 2001 |
Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Male; Mitochondria; Nifedipine; Oxidative Stress; Rats | 2011 |
N-methyl-D-aspartate receptor and L-type voltage-gated Ca(2+) channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Caspase 3; Caspase Inhi | 2002 |
Biphasic activation of apoptosis signal-regulating kinase 1-stress-activated protein kinase 1-c-Jun N-terminal protein kinase pathway is selectively mediated by Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involving oxidat
Topics: Acetylcysteine; Animals; Antioxidants; Brain Ischemia; Calcium; Calcium Channel Blockers; Calcium Ch | 2003 |
L-type voltage-gated calcium channel attends regulation of tyrosine phosphorylation of NMDA receptor subunit 2A induced by transient brain ischemia.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relations | 2003 |
Antioxidant NAC and AMPA/KA receptor antagonist DNQX inhibited JNK3 activation following global ischemia in rat hippocampus.
Topics: Acetylcysteine; Animals; Brain Ischemia; Calcium Channel Blockers; Excitatory Amino Acid Antagonists | 2003 |
Signal transducer and activator of transcription-3 activation is mediated by N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel during cerebral ischemia in rat hippocampus.
Topics: Active Transport, Cell Nucleus; Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, | 2003 |
Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats.
Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channel Blockers; Calibration; Genes, bcl-2; Glyceraldeh | 2003 |
Ischemia-induced release of cytochrome c from mitochondria and up-regulation of Bcl-2 expression in rat hippocampus.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Cytochromes c; Cytosol; | 2004 |
Adverse events associated with aggressive treatment of increased blood pressure.
Topics: Administration, Oral; Aged; Aged, 80 and over; Brain Ischemia; Capsules; Chronic Disease; Female; He | 2004 |
Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Typ | 2004 |
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Brain Ischemia; Calciu | 2005 |
The phenomenon of "pre-ischaemic conditioning" in the brain only partly involves the NMDA receptor: a magnetic resonance study.
Topics: Animals; Brain; Brain Ischemia; Calcium; Calcium Channel Blockers; Dizocilpine Maleate; Egtazic Acid | 2005 |
Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Brain Ischemia; Calcium Channel Blockers; Male; Maze Lear | 2007 |
Hypotension induced changes in cerebral microflow and EEG and their pharmacological alterations.
Topics: Animals; Blood Pressure; Brain Ischemia; Cats; Cerebrovascular Circulation; Electroencephalography; | 1983 |
Pharmacologic inhibition of cerebral vasospasm in ischemia, hallucinogen ingestion, and hypomagnesemia: barbiturates, calcium antagonists, and magnesium.
Topics: Animals; Barbiturates; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Magnesium; Metab | 1983 |
Effects of topical application of a calcium antagonist (nifedipine) on feline cortical pial microvasculature under normal conditions and in focal ischemia.
Topics: Animals; Arterioles; Brain Ischemia; Cats; Female; Male; Microcirculation; Nifedipine; Pia Mater; Py | 1983 |
Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Ischemia; Calcium C | 1993 |
Protective effect of nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Dose-Response Relationship, | 1996 |
Effects of nilvadipine (a dihydropyridine-type calcium entry blocker) on cerebral blood flow in acute experimental brain ischemia in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebrov | 1996 |
Characterization of a chemical anoxia model in cerebellar granule neurons using sodium azide: protection by nifedipine and MK-801.
Topics: Animals; Azides; Brain Ischemia; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Dose-Response Rel | 1996 |
Microsphere embolism-induced changes in presynaptic function of the cerebral cortex in rats.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Dilti | 1996 |
Intracellular inositol 1,3,4,5-tetrakisphosphate enhances the calcium current in hippocampal CA1 neurones of the gerbil after ischaemia.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Electro | 1996 |
L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cytopho | 1998 |
Nifedipine-induced transient cerebral ischemia in a child with Cockayne syndrome.
Topics: Arteriosclerosis; Brain Ischemia; Calcium Channel Blockers; Child; Cockayne Syndrome; Female; Humans | 1997 |
Nuclear factor kappaB activation is mediated by NMDA and non-NMDA receptor and L-type voltage-gated Ca(2+) channel following severe global ischemia in rat hippocampus.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Cytoplasm; Excitatory A | 2002 |
[Effect of ischemia/reperfusion on the phosphorylation of synaptosomal tyrosine of hippocampus of Mongolian gerbils].
Topics: Animals; Brain Ischemia; Calcium Channels, L-Type; Gerbillinae; Hippocampus; Ketamine; Nifedipine; P | 2000 |
Short therapeutic window for nifedipine in transient intrauterine ischemia in fetal rat brain.
Topics: Animals; Brain; Brain Ischemia; Female; Fetus; Mitochondria; Nifedipine; Oxygen Consumption; Pregnan | 2002 |
Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Decerebrate State; Fatty Acids, Nonesterif | 1992 |
[The korinfar and actovegin treatment of patients with a chronic ischemic disorder of the cerebral circulation].
Topics: Adult; Aged; Brain Ischemia; Cerebrovascular Circulation; Chronic Disease; Drug Evaluation; Female; | 1992 |
Effects of nilvadipine on neuronal function in the ischemic cat brain.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebrovascular Circulation; Evoked | 1992 |
["Dynamic" component of carotid artery stenosis in patients with cerebrovascular disorders].
Topics: Adult; Aged; Brain; Brain Ischemia; Carotid Artery Diseases; Carotid Artery, Internal; Humans; Middl | 1991 |
Nilvadipine, a new calcium channel blocker, reduces ischemic brain injury in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Nicardipine; Nifedipine; Rat | 1991 |
Reduction of cellular damage induced by cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Cell Survival; Drugs, Chinese Herbal; Female; Male; Neurons; Nifedipine; Ra | 1991 |
Attenuated neuropathology by nilvadipine after middle cerebral artery occlusion in rats.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebral Arte | 1991 |
Effects of the calcium antagonist nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Cerebral Infar | 1991 |
Effects of a Ca2+ entry blocker (nilvadipine) on acute focal cerebral ischemia in rats.
Topics: Acute Disease; Animals; Brain; Brain Edema; Brain Ischemia; Calcium Channel Blockers; Cerebral Infar | 1991 |
Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channels; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpi | 1990 |
Effects of antihypertensive drugs on experimental cerebral ischemia in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Brain Chemistry; Brain Ischemia; Carotid A | 1990 |
Effect of calcium antagonist and agonist on free fatty acid liberation in the ischemic brain of rats.
Topics: Animals; Arachidonic Acids; Brain; Brain Ischemia; Disease Models, Animal; Fatty Acids, Nonesterifie | 1987 |
CBF decreases after calcium antagonist treatment in acute ischemic stroke.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Calcium Channel Blockers; Cerebrovasc | 1989 |
Nilvadipine attenuates ischemic degradation of gerbil brain cytoskeletal proteins.
Topics: Animals; Brain; Brain Ischemia; Calmodulin-Binding Proteins; Clathrin; Cytoskeletal Proteins; Dose-R | 1989 |
Effect of the calcium entry blocker NB-818 on cerebral blood flow after unilateral carotid occlusion in the Mongolian gerbil.
Topics: Animals; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Dihy | 1988 |
Calcium antagonist (PY 108-068) treatment may further decrease flow in ischemic areas in acute stroke.
Topics: Acute Disease; Adult; Aged; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circula | 1986 |