nifedipine has been researched along with Cerebral Infarction in 25 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined the effect of a Ca antagonist (nilvadipine) on the occurrence or recurrence of symptomatic stroke in hypertensive patients with MRI-defined asymptomatic cerebral infarction (ACI), periventricular hyperintensity (PVH), and deep and subcortical white matter hyperintensity (DSWMH), with or without a history of stroke, and evaluated the effect of long-term treatment on the lesions." | 9.12 | Effect of the Ca antagonist nilvadipine on stroke occurrence or recurrence and extension of asymptomatic cerebral infarction in hypertensive patients with or without history of stroke (PICA Study). 1. Design and results at enrollment. ( Fukuuchi, Y; Hirai, S; Okudera, T; Shinohara, Y; Terashi, A; Tohgi, H; Yamaguchi, T, 2007) |
| "The protective effect of nilvadipine, a Ca2+ antagonist, on cerebral ischemia was investigated in spontaneously hypertensive rats." | 7.69 | Protective effect of nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats. ( Fukasawa, H; Kawamura, S; Li, Y; Shirasawa, M; Yasui, N, 1996) |
| "Extracellular Ca2+ (Ca2+ e) changes in the cerebral infarction areas of the rats with the double-tubulus calcium ion-selective microelectrodes made of calcium active material, di-2-isooctylphenyl calcium phosphate to observe the effects of two concentrations of nifedipine given before the middle cerebral artery (MCA) occlusion." | 7.68 | [Extracellular calcium in the rat brains and the effects of nifedipine in experimental cerebral infarction using calcium ion selective microelectrodes in vivo]. ( Niu, G, 1992) |
| "The effect of nilvadipine, a newly developed calcium antagonist, on regional cerebral blood flow (rCBF) was investigated in 7 patients with chronic cerebral infarction." | 7.68 | Effect of single oral administration of nilvadipine on cerebral blood flow in chronic cerebral infarction. ( Bokura, K; Kobayashi, S; Murao, M; Okada, K; Suyama, N; Tsunematsu, T; Yamaguchi, S, 1992) |
| "We studied the efficacy of preischemic and postischemic systemic treatment with a new calcium antagonist nilvadipine in a permanent focal cerebral ischemia model of spontaneously hypertensive rats." | 7.68 | Effects of the calcium antagonist nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats. ( Handa, J; Matsuda, M; Shiino, A; Susumu, T, 1991) |
| "The effects of nilvadipine, a Ca2+ entry blocker, on focal cerebral ischemia were investigated in rats having unilateral middle cerebral artery occlusion." | 7.68 | Effects of a Ca2+ entry blocker (nilvadipine) on acute focal cerebral ischemia in rats. ( Fukasawa, H; Kawamura, S; Shirasawa, M; Yasui, N, 1991) |
| "Nifedipine was administered intracerebroventricularly (5 microL) or intrathecally (20 microL) at graded doses (0." | 5.30 | Effects of nifedipine on bladder overactivity in rats with cerebral infarction. ( Komatsu, K; Kontani, H; Mita, E; Nakamura, Y; Namiki, M; Yokoyama, O, 1999) |
| "We examined the effect of a Ca antagonist (nilvadipine) on the occurrence or recurrence of symptomatic stroke in hypertensive patients with MRI-defined asymptomatic cerebral infarction (ACI), periventricular hyperintensity (PVH), and deep and subcortical white matter hyperintensity (DSWMH), with or without a history of stroke, and evaluated the effect of long-term treatment on the lesions." | 5.12 | Effect of the Ca antagonist nilvadipine on stroke occurrence or recurrence and extension of asymptomatic cerebral infarction in hypertensive patients with or without history of stroke (PICA Study). 1. Design and results at enrollment. ( Fukuuchi, Y; Hirai, S; Okudera, T; Shinohara, Y; Terashi, A; Tohgi, H; Yamaguchi, T, 2007) |
| "The protective effect of nilvadipine, a Ca2+ antagonist, on cerebral ischemia was investigated in spontaneously hypertensive rats." | 3.69 | Protective effect of nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats. ( Fukasawa, H; Kawamura, S; Li, Y; Shirasawa, M; Yasui, N, 1996) |
| " DESIGN OF STUDIES: Mean cerebral circulation parameters were studied in chronic stroke patients with hypertension and treated acutely or chronically (2 weeks) with nicardipine or nifedipine retard." | 3.68 | Effects of dihydropyridines on cerebral blood vessels. ( Hashimoto, H; Kuriyama, Y; Nagatsuka, K; Omae, T; Sawada, T, 1993) |
| "Extracellular Ca2+ (Ca2+ e) changes in the cerebral infarction areas of the rats with the double-tubulus calcium ion-selective microelectrodes made of calcium active material, di-2-isooctylphenyl calcium phosphate to observe the effects of two concentrations of nifedipine given before the middle cerebral artery (MCA) occlusion." | 3.68 | [Extracellular calcium in the rat brains and the effects of nifedipine in experimental cerebral infarction using calcium ion selective microelectrodes in vivo]. ( Niu, G, 1992) |
| "The effect of nilvadipine, a newly developed calcium antagonist, on regional cerebral blood flow (rCBF) was investigated in 7 patients with chronic cerebral infarction." | 3.68 | Effect of single oral administration of nilvadipine on cerebral blood flow in chronic cerebral infarction. ( Bokura, K; Kobayashi, S; Murao, M; Okada, K; Suyama, N; Tsunematsu, T; Yamaguchi, S, 1992) |
| "The effects of nilvadipine, a dihydropyridine type calcium channel blocker, on cerebral infarction induced by focal brain ischemia was studied in rats." | 3.68 | Nilvadipine, a new calcium channel blocker, reduces ischemic brain injury in rats. ( Handa, J; Mori, J; Satoh, H; Shiino, A; Susumu, T; Takakura, S, 1991) |
| "We investigated the effects of nilvadipine, a calcium antagonist, on cerebral ischemia in rats." | 3.68 | Attenuated neuropathology by nilvadipine after middle cerebral artery occlusion in rats. ( Fukasawa, H; Kawamura, S; Shirasawa, M; Yasui, N, 1991) |
| "We studied the efficacy of preischemic and postischemic systemic treatment with a new calcium antagonist nilvadipine in a permanent focal cerebral ischemia model of spontaneously hypertensive rats." | 3.68 | Effects of the calcium antagonist nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats. ( Handa, J; Matsuda, M; Shiino, A; Susumu, T, 1991) |
| "The effects of nilvadipine, a Ca2+ entry blocker, on focal cerebral ischemia were investigated in rats having unilateral middle cerebral artery occlusion." | 3.68 | Effects of a Ca2+ entry blocker (nilvadipine) on acute focal cerebral ischemia in rats. ( Fukasawa, H; Kawamura, S; Shirasawa, M; Yasui, N, 1991) |
| "Nifedipine (Adalat) was used in managing acute hypertension in 20 patients with coronary heart disease during endarterectomy for carotid stenosis." | 3.67 | [Treatment of hypertensive crises with nifedipine (Adalat) in patients at risk of infarct during interventions on the extracranial cerebral vessels]. ( Balzer, K; Fanoulas, G; Fidorra, K; Gresser, S; Müller, C, 1987) |
| "A 31-year-old woman developed bilateral posterior ischemic optic neuropathy and infarctions of the cerebral arterial border zones and spinal cord after correction of malignant hypertension." | 1.35 | Simultaneous posterior ischemic optic neuropathy, cerebral border zone infarction, and spinal cord infarction after correction of malignant hypertension. ( An, SJ; Choi, JH; Choi, KD; Kim, HJ; Kim, JS; Lee, JE, 2008) |
| "Nifedipine was administered intracerebroventricularly (5 microL) or intrathecally (20 microL) at graded doses (0." | 1.30 | Effects of nifedipine on bladder overactivity in rats with cerebral infarction. ( Komatsu, K; Kontani, H; Mita, E; Nakamura, Y; Namiki, M; Yokoyama, O, 1999) |
| "In addition, evolution of cerebral infarction was studied at 6 hours and 12 hours post-occlusion by magnetic resonance imaging (MRI)." | 1.28 | [Ca++ antagonist and acute brain ischemia: effects of nilvadipine and nicardipine on middle cerebral artery occlusion in rats]. ( Handa, J; Inubushi, T; Kido, C; Matsuda, M; Morikawa, S; Shiino, A; Susumu, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 19 (76.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, JH | 1 |
| Choi, KD | 1 |
| Kim, JS | 1 |
| Kim, HJ | 1 |
| Lee, JE | 1 |
| An, SJ | 1 |
| Wu, CS | 1 |
| Sung, SF | 1 |
| Tong, SH | 1 |
| Ong, CT | 1 |
| Takahara, A | 1 |
| Konda, T | 1 |
| Enomoto, A | 1 |
| Kondo, N | 1 |
| Shinohara, Y | 2 |
| Tohgi, H | 1 |
| Hirai, S | 1 |
| Terashi, A | 1 |
| Fukuuchi, Y | 1 |
| Yamaguchi, T | 1 |
| Okudera, T | 1 |
| Li, Y | 3 |
| Kawamura, S | 5 |
| Yasui, N | 5 |
| Shirasawa, M | 5 |
| Fukasawa, H | 5 |
| Kuriyama, Y | 1 |
| Hashimoto, H | 1 |
| Nagatsuka, K | 1 |
| Sawada, T | 1 |
| Omae, T | 1 |
| Lee, YJ | 1 |
| Jy, W | 1 |
| Horstman, LL | 1 |
| Janania, J | 1 |
| Reyes, Y | 1 |
| Kelley, RE | 1 |
| Ahn, YS | 1 |
| Takagi, Y | 1 |
| Hashimoto, N | 1 |
| Goto, Y | 1 |
| Azuma, T | 1 |
| Matsubara, T | 1 |
| Nagai, Y | 1 |
| Funauchi, M | 1 |
| Fujimoto, T | 1 |
| Saito, T | 1 |
| Tone, K | 1 |
| Sakoda, S | 1 |
| Miyazaki, H | 1 |
| Tanaka, S | 1 |
| Fujii, Y | 1 |
| Shimizu, K | 1 |
| Nagashima, K | 1 |
| Kamibayashi, M | 1 |
| Uehara, T | 1 |
| Okuma, Y | 1 |
| Nomura, Y | 1 |
| Nakamura, Y | 1 |
| Yokoyama, O | 1 |
| Komatsu, K | 1 |
| Mita, E | 1 |
| Namiki, M | 1 |
| Kontani, H | 1 |
| Niu, G | 1 |
| Morton, C | 1 |
| Hickey-Dwyer, M | 1 |
| Kobayashi, S | 1 |
| Yamaguchi, S | 1 |
| Okada, K | 1 |
| Suyama, N | 1 |
| Bokura, K | 1 |
| Murao, M | 1 |
| Tsunematsu, T | 1 |
| Hayashi, T | 1 |
| Goto, T | 1 |
| Tateishi, T | 1 |
| Yoshimine, N | 1 |
| Kuzuya, F | 1 |
| Akopov, SE | 1 |
| Grigorian, GS | 1 |
| Kazarian, AV | 1 |
| Mkhitarian, GS | 1 |
| Tunian, IuS | 1 |
| Gabrielian, ES | 1 |
| Takakura, S | 1 |
| Susumu, T | 3 |
| Satoh, H | 1 |
| Mori, J | 1 |
| Shiino, A | 3 |
| Handa, J | 3 |
| Matsuda, M | 2 |
| Morikawa, S | 1 |
| Kido, C | 1 |
| Inubushi, T | 1 |
| Müller, C | 1 |
| Gresser, S | 1 |
| Fanoulas, G | 1 |
| Fidorra, K | 1 |
| Balzer, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Phase III-b, Multi-centre, Open-label, Parallel Study of Enoxaparin (Low Molecular Weight Heparin) Given Concomitantly With Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Gastric and Gastro-oesophageal Cancer[NCT00718354] | Phase 3 | 740 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nifedipine and Cerebral Infarction
| Article | Year |
|---|---|
[PICA study--hypertension and asymptomatic cerebral infarction].
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Cerebral Infarcti | 2006 |
2 trials available for nifedipine and Cerebral Infarction
| Article | Year |
|---|---|
Effect of the Ca antagonist nilvadipine on stroke occurrence or recurrence and extension of asymptomatic cerebral infarction in hypertensive patients with or without history of stroke (PICA Study). 1. Design and results at enrollment.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Cerebral Infarcti | 2007 |
Effects of antihypertensive agents on circadian blood pressure in hypertensive patients with previous brain infarction.
Topics: Acebutolol; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Ca | 1997 |
22 other studies available for nifedipine and Cerebral Infarction
| Article | Year |
|---|---|
Simultaneous posterior ischemic optic neuropathy, cerebral border zone infarction, and spinal cord infarction after correction of malignant hypertension.
Topics: Adult; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Brain; Brain Stem Infarctions; C | 2008 |
Multiple cerebral infarctions related to famotidine-induced eosinophilia.
Topics: Acarbose; Adrenergic alpha-1 Receptor Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulc | 2012 |
Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Typ | 2004 |
Therapeutic effects of nilvadipine on rat focal cerebral ischemia.
Topics: Animals; Blood Pressure; Brain; Calcium Channel Blockers; Cerebral Arteries; Cerebral Infarction; Is | 1994 |
Effects of dihydropyridines on cerebral blood vessels.
Topics: Administration, Oral; Blood Pressure; Cerebral Infarction; Cerebrovascular Circulation; Cerebrovascu | 1993 |
Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias.
Topics: Adult; Aged; Alzheimer Disease; Blood Platelets; Cerebral Infarction; Dementia, Multi-Infarct; Femal | 1993 |
Protective effect of nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Dose-Response Relationship, | 1996 |
Haemodynamic ischaemia in paediatric moyamoya disease associated with renovascular hypertension.
Topics: Antihypertensive Agents; Brain; Cerebral Angiography; Cerebral Cortex; Cerebral Infarction; Cerebral | 1997 |
Effects of treatment with nilvadipine on cerebral ischemia in rats.
Topics: Animals; Antihypertensive Agents; Brain; Calcium Channel Blockers; Cerebral Infarction; Hypertension | 1998 |
Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury.
Topics: Animals; Body Temperature; Brain Edema; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Prote | 1999 |
Effects of nifedipine on bladder overactivity in rats with cerebral infarction.
Topics: Animals; Calcium Channel Blockers; Cerebral Infarction; Male; Nifedipine; Rats; Rats, Sprague-Dawley | 1999 |
[Extracellular calcium in the rat brains and the effects of nifedipine in experimental cerebral infarction using calcium ion selective microelectrodes in vivo].
Topics: Animals; Brain; Calcium; Calcium Channels; Cerebral Infarction; Extracellular Space; Male; Microelec | 1992 |
Cortical blindness after nifedipine treatment.
Topics: Blindness; Cerebral Infarction; Humans; Male; Middle Aged; Nifedipine; Occipital Lobe | 1992 |
Effect of single oral administration of nilvadipine on cerebral blood flow in chronic cerebral infarction.
Topics: Administration, Oral; Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Cerebral In | 1992 |
Nocturnal blood pressure monitored by ambulatory blood pressure measurement in elderly hypertensive patients.
Topics: Aged; Blood Pressure; Blood Pressure Determination; Cerebral Infarction; Circadian Rhythm; Diabetes | 1992 |
[Status of the prostacyclin-thromboxane balance in patients with cerebrovascular disorders and the effect of the treatment with nifedipine].
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Aged; Cerebral Infarction; Cerebrovascular Circulation; | 1991 |
Nilvadipine, a new calcium channel blocker, reduces ischemic brain injury in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Nicardipine; Nifedipine; Rat | 1991 |
[Ca++ antagonist and acute brain ischemia: effects of nilvadipine and nicardipine on middle cerebral artery occlusion in rats].
Topics: Acute Disease; Animals; Calcium Channel Blockers; Cerebral Infarction; Constriction; Ischemic Attack | 1991 |
Attenuated neuropathology by nilvadipine after middle cerebral artery occlusion in rats.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebral Arte | 1991 |
Effects of the calcium antagonist nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Cerebral Infar | 1991 |
Effects of a Ca2+ entry blocker (nilvadipine) on acute focal cerebral ischemia in rats.
Topics: Acute Disease; Animals; Brain; Brain Edema; Brain Ischemia; Calcium Channel Blockers; Cerebral Infar | 1991 |
[Treatment of hypertensive crises with nifedipine (Adalat) in patients at risk of infarct during interventions on the extracranial cerebral vessels].
Topics: Adult; Aged; Aged, 80 and over; Cardiac Output, Low; Carotid Artery Diseases; Carotid Artery, Intern | 1987 |