nifedipine has been researched along with Brain Vascular Disorders in 48 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effect of sublingual nifedipine was evaluated in 39 cases of hypertensive emergencies (diastolic blood pressure greater than or equal to 120 mm Hg with impending organ failure, loss of vital function or death)." | 9.07 | Sublingual nifedipine in hypertensive emergencies with special reference to cerebrovascular accident. ( Gambhir, IS; Gupta, SS; Singh, DS, 1991) |
| " Two cases and a review of the literature relating to treatment of hypertensive emergencies with nifedipine are presented." | 7.67 | Nifedipine in the management of hypertensive emergencies: report of two cases and review of the literature. ( Checcio, LM; Cohan, JA, 1985) |
| "The drug is equally effective in treating hypertension in elderly and younger patients and does not appear to adversely affect glucose or lipid metabolism." | 6.39 | Nilvadipine. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic use in hypertension and potential in cerebrovascular disease and angina. ( Brogden, RN; McTavish, D, 1995) |
| "A single-blind trial was conducted under the direction of the Shanghai Institute of Hypertension in 1632 subjects aged 60-79 years alternatively allocated to either nifedipine or placebo after a 4-week placebo run-in period between 1987 and 1990 with mean follow-up of 30 months." | 5.08 | Shanghai trial of nifedipine in the elderly (STONE). ( Ghadirian, P; Gong, L; Hamet, P; Kong, D; LeLorier, J; Pagé, V; Zhang, W; Zhu, J; Zhu, Y, 1996) |
| " Angiotensin converting enzyme inhibitors (ACE-I) significantly retarded the development of end-stage renal failure compared to antihypertensives other than ACE-I (mostly nifedipine), and the effect was evident particularly in patients with proteinuria below the median (2." | 5.08 | Predictors of the progression of diabetic nephropathy and the beneficial effect of angiotensin-converting enzyme inhibitors in NIDDM patients. ( Babazono, T; Hirayama, M; Ishii, A; Omori, Y; Takahashi, C; Takeda, M; Tomonaga, O; Ujihara, U; Yokoyama, H, 1997) |
| "Effect of sublingual nifedipine was evaluated in 39 cases of hypertensive emergencies (diastolic blood pressure greater than or equal to 120 mm Hg with impending organ failure, loss of vital function or death)." | 5.07 | Sublingual nifedipine in hypertensive emergencies with special reference to cerebrovascular accident. ( Gambhir, IS; Gupta, SS; Singh, DS, 1991) |
| " hypertension clinical trial databases for amlodipine (Norvasc) and nifedipine in the gastrointestinal therapeutic system (GITS) formulation (Procardia XL)." | 4.80 | Safety of long-acting dihydropyridine calcium channel blockers in hypertensive patients. ( Kloner, RA; Levenstein, M; Materson, BJ; Vetrovec, GW, 1998) |
| "MCAs from DSS rats after stroke constricted in response to vasopressin but were unable to constrict in response to pressure or PDB in the presence of nifedipine, whereas those from DSS rats before stroke and from DSR rats constricted in response to all the stimuli." | 3.71 | Cerebrovascular alterations in pressure and protein kinase C-mediated constriction in Dahl salt-sensitive rats. ( Payne, GW; Smeda, JS, 2002) |
| " We have previously described an increased sensitivity to inhibition by nifedipine of noradrenaline-induced contractures of blood vessels in hypertension." | 3.69 | Relationship between nifedipine sensitivity of aortae and blood pressure of stroke-prone spontaneously hypertensive rats. ( Iwanov, V; Jiang, GC; Moulds, RF, 1996) |
| " DESIGN OF STUDIES: Mean cerebral circulation parameters were studied in chronic stroke patients with hypertension and treated acutely or chronically (2 weeks) with nicardipine or nifedipine retard." | 3.68 | Effects of dihydropyridines on cerebral blood vessels. ( Hashimoto, H; Kuriyama, Y; Nagatsuka, K; Omae, T; Sawada, T, 1993) |
| "Long-acting nifedipine tablets were given to 47 severely and moderately hypertensive patients with renal insufficiency, cardiovascular, cerebrovascular, and peripheral vascular disease, diabetes mellitus, asthma, and systemic lupus erythematosus." | 3.67 | Long-acting nifedipine in moderate and severe hypertensive patients with serious concomitant diseases. ( Bursztyn, M; Grossman, E; Rosenthal, T, 1985) |
| " Two cases and a review of the literature relating to treatment of hypertensive emergencies with nifedipine are presented." | 3.67 | Nifedipine in the management of hypertensive emergencies: report of two cases and review of the literature. ( Checcio, LM; Cohan, JA, 1985) |
| "nilvadipine or terazosin was administered for 2 weeks in a randomized crossover manner." | 2.69 | Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke. ( Abe, I; Fujishima, M; Hasuo, Y; Nishino, Y; Onaka, U; Setoguchi, M, 1998) |
| " These differences can be attributed at least in part to the low catecholamine profile of verapamil and the marked rapid adrenergic activation with short-acting nifedipine, which could also explain the adverse effects found when this agent is given to patients with acute coronary syndromes." | 2.40 | Calcium channel blockers for hypertension: dissecting the evidence for adverse effects. ( Opie, LH, 1997) |
| "The drug is equally effective in treating hypertension in elderly and younger patients and does not appear to adversely affect glucose or lipid metabolism." | 2.39 | Nilvadipine. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic use in hypertension and potential in cerebrovascular disease and angina. ( Brogden, RN; McTavish, D, 1995) |
| "The development of Alzheimer's disease (AD) is generally thought to correlate with cerebral accumulation of Abeta." | 1.32 | Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice. ( Crawford, F; Crescentini, R; Humphrey, J; Mullan, M; Paris, D; Patel, N; Quadros, A, 2004) |
| "Hypertension was examined as an independent variable for its effect on patient outcome." | 1.29 | Case management in cerebral revascularization. ( Edwards, WH; Hoyle, RM; Jenkins, JM; Martin, RS; Mulherin, JL, 1994) |
| "Amlodipine is a long-acting dihydropyridine calcium antagonist with vascular selectivity." | 1.28 | Vascular and myocardial effects of amlodipine: an overview. ( Gu, XH; Nayler, WG, 1991) |
| " Chronic administration of YM-09730-5 (3 mg/kg) reduced the severity of glomerular lesions in the kidney and vasculitis in the mesenteric artery." | 1.28 | Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive rats. ( Fujimoto, K; Inagaki, O; Kawashima, K; Oohata, H; Suzuki, T; Toda, H, 1991) |
| " The dosage was 1." | 1.27 | Calcium antagonist (PY 108-068) treatment may further decrease flow in ischemic areas in acute stroke. ( Andersen, A; Blegvad, N; Paulson, OB; Vorstrup, S, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (31.25) | 18.7374 |
| 1990's | 31 (64.58) | 18.2507 |
| 2000's | 2 (4.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Payne, GW | 1 |
| Smeda, JS | 1 |
| Paris, D | 1 |
| Quadros, A | 1 |
| Humphrey, J | 1 |
| Patel, N | 1 |
| Crescentini, R | 1 |
| Crawford, F | 1 |
| Mullan, M | 1 |
| Ram, CV | 2 |
| Altura, BM | 1 |
| Altura, BT | 1 |
| Buscaino, GA | 1 |
| Tanne, D | 1 |
| Reicher-Reiss, H | 1 |
| Boyko, V | 1 |
| Behar, S | 1 |
| Brogden, RN | 1 |
| McTavish, D | 1 |
| Prattichizzo, FA | 1 |
| Galetta, F | 1 |
| Bonechi, I | 1 |
| Giusti, C | 1 |
| Akopov, SS | 1 |
| Grigorian, GS | 2 |
| Gabrielian, ES | 3 |
| Ashwal, S | 1 |
| Bedros, A | 1 |
| Thompson, J | 1 |
| Macfarlane, CR | 1 |
| Hoyle, RM | 1 |
| Jenkins, JM | 1 |
| Edwards, WH | 2 |
| Martin, RS | 1 |
| Mulherin, JL | 1 |
| Takakura, S | 1 |
| Furuichi, Y | 1 |
| Yamamoto, T | 1 |
| Ogawa, T | 1 |
| Satoh, H | 1 |
| Mori, J | 1 |
| Akopov, S | 1 |
| Grigorian, G | 1 |
| Gabrielian, E | 1 |
| Kuriyama, Y | 1 |
| Hashimoto, H | 1 |
| Nagatsuka, K | 1 |
| Sawada, T | 1 |
| Omae, T | 1 |
| Roine, RO | 1 |
| Gong, L | 1 |
| Zhang, W | 1 |
| Zhu, Y | 1 |
| Zhu, J | 1 |
| Kong, D | 1 |
| Pagé, V | 1 |
| Ghadirian, P | 1 |
| LeLorier, J | 1 |
| Hamet, P | 1 |
| Jiang, GC | 1 |
| Iwanov, V | 1 |
| Moulds, RF | 1 |
| Kim, S | 1 |
| Ohta, K | 1 |
| Hamaguchi, A | 1 |
| Miura, K | 1 |
| Yukimura, T | 1 |
| Iwao, H | 1 |
| Yokoyama, H | 1 |
| Tomonaga, O | 1 |
| Hirayama, M | 1 |
| Ishii, A | 1 |
| Takeda, M | 1 |
| Babazono, T | 1 |
| Ujihara, U | 1 |
| Takahashi, C | 1 |
| Omori, Y | 1 |
| Opie, LH | 1 |
| Takahashi, T | 1 |
| Tanikawa, S | 1 |
| Takahashi, K | 1 |
| Perez, I | 1 |
| Smithard, DG | 1 |
| Davies, H | 1 |
| Kalra, L | 1 |
| Głuszek, J | 1 |
| Pawlaczyk-Gabriel, K | 1 |
| Kloner, RA | 1 |
| Vetrovec, GW | 1 |
| Materson, BJ | 1 |
| Levenstein, M | 1 |
| Setoguchi, M | 1 |
| Onaka, U | 1 |
| Abe, I | 1 |
| Hasuo, Y | 1 |
| Nishino, Y | 1 |
| Fujishima, M | 1 |
| Schmitz, H | 1 |
| Schierl, W | 1 |
| Beck, O | 1 |
| Lydtin, H | 1 |
| Akopov, SE | 2 |
| Tunian, IuS | 2 |
| Messerli, FH | 1 |
| Kowey, P | 1 |
| Grodzicki, T | 1 |
| Gambhir, IS | 1 |
| Gupta, SS | 1 |
| Singh, DS | 1 |
| Nayler, WG | 2 |
| Gu, XH | 2 |
| Kawashima, K | 1 |
| Toda, H | 1 |
| Oohata, H | 1 |
| Fujimoto, K | 1 |
| Suzuki, T | 1 |
| Inagaki, O | 1 |
| Schwartz, M | 1 |
| Naschitz, JE | 1 |
| Yeshurun, D | 1 |
| Sharf, B | 1 |
| Liu, LS | 1 |
| Zhao, Y | 1 |
| Lei, YP | 1 |
| Wang, W | 1 |
| Zhang, XE | 1 |
| Jin, L | 1 |
| Martirosian, GR | 1 |
| Zhuravlev, AK | 1 |
| Murashko, VV | 1 |
| Kamchatnov, PR | 1 |
| Vorstrup, S | 1 |
| Andersen, A | 1 |
| Blegvad, N | 1 |
| Paulson, OB | 1 |
| del Ser, T | 1 |
| Bermejo, F | 1 |
| Gomara, S | 1 |
| Calandre, L | 1 |
| Vintró Molins, C | 1 |
| Viaplana Más, JM | 1 |
| Meese, RB | 1 |
| Shtok, VN | 1 |
| Eremeeva, SV | 1 |
| Bursztyn, M | 1 |
| Grossman, E | 1 |
| Rosenthal, T | 1 |
| Cohan, JA | 1 |
| Checcio, LM | 1 |
| Gascón Ramón, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A European Multicentre Double-blind Placebo-controlled Phase III Trial of Nilvadipine in Mild to Moderate Alzheimer's Disease[NCT02017340] | Phase 3 | 511 participants (Actual) | Interventional | 2013-04-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for nifedipine and Brain Vascular Disorders
| Article | Year |
|---|---|
Hypertensive crisis.
Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia | 1984 |
Microcirculatory actions and uses of naturally-occurring (magnesium) and novel synthetic calcium channel blockers.
Topics: Anesthesia; Animals; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Cell Membrane Pe | 1984 |
Nilvadipine. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic use in hypertension and potential in cerebrovascular disease and angina.
Topics: Aging; Angina Pectoris; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cerebrovascular | 1995 |
Calcium channel blockers for hypertension: dissecting the evidence for adverse effects.
Topics: Calcium Channel Blockers; Catecholamines; Cerebrovascular Disorders; Drug Evaluation; Gastrointestin | 1997 |
[Controversy about using calcium antagonists for treatment of coronary disease and hypertension].
Topics: Calcium Channel Blockers; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disease; Hum | 1997 |
Safety of long-acting dihydropyridine calcium channel blockers in hypertensive patients.
Topics: Amlodipine; Calcium Channel Blockers; Cause of Death; Cerebrovascular Disorders; Clinical Trials as | 1998 |
Hypertensive cardiovascular emergencies.
Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia | 1985 |
8 trials available for nifedipine and Brain Vascular Disorders
| Article | Year |
|---|---|
Stroke risk after anterior wall acute myocardial infarction. SPRINT Study Group. Secondary Prevention Reinfarction Israeli Nifedipine Trial.
Topics: Aged; Atrial Fibrillation; Cerebrovascular Disorders; Chronic Disease; Female; Follow-Up Studies; Hu | 1995 |
Shanghai trial of nifedipine in the elderly (STONE).
Topics: Aged; Arrhythmias, Cardiac; Calcium Channel Blockers; Cerebrovascular Disorders; Cohort Studies; Hum | 1996 |
Predictors of the progression of diabetic nephropathy and the beneficial effect of angiotensin-converting enzyme inhibitors in NIDDM patients.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel B | 1997 |
Pharmacological treatment of dysphagia in stroke.
Topics: Aged; Calcium Channel Blockers; Cerebrovascular Disorders; Deglutition Disorders; Double-Blind Metho | 1998 |
Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Aging; Blood Pressure Monitoring, Ambulatory; | 1998 |
[A prospective study on the effect of nifedipine of the cardiovascular complications in the elderly hypertensives].
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Cerebrovascular Disorders; Female; Humans; Hypertension | 1992 |
Sublingual nifedipine in hypertensive emergencies with special reference to cerebrovascular accident.
Topics: Administration, Sublingual; Blood Pressure; Cerebrovascular Disorders; Emergencies; Humans; Hyperten | 1991 |
[Parallel double-blind clinical trial of nifedipine versus a placebo in patients with chronic cerebrovascular insufficiency].
Topics: Cerebrovascular Disorders; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Humans; N | 1985 |
33 other studies available for nifedipine and Brain Vascular Disorders
| Article | Year |
|---|---|
Cerebrovascular alterations in pressure and protein kinase C-mediated constriction in Dahl salt-sensitive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; Disease Models, Animal | 2002 |
Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Aorta; Calcium Channel B | 2004 |
[Medical treatment of acute disorders of cerebral circulation].
Topics: Aminophylline; Anticoagulants; Antihypertensive Agents; Brain Edema; Cerebrovascular Disorders; Cinn | 1980 |
[Therapy of arterial hypertension associated with acute stroke. Current trends and problems].
Topics: Acute Disease; Aged; Antihypertensive Agents; Blood Pressure Monitors; Cerebral Hemorrhage; Cerebrov | 1994 |
Dynamic component of internal carotid artery stenosis in patients with cerebrovascular disease: effects of nifedipine.
Topics: Aged; Blood Flow Velocity; Carotid Artery, Internal; Carotid Stenosis; Cerebrovascular Circulation; | 1994 |
Nifedipine increases cerebral blood flow in sickle cell disease: a case study.
Topics: Adolescent; Anemia, Sickle Cell; Cerebrovascular Circulation; Cerebrovascular Disorders; Hemiplegia; | 1994 |
Treating hypertension after stroke.
Topics: Administration, Oral; Cerebrovascular Disorders; Deglutition; Humans; Hypertension; Nifedipine | 1994 |
Case management in cerebral revascularization.
Topics: Aged; Aged, 80 and over; Angioplasty; Blood Vessel Prosthesis; Cerebral Revascularization; Cerebrova | 1994 |
Effect of nilvadipine on the development of neurological deficits in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Calcium Channel Blockers; Cerebrovascular Disorders; Eating; Hypertension; Male; Nifedipine | 1994 |
Noninvasive testing of dynamic component of internal carotid artery stenosis in patients with chronic cerebrovascular disease.
Topics: Brain; Carotid Artery, Common; Carotid Artery, Internal; Carotid Stenosis; Cerebrovascular Disorders | 1994 |
Effects of dihydropyridines on cerebral blood vessels.
Topics: Administration, Oral; Blood Pressure; Cerebral Infarction; Cerebrovascular Circulation; Cerebrovascu | 1993 |
Nimodipine in patients with heart disease.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Cerebrovascular Disorders; Clinical Trials as Top | 1996 |
Relationship between nifedipine sensitivity of aortae and blood pressure of stroke-prone spontaneously hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Cerebrovascular Disorders; Hypertension; In Vitro Techniques; Male; | 1996 |
Suppression of vascular transforming growth factor-beta1 and extracellular matrix gene expressions by cilazapril and nifedipine in hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Autoradiography; Blood Vessels; Blotting, Norther | 1995 |
Protective effects of CD-832 on organ damage in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Cerebrovascular Disorders; Diltiazem | 1997 |
Early management of acute stroke in emergency departments: preliminary findings. Florida Medical Quality Assurance, Inc.
Topics: Acute Disease; Blood Pressure; Cerebrovascular Disorders; Cross-Sectional Studies; Electrocardiograp | 1998 |
[Proceedings: Effect of Nifedipine on the regional cerebral and peripheral muscle circulation].
Topics: Angina Pectoris; Cerebrovascular Circulation; Cerebrovascular Disorders; Humans; Muscles; Nifedipine | 1975 |
[Pharmacodynamic approach to the optimal use of calcium antagonists in patients with cerebrovascular disorders].
Topics: Aged; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Erythrocyte Aggregation; Humans; | 1991 |
Sublingual nifedipine for hypertensive emergencies.
Topics: Administration, Sublingual; Cerebrovascular Disorders; Contraindications; Emergencies; Humans; Hyper | 1991 |
Vascular and myocardial effects of amlodipine: an overview.
Topics: Amlodipine; Animals; Arteriosclerosis; Binding Sites; Calcium Channel Blockers; Cardiomegaly; Cerebr | 1991 |
Treatment of hypertensive crisis.
Topics: Antihypertensive Agents; Cerebrovascular Disorders; Emergencies; Humans; Hypertension; Nifedipine; N | 1991 |
Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorder | 1991 |
Protecting the vasculature: an eye toward the future.
Topics: Amlodipine; Animals; Arteries; Arteriosclerosis; Blood Pressure; Calcium Channel Blockers; Cerebrova | 1990 |
Oral nifedipine in the treatment of hypertensive urgency: cerebrovascular accident following a single dose.
Topics: Adult; Cerebrovascular Disorders; Humans; Hypertension; Male; Nifedipine | 1990 |
Calcium antagonists in prevention of hypertension and stroke in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Calcium Channel Blockers; Cerebrovascular Disorders; Female; Hypertension; Male; Nifedipine | 1989 |
[Blood cells and their sensitivity to calcium antagonists in patients with cerebrovascular disorders].
Topics: Adult; Aged; Blood Cells; Blood Platelets; Calcium Channel Blockers; Cerebrovascular Disorders; Drug | 1989 |
[Effect of corinfar and finoptin on lipid peroxidation].
Topics: Adult; Calcium Channel Blockers; Cerebrovascular Disorders; Humans; Lipid Peroxides; Middle Aged; My | 1988 |
Calcium antagonist (PY 108-068) treatment may further decrease flow in ischemic areas in acute stroke.
Topics: Acute Disease; Adult; Aged; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circula | 1986 |
[Does nicardipine improve chronic cerebrovascular insufficiency?].
Topics: Cerebrovascular Disorders; Humans; Nicardipine; Nifedipine; Vasodilator Agents | 1986 |
[Effect of nifedipine (adalate) in neurology patients with arterial hypertension].
Topics: Adult; Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Female; Humans | 1985 |
Long-acting nifedipine in moderate and severe hypertensive patients with serious concomitant diseases.
Topics: Adult; Aged; Angina Pectoris; Asthma; Cerebrovascular Disorders; Diabetes Complications; Edema; Fema | 1985 |
Nifedipine in the management of hypertensive emergencies: report of two cases and review of the literature.
Topics: Administration, Oral; Aged; Blood Pressure; Cardiac Output; Cerebrovascular Disorders; Emergencies; | 1985 |
[Chronic cerebral vascular pathology].
Topics: Age Factors; Brain Diseases; Cerebrovascular Disorders; Diagnosis, Differential; Humans; Nicardipine | 1985 |