nifedipine has been researched along with Aura in 27 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topiramate (TPM), a new generation antiepileptic drug was investigated for its anticonvulsant effects in various models of genetically determined and chemically induced epilepsy in rodents." | 7.72 | Nifedipine affects the anticonvulsant activity of topiramate in various animal models of epilepsy. ( Citraro, R; Constanti, A; De Sarro, G; Ferreri, G; Russo, E, 2004) |
| "The authors report the use of nifedipine as a coadjuvant drug in the treatment of three patients with uncontrolled epilepsy." | 7.67 | [Nifedipine as a coadjuvant drug in the treatment of uncontrolled epilepsy: a preliminary report]. ( Lago, IS; Ohlweiler, L; Rotta, NT, 1989) |
| " Similarly, there is no convincing evidence to support the use of nifedipine or nimodipine as add-on treatments for epilepsy." | 4.89 | Calcium antagonists as an add-on therapy for drug-resistant epilepsy. ( Hasan, M; Marson, AG; Pulman, J, 2013) |
| " Similarly, there is no convincing evidence to support the use of nifedipine or nimodipine as add-on treatments for epilepsy." | 4.81 | Calcium antagonists as an add-on therapy for drug-resistant epilepsy. ( Baillie, N; Chaisewikul, R; Marson, AG, 2001) |
| "Levetiracetam (LEV) is a widely used antiepileptic agent for partial refractory epilepsy in humans." | 3.79 | Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca²⁺ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER). ( Arita, K; Hanaya, R; Ishihara, K; Kurisu, K; Sasa, M; Seki, T; Serikawa, T; Yan, HD, 2013) |
| "Topiramate (TPM), a new generation antiepileptic drug was investigated for its anticonvulsant effects in various models of genetically determined and chemically induced epilepsy in rodents." | 3.72 | Nifedipine affects the anticonvulsant activity of topiramate in various animal models of epilepsy. ( Citraro, R; Constanti, A; De Sarro, G; Ferreri, G; Russo, E, 2004) |
| "Carbamazepine (CBZ) is widely used in the treatment of epilepsy." | 3.70 | Metabolism of carbamazepine by CYP3A6: a model for in vitro drug interactions studies. ( Barra, Y; Bourgarel-Rey, V; Charvet, B; Desobry, A; Mesdjian, E; Mirrione, A; Sérée, E, 1999) |
| "The aim of the present investigation was to compare the antiepileptic efficacy of the specific L-type calcium channel blocker nifedipine in hippocampal and neocortical slice preparations in the Mg2+-free model of epilepsy." | 3.70 | Contribution of L-type calcium channels to epileptiform activity in hippocampal and neocortical slices of guinea-pigs. ( Frieler, A; Grigat, M; Köhling, R; Speckmann, EJ; Straub, H, 2000) |
| " The paper addresses this question by exploring the antiepileptic efficacy of the L-type calcium channel blockers verapamil and nifedipine in low-Mg(2+)-epilepsy in rat hippocampal slices of different postnatal (PN) ages." | 3.70 | Differential involvement of L-type calcium channels in epileptogenesis of rat hippocampal slices during ontogenesis. ( Köhling, R; Speckmann, EJ; Straub, H, 2000) |
| "The antiepileptic effect of the dihydropyridine calcium channel blocker nifedipine was tested in neocortical slice preparations (n=27) from patients ranging in age from four to 46 years (mean=25) who underwent surgery for the treatment of intractable epilepsy." | 3.70 | Effects of nifedipine on rhythmic synchronous activity of human neocortical slices. ( Ebner, A; Höhling, JM; Köhling, R; Lücke, A; Oppel, F; Pannek, H; Speckmann, EJ; Straub, H; Tuxhorn, I; Wolf, P, 2000) |
| "The authors report the use of nifedipine as a coadjuvant drug in the treatment of three patients with uncontrolled epilepsy." | 3.67 | [Nifedipine as a coadjuvant drug in the treatment of uncontrolled epilepsy: a preliminary report]. ( Lago, IS; Ohlweiler, L; Rotta, NT, 1989) |
| "Nifedipine is an L-type voltage-dependent calcium channel blocker." | 1.40 | Effect of nifedipine on hippocampal neuron number in penicillin-induced epileptic rats. ( Akdogan, I; Kaya, E; Yilmaz, I; Yonguc, GN, 2014) |
| "The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s." | 1.29 | Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. ( Satishchandra, P; Shankar, SK; Ullal, GR, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Hasan, M | 1 |
| Pulman, J | 1 |
| Marson, AG | 2 |
| Yilmaz, I | 1 |
| Akdogan, I | 1 |
| Kaya, E | 1 |
| Yonguc, GN | 1 |
| Yan, HD | 1 |
| Ishihara, K | 2 |
| Seki, T | 1 |
| Hanaya, R | 1 |
| Kurisu, K | 1 |
| Arita, K | 1 |
| Serikawa, T | 2 |
| Sasa, M | 2 |
| Gorji, A | 2 |
| Moddel, G | 1 |
| Speckmann, EJ | 5 |
| El-Abhar, HS | 1 |
| El Gawad, HM | 1 |
| Russo, E | 1 |
| Constanti, A | 1 |
| Ferreri, G | 1 |
| Citraro, R | 1 |
| De Sarro, G | 1 |
| Rüschenschmidt, C | 1 |
| Straub, H | 4 |
| Köhling, R | 4 |
| Siep, E | 1 |
| Galanopoulou, AS | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Karpova, MN | 2 |
| Abrosimov, IIu | 1 |
| Pankov, OIu | 2 |
| Lakinina, MV | 1 |
| Ullal, GR | 2 |
| Satishchandra, P | 1 |
| Shankar, SK | 1 |
| DeLorenzo, RJ | 1 |
| Pal, S | 1 |
| Sombati, S | 1 |
| Mesdjian, E | 1 |
| Sérée, E | 1 |
| Charvet, B | 1 |
| Mirrione, A | 1 |
| Bourgarel-Rey, V | 1 |
| Desobry, A | 1 |
| Barra, Y | 1 |
| Frieler, A | 1 |
| Grigat, M | 1 |
| Höhling, JM | 1 |
| Lücke, A | 1 |
| Tuxhorn, I | 1 |
| Ebner, A | 1 |
| Wolf, P | 1 |
| Pannek, H | 1 |
| Oppel, F | 1 |
| Amano, H | 1 |
| Amano, T | 1 |
| Matsubayashi, H | 1 |
| Jacome, DE | 1 |
| Chaisewikul, R | 1 |
| Baillie, N | 1 |
| Lukyanetz, EA | 1 |
| Shkryl, VM | 1 |
| Kostyuk, PG | 1 |
| Gavranovic, M | 1 |
| Müller, T | 1 |
| Sofic, E | 1 |
| Bilalbegovic, Z | 1 |
| Glebov, RN | 1 |
| Germane, SK | 1 |
| Klusha, VE | 1 |
| Dubur, GIa | 1 |
| Rotta, NT | 1 |
| Ohlweiler, L | 1 |
| Lago, IS | 1 |
| Larkin, JG | 1 |
| Butler, E | 1 |
| Brodie, MJ | 1 |
| Wen, P | 1 |
| Frank, C | 1 |
| Sagratella, S | 1 |
| Benedetti, M | 1 |
| Scotti de Carolis, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687] | 46 participants (Actual) | Interventional | 2008-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period
| Intervention | number of drinks per treatment period (Mean) |
|---|---|
| All Subjects (n = 46) Placebo | 41.2 |
| All Subjects (n = 46) Levetiracetam | 45.4 |
4 reviews available for nifedipine and Aura
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Calcium antagonists as an add-on therapy for drug-resistant epilepsy.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Resistance; Drug Therapy, Combination; Epilepsy; Flu | 2013 |
GABA receptors as broadcasters of sexually differentiating signals in the brain.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Epilepsy; Female; Gene Expression Regulation, D | 2005 |
Calcium antagonists as an add-on therapy for drug-resistant epilepsy.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Resistance; Epilepsy; Flunarizine; Humans; Nifedipin | 2001 |
1 trial available for nifedipine and Aura
| Article | Year |
|---|---|
Anticonvulsants combined with nifedipine for epilepsy in adults.
Topics: Adolescent; Adult; Ambulatory Care; Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; | 1991 |
22 other studies available for nifedipine and Aura
| Article | Year |
|---|---|
Effect of nifedipine on hippocampal neuron number in penicillin-induced epileptic rats.
Topics: Animals; Calcium Channel Blockers; Cell Survival; Cerebral Cortex; Disease Models, Animal; Epilepsy; | 2014 |
Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca²⁺ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER).
Topics: Animals; Anticonvulsants; Biophysics; Calcium; Calcium Channel Blockers; Dose-Response Relationship, | 2013 |
Background potassium concentrations and epileptiform discharges. II. Involvement of calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Epilepsy; Extracellular Space; Female; | 2003 |
Modulation of cortical nitric oxide synthase, glutamate, and redox state by nifedipine and taurine in PTZ-kindled mice.
Topics: Animals; Anticonvulsants; Antioxidants; Calcium; Calcium Channel Blockers; Cerebral Cortex; Dose-Res | 2003 |
Nifedipine affects the anticonvulsant activity of topiramate in various animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction | 2004 |
Reduction of human neocortical and guinea pig CA1-neuron A-type currents by organic calcium channel blockers.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Animals; Calcium Channel Blockers; Child; Epilepsy; Fem | 2004 |
[Anticonvulsant activity of sodium valproate and various calcium antagonists during their combined use in mice].
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combi | 1993 |
Dihydropyridine group of calcium channel antagonist in epilepsy.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electrodes, Implanted; Electroencephalography; | 1994 |
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electr | 1996 |
Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzoates; Calcium; Cells, Cultured; Dizocil | 1998 |
Metabolism of carbamazepine by CYP3A6: a model for in vitro drug interactions studies.
Topics: Animals; Anti-Bacterial Agents; Antibodies; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Biotrans | 1999 |
Contribution of L-type calcium channels to epileptiform activity in hippocampal and neocortical slices of guinea-pigs.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Epile | 2000 |
Differential involvement of L-type calcium channels in epileptogenesis of rat hippocampal slices during ontogenesis.
Topics: Age Factors; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Epilepsy | 2000 |
Effects of nifedipine on rhythmic synchronous activity of human neocortical slices.
Topics: Adolescent; Bicuculline; Calcium Channel Blockers; Child; Child, Preschool; Convulsants; Dose-Respon | 2000 |
Enhanced calcium influx in hippocampal CA3 neurons of spontaneously epileptic rats.
Topics: Animals; Calcium; Calcium Channels; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationshi | 2001 |
Exploding head syndrome and idiopathic stabbing headache relieved by nifedipine.
Topics: Aged; Anxiety Disorders; Calcium Channel Blockers; Calcium Channels; Diagnosis, Differential; Electr | 2001 |
Selective blockade of N-type calcium channels by levetiracetam.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Calcium Channels, N-Type; Dose-Response Relation | 2002 |
[Effect of a Ca-channel blocker, ryodipine, on focal and generalized epileptic activity].
Topics: Animals; Calcium Channel Blockers; Epilepsies, Partial; Epilepsy; Male; Nifedipine; Pentylenetetrazo | 1989 |
[Nifedipine as a coadjuvant drug in the treatment of uncontrolled epilepsy: a preliminary report].
Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Nifedipine | 1989 |
Nifedipine for epilepsy? A pilot study.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Nife | 1988 |
Nifedipine for epilepsy?
Topics: Epilepsy; Humans; Nifedipine | 1988 |
Comparative influence of calcium blocker and purinergic drugs on epileptiform bursting in rat hippocampal slices.
Topics: Adenosine; Animals; Caffeine; Calcium; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male; | 1988 |