Page last updated: 2024-11-01

nifedipine and Asystole

nifedipine has been researched along with Asystole in 13 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Research Excerpts

ExcerptRelevanceReference
"The results suggest that exposure to nifedipine in human pregnancy 3-4 weeks postfertilization may cause a direct effect on the embryonic heart resulting in reduced blood flow leading to abnormal heart and/or blood vessel development and/or embryonic death."7.91The effects of nifedipine and ivabradine on the functionality of the early rat embryonic heart. Are these drugs a risk in early human pregnancy? ( Gustaffson, E; Ritchie, HE; Telenius, C; Webster, WS, 2019)
"Before cardiac arrest, 10 animals were randomly assigned to receive either nifedipine (0."5.32The effects of nifedipine on ventricular fibrillation mean frequency in a porcine model of prolonged cardiopulmonary resuscitation. ( Amann, A; Augenstein, S; Krismer, AC; Lindner, KH; Raedler, C; Rheinberger, K; Stadlbauer, KH; Strohmenger, HU; Voelckel, WG; Wagner-Berger, HG; Wenzel, V, 2003)
"The results suggest that exposure to nifedipine in human pregnancy 3-4 weeks postfertilization may cause a direct effect on the embryonic heart resulting in reduced blood flow leading to abnormal heart and/or blood vessel development and/or embryonic death."3.91The effects of nifedipine and ivabradine on the functionality of the early rat embryonic heart. Are these drugs a risk in early human pregnancy? ( Gustaffson, E; Ritchie, HE; Telenius, C; Webster, WS, 2019)
"Before cardiac arrest, 10 animals were randomly assigned to receive either nifedipine (0."1.32The effects of nifedipine on ventricular fibrillation mean frequency in a porcine model of prolonged cardiopulmonary resuscitation. ( Amann, A; Augenstein, S; Krismer, AC; Lindner, KH; Raedler, C; Rheinberger, K; Stadlbauer, KH; Strohmenger, HU; Voelckel, WG; Wagner-Berger, HG; Wenzel, V, 2003)
"An incident is reported in which 2 intravenous drug abusers died as the result of uncontrolled experimentation with intravenous injection of the common anti-hypertensive and anti-anginal drug Nifedipine (Adalat t."1.28Two deaths from intravenous nifedipine abuse. ( Busuttil, A; Fernando, GC; Purdue, BN, 1991)
"Using the cardiac arrest and resuscitation model of de Garavilla, Babbs, and Tacker with an arrest time of eight minutes, 76% of the animals arrested were resuscitated with an average intermittent abdominal compression-CPR time of 3."1.27Effect of nifedipine on cerebral high-energy phosphates after cardiac arrest and resuscitation in the rat. ( Fillipo, DC; Garrison, HG; Hansen, AR; Palladino, GW; Proctor, HJ, 1986)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19906 (46.15)18.7374
1990's5 (38.46)18.2507
2000's1 (7.69)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ritchie, HE1
Telenius, C1
Gustaffson, E1
Webster, WS1
Stadlbauer, KH1
Rheinberger, K1
Wenzel, V1
Raedler, C1
Krismer, AC1
Strohmenger, HU1
Augenstein, S1
Wagner-Berger, HG1
Voelckel, WG1
Lindner, KH1
Amann, A1
Farber, HW1
Karlinsky, JB1
Faling, LJ1
Kopf, GS1
Riba, A1
Zito, R1
Frierson, JH1
Bigelow, JC1
Duke, DJ1
Mahoney, TM1
Dimas, AP1
Weston, CF1
Tigg, A1
Griffiths, BE1
Vara, J1
Alvarez, G1
Lambert, JL1
Espolita, A1
Rubín, JM1
Posada, IS1
Cortina, A1
Morís, C1
Purdue, BN1
Fernando, GC1
Busuttil, A1
Kawakage, M1
Shirakura, S1
Karasawa, A1
Takeda, M1
Miki, I1
Ishii, A1
Kubo, K1
Shettigar, UR1
Loungani, R1
Plotkin, CN1
Eckenbrecht, PD1
Waldo, DA1
Wells, DG1
Zelcer, J1
Treadrae, C1
Garrison, HG1
Hansen, AR1
Palladino, GW1
Fillipo, DC1
Proctor, HJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Calcium Channel Blockers in Nitric Oxide Non-responder Pulmonary Arterial Hypertension.[NCT01645826]0 participants (Actual)Interventional2012-07-31Withdrawn (stopped due to no participants agreed to enroll since study start)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for nifedipine and Asystole

ArticleYear
Pre-hospital cardiac arrest associated with coronary artery spasm.
    International journal of cardiology, 1993, Volume: 38, Issue:1

    Topics: Adult; Cardiac Catheterization; Coronary Angiography; Coronary Vasospasm; Echocardiography; Ergonovi

1993

Other Studies

12 other studies available for nifedipine and Asystole

ArticleYear
The effects of nifedipine and ivabradine on the functionality of the early rat embryonic heart. Are these drugs a risk in early human pregnancy?
    Birth defects research, 2019, 03-15, Volume: 111, Issue:5

    Topics: Animals; Female; Heart; Heart Arrest; Heart Rate; Humans; Ivabradine; Nifedipine; Pregnancy; Rats; R

2019
The effects of nifedipine on ventricular fibrillation mean frequency in a porcine model of prolonged cardiopulmonary resuscitation.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:1

    Topics: Animals; Calcium Channel Blockers; Cardiopulmonary Resuscitation; Coronary Circulation; Electrocardi

2003
Fatal outcome following nifedipine for pulmonary hypertension.
    Chest, 1983, Volume: 83, Issue:4

    Topics: Calcium Channel Blockers; Heart Arrest; Humans; Hypertension, Pulmonary; Male; Middle Aged; Nifedipi

1983
Intraoperative use of nifedipine for hemodynamic collapse due to coronary artery spasm following myocardial revascularization.
    The Annals of thoracic surgery, 1982, Volume: 34, Issue:4

    Topics: Coronary Vasospasm; Heart Arrest; Heart Rate; Hemodynamics; Humans; Hypotension; Intraoperative Comp

1982
Treatment of perioperative mammary artery graft spasm with nifedipine.
    American heart journal, 1993, Volume: 125, Issue:3

    Topics: Aged; Female; Graft Occlusion, Vascular; Heart Arrest; Humans; Internal Mammary-Coronary Artery Anas

1993
[Coronary spasm and heart arrest caused by ventricular fibrillation].
    Revista espanola de cardiologia, 1998, Volume: 51, Issue:5

    Topics: Adult; Calcium Channel Blockers; Coronary Angiography; Coronary Vasospasm; Electrocardiography, Ambu

1998
Two deaths from intravenous nifedipine abuse.
    International journal of legal medicine, 1991, Volume: 104, Issue:5

    Topics: Adult; Autopsy; Cardiopulmonary Resuscitation; Chromatography, Gas; Drug Overdose; Forensic Medicine

1991
Beneficial effect of the novel thromboxane A2 receptor antagonist sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)ethylidene]-6,11- dihydrodibenz[b,e]oxepine-2-carboxylate monohydrate on collagen-induced coronary ischemia in guinea-pigs.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:12

    Topics: Animals; Arrhythmias, Cardiac; Benzimidazoles; Benzoxepins; Collagen; Coronary Disease; Cyclooxygena

1991
Adverse effects of sublingual nifedipine in acute myocardial infarction.
    Critical care medicine, 1989, Volume: 17, Issue:2

    Topics: Administration, Sublingual; Chest Pain; Heart Arrest; Humans; Hypotension; Male; Middle Aged; Myocar

1989
Consecutive cardiac arrests on induction of anesthesia associated with nifedipine-induced carotid sinus hypersensitivity.
    Anesthesia and analgesia, 1989, Volume: 68, Issue:3

    Topics: Anesthesia, General; Carotid Sinus; Female; Heart Arrest; Humans; Middle Aged; Nifedipine

1989
ECT-induced asystole from a sub-convulsive shock.
    Anaesthesia and intensive care, 1988, Volume: 16, Issue:3

    Topics: Aged; Anesthesia, Intravenous; Arrhythmias, Cardiac; Atropine; Electroconvulsive Therapy; Heart Arre

1988
Effect of nifedipine on cerebral high-energy phosphates after cardiac arrest and resuscitation in the rat.
    Annals of emergency medicine, 1986, Volume: 15, Issue:6

    Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain; Carbon Dioxide; Heart Arrest; Heart Arrest,

1986