Page last updated: 2024-11-01

nifedipine and Arteriosclerosis

nifedipine has been researched along with Arteriosclerosis in 86 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.

Research Excerpts

ExcerptRelevanceReference
" The International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT) is the first, large, randomized, double-blind study undertaken exclusively in high-risk hypertensive patients, with CV events as a prospectively defined primary end-point."4.81Long-term protection in at-risk hypertensive patients--a role for nifedipine GITS? ( Ruilope, LM, 2002)
"We studied 34 older, nonsmoking patients (mean age 74 +/- 5 years) with uncomplicated hypertension before and after the normalization of blood pressure (BP) was achieved with the angiotensin-converting enzyme inhibitor quinapril alone or in combination with the Ca2+ antagonist nifedipine."3.70Platelet hyperactivity in hypertensive older patients is controlled by lowering blood pressure. ( Di Veroli, C; Gazzaniga, PP; Lenti, L; Marigliano, V; Pignatelli, P; Pulcinelli, FM; Riondino, S, 1999)
" The atherogenic significance of Ca ions and arterial Ca overload was examined under the influence of nicotine, oxidatively modified low-density lipoproteins, spontaneous hypertension, and an elevated extracellular Ca concentration or vitamin D3."3.69Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations. ( Czirfuzs, A; Fleckenstein-Grün, G; Frey, M; Matyas, S; Thimm, F, 1994)
"We compared the effect of two different calcium channel blockers (CCB), Nifedipine (1,4-dihydropyridine calcium antagonist) and Diltiazem (a benzothiazepine agent) on plasma components and the development of atherosclerotic plaque in experimental hypercholesterolemia."3.69Differential effect of two calcium channel blockers--nifedipine and diltiazem--on atherogenesis in hypercholesterolemic hamster. ( Pojoga, L; Raicu, M; Simionescu, M; Simionescu, N, 1996)
"The effect of nicardipine on experimental hyperlipemia induced by a 1% cholesterol diet in spontaneously hypertensive rats (SHR) was investigated by the change of hemodynamics and the determination of lipid contents of the serum, liver, heart and aorta."3.67[Effect of nicardipine on cholesterol-fed S.H.R]. ( Kawashima, I; Nakayama, S; Ohba, T; Sakamoto, K; Tonooka, M; Yasuhara, H, 1985)
"Nifedipine was administered to 47 patients for 2 years, and the change of PWV was compared with age-matched control hemodialysis patients."2.67Effect of nifedipine administration on pulse wave velocity (PWV) of chronic hemodialysis patients--2-year trial. ( Hattori, Y; Okazawa, M; Saito, Y; Shirai, K; Uchino, J; Yoshida, S; Yoshida, T, 1990)
"Hypertension and hypercholesterolemia are frequently associated, and their treatment is proven to reduce cardiovascular risk."2.42Combined antihypertensive and lipid-lowering treatment. ( Cesari, M; Pessina, AC, 2004)
" Current data suggest that only early stages of coronary atheromatosis may be affected by treatment with calcium antagonists; however, optimum drug, dosage and suitable patients are yet to be defined."2.38Can the coronary atherosclerotic process be influenced by calcium antagonists? ( Cieslinski, G; Kaltenbach, M; Kober, G; Schneider, W, 1992)
" The higher the dosage used, the higher the regression of the atherosclerotic lesions."1.32Planimetric and histological study of the aortae in atherosclerotic chickens treated with nifedipine, verapamil and diltiazem. ( Ayala, I; Ballesta, J; Castells, MT; Fernández Pardo, J; García Pérez, B; Madrid, JF; Ortega, JV; Ortega, MR; Valdés, M, 2003)
"Nifedipine group (N) were fed 1% cholesterol chow and nifedipine 40 mg/animal/day."1.29[An experimental study on the mechanism of antiatherosclerotic effect of nifedipine]. ( Xu, ZC, 1993)
"Concomitantly, cardiac hypertrophy was attenuated in the treated group compared with the placebo group (heart-to-body weight ratios of 4."1.28Vascular injury: mechanisms and manifestations. ( Nayler, WG, 1991)
"Amlodipine is a long-acting dihydropyridine calcium antagonist with vascular selectivity."1.28Vascular and myocardial effects of amlodipine: an overview. ( Gu, XH; Nayler, WG, 1991)
" The log dose-response relationship of S."1.28Quantitative analysis of antiatherosclerotic effect of nifedipine in cholesterol-fed rabbits. ( Emura, S; Higuchi, N; Kato, H; Ohmori, K; Ohta, Y; Oogushi, K; Sunaga, T; Takashima, T, 1990)
" It is concluded that an antihypertensive dosage of nifedipine administered to animals with atherosclerosis does not suppress subsequent atherogenesis."1.27Hypertension and atherosclerosis in cholesterol-fed rabbits. II. One-kidney, one clip Goldblatt hypertension treated with nifedipine. ( Overturf, M; Schaper, J; Sybers, H; Taegtmeyer, H, 1987)
"Nifedipine has been implicated as an inhibitor of dietary induced atherosclerosis in rabbits."1.27The beneficial influence of nifedipine on the regression of the cholesterol-induced atherosclerosis in rabbits. ( Niedmann, PD; Seidel, D; Thiery, J, 1987)
"Nifedipine was well tolerated, and evoked only transient, moderate reductions in arterial pressure."1.26Suppression of atherogenesis in cholesterol-fed rabbit treated with nifedipine. ( Bentley, KI; Henry, PD, 1981)

Research

Studies (86)

TimeframeStudies, this research(%)All Research%
pre-199038 (44.19)18.7374
1990's38 (44.19)18.2507
2000's10 (11.63)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Simon, A1
Levenson, J1
Samra, SS1
Walwaikar, PP1
Morye, VK1
Gawde, AG1
García Pérez, B1
Ayala, I1
Castells, MT1
Madrid, JF1
Ortega, MR1
Ortega, JV1
Ballesta, J1
Fernández Pardo, J1
Valdés, M1
Cesari, M1
Pessina, AC1
Iwasaki, Y1
Asai, M1
Yoshida, M1
Nigawara, T1
Kambayashi, M1
Oiso, Y1
Nakashima, N1
Yoshida, D1
Higashiura, K1
Shimamoto, K1
Yamagishi, S1
Takeuchi, M1
Komuro, I1
Stone, KS1
Scordo, KA1
Beinart, C1
Sos, TA1
Saddekni, S1
Weiner, MA1
Sniderman, KW1
Rouleau, JL1
Parmley, WW2
Stevens, J1
Wikman-Coffelt, J1
Sievers, R2
Mahley, RW1
Havel, RJ1
Bertrand, ME1
Lablanche, JM1
Tilmant, PY1
Thieuleux, FA1
Naito, M1
Kuzuya, F1
Asai, K1
Shibata, K1
Yoshimine, N1
Van Niekerk, JL1
Hendriks, T1
De Boer, HH1
Van 't Laar, A1
Williams, DO1
Lorentsen, E1
Landmark, K1
Henry, PD2
Bentley, KI1
Pauletto, P1
Da Ros, S1
Zoleo, M1
Rafflenbeul, W3
Mizushige, K1
DeMaria, AN1
Matsuo, H1
Fleckenstein-Grün, G2
Thimm, F1
Czirfuzs, A1
Matyas, S1
Frey, M2
Takahashi, T1
Tanaka, N1
Tomochika, Y1
Wasaki, Y1
Tone, T1
Shimizu, H1
Matsuzaki, H1
Matsuzaki, M1
Porta, R1
Conz, A1
Conto, A1
Pescador, R1
Mantovani, M1
Ferro, L1
Xu, ZC1
Akopov, SE3
Gabrielian, ES3
Alexander, JJ1
Miguel, R1
Piotrowski, JJ1
Raicu, M1
Pojoga, L1
Simionescu, N1
Simionescu, M1
Haller, H1
Weber, KT1
Feuerstein, GZ1
Fisher, M1
Nunnart, J1
Ruffolo, RR1
Pitt, B1
Kanayasu-Toyoda, T1
Morita, I1
Murota, S1
Sasaki, R1
Hirota, K1
Masuda, A1
Riondino, S1
Pignatelli, P1
Pulcinelli, FM1
Lenti, L1
Di Veroli, C1
Marigliano, V1
Gazzaniga, PP1
Porcellini, M1
Elia, S1
Camera, L1
Bracale, G1
Inouye, M1
Mio, T1
Sumino, K1
Ruilope, LM1
Pola, P1
Savi, L2
Kober, G1
Schneider, W1
Cieslinski, G1
Kaltenbach, M1
Edelsteinová, S2
Bohov, P1
Lazarová, Z2
Inczinger, F1
Nayler, WG6
Qin, S1
Lojda, Z1
Holub, P1
Mrázková, O1
Orekhov, AN2
Tertov, VV1
Lyakishev, AA1
Gu, XH2
Zhang, Y1
Ghazarian, AV1
Ohta, Y1
Higuchi, N1
Emura, S1
Takashima, T1
Oogushi, K1
Kato, H1
Ohmori, K1
Sunaga, T1
Knorr, AM1
Kazda, S1
Liu, JJ1
Panagiotopoulos, S1
Saito, Y1
Shirai, K1
Uchino, J1
Okazawa, M1
Hattori, Y1
Yoshida, T1
Yoshida, S1
Orimo, H2
Ouchi, Y1
Atkinson, JB1
Swift, LL1
Weiss, K1
Fitscha, P1
Gazsó, A1
Gludovacz, D1
Sinzinger, H1
Fleckenstein, A2
Zorn, J1
Koibuchi, Y1
Sakai, S1
Miura, S1
Ono, T1
Shibayama, F1
Ohtsuka, M1
Jackson, CL1
Bush, RC1
Bowyer, DE1
Seuter, F1
Lichtor, T1
Davis, HR1
Vesselinovitch, D1
Wissler, RW1
Mullan, S1
Jennings, WC1
Corder, CN1
Jarolim, DR1
Blackwell, J1
Cherian, J1
Chen, D1
Handley, DA1
Van Valen, RG1
Melden, MK1
Saunders, RN1
Nilsson, J1
Sjölund, M1
Palmberg, L1
Von Euler, AM1
Jonzon, B1
Thyberg, J1
Lichtlen, PR1
Nellessen, U1
Jost, S1
Hecker, H1
Mori, S1
Ito, H1
Yamamoto, K1
Mutoh, S2
Nomoto, A2
Sekiguchi, C2
Yamaguchi, I2
Overturf, M1
Sybers, H1
Schaper, J1
Taegtmeyer, H1
Thiery, J1
Niedmann, PD1
Seidel, D1
Larach, DR1
Zelis, R1
Overturf, ML1
Smith, SA1
Hugenholtz, PG1
Lichtlen, P1
van der Giessen, W1
Becker, AE1
Hülsmann, WC1
Ahn, YS1
Jy, W1
Harrington, WJ1
Shanbaky, N1
Fernandez, LF1
Haynes, DH1
Ishikawa, Y2
Watanabe, N2
Okamoto, R2
Watanabe, Y2
Fukuzaki, H2
Hirosumi, J1
Aoki, H1
Fuchs, U1
Fuchs, M1
Hartwiger, P1
Schuster, H1
Terashita, K1
Nakamura, T1
Ohshima, J1
Blumlein, S1
Etingin, OR1
Hajjar, DP1
Cardillo, C1
Guerrera, G1
Melina, D1
Ohba, T1
Tonooka, M1
Kawashima, I1
Nakayama, S1
Yasuhara, H1
Sakamoto, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A European Multicentre Double-blind Placebo-controlled Phase III Trial of Nilvadipine in Mild to Moderate Alzheimer's Disease[NCT02017340]Phase 3511 participants (Actual)Interventional2013-04-24Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

21 reviews available for nifedipine and Arteriosclerosis

ArticleYear
Effects of calcium channel blockers on atherosclerosis: new insights.
    Acta cardiologica, 2002, Volume: 57, Issue:4

    Topics: Arteriosclerosis; Calcium Channel Blockers; Diuretics; Humans; Hydrochlorothiazide; Nifedipine; Sodi

2002
Combined antihypertensive and lipid-lowering treatment.
    Current hypertension reports, 2004, Volume: 6, Issue:4

    Topics: Anticholesteremic Agents; Antihypertensive Agents; Arteriosclerosis; Cardiovascular Diseases; Comorb

2004
[Treatment of hypertensive patients with impaired glucose tolerance (IGT)].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 2

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive

2005
Atheroprotective properties of nifedipine.
    International journal of tissue reactions, 2005, Volume: 27, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Arteriosclerosis; Calcium Channel Blockers; Cells, Cultured; Endot

2005
[Can nifedipine prevent aging of blood vessels?].
    Drugs, 2006, Volume: 66 Spec No 1

    Topics: Animals; Arteriosclerosis; Blood Vessels; Cellular Senescence; Muscle, Smooth, Vascular; Nifedipine

2006
Understanding the calcium channel blockers.
    Heart & lung : the journal of critical care, 1984, Volume: 13, Issue:5

    Topics: Action Potentials; Angina Pectoris; Animals; Arrhythmias, Cardiac; Arteriosclerosis; Calcium; Calciu

1984
Effects of antianginal agents on the coronary circulation.
    American heart journal, 1981, Volume: 101, Issue:4

    Topics: Angina Pectoris; Animals; Arteriosclerosis; Calcium; Collateral Circulation; Coronary Circulation; C

1981
Impact of nifedipine on vascular smooth muscle cell differentiation. Implications for atherogenesis.
    Drugs, 1994, Volume: 48 Suppl 1

    Topics: Animals; Aorta; Arteriosclerosis; Cell Differentiation; Humans; Hypercholesterolemia; Immunohistoche

1994
Hypertension treatment and prevention of new atherosclerotic plaque formation.
    Drugs, 1994, Volume: 48 Suppl 1

    Topics: Animals; Arteriosclerosis; Calcium Channel Blockers; Coronary Angiography; Coronary Vessels; Endothe

1994
Endothelial function. General considerations.
    Drugs, 1997, Volume: 53 Suppl 1

    Topics: Animals; Arteriosclerosis; Calcium Channel Blockers; Capillary Permeability; Diabetes Mellitus; Endo

1997
Pulvis de sclerotium and the mummified finger.
    Cardiovascular research, 1997, Volume: 33, Issue:1

    Topics: Algorithms; Arteriosclerosis; Calcium Channel Blockers; Ergotism; Humans; Nifedipine; Raynaud Diseas

1997
Diversity of calcium antagonists.
    Clinical therapeutics, 1997, Volume: 19 Suppl A

    Topics: Angina Pectoris; Arteriosclerosis; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Humans; Hype

1997
Anti-atherosclerotic properties of nifedipine. Benefit of early intervention to prevent cardiovascular complications.
    Cardiology, 1997, Volume: 88 Suppl 3

    Topics: Acute Disease; Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Coronary Angiography; C

1997
Intramural hematoma of the thoracic aorta in octogenarians: is non operation justified?
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1999, Volume: 16, Issue:4

    Topics: Aged; Aged, 80 and over; Analgesics; Aorta, Thoracic; Aortic Diseases; Aortography; Arteriosclerosis

1999
Long-term protection in at-risk hypertensive patients--a role for nifedipine GITS?
    Blood pressure, 2002, Volume: 11, Issue:2

    Topics: Amiloride; Arteriosclerosis; Calcium Channel Blockers; Cardiovascular Diseases; Diuretics; Drug Comb

2002
Can the coronary atherosclerotic process be influenced by calcium antagonists?
    Drugs, 1992, Volume: 44 Suppl 1

    Topics: Animals; Arteriosclerosis; Cells, Cultured; Heart; Humans; Nifedipine; Prospective Studies; Retrospe

1992
Influence of nifedipine on experimental arteriosclerosis.
    Cardiovascular drugs and therapy, 1990, Volume: 4 Suppl 5

    Topics: Animals; Arteriosclerosis; Hypertension; Nifedipine; Rabbits; Rats

1990
Advances in calcium blocker therapy.
    American journal of surgery, 1986, Volume: 151, Issue:4

    Topics: Arrhythmias, Cardiac; Arteriosclerosis; Asthma; Blood Platelet Disorders; Calcium; Calcium Channel B

1986
On a possible role for calcium antagonists in atherosclerosis. A personal view.
    European heart journal, 1986, Volume: 7, Issue:7

    Topics: Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Dis

1986
Modification of experimental atherosclerosis by calcium-channel blockers.
    The American journal of cardiology, 1985, Jan-25, Volume: 55, Issue:3

    Topics: Animals; Aorta; Arteriosclerosis; Calcium; Calcium Channel Blockers; Child; Diet, Atherogenic; Dilti

1985
Atherosclerosis, calcium, and calcium antagonists.
    Circulation, 1985, Volume: 72, Issue:3

    Topics: Animals; Aorta; Arteries; Arteriosclerosis; Calcinosis; Calcium; Calcium Channel Blockers; Cell Surv

1985

Trials

5 trials available for nifedipine and Arteriosclerosis

ArticleYear
The relationship between the degradation of prostacyclin in blood and antiplatelet drug effects in patients with atherosclerosis.
    Journal of clinical pharmacology, 1993, Volume: 33, Issue:11

    Topics: Arteriosclerosis; Dipyridamole; Double-Blind Method; Epoprostenol; Humans; Kinetics; Middle Aged; Ni

1993
Effects of aspirin, dipyridamole, nifedipine and cavinton which act on platelet aggregation induced by different aggregating agents alone and in combination.
    European journal of clinical pharmacology, 1992, Volume: 42, Issue:3

    Topics: Adenosine Diphosphate; Arteriosclerosis; Aspirin; Collagen; Dipyridamole; Double-Blind Method; Epine

1992
Effect of nifedipine administration on pulse wave velocity (PWV) of chronic hemodialysis patients--2-year trial.
    Cardiovascular drugs and therapy, 1990, Volume: 4 Suppl 5

    Topics: Adult; Arteriosclerosis; Heart; Humans; Hypertension; Middle Aged; Nifedipine; Pulse; Renal Dialysis

1990
International nifedipine trial on antiatherosclerotic therapy (INTACT).
    Cardiovascular drugs and therapy, 1987, Volume: 1, Issue:1

    Topics: Adult; Arteriosclerosis; Double-Blind Method; Humans; Middle Aged; Nifedipine

1987
On a possible role for calcium antagonists in atherosclerosis. A personal view.
    European heart journal, 1986, Volume: 7, Issue:7

    Topics: Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Dis

1986

Other Studies

61 other studies available for nifedipine and Arteriosclerosis

ArticleYear
Accelerated atherosclerosis.
    Journal of the Indian Medical Association, 2002, Volume: 100, Issue:8

    Topics: Arteriosclerosis; Calcium Channel Blockers; Coronary Artery Bypass; Coronary Disease; Endothelium, V

2002
Planimetric and histological study of the aortae in atherosclerotic chickens treated with nifedipine, verapamil and diltiazem.
    Histology and histopathology, 2003, Volume: 18, Issue:4

    Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Calcium Channel Blockers; Chickens; Ch

2003
Nilvadipine inhibits nuclear factor-kappaB-dependent transcription in hepatic cells.
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 350, Issue:1-2

    Topics: Arteriosclerosis; Base Sequence; Electrophoresis; Fibrinogen; Gene Expression; Hepatocytes; Humans;

2004
Arterial spasm during renal angioplasty.
    Radiology, 1983, Volume: 149, Issue:1

    Topics: Adolescent; Adult; Aged; Angioplasty, Balloon; Arterial Occlusive Diseases; Arteriosclerosis; Child;

1983
Verapamil suppresses atherosclerosis in cholesterol-fed rabbits.
    Journal of the American College of Cardiology, 1983, Volume: 1, Issue:6

    Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Aorta; Arteriosclerosis; Cholesterol, Diet

1983
[Strategy of the treatment of vasospastic angina pectoris].
    Archives des maladies du coeur et des vaisseaux, 1983, Volume: 76 Spec No

    Topics: Adult; Amiodarone; Angina Pectoris, Variant; Arteriosclerosis; Coronary Artery Bypass; Coronary Vaso

1983
Ineffectiveness of Ca2+-antagonists nicardipine and diltiazem on experimental atherosclerosis in cholesterol-fed rabbits.
    Angiology, 1984, Volume: 35, Issue:10

    Topics: Animals; Aorta; Arteriosclerosis; Benzazepines; Calcium; Cholesterol; Cholesterol, Dietary; Choleste

1984
Does nifedipine suppress atherogenesis in WHHL rabbits?
    Atherosclerosis, 1984, Volume: 53, Issue:1

    Topics: Animals; Aorta; Arteriosclerosis; Cholesterol; Lipoproteins; Nifedipine; Rabbits; Triglycerides

1984
The acute effects of nifedipine on calf and forefoot blood flow in patients with peripheral arterial insufficiency.
    Angiology, 1983, Volume: 34, Issue:1

    Topics: Arterial Occlusive Diseases; Arteriosclerosis; Blood Pressure; Foot; Humans; Leg; Nifedipine; Pyridi

1983
Suppression of atherogenesis in cholesterol-fed rabbit treated with nifedipine.
    The Journal of clinical investigation, 1981, Volume: 68, Issue:5

    Topics: Animals; Arteriosclerosis; Blood Pressure; Blood Proteins; Calcium; Cholesterol; Cholesterol, Dietar

1981
[Evaluation of coronary arterial morphology using intravascular ultrasound].
    Japanese circulation journal, 1994, Volume: 58 Suppl 4

    Topics: Aged; Arteriosclerosis; Coronary Vessels; Elasticity; Humans; Nifedipine; Ultrasonography, Intervent

1994
Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations.
    Journal of cardiovascular pharmacology, 1994, Volume: 24 Suppl 2

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cells,

1994
Effects of nifedipine on mechanical properties of the normal and atherosclerotic descending aorta assessed by transesophageal echocardiography.
    The American journal of cardiology, 1994, Nov-15, Volume: 74, Issue:10

    Topics: Adult; Aged; Aorta, Thoracic; Arteriosclerosis; Echocardiography, Transesophageal; Female; Humans; M

1994
Comparable beneficial effects of defibrotide and nifedipine in calcium induced atherosclerosis.
    Life sciences, 1994, Volume: 54, Issue:12

    Topics: Animals; Arteriosclerosis; Body Weight; Calcium; Calcium Channel Blockers; Male; Nifedipine; Polydeo

1994
[An experimental study on the mechanism of antiatherosclerotic effect of nifedipine].
    Zhonghua xin xue guan bing za zhi, 1993, Volume: 21, Issue:3

    Topics: Animals; Aorta; Arteriosclerosis; Calcium; Cholesterol, Dietary; Cytoplasm; Male; Malondialdehyde; M

1993
The effect of nifedipine on lipid and monocyte infiltration of the subendothelial space.
    Journal of vascular surgery, 1993, Volume: 17, Issue:5

    Topics: Animals; Arteriosclerosis; Calcium; Cattle; Cell Membrane Permeability; Cells, Cultured; Endothelium

1993
Differential effect of two calcium channel blockers--nifedipine and diltiazem--on atherogenesis in hypercholesterolemic hamster.
    Journal of submicroscopic cytology and pathology, 1996, Volume: 28, Issue:2

    Topics: Animals; Aorta, Thoracic; Aortic Valve; Arteriosclerosis; Calcium Channel Blockers; Coronary Vessels

1996
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat.
    Pharmacology, 1997, Volume: 54, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Arteriosclerosis; Calcium Channel Blockers; C

1997
Arachidonic acid pretreatment enhances smooth muscle cell migration via increased Ca2+ influx.
    Prostaglandins, leukotrienes, and essential fatty acids, 1998, Volume: 58, Issue:1

    Topics: Animals; Arachidonic Acid; Arteriosclerosis; Becaplermin; Calcium; Calcium Channel Blockers; Cattle;

1998
Nifedipine-induced transient cerebral ischemia in a child with Cockayne syndrome.
    Anaesthesia, 1997, Volume: 52, Issue:12

    Topics: Arteriosclerosis; Brain Ischemia; Calcium Channel Blockers; Child; Cockayne Syndrome; Female; Humans

1997
Platelet hyperactivity in hypertensive older patients is controlled by lowering blood pressure.
    Journal of the American Geriatrics Society, 1999, Volume: 47, Issue:8

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteriosclerosis; Blood Pre

1999
Nilvadipine protects low-density lipoprotein cholesterol from in vivo oxidation in hypertensive patients with risk factors for atherosclerosis.
    European journal of clinical pharmacology, 2000, Volume: 56, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Arteriosclerosis; Case-Control Studies; Cho

2000
Peripheral vascular dynamics studied by calcium ion inhibition.
    Angiology, 1978, Volume: 29, Issue:7

    Topics: Adult; Aged; Arteriosclerosis; Calcium; Diabetic Angiopathies; Humans; Middle Aged; Muscle, Smooth;

1978
[Comparison of the effect of nifedipine and verapamil on lipid metabolism in experimental atherosclerosis in rabbits].
    Bratislavske lekarske listy, 1992, Volume: 93, Issue:11

    Topics: Animals; Arteriosclerosis; Fatty Acids; Lipids; Male; Nifedipine; Rabbits; Verapamil

1992
Calcium, calcium antagonism, atherosclerosis, and ischemia.
    Journal of cardiovascular pharmacology, 1992, Volume: 19 Suppl 2

    Topics: Animals; Arteriosclerosis; Calcium; Coronary Disease; Cytosol; Humans; Hypercholesterolemia; Hyperte

1992
[Inhibition of experimental atherosclerosis in swine by nifedipine].
    Zhonghua xin xue guan bing za zhi, 1992, Volume: 20, Issue:1

    Topics: Animals; Aorta; Arteriosclerosis; Male; Nifedipine; Swine; Swine, Miniature

1992
[The effect of verapamil and nifedipine on the development of experimental atherosclerosis in rabbits].
    Bratislavske lekarske listy, 1992, Volume: 93, Issue:1

    Topics: Animals; Aorta; Arteriosclerosis; Lipids; Male; Nifedipine; Rabbits; Verapamil

1992
Use of cultured atherosclerotic cells for investigation of antiatherosclerotic effects of anipamil and other calcium antagonists.
    Journal of human hypertension, 1991, Volume: 5, Issue:5

    Topics: Aorta; Arteriosclerosis; Calcium Channel Blockers; Cell Division; Cells, Cultured; Cholesterol; Endo

1991
Vascular injury: mechanisms and manifestations.
    The American journal of medicine, 1991, Apr-25, Volume: 90, Issue:4B

    Topics: Amlodipine; Animals; Aorta, Thoracic; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cardiomeg

1991
Vascular and myocardial effects of amlodipine: an overview.
    Postgraduate medical journal, 1991, Volume: 67 Suppl 5

    Topics: Amlodipine; Animals; Arteriosclerosis; Binding Sites; Calcium Channel Blockers; Cardiomegaly; Cerebr

1991
[The effects of nifedipine, diltiazem, and Paeonia lactiflora Pall. on atherogenesis in rabbits].
    Zhonghua xin xue guan bing za zhi, 1991, Volume: 19, Issue:2

    Topics: Animals; Aorta; Arteriosclerosis; Diltiazem; Drugs, Chinese Herbal; Male; Nifedipine; Rabbits

1991
Cerebral-artery spasm in vitro.
    Lancet (London, England), 1990, Jan-13, Volume: 335, Issue:8681

    Topics: Arteriosclerosis; Cerebral Arteries; Dinoprost; Humans; In Vitro Techniques; Muscle Contraction; Nif

1990
Quantitative analysis of antiatherosclerotic effect of nifedipine in cholesterol-fed rabbits.
    Cardiovascular drugs and therapy, 1990, Volume: 4 Suppl 5

    Topics: Animals; Aorta; Arteriosclerosis; Body Weight; Cholesterol; Cholesterol, Dietary; Dose-Response Rela

1990
Nifedipine and experimental cardioprotection.
    Cardiovascular drugs and therapy, 1990, Volume: 4 Suppl 5

    Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Binding Sites; Calcium; Cholesterol; Coronary Disease; E

1990
Protecting the vasculature: an eye toward the future.
    The American journal of cardiology, 1990, Nov-20, Volume: 66, Issue:18

    Topics: Amlodipine; Animals; Arteries; Arteriosclerosis; Blood Pressure; Calcium Channel Blockers; Cerebrova

1990
The role of calcium and magnesium in the development of atherosclerosis. Experimental and clinical evidence.
    Annals of the New York Academy of Sciences, 1990, Volume: 598

    Topics: Animals; Arteriosclerosis; Calcium; Cells, Cultured; DNA; Epidermal Growth Factor; Female; Guinea Pi

1990
In vitro models of anti-atherosclerotic effects of cardiovascular drugs.
    The American journal of cardiology, 1990, Dec-18, Volume: 66, Issue:21

    Topics: Arteriosclerosis; Cell Division; Cells, Cultured; Humans; Models, Biological; Muscle, Smooth, Vascul

1990
Nifedipine reduces atherogenesis in cholesterol-fed heterozygous WHHL rabbits.
    Atherosclerosis, 1990, Volume: 84, Issue:2-3

    Topics: Animals; Aorta; Arteriosclerosis; Calcium; Cholesterol; Cholesterol Esters; Cholesterol, Dietary; Co

1990
Calcium blockers: antiatherogenic action by influencing the prostaglandin-system.
    Progress in clinical and biological research, 1989, Volume: 301

    Topics: Adult; Animals; Arteriosclerosis; Calcium Channel Blockers; Diltiazem; Epoprostenol; Female; Humans;

1989
Amlodipine, a new 1,4-dihydropyridine calcium antagonist with a particularly strong antihypertensive profile.
    The American journal of cardiology, 1989, Nov-07, Volume: 64, Issue:17

    Topics: Amlodipine; Animals; Antihypertensive Agents; Arteriosclerosis; Calcium; Calcium Channel Blockers; D

1989
Suppression of atherogenesis in cholesterol-fed rabbits treated with nilvadipine, a new vasoselective calcium entry blocker.
    Atherosclerosis, 1989, Volume: 79, Issue:2-3

    Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Blood Pressure; Calcium; Calcium Channel Blockers; Chole

1989
Mechanism of antiatherogenic action of calcium antagonists.
    Atherosclerosis, 1989, Volume: 80, Issue:1

    Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Catheterization; DNA Replication; Male

1989
[Pharmacologic inhibition of experimental atherosclerosis].
    Zeitschrift fur Kardiologie, 1989, Volume: 78 Suppl 6

    Topics: Animals; Arteriosclerosis; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug;

1989
Suppression of atherogenesis by nifedipine in the cholesterol-fed rhesus monkey.
    Applied pathology, 1989, Volume: 7, Issue:1

    Topics: Animals; Arteries; Arteriosclerosis; Cholesterol, Dietary; Macaca mulatta; Male; Nifedipine

1989
Atheromatous embolism: varied clinical presentation and prognosis.
    Southern medical journal, 1989, Volume: 82, Issue:7

    Topics: Aged; Arteriosclerosis; Embolism; Female; Humans; Leg; Male; Middle Aged; Nifedipine; Prognosis; Sym

1989
Suppression of rat carotid lesion development by the calcium channel blocker PN 200-110.
    The American journal of pathology, 1986, Volume: 124, Issue:1

    Topics: Angioplasty, Balloon; Animals; Arteriosclerosis; Blood Platelets; Blood Pressure; Carotid Arteries;

1986
The calcium antagonist nifedipine inhibits arterial smooth muscle cell proliferation.
    Atherosclerosis, 1985, Volume: 58, Issue:1-3

    Topics: Actins; Animals; Arteries; Arteriosclerosis; Cell Division; Cyclic AMP; DNA; In Vitro Techniques; Ma

1985
Effects of calcium antagonists on low density lipoprotein metabolism in human arterial smooth muscle cells.
    The Tohoku journal of experimental medicine, 1988, Volume: 154, Issue:4

    Topics: Arteriosclerosis; Calcium Channel Blockers; Cells, Cultured; Humans; Lipoproteins, LDL; Muscle, Smoo

1988
Protective action of a calcium antagonist, nilvadipine, against aortic calcium deposition--a pathogenic factor in atherosclerosis.
    Atherosclerosis, 1988, Volume: 73, Issue:2-3

    Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Calcium; Calcium Channel Blockers; Dose-Response Relatio

1988
Hypertension and atherosclerosis in cholesterol-fed rabbits. II. One-kidney, one clip Goldblatt hypertension treated with nifedipine.
    Atherosclerosis, 1987, Volume: 66, Issue:1-2

    Topics: Animals; Aorta; Arteriosclerosis; Blood Pressure; Cholesterol; Diet; Hematocrit; Hypertension, Renov

1987
The beneficial influence of nifedipine on the regression of the cholesterol-induced atherosclerosis in rabbits.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1987, Volume: 187, Issue:5

    Topics: Animals; Aorta; Apolipoproteins B; Arteriosclerosis; Cholesterol; Female; Hypercholesterolemia; Nife

1987
Failure of nifedipine to reduce atherogenesis in cholesterol-fed rabbits.
    Artery, 1986, Volume: 13, Issue:5

    Topics: Animals; Aorta; Arteriosclerosis; Blood Pressure; Cholesterol; Cholesterol, Dietary; Male; Nifedipin

1986
Increased platelet calcium in thrombosis and related disorders and its correction by nifedipine.
    Thrombosis research, 1987, Jan-15, Volume: 45, Issue:2

    Topics: Arteriosclerosis; Blood Platelets; Calcium; Homeostasis; Humans; Nifedipine; Thrombosis; Vascular Di

1987
Nifedipine-suppressed atherosclerosis in cholesterol-fed rabbits but not in Watanabe heritable hyperlipidemic rabbits.
    Atherosclerosis, 1987, Volume: 64, Issue:1

    Topics: Animals; Arteriosclerosis; Cholesterol, Dietary; Hyperlipidemias; Male; Nifedipine; Rabbits

1987
Antiatherogenic activity of FR34235 (Nilvadipine), a new potent calcium antagonist. Effect on cuff-induced intimal thickening of rabbit carotid artery.
    Atherosclerosis, 1987, Volume: 64, Issue:2-3

    Topics: Animals; Arteriosclerosis; Calcium Channel Blockers; Carotid Arteries; Carotid Artery Diseases; Male

1987
Nifedipine suppressed atherosclerosis in cholesterol-fed rabbits but not in Watanabe heritable hyperlipidemic rabbits.
    Artery, 1987, Volume: 14, Issue:5

    Topics: Administration, Oral; Animals; Aorta; Arteriosclerosis; Cholesterol, Dietary; Female; Hyperlipidemia

1987
[Is there a hyporeactivity of the vascular wall to atherogenic risk factors?].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1986, Jul-15, Volume: 41, Issue:14

    Topics: Aged; Aged, 80 and over; Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Endothelium;

1986
Ca and atherosclerosis.
    Journal of nutritional science and vitaminology, 1985, Volume: 31 Suppl

    Topics: Aged; Aging; Animals; Aorta; Arteries; Arteriosclerosis; Bone Diseases; Calcinosis; Calcium; Calcium

1985
Nifedipine increases cholesteryl ester hydrolytic activity in lipid-laden rabbit arterial smooth muscle cells. A possible mechanism for its antiatherogenic effect.
    The Journal of clinical investigation, 1985, Volume: 75, Issue:5

    Topics: Animals; Arteriosclerosis; beta-Galactosidase; Cattle; Cells, Cultured; Cholesterol; Cholesterol Est

1985
[Effect of nifedipine on peripheral blood flow in patients with atherosclerotic arterial disease of the lower limbs. A controlled study].
    La Clinica terapeutica, 1985, Mar-15, Volume: 112, Issue:5

    Topics: Arteriosclerosis; Humans; Leg; Nifedipine; Regional Blood Flow

1985
[Effect of nicardipine on cholesterol-fed S.H.R].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985, Volume: 86, Issue:2

    Topics: Animals; Aorta; Arteriosclerosis; Body Weight; Heart Rate; Hyperlipidemias; Hypertension; Lipids; Li

1985