nifedipine has been researched along with Amyotrophic Lateral Sclerosis in 7 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis (ALS), we compared the sensitivity of motor neurons and that of dorsal horn neurons to kainic acid (KA)." | 3.70 | Ca(2+)-permeable AMPA receptors and selective vulnerability of motor neurons. ( Klaassen, H; Robberecht, W; Van Den Bosch, L; Van Houtte, E; Vandenberghe, W, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikenaka, K | 1 |
| Tsukada, Y | 1 |
| Giles, AC | 1 |
| Arai, T | 1 |
| Nakadera, Y | 1 |
| Nakano, S | 1 |
| Kawai, K | 1 |
| Mochizuki, H | 1 |
| Katsuno, M | 1 |
| Sobue, G | 1 |
| Mori, I | 1 |
| Pambo-Pambo, A | 1 |
| Durand, J | 1 |
| Gueritaud, JP | 1 |
| Spalloni, A | 1 |
| Pascucci, T | 1 |
| Albo, F | 1 |
| Ferrari, F | 1 |
| Puglisi-Allegra, S | 1 |
| Zona, C | 1 |
| Bernardi, G | 1 |
| Longone, P | 1 |
| Sathasivam, S | 1 |
| Grierson, AJ | 1 |
| Shaw, PJ | 1 |
| Magnelli, V | 1 |
| Sawada, T | 1 |
| Delbono, O | 2 |
| Smith, RG | 1 |
| Appel, SH | 2 |
| Stefani, E | 2 |
| Van Den Bosch, L | 1 |
| Vandenberghe, W | 1 |
| Klaassen, H | 1 |
| Van Houtte, E | 1 |
| Robberecht, W | 1 |
| García, J | 1 |
7 other studies available for nifedipine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
A behavior-based drug screening system using a Caenorhabditis elegans model of motor neuron disease.
Topics: Amyotrophic Lateral Sclerosis; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Dis | 2019 |
Early excitability changes in lumbar motoneurons of transgenic SOD1G85R and SOD1G(93A-Low) mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Arginine; Biophysical Phenomena; Biophysics; Calcium Channel | 2009 |
Altered vulnerability to kainate excitotoxicity of transgenic-Cu/Zn SOD1 neurones.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Asparagine; Calcium Channel Blockers; | 2004 |
Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Apoptosis; Blotting, Western; Calcium | 2005 |
The action of amyotrophic lateral sclerosis immunoglobulins on mammalian single skeletal muscle Ca2+ channels.
Topics: Amyotrophic Lateral Sclerosis; Calcium Channels; Dihydropyridines; Humans; Immunoglobulin G; In Vitr | 1993 |
Ca(2+)-permeable AMPA receptors and selective vulnerability of motor neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amyotrophic Lateral Sclerosis; Animals; Benzodiazepines; Calci | 2000 |
IgG from amyotrophic lateral sclerosis affects tubular calcium channels of skeletal muscle.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Calcium Channels; Female; Humans; Immunoglobulin G; Male | 1991 |