nifedipine has been researched along with Aging in 112 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The Modern Approach to the Treatment of Hypertension (MATH) trial was conducted to determine the therapeutic safety and efficacy of the once-a-day nifedipine gastrointestinal therapeutic system (GITS) formulation in a large and diverse cohort of patients with mild-to-moderate hypertension." | 9.06 | Antihypertensive effectiveness of nifedipine gastrointestinal therapeutic system in the elderly. The Modern Approach to the Treatment of Hypertension (MATH) Study Group. ( Bravo, EL; Friedman, CP; Krakoff, LR; Tuck, ML, 1990) |
| " Nifedipine treatment in both young and adult hypertensive rats prevented the V3 rise due to hypertension and to the aging process." | 7.70 | Age-related difference in cardiac adaptation to chronic hypertension in rats, with and without nifedipine treatment. ( Malhotra, A; Nakouzi, A; Pathak, D; Raizada, V; Skipper, B, 1999) |
| "The effects of nifedipine and enalapril on age-associated renal interstitial fibrosis were investigated in 60 CF1 female mice." | 7.69 | Renal interstitial sclerosis in aging: effects of enalapril and nifedipine. ( de Cavanagh, EM; Ercole, L; Ferder, LF; Gomez, RA; Inserra, F; Romano, LA, 1996) |
| " Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits." | 7.68 | Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990) |
| " Allosteric modulation of [3H]-NTP binding by the phenylalkylamine, verapamil and the benzothiazepine, diltiazem were preserved in aging heart." | 7.68 | Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters. ( Howlett, SE; Nicholl, PA, 1992) |
| " This study evaluated the influence of aging, superimposed chronic hypertension on aging, and treatment with nifedipine on cardiac myosin isozyme proportions." | 7.68 | Alterations in cardiac myosin isozymes associated with aging and chronic hypertension: their modulation with nifedipine. ( Blomquist, TM; Minser, R; Pathak, D; Raizada, V; Woodfin, B, 1993) |
| "Pharmacodynamics and disposition of amlodipine, a dihydropyridine calcium antagonist, were compared between elderly and young patients with hypertension." | 7.68 | Effects of amlodipine, a long-acting dihydropyridine calcium antagonist in aging hypertension: pharmacodynamics in relation to disposition. ( Abernethy, DR; Gutkowska, J; Winterbottom, LM, 1990) |
| "The drug is equally effective in treating hypertension in elderly and younger patients and does not appear to adversely affect glucose or lipid metabolism." | 6.39 | Nilvadipine. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic use in hypertension and potential in cerebrovascular disease and angina. ( Brogden, RN; McTavish, D, 1995) |
| " In both age groups, chronic nifedipine administration reduced neurogenic contractions of isolated superior mesenteric artery, but did not significantly affect the dose-response curve to exogenous noradrenaline in 8-week-old rats." | 5.35 | Effect of chronic nifedipine treatment on blood pressure and adrenergic responses of isolated mesenteric artery in young rats with developing spontaneous hypertension. ( Török, J; Zemančíková, A, 2009) |
| "Amlodipine is a long-acting dihydropyridine-based calcium antagonist developed for use on a once-a-day basis." | 5.27 | The effect of amlodipine on hypertension-induced cardiac hypertrophy and reperfusion-induced calcium overload. ( Nayler, WG, 1988) |
| "The Modern Approach to the Treatment of Hypertension (MATH) trial was conducted to determine the therapeutic safety and efficacy of the once-a-day nifedipine gastrointestinal therapeutic system (GITS) formulation in a large and diverse cohort of patients with mild-to-moderate hypertension." | 5.06 | Antihypertensive effectiveness of nifedipine gastrointestinal therapeutic system in the elderly. The Modern Approach to the Treatment of Hypertension (MATH) Study Group. ( Bravo, EL; Friedman, CP; Krakoff, LR; Tuck, ML, 1990) |
| " Nifedipine treatment in both young and adult hypertensive rats prevented the V3 rise due to hypertension and to the aging process." | 3.70 | Age-related difference in cardiac adaptation to chronic hypertension in rats, with and without nifedipine treatment. ( Malhotra, A; Nakouzi, A; Pathak, D; Raizada, V; Skipper, B, 1999) |
| "The influence of aging and of treatment with the dihydropyridine Ca2+ antagonist darodipine (PY 108-068) on the age-related microanatomical changes of rat brain were studied in male Wistar rats treated from the 18th to the 24th month of age with an oral dose of 5 mg/kg/day of darodipine." | 3.69 | Age-related changes in brain microanatomy: sensitivity to treatment with the dihydropyridine calcium channel blocker darodipine (PY 108-068). ( Amenta, F; Cavallotti, D; Del Valle, M; Mancini, M; Naves, FJ; Vega, JA; Zeng, YC, 1995) |
| " In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride (KCl) and nifedipine of aortae from SHRSP and control (Wistar-Kyoto) WKY rats of different age groups (young: 3-5 weeks, and adult: 13-16 weeks)." | 3.69 | The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age. ( Iwanov, V; Jiang, GC; Moulds, RF, 1995) |
| "To determine whether chronic treatment with enalapril initiated early in life prevents glomerular injury secondary to normal aging, CF1 mice received enalapril (20 mg/L, n = 10) or nifedipine (40 mg/L, n = 10) in their drinking water from the time of weaning to 12 months of life." | 3.69 | Intraglomerular expression of alpha-smooth muscle actin in aging mice. ( Ercole, L; Ferder, L; Gomez, RA; Inserra, F; Romano, LA, 1994) |
| "The effects of nifedipine and enalapril on age-associated renal interstitial fibrosis were investigated in 60 CF1 female mice." | 3.69 | Renal interstitial sclerosis in aging: effects of enalapril and nifedipine. ( de Cavanagh, EM; Ercole, L; Ferder, LF; Gomez, RA; Inserra, F; Romano, LA, 1996) |
| " Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits." | 3.68 | Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990) |
| " Allosteric modulation of [3H]-NTP binding by the phenylalkylamine, verapamil and the benzothiazepine, diltiazem were preserved in aging heart." | 3.68 | Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters. ( Howlett, SE; Nicholl, PA, 1992) |
| " This study evaluated the influence of aging, superimposed chronic hypertension on aging, and treatment with nifedipine on cardiac myosin isozyme proportions." | 3.68 | Alterations in cardiac myosin isozymes associated with aging and chronic hypertension: their modulation with nifedipine. ( Blomquist, TM; Minser, R; Pathak, D; Raizada, V; Woodfin, B, 1993) |
| "Pharmacodynamics and disposition of amlodipine, a dihydropyridine calcium antagonist, were compared between elderly and young patients with hypertension." | 3.68 | Effects of amlodipine, a long-acting dihydropyridine calcium antagonist in aging hypertension: pharmacodynamics in relation to disposition. ( Abernethy, DR; Gutkowska, J; Winterbottom, LM, 1990) |
| "Terazosin treatment did not show consistent decrease of casual BP, but was associated with a transient decrease of systolic BP and an increase of pulse rate after standing, and enhanced postprandial decrease in BP." | 2.69 | Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke. ( Abe, I; Fujishima, M; Hasuo, Y; Nishino, Y; Onaka, U; Setoguchi, M, 1998) |
| " These findings imply that verapamil dosage should be reduced in patients with impaired renal function and elderly patients." | 2.65 | Pharmacokinetics of calcium blockers in patients with renal insufficiency and in geriatric patients. ( Larsen, A; Midtbø, K; Saevareid, L; Storstein, L, 1984) |
| "The drug is equally effective in treating hypertension in elderly and younger patients and does not appear to adversely affect glucose or lipid metabolism." | 2.39 | Nilvadipine. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic use in hypertension and potential in cerebrovascular disease and angina. ( Brogden, RN; McTavish, D, 1995) |
| "Amlodipine, a dihydropyridine calcium antagonist, was synthesized in an attempt to develop a compound with a pharmacokinetic profile characteristic of this class, which would also have an increased oral bioavailability and extended clearance time." | 2.38 | The pharmacokinetic profile of amlodipine. ( Abernethy, DR, 1989) |
| " Nevertheless, this procedure may provide useful information for optimizing the dosage regimen of each patient as the pathological condition and drug therapy may be quite complex." | 2.37 | Pharmacokinetics of diltiazem and other calcium entry blockers. ( Hermann, P; Morselli, PL, 1985) |
| " The bioavailability of diltiazem and nifedipine has not been well studied, and no investigations of the absolute bioavailability of these compounds have been reported." | 2.36 | Calcium antagonists. Pharmacokinetic properties. ( Kates, RE, 1983) |
| " In both age groups, chronic nifedipine administration reduced neurogenic contractions of isolated superior mesenteric artery, but did not significantly affect the dose-response curve to exogenous noradrenaline in 8-week-old rats." | 1.35 | Effect of chronic nifedipine treatment on blood pressure and adrenergic responses of isolated mesenteric artery in young rats with developing spontaneous hypertension. ( Török, J; Zemančíková, A, 2009) |
| " In the beta cell of aged rats, the following abnormalities were found: (a) right shift of the dose-response curve (depressed sensitivity) of glucose-induced insulin release, (b) no increase of the maximum response to glucose in the face of increased insulin content of the islets (reduced responsiveness), (c) no response to forskolin and normal response to the phorbol ester and glyburide, and (d) increased sensitivity to nifedipine." | 1.29 | Insulin secretion by the pancreatic beta cell of aged rats. ( Aizawa, T; Hashizume, K; Ishihara, F; Komatsu, M; Nishii, N; Sato, Y; Suzuki, N; Yamada, T, 1994) |
| "Treatment with darodipine increased the number and the average length of alkaline phosphatase-reactive capillaries and reduced the intercapillary distance and the diameter of cerebral capillaries in old rats." | 1.29 | Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine (PY 108-068) on the cerebral capillary network in aged rats. ( Amenta, F; Ferrante, F; Mancini, M; Sabbatini, M; Vega, JA; Zaccheo, D, 1995) |
| "Larger doses of BAY K 8644 produced arrhythmias only in 12 months old rats, which was not totally abolished by nitroglycerine pretreatment." | 1.28 | Enhancement in myocardial inotropic response to BAY K 8644 with advancing age. ( Khatter, JC; Navaratnam, S, 1992) |
| "Nifedipine was added at 10 weeks of age." | 1.28 | Dietary sodium and the antihypertensive effect of nifedipine in spontaneously hypertensive rats. ( Leenen, FH; Yuan, B, 1992) |
| "1." | 1.28 | Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. ( Christ, GJ; Maayani, S; Melman, A; Valcic, M, 1990) |
| "Amlodipine is a long-acting dihydropyridine-based calcium antagonist developed for use on a once-a-day basis." | 1.27 | The effect of amlodipine on hypertension-induced cardiac hypertrophy and reperfusion-induced calcium overload. ( Nayler, WG, 1988) |
| " amlodipine, clearance tended to be decreased in elderly as compared with young patients with resulting prolongation in elimination half-life (64 +/- 20 vs." | 1.27 | Amlodipine in elderly hypertensive patients: pharmacokinetics and pharmacodynamics. ( Abernethy, DR; Gutkowska, J; Lambert, MD, 1988) |
| " Healthy young and elderly volunteers received 20 mg nifedipine (slow release) orally for 2 weeks with concomitant dosing of atenolol 50 mg orally during the second week." | 1.27 | The effect of ageing on the disposition of nifedipine and atenolol. ( Adam, HK; Castleden, CM; Fitzsimons, TJ; Scott, M; Smith, RP, 1988) |
| " The trend towards an increased bioavailability in elderly subjects (36%) was supported by a significantly lower nitropyridine metabolite/nifedipine ratio in the elderly." | 1.27 | Age-related changes in the pharmacokinetics and pharmacodynamics of nifedipine. ( George, CF; Renwick, AG; Robertson, DR; Waller, DG, 1988) |
| " All patients received 20 mg nifedipine, in slow-release tablet form, twice daily; at Week 4, dosage was increased to 40 mg twice daily in 8." | 1.27 | The antihypertensive efficacy of nifedipine alone and in combination in general practice. ( Duffy, J; Macdonald, G, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (26.79) | 18.7374 |
| 1990's | 62 (55.36) | 18.2507 |
| 2000's | 13 (11.61) | 29.6817 |
| 2010's | 6 (5.36) | 24.3611 |
| 2020's | 1 (0.89) | 2.80 |
| Authors | Studies |
|---|---|
| Pignier, C | 1 |
| Potreau, D | 1 |
| West, HL | 1 |
| Corbin, KL | 1 |
| D'Angelo, CV | 1 |
| Donovan, LM | 1 |
| Jahan, I | 1 |
| Gu, G | 1 |
| Nunemaker, CS | 1 |
| Hamaguchi, S | 1 |
| Kawakami, Y | 1 |
| Honda, Y | 1 |
| Nemoto, K | 1 |
| Sano, A | 1 |
| Namekata, I | 1 |
| Tanaka, H | 1 |
| Kumar, A | 2 |
| Foster, TC | 3 |
| Kouvaros, S | 1 |
| Kotzadimitriou, D | 1 |
| Papatheodoropoulos, C | 1 |
| Zemančíková, A | 1 |
| Török, J | 1 |
| Ahmed, T | 1 |
| Sabanov, V | 1 |
| D'Hooge, R | 1 |
| Balschun, D | 1 |
| Thornton, AM | 1 |
| Zhao, X | 1 |
| Weisleder, N | 1 |
| Brotto, LS | 1 |
| Bougoin, S | 1 |
| Nosek, TM | 1 |
| Reid, M | 1 |
| Hardin, B | 1 |
| Pan, Z | 1 |
| Ma, J | 1 |
| Parness, J | 1 |
| Brotto, M | 1 |
| Bertin, R | 1 |
| Garcia-Argaéz, A | 1 |
| Martìnez-Vàzquez, M | 1 |
| Froldi, G | 2 |
| Noble, K | 1 |
| Wray, S | 1 |
| Spolidorio, LC | 1 |
| Spolidorio, DM | 1 |
| Nassar, PO | 1 |
| Nassar, CA | 1 |
| Holzhausen, M | 1 |
| Almeida, OP | 1 |
| Cogolludo, A | 1 |
| Moreno, L | 1 |
| Lodi, F | 1 |
| Tamargo, J | 1 |
| Perez-Vizcaino, F | 1 |
| Himeda, T | 1 |
| Kanbara, S | 1 |
| Oki, C | 1 |
| Kato, H | 1 |
| Araki, T | 1 |
| Hannan, JL | 1 |
| Smallegange, C | 1 |
| Hale, TM | 1 |
| Heaton, JP | 1 |
| Adams, MA | 1 |
| Jones, SA | 1 |
| Boyett, MR | 1 |
| Lancaster, MK | 1 |
| Io, K | 1 |
| Minatoguchi, S | 1 |
| Nishigaki, K | 1 |
| Ojio, S | 1 |
| Tanaka, T | 1 |
| Segawa, T | 1 |
| Matsuo, H | 1 |
| Watanabe, S | 1 |
| Hattori, A | 1 |
| Ueno, K | 1 |
| Ono, H | 1 |
| Hiei, K | 1 |
| Sato, H | 1 |
| Morita, N | 1 |
| Noda, T | 1 |
| Kato, T | 1 |
| Kawasaki, M | 1 |
| Takemura, G | 1 |
| Fujiwara, H | 1 |
| Kazda, S | 1 |
| Garthoff, B | 1 |
| Luckhaus, G | 1 |
| Boucek, RJ | 1 |
| Shelton, M | 1 |
| Artman, M | 2 |
| Mushlin, PS | 1 |
| Starnes, VA | 1 |
| Olson, RD | 1 |
| Hulthén, UL | 1 |
| Bolli, P | 1 |
| Bühler, FR | 1 |
| MacDonald, A | 1 |
| McGrath, JC | 1 |
| Kazazoglou, T | 1 |
| Schmid, A | 1 |
| Renaud, JF | 1 |
| Lazdunski, M | 1 |
| Kates, RE | 1 |
| Storstein, L | 1 |
| Larsen, A | 1 |
| Midtbø, K | 1 |
| Saevareid, L | 1 |
| Rakusan, K | 1 |
| Shimamoto, H | 1 |
| Shimamoto, Y | 1 |
| Amenta, F | 4 |
| Ferrante, F | 1 |
| Mancini, M | 3 |
| Sabbatini, M | 2 |
| Vega, JA | 4 |
| Zaccheo, D | 2 |
| Lorenzon, NM | 1 |
| Foehring, RC | 1 |
| Matsubara, H | 1 |
| Suzuki, J | 1 |
| Inada, M | 1 |
| Rossi, P | 1 |
| D'Angelo, E | 1 |
| Magistretti, J | 1 |
| Toselli, M | 1 |
| Taglietti, V | 1 |
| Brogden, RN | 1 |
| McTavish, D | 1 |
| Cavallotti, D | 1 |
| Del Valle, M | 1 |
| Naves, FJ | 2 |
| Zeng, YC | 1 |
| Wetzel, GT | 1 |
| Chen, F | 1 |
| Klitzner, TS | 1 |
| Jiang, GC | 1 |
| Iwanov, V | 1 |
| Moulds, RF | 1 |
| Del Valle, ME | 1 |
| Gurdal, H | 1 |
| Friedman, E | 1 |
| Johnson, MD | 1 |
| Rothe, T | 1 |
| Grantyn, R | 1 |
| Ragazzi, E | 2 |
| Chinellato, A | 2 |
| Pandolfo, L | 1 |
| Caparrotta, L | 1 |
| Fassina, G | 1 |
| Friedman, DJ | 1 |
| Duckles, SP | 1 |
| Aizawa, T | 1 |
| Komatsu, M | 1 |
| Sato, Y | 1 |
| Ishihara, F | 1 |
| Suzuki, N | 1 |
| Nishii, N | 1 |
| Hashizume, K | 1 |
| Yamada, T | 1 |
| Wuorela, H | 1 |
| Arvola, P | 1 |
| Kähönen, M | 1 |
| Vapaatalo, H | 1 |
| Pörsti, I | 1 |
| Strauss, O | 1 |
| Wienrich, M | 1 |
| Kocemba, J | 1 |
| Kawecka-Jaszcz, K | 1 |
| Grodzicki, T | 1 |
| Czarnecka, D | 1 |
| Gryglewska, B | 1 |
| Skalska, A | 1 |
| Raizada, V | 3 |
| Pathak, D | 3 |
| Nakouzi, A | 2 |
| Malhotra, A | 2 |
| Lorimer, AR | 1 |
| Anderson, JA | 1 |
| Laher, MS | 1 |
| Davies, J | 1 |
| Lazarus, JH | 1 |
| Taylor, SH | 1 |
| Sanghera, S | 1 |
| Romano, LA | 2 |
| Ferder, L | 1 |
| Inserra, F | 2 |
| Ercole, L | 2 |
| Gomez, RA | 2 |
| Fraeyman, N | 1 |
| van Ermen, A | 1 |
| Blomquist, TM | 1 |
| Minser, R | 1 |
| Woodfin, B | 1 |
| Paolisso, G | 1 |
| Gambardella, A | 1 |
| Balbi, V | 1 |
| Galzerano, D | 1 |
| Verza, M | 1 |
| Varricchio, M | 1 |
| D'Onofrio, F | 1 |
| de Cavanagh, EM | 1 |
| Ferder, LF | 1 |
| Acone, D | 1 |
| Cante, D | 1 |
| Cillo, F | 1 |
| Giordano, G | 1 |
| Giordano, C | 1 |
| Hernández, MC | 1 |
| Salaices, M | 1 |
| Arribas, S | 1 |
| Sánchez-Ferrer, CF | 1 |
| Marín, J | 1 |
| Sugiura, Y | 1 |
| Ko, CP | 1 |
| Italiano, G | 1 |
| Pagano, F | 1 |
| Calabrò, A | 1 |
| Eddinger, TJ | 1 |
| Ratz, PH | 1 |
| Joseph, JA | 2 |
| Strain, JG | 1 |
| Jimenez, ND | 1 |
| Fisher, D | 1 |
| Elliott, HL | 2 |
| Meredith, PA | 2 |
| Shankar, S | 1 |
| Teyler, TJ | 1 |
| Robbins, N | 1 |
| Haddock, PS | 1 |
| Coetzee, WA | 1 |
| Norris, CM | 1 |
| Halpain, S | 1 |
| Tarasenko, AN | 1 |
| Isaev, DS | 1 |
| Eremin, AV | 1 |
| Kostyuk, PG | 1 |
| Qin, ZL | 1 |
| Nishimura, H | 1 |
| Setoguchi, M | 1 |
| Onaka, U | 1 |
| Abe, I | 1 |
| Hasuo, Y | 1 |
| Nishino, Y | 1 |
| Fujishima, M | 1 |
| Conlin, PR | 1 |
| Elkins, M | 1 |
| Liss, C | 1 |
| Vrecenak, AJ | 1 |
| Barr, E | 1 |
| Edelman, JM | 1 |
| Izumi, Y | 1 |
| Zorumski, CF | 1 |
| Strata, F | 1 |
| Skipper, B | 1 |
| Bulpitt, CJ | 1 |
| Connor, M | 1 |
| Schulte, M | 1 |
| Fletcher, AE | 1 |
| Svechnikov, KV | 1 |
| Sultana, T | 1 |
| Söder, O | 1 |
| Fisher, DR | 1 |
| Strain, J | 1 |
| Gałewski, S | 1 |
| Skangiel-Kramska, J | 1 |
| Pomorski, P | 1 |
| Kossut, M | 1 |
| Miyamoto, A | 1 |
| Maki, T | 1 |
| Blackman, MR | 1 |
| Roth, GS | 1 |
| Howlett, SE | 1 |
| Nicholl, PA | 1 |
| Schmidlin, O | 1 |
| Garcia, J | 1 |
| Schwartz, JB | 1 |
| Khatter, JC | 1 |
| Navaratnam, S | 1 |
| Ruch, S | 1 |
| Kennedy, RH | 1 |
| Seifen, E | 1 |
| Leenen, FH | 1 |
| Yuan, B | 1 |
| Rendt, JM | 1 |
| Toro, L | 1 |
| Stefani, E | 1 |
| Erulkar, SD | 1 |
| Hunt, CM | 1 |
| Westerkam, WR | 1 |
| Stave, GM | 1 |
| Christ, GJ | 1 |
| Maayani, S | 1 |
| Valcic, M | 1 |
| Melman, A | 1 |
| Thompson, LT | 1 |
| Deyo, RA | 1 |
| Disterhoft, JF | 1 |
| Kuwajima, I | 1 |
| Suzuki, Y | 1 |
| Shimosawa, T | 1 |
| Otsuka, K | 1 |
| Kawamura, H | 1 |
| Kuramoto, K | 1 |
| Bravo, EL | 1 |
| Krakoff, LR | 1 |
| Tuck, ML | 1 |
| Friedman, CP | 1 |
| Abernethy, DR | 3 |
| Gutkowska, J | 2 |
| Winterbottom, LM | 1 |
| Nicita-Mauro, V | 1 |
| Imai, Y | 1 |
| Abe, K | 1 |
| Sasaki, S | 1 |
| Minami, N | 1 |
| Nihei, M | 1 |
| Munakata, M | 1 |
| Sakuma, H | 1 |
| Hashimoto, J | 1 |
| Imai, K | 1 |
| Sekino, H | 1 |
| Docherty, JR | 2 |
| Kaĭnova, GM | 1 |
| Markovska, D | 1 |
| Staneva, D | 1 |
| Kagan, VE | 1 |
| Battaini, F | 1 |
| Govoni, S | 1 |
| Rius, RA | 1 |
| Trabucchi, M | 1 |
| Martínez-Serrano, A | 1 |
| Bogónez, E | 1 |
| Vitórica, J | 1 |
| Satrústegui, J | 1 |
| Nayler, WG | 1 |
| Reid, JL | 1 |
| Faulkner, JK | 1 |
| Lambert, MD | 1 |
| Schoeffter, P | 1 |
| Godfraind, T | 1 |
| van Harten, J | 1 |
| Burggraaf, J | 1 |
| Ligthart, GJ | 1 |
| van Brummelen, P | 1 |
| Breimer, DD | 1 |
| Amabile, G | 1 |
| Serradimigni, A | 1 |
| Jullien, T | 1 |
| Verdetti, J | 1 |
| Scott, M | 1 |
| Castleden, CM | 1 |
| Adam, HK | 1 |
| Smith, RP | 1 |
| Fitzsimons, TJ | 1 |
| Robertson, DR | 1 |
| Waller, DG | 1 |
| Renwick, AG | 1 |
| George, CF | 1 |
| Lauterburg, BH | 1 |
| Pruneau, D | 1 |
| Roy, F | 1 |
| Duffy, J | 1 |
| Macdonald, G | 1 |
| Carvajal, A | 1 |
| Franganillo, AM | 1 |
| Alvarez, FJ | 1 |
| Olah, ME | 1 |
| Rahwan, RG | 1 |
| Padrini, R | 1 |
| Piovan, D | 1 |
| Bova, S | 1 |
| Moretto, R | 1 |
| Cargnelli, G | 1 |
| Ferrari, M | 1 |
| Kikuchi, K | 1 |
| Shibata, S | 1 |
| Yamaji, I | 1 |
| Aoki, K | 1 |
| Nozawa, A | 1 |
| Nishimura, M | 1 |
| Tsuchihashi, K | 1 |
| Hasegawa, T | 1 |
| Honma, C | 1 |
| Komura, H | 1 |
| Orimo, H | 1 |
| Terashita, K | 1 |
| Nakamura, T | 1 |
| Ohshima, J | 1 |
| Hermann, P | 1 |
| Morselli, PL | 1 |
| Barst, RJ | 1 |
| Stalcup, SA | 1 |
| Steeg, CN | 1 |
| Hall, JC | 1 |
| Frosolono, MF | 1 |
| Cato, AE | 1 |
| Mellins, RB | 1 |
| Hyland, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A European Multicentre Double-blind Placebo-controlled Phase III Trial of Nilvadipine in Mild to Moderate Alzheimer's Disease[NCT02017340] | Phase 3 | 511 participants (Actual) | Interventional | 2013-04-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for nifedipine and Aging
| Article | Year |
|---|---|
Calcium influx blockers in the treatment of essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Animals; Drug Therapy, Combination; Forearm; Humans | 1984 |
Calcium antagonists. Pharmacokinetic properties.
Topics: Administration, Oral; Aging; Biological Availability; Calcium Channel Blockers; Chemical Phenomena; | 1983 |
Coronary angiogenesis. From morphometry to molecular biology and back.
Topics: Aging; Animals; Capillaries; Coronary Vessels; Growth Substances; Heart; Humans; Inflammation; Model | 1995 |
Nilvadipine. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic use in hypertension and potential in cerebrovascular disease and angina.
Topics: Aging; Angina Pectoris; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cerebrovascular | 1995 |
Clinical pharmacokinetics of nifedipine. Implications for the care of the elderly.
Topics: Aged; Aging; Calcium Channel Blockers; Cost-Benefit Analysis; Delayed-Action Preparations; Dose-Resp | 1997 |
The pharmacokinetic profile of amlodipine.
Topics: Administration, Oral; Aging; Amlodipine; Angina Pectoris; Animals; Biological Availability; Calcium | 1989 |
Pharmacokinetics of diltiazem and other calcium entry blockers.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Benzazepines; Blood Proteins; Calcium Channel Blo | 1985 |
11 trials available for nifedipine and Aging
| Article | Year |
|---|---|
Pharmacokinetics of calcium blockers in patients with renal insufficiency and in geriatric patients.
Topics: Administration, Oral; Adult; Aged; Aging; Diltiazem; Humans; Injections, Intravenous; Kinetics; Male | 1984 |
Nilvadipine increases cerebral blood flow in elderly hypertensives: comparison with nifedipine.
Topics: Aged; Aging; Antihypertensive Agents; Aorta; Cerebrovascular Circulation; Compliance; Cross-Over Stu | 1995 |
Double-blind comparison of amlodipine and nifedipine retard in the treatment of mild to moderate hypertension.
Topics: Adult; Aged; Aging; Amlodipine; Blood Pressure; Double-Blind Method; Drug Administration Schedule; F | 1994 |
Effects of magnesium and nifedipine infusions on insulin action, substrate oxidation, and blood pressure in aged hypertensive patients.
Topics: Aged; Aging; Blood Glucose; Blood Pressure; Body Mass Index; Calcium; Calorimetry; Drug Synergism; E | 1993 |
Blood pressure and progression of renal failure in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; B | 1996 |
Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Aging; Blood Pressure Monitoring, Ambulatory; | 1998 |
A study of losartan, alone or with hydrochlorothiazide vs nifedipine GITS in elderly patients with diastolic hypertension.
Topics: Aged; Aging; Antihypertensive Agents; Calcium Channel Blockers; Diastole; Double-Blind Method; Drug | 1998 |
Bisoprolol and nifedipine retard in elderly hypertensive patients: effect on quality of life.
Topics: Adrenergic beta-Agonists; Affect; Aged; Aging; Antihypertensive Agents; Bisoprolol; Calcium Channel | 2000 |
Antihypertensive effectiveness of nifedipine gastrointestinal therapeutic system in the elderly. The Modern Approach to the Treatment of Hypertension (MATH) Study Group.
Topics: Aged; Aging; Blood Pressure; Cohort Studies; Delayed-Action Preparations; Electrolytes; Female; Hear | 1990 |
A comparison of the disposition of single oral doses of amlodipine in young and elderly subjects.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amlodipine; Blood Pressure; Calcium Channel Blockers; Female; | 1988 |
Comparison of bisoprolol with nifedipine for treatment of essential hypertension in the elderly: comparative double-blind trial.
Topics: Aged; Aging; Bisoprolol; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Heart Rate; | 1987 |
94 other studies available for nifedipine and Aging
| Article | Year |
|---|---|
Characterization of nifedipine-resistant calcium current in neonatal rat ventricular cardiomyocytes.
Topics: Aging; Animals; Animals, Newborn; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Cells | 2000 |
Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice.
Topics: Aging; Animals; Animals, Newborn; Calcium; Calcium Channels, L-Type; Calcium Signaling; Diabetes Mel | 2021 |
Developmental changes in excitation-contraction mechanisms of the mouse ventricular myocardium as revealed by functional and confocal imaging analyses.
Topics: Action Potentials; Aging; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Heart Ventric | 2013 |
Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.
Topics: Aging; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calcium Channel Blockers; Calcium | 2014 |
Hippocampal sharp waves and ripples: Effects of aging and modulation by NMDA receptors and L-type Ca2+ channels.
Topics: Action Potentials; Aging; Animals; Biophysics; Calcium Channel Blockers; Calcium Channels, L-Type; D | 2015 |
Effect of chronic nifedipine treatment on blood pressure and adrenergic responses of isolated mesenteric artery in young rats with developing spontaneous hypertension.
Topics: Age Factors; Aging; Animals; Antihypertensive Agents; Blood Pressure; Calcium; Calcium Channel Block | 2009 |
An N-methyl-D-aspartate-receptor dependent, late-phase long-term depression in middle-aged mice identifies no GluN2-subunit bias.
Topics: Aging; Animals; Calcium Channel Blockers; Diazonium Compounds; Electric Stimulation; Excitatory Amin | 2011 |
Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.
Topics: Aging; Anilides; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Sig | 2011 |
Age-dependent vasorelaxation of Casimiroa edulis and Casimiroa pubescens extracts in rat caudal artery in vitro.
Topics: Age Factors; Aging; Animals; Antihypertensive Agents; Arteries; Casimiroa; Hexanols; Male; Medicine, | 2011 |
17beta-estradiol benzoate decreases the AHP amplitude in CA1 pyramidal neurons.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Electrophysiology; Estr | 2002 |
The role of the sarcoplasmic reticulum in neonatal uterine smooth muscle: enhanced role compared to adult rat.
Topics: Aging; Animals; Animals, Newborn; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calci | 2002 |
Influence of age on combined effects of cyclosporin and nifedipine on rat alveolar bone.
Topics: Administration, Oral; Aging; Alkaline Phosphatase; Alveolar Process; Animals; Bone Density; Bone Mar | 2004 |
Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Aging; Amides; | 2005 |
Effects of chronic administration with nilvadipine against immunohistochemical changes related to aging in the mouse hippocampus.
Topics: Aging; Animals; Calcium Channel Blockers; Cell Death; Cell Proliferation; Cytoprotection; Dose-Respo | 2005 |
Impact of antihypertensive treatments on erectile responses in aging spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Apomorphine; Blood Pressure; Enalapril; Hydralazine; Hydroc | 2006 |
Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node.
Topics: Age Factors; Aging; Animals; Biological Clocks; Calcium; Calcium Channel Blockers; Calcium Channels, | 2007 |
Effects of benidipine and some other calcium channel blockers on the prognosis of patients with vasospastic angina. Cohort study with evaluation of the ergonovine coronary spasm induction test.
Topics: Adult; Aged; Aging; Amlodipine; Angina Pectoris; Calcium Channel Blockers; Cohort Studies; Coronary | 2007 |
Mode of antihypertensive action of nitrendipine.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Diet; Dihydralazine; Heart; Hypertension; H | 1984 |
Comparative effects of verapamil, nifedipine, and diltiazem on contractile function in the isolated immature and adult rabbit heart.
Topics: Aging; Animals; Benzazepines; Calcium; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; My | 1984 |
Post-natal development of functional neurotransmission in rat vas deferens.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Cocaine; Electric Stimulation; In Vitro Techniques; Male; | 1984 |
Ontogenic appearance of Ca2+ channels characterized as binding sites for nitrendipine during development of nervous, skeletal and cardiac muscle systems in the rat.
Topics: Aging; Animals; Brain; Calcium; Calcium Channel Blockers; Fetus; Heart; Ion Channels; Kinetics; Musc | 1983 |
Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine (PY 108-068) on the cerebral capillary network in aged rats.
Topics: Aging; Alkaline Phosphatase; Analysis of Variance; Animals; Calcium Channel Blockers; Capillaries; C | 1995 |
Characterization of pharmacologically identified voltage-gated calcium channel currents in acutely isolated rat neocortical neurons. II. Postnatal development.
Topics: Aging; Animals; Barium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cerebr | 1995 |
Shaker-related potassium channel, Kv1.4, mRNA regulation in cultured rat heart myocytes and differential expression of Kv1.4 and Kv1.5 genes in myocardial development and hypertrophy.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Age-dependent expression of high-voltage activated calcium currents during cerebellar granule cell development in situ.
Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels; Cerebellum; Electrophysiology; In Vitro | 1994 |
Age-related changes in brain microanatomy: sensitivity to treatment with the dihydropyridine calcium channel blocker darodipine (PY 108-068).
Topics: Aging; Alkaline Phosphatase; Animals; Brain; Calcium Channel Blockers; Lipofuscin; Male; Neurons; Ni | 1995 |
Na+/Ca2+ exchange and cell contraction in isolated neonatal and adult rabbit cardiac myocytes.
Topics: Aging; Animals; Animals, Newborn; Calcium Channel Blockers; Carrier Proteins; Electrophysiology; Myo | 1995 |
Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of calbindin D-28K immunoreactivity in the cerebellar cortex of aged rats.
Topics: Aging; Animals; Calbindins; Calcium Channel Blockers; Cerebellar Cortex; Immunohistochemistry; Male; | 1995 |
The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Clonidine; Dioxanes; Hypertension; In | 1995 |
Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of neurofilament protein immunoreactivity in the cerebellar cortex of aged rats.
Topics: Aging; Animals; Calcium Channel Blockers; Cerebellar Cortex; Immunohistochemistry; Male; Neurofilame | 1994 |
Effects of dietary restriction on the change in aortic alpha 1-adrenoceptor mediated responses during aging in Fischer 344 rats.
Topics: Aging; Animals; Aorta; Calcium; Diet; Energy Intake; Inositol Phosphates; Male; Nifedipine; Norepine | 1995 |
Retinal ganglion neurons express a toxin-resistant developmentally regulated novel type of high-voltage-activated calcium channel.
Topics: Aging; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels; Drug Resistance; Membr | 1994 |
Effect of calcium antagonists on isolated aorta from hypercholesterolemic Yoshida rats of different ages.
Topics: Aging; Animals; Aorta, Thoracic; Dinoprostone; Hypercholesterolemia; In Vitro Techniques; Male; Musc | 1994 |
Influence of age on control of norepinephrine release: Ca2+ channels and dopamine D2 receptors.
Topics: Aging; Animals; Arteries; Calcium Channel Blockers; Calcium Channels; Dopamine Agents; In Vitro Tech | 1994 |
Insulin secretion by the pancreatic beta cell of aged rats.
Topics: Aging; Animals; Colforsin; Dose-Response Relationship, Drug; Glucose; Glyburide; In Vitro Techniques | 1994 |
Arterial smooth muscle responses in adult and moderately aged spontaneously hypertensive rats.
Topics: Aging; Aminoquinolines; Animals; Blood Platelets; Calcium; Endothelium, Vascular; Hypertension; Lymp | 1994 |
Ca(2+)-conductances in cultured rat retinal pigment epithelial cells.
Topics: Aging; Animals; Calcium Channels; Cell Membrane; Cells, Cultured; Membrane Potentials; Nifedipine; P | 1994 |
Influence of long-term treatment with nifedipine on blood pressure, left ventricular mass and cardiac arrhythmias in elderly hypertensive patients.
Topics: Aged; Aged, 80 and over; Aging; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Circadian Rhyt | 1994 |
Prevention of age-related V1 myosin isozyme decrement in the adult rat heart.
Topics: Aging; Animals; Gene Expression Regulation, Enzymologic; Heart; Hemodynamics; Isoenzymes; Myocardium | 1994 |
Intraglomerular expression of alpha-smooth muscle actin in aging mice.
Topics: Actins; Aging; Animals; Enalapril; Kidney Glomerulus; Mice; Mice, Inbred Strains; Muscle, Smooth; Ni | 1994 |
Influence of aging on the beta- and glucagon-receptor-mediated glycogenolysis in rat hepatocytes.
Topics: Aging; Animals; Calcium; Egtazic Acid; Enzyme Activation; In Vitro Techniques; Liver; Liver Glycogen | 1993 |
Alterations in cardiac myosin isozymes associated with aging and chronic hypertension: their modulation with nifedipine.
Topics: Aging; Animals; Chronic Disease; Electrophoresis, Polyacrylamide Gel; Hypertension; Hypertrophy, Lef | 1993 |
Renal interstitial sclerosis in aging: effects of enalapril and nifedipine.
Topics: Actins; Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Biomarkers; Calcium Channel Blocke | 1996 |
Influence of age on the relaxation induced by nifedipine in aorta from spontaneously hypertensive and Wistar Kyoto rats.
Topics: Aging; Animals; Aorta; Endothelium, Vascular; Hypertension; Male; Muscle Contraction; Muscle, Smooth | 1995 |
Novel modulatory effect of L-type calcium channels at newly formed neuromuscular junctions.
Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Evoked Potentials; GT | 1997 |
Characterization of in vitro relaxant mechanisms in erectile tissue from rabbits of different ages.
Topics: Acetylcholine; Aging; Animals; Calcium Channel Blockers; In Vitro Techniques; Male; Muscle Contracti | 1996 |
Alpha-adrenoceptor activation induces rhythmic contractile activity in carotid arteries from young, not adult, rats.
Topics: Aging; Animals; Animals, Newborn; Calcium Channel Blockers; Carotid Arteries; Enzyme Inhibitors; Fem | 1997 |
Oxidant injury in PC12 cells--a possible model of calcium "dysregulation" in aging: I. Selectivity of protection against oxidative stress.
Topics: Aging; Animals; Antioxidants; Calcium; Cell Survival; Chromans; Cyclic N-Oxides; Dose-Response Relat | 1997 |
Aging differentially alters forms of long-term potentiation in rat hippocampal area CA1.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Calcium Channels; Calcium Channels, N-Type; Electric St | 1998 |
Influence of postnatal changes in action potential duration on Na-Ca exchange in rabbit ventricular myocytes.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Calcium Channel Blockers; Cell Size; Electric C | 1998 |
Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels.
Topics: Aging; Animals; Apamin; Calcium Channel Blockers; Electric Stimulation; Hippocampus; In Vitro Techni | 1998 |
Developmental changes in the expression of low-voltage-activated Ca2+ channels in rat visual cortical neurones.
Topics: Aging; Animals; Animals, Newborn; Calcium Channels; Evoked Potentials; Gene Expression Regulation, D | 1998 |
Ca2+ signaling in fowl aortic smooth muscle increases during maturation but is impaired in neointimal plaques.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |
LTP in CA1 of the adult rat hippocampus and voltage-activated calcium channels.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dizoc | 1998 |
Intrinsic oscillations in CA3 hippocampal pyramids: physiological relevance to theta rhythm generation.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Calcium; Calcium Channels; Carbachol; Cesium; Hip | 1998 |
Age-related difference in cardiac adaptation to chronic hypertension in rats, with and without nifedipine treatment.
Topics: Adaptation, Physiological; Aging; Animals; Antihypertensive Agents; Hypertension; Nifedipine; Rats; | 1999 |
Age-dependent stimulation of Leydig cell steroidogenesis by interleukin-1 isoforms.
Topics: Aging; Animals; Bucladesine; Cell Division; Enzyme Inhibitors; Interleukin-1; Isoquinolines; Leydig | 2001 |
Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells.
Topics: Aging; Animals; Antioxidants; Calcium; Calcium Channel Blockers; Cell Survival; Chlorocebus aethiops | 2002 |
Voltage-dependent L-type calcium channels in the development and plasticity of mouse barrel cortex.
Topics: Aging; Animals; Autoradiography; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; D | 1992 |
Age-related changes in the mechanisms of LHRH-stimulated LH release from pituitary cells in vitro.
Topics: Aging; Analysis of Variance; Animals; Buserelin; Calcimycin; Calcium Channels; Cells, Cultured; Gona | 1992 |
Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters.
Topics: Aging; Allosteric Site; Animals; Calcium Channels; Cricetinae; Dihydropyridines; Diltiazem; In Vitro | 1992 |
The effects of aging on the electrophysiologic and hemodynamic responses to nifedipine in isolated perfused hearts.
Topics: Aging; Animals; Blood Pressure; Dose-Response Relationship, Drug; Electrophysiology; Hemodynamics; I | 1992 |
Enhancement in myocardial inotropic response to BAY K 8644 with advancing age.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Aging: inotropic effects of Bay K-8644 and nifedipine on rat cardiac muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Dietary sodium and the antihypertensive effect of nifedipine in spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Heart Ventricles; Hemodynamics; | 1992 |
Progesterone increases Ca2+ currents in myometrial cells from immature and nonpregnant adult rats.
Topics: Aging; Animals; Barium; Calcium; Calcium Channel Blockers; Cells, Cultured; Electrophysiology; Estro | 1992 |
Effect of age and gender on the activity of human hepatic CYP3A.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; | 1992 |
Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Effect of nifedipine tablets on ambulatory blood pressure in patients aged less than 60 and greater than 65 years with systemic hypertension.
Topics: Aged; Aging; Blood Pressure; Blood Pressure Monitors; Circadian Rhythm; Dose-Response Relationship, | 1991 |
Effects of amlodipine, a long-acting dihydropyridine calcium antagonist in aging hypertension: pharmacodynamics in relation to disposition.
Topics: Administration, Oral; Adult; Aged; Aging; Amlodipine; Atrial Natriuretic Factor; Blood Pressure; Cal | 1990 |
Smoking, calcium, calcium antagonists, and aging.
Topics: Aged; Aging; Blood Vessels; Calcitonin; Calcium; Humans; Nifedipine; Smoking; Vasoconstriction | 1990 |
Influence of age on the nocturnal fall of blood pressure and its modulation by long-acting calcium antagonists.
Topics: Aging; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Humans; Monitoring, Physiologic; | 1990 |
Age-related differences in the depressor responses to sodium nitroprusside and nifedipine in anaesthetized rats.
Topics: Aging; Animals; Blood Pressure; Ferricyanides; Heart Rate; Isoproterenol; Male; Nifedipine; Nitropru | 1990 |
[Activation of endogenous lipid peroxidation in the brain in oxidation stress caused by administration of iron and its prevention by vitamin E].
Topics: Administration, Oral; Aging; Animals; Brain; Fluorescence; Injections, Intramuscular; Iron; Lipid Pe | 1990 |
Age-dependent increase in [3H]verapamil binding to rat cortical membranes.
Topics: Age Factors; Aging; Animals; Binding, Competitive; Calcium; Cerebral Cortex; Ion Channels; Male; Mem | 1985 |
Reduction of K+-stimulated 45Ca2+ influx in synaptosomes with age involves inactivating and noninactivating calcium channels and is correlated with temporal modifications in protein dephosphorylation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
The effect of amlodipine on hypertension-induced cardiac hypertrophy and reperfusion-induced calcium overload.
Topics: Aging; Amlodipine; Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Cardiomegaly; Coronar | 1988 |
Amlodipine in elderly hypertensive patients: pharmacokinetics and pharmacodynamics.
Topics: Adult; Aged; Aging; Amlodipine; Blood Pressure; Calcium Channel Blockers; Female; Half-Life; Hormone | 1988 |
Spontaneous rhythmic contractions of human saphenous veins isolated from old subjects are sensitive to cyclooxygenase inhibitors.
Topics: Adult; Aged; Aging; Aspirin; Coronary Artery Bypass; Cyclooxygenase Inhibitors; Female; Histamine; H | 1989 |
Single- and multiple-dose nisoldipine kinetics and effects in the young, the middle-aged, and the elderly.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Dose-Response Relations | 1989 |
Comparative electrophysiological response of young and old rat myocardium to pharmacological agents.
Topics: Action Potentials; Aging; Amiloride; Animals; Electric Stimulation; Female; Heart; Isoproterenol; Ni | 1988 |
The effect of ageing on the disposition of nifedipine and atenolol.
Topics: Adolescent; Adult; Aged; Aging; Atenolol; Blood Pressure; Creatinine; Female; Heart Rate; Humans; Ma | 1988 |
Age-related changes in the pharmacokinetics and pharmacodynamics of nifedipine.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Biological Availability; Blood Pressure | 1988 |
[Clinical pharmacology of calcium antagonists].
Topics: Aging; Arrhythmias, Cardiac; Biological Availability; Calcium Channel Blockers; Diltiazem; Drug Inte | 1987 |
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Nicardipine; Nife | 1987 |
The antihypertensive efficacy of nifedipine alone and in combination in general practice.
Topics: Adult; Aged; Aging; Blood Pressure; Drug Therapy, Combination; Family Practice; Female; Follow-Up St | 1987 |
Verapamil and nifedipine effect on K+-induced contractions of guinea pig ileum during postnatal development.
Topics: Aging; Animals; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; | 1987 |
Age-related changes in responsiveness of the rat aorta to depolarizing and receptor-mediated contractile stimuli and to calcium antagonism.
Topics: Aging; Animals; Aorta; Calcium Channel Blockers; Indenes; Muscle Contraction; Nifedipine; Norepineph | 1987 |
Physiological, pharmacological and pathological factors affecting the pharmacokinetics of calcium entry blockers.
Topics: Aging; Animals; Calcium Channel Blockers; Diltiazem; Drug Administration Schedule; Guinea Pigs; Huma | 1987 |
[Enhanced hypotensive effect of long-acting nifedipine on elder patients with mild or moderate essential hypertension].
Topics: Adult; Age Factors; Aged; Aging; Benzothiadiazines; Delayed-Action Preparations; Diuretics; Drug The | 1986 |
Ca and atherosclerosis.
Topics: Aged; Aging; Animals; Aorta; Arteries; Arteriosclerosis; Bone Diseases; Calcinosis; Calcium; Calcium | 1985 |
Relation of arachidonate metabolites to abnormal control of the pulmonary circulation in a child.
Topics: 6-Ketoprostaglandin F1 alpha; Aging; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Diltiazem; | 1985 |
Further examination of the effects of ageing on the adrenoceptor responsiveness of the rat vas deferens.
Topics: Aging; Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Male; M | 1985 |