nifedipine has been researched along with Acidosis in 16 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of diltiazem, verapamil, and nifedipine on extracellular potassium concentration ([K+]e), acidosis, and level of metabolic markers were examined during 30-min global ischemia and postischemic left ventricular (LV) function in isolated guinea pig hearts." | 3.70 | Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts. ( Nagao, T; Sato, R; Yamazaki, J, 1999) |
| "Our purpose was to determine whether the fetal acidosis and hypoxia previously demonstrated in animal models with maternal nifedipine infusion is the result of a decrease in uteroplacental or fetoplacental blood flow and whether this effect is exacerbated by a higher drug concentration and duration of infusion." | 3.69 | Effect of nifedipine on fetal and maternal hemodynamics and blood gases in the pregnant ewe. ( Barnard, JM; Blea, CW; Hendricks, SK; Magness, RR; Phernetton, TM, 1997) |
| ") administered nifedipine were studied in chloralose-anaesthetized rats subjected to hypoxaemia, hyperoxaemia, alkalosis, acidosis, hypocarbia with alkalosis, or hypercarbia with acidosis." | 3.68 | Cardiovascular responses to nifedipine in anaesthetized rats with abnormal blood gas/pH levels. ( Achike, FI; Dai, S, 1991) |
| " These studies have now been extended to compare the relative sensitization by acidosis of verapamil, nifedipine, lidoflazine, perhexilene and diltiazem." | 3.67 | The relative sensitization by acidosis of five calcium blockers in cat papillary muscles. ( Briscoe, MG; Smith, HJ, 1985) |
| "Acidosis accompanying cerebral ischemia activates acid-sensing ion channels (ASIC) causing increases in intracellular calcium concentration ([Ca(2+)]i) and enhanced neuronal death." | 1.36 | ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis. ( Cuevas, J; Katnik, C; Mari, Y, 2010) |
| "Amlodipine is a long-acting dihydropyridine-based Ca2+ channel blocker, developed for use on a once-daily basis." | 1.28 | Amlodipine pretreatment and the ischemic heart. ( Nayler, WG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zeng, X | 1 |
| Zhang, Y | 1 |
| Qing, C | 1 |
| Zhang, H | 1 |
| Torring, MS | 1 |
| Holmgaard, K | 1 |
| Hessellund, A | 1 |
| Aalkjaer, C | 1 |
| Bek, T | 1 |
| Cheng, H | 1 |
| Smith, GL | 1 |
| Orchard, CH | 1 |
| Hancox, JC | 1 |
| Mari, Y | 1 |
| Katnik, C | 1 |
| Cuevas, J | 1 |
| Cho, YE | 1 |
| Ahn, DS | 1 |
| Kim, YH | 1 |
| Taggart, MJ | 1 |
| Lee, YH | 1 |
| Kimura, S | 1 |
| Nakaya, H | 1 |
| Kanno, M | 1 |
| Blea, CW | 1 |
| Barnard, JM | 1 |
| Magness, RR | 1 |
| Phernetton, TM | 1 |
| Hendricks, SK | 1 |
| Sato, R | 1 |
| Yamazaki, J | 1 |
| Nagao, T | 1 |
| McGillivray-Anderson, KM | 1 |
| Faber, JE | 1 |
| Achike, FI | 1 |
| Dai, S | 1 |
| Nayler, WG | 1 |
| Robertson, MJ | 1 |
| Lumley, P | 1 |
| Gende, OA | 1 |
| Camilión de Hurtado, MC | 1 |
| Rinaldi, GJ | 1 |
| Amado Cattaneo, E | 1 |
| Cingolani, HE | 1 |
| Feltes, TF | 1 |
| Fike, CD | 1 |
| Hansen, TN | 1 |
| Smith, HJ | 1 |
| Briscoe, MG | 1 |
16 other studies available for nifedipine and Acidosis
| Article | Year |
|---|---|
L-type Ca2+ channel blocker attenuates impairment induced by acidosis in hippocampal neurons.
Topics: Acidosis; Amiloride; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; | 2013 |
The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibition.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetazolamide; Acidosis; Animals | 2009 |
Acidosis inhibits spontaneous activity and membrane currents in myocytes isolated from the rabbit atrioventricular node.
Topics: Acidosis; Animals; Atrioventricular Node; Calcium Channels, L-Type; Electrophysiology; Hydrogen-Ion | 2009 |
ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis.
Topics: 2-Amino-5-phosphonovalerate; Acid Sensing Ion Channels; Acidosis; Animals; Brain Ischemia; Calcium; | 2010 |
Changes in stretch-induced tone induced by intracellular acidosis in rabbit basilar artery: effects on BKCa channel activity.
Topics: Acidosis; Animals; Basilar Artery; Calcium; Female; Hydrogen-Ion Concentration; Male; Muscle Tonus; | 2007 |
Electrophysiological effects of diltiazem, nifedipine and Ni2+ on the subepicardial muscle cells of canine heart under the condition of combined hypoxia, hyperkalemia and acidosis.
Topics: Acidosis; Action Potentials; Animals; Benzazepines; Calcium Channel Blockers; Diltiazem; Dogs; Femal | 1983 |
Effect of nifedipine on fetal and maternal hemodynamics and blood gases in the pregnant ewe.
Topics: Acidosis; Animals; Bicarbonates; Female; Fetal Blood; Fetal Diseases; Fetus; Half-Life; Hemodynamics | 1997 |
Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts.
Topics: Acidosis; Adenosine Triphosphate; Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem | 1999 |
Effect of reduced blood flow on alpha 1- and alpha 2-adrenoceptor constriction of rat skeletal muscle microvessels.
Topics: Acidosis; Animals; Clonidine; Male; Microcirculation; Muscles; Nifedipine; Rats; Rats, Inbred Strain | 1991 |
Cardiovascular responses to nifedipine in anaesthetized rats with abnormal blood gas/pH levels.
Topics: Acidosis; Alkalosis; Animals; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Cardiovascular Sys | 1991 |
Amlodipine pretreatment and the ischemic heart.
Topics: Acidosis; Adenosine Triphosphate; Amlodipine; Animals; Calcium; Calcium Channel Blockers; Coronary D | 1989 |
Effects of hypoxia, elevated K+ and acidosis on the potency of verapamil, diltiazem and nifedipine in the guinea-pig isolated papillary muscle.
Topics: Acidosis; Animals; Cell Hypoxia; Coronary Disease; Diltiazem; Dinitrophenols; Electric Stimulation; | 1989 |
[Increase of the depressive effect of verapamil in acidosis].
Topics: Acidosis; Animals; Depression, Chemical; Heart Atria; Hydrogen-Ion Concentration; Myocardial Contrac | 1986 |
Interaction between calcium and hydrogen ions in canine coronary arteries.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Animals; Calcium; Coronary Vessels; Dogs; Endothelium, V | 1987 |
Effects of dopamine and nifedipine infusions on the pulmonary circulation of the lamb.
Topics: Acidosis; Animals; Blood Pressure; Cardiac Output; Dopamine; Hypoxia; Nifedipine; Pulmonary Circulat | 1986 |
The relative sensitization by acidosis of five calcium blockers in cat papillary muscles.
Topics: Acidosis; Animals; Calcium Channel Blockers; Cats; Diltiazem; In Vitro Techniques; Lidoflazine; Myoc | 1985 |