nifedipine has been researched along with Absence Seizure in 33 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Magnesium sulfate may prevent eclampsia by reducing cerebral vasoconstriction and ischemia." | 9.10 | A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. ( Allen, JC; Anthony, J; Belfort, MA; Saade, GR, 2003) |
| " The purpose of the present study was to evaluate the effects of nifedipine, a calcium channel blocker, on epileptic seizures and on reperfusion arrhythmias in rats prone to audiogenic epileptic seizures (Wistar audiogenic rats, WAR) and in normal Wistar rats (N = 6/group)." | 7.78 | Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures. ( Almeida, AP; Damasceno, DD; Doretto, MC; Ferreira, AJ, 2012) |
| "The calcium-channel inhibitor nifedipine and several anticonvulsant drugs were evaluated for effects on seizures induced by intracerebroventricular injection of 0." | 7.68 | Effect of nifedipine and anticonvulsants on kainic acid-induced seizures in mice. ( Braun, DE; Freed, WJ, 1990) |
| "Nifedipine was found to have anticonvulsant activity in both models but flunarizine only had an anticonvulsant effect in the PTZ seizure incidence/latency test." | 5.29 | Protective effect of flunarizine and nifedipine alone and in combination with anticonvulsant drugs against PTZ-induced seizures in mice. ( Pleuvry, BJ; Rodger, C, 1993) |
| "Pretreatment with nifedipine (7." | 5.28 | Seizures and wet-dog shakes induced by 4-aminopyridine, and their potentiation by nifedipine. ( Alvarado, R; Fragoso-Veloz, J; Massieu, L; Tapia, R, 1990) |
| "Magnesium sulfate may prevent eclampsia by reducing cerebral vasoconstriction and ischemia." | 5.10 | A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. ( Allen, JC; Anthony, J; Belfort, MA; Saade, GR, 2003) |
| " The purpose of the present study was to evaluate the effects of nifedipine, a calcium channel blocker, on epileptic seizures and on reperfusion arrhythmias in rats prone to audiogenic epileptic seizures (Wistar audiogenic rats, WAR) and in normal Wistar rats (N = 6/group)." | 3.78 | Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures. ( Almeida, AP; Damasceno, DD; Doretto, MC; Ferreira, AJ, 2012) |
| "A series of appropriate alkanolamine and amide derivatives of xanthone were prepared and evaluated for anticonvulsant activity using maximal electroshock (MES) and subcutaneous pentylenetetrazole (scMet) induced seizures, and for neurotoxicity (TOX) using the rotorod test on mice and rats." | 3.74 | Anticonvulsant activity of some xanthone derivatives. ( Antkiewicz-Michaluk, L; Marona, H; Pekala, E; Szneler, E; Walczak, M, 2008) |
| " Application of APV and nifedipine exacerbated low Mg(2+)-induced ILEs in the hippocampus but not the neocortex, indicating a distinct pharmacology for partial seizures of different brain regions." | 3.73 | Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL, 2005) |
| "Death from cocaine intoxication results from one or more of the multiple mechanisms including seizures, cardiovascular collapse, or apnea." | 3.68 | Acute cocaine toxicity: the effect of agents in non-seizure-induced death. ( Albertson, TE; Derlet, RW; Tseng, CC, 1993) |
| "The calcium-channel inhibitor nifedipine and several anticonvulsant drugs were evaluated for effects on seizures induced by intracerebroventricular injection of 0." | 3.68 | Effect of nifedipine and anticonvulsants on kainic acid-induced seizures in mice. ( Braun, DE; Freed, WJ, 1990) |
| "The effects of chemically and electrically-evoked seizures on [3H]nitrendipine binding to voltage-dependent calcium channels in mouse brain were determined 30 and 60 min following the initiation of convulsions." | 3.67 | The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain. ( Bolger, GT; Weissman, BA, 1987) |
| "Three calcium channel blockers were studied for efficacy in preventing seizures and death from cocaine intoxication." | 3.67 | Potentiation of cocaine toxicity with calcium channel blockers. ( Albertson, TE; Derlet, RW, 1989) |
| "Cortical dysplasia is the most common etiology of intractable epilepsy." | 1.48 | Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia. ( Feng, L; Wang, YL; Xiao, B; Yue, ZW, 2018) |
| "The drug (20 mg/kg) inhibited clonic seizure in four of six of the animals and abolished minimal or maximal tonic seizures in all the animals." | 1.33 | Nifedipine inhibits picrotoxin-induced seizure activity: further evidence on the involvement of L-type calcium channel blockers in epilepsy. ( Hasan, Z; Otoom, S, 2006) |
| "Posterior reversible encephalopathy syndrome (PRES) is an acronym that identifies a new clinico-neuroradiologic entity occurring in association with different conditions." | 1.33 | PRES: posterior or potentially reversible encephalopathy syndrome? ( Abbate, M; Ferlazzo, E; Granata, F; Mazzù, I; Musolino, R; Narbone, MC, 2006) |
| "The ED50 of W-7 to antagonize convulsions induced by lindane and BAY-K-8644 were 12 (8-19) mg/kg and 49 (29-85) mg/kg, respectively." | 1.29 | Anticonvulsant activity of delta-HCH, calcium channel blockers and calmodulin antagonists in seizures induced by lindane and other convulsant drugs. ( Barrón, S; Serratosa, J; Tusell, JM, 1993) |
| "Flunarizine was also the only drug that antagonized methamphetamine-induced stereotypy." | 1.29 | Effects of L-type calcium channel antagonists on the serotonin-depleting actions of MDMA in rats. ( Calder, L; Clikeman, J; Finnegan, KT; Karler, R; Wei, S, 1993) |
| " Chronic administration of electroconvulsive shock (once daily for 8 days) produced hyperalgesia, augmented locomotor responses to low doses of apomorphine and upregulation of cortical (but not hippocampal) voltage-dependent Ca2+ channels (assessed from [3H]nitrendipine binding)." | 1.29 | Modification of effects of chronic electroconvulsive shock by voltage-dependent Ca2+ channel blockade with nifedipine. ( Antkiewicz-Michaluk, L; Michaluk, J; Vetulani, J, 1994) |
| "Nifedipine was found to have anticonvulsant activity in both models but flunarizine only had an anticonvulsant effect in the PTZ seizure incidence/latency test." | 1.29 | Protective effect of flunarizine and nifedipine alone and in combination with anticonvulsant drugs against PTZ-induced seizures in mice. ( Pleuvry, BJ; Rodger, C, 1993) |
| "The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s." | 1.29 | Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. ( Satishchandra, P; Shankar, SK; Ullal, GR, 1996) |
| "Furthermore, (+)MK-801 antagonized seizures induced by either lindane, PTX or PTZ with similar potencies in both mouse lines." | 1.28 | Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers. ( Serratosa, J; Trullas, R; Tusell, JM; Vendrell, M, 1992) |
| "Nimodipine did not affect convulsions elicited by strychnine." | 1.28 | The effects of dihydropyridine calcium channel modulators on pentylenetetrazole convulsions. ( Bolger, GT; O'Neill, SK, 1990) |
| "Pretreatment with nifedipine (7." | 1.28 | Seizures and wet-dog shakes induced by 4-aminopyridine, and their potentiation by nifedipine. ( Alvarado, R; Fragoso-Veloz, J; Massieu, L; Tapia, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.09) | 18.7374 |
| 1990's | 22 (66.67) | 18.2507 |
| 2000's | 5 (15.15) | 29.6817 |
| 2010's | 3 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marona, H | 1 |
| Pekala, E | 1 |
| Antkiewicz-Michaluk, L | 2 |
| Walczak, M | 1 |
| Szneler, E | 1 |
| Prasanthi, G | 1 |
| Prasad, KV | 1 |
| Bharathi, K | 1 |
| Yue, ZW | 1 |
| Wang, YL | 1 |
| Xiao, B | 1 |
| Feng, L | 1 |
| Damasceno, DD | 1 |
| Ferreira, AJ | 1 |
| Doretto, MC | 1 |
| Almeida, AP | 1 |
| Belfort, MA | 1 |
| Anthony, J | 1 |
| Saade, GR | 1 |
| Allen, JC | 1 |
| Abdelmalik, PA | 1 |
| Burnham, WM | 1 |
| Carlen, PL | 1 |
| Otoom, S | 1 |
| Hasan, Z | 1 |
| Narbone, MC | 1 |
| Musolino, R | 1 |
| Granata, F | 1 |
| Mazzù, I | 1 |
| Abbate, M | 1 |
| Ferlazzo, E | 1 |
| Tusell, JM | 2 |
| Barrón, S | 1 |
| Serratosa, J | 2 |
| Finnegan, KT | 1 |
| Calder, L | 1 |
| Clikeman, J | 1 |
| Wei, S | 1 |
| Karler, R | 1 |
| Michaluk, J | 1 |
| Vetulani, J | 1 |
| Mizoguchi, H | 1 |
| Yoshiike, M | 1 |
| Suzuki, T | 1 |
| Misawa, M | 1 |
| Tseng, CC | 1 |
| Derlet, RW | 2 |
| Albertson, TE | 2 |
| Kryzhanovskiĭ, GN | 2 |
| Karpova, MN | 2 |
| Abrosimov, IIu | 1 |
| Rodger, C | 1 |
| Pleuvry, BJ | 1 |
| Ullal, GR | 1 |
| Satishchandra, P | 1 |
| Shankar, SK | 1 |
| Gasior, M | 1 |
| Borowicz, K | 1 |
| Kleinrok, Z | 2 |
| Starownik, R | 1 |
| Czuczwar, SJ | 2 |
| Garibova, TL | 1 |
| Val'dman, EA | 1 |
| Voronina, TA | 1 |
| Kraĭneva, VA | 1 |
| Raju, SS | 1 |
| Gopalakrishna, HN | 1 |
| Venkatadri, N | 1 |
| Pearson, ER | 1 |
| D'Souza, RJ | 1 |
| Hamilton-Wood, C | 1 |
| Nicholls, AJ | 1 |
| Beaman, M | 1 |
| Vendrell, M | 1 |
| Trullas, R | 1 |
| Kalynchuk, LE | 1 |
| Dalal, S | 1 |
| Mana, MJ | 1 |
| Pinel, JP | 1 |
| O'Neill, SK | 2 |
| Bolger, GT | 3 |
| Pankov, OIu | 1 |
| Glebov, RN | 1 |
| Bahls, FH | 1 |
| Ozuna, J | 1 |
| Ritchie, DE | 1 |
| Braun, DE | 1 |
| Freed, WJ | 1 |
| Małek, U | 1 |
| Fragoso-Veloz, J | 1 |
| Massieu, L | 1 |
| Alvarado, R | 1 |
| Tapia, R | 1 |
| Wells, TG | 1 |
| Graham, CJ | 1 |
| Moss, MM | 1 |
| Kearns, GL | 1 |
| Sklenovský, A | 1 |
| Navrátil, J | 1 |
| Chmela, Z | 1 |
| Weissman, BA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Labetalol Versus MgSO4 for the Prevention of Eclampsia Trial (LAMPET)[NCT00293735] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2015-06-30 | Withdrawn (stopped due to Lack of funding) | ||
| A Novel Protocol for Postpartum Magnesium Sulfate in Severe Preeclampsia When the Woman Received Less That 8 Hours Before Delivery. Six Versus Twenty-four Hours Postpartum[NCT02317146] | Phase 2/Phase 3 | 280 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia Receiving Treatment for More Than 8 Hours Before Delivery. A Randomized Multicenter Clinical Trial .[NCT02307201] | Phase 2/Phase 3 | 1,114 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for nifedipine and Absence Seizure
| Article | Year |
|---|---|
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul | 2003 |
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul | 2003 |
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul | 2003 |
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul | 2003 |
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul | 2003 |
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul | 2003 |
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul | 2003 |
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul | 2003 |
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul | 2003 |
32 other studies available for nifedipine and Absence Seizure
| Article | Year |
|---|---|
Anticonvulsant activity of some xanthone derivatives.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Mice; Molecular Structure; | 2008 |
Synthesis, anticonvulsant activity and molecular properties prediction of dialkyl 1-(di(ethoxycarbonyl)methyl)-2,6-dimethyl-4-substituted-1,4-dihydropyridine-3,5-dicarboxylates.
Topics: Administration, Oral; Animals; Anticonvulsants; Dihydropyridines; Drug Design; Male; Mice; Molecular | 2014 |
Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia.
Topics: Animals; Axon Initial Segment; Axons; Disease Models, Animal; Disease Susceptibility; Electroencepha | 2018 |
Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Diseas | 2012 |
Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers | 2005 |
Nifedipine inhibits picrotoxin-induced seizure activity: further evidence on the involvement of L-type calcium channel blockers in epilepsy.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Convulsants; Dose-Response Relationship | 2006 |
PRES: posterior or potentially reversible encephalopathy syndrome?
Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Antihypertensive Agents; Brain; Brain Diseases; Cl | 2006 |
Anticonvulsant activity of delta-HCH, calcium channel blockers and calmodulin antagonists in seizures induced by lindane and other convulsant drugs.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Calmodulin; Convulsants; Hexachlorocyclohexane; | 1993 |
Effects of L-type calcium channel antagonists on the serotonin-depleting actions of MDMA in rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Calcium Channel Blockers; Cerebral Cortex; | 1993 |
Modification of effects of chronic electroconvulsive shock by voltage-dependent Ca2+ channel blockade with nifedipine.
Topics: Animals; Apomorphine; Behavior, Animal; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; | 1994 |
Effects of Ca2+ channel blockers on physical dependence on diazepam in mice.
Topics: Animals; Brain; Calcium Channel Blockers; Carbolines; Diazepam; Diltiazem; Drug Interactions; Flunar | 1993 |
Acute cocaine toxicity: the effect of agents in non-seizure-induced death.
Topics: Animals; Anticonvulsants; Cocaine; Diazepam; Electrodes, Implanted; Electroencephalography; Male; Ni | 1993 |
[The anticonvulsive activity of the 1,4-dihydropyridine derivative riodipine and other anticonvulsants when used in combination].
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; E | 1993 |
Protective effect of flunarizine and nifedipine alone and in combination with anticonvulsant drugs against PTZ-induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Ethosu | 1993 |
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electr | 1996 |
Anticonvulsant and adverse effects of MK-801, LY 235959, and GYKI 52466 in combination with Ca2+ channel inhibitors in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Benzodiazepines; Calcium Channel | 1997 |
[Effect of calcium channel blocker nifedipine on anxiety and seizure manifestations of abstinence syndrome in rats after withdrawal of long-term diazepam administration].
Topics: Adaptation, Physiological; Animals; Anti-Anxiety Agents; Anxiety; Calcium Channel Blockers; Calcium | 1998 |
Effect of propranolol and nifedipine on maximal electroshock-induced seizures in mice: individually and in combination.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Nifedipine; Ph | 1998 |
Hypertensive encephalopathy and nephrotic syndrome: a possible link?
Topics: Anti-Inflammatory Agents; Antihypertensive Agents; Azathioprine; Brain Diseases; Calcium Channel Blo | 1999 |
Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Dizocilpine Maleate; Dose-Response | 1992 |
Nifedipine blocks the development of tolerance to the anticonvulsant effects of ethanol.
Topics: Animals; Anticonvulsants; Drug Tolerance; Electric Stimulation; Ethanol; Forelimb; Kindling, Neurolo | 1992 |
The effects of dihydropyridine calcium channel modulators on pentylenetetrazole convulsions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
[Antiepileptic effects of nifedipine].
Topics: Animals; Anticonvulsants; Cerebral Cortex; Epilepsies, Partial; Kindling, Neurologic; Male; Nifedipi | 1991 |
Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Carbamazepine; Diltiazem; Drug Interactions; Female | 1991 |
Effect of nifedipine and anticonvulsants on kainic acid-induced seizures in mice.
Topics: Animals; Anticonvulsants; Female; Kainic Acid; Mice; Nifedipine; Reaction Time; Seizures | 1990 |
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Ethosuximi | 1990 |
Seizures and wet-dog shakes induced by 4-aminopyridine, and their potentiation by nifedipine.
Topics: 4-Aminopyridine; Animals; Behavior, Animal; Drug Synergism; Electroencephalography; Hippocampus; Mal | 1990 |
Nifedipine poisoning in a child.
Topics: Blindness; Combined Modality Therapy; Drug Overdose; Emergencies; Female; Heart Block; Hemodynamics; | 1990 |
Protective effect of nifedipine on convulsive NEFA increase in CNS.
Topics: Animals; Bemegride; Fatty Acids, Nonesterified; Male; Nifedipine; Rats; Rats, Inbred Strains; Seizur | 1990 |
The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Phencyclidine and MK-801: a behavioral and neurochemical comparison of their interactions with dihydropyridine calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Convulsants; Dibenzocycloheptenes; Dizocilpine | 1989 |
Potentiation of cocaine toxicity with calcium channel blockers.
Topics: Animals; Cocaine; Diltiazem; Drug Synergism; Injections, Intraperitoneal; Male; Nifedipine; Rats; Ra | 1989 |