nifedipine has been researched along with Abnormalities, Drug-Induced in 4 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nifedipine was determined to be the more toxic and teratogenic than ritodrine, with a LC50 of 0." | 5.42 | Evaluating the Teratogenicity of Ritodrine and Nifedipine using a Frog Embryo Teratogenesis assay (FETAX). ( Akillioğlu, K; Binokay, US; Boğa Pekmezekmek, A; Kumcu, E; Özaykan, B; Seçilmiş, MA; Sertdemir, Y; Şimşek, E, 2015) |
| "In a recent study, the vasodilating drugs nifedipine, nitrendipine, felodipine, and hydralazine induced phalangeal defects in rabbits, when given on day 16 of pregnancy." | 3.68 | Histological and in vitro studies supporting decreased uteroplacental blood flow as explanation for digital defects after administration of vasodilators. ( Danielson, M; Danielsson, BR; Dencker, L; Regård, CG; Reiland, S; Rundqvist, E, 1990) |
| "Hyperphalangeal bones were found in postnatal rat pups of mothers treated with nifedipine during pregnancy." | 3.67 | Hyperphalangeal bones induced in rat pups by maternal treatment with nifedipine. ( Hasegawa, Y; Kanamori, S; Yoshida, T, 1988) |
| "Nifedipine was determined to be the more toxic and teratogenic than ritodrine, with a LC50 of 0." | 1.42 | Evaluating the Teratogenicity of Ritodrine and Nifedipine using a Frog Embryo Teratogenesis assay (FETAX). ( Akillioğlu, K; Binokay, US; Boğa Pekmezekmek, A; Kumcu, E; Özaykan, B; Seçilmiş, MA; Sertdemir, Y; Şimşek, E, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boğa Pekmezekmek, A | 1 |
| Binokay, US | 1 |
| Seçilmiş, MA | 1 |
| Kumcu, E | 1 |
| Şimşek, E | 1 |
| Akillioğlu, K | 1 |
| Sertdemir, Y | 1 |
| Özaykan, B | 1 |
| Danielsson, BR | 2 |
| Danielson, M | 2 |
| Rundqvist, E | 2 |
| Reiland, S | 2 |
| Dencker, L | 1 |
| Regård, CG | 1 |
| Yoshida, T | 1 |
| Kanamori, S | 1 |
| Hasegawa, Y | 1 |
4 other studies available for nifedipine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Evaluating the Teratogenicity of Ritodrine and Nifedipine using a Frog Embryo Teratogenesis assay (FETAX).
Topics: Abnormalities, Drug-Induced; Animals; Biological Assay; Dose-Response Relationship, Drug; Drug Inter | 2015 |
Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Blood Vessels; Female; Fetal Hypoxia; Gestational Age; Heart R | 1992 |
Histological and in vitro studies supporting decreased uteroplacental blood flow as explanation for digital defects after administration of vasodilators.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Extremities; Felodipine; Female; In Vitro Techni | 1990 |
Hyperphalangeal bones induced in rat pups by maternal treatment with nifedipine.
Topics: Abnormalities, Drug-Induced; Animals; Female; Forelimb; Gestational Age; Maternal-Fetal Exchange; Ni | 1988 |