Compounds > nicotine
Page last updated: 2024-08-26

nicotine and Disease Models, Animal

nicotine has been researched along with Disease Models, Animal in 713 studies

Research

Studies (713)

TimeframeStudies, this research(%)All Research%
pre-199016 (2.24)18.7374
1990's31 (4.35)18.2507
2000's246 (34.50)29.6817
2010's340 (47.69)24.3611
2020's80 (11.22)2.80

Authors

AuthorsStudies
Dahdouh, A; Damaj, MI; Dukat, M; Glennon, RA; Martin, BR; Siripurapu, U; Taroua, M1
Brieaddy, LE; Burgess, JP; Damaj, MI; Ivy Carroll, F; Lee, JR; Ma, W; Martin, BR; Navarro, HA; Yokota, Y1
Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Hong, JH; Kim, CI; Kim, SS; Kwon, HJ; Lim, MK; Oh, YT; Park, J; Park, JB; Park, S; Ryu, H; Yin, J1
Asth, L; de Barros, JLVM; de Miranda, AS; Machado, CA; Moreira, FA; Oliveira, BDS; Rosa, MLP; Teixeira, AL; Toscano, ECB1
Abreu-Villaça, Y; Couto, LA; Dutra-Tavares, AC; Filgueiras, CC; Maia, JG; Manhães, AC; Ribeiro-Carvalho, A; Semeão, KA1
Grace, AA; Sved, AF; Weeks, JJ1
Abburi, C; McDaid, J1
Clark, JD; Guo, TZ; Kingery, WS; Li, WW; Sahbaie, P; Shi, XY1
Bhide, PG; Biederman, J; Levenson, CW; Salazar, VC; Zafonte, R; Zhang, L1
Aotani, D; Guo, T; Hattori, R; Jinno, T; Kataoka, H; Koyama, H; Kuga, Y; Matsumura, S; Ogawa, K; Shimizu, Y; Takeda, K; Tanaka, T; Yagi, T1
Hayashi, S; Kadowaki, M; Kanauchi, Y; Lee, J; Yamamoto, T; Yoshida, M; Zhang, Y1
Avelar, AJ; Cooper, SY; Henderson, BJ; Richardson, MR; Wright, SK; Wright, TD1
Certilina, A; Charalambous, C; Khryakova, A; Lapka, M; Šlamberová, R; Sustkova-Fiserova, M1
Avila, Y; Barazzone-Argiroffo, C; Blaskovic, S; Donati, Y; Ruchonnet-Metrailler, I; Schittny, D; Schittny, JC; Schlepütz, CM1
Kantak, KM1
Carvallo, C; Contreras, D; Godoy, F; Morales, B; Piña, R; Rozas, C; Ugarte, G; Zeise, M1
Buck, JM; Ehringer, MA; Evans, LM; Funkhouser, SA; Mize, TJ; Stitzel, JA1
Bridge, MF; Fannin, RD; Gerrish, KE; Letsinger, AC; Mahapatra, D; Sills, RC; Ward, JM; Yakel, JL1
Cao, H; Chen, H; Li, B; Mu, M; Tao, X; Wang, W; Zhao, Y; Zou, Y1
Auberson, M; Bornand, D; Dulize, R; Guedj, E; Hoeng, J; Lo Sasso, G; Nef, P; Peitsch, MC; Peric, D; Sewer, A; Sierro, N; Tabruyn, SP; Talikka, M; Verhaeghe, C1
Abreu-Villaça, Y; Dutra-Tavares, AC; Filgueiras, CC; Manhães, AC; Ribeiro-Carvalho, A; Rodríguez-Vega, A; Semeão, KA; Souza, TP1
Collares, MVM; Dullius, D; Durli, ICLO; Hiraiwa, E; Lima, EOC; Martins, JMP; Oliveira, FDS; Sampaio, PMR; Serrano, T; Teixeira, GR1
Baghaei, N; Campen, MJ; Chang, CY; Corry, DB; Gilbert, BE; Gu, BH; Hong, MJ; Kheradmand, F; Landers, CT; Levental, I; Madison, MC; Porter, P; Putluri, N; Salas, R; Song, LZ; Tung, HY; You, R1
Gao, T; Lan, Q; Mao, Y; Sheng, Z; Wang, D; Zhao, Y1
Barbosa, RI; das Neves, LMS; de Jesus Guirro, RR; de Oliveira Guirro, EC; de Souza, AK; de Souza, TR; Garcia, SB1
Aliyeva, M; Ather, JL; Casey, DT; Chapman, DG; Daphtary, N; Irvin, CG; Janssen-Heininger, YMW; Lahue, KG; van der Velden, JL1
DeBaker, MC; Lee, AM; Moen, JK; Robinson, JM; Wickman, K1
Bhide, PG; Jones, SK; Kalluri, A; Martin, MM; McCarthy, DM; Schatschneider, C; Trupiano, MX1
Anderson, MS; Buczynski, MW; Faunce, CL; Gnatowski, ER; Gregus, AM; Miliano, C; Murdaugh, LB; Reyes, MM; Scott, ER1
Adeluyi, A; Chan, SSL; Cole, RD; Davis, SW; Fisher, ML; Freeman, LR; Galloway, A; Guerin, L; Ortinski, PI; Turner, JR; Wyatt, MD1
Belluzzi, JD; Cano, M; Cross, SJ; Leslie, FM; Reynaga, DD; Zaveri, NT1
Abtahi Froushani, SM; Golbahari, S1
Candiotti, KA; Gitlin, M; Rodriguez-Blanco, YF; Sevilla, A; Su, C; Weller, R; Wu, J; Yang, J; Zhang, Y; Zheng, C1
Gao, W; Sun, X; Wan, Y; Wu, W; Xue, R; Zhang, X1
Laviolette, SR1
Kim, B; Kim, JW; Lim, CW; Park, S; Qi, J; Zhao, J; Zhou, Z1
Alarabi, AB; Alshbool, FZ; Hernandez, KR; Karim, ZA; Khasawneh, FT; Lozano, PA; Ramirez, JEM; Rivera, JO1
Cano, M; Gad, M; Green, KN; Leslie, FM; Linker, KE; Tawadrous, P; Wood, MA1
Bertoncello, KT; Canzian, J; Fontana, BD; Franscescon, F; Gerlai, R; Mezzomo, NJ; Müller, TE; Parker, MO; Rosemberg, DB; Stefanello, FV1
Nazarian, A; O'Dell, LE; Richardson, JR1
Liu, X; Qin, Z; Sun, Y; Wan, JJ; Wang, PY; Wei, J; Zhang, Y1
Li, P; Li, X; Xu, J1
Barbosa, RI; Cardoso, RB; de Oliveira Guirro, EC; Kuriki, HU; Marcolino, AM; Rodrigues, M1
Balachandran, RC; Eubig, PA; Hatcher, KM; Mahoney, MM; Molina, LM; Sieg, ML; Sullivan, EK1
Chen, Y; Jia, MZ; Ning, ZP; Qi, YF; Ren, JL; Tang, CS; Wu, N; Yu, YR; Zhang, LS; Zhang, YR1
Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; Lv, YQ; Lyu, HD; Lyu, J; Ma, C; Ma, G; Ma, L; Ma, Q; Ma, X; Ma, Y; Macha, SJ; MacLean, E; Mahalapbutr, P; Maina, T; Malfait, F; Malfertheiner, MV; Malzert-Fréon, A; Mansouri, E; Mao, C; Marcellin, E; Marchiori, PER; Marcotte, DJ; Maréchal, A; Maric, N; Maris, JM; Maron, L; Marti, CN; Martínez-Milla, J; Mateo, J; Mather, K; Mathison, CJN; Matthay, MA; Maxwell, CL; Mazier, D; Mazumder, D; Mazurkiewicz, M; Mazzucchelli, TG; McAuley, DF; Mccoy, K; McVicar, DW; Mebel, AM; Mech, A; Meester, EJ; Meiselbach, H; Melero, I; Ménard, G; Meng, X; Mengya, Y; Merle, G; Meunier, B; Mfarrej, B; Mi, K; Migueliz, I; Mikuška, P; Miladi, K; Miletich, R; Millar, JE; Mills, MR; Milne, R; Minute, L; Misiak, M; Mo, F; Modi, A; Mok, F; Molina, C; Mollen, CJ; Molteni, V; Montalto, M; Montet, D; Monti, MC; Moor, MB; Moravec, P; Morsiani, C; Murillo, E; Murugan, P; Muslem, R; Myers, RK; N'guessan, FK; Nabil, H; Nadal, J; Nadeem, M; Nafady, MM; Nafie, MS; Nair, HP; Nakano, R; Nance, J; Naren, N; Neil, CJ; Nelson, J; Nery, FC; Netsch, C; Nguyen, TH; Ni, L; Ni, YX; Nie, W; Nielsen, LK; Nigam, K; Nikolayev, AA; Nishiyama, M; Niu, LL; Niu, PP; Nock, BA; Noer, PR; Noll, G; Noll, S; Norenberg, JP; Nowicka, J; Nutho, B; O'Connor, M; Obonyo, NG; Ochiai, T; Ochoa, MC; Oh, BL; Oh, S; Olczak, J; Olivares, X; Ommurugan, B; Oosthuizen, MC; Operario, D; Orešič, M; Oshima, K; Otano, I; Ou, Y; Owen, TW; Oxvig, C; Pacey, V; Pai, M; Paik, H; Paiva, R; Palmieri, EM; Palpant, N; Pan, L; Pan, Q; Panahi, S; Pang, B; Pang, ZC; Pannecouque, C; Paris, L; Park, D; Park, DJ; Park, E; Park, EC; Park, IH; Park, JH; Park, JI; Park, S; Passmore, MR; Pattaranggoon, NC; Paun, M; Pedersen, S; Pedron, J; Peng, M; Peng, X; Penzhorn, BL; Pérez-Camargo, D; Perez-Maldonado, R; Pérez-Vicente, C; Pham, TD; Pickering, L; Pickersgill, NA; Pinault, E; Pinotsis, N; Plan, M; Pocino, K; Poh, CL; Pons, EDC; Popoff, MR; Porri, D; Pourmand, A; Pratviel, G; Prudente, DO; Qi, H; Qi, N; Qian, LY; Qiao, L; Qiao, Q; Qin, QP; Qiu, N; Qiu, SW; Qu, F; Quan, M; 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Boretsky, A; Godley, B; Gupta, P; Kulp, GA; Motamedi, M; Tilton, RG; Tirgan, N; Wiraszka, TA1
Bargas, J; Boronat-García, A; Drucker-Colín, R; García-Montes, JR; Guerra-Crespo, M; López-Colomé, AM1
Aziz, Q; Broad, J; Bulmer, DC; Dukes, GE; Javid, FA; Sanger, GJ1
Alabalik, U; Azboy, I; Bulut, M; Demirtas, A; Ilgezdi, S; Ucar, BY1
Hayes, MR; Kimmey, BA; Rupprecht, LE; Schmidt, HD1
Abdel, AY; Baynes, B; George, O; Gilpin, NW; Weil, MT; Whitaker, AM1
Poole, SD; Sandberg, KL; Sundell, HW1
Chang, JR; Chen, WJ; Qi, YF; Sui, YB; Tang, CS; Yin, XH; Yu, YR; Zhang, BH; Zhao, L1
Bonfante-Cabarcas, R; Durand Mena, M; Ferrer Mancini, L; Fonseca Zambrano, R; Jiménez Hernández, E; López Hincapié, E; Rodríguez-Bonfante, C1
Bordia, T; McIntosh, JM; Quik, M1
Iwahashi, M; Matsuzaki, H; Tokuhashi, Y; Uematsu, Y; Wakabayashi, K1
Liu, Y; Luo, P; Zuo, P1
Hall, W1
Shafait, S; Shoaib, M; Sidhpura, N1
Andrews, PL; Paton, JF; Smith, JE1
Heberlein, U; Wolf, FW1
Bayna, E; Dalle Molle, E; Lew, WY; Suzuki, J1
Cooke, JP; Heeschen, C; Weis, M1
Pauly, JR; Scheff, SW; Verbois, SL1
Danysz, W; Löscher, W; Parsons, CG; Potschka, H; Wlaź, P1
Edwards, JE; File, SE; Genn, RF; Tucci, S1
Levin, ED; Montoya, D; Rezvani, AH; Rose, JE; Swartzwelder, HS1
Elliott, BM; Faraday, MM; Grunberg, NE1
Cloak, CC; Poland, RE; Ross, MG; Smith, LM; Torday, J1
Camí, J; Farré, M1
Damaj, MI; Kao, W; Martin, BR1
Girlanda, E; Heidbreder, CA; Lennon, M; Mugnaini, M; Sartori, I; Varnier, G; Wildish, GA; Zanetti, L; Zocchi, A1
Cho, CH; Liu, ES; Luo, JC; Shin, VY; Wu, WK; Ye, YN1
Maeda, J; Semba, J; Suhara, T; Wakuta, M1
Brewer, PD; Chuang, AH; Cuenin, MF; Henemyre, CL; Hokett, SD; Parker, MH; Peacock, ME; Scales, DK1
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Cryan, JF; Gasparini, F; Markou, A; van Heeke, G1
Cousins, SW; Espinosa-Heidmann, DG; Hernandez, EP; Marin-Castano, ME; Pereira-Simon, S; Suñer, IJ1
Sarioğlu, Y; Tugay, M; Utkan, T; Utkan, Z; Yildiz, F1
Suszkiw, JB; Zhou, M1
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Butt, CM; Collins, AC; Hutton, SR; King, NM; Stitzel, JA1
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Bruijnzeel, AW; Markou, A1
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Goldberg, SR; Le Foll, B1
Bainton, RJ; DeSalvo, M; Gaul, U; Heberlein, U; Schwabe, T; Tsai, LT1
Bardo, MT; Crooks, PA; Dwoskin, LP; Neugebauer, NM; Zhang, Z1
Chan, L; Ko, KW; Lau, PP; Li, L; Merched, AJ; Zhang, AL1
Berlin, I; Heilbronner, C1
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Frye, GD; Hsiao, SH; Huang, LZ; Trzeciakowski, J; Winzer-Serhan, UH1
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Guo, L; Qi, YF1
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Siu, EC; Tyndale, RF; Wildenauer, DB1
Bevins, RA; Palmatier, MI; Wilkinson, JL1
Hassel, B1
Allan, AM; Barsness, B; Martenson, T; Paz, R; Tanner, D1
Jonkman, S; Markou, A1
Matsuzaki, H; Nemoto, Y; Nishimura, T; Oda, H; Okawa, A; Tokuhasi, Y; Uematu, Y1
Leslie, FM; Loughlin, SE; Park, MK1
Fryxell, KJ; Polesskaya, OO; Smith, RF1
Chen, Y; Leslie, FM; Liang, K; Metherate, R; Poytress, BS; Weinberger, NM1
Jiaquan, L; Qi, B; Ruixing, Y; Tangwei, L1
Cattaneo, A; Cherubini, E; Rosato-Siri, M1
De Witte, P; Dravolina, O; Lallemand, F; Ward, RJ1
Fanous, AM; Machaalani, R; Waters, KA1
Aleisa, AM; Alkadhi, KA; Alzoubi, KH2
Aleisa, AM; Alkadhi, KA; Alzoubi, KH; Gerges, NZ1
Josiah, DT; Vincler, MA1
Shoaib, M1
Dar, MS; Smith, AD1
Galatz, LM; Havlioglu, N; Rothermich, SY; Silva, MJ; Thomopoulos, S; Zaegel, MA1
Casati, MZ; Nociti, FH; Pimentel, SP; Saldanha, JB; Sallum, AW; Sallum, EA1
Cagnon, VH; Fávaro, WJ1
Blennerhassett, P; Collins, SM; Ghia, JE; Kumar-Ondiveeran, H; Verdu, EF1
Bencan, Z; Cerutti, DT; Levin, ED1
Aimiuwu, O; Anghel, A; Brown, MC; Friedman, TC; Lutfy, K; Nerio, N; Tran, B1
Clark, ML; Gideon, KM; Harbo, SJ; Johnson, RE; Lee, KM; Renne, RA1
Boulter, J; Glykys, J; Klaassen, A; Labarca, C; Maguire, J; Mody, I1
Di Monte, DA; Khwaja, M; McCormack, A; McIntosh, JM; Quik, M1
Davis, JA; Gould, TJ1
Chan, SW; Li, P; Lin, G; Rudd, JA1
Hughes, JR1
Giros, B; Martres, MP; McIntosh, JM; Nosten-Bertrand, M; Weiss, S1
Chan, CC; Leung, FW1
Elberger, AJ; Matta, SG1
O'Neill, M; Perez, XA; Quik, M1
Bienkowski, P; Korkosz, A; Kostowski, W; Plaznik, A; Taracha, E; Zatorski, P1
Ferrari, MF; Fior-Chadi, DR1
Albert, TJ; Biswas, D; Gillon, TJ; Grauer, JN; Lawrence, JP; Rosenberger, P; Spock, CR; Troiano, N; Waked, W; White, AP1
Chen, H; Fu, Y; Sharp, BM1
Harris, AC; Lesage, MG; Pentel, PR1
Atkinson, J; da Silva, RF; Gaillard, V; Jeanrenaud, X; Jegger, D; Lartaud, I; Nasratullah, M; Segers, P; Stergiopulos, N; Tevaearai, H; von Segesser, LK1
Shoaib, M; Wing, VC1
Gass, JT; Olive, MF1
Bermudez-Silva, FJ; Gallego, A; Lamota, L; Llorente, R; Marco, EM; Rodríguez de Fonseca, F; Viveros, MP1
Biala, G; Kruk, M1
Lamota, L; Llorente, R; Marco, EM; Viveros, MP1
Asahara, T; Eguchi, M; Iwaguro, H; Masuda, H; Sugimoto, A; Tanabe, T1
Chen, M; Feng, YH; Liao, ZX; Pan, XL; Wang, H; Wang, T1
Berkovic, SF; Cahir, E; Chen, F; Cohen, BN; Davies, PJ; Drago, J; Fonck, C; Gantois, I; Grady, SR; Horne, MK; Labarca, C; Lawrence, A; Lester, HA; Marks, MJ; McClure-Begley, T; McIntosh, JM; Murphy, M; Petrou, S; Teper, Y; Waddington, J; Whyte, D1
De Vries, TJ; de Vries, W; Diergaarde, L; Hogenboom, F; Pattij, T; Poortvliet, I; Schoffelmeer, AN1
Mardekian, SK; Rauhut, AS; Tanenbaum, JB; Zentner, IJ1
Becker, JB; Hu, M1
Bennink, R; Boeckxstaens, GE; Cash, JL; de Jonge, WJ; Greaves, DR; Larosa, GJ; Snoek, SA; The, FO; van den Wijngaard, RM1
Bonaz, B1
Chan, MH; Chen, HH; Chien, TH; Tang, YC1
Winzer-Serhan, UH1
Akahoshi, N; Himi, T; Ishii, I; Ishizaki, Y; Murashima, YL1
Geyer, MA; Jonkman, S; Markou, A; Risbrough, VB1
Caggiula, AR; Donny, EC; Liu, X; Palmatier, MI; Sved, AF1
Chae, Y; Hahm, DH; Han, JH; Lee, H; Lee, HS; Park, HJ; Shim, I; Yeom, M1
Eriksson, P; Fredriksson, A; Johansson, N1
Bierhaus, A; Bode, K; Brueckmann, M; Dalpke, AH; Eisenbach, C; Encke, J; Hofer, S; Krammer, PH; Lukic, IK; Martin, E; Mautner, S; Nawroth, PP; Schneider, L; Stremmel, W; Weigand, MA; Wente, MN; Werner, J1
Tizabi, Y1
Bruin, JE; Gerstein, HC; Holloway, AC; Morrison, KM1
Fratta, W; González-Cuevas, G; López-Moreno, JA; Navarro, M; Rodríguez de Fonseca, F; Scherma, M1
Borowitz, JL; Isom, GE1
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Campochiaro, PA; Cooke, JP; Kengatharan, M; Khu, NH; Kiuchi, K; Lima e Silva, R; Matsuoka, M; Ueno, S; Verghese, M; Wu, JC; Yokoi, K1
Chida, Y; Hiramoto, T; Kubo, C; Sonoda, J; Sudo, N; Yoshihara, K1
Hou, HY; Wang, BR; Wang, YS; Xu, JF1
Klus, H; Müller, L; Thielen, A1
Martin, JC1
Benson, DM; Ksir, C1
Singer, G; Wallace, M1
Khodzhagel'diev, T1
Ikadai, H; Imamichi, T; Nakajyo, S; Sasaki, Y; Shimizu, K; Urakawa, N1
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Fasanmade, AA; Oyebola, DD1
Alada, AR; Oyebola, DD1
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Chambers, RA; Levin, ED; McEvoy, JP; Moore, J1
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Levin, ED; Newhouse, PA; Potter, A1
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Pepi, M1
Chatterjee, K; Chou, TM; Deedwania, PC; Glantz, SA; Hutchison, SJ; Parmley, WW; Sudhir, K; Sun, YP; Zhu, BQ1
Stephenson, J1
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Armstrong, D; Beaudet, AL; De Biasi, M; Gelber, S; Lewis, RA; Orr-Urtreger, A; Ou, CN; Patrick, J; Role, L; Xu, W1
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Levin, ED; Rezvani, AH1
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Ahtee, L; Gäddnäs, H; Pietilä, K1
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Silverman, AP1

Reviews

67 review(s) available for nicotine and Disease Models, Animal

ArticleYear
The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions.
    International journal of molecular sciences, 2022, Jan-11, Volume: 23, Issue:2

    Topics: Animals; Biomarkers; Central Nervous System Stimulants; Clinical Studies as Topic; Disease Models, Animal; Disease Susceptibility; Genetic Predisposition to Disease; Ghrelin; Humans; Nicotine; Receptors, Ghrelin; Reinforcement, Psychology; Signal Transduction; Substance-Related Disorders; Tobacco Use

2022
Rodent models of attention-deficit hyperactivity disorder: An updated framework for model validation and therapeutic drug discovery.
    Pharmacology, biochemistry, and behavior, 2022, Volume: 216

    Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Drug Discovery; Female; Humans; Mice; Mice, Knockout; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred SHR; Receptors, G-Protein-Coupled; Receptors, Peptide; Rodentia; Substance-Related Disorders

2022
Modeling drug exposure in rodents using e-cigarettes and other electronic nicotine delivery systems.
    Journal of neuroscience methods, 2020, 01-15, Volume: 330

    Topics: Animals; Central Nervous System Stimulants; Disease Models, Animal; Electronic Nicotine Delivery Systems; Nicotine; Peripheral Nervous System Agents; Rats; Rodentia; Vaping

2020
Exploring the impact of adolescent exposure to cannabinoids and nicotine on psychiatric risk: insights from translational animal models.
    Psychological medicine, 2021, Volume: 51, Issue:6

    Topics: Adolescent; Animals; Brain; Cannabinoids; Disease Models, Animal; Drug Synergism; Humans; Mental Disorders; Nicotine; Risk Factors; Smoking

2021
Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models.
    Progress in neuro-psychopharmacology & biological psychiatry, 2020, 06-08, Volume: 100

    Topics: Analgesics, Opioid; Animals; Brain; Cannabinoids; Disease Models, Animal; Ethanol; Humans; Nicotine; Substance-Related Disorders; Zebrafish

2020
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus

2016
Nicotine in Senescence and Atherosclerosis.
    Cells, 2020, 04-22, Volume: 9, Issue:4

    Topics: Animals; Atherosclerosis; Cardiovascular System; Cellular Senescence; Disease Models, Animal; Humans; Nicotine; Tobacco Use

2020
Rodent models for nicotine withdrawal.
    Journal of psychopharmacology (Oxford, England), 2021, Volume: 35, Issue:10

    Topics: Animals; Disease Models, Animal; Electronic Nicotine Delivery Systems; Humans; Mice; Nicotine; Rats; Sex Factors; Smoking Cessation; Smoking Cessation Agents; Substance Withdrawal Syndrome; Tobacco Use Disorder

2021
Unconventional anxiety pharmacology in zebrafish: Drugs beyond traditional anxiogenic and anxiolytic spectra.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 207

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Disease Models, Animal; Humans; Lysergic Acid Diethylamide; Motor Activity; Naloxone; Naltrexone; Nicotine; Zebrafish

2021
Toxicological and analytical assessment of e-cigarette refill components on airway epithelia.
    Science progress, 2016, 12-01, Volume: 99, Issue:4

    Topics: Animals; Bronchi; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Electronic Nicotine Delivery Systems; Epithelium; Flavoring Agents; Glycerol; Humans; Inhibitory Concentration 50; Liver; Lung; Metals; Mice; Nicotine; Propylene Glycol; Smoking; United Kingdom

2016
Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou.
    Biological psychiatry, 2018, 06-01, Volume: 83, Issue:11

    Topics: Animals; Behavior, Addictive; Brain; Disease Models, Animal; Drug Discovery; Drug-Seeking Behavior; Humans; Indoles; Nicotine; Oxadiazoles; Randomized Controlled Trials as Topic; Receptors, Metabotropic Glutamate; Self Administration

2018
Influence of nicotine on orthodontic tooth movement: A systematic review of experimental studies in rats.
    Archives of oral biology, 2018, Volume: 93

    Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Nicotine; Osteoclasts; Rats; Root Resorption; Tooth Movement Techniques

2018
Molecules and circuits involved in nicotine addiction: The many faces of smoking.
    Neuropharmacology, 2014, Volume: 76 Pt B

    Topics: Animals; Appetite; Brain; Disease Models, Animal; Humans; Mood Disorders; Nicotine; Receptors, Nicotinic; Smoking Cessation; Tobacco Use Disorder

2014
Nicotinic cholinergic signaling in adipose tissue and pancreatic islets biology: revisited function and therapeutic perspectives.
    Archivum immunologiae et therapiae experimentalis, 2014, Volume: 62, Issue:2

    Topics: Acetylcholine; Adipose Tissue; Animals; Diabetes Mellitus; Disease Models, Animal; Humans; Islets of Langerhans; Mice; Mice, Knockout; Molecular Targeted Therapy; Nicotine; Obesity; Receptors, Cholinergic; Signal Transduction

2014
Whole tobacco smoke extracts to model tobacco dependence in animals.
    Neuroscience and biobehavioral reviews, 2014, Volume: 47

    Topics: Animals; Disease Models, Animal; Nicotiana; Nicotine; Self Administration; Smoke; Tobacco Use Disorder

2014
The Gateway Hypothesis of substance abuse: developmental, biological and societal perspectives.
    Acta paediatrica (Oslo, Norway : 1992), 2015, Volume: 104, Issue:2

    Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Disease Models, Animal; Disease Progression; Dopamine Uptake Inhibitors; Ganglionic Stimulants; Humans; Nicotine; Substance-Related Disorders

2015
New mechanisms and perspectives in nicotine withdrawal.
    Neuropharmacology, 2015, Volume: 96, Issue:Pt B

    Topics: Animals; Brain; Disease Models, Animal; Humans; Neurons; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Signal Transduction; Substance Withdrawal Syndrome; Tobacco Use Disorder

2015
Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment.
    Neuropharmacology, 2015, Volume: 96, Issue:Pt B

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Humans; Mice, Transgenic; Neurons; Nicotine; Nicotinic Agonists; Receptors, Muscarinic; Receptors, Nicotinic

2015
Effects of drugs of abuse on the central neuropeptide Y system.
    Addiction biology, 2016, Volume: 21, Issue:4

    Topics: Amphetamines; Animals; Brain; Cocaine; Disease Models, Animal; Ethanol; Mice; Neuropeptide Y; Nicotine; Opiate Alkaloids; Rats; Receptors, Neuropeptide Y

2016
How can we Improve on Modeling Nicotine Addiction to Develop Better Smoking Cessation Treatments?
    International review of neurobiology, 2016, Volume: 126

    Topics: Animals; Disease Models, Animal; Humans; Nicotine; Nicotinic Agonists; Reinforcement, Psychology; Self Administration; Smoking Cessation; Tobacco Use Disorder

2016
Pulmonary Effects of Maternal Smoking on the Fetus and Child: Effects on Lung Development, Respiratory Morbidities, and Life Long Lung Health.
    Paediatric respiratory reviews, 2017, Volume: 21

    Topics: Animals; Antioxidants; Ascorbic Acid; Asthma; Child; Disease Models, Animal; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Lung; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Respiratory Tract Diseases; Smoking; Tobacco Smoke Pollution

2017
Prenatal nicotine exposure and development of nicotinic and fast amino acid-mediated neurotransmission in the control of breathing.
    Respiratory physiology & neurobiology, 2008, Dec-10, Volume: 164, Issue:1-2

    Topics: Animals; Disease Models, Animal; Female; Humans; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Respiration Disorders; Synaptic Transmission

2008
[Evaluation of antipsychotic and relative drugs using disruption of prepulse inhibition as an animal model for schizophrenia].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2008, Volume: 28, Issue:3

    Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Humans; Mice; Nicotine; Physical Stimulation; Reflex, Startle; Schizophrenia; Schizophrenic Psychology

2008
A psychobiological framework of the substrates that mediate nicotine use during adolescence.
    Neuropharmacology, 2009, Volume: 56 Suppl 1

    Topics: Adolescent; Age Factors; Animals; Brain Chemistry; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Humans; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Tobacco Use Disorder; Ventral Tegmental Area

2009
Rodent models of nicotine reward: what do they tell us about tobacco abuse in humans?
    Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:4

    Topics: Animals; Disease Models, Animal; Humans; Mice; Nicotine; Nicotinic Agonists; Rats; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder

2009
[Nicotinic acetylcholine receptors are possible therapeutic targets for schizophrenia].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2009, Volume: 129, Issue:2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antiemetics; Disease Models, Animal; Dopamine; Gait Disorders, Neurologic; Humans; Indoles; Neural Inhibition; Nicotine; Rats; Receptors, Nicotinic; Schizophrenia; Serotonin Antagonists; Stereotyped Behavior; Tropisetron

2009
Rodent models of nicotine withdrawal syndrome.
    Handbook of experimental pharmacology, 2009, Issue:192

    Topics: Animals; Disease Models, Animal; Gene Expression; Mice; Nicotine; Nicotinic Agonists; Rats; Severity of Illness Index; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Validation Studies as Topic

2009
An animal model of social instability stress in adolescence and risk for drugs of abuse.
    Physiology & behavior, 2010, Feb-09, Volume: 99, Issue:2

    Topics: Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Female; Hypothalamo-Hypophyseal System; Male; Nicotine; Pituitary-Adrenal System; Rats; Social Behavior; Stress, Psychological; Substance-Related Disorders

2010
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice.
    Nature reviews. Neuroscience, 2010, Volume: 11, Issue:6

    Topics: Animals; Behavior, Animal; Central Nervous System; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Transgenic; Models, Biological; Models, Molecular; Neural Pathways; Nicotine; Protein Subunits; Receptors, Nicotinic; Reward; Tobacco Use Disorder

2010
Zebrafish for the study of the biological effects of nicotine.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2011, Volume: 13, Issue:5

    Topics: Animals; Anxiety; Behavior, Addictive; Disease Models, Animal; Humans; Learning; Models, Animal; Nicotine; Zebrafish

2011
Mechanistic insights into nicotine withdrawal.
    Biochemical pharmacology, 2011, Oct-15, Volume: 82, Issue:8

    Topics: Animals; Brain; Disease Models, Animal; Dopamine; Humans; Nicotine; Receptors, Nicotinic; Reinforcement, Psychology; Smoking Cessation; Substance Withdrawal Syndrome

2011
The emerging role of smoking in the development of pancreatitis.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2011, Volume: 11, Issue:5

    Topics: Animals; Disease Models, Animal; Disease Progression; Female; Humans; Male; Nicotine; Pancreas; Pancreatitis; Pancreatitis, Chronic; Risk Factors; Smoking; Tobacco Smoke Pollution

2011
The Yin and Yang of non-neuronal α7-nicotinic receptors in inflammation and autoimmunity.
    Current drug targets, 2012, Volume: 13, Issue:5

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoimmune Diseases; Disease Models, Animal; Drug Delivery Systems; Humans; Inflammation; Ligands; Nicotine; Nicotinic Agonists; Receptors, Nicotinic

2012
Drosophila melanogaster as a model to study drug addiction.
    Human genetics, 2012, Volume: 131, Issue:6

    Topics: Amphetamines; Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Drosophila melanogaster; Ethanol; Neural Pathways; Nicotine; Substance-Related Disorders; Synaptic Transmission

2012
Nicotine as a potential neuroprotective agent for Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2012, Volume: 27, Issue:8

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Humans; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Parkinson Disease; Parkinson Disease, Secondary; Receptors, Nicotinic; Signal Transduction; Smoking; Substantia Nigra

2012
Schizophrenia and substance abuse comorbidity: nicotine addiction and the neonatal quinpirole model.
    Developmental neuroscience, 2012, Volume: 34, Issue:2-3

    Topics: Animals; Behavior, Addictive; Disease Models, Animal; Nicotine; Quinpirole; Schizophrenia; Tobacco Use Disorder

2012
Impact of tobacco regulation on animal research: new perspectives and opportunities.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012, Volume: 14, Issue:11

    Topics: Animal Experimentation; Animals; Comorbidity; Disease Models, Animal; Dose-Response Relationship, Drug; Government Regulation; Humans; Nicotiana; Nicotine; Rodentia; Schizophrenia; Self Administration; Smoking Cessation; Tobacco Industry; Tobacco Products; Tobacco Use Disorder; United States

2012
The prospects for immunotherapy in smoking cessation.
    Lancet (London, England), 2002, Oct-05, Volume: 360, Issue:9339

    Topics: Adolescent; Adult; Antibodies; Blood-Brain Barrier; Disease Models, Animal; Health Education; Humans; Needs Assessment; Nicotine; Patient Compliance; Recurrence; Smoking; Smoking Cessation; Smoking Prevention; Treatment Outcome; Vaccination

2002
Invertebrate models of drug abuse.
    Journal of neurobiology, 2003, Volume: 54, Issue:1

    Topics: Alcoholic Intoxication; Animals; Behavior, Animal; Caenorhabditis elegans; Cocaine; Disease Models, Animal; Dopamine; Drosophila melanogaster; Drug Tolerance; Ethanol; Learning; Memory; Nicotine; Substance-Related Disorders

2003
Drug addiction.
    The New England journal of medicine, 2003, Sep-04, Volume: 349, Issue:10

    Topics: Animals; Cannabinoids; Cocaine; Disease Models, Animal; Dopamine; Ethanol; Humans; Narcotics; Nicotine; Recurrence; Reinforcement, Psychology; Substance Withdrawal Syndrome; Substance-Related Disorders

2003
Intergenerational transmission of tobacco use and dependence: a transdisciplinary perspective.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003, Volume: 5 Suppl 1

    Topics: Adult; Disease Models, Animal; Environment; Female; Ganglionic Stimulants; Genetic Predisposition to Disease; Humans; Interprofessional Relations; Nicotine; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Research; Risk Factors; Tobacco Use Disorder

2003
Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion.
    Drug discovery today, 2003, Nov-15, Volume: 8, Issue:22

    Topics: Animals; Bupropion; Disease Models, Animal; Extinction, Psychological; Humans; Nicotine; Reinforcement Schedule; Smoking Cessation; Tobacco Use Disorder

2003
Windows of vulnerability to psychopathology and therapeutic strategy in the adolescent rodent model.
    Behavioural pharmacology, 2004, Volume: 15, Issue:5-6

    Topics: Adolescent; Adolescent Behavior; Animals; Attention Deficit Disorder with Hyperactivity; Cannabinoids; Disease Models, Animal; Ganglionic Stimulants; Humans; Nicotine; Rats; Rats, Inbred SHR; Risk-Taking; Substance-Related Disorders

2004
Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function.
    Frontiers in bioscience : a journal and virtual library, 2004, Sep-01, Volume: 9

    Topics: Acetylcholine; Animals; Antigen Presentation; Antigens; Calcium; CD3 Complex; Cell Membrane; Choline O-Acetyltransferase; Disease Models, Animal; Endothelium, Vascular; Humans; Immune System; Lymphocyte Activation; Lymphocytes; Membrane Transport Proteins; Neurons; Nicotine; Nitric Oxide; Phytohemagglutinins; Proto-Oncogene Proteins c-fos; Receptors, Cholinergic; RNA, Messenger; Signal Transduction; Thymus Gland; Up-Regulation

2004
Nicotinic receptor modulation for neuroprotection and enhancement of functional recovery following brain injury or disease.
    Annals of the New York Academy of Sciences, 2004, Volume: 1035

    Topics: Animals; Brain Diseases; Disease Models, Animal; Drug Administration Schedule; Humans; Mice; Neuroprotective Agents; Nicotine; Receptors, Nicotinic; Recovery of Function

2004
Cue reactivity in nicotine and tobacco dependence: a "multiple-action" model of nicotine as a primary reinforcement and as an enhancer of the effects of smoking-associated stimuli.
    Brain research. Brain research reviews, 2005, Volume: 48, Issue:1

    Topics: Animals; Brain; Cues; Disease Models, Animal; Humans; Models, Neurological; Neural Pathways; Nicotine; Reinforcement, Psychology; Tobacco Use Disorder

2005
Novelty reward as a measure of anhedonia.
    Neuroscience and biobehavioral reviews, 2005, Volume: 29, Issue:4-5

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Depression; Disease Models, Animal; Exploratory Behavior; Humans; Nicotine; Nicotinic Agonists; Reward; Substance Withdrawal Syndrome; Weights and Measures

2005
Pharmacotherapy and pharmacogenetics of nicotine dependence.
    The American journal of psychiatry, 2005, Volume: 162, Issue:8

    Topics: Administration, Cutaneous; Administration, Intranasal; Animals; Animals, Genetically Modified; Bupropion; Clinical Trials as Topic; Disease Models, Animal; Drug Design; Genetic Predisposition to Disease; Genotype; Humans; Nicotine; Pharmacogenetics; Phenotype; Smoking Cessation; Tobacco Use Disorder; United States

2005
Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Animals; Association Learning; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Motivation; Nicotine; Rats; Reinforcement, Psychology; Self Administration; Smoking; Tobacco Use Disorder

2006
Endocannabinoids and drug dependence.
    Current drug targets. CNS and neurological disorders, 2005, Volume: 4, Issue:6

    Topics: Alcoholism; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Disease Models, Animal; Dopamine; Endocannabinoids; Humans; Narcotics; Nicotine; Substance-Related Disorders

2005
Effects of abstinence from tobacco: etiology, animal models, epidemiology, and significance: a subjective review.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2007, Volume: 9, Issue:3

    Topics: Animals; Disease Models, Animal; Humans; Mental Disorders; Nicotine; Randomized Controlled Trials as Topic; Research Design; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder

2007
Nicotine neuroprotection against nigrostriatal damage: importance of the animal model.
    Trends in pharmacological sciences, 2007, Volume: 28, Issue:5

    Topics: Animals; Disease Models, Animal; Dopamine; Humans; Mice; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Parkinson Disease; Primates; Rats; Substantia Nigra

2007
Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction.
    Biochemical pharmacology, 2008, Jan-01, Volume: 75, Issue:1

    Topics: Animals; Disease Models, Animal; Genetic Linkage; Humans; Mice; Nicotine; Polymorphism, Single Nucleotide; Protein Subunits; Receptors, Nicotinic; Tobacco Use Disorder

2008
Glutamatergic substrates of drug addiction and alcoholism.
    Biochemical pharmacology, 2008, Jan-01, Volume: 75, Issue:1

    Topics: Alcoholism; Amphetamines; Animals; Cannabinoids; Cocaine; Disease Models, Animal; Extinction, Psychological; Glutamic Acid; Humans; Narcotics; Neuronal Plasticity; Nicotine; Substance-Related Disorders; Synapses; Synaptic Transmission

2008
The role of the hippocampus in mediating emotional responses to nicotine and cannabinoids: a possible neural substrate for functional interactions.
    Behavioural pharmacology, 2007, Volume: 18, Issue:5-6

    Topics: Animals; Anxiety; Behavior, Animal; Cannabinoid Receptor Modulators; Cannabinoids; Conditioning, Psychological; Disease Models, Animal; Emotions; Ganglionic Stimulants; Hippocampus; Humans; Nicotine

2007
Sex differences in drug abuse.
    Frontiers in neuroendocrinology, 2008, Volume: 29, Issue:1

    Topics: Animals; Cocaine; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Estrous Cycle; Ethanol; Female; Humans; Male; Models, Biological; Narcotics; Nicotine; Psychomotor Performance; Risk Factors; Sex Characteristics; Sex Chromosomes; Substance-Related Disorders

2008
Long-term consequences of maternal smoking and developmental chronic nicotine exposure.
    Frontiers in bioscience : a journal and virtual library, 2008, Jan-01, Volume: 13

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Birth Weight; Body Weight; Disease Models, Animal; Female; Humans; Learning; Maternal Exposure; Memory; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Smoking

2008
Nicotine and nicotinic system in hypoglutamatergic models of schizophrenia.
    Neurotoxicity research, 2007, Volume: 12, Issue:4

    Topics: Animals; Disease Models, Animal; Electrophysiology; Glutamic Acid; Humans; Nicotine; Receptors, Nicotinic; Schizophrenia; Schizophrenic Psychology; Smoking

2007
Perinatal psychoactive drug use: effects on gender, development, and function in offspring.
    Nebraska Symposium on Motivation. Nebraska Symposium on Motivation, 1984, Volume: 32

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amphetamines; Animals; Barbiturates; Disease Models, Animal; Drug Interactions; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Fetus; Humans; Male; Maternal-Fetal Exchange; Nicotine; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Psychotropic Drugs; Research Design; Sex Ratio; Teratogens

1984
Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics.
    Drugs & aging, 1997, Volume: 11, Issue:3

    Topics: Alzheimer Disease; Animals; Cognition; Cognition Disorders; Combined Modality Therapy; Disease Models, Animal; Humans; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parkinson Disease; Receptors, Nicotinic

1997
Nicotine self-administration in animals as a dependence model.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 1999, Volume: 1, Issue:1

    Topics: Animals; Behavior, Addictive; Disease Models, Animal; Limbic System; Nicotine; Receptors, Opioid; Reproducibility of Results; Self Administration; Tobacco Use Disorder; Ventral Tegmental Area

1999
Human and animal studies of schizophrenia-related gating deficits.
    Current psychiatry reports, 1999, Volume: 1, Issue:1

    Topics: Animals; Disease Models, Animal; Evoked Potentials, Auditory; Ganglionic Stimulants; Humans; Mental Processes; Nicotine; Rats; Reflex, Startle; Schizophrenia; Social Isolation

1999
Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety.
    Progress in neuro-psychopharmacology & biological psychiatry, 2000, Volume: 24, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety Disorders; Disease Models, Animal; Hippocampus; Maze Learning; Nicotine; Rats; Septum of Brain; Serotonin Receptor Agonists

2000
[Assessment of anti-tremorogenic drugs using nicotine-induced tail-tremor model and elucidation of the mechanism].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2001, Volume: 121, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Benzodiazepines; Disease Models, Animal; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Nitric Oxide Synthase; Rats; Receptors, N-Methyl-D-Aspartate; Tail; Tremor

2001
Risks and benefits of nicotine to aid smoking cessation in pregnancy.
    Drug safety, 2001, Volume: 24, Issue:4

    Topics: Animals; Disease Models, Animal; Female; Fetus; Humans; Nicotine; Pregnancy; Pregnancy Complications; Rats; Risk Assessment; Smoking Cessation

2001
Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, May-01, Volume: 22, Issue:9

    Topics: Animals; Behavior, Addictive; Brain Stem; Disease Models, Animal; Humans; Nerve Net; Nervous System; Nicotine; Nucleus Accumbens; Receptors, Nicotinic; Tobacco Use Disorder; Ventral Tegmental Area

2002
Model studies in tobacco carcinogenesis with the Syrian golden hamster.
    Progress in experimental tumor research, 1979, Volume: 24

    Topics: Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; Disease Models, Animal; Ethanolamines; Humans; Laryngeal Neoplasms; Mesocricetus; Neoplasms, Experimental; Nicotiana; Nicotine; Nitroso Compounds; Plants, Toxic; Respiratory Tract Neoplasms; Smoke

1979

Trials

1 trial(s) available for nicotine and Disease Models, Animal

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus

2016

Other Studies

646 other study(ies) available for nicotine and Disease Models, Animal

ArticleYear
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.
    Bioorganic & medicinal chemistry letters, 2004, Jul-16, Volume: 14, Issue:14

    Topics: Analgesics; Animals; Cells, Cultured; Disease Models, Animal; Ligands; Mice; Pain; Receptors, Nicotinic; Tetrahydroisoquinolines

2004
Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs.
    Bioorganic & medicinal chemistry, 2008, Jan-15, Volume: 16, Issue:2

    Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Molecular Structure; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship

2008
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries

2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
Analysis of electric cigarette liquid effect on mouse brain tumor growth through EGFR and ERK activation.
    PloS one, 2021, Volume: 16, Issue:9

    Topics: Animals; Astrocytes; Brain Neoplasms; Carcinogenesis; Cell Proliferation; Cells, Cultured; Cigarette Smoking; Disease Models, Animal; Electronic Nicotine Delivery Systems; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Glioblastoma; Heterografts; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nicotine; Phosphorylation; Prognosis; Propylene Glycol; Solutions; Solvents; Tumor Burden

2021
Role of cytokine and neurotrophic factors in nicotine addiction in the conditioned place preference paradigm.
    Neuroscience letters, 2021, 11-01, Volume: 764

    Topics: Animals; Brain-Derived Neurotrophic Factor; Conditioning, Psychological; Corpus Striatum; Disease Models, Animal; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; Humans; Injections, Intraperitoneal; Interleukin-10; Interleukin-1beta; Male; Mice; Neuroinflammatory Diseases; Nicotine; Prefrontal Cortex; Reward; Tobacco Use Disorder

2021
Does nicotine exposure during adolescence modify the course of schizophrenia-like symptoms? Behavioral analysis in a phencyclidine-induced mice model.
    PloS one, 2021, Volume: 16, Issue:9

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Locomotion; Male; Mice; Motor Activity; Nicotine; Phencyclidine; Recognition, Psychology; Schizophrenia; Sensory Gating

2021
Nicotine Administration Normalizes Behavioral and Neurophysiological Perturbations in the MAM Rodent Model of Schizophrenia.
    The international journal of neuropsychopharmacology, 2021, 12-08, Volume: 24, Issue:12

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Hippocampus; Male; Methylazoxymethanol Acetate; Nicotine; Prepulse Inhibition; Rats; Rats, Sprague-Dawley; Schizophrenia; Self Medication; Ventral Tegmental Area

2021
Ethanol interaction with α3β4 nicotinic acetylcholine receptors in neurons of the laterodorsal tegmentum.
    Alcoholism, clinical and experimental research, 2021, Volume: 45, Issue:12

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Neurons; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2021
Autonomic Regulation of Nociceptive and Immunologic Changes in a Mouse Model of Complex Regional Pain Syndrome.
    The journal of pain, 2022, Volume: 23, Issue:3

    Topics: Animals; Autonomic Nervous System; Chronic Pain; Complex Regional Pain Syndromes; Disease Models, Animal; Fractures, Bone; Hypertrophy; Immunoglobulin M; Mice; Nicotine; Nociception; Oxidopamine

2022
Repetitive Mild Traumatic Brain Injury in an Awake, Unanesthetized Mouse Model of Perinatal Nicotine Exposure Produces Transient Novelty-Seeking and Depression-Like Behaviors.
    Journal of neurotrauma, 2022, Volume: 39, Issue:13-14

    Topics: Animals; Brain Concussion; Depression; Disease Models, Animal; Exploratory Behavior; Female; Humans; Mice; Nicotine; Pregnancy; Wakefulness

2022
A mouse model of weight gain after nicotine withdrawal.
    Biochemical and biophysical research communications, 2022, 01-15, Volume: 588

    Topics: Agouti-Related Protein; Animals; Calorimetry; Cell Respiration; Disease Models, Animal; Energy Intake; Exenatide; Feeding Behavior; Gene Expression Regulation; Hypothalamus; Male; Mice, Inbred C57BL; Nicotine; RNA, Messenger; Substance Withdrawal Syndrome; Weight Gain

2022
Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells.
    Scientific reports, 2022, 01-07, Volume: 12, Issue:1

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Caspase 3; Caspase Inhibitors; Central Nervous System Stimulants; Cholinergic Neurons; Colitis, Ulcerative; Colon; Dendritic Cells; Deoxyglucose; Disease Models, Animal; Enzyme Inhibitors; Janus Kinase 2; Mice, Inbred BALB C; Neuroimmunomodulation; Neuropeptides; Nicotine; Oxazolone; rac1 GTP-Binding Protein; STAT3 Transcription Factor; Th2 Cells; Tyrphostins; Vagus Nerve

2022
Morphine Exposure Reduces Nicotine-Induced Upregulation of Nicotinic Receptors and Decreases Volitional Nicotine Intake in a Mouse Model.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2022, 07-13, Volume: 24, Issue:8

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Morphine; Nicotine; Receptors, Nicotinic; Reward; Up-Regulation; Ventral Tegmental Area

2022
Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema.
    Respiratory research, 2022, Mar-03, Volume: 23, Issue:1

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; H-2 Antigens; Histocompatibility Antigens Class I; Life Expectancy; Mice; Mice, Inbred C57BL; Nicotine; Pancreatic Elastase; Pulmonary Emphysema; RNA

2022
Methylphenidate Restores Behavioral and Neuroplasticity Impairments in the Prenatal Nicotine Exposure Mouse Model of ADHD: Evidence for Involvement of AMPA Receptor Subunit Composition and Synaptic Spine Morphology in the Hippocampus.
    International journal of molecular sciences, 2022, Jun-26, Volume: 23, Issue:13

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Female; Hippocampus; Methylphenidate; Mice; Neuronal Plasticity; Nicotine; Pregnancy; Receptors, AMPA

2022
Testing Association of Previously Implicated Gene Sets and Gene-Networks in Nicotine Exposed Mouse Models with Human Smoking Phenotypes.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2023, 04-06, Volume: 25, Issue:5

    Topics: Animals; Disease Models, Animal; Humans; Mice; Nicotine; Phenotype; Smoking; Tobacco Smoking

2023
Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity.
    Scientific reports, 2023, 02-04, Volume: 13, Issue:1

    Topics: Animals; Brain; COVID-19; Disease Models, Animal; Lung; Mice; Mice, Transgenic; Nervous System Diseases; Nicotine; RNA, Viral; SARS-CoV-2

2023
Using Nicotine in A Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition.
    Journal of visualized experiments : JoVE, 2023, 03-03, Issue:193

    Topics: Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition; Humans; Lung; Mice; Nicotine; Pulmonary Fibrosis; Silicon Dioxide; Silicosis

2023
Tobacco Alkaloid Assessment in a DSS-Induced Colitis Mouse Model with a Fully Humanized Immune System.
    International journal of molecular sciences, 2023, Mar-29, Volume: 24, Issue:7

    Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Immune System; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Nicotiana; Nicotine

2023
Nicotine Exposure in a Phencyclidine-Induced Mice Model of Schizophrenia: Sex-Selective Medial Prefrontal Cortex Protein Markers of the Combined Insults in Adolescent Mice.
    International journal of molecular sciences, 2023, Sep-27, Volume: 24, Issue:19

    Topics: Animals; Disease Models, Animal; Female; Male; Mice; Nicotine; Phencyclidine; Prefrontal Cortex; Schizophrenia; Synaptic Transmission

2023
Use of derived adipose stem cells to reduce complications of cutaneous scarring in smokers. An experimental model in rats.
    Acta cirurgica brasileira, 2019, Aug-19, Volume: 34, Issue:6

    Topics: Adipocytes; Adipose Tissue; Animals; Cicatrix; Disease Models, Animal; Graft Survival; Male; Necrosis; Nicotine; Rats

2019
Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine.
    The Journal of clinical investigation, 2019, 10-01, Volume: 129, Issue:10

    Topics: Adolescent; Adult; Animals; Disease Models, Animal; Electronic Nicotine Delivery Systems; Female; Homeostasis; Humans; Immunity, Innate; Lipid Metabolism; Lipidomics; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Nicotine; Phospholipids; Pulmonary Emphysema; Respiratory Mucosa; Smoke; Solvents

2019
Nicotine exerts neuroprotective effects by attenuating local inflammatory cytokine production following crush injury to rat sciatic nerves.
    European cytokine network, 2019, Jun-01, Volume: 30, Issue:2

    Topics: Animals; Crush Injuries; Cytokines; Disease Models, Animal; GAP-43 Protein; Inflammation Mediators; Interleukin-1beta; Male; Motor Activity; Nerve Regeneration; Neuroprotective Agents; Nicotine; Rats, Wistar; Sciatic Nerve; Sensory Receptor Cells; Tumor Necrosis Factor-alpha

2019
Photobiomodulation Increases Viability in Full-Thickness Grafts in Rats Submitted to Nicotine.
    Lasers in surgery and medicine, 2020, Volume: 52, Issue:5

    Topics: Animals; Disease Models, Animal; Ganglionic Stimulants; Graft Survival; Low-Level Light Therapy; Male; Nicotine; Rats; Rats, Wistar; Skin Transplantation; Wound Healing

2020
The Effect of Flavored E-cigarettes on Murine Allergic Airways Disease.
    Scientific reports, 2019, 09-20, Volume: 9, Issue:1

    Topics: Airway Remodeling; Animals; Bronchial Hyperreactivity; Bronchitis; Cola; Disease Models, Animal; E-Cigarette Vapor; Female; Flavoring Agents; Glycyrrhiza; Male; Mice; Mice, Inbred BALB C; Nicotine; Pyroglyphidae

2019
Differential patterns of alcohol and nicotine intake: Combined alcohol and nicotine binge consumption behaviors in mice.
    Alcohol (Fayetteville, N.Y.), 2020, Volume: 85

    Topics: Animals; Binge Drinking; Disease Models, Animal; Ethanol; Male; Mice; Mice, Inbred C57BL; Nicotine; Self Administration

2020
Effects of Developmental Nicotine Exposure on Frontal Cortical GABA-to-Non-GABA Neuron Ratio and Novelty-Seeking Behavior.
    Cerebral cortex (New York, N.Y. : 1991), 2020, 03-14, Volume: 30, Issue:3

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Exploratory Behavior; Female; Frontal Lobe; GABAergic Neurons; Memory Disorders; Memory, Short-Term; Mice; Nicotine; Nicotinic Agonists; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects

2020
Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal.
    Science advances, 2019, Volume: 5, Issue:10

    Topics: Animals; Anxiety; Disease Models, Animal; Locomotion; Male; Mice; Mice, Inbred C57BL; Microglia; NADPH Oxidase 2; Nicotine; Nucleus Accumbens; Organic Chemicals; Reactive Oxygen Species; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction; Substance Withdrawal Syndrome

2019
Differences in mechanisms underlying reinstatement of cigarette smoke extract- and nicotine-seeking behavior in rats.
    Neuropharmacology, 2020, 01-01, Volume: 162

    Topics: Animals; Behavior, Animal; Cues; Disease Models, Animal; Drug-Seeking Behavior; Extinction, Psychological; Male; Nicotiana; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Self Administration; Smoke; Smoking Cessation; Tobacco Products; Tobacco Use Disorder

2020
Synergistic benefits of Nicotine and Thymol in alleviating experimental rheumatoid arthritis.
    Life sciences, 2019, Dec-15, Volume: 239

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Drug Synergism; Freund's Adjuvant; Male; Nicotine; Rats; Rats, Wistar; Thymol

2019
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
    Neuroscience letters, 2020, 01-10, Volume: 715

    Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Male; Naloxone; Nicotine; Pain Perception; Pain Threshold; Rats; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome; Time Factors; Up-Regulation

2020
Nicotinic Mitigation of Neuroinflammation and Oxidative Stress After Chronic Sleep Deprivation.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Animals; Astrocytes; Blood-Brain Barrier; Cognition; Cytokines; Disease Models, Animal; Disease Susceptibility; Fluorescent Antibody Technique; Glycogen Synthase Kinase 3 beta; Hippocampus; Inflammation; Male; Mice; Microglia; Nicotine; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sleep Deprivation

2019
Nicotine attenuates concanavalin A-induced liver injury in mice by regulating the α7-nicotinic acetylcholine receptor in Kupffer cells.
    International immunopharmacology, 2020, Volume: 78

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Concanavalin A; Disease Models, Animal; Hepatitis, Autoimmune; Humans; Kupffer Cells; Liver; Male; Mice; NF-kappa B; Nicotine; Primary Cell Culture; Protective Agents; Signal Transduction

2020
Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis.
    Arteriosclerosis, thrombosis, and vascular biology, 2020, Volume: 40, Issue:2

    Topics: Animals; Blood Platelets; Carotid Arteries; Cotinine; Disease Models, Animal; Flow Cytometry; Follow-Up Studies; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Nicotine; Platelet Activation; Platelet Count; Smoke; Smoking; Smoking Water Pipes; Thrombosis; Time Factors

2020
Microglial activation increases cocaine self-administration following adolescent nicotine exposure.
    Nature communications, 2020, 01-16, Volume: 11, Issue:1

    Topics: Aminopyridines; Animals; Chemokine CX3CL1; Cocaine; Disease Models, Animal; Drug-Seeking Behavior; Electronic Nicotine Delivery Systems; Female; Gene Expression Regulation; Male; Microglia; Minocycline; Nicotine; Phenotype; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Reinforcement, Psychology; Reward; Self Administration; Synaptophysin

2020
Examination of nicotine and saccharin reward in the Goto-Kakizaki diabetic rat model.
    Neuroscience letters, 2020, 03-16, Volume: 721

    Topics: Animals; Conditioning, Psychological; Diabetes Mellitus, Type 2; Disease Models, Animal; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Rats, Wistar; Reward; Saccharin; Self Administration; Species Specificity; Sweetening Agents

2020
MicroRNA124-IL6R Mediates the Effect of Nicotine in Inflammatory Bowel Disease by Shifting Th1/Th2 Balance Toward Th1.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Nicotine; Receptors, Interleukin-6; Signal Transduction; Th1 Cells; Th1-Th2 Balance

2020
Rat bone mesenchymal stem cells exert antiproliferative effects on nicotine‑exposed T cells via iNOS production.
    Molecular medicine reports, 2020, Volume: 21, Issue:5

    Topics: Animals; Bone Marrow Cells; Cell Proliferation; Coculture Techniques; Disease Models, Animal; Gene Knockdown Techniques; Lentivirus; Male; Mesenchymal Stem Cells; Nicotine; Nitric Oxide Synthase Type II; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; T-Lymphocytes

2020
Photobiomodulation Decreases Hyperalgesia in Complex Regional Pain Syndrome: An Experimental Mouse Model Subjected to Nicotine.
    Lasers in surgery and medicine, 2020, Volume: 52, Issue:9

    Topics: Animals; Chronic Pain; Complex Regional Pain Syndromes; Disease Models, Animal; Hyperalgesia; Mice; Nicotine

2020
Pharmacological challenges examining the underlying mechanism of altered response inhibition and attention due to circadian disruption in adult Long-Evans rats.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 193

    Topics: Animals; Attention; Benzazepines; Choline O-Acetyltransferase; Chronobiology Disorders; Circadian Clocks; Circadian Rhythm; Cognition; Disease Models, Animal; Dopamine Antagonists; Female; Gene Expression; Impulsive Behavior; Male; Nicotine; Nicotinic Agonists; Period Circadian Proteins; Rats; Rats, Long-Evans; Reaction Time; Receptors, Dopamine D1; Salicylamides

2020
Intermedin
    Aging, 2020, 03-31, Volume: 12, Issue:7

    Topics: Aging; Animals; Aorta; Cell Transdifferentiation; Cholecalciferol; Disease Models, Animal; Male; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nicotine; Osteogenesis; Peptide Hormones; Rats; Rats, Sprague-Dawley; Sirtuin 1; Up-Regulation; Vascular Calcification

2020
Opposing effects of acute and repeated nicotine exposure on boldness in zebrafish.
    Scientific reports, 2020, 05-22, Volume: 10, Issue:1

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Zebrafish

2020
Sex-specific alterations in GABA receptor-mediated responses in laterodorsal tegmentum are associated with prenatal exposure to nicotine.
    Developmental neurobiology, 2020, Volume: 80, Issue:5-6

    Topics: Age Factors; Animals; Calcium; Disease Models, Animal; Female; Male; Mice; Nicotine; Nicotinic Agonists; Pontine Tegmentum; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, GABA-A; Receptors, GABA-B; Sex Factors; Smoking

2020
Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish.
    Molecules (Basel, Switzerland), 2020, Jun-30, Volume: 25, Issue:13

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzoates; Disease Models, Animal; Nicotine; Nicotinic Antagonists; Pyrrolidines; Receptors, Nicotinic; Reward; Swimming; Zebrafish

2020
Nicotine Modulates CTSS (Cathepsin S) Synthesis and Secretion Through Regulating the Autophagy-Lysosomal Machinery in Atherosclerosis.
    Arteriosclerosis, thrombosis, and vascular biology, 2020, Volume: 40, Issue:9

    Topics: Animals; Atherosclerosis; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cathepsins; Cell Line; Cell Movement; Disease Models, Animal; Exocytosis; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nicotine; rab GTP-Binding Proteins; Secretory Pathway; Signal Transduction

2020
Nicotine promotes angiogenesis in mouse brain after intracerebral hemorrhage.
    Neuroscience research, 2021, Volume: 170

    Topics: Animals; Brain; Cerebral Hemorrhage; Disease Models, Animal; Endothelial Cells; Mice; Mice, Inbred C57BL; Nicotine; Vascular Endothelial Growth Factor A

2021
The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model.
    Autism research : official journal of the International Society for Autism Research, 2020, Volume: 13, Issue:8

    Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Grooming; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Antagonists; Social Interaction

2020
Effect of nicotine on placental inflammation and apoptosis in preeclampsia-like model.
    Life sciences, 2020, Nov-15, Volume: 261

    Topics: Adult; Animals; Apoptosis; Case-Control Studies; Cytokines; Disease Models, Animal; Female; Humans; In Situ Nick-End Labeling; Inflammation; Lipopolysaccharides; Macrophages; Nicotine; Placenta; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation; Young Adult

2020
Frontal Cortical Monoamine Release, Attention, and Working Memory in a Perinatal Nicotine Exposure Mouse Model Following Kappa Opioid Receptor Antagonism.
    Cerebral cortex (New York, N.Y. : 1991), 2021, 01-01, Volume: 31, Issue:1

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Biogenic Monoamines; Disease Models, Animal; Female; Memory, Short-Term; Methylphenidate; Mice, Inbred C57BL; Nicotine; Norepinephrine; Receptors, Opioid, kappa; Reinforcement, Psychology

2021
Impact of prolonged nicotine administration on myocardial function and susceptibility to ischaemia-reperfusion injury in rats.
    Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:2

    Topics: Animals; Coronary Circulation; Disease Models, Animal; Drug Administration Schedule; Isolated Heart Preparation; Male; Mitochondria, Heart; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Reactive Oxygen Species; Ventricular Function, Left

2021
Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin.
    Scientific reports, 2020, 09-29, Volume: 10, Issue:1

    Topics: Animals; Autistic Disorder; Chromatin; CpG Islands; Disease Models, Animal; DNA Methylation; Dronabinol; Epigenesis, Genetic; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Male; Nicotine; Rats; Sequence Analysis, DNA; Spermatozoa

2020
The Influence of Tobacco Smoke/Nicotine on CYP2A Expression in Human and African Green Monkey Lungs.
    Molecular pharmacology, 2020, Volume: 98, Issue:6

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorocebus aethiops; Datasets as Topic; Disease Models, Animal; Gene Expression Profiling; Humans; Lung; Lung Neoplasms; Male; Microsomes, Liver; Nicotiana; Nicotine; Non-Smokers; RNA, Messenger; Sequence Analysis, RNA; Smoke; Smokers; Smoking; Steroid Hydroxylases; Tobacco Smoke Pollution

2020
Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2020, Volume: 41

    Topics: Adult; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Dependency, Psychological; Disease Models, Animal; Female; Humans; Male; Mice; Middle Aged; Nicotine; Nucleus Accumbens; Phencyclidine; Schizophrenia; Social Interaction

2020
Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin.
    Toxicology letters, 2021, Jan-01, Volume: 336

    Topics: Acetophenones; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Humans; Hyperplasia; Male; NADPH Oxidases; Nicotine; Oxidative Stress; Rats, Inbred F344; Reactive Oxygen Species; Signal Transduction; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium

2021
Chronic nicotine, but not suramin or resveratrol, partially remediates the mania-like profile of dopamine transporter knockdown mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2021, Volume: 42

    Topics: Animals; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Exploratory Behavior; Female; Humans; Male; Mania; Mice; Mice, Inbred C57BL; Nicotine; Resveratrol; Suramin

2021
Sex- and age-dependent differences in nicotine susceptibility evoked by developmental exposure to tobacco smoke and/or ethanol in mice.
    Journal of developmental origins of health and disease, 2021, Volume: 12, Issue:6

    Topics: Age Factors; Alcohol Drinking; Animals; Disease Models, Animal; Female; Male; Mice; Nicotine; Pregnancy; Sex Characteristics; Tobacco Smoke Pollution

2021
The reinforcement threshold and elasticity of demand for nicotine in an adolescent rat model of depression.
    Drug and alcohol dependence, 2021, 02-01, Volume: 219

    Topics: Animals; Depression; Disease Models, Animal; Elasticity; Humans; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Smokers; Smoking; Tobacco Use Disorder

2021
The role of α7-nicotinic acetylcholine receptor in a rat model of chronic nicotine-induced mechanical hypersensitivity.
    Neuroscience letters, 2021, 01-19, Volume: 743

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Chronic Pain; Cytidine Diphosphate Choline; Disease Models, Animal; Hyperalgesia; Male; Nicotine; Nootropic Agents; Rats; Rats, Sprague-Dawley; Spinal Cord; Touch

2021
The intervention effect of nicotine on cervical fibroblast-myofibroblast differentiation in lipopolysaccharide-induced preterm birth model through activating the TGF-β1/Smad3 pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 134

    Topics: Actins; Animals; Cell Differentiation; Cervical Ripening; Cervix Uteri; Collagen; Disease Models, Animal; Female; Lipopolysaccharides; Mice, Inbred C57BL; Myofibroblasts; Nicotine; Nicotinic Agonists; Phosphorylation; Pregnancy; Premature Birth; Proteolysis; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1

2021
Angiotensin II type 1 receptor mediates pulmonary hypertension and right ventricular remodeling induced by inhaled nicotine.
    American journal of physiology. Heart and circulatory physiology, 2021, 04-01, Volume: 320, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterial Pressure; Disease Models, Animal; E-Cigarette Vapor; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inhalation Exposure; Losartan; Male; Mice, Inbred C57BL; Nicotine; Pulmonary Artery; Receptor, Angiotensin, Type 1; Signal Transduction; Time Factors; Ventricular Function, Right; Ventricular Remodeling

2021
Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid.
    Behavioural brain research, 2021, 05-07, Volume: 405

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Depression; Disease Models, Animal; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex

2021
α7-nAChRs-mediated therapeutic angiogenesis accounts for the advantageous effect of low nicotine doses against myocardial infarction in rats.
    European journal of pharmacology, 2021, May-05, Volume: 898

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Angiogenesis Inducing Agents; Animals; Disease Models, Animal; Heme Oxygenase (Decyclizing); Isoproterenol; Male; Microvascular Density; Myocytes, Cardiac; Neovascularization, Physiologic; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitric Oxide Synthase Type II; Rats, Wistar; Signal Transduction; ST Elevation Myocardial Infarction; Vascular Endothelial Growth Factor A

2021
Effects of Nicotine and Tobacco-Related Products on the Feeding Behavior of the German Cockroach (Blattodea: Blattellidae).
    Journal of insect science (Online), 2021, Mar-01, Volume: 21, Issue:2

    Topics: Animals; Blattellidae; Conditioning, Classical; Disease Models, Animal; Feeding Behavior; Ganglionic Stimulants; Male; Nicotine; Olfactometry; Smell; Tobacco Use Disorder

2021
Repetitive Mild Traumatic Brain Injury in a Perinatal Nicotine Exposure Mouse Model of Attention Deficit Hyperactivity Disorder.
    Developmental neuroscience, 2021, Volume: 43, Issue:1

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain Concussion; Disease Models, Animal; Female; Mice; Nicotine; Pregnancy

2021
Sex differences in the induction of angiotensin converting enzyme 2 (ACE-2) in mouse lungs after e-cigarette vapor exposure and its relevance to COVID-19.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2021, Volume: 69, Issue:5

    Topics: Angiotensin-Converting Enzyme 2; Animals; Bronchoalveolar Lavage Fluid; Chemokine CCL2; COVID-19; Disease Models, Animal; E-Cigarette Vapor; Female; Humans; Interleukin-1beta; Lung; Male; Mice; Mice, Inbred BALB C; Nicotine; Risk Factors; Sex Factors; Vaping

2021
Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels.
    Scientific reports, 2021, 05-05, Volume: 11, Issue:1

    Topics: Animals; Carrier Proteins; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drosophila melanogaster; Mice; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Parkinson Disease; Tyrosine 3-Monooxygenase

2021
Differential effects of alkaloids on memory in rodents.
    Scientific reports, 2021, 05-10, Volume: 11, Issue:1

    Topics: Alkaloids; Animals; Cotinine; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Scopolamine; Spatial Memory

2021
Stimulation of α7 Nicotinic Acetylcholine Receptor by Nicotine Suppresses Decidual M1 Macrophage Polarization Against Inflammation in Lipopolysaccharide-Induced Preeclampsia-Like Mouse Model.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Adult; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Differentiation; Decidua; Disease Models, Animal; Female; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; Nicotine; Nicotinic Agonists; Pre-Eclampsia; Pregnancy

2021
Nicotine aggravates vascular adiponectin resistance via ubiquitin-mediated adiponectin receptor degradation in diabetic Apolipoprotein E knockout mouse.
    Cell death & disease, 2021, 05-18, Volume: 12, Issue:6

    Topics: Adiponectin; Animals; Apolipoproteins E; Disease Models, Animal; Humans; Male; Mice; Mice, Knockout; Nicotine; Transfection; Ubiquitin

2021
Partial Agonist Activity of Neonicotinoids on Rat Nicotinic Receptors: Consequences over Epinephrine Secretion and In Vivo Blood Pressure.
    International journal of molecular sciences, 2021, May-12, Volume: 22, Issue:10

    Topics: Adrenal Medulla; Animals; Arterial Pressure; Disease Models, Animal; Drug Partial Agonism; Epinephrine; Ganglia; Gene Expression Regulation; Guanidines; Insecticides; Male; Neonicotinoids; Nicotine; Rats; Receptors, Nicotinic; Thiazoles; Toxicity Tests, Subacute

2021
Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 207

    Topics: Alkaloids; Anabasine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Carbolines; Cotinine; Disease Models, Animal; Female; Harmine; Humans; Male; Nicotine; Pyridines; Solanaceae; Zebrafish

2021
A model of atherosclerosis using nicotine with balloon overdilation in a porcine.
    Scientific reports, 2021, 07-01, Volume: 11, Issue:1

    Topics: Angioplasty, Balloon; Animals; Atherosclerosis; Coronary Vessels; Disease Models, Animal; Male; Nicotine; Swine; Tunica Intima

2021
Targeting mitochondrial reactive oxygen species-mediated oxidative stress attenuates nicotine-induced cardiac remodeling and dysfunction.
    Scientific reports, 2021, 07-05, Volume: 11, Issue:1

    Topics: Animals; Antioxidants; Atrial Remodeling; Disease Models, Animal; Humans; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nicotine; Oxidative Stress; Rats; Reactive Oxygen Species; Ventricular Dysfunction, Left; Ventricular Remodeling

2021
Anthocyanins in Lycium ruthenicum Murray reduce nicotine withdrawal-induced anxiety and craving in mice.
    Neuroscience letters, 2021, 10-15, Volume: 763

    Topics: Animals; Anthocyanins; Anxiety; Craving; Disease Models, Animal; Humans; Lycium; Male; Mice; Network Pharmacology; Nicotine; Substance Withdrawal Syndrome

2021
Acquisition of nicotine self-administration in amphetamine and phencyclidine models of schizophrenia: A role for stress?
    Schizophrenia research, 2018, Volume: 194

    Topics: Amphetamine; Animals; Disease Models, Animal; Learning; Male; Motor Activity; Nicotine; Nicotinic Agonists; Phencyclidine; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Self Administration; Stress, Psychological; Tobacco Use Disorder

2018
Animal Research on Nicotine Reduction: Current Evidence and Research Gaps.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2017, Sep-01, Volume: 19, Issue:9

    Topics: Animals; Disease Models, Animal; Nicotine; Public Health; Research Design; Self Administration; Tobacco Use Disorder

2017
Chronic nicotine attenuates behavioral and synaptic plasticity impairments in a streptozotocin model of Alzheimer's disease.
    Neuroscience, 2017, 06-14, Volume: 353

    Topics: Alzheimer Disease; Animals; CA1 Region, Hippocampal; Cell Count; Disease Models, Animal; Locomotion; Long-Term Potentiation; Male; Neurons; Nicotine; Prefrontal Cortex; Rats, Wistar; Recognition, Psychology; Streptozocin; Synaptic Potentials

2017
Evidence of Altered Brain Responses to Nicotine in an Animal Model of Attention Deficit/Hyperactivity Disorder.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2017, Sep-01, Volume: 19, Issue:9

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Brain Chemistry; Disease Models, Animal; Male; Nicotine; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley

2017
Nicotine self-administration reverses cognitive deficits in a rat model for schizophrenia.
    Addiction biology, 2018, Volume: 23, Issue:2

    Topics: Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Female; Lipopolysaccharides; Male; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Schizophrenia; Schizophrenic Psychology; Self Administration

2018
MeCP2-deficient mice have reduced α4 and α6 nicotinic receptor mRNA and altered behavioral response to nicotinic agonists.
    Behavioural brain research, 2017, 07-14, Volume: 330

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Locomotion; Male; Mesencephalon; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Rett Syndrome; RNA, Messenger

2017
Electroencephalographic and biochemical long-lasting abnormalities in animal model of febrile seizure.
    Biochimica et biophysica acta. Molecular basis of disease, 2017, Volume: 1863, Issue:9

    Topics: Acetylcholinesterase; Animals; Behavior, Animal; Disease Models, Animal; Electrocardiography; GPI-Linked Proteins; Hippocampus; Male; Nicotine; Rats; Rats, Wistar; Seizures, Febrile; Time Factors

2017
Intrauterine growth retardation-associated syncytin b hypermethylation in maternal rat blood revealed by DNA methylation array analysis.
    Pediatric research, 2017, Volume: 82, Issue:4

    Topics: Animals; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Fetal Growth Retardation; Gene Expression Regulation, Developmental; High-Throughput Nucleotide Sequencing; Nicotine; Oligonucleotide Array Sequence Analysis; Placenta; Pregnancy; Pregnancy Proteins; Promoter Regions, Genetic; Rats, Wistar

2017
Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery.
    Brain research bulletin, 2018, Volume: 138

    Topics: Age Factors; Animals; Animals, Newborn; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Extinction, Psychological; Fear; Learning Disabilities; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists

2018
Nicotine-prevented learning and memory impairment in REM sleep-deprived rat is modulated by DREAM protein in the hippocampus.
    Brain and behavior, 2017, Volume: 7, Issue:6

    Topics: Animals; Disease Models, Animal; Ganglionic Stimulants; Hippocampus; Kv Channel-Interacting Proteins; Learning; Learning Disabilities; Male; Maze Learning; Memory; Memory Disorders; Nicotine; Rats; Rats, Sprague-Dawley; Repressor Proteins; Sleep Deprivation; Sleep, REM

2017
Effects of nicotine on corneal wound healing following acute alkali burn.
    PloS one, 2017, Volume: 12, Issue:6

    Topics: Actins; Animals; Burns, Chemical; Cell Line; Collagen Type I; Cornea; Corneal Injuries; Cotinine; Disease Models, Animal; Eye Burns; Female; Fibroblasts; Humans; Mice, Inbred BALB C; Nicotine; Protective Agents; Random Allocation; Receptors, Nicotinic; Sodium Hydroxide; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Wound Healing

2017
Nicotine Vapor Method to Induce Nicotine Dependence in Rodents.
    Current protocols in neuroscience, 2017, Jul-05, Volume: 80

    Topics: Animals; Disease Models, Animal; Electronic Nicotine Delivery Systems; Nebulizers and Vaporizers; Nicotine; Nicotinic Agonists; Rodentia; Tobacco Use Disorder

2017
The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats.
    Behavioural brain research, 2017, 08-30, Volume: 333

    Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Cholinergic Agonists; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Stress, Psychological; Substance Withdrawal Syndrome; Tobacco Use Disorder; Yohimbine

2017
Adolescent chronic variable social stress influences exploratory behavior and nicotine responses in male, but not female, BALB/cJ mice.
    Brain research bulletin, 2018, Volume: 138

    Topics: Age Factors; Analysis of Variance; Animals; Area Under Curve; Avoidance Learning; Choice Behavior; Corticosterone; Disease Models, Animal; Exploratory Behavior; Female; Hypothermia; Locomotion; Male; Maze Learning; Mice; Mice, Inbred BALB C; Nicotine; Nicotinic Agonists; Radioimmunoassay; Sex Characteristics; Stress, Psychological

2018
Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain.
    European journal of pain (London, England), 2018, Volume: 22, Issue:1

    Topics: Allosteric Regulation; Animals; Disease Models, Animal; Hydrocarbons, Brominated; Indole Alkaloids; Male; Mice; Neuralgia; Nicotine; Nicotinic Agonists; Receptors, Nicotinic

2018
Protective effects of Mentha spicata against nicotine-induced toxicity in liver and erythrocytes of Wistar rats.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2018, Volume: 43, Issue:1

    Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytoprotection; Disease Models, Animal; Erythrocytes; Lipid Peroxidation; Liver; Male; Mentha spicata; Nicotine; Oxidative Stress; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors

2018
Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal.
    Addiction biology, 2018, Volume: 23, Issue:5

    Topics: Amino Acids; Animals; Disease Models, Animal; Dopamine; Female; Glutamic Acid; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Sex Factors; Substance Withdrawal Syndrome; Tobacco Use Disorder

2018
Alteration of adolescent aversive nicotine response and anxiety-like behavior in nicotine-exposed rats during late lactation period.
    Behavioural brain research, 2018, Jan-30, Volume: 337

    Topics: Age Factors; Analysis of Variance; Animals; Anxiety; Avoidance Learning; Body Weight; Choice Behavior; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Food Preferences; Lactation; Male; Nicotine; Nicotinic Agonists; Quinine; Rats; Rats, Sprague-Dawley; Saccharin

2018
Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms.
    Molecular medicine reports, 2017, Volume: 16, Issue:6

    Topics: Alveolar Bone Loss; Animals; Cyclooxygenase 2; Disease Models, Animal; Iridoid Glucosides; Male; Nicotine; Osteocalcin; Protective Agents; Rats; Tumor Necrosis Factor-alpha

2017
Regular nicotine intake increased tooth movement velocity, osteoclastogenesis and orthodontically induced dental root resorptions in a rat model.
    International journal of oral science, 2017, Volume: 9, Issue:3

    Topics: Animals; Cone-Beam Computed Tomography; Disease Models, Animal; Interleukin-6; Male; Nicotine; Osteoclasts; Osteogenesis; Random Allocation; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction; Root Resorption; Tooth Movement Techniques

2017
Progressive modulation of accumbal neurotransmission and anxiety-like behavior following protracted nicotine withdrawal.
    Neuropharmacology, 2018, Volume: 128

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Corpus Striatum; Dendritic Spines; Diazepam; Disease Models, Animal; Evoked Potentials; Excitatory Postsynaptic Potentials; Locomotion; Male; Neurons; Nicotine; Nucleus Accumbens; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA; Substance Withdrawal Syndrome; Synaptic Transmission

2018
Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 364, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bridged-Ring Compounds; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Hyperalgesia; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Nicotine; Paclitaxel; Peripheral Nervous System Diseases; Receptors, Cholinergic; Taxoids

2018
Nicotine Augments the Beneficial Effects of Mesenchymal Stem Cell-based Therapy in Rat Model of Multiple Sclerosis.
    Immunological investigations, 2018, Volume: 47, Issue:2

    Topics: Animals; Cells, Cultured; Combined Modality Therapy; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Multiple Sclerosis; Nicotine; Rats; Rats, Wistar; Spinal Cord; Whooping Cough

2018
Stellate ganglion block ameliorates vascular calcification by inhibiting endoplasmic reticulum stress.
    Life sciences, 2018, Jan-15, Volume: 193

    Topics: Animals; Aorta; Autonomic Nerve Block; Calcium; Cholecalciferol; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Glycerophosphates; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nicotine; Nordefrin; Rats; Rats, Sprague-Dawley; Signal Transduction; Stellate Ganglion; Vascular Calcification

2018
Generalization of effects of environmental enrichment on seeking for different classes of drugs of abuse.
    Behavioural brain research, 2018, 04-02, Volume: 341

    Topics: Amphetamine-Related Disorders; Animals; Craving; Cues; Disease Models, Animal; Drug-Seeking Behavior; Environment; Generalization, Psychological; Heroin; Heroin Dependence; Housing, Animal; Male; Methamphetamine; Nicotine; Psychotropic Drugs; Rats, Sprague-Dawley; Self Administration; Tobacco Use Disorder

2018
Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats.
    Neuroscience letters, 2018, 03-06, Volume: 668

    Topics: Animals; Behavior, Addictive; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Ketamine; Male; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Self Administration; Tobacco Use Disorder

2018
Mito-Tempo prevents nicotine-induced exacerbation of ischemic brain damage.
    Journal of applied physiology (Bethesda, Md. : 1985), 2018, 07-01, Volume: 125, Issue:1

    Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Injuries; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Attack, Transient; Male; Nicotine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury

2018
Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia.
    Developmental neuroscience, 2018, Volume: 40, Issue:1

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Dopamine Agonists; Female; Glial Cell Line-Derived Neurotrophic Factor; Housing, Animal; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Quinpirole; Rats; Schizophrenia; Substance-Related Disorders

2018
aPDT for periodontitis treatment in ovariectomized rats under systemic nicotine.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 22

    Topics: Animals; Combined Modality Therapy; Dental Scaling; Disease Models, Animal; Female; Low-Level Light Therapy; Nicotine; Osteoclasts; Ovariectomy; Periodontitis; Phenothiazines; Photochemotherapy; Photosensitizing Agents; Random Allocation; RANK Ligand; Rats; Root Planing

2018
miR-296-3p Negatively Regulated by Nicotine Stimulates Cytoplasmic Translocation of c-Myc via MK2 to Suppress Chemotherapy Resistance.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2018, 04-04, Volume: 26, Issue:4

    Topics: 3' Untranslated Regions; Adult; Aged; Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Ectopic Gene Expression; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; MicroRNAs; Middle Aged; Neoplasms; Nicotine; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; RNA Interference; Signal Transduction; Xenograft Model Antitumor Assays

2018
Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal.
    Psychopharmacology, 2018, Volume: 235, Issue:7

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Infusion Pumps; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Substance Withdrawal Syndrome

2018
Impacts of cannabinoid receptor ligands on nicotine- and chronic mild stress-induced cognitive and depression-like effects in mice.
    Behavioural brain research, 2018, 07-16, Volume: 347

    Topics: Animals; Antidepressive Agents; Cannabinoid Receptor Modulators; Cognition; Depression; Disease Models, Animal; Male; Memory; Memory Disorders; Mice; Nicotine; Nicotinic Agonists; Nootropic Agents; Receptors, Cannabinoid; Stress, Psychological

2018
Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 102

    Topics: Allylbenzene Derivatives; Animals; Anisoles; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Male; Nicotine; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological

2018
Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro.
    Journal of the American Heart Association, 2018, 03-23, Volume: 7, Issue:6

    Topics: Animals; Apoptosis; Binding Sites; Bone Morphogenetic Protein 2; Cell Transdifferentiation; Cholecalciferol; Disease Models, Animal; Humans; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nicotine; Osteoblasts; Phenotype; Promoter Regions, Genetic; Rats, Wistar; Signal Transduction; Sp1 Transcription Factor; Transcriptional Activation; Vascular Calcification

2018
The interaction of the Chrna5 D398N variant with developmental nicotine exposure.
    Genes, brain, and behavior, 2018, Volume: 17, Issue:7

    Topics: Animals; Disease Models, Animal; Female; Gene-Environment Interaction; Male; Mice; Mice, Transgenic; Nicotine; Polymorphism, Single Nucleotide; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Nicotinic; Tobacco Use Disorder

2018
Cigarette smoke and nicotine effects on brain proinflammatory responses and behavioral and motor function in HIV-1 transgenic rats.
    Journal of neurovirology, 2018, Volume: 24, Issue:2

    Topics: AIDS Dementia Complex; Animals; Cigarette Smoking; Cognitive Dysfunction; Disease Models, Animal; Disease Progression; Female; Frontal Lobe; Gene Expression Regulation; HIV-1; Humans; Interleukin-1; Interleukin-6; Locomotion; Male; Nicotine; Psychomotor Performance; Rats; Rats, Inbred F344; Rats, Transgenic; Rotarod Performance Test; Tumor Necrosis Factor-alpha

2018
Nicotine-mediated neuroprotection of rat spinal networks against excitotoxicity.
    The European journal of neuroscience, 2018, Volume: 47, Issue:11

    Topics: Animals; Central Pattern Generators; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Motor Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Reflex; Spinal Cord; Spinal Injuries

2018
Attention and working memory deficits in a perinatal nicotine exposure mouse model.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Female; Male; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects

2018
Electrophysiological effects of nicotinic and electrical stimulation of intrinsic cardiac ganglia in the absence of extrinsic autonomic nerves in the rabbit heart.
    Heart rhythm, 2018, Volume: 15, Issue:11

    Topics: Animals; Disease Models, Animal; Electric Stimulation; Ganglia, Autonomic; Ganglionic Stimulants; Heart Atria; Heart Conduction System; Immunohistochemistry; Male; Myocardium; Nicotine; Nitric Oxide Synthase Type I; Rabbits

2018
Vitamin E attenuates nicotine- and noise-induced reproductive impairment in male albino Wistar rats.
    Andrologia, 2018, Volume: 50, Issue:7

    Topics: Animals; Antioxidants; Disease Models, Animal; Environmental Exposure; Humans; Infertility, Male; Male; Nicotine; Noise; Oxidative Stress; Rats; Rats, Wistar; Spermatozoa; Stress, Psychological; Testis; Testosterone; Tobacco Smoking; Vitamin E

2018
Maternal E-Cigarette Exposure Results in Cognitive and Epigenetic Alterations in Offspring in a Mouse Model.
    Chemical research in toxicology, 2018, 07-16, Volume: 31, Issue:7

    Topics: Aerosols; Animals; Behavior, Animal; Brain; Cognition; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Electronic Nicotine Delivery Systems; Epigenesis, Genetic; Female; Maternal Exposure; Mice; Mice, Inbred BALB C; Nicotine; Oxidoreductases, N-Demethylating; Pregnancy; Prenatal Exposure Delayed Effects

2018
Nicotine treatment ameliorates DSS-induced colitis by suppressing MAdCAM-1 expression and leukocyte recruitment.
    Journal of leukocyte biology, 2018, Volume: 104, Issue:5

    Topics: Animals; Cell Adhesion Molecules; Chemotaxis, Leukocyte; Colitis; Dextran Sulfate; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mucoproteins; Nicotine; Nicotinic Agonists

2018
Influence of neuropathic pain on nicotinic acetylcholine receptor plasticity and behavioral responses to nicotine in rats.
    Pain, 2018, Volume: 159, Issue:11

    Topics: Animals; Conditioning, Operant; Cues; Disease Models, Animal; Down-Regulation; Drug-Seeking Behavior; Ligation; Male; Maze Learning; Neuralgia; Nicotine; Nicotinic Agonists; Nociception; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology; RNA, Messenger; Self Administration; Time Factors

2018
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
    Journal of pharmacological sciences, 2018, Volume: 137, Issue:2

    Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbamazepine; Diazepam; Disease Models, Animal; Essential Tremor; Ethosuximide; Male; Mice, Inbred Strains; Nicotine; Phenobarbital; Propranolol; Pyridines; Valproic Acid

2018
Nicotine-Induced Neuroprotection in Rotenone In Vivo and In Vitro Models of Parkinson's Disease: Evidences for the Involvement of the Labile Iron Pool Level as the Underlying Mechanism.
    Neurotoxicity research, 2019, Volume: 35, Issue:1

    Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Embryo, Mammalian; Exploratory Behavior; Fluoresceins; Forelimb; Insecticides; Iron; Male; Medial Forebrain Bundle; Mesencephalon; Motor Activity; Nicotine; Nicotinic Agonists; Parkinson Disease; Pars Compacta; Rats; Rats, Sprague-Dawley; Rotenone; Tubulin; Tyrosine 3-Monooxygenase

2019
Continuous nicotine exposure does not affect resurgence of alcohol seeking in rats.
    PloS one, 2018, Volume: 13, Issue:8

    Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Drug Interactions; Drug-Seeking Behavior; Ethanol; Humans; Male; Nicotine; Rats; Rats, Long-Evans; Recurrence; Reinforcement, Psychology

2018
Rosmarinic acid inhibits nicotine-induced C-reactive protein generation by inhibiting NLRP3 inflammasome activation in smooth muscle cells.
    Journal of cellular physiology, 2019, Volume: 234, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; C-Reactive Protein; Cells, Cultured; Cinnamates; Depsides; Disease Models, Animal; Inflammasomes; Inflammation; Lipids; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nicotine; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rosmarinic Acid; Signal Transduction

2019
Dietary DNA Attenuates the Degradation of Elastin Fibers in the Aortic Wall in Nicotine-Administrated Mice.
    Journal of nutritional science and vitaminology, 2018, Volume: 64, Issue:4

    Topics: Adventitia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cardiovascular Agents; Dietary Supplements; Disease Models, Animal; DNA; Elastin; Endothelium, Vascular; Immunohistochemistry; Male; Matrix Metalloproteinase 2; Mice, Inbred C57BL; Nicotine; Oxidative Stress; Proteolysis

2018
Chronic nicotine administration restores brain region specific upregulation of oxytocin receptor binding levels in a G72 mouse model of schizophrenia.
    The European journal of neuroscience, 2019, Volume: 50, Issue:3

    Topics: Animals; Brain; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Nicotine; Protein Binding; Receptors, Oxytocin; Schizophrenia; Up-Regulation

2019
An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic α6β2* antagonist r-bPiDI.
    Drug and alcohol dependence, 2018, 12-01, Volume: 193

    Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Disease Models, Animal; Ethanol; Female; Naltrexone; Nicotine; Nicotinic Antagonists; Picolines; Pyridinium Compounds; Rats; Self Administration; Smoking Cessation Agents; Tobacco Use Disorder; Treatment Outcome; Varenicline

2018
Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6.
    Acta neuropathologica communications, 2018, 11-08, Volume: 6, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Aged, 80 and over; Animals; Animals, Newborn; Apoptosis; Brain; Cell Death; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression Regulation; Humans; Male; Mice; Mice, Transgenic; Neurons; Nicotine; Nicotinic Agonists; Parkinson Disease; Sirtuins

2018
Polysubstance addiction vulnerability in mental illness: Concurrent alcohol and nicotine self-administration in the neurodevelopmental hippocampal lesion rat model of schizophrenia.
    Addiction biology, 2020, Volume: 25, Issue:1

    Topics: Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Ethanol; Hippocampus; Male; Nicotine; Rats; Rats, Sprague-Dawley; Schizophrenia; Self Administration; Tobacco Use Disorder

2020
3-Furan-2-yl-N-p-tolyl-acrylamide, a highly selective positive allosteric modulator of α7 nicotinic receptors, produces anxiolytic-like activity in mice.
    Journal of psychopharmacology (Oxford, England), 2019, Volume: 33, Issue:5

    Topics: Acrylamides; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anxiety; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Disease Models, Animal; Drug Interactions; Furans; Male; Mice; Nicotine; Nicotinic Agonists

2019
Cannabinoid and nicotine exposure during adolescence induces sex-specific effects on anxiety- and reward-related behaviors during adulthood.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Animals; Anxiety; Benzoxazines; Conditioning, Operant; Disease Models, Animal; Female; Humans; Locomotion; Male; Mice; Morpholines; Naphthalenes; Nicotine; Reward; Sex Characteristics; Sucrose

2019
N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking.
    Addiction biology, 2020, Volume: 25, Issue:1

    Topics: Acetylcysteine; Animals; Craving; Cues; Disease Models, Animal; Drug-Seeking Behavior; Estrous Cycle; Extinction, Psychological; Female; Free Radical Scavengers; Male; Nicotine; Rats; Rats, Sprague-Dawley; Sex Factors; Substance Withdrawal Syndrome; Tobacco Use Disorder

2020
Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.
    Neuropharmacology, 2019, 05-01, Volume: 149

    Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Frontal Lobe; Humans; Hyperkinesis; Methylphenidate; Mice; Mice, Inbred C57BL; Motor Activity; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Nicotinic; Self Administration

2019
Adolescence versus adulthood: Differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse.
    Addiction biology, 2020, Volume: 25, Issue:1

    Topics: Age Factors; Analgesics, Opioid; Animals; Brain; Cocaine; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Dronabinol; Ganglionic Stimulants; Male; Microdialysis; Morphine; Nicotine; Nucleus Accumbens; Psychotropic Drugs; Rats; Substance-Related Disorders; Synaptic Transmission

2020
Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.
    Biochemical and biophysical research communications, 2019, 04-23, Volume: 512, Issue:1

    Topics: Aldehydes; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cotinine; Cyclin-Dependent Kinase Inhibitor p21; Cytochrome P450 Family 2; Disease Models, Animal; Fatty Liver, Alcoholic; Female; Hepatocytes; Liver Regeneration; Mice; Mice, Knockout; Nicotine; Perilipin-2; Reactive Oxygen Species; Signal Transduction; Up-Regulation

2019
Nicotine Self-administration Is Not Increased in the Methylazoxymethanol Acetate Rodent Model of Schizophrenia.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020, 02-06, Volume: 22, Issue:2

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Methylazoxymethanol Acetate; Nicotine; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Schizophrenia; Self Administration; Sucrose

2020
In utero exposure to nicotine abolishes the postnatal response of the cardiac sodium current to isoproterenol in newborn rabbit atrium.
    Heart rhythm, 2019, Volume: 16, Issue:4

    Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Heart Atria; Isoproterenol; Long QT Syndrome; Myocytes, Cardiac; Nicotine; Patch-Clamp Techniques; Pregnancy; Pregnancy, Animal; Rabbits; Sinoatrial Node; Sodium

2019
Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus.
    Molecular medicine reports, 2019, Volume: 19, Issue:5

    Topics: Animals; Behavior, Animal; Biomarkers; Depressive Disorder; Disease Models, Animal; Female; Gene Expression; Hippocampus; Maternal Exposure; Neurotransmitter Agents; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats

2019
Perinatal nicotine exposure impairs learning of a skilled forelimb reaching task in male but not female adult mice.
    Behavioural brain research, 2019, 07-23, Volume: 367

    Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Motor Skills; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Sex Characteristics

2019
Nicotine improved the olfactory impairment in MPTP-induced mouse model of Parkinson's disease.
    Neurotoxicology, 2019, Volume: 73

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Choline O-Acetyltransferase; Cholinergic Neurons; Disease Models, Animal; Dopaminergic Neurons; Locomotion; Male; Mice, Inbred C57BL; MPTP Poisoning; Nicotine; Nicotinic Agonists; Olfactory Bulb; Olfactory Perception; Signal Transduction; Smell; Tyrosine 3-Monooxygenase

2019
Acetylcholine receptor agonist effect on seizure activity and GABAergic mechanisms involved in prolonged febrile seizure development in an animal model.
    Brain research bulletin, 2019, Volume: 149

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinergic Agonists; Disease Models, Animal; Female; GABAergic Neurons; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Hippocampus; Male; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Nicotinic; Seizures, Febrile; Synaptic Transmission

2019
Synergistic anticataleptic effect of imipramine and nicotine in a rotenone-induced rat model.
    Psychopharmacology, 2019, Volume: 236, Issue:11

    Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Imipramine; Insecticides; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra

2019
Nicotine prevents anxiety-like behavioral responses in zebrafish.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 08-30, Volume: 94

    Topics: Animals; Anxiety; Behavior, Animal; Cues; Disease Models, Animal; Female; Locomotion; Male; Nicotine; Zebrafish

2019
Effect of High Voltage Pulsed Current on the integration of total skin grafts in rats submitted to nicotine action.
    Journal of tissue viability, 2019, Volume: 28, Issue:3

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Electric Stimulation Therapy; Male; Nicotine; Rats; Rats, Wistar; Skin Transplantation; Wound Healing

2019
Nicotine Improves Survivability, Hypotension, and Impaired Adenosinergic Renal Vasodilations in Endotoxic Rats: Role of α7-nAChRs/HO-1 Pathway.
    Shock (Augusta, Ga.), 2020, Volume: 53, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Disease Models, Animal; Endotoxemia; Female; Heme Oxygenase-1; Hypotension; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Renal Circulation; Signal Transduction; Vasodilation

2020
Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor.
    Journal of immunology (Baltimore, Md. : 1950), 2019, 07-15, Volume: 203, Issue:2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Line; Disease Models, Animal; Hyperalgesia; Inflammation; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nicotine; Osteoarthritis; Pain; Phosphatidylinositol 3-Kinases; RAW 264.7 Cells; Signal Transduction; Up-Regulation

2019
Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice.
    American journal of physiology. Heart and circulatory physiology, 2019, 08-01, Volume: 317, Issue:2

    Topics: Animals; Atherosclerosis; Disease Models, Animal; DNA, Mitochondrial; Electronic Nicotine Delivery Systems; Inhalation Exposure; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Mutation; Myocytes, Cardiac; Nicotine; Nicotinic Agonists; Oxidative Stress; Plaque, Atherosclerotic; Reactive Oxygen Species; Stroke Volume; Transcriptome; Vaping; Ventricular Dysfunction, Left; Ventricular Function, Left

2019
Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:10

    Topics: Animals; Animals, Newborn; Apnea; Biguanides; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Humans; Infant, Newborn; Lung; Male; Nerve Fibers, Unmyelinated; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; RNA, Messenger; Serotonin; Serotonin 5-HT3 Receptor Agonists; Sudden Infant Death

2019
Recent Updates in Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 2011

    Topics: Animals; Disease Models, Animal; Male; Nicotine; Rats; Self Stimulation; Substance Withdrawal Syndrome; Symptom Assessment; Tobacco Use Disorder

2019
Methods for Evaluating the Interaction Between Social Stress and Environmental Enrichment in Animal Models of Nicotine Addiction.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 2011

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Environmental Exposure; Male; Nicotine; Rodentia; Stress, Psychological; Tobacco Use Disorder

2019
Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior.
    Addiction biology, 2020, Volume: 25, Issue:5

    Topics: Acetylcysteine; Animals; Astrocytes; Conditioning, Psychological; Disease Models, Animal; Drug-Seeking Behavior; Glial Fibrillary Acidic Protein; Glutamic Acid; Male; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Signal Transduction; Tumor Necrosis Factor-alpha

2020
Role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission.
    Addiction biology, 2020, Volume: 25, Issue:5

    Topics: Age Factors; Animals; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Electrophysiological Phenomena; Genetic Background; Male; Microdialysis; Nicotine; Nucleus Accumbens; Rats; Rats, Inbred F344; Rats, Inbred Lew

2020
A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers.
    Journal of neuroscience methods, 2019, 10-01, Volume: 326

    Topics: Aerosols; Animals; Apolipoproteins E; Behavior, Animal; Cotinine; Disease Models, Animal; Electronic Nicotine Delivery Systems; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Vaping

2019
Effects of nicotine on markers of bone turnover in ovariectomized rats.
    The Pan African medical journal, 2019, Volume: 33

    Topics: Amino Acids; Animals; Biomarkers; Bone and Bones; Bone Density; Bone Remodeling; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Nicotine; Osteoblasts; Osteocalcin; Osteoclasts; Osteoporosis; Ovariectomy; Rats; Rats, Wistar

2019
Acquisition and long-term retention of spatial learning in the human immunodeficiency virus-1 transgenic rat: effects of repeated nicotine treatment.
    Journal of neurovirology, 2013, Volume: 19, Issue:2

    Topics: AIDS Dementia Complex; Animals; Disease Models, Animal; Drug Administration Schedule; Founder Effect; HIV-1; Injections, Subcutaneous; Male; Maze Learning; Memory, Long-Term; Nicotine; Rats; Rats, Inbred F344; Rats, Transgenic; Retention, Psychology

2013
Nicotine-induced cessation of embryonic development is reversed by γ-tocotrienol in mice.
    Medical science monitor basic research, 2013, Mar-06, Volume: 19

    Topics: Animals; Blastocyst; Chromans; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo Culture Techniques; Embryonic Development; Female; Lipid Peroxidation; Malondialdehyde; Mice; Nicotine; Thiobarbituric Acid Reactive Substances; Time Factors; Vitamin E

2013
Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; Base Sequence; Disease Models, Animal; DNA Primers; Female; Killer Cells, Natural; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Nicotine; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction

2013
Estrogen normalizes perinatal nicotine-induced hypertensive responses in adult female rat offspring.
    Hypertension (Dallas, Tex. : 1979), 2013, Volume: 61, Issue:6

    Topics: Animals; Animals, Newborn; Aorta, Thoracic; Blood Pressure; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Estrogens; Female; Follow-Up Studies; Hypertension; Male; Nicotine; Pregnancy; Pregnancy, Animal; Rats; Reactive Oxygen Species; Vascular Resistance; Vasoconstriction

2013
The role of the cholinergic system in the signal attenuation rat model of obsessive-compulsive disorder.
    Psychopharmacology, 2013, Volume: 230, Issue:1

    Topics: Acetylcholine; Animals; Behavior, Animal; Compulsive Behavior; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Mecamylamine; Nicotine; Obsessive-Compulsive Disorder; Oxotremorine; Physostigmine; Rats; Rats, Sprague-Dawley; Scopolamine

2013
Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling.
    American journal of physiology. Heart and circulatory physiology, 2013, Aug-15, Volume: 305, Issue:4

    Topics: Animals; Antioxidants; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Cell Line; Chemokine CCL2; Disease Models, Animal; Dose-Response Relationship, Drug; Foam Cells; Humans; Inflammation Mediators; Interleukin-6; Lipopolysaccharide Receptors; Lipoproteins, LDL; Macrophages; Mice; Mice, Knockout; Nicotine; Plaque, Atherosclerotic; PPAR gamma; Protein Kinase C-delta; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation

2013
The histidine triad nucleotide binding 1 protein is involved in nicotine reward and physical nicotine withdrawal in mice.
    Neuroscience letters, 2013, Aug-29, Volume: 550

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Male; Mice; Mice, Knockout; Nerve Tissue Proteins; Nicotine; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder

2013
Nicotinic receptor agonists reduce L-DOPA-induced dyskinesias in a monkey model of Parkinson's disease.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 347, Issue:1

    Topics: Animals; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Nicotine; Nicotinic Agonists; Parkinson Disease; Receptors, Nicotinic; Saimiri

2013
Nicotine is more addictive, not more cognitively therapeutic in a neurodevelopmental model of schizophrenia produced by neonatal ventral hippocampal lesions.
    Addiction biology, 2014, Volume: 19, Issue:6

    Topics: Analysis of Variance; Animals; Animals, Newborn; Conditioning, Operant; Diagnosis, Dual (Psychiatry); Disease Models, Animal; Drug-Seeking Behavior; Hippocampus; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Reinforcement Schedule; Schizophrenic Psychology; Self Administration; Tobacco Use Disorder

2014
Effects of nicotine on cardiovascular remodeling in a mouse model of systemic hypertension.
    Cardiovascular toxicology, 2013, Volume: 13, Issue:4

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Disease Models, Animal; Hypertension; Infusion Pumps; Male; Mice; Mice, Inbred C57BL; Nicotine; Treatment Outcome; Ventricular Remodeling

2013
Repeated transcranial direct current stimulation prevents abnormal behaviors associated with abstinence from chronic nicotine consumption.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:4

    Topics: Age Factors; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Drinking; Eating; Female; Maze Learning; Memory; Mental Disorders; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Recognition, Psychology; Substance Withdrawal Syndrome; Swimming; Transcranial Magnetic Stimulation

2014
Pharmacological cholinergic stimulation as a therapeutic tool in experimental necrotizing pancreatitis.
    Pancreas, 2014, Volume: 43, Issue:1

    Topics: Animals; Cholinergic Agents; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glycodeoxycholic Acid; HMGB1 Protein; Humans; Male; Neostigmine; Nicotine; Pancreas; Pancreatitis, Acute Necrotizing; Peroxidase; Physostigmine; Rats; Rats, Wistar

2014
Musk shrews selectively bred for motion sickness display increased anesthesia-induced vomiting.
    Physiology & behavior, 2014, Jan-30, Volume: 124

    Topics: Animals; Breeding; Copper Sulfate; Disease Models, Animal; Emetics; Female; Isoflurane; Male; Motion Sickness; Nicotine; Shrews; Species Specificity; Vomiting

2014
New experimental model of exposure to environmental tobacco smoke.
    Acta cirurgica brasileira, 2013, Volume: 28, Issue:12

    Topics: Animals; Disease Models, Animal; Environmental Exposure; Equipment Design; Lung; Male; Nicotine; Rats, Wistar; Reproducibility of Results; Smoking; Time Factors; Tobacco Smoke Pollution

2013
Detrimental effects of acute nicotine on the response-withholding performance of spontaneously hypertensive and Wistar Kyoto rats.
    Psychopharmacology, 2014, Volume: 231, Issue:12

    Topics: Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Dietary Sucrose; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Inhibition, Psychological; Models, Neurological; Nicotine; Nicotinic Agonists; Rats, Inbred SHR; Rats, Inbred WKY; Reinforcement Schedule; Reinforcement, Psychology; Time Factors

2014
Chronic nicotine improves short-term memory selectively in a G72 mouse model of schizophrenia.
    British journal of pharmacology, 2014, Volume: 171, Issue:7

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Carrier Proteins; Cognition; Disease Models, Animal; Drug Administration Schedule; Genotype; Humans; Intracellular Signaling Peptides and Proteins; Memory, Short-Term; Mice; Mice, Transgenic; Neural Inhibition; Nicotine; Nicotinic Agonists; Nootropic Agents; Phenotype; Prosencephalon; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Social Behavior; Time Factors

2014
Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches.
    Neuropharmacology, 2014, Volume: 81

    Topics: Analysis of Variance; Animals; Anxiety; Baclofen; Disease Models, Animal; Dorsal Raphe Nucleus; Dose-Response Relationship, Drug; GABA-B Receptor Antagonists; Gene Expression Regulation; Male; Mice; Mice, Knockout; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Receptors, GABA-B; Septal Nuclei

2014
Transgenerational transmission of hyperactivity in a mouse model of ADHD.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Feb-19, Volume: 34, Issue:8

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease Models, Animal; Environment; Female; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Motor Activity; Nicotine; Nicotinic Agonists; Risk Factors

2014
The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice.
    Psychopharmacology, 2014, Volume: 231, Issue:15

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cotinine; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Hippocampus; Lobeline; Male; Mice, Inbred C57BL; Motor Activity; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Norepinephrine; Prefrontal Cortex; Receptors, Nicotinic; Substance Withdrawal Syndrome; Swimming; Tobacco Use Disorder

2014
Operant self-administration of alcohol and nicotine in a preclinical model of co-abuse.
    Psychopharmacology, 2014, Volume: 231, Issue:20

    Topics: Alcoholism; Animals; Behavior, Addictive; Conditioning, Operant; Disease Models, Animal; Ethanol; Male; Naltrexone; Nicotine; Rats; Rats, Long-Evans; Self Administration; Smoking

2014
Tobacco particulate matter self-administration in rats: differential effects of tobacco type.
    Addiction biology, 2015, Volume: 20, Issue:2

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug-Seeking Behavior; Male; Motivation; Nicotiana; Nicotine; Nicotinic Agonists; Particulate Matter; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Self Administration; Tobacco Use Disorder

2015
Nicotine-stimulated release of [3H]norepinephrine is reduced in the hippocampus of an animal model of attention-deficit/hyperactivity disorder, the spontaneously hypertensive rat.
    Brain research, 2014, Jul-14, Volume: 1572

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Hippocampus; Male; Nicotine; Nicotinic Agonists; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Species Specificity; Tritium

2014
Maternal nicotine exposure exacerbates neonatal hyperoxia-induced lung fibrosis in rats.
    Neonatology, 2014, Volume: 106, Issue:2

    Topics: Animals; Animals, Newborn; Collagen; Connective Tissue Growth Factor; Disease Models, Animal; Female; Gestational Age; Hyperoxia; Lung; Maternal Exposure; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Pulmonary Fibrosis; Rats, Sprague-Dawley; Risk Factors; Time Factors

2014
Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.
    Neuropharmacology, 2014, Volume: 85

    Topics: Animals; Anxiety; Aryl Hydrocarbon Hydroxylases; Conditioning, Psychological; Cytochrome P450 Family 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Male; Mecamylamine; Methoxsalen; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reward; Severity of Illness Index; Substance Withdrawal Syndrome; Tobacco Use Disorder

2014
Effects of chronic mild stress on the development of drug dependence in rats.
    Behavioural pharmacology, 2014, Volume: 25, Issue:5-6

    Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumazenil; GABA Modulators; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Substance Withdrawal Syndrome; Substance-Related Disorders

2014
IV nicotine self-administration in rats using a consummatory operant licking response: sensitivity to serotonergic, glutaminergic and histaminergic drugs.
    Progress in neuro-psychopharmacology & biological psychiatry, 2014, Oct-03, Volume: 54

    Topics: Administration, Intravenous; Animals; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Forelimb; Motor Activity; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Self Administration; Smoking; Tobacco Use Disorder; Tongue

2014
Low-dose nicotine self-administration is reduced in adult male rats naïve to high doses of nicotine: implications for nicotine product standards.
    Experimental and clinical psychopharmacology, 2014, Volume: 22, Issue:5

    Topics: Animals; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Self Administration; Smoking

2014
Time-course of extracellular nicotine and cotinine levels in rat brain following administration of nicotine: effects of route and ethanol coadministration.
    Psychopharmacology, 2015, Volume: 232, Issue:3

    Topics: Alcoholism; Animals; Brain; Cotinine; Disease Models, Animal; Ethanol; Female; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Tobacco Use Disorder

2015
Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 125

    Topics: Animals; Disease Models, Animal; Exploratory Behavior; Hippocampus; Male; Microfilament Proteins; Mossy Fibers, Hippocampal; Motor Activity; Nerve Tissue Proteins; Neuronal Plasticity; Nicotine; Phenotype; Phobic Disorders; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y

2014
The experimental autoimmune encephalomyelitis disease course is modulated by nicotine and other cigarette smoke components.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Acrolein; Animals; Anti-Inflammatory Agents; Cells, Cultured; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Nicotiana; Nicotine; Peptides; Smoke; Smoking

2014
Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Nov-15, Volume: 307, Issue:10

    Topics: Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Azoxymethane; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gastrointestinal Agents; Inflammation Mediators; Interleukin-6; Intestinal Mucosa; Male; Mice, Inbred BALB C; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; RNA, Messenger; Severity of Illness Index; STAT3 Transcription Factor; Time Factors; Tumor Necrosis Factor-alpha

2014
Direct effects of recurrent hypoglycaemia on adrenal catecholamine release.
    Diabetes & vascular disease research, 2015, Volume: 12, Issue:1

    Topics: Acetylcholine; Adrenal Glands; Animals; Blood Glucose; Cholinergic Agonists; Disease Models, Animal; Down-Regulation; Electric Stimulation; Epinephrine; Hypoglycemia; Male; Muscarinic Agonists; Nicotine; Norepinephrine; Perfusion; Pilocarpine; Rats, Sprague-Dawley; Receptors, Cholinergic; Recurrence; Splanchnic Nerves

2015
Maternal nicotine exposure during gestation and lactation induces kidney injury and fibrosis in rat offspring.
    Pediatric research, 2015, Volume: 77, Issue:1-1

    Topics: Animals; Body Weight; Collagen; Connective Tissue Growth Factor; Disease Models, Animal; Female; Fibrosis; Kidney; Maternal Exposure; Nicotine; Organ Size; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Smoking

2015
Ventral hippocampal nicotinic acetylcholine receptors mediate stress-induced analgesia in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2015, Jan-02, Volume: 56

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Male; Mecamylamine; Mice; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociception; Pain Measurement; Pain Threshold; Reaction Time; Receptors, Nicotinic; Stress, Psychological; Time Factors

2015
Nicotine effects in adolescence and adulthood on cognition and α₄β₂-nicotinic receptors in the neonatal ventral hippocampal lesion rat model of schizophrenia.
    Psychopharmacology, 2015, Volume: 232, Issue:10

    Topics: Administration, Cutaneous; Age Factors; Animals; Animals, Newborn; Cognition; Disease Models, Animal; Female; Hippocampus; Male; Maze Learning; Nicotine; Pregnancy; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Schizophrenia; Treatment Outcome

2015
Thyroid hormone attenuates vascular calcification induced by vitamin D3 plus nicotine in rats.
    Calcified tissue international, 2015, Volume: 96, Issue:1

    Topics: Animals; Bone and Bones; Bone Remodeling; Cholecalciferol; Disease Models, Animal; Male; Nicotine; Osteopontin; Rats, Sprague-Dawley; Thyroid Hormones; Vascular Calcification

2015
Inflammation-induced increase in nicotinic acetylcholine receptor current in cutaneous nociceptive DRG neurons from the adult rat.
    Neuroscience, 2015, Jan-22, Volume: 284

    Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Hindlimb; Inflammation; Male; Membrane Potentials; Neuroanatomical Tract-Tracing Techniques; Nicotine; Nicotinic Agonists; Nociceptors; Patch-Clamp Techniques; Rats, Sprague-Dawley; Receptors, Nicotinic; Sensory System Agents; Skin

2015
Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.
    Neuropharmacology, 2015, Volume: 90

    Topics: Animals; Anxiety; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; Male; Mecamylamine; Mice, Inbred BALB C; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, GABA-A; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tobacco Use Disorder

2015
Anxiogenic-like effects of chronic nicotine exposure in zebrafish.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 139 Pt B

    Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Female; Humans; Hydrocortisone; Male; Nicotine; Nicotinic Agonists; Social Behavior; Substance-Related Disorders; Zebrafish

2015
Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015, Volume: 17, Issue:11

    Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Subcutaneous; Magnetic Resonance Imaging; Male; Nicotine; Rats; Rats, Sprague-Dawley; Smoking

2015
Antidepressant-like effects of the cannabinoid receptor ligands in the forced swimming test in mice: mechanism of action and possible interactions with cholinergic system.
    Behavioural brain research, 2015, May-01, Volume: 284

    Topics: Animals; Antidepressive Agents; Cannabinoids; Depressive Disorder; Disease Models, Animal; Indoles; Ligands; Male; Mice; Motor Activity; Nicotine; Oleic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Scopolamine; Swimming

2015
Perinatal nicotine exposure suppresses PPARγ epigenetically in lung alveolar interstitial fibroblasts.
    Molecular genetics and metabolism, 2015, Volume: 114, Issue:4

    Topics: Animals; Azacitidine; Base Sequence; Cells, Cultured; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Fibroblasts; Fibronectins; Humans; Lung; Methyl-CpG-Binding Protein 2; Molecular Sequence Data; Nicotine; PPAR gamma; Pregnancy; Promoter Regions, Genetic; Pulmonary Alveoli; Rats; RNA, Messenger; Smoking; Up-Regulation

2015
Effect of nicotine on neuronal dysfunction induced by intracerebroventricular infusion of amyloid-β peptide in rats.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:2

    Topics: Amyloid beta-Peptides; Animals; Brain; Choline O-Acetyltransferase; Disease Models, Animal; Infusions, Intraventricular; Male; Maze Learning; Memory; Memory Disorders; Neurons; Nicotine; Nicotinic Agonists; Rats; Rats, Inbred F344

2015
The Alteration of Neonatal Raphe Neurons by Prenatal-Perinatal Nicotine. Meaning for Sudden Infant Death Syndrome.
    American journal of respiratory cell and molecular biology, 2015, Volume: 53, Issue:4

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infant; Maternal-Fetal Exchange; Mice; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Raphe Nuclei; Smoking; Sudden Infant Death

2015
Role of α5-containing nicotinic receptors in neuropathic pain and response to nicotine.
    Neuropharmacology, 2015, Volume: 95

    Topics: Animals; Cold Temperature; Disease Models, Animal; Hot Temperature; Hyperalgesia; Ligation; Male; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Nicotine; Nicotinic Agonists; Nociception; Pain Threshold; Random Allocation; Receptors, Nicotinic; Sciatic Nerve; Spinal Cord; Thalamus; Touch

2015
Nicotine ameliorates experimental severe acute pancreatitis via enhancing immunoregulation of CD4+ CD25+ regulatory T cells.
    Pancreas, 2015, Volume: 44, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Interleukin-2 Receptor alpha Subunit; Male; Mice, Inbred C57BL; Nicotine; Pancreas; Pancreatitis, Acute Necrotizing; Phenotype; Severity of Illness Index; T-Lymphocytes, Regulatory; Taurocholic Acid; Time Factors

2015
Nicotinic Mechanisms Modulate Ethanol Withdrawal and Modify Time Course and Symptoms Severity of Simultaneous Withdrawal from Alcohol and Nicotine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:10

    Topics: Animals; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Female; Habenula; Interpeduncular Nucleus; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Substance Withdrawal Syndrome; Time Factors

2015
Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.
    Neuropharmacology, 2015, Volume: 99

    Topics: Animals; Benzazepines; Brain Mapping; Catheters, Indwelling; Cohort Studies; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Gyrus Cinguli; Haloperidol; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Parietal Lobe; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Self Administration; Tobacco Use Disorder

2015
The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys.
    Biological psychiatry, 2015, Oct-01, Volume: 78, Issue:7

    Topics: Animals; Brain; CHO Cells; Cricetulus; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Feeding Behavior; HEK293 Cells; Humans; Indoles; Male; Nicotine; Nicotinic Agonists; Oxadiazoles; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Saimiri; Self Administration; Tobacco Use Disorder

2015
Evidence for a role for α6(∗) nAChRs in l-dopa-induced dyskinesias using Parkinsonian α6(∗) nAChR gain-of-function mice.
    Neuroscience, 2015, Jun-04, Volume: 295

    Topics: Adrenergic Agents; Analysis of Variance; Animals; Antiparkinson Agents; Benserazide; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Levodopa; Male; Mice; Mice, Transgenic; Nicotine; Nicotinic Agonists; Oxidopamine; Parkinsonian Disorders; Protein Binding; Receptors, Nicotinic

2015
Endogenous ghrelin attenuates pressure overload-induced cardiac hypertrophy via a cholinergic anti-inflammatory pathway.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:6

    Topics: Analysis of Variance; Animals; Atropine Derivatives; Cardiomegaly; Cholinergic Agents; Disease Models, Animal; Ghrelin; Mice; Mice, Knockout; Nicotine; Random Allocation; Reference Values; Signal Transduction; Ventricular Pressure

2015
Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Apr-15, Volume: 35, Issue:15

    Topics: Alcohol Drinking; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Depressants; Compulsive Behavior; Conditioning, Operant; Disease Models, Animal; Ethanol; Glutamate Decarboxylase; Male; Nicotine; Nicotinic Agonists; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-fos; Quinine; Rats; Rats, Wistar; Reward; Self Administration; Time Factors

2015
Involvement of the rostral agranular insular cortex in nicotine self-administration in rats.
    Behavioural brain research, 2015, Sep-01, Volume: 290

    Topics: Animals; Behavior, Animal; Cerebral Cortex; Cues; Disease Models, Animal; Feeding Behavior; GABA-B Receptor Agonists; Male; Nicotine; Rats; Rats, Long-Evans; Reinforcement, Psychology; Self Administration; Tobacco Use Disorder

2015
Adolescent alcohol exposure decreased sensitivity to nicotine in adult Wistar rats.
    Addiction biology, 2016, Volume: 21, Issue:4

    Topics: Alcohol Drinking; Animals; Central Nervous System Depressants; Conditioning, Classical; Disease Models, Animal; Ethanol; Male; Nicotine; Rats; Rats, Wistar

2016
Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat.
    Brain pathology (Zurich, Switzerland), 2016, Volume: 26, Issue:2

    Topics: Animals; Animals, Newborn; Antioxidants; Astrocytes; Body Weight; Disease Models, Animal; Docosahexaenoic Acids; Evoked Potentials, Auditory, Brain Stem; Gliosis; Hypoxia-Ischemia, Brain; Inferior Colliculi; Melatonin; Neurons; Neuroprotective Agents; Nicotine; Oligodendroglia; Organ Size; Random Allocation; Rats, Sprague-Dawley; Reactive Oxygen Species; Resveratrol; Stilbenes

2016
Nicotine-induced place conditioning and locomotor activity in an adolescent animal model of attention deficit/hyperactivity disorder (ADHD).
    Behavioural brain research, 2015, Sep-15, Volume: 291

    Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglionic Stimulants; Male; Motor Activity; Nicotine; Rats, Inbred SHR; Rats, Inbred WKY; Spatial Behavior; Species Specificity

2015
Effects of low-intensity pulsed ultrasound on spinal pseudarthrosis created by nicotine administration: a model of lumbar posterolateral pseudarthrosis in rabbits.
    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2015, Volume: 34, Issue:6

    Topics: Animals; Disease Models, Animal; Lumbar Vertebrae; Nicotine; Pseudarthrosis; Rabbits; Spinal Fractures; Ultrasonic Waves; Ultrasonography

2015
Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice.
    Neuropharmacology, 2015, Volume: 97

    Topics: Animals; Anxiety; Benzamides; Conditioning, Psychological; Disease Models, Animal; Hot Temperature; Hyperalgesia; Male; Mice, Inbred ICR; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Pyrrolidines; Receptors, Opioid, kappa; Spatial Behavior; Substance Withdrawal Syndrome; Tobacco Use Disorder

2015
Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor.
    Neuroscience research, 2015, Volume: 100

    Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Frontal Lobe; Male; Mutation, Missense; Nicotine; Protein Subunits; Rats; Rats, Transgenic; Receptors, Nicotinic; Sensorimotor Cortex

2015
Cholinergic anti-inflammatory pathway in the non-obese diabetic mouse model.
    Oral diseases, 2015, Volume: 21, Issue:7

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged-Ring Compounds; Chemokine CCL2; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Inflammation; Islets of Langerhans; Mice; Mice, Inbred NOD; Nicotine; Pancreatitis; Saliva; Salivary Glands; Salivation; Sjogren's Syndrome; Spiro Compounds; Tumor Necrosis Factor-alpha; Vagotomy

2015
Effects of nicotine on a rat model of early stage osteoarthritis.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:4

    Topics: Animals; Cartilage Diseases; Cartilage, Articular; Disease Models, Animal; Femur; Humans; Immobilization; Inflammation; Male; Nicotine; Osteoarthritis; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Synovial Membrane; Tumor Necrosis Factor-alpha

2015
Prenatal Nicotine Exposure Impairs the Proliferation of Neuronal Progenitors, Leading to Fewer Glutamatergic Neurons in the Medial Prefrontal Cortex.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:2

    Topics: Animals; Cell Cycle; Cell Movement; Cognition Disorders; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Neurons; Nicotine; Nicotinic Agonists; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation

2016
Cigarette smoke exposure during adolescence enhances sensitivity to the rewarding effects of nicotine in adulthood, even after a long period of abstinence.
    Neuropharmacology, 2015, Volume: 99

    Topics: Aging; Animals; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Motivation; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Reward; Self Administration; Spatial Behavior; Tobacco Smoke Pollution; Tobacco Use Disorder

2015
Different physiological and behavioural effects of e-cigarette vapour and cigarette smoke in mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:10

    Topics: Animals; Body Weight; Brain; Cotinine; Disease Models, Animal; Eating; Electronic Nicotine Delivery Systems; Emotions; Male; Mecamylamine; Memory, Short-Term; Mice, Inbred BALB C; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Respiration, Artificial; Spatial Memory; Substance Withdrawal Syndrome; Tobacco Smoke Pollution; Tobacco Use Disorder

2015
Nicotine Induces Tumor Growth and Chemoresistance through Activation of the PI3K/Akt/mTOR Pathway in Bladder Cancer.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:9

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; Mice; Nicotine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Burden; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2015
Prenatal stress induces vulnerability to nicotine addiction and alters D2 receptors' expression in the nucleus accumbens in adult rats.
    Neuroscience, 2015, Sep-24, Volume: 304

    Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Female; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Polymerase Chain Reaction; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Receptors, Dopamine D2; RNA, Messenger; Spatial Behavior; Stress, Psychological; Tobacco Use Disorder

2015
Striatal NOS1 has dimorphic expression and activity under stress and nicotine sensitization.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:10

    Topics: Animals; Caudate Nucleus; Disease Models, Animal; Female; Isoenzymes; Male; Mice, 129 Strain; Mice, Knockout; Neurons; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitric Oxide Synthase Type I; Nucleus Accumbens; Putamen; Sex Characteristics; Stress, Psychological; Tobacco Use Disorder

2015
Acute Exposure to Electronic and Combustible Cigarette Aerosols: Effects in an Animal Model and in Human Alveolar Cells.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016, Volume: 18, Issue:5

    Topics: Aerosols; Albumins; Animals; Bronchoalveolar Lavage Fluid; Cell Culture Techniques; Cell Death; Disease Models, Animal; Electronic Nicotine Delivery Systems; Humans; Inflammation; Lung; Male; Mice, Inbred C57BL; Nicotiana; Nicotine; Oxidative Stress; Pulmonary Alveoli; Smoking

2016
Modulation of social deficits and repetitive behaviors in a mouse model of autism: the role of the nicotinic cholinergic system.
    Psychopharmacology, 2015, Volume: 232, Issue:23

    Topics: Animals; Autistic Disorder; Cholinergic Agents; Cholinergic Neurons; Cotinine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Interpersonal Relations; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Nicotine

2015
Effects of varenicline on operant self-administration of alcohol and/or nicotine in a rat model of co-abuse.
    Behavioural brain research, 2016, Jan-01, Volume: 296

    Topics: Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Drug Interactions; Ethanol; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Substance-Related Disorders; Varenicline

2016
Rats quit nicotine for a sweet reward following an extensive history of nicotine use.
    Addiction biology, 2017, Volume: 22, Issue:1

    Topics: Animals; Behavior, Addictive; Behavior, Animal; Choice Behavior; Disease Models, Animal; Male; Nicotine; Rats; Rats, Sprague-Dawley; Reward; Saccharin; Sweetening Agents

2017
Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.
    Stroke, 2015, Volume: 46, Issue:11

    Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Heart Rate; Immunity, Innate; Infarction, Middle Cerebral Artery; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Parasympathetic Nervous System; Parasympathomimetics; Pneumonia; Receptors, Nicotinic; Respiratory Mucosa; Signal Transduction; Stroke; Vagotomy

2015
Effects of the phencyclidine model of schizophrenia and nicotine on total and categorized ultrasonic vocalizations in rats.
    Behavioural pharmacology, 2016, Volume: 27, Issue:4

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hallucinogens; Male; Nicotine; Phencyclidine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Schizophrenia; Smoking; Ultrasonics; Vocalization, Animal

2016
Locomotor response to acute nicotine in adolescent mice is altered by maternal undernutrition during lactation.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2015, Volume: 47, Issue:Pt B

    Topics: Adrenal Medulla; Animals; Animals, Newborn; Body Mass Index; Caloric Restriction; Catecholamines; Diet, Protein-Restricted; Disease Models, Animal; Eating; Exploratory Behavior; Fats; Female; Hormones; Lactation; Leptin; Locomotion; Male; Malnutrition; Mice; Nicotine; Nicotinic Agonists

2015
Endogenous Acetylcholine Controls the Severity of Polymicrobial Sepsisassociated Inflammatory Response in Mice.
    Current neurovascular research, 2016, Volume: 13, Issue:1

    Topics: Acetylcholine; Analysis of Variance; Animals; Cell Movement; Chemokine CXCL12; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Bacterial; Ligation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neutrophils; Nicotine; Nicotinic Agonists; Peritoneal Cavity; Sepsis; Tumor Necrosis Factor-alpha; Typhlitis; Vesicular Acetylcholine Transport Proteins

2016
Effects of conventional tobacco smoke and nicotine-free cigarette smoke on airway inflammation, airway remodelling and lung function in a triple allergen model of severe asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2016, Volume: 46, Issue:7

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Female; Humans; Immunoglobulin E; Immunoglobulin G; Immunomodulation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nicotine; Respiratory Function Tests; Respiratory Tract Diseases; Signal Transduction; Smoking; Spleen; Th2 Cells; Toll-Like Receptor 4

2016
Investigation of the protective effect of ellagic acid for preventing kidney injury in rats exposed to nicotine during the fetal period.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2016, Volume: 91, Issue:2

    Topics: Acute Kidney Injury; Animals; Antioxidants; Disease Models, Animal; Ellagic Acid; Female; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Male; Malondialdehyde; Nicotine; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley

2016
Coronary angiogenesis during morphine and nicotine withdrawal in two-kidney one clip hypertensive (2K1C) rats.
    Bratislavske lekarske listy, 2015, Volume: 116, Issue:9

    Topics: Analgesics, Opioid; Animals; Blood Pressure; Cardiovascular System; Disease Models, Animal; Heart; Heart Rate; Hypertension, Renovascular; Male; Morphine; Morphine Dependence; Neovascularization, Physiologic; Nicotine; Nicotinic Agonists; Nitric Oxide; Rats; Rats, Wistar; Renal Artery; Substance Withdrawal Syndrome; Surgical Instruments; Tobacco Use Disorder

2015
Chronic nicotine exposure exacerbates transient focal cerebral ischemia-induced brain injury.
    Journal of applied physiology (Bethesda, Md. : 1985), 2016, Feb-01, Volume: 120, Issue:3

    Topics: Animals; Antioxidants; Brain Injuries; Cerebral Arteries; Disease Models, Animal; Infarction, Middle Cerebral Artery; Ion Channels; Ischemic Attack, Transient; Male; Mitochondrial Proteins; NADPH Oxidases; Nicotine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke; Superoxide Dismutase; Superoxides; Uncoupling Protein 2

2016
Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Apr-01, Volume: 22, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Hepatocyte Growth Factor; Humans; Inhibitor of Differentiation Protein 1; Mice; Neoplasm Metastasis; Nicotine; Pancreatic Neoplasms; Paracrine Communication; Phosphorylation; Proto-Oncogene Proteins c-met; Signal Transduction; Smoking; Tumor Microenvironment; Xenograft Model Antitumor Assays

2016
Prenatal cigarette smoke exposure effects on apoptotic and nicotinic acetylcholine receptor expression in the infant mouse brainstem.
    Neurotoxicology, 2016, Volume: 53

    Topics: Analysis of Variance; Animals; Apoptosis; Brain Stem; Caspase 3; Disease Models, Animal; Female; Gene Expression Regulation, Developmental; In Situ Nick-End Labeling; Male; Mice; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Protein Subunits; Receptors, Nicotinic; Smoking

2016
Developmental nicotine exposure disrupts dendritic arborization patterns of hypoglossal motoneurons in the neonatal rat.
    Developmental neurobiology, 2016, Volume: 76, Issue:10

    Topics: Animals; Animals, Newborn; Brain Stem; Dendrites; Disease Models, Animal; Female; Hypoglossal Nerve; Motor Neurons; Neuroanatomical Tract-Tracing Techniques; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Synaptic Transmission; Tissue Culture Techniques

2016
Developmental nicotine exposure alters cholinergic control of respiratory frequency in neonatal rats.
    Developmental neurobiology, 2016, Volume: 76, Issue:10

    Topics: Acetylcholine; Animals; Animals, Newborn; Atropine; Brain Stem; Cholinergic Agonists; Curare; Disease Models, Animal; Female; Membrane Potentials; Motor Neurons; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phrenic Nerve; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Respiration; Spinal Cord; Tissue Culture Techniques

2016
Nicotine Enhances High-Fat Diet-Induced Oxidative Stress in the Kidney.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016, Volume: 18, Issue:7

    Topics: Animals; Biomarkers; Diet, High-Fat; Disease Models, Animal; Kidney; Male; Mice; Mice, Inbred C57BL; Nicotine; Obesity; Oxidative Stress; Reactive Oxygen Species; Smoking

2016
Varenicline impairs extinction and enhances reinstatement across repeated cycles of nicotine self-administration in rats.
    Neuropharmacology, 2016, Volume: 105

    Topics: Animals; Catheters, Indwelling; Disease Models, Animal; Drug-Seeking Behavior; Extinction, Psychological; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Self Administration; Tobacco Use Cessation Devices; Tobacco Use Disorder; Varenicline

2016
Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats.
    Molecular medicine reports, 2016, Volume: 13, Issue:4

    Topics: Animals; Antioxidants; Biomarkers; Blood Chemical Analysis; Connexins; Curcumin; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Male; Nicotine; Oxidative Stress; Podocytes; Rats; Transcriptome

2016
Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Animals; Aorta; Cholecalciferol; Disease Models, Animal; Endoplasmic Reticulum Stress; Hydrogen Sulfide; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nicotine; Rats; Rats, Sprague-Dawley; Vascular Calcification

2016
Expression profile of nicotinic acetylcholine receptor subunits in the brain of HIV-1 transgenic rats given chronic nicotine treatment.
    Journal of neurovirology, 2016, Volume: 22, Issue:5

    Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Gene Expression Regulation; HIV Infections; HIV-1; Male; Nicotine; Nucleus Accumbens; Protein Subunits; Rats; Rats, Inbred F344; Rats, Transgenic; Receptors, Nicotinic; RNA, Messenger; Signal Transduction; Tobacco Use Disorder; Ventral Tegmental Area

2016
Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline.
    Behavioural brain research, 2016, 07-15, Volume: 308

    Topics: Animals; Disease Models, Animal; Drug Combinations; Drug-Seeking Behavior; Extinction, Psychological; Female; Male; Nicotine; Nicotinic Agonists; Progesterone; Progestins; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration; Sex Factors; Smoking Cessation; Varenicline

2016
Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor.
    Brain research, 2016, 07-01, Volume: 1642

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Blood Pressure; CA1 Region, Hippocampal; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Eclampsia; Female; Lipopolysaccharides; Microglia; Neuroimmunomodulation; Neurons; Nicotine; Nicotinic Agonists; Pentylenetetrazole; Pregnancy; Pregnancy Outcome; Random Allocation; Rats, Sprague-Dawley; Seizures

2016
Synthesis, Nicotinic Acetylcholine Binding, and in Vitro and in Vivo Pharmacological Properties of 2'-Fluoro-(carbamoylpyridinyl)deschloroepibatidine Analogues.
    ACS chemical neuroscience, 2016, 07-20, Volume: 7, Issue:7

    Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hyperalgesia; Locomotion; Mice; Molecular Structure; Nicotine; Protein Binding; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Tritium; Xenopus laevis

2016
The Effects of Cigarette Smoke Condensate and Nicotine on Periodontal Tissue in a Periodontitis Model Mouse.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Mice; Mice, Inbred C57BL; Nicotine; Osteoclasts; Osteogenesis; Periodontal Diseases; Periodontium; RANK Ligand; Real-Time Polymerase Chain Reaction; Smoking; Tartrate-Resistant Acid Phosphatase; X-Ray Microtomography

2016
Nicotine effects on muscarinic receptor-mediated free Ca[Formula: see text] level changes in the facial nucleus following facial nerve injury.
    Journal of integrative neuroscience, 2016, Volume: 15, Issue:2

    Topics: Animals; Calcium; Cations, Divalent; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Facial Nerve Injuries; Facial Nucleus; Female; Male; Nerve Regeneration; Nicotine; Nicotinic Agonists; Random Allocation; Rats, Sprague-Dawley; Receptors, Muscarinic; Tissue Culture Techniques

2016
Nicotine-induced behavioral sensitization in an adult rat model of attention deficit/hyperactivity disorder (ADHD).
    Behavioural brain research, 2016, 10-01, Volume: 312

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Models, Animal; Locomotion; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2016
Temporal Rewiring of Striatal Circuits Initiated by Nicotine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:13

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Goals; In Vitro Techniques; Locomotion; Male; Microdialysis; Nerve Net; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Dopamine; RNA, Messenger; Silver Staining; Statistics, Nonparametric; Time Factors; Tobacco Use Disorder

2016
Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:9

    Topics: Animals; Anxiety; Corticotropin-Releasing Hormone; Dependovirus; Disease Models, Animal; Genetic Vectors; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Receptors, Nicotinic; Reward; Self Stimulation; Septal Nuclei; Substance Withdrawal Syndrome; Tobacco Use Disorder

2016
Nicotine produces long-term increases in cocaine reinforcement in adolescent but not adult rats.
    Brain research, 2017, 01-01, Volume: 1654, Issue:Pt B

    Topics: Aging; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Synergism; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Sexual Maturation; Time Factors; Tobacco Use Disorder

2017
Individual Variations in the Mechanisms of Nicotine Seeking: A Key for Research on Nicotine Dependence.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:3

    Topics: Animals; Disease Models, Animal; Drug-Seeking Behavior; Humans; Nicotine; Nicotinic Agonists; Tobacco Use Disorder

2017
Protective Effect of Nicotine on Sepsis-Induced Oxidative Multiorgan Damage: Role of Neutrophils.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2017, Jul-01, Volume: 19, Issue:7

    Topics: Animals; Disease Models, Animal; Lipid Peroxidation; Male; Neutrophils; Nicotine; Rats; Rats, Wistar; Sepsis

2017
Altered nocifensive behavior in animal models of autism spectrum disorder: The role of the nicotinic cholinergic system.
    Neuropharmacology, 2016, Volume: 111

    Topics: Animals; Autism Spectrum Disorder; Avoidance Learning; Brain; Disease Models, Animal; Female; Fragile X Mental Retardation Protein; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Nociception; Protein Subunits; Receptors, Nicotinic

2016
Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats.
    Psychopharmacology, 2016, Volume: 233, Issue:23-24

    Topics: Acetylcysteine; Animals; Animals, Newborn; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Drug-Seeking Behavior; Free Radical Scavengers; Hippocampus; Male; Memory Disorders; Memory, Short-Term; Nicotine; Nicotinic Agonists; Prefrontal Cortex; Rats; Rats, Sprague-Dawley

2016
Cigarette smoke exposure during adolescence but not adulthood induces anxiety-like behavior and locomotor stimulation in rats during withdrawal.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2016, Volume: 55

    Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Avoidance Learning; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Tobacco Use Disorder

2016
Striatal cholinergic interneurons and D2 receptor-expressing GABAergic medium spiny neurons regulate tardive dyskinesia.
    Experimental neurology, 2016, Volume: 286

    Topics: Animals; Antipsychotic Agents; Channelrhodopsins; Choline O-Acetyltransferase; Cholinergic Neurons; Corpus Striatum; Disease Models, Animal; GABAergic Neurons; Gene Expression Regulation; Haloperidol; Male; Mastication; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Dopamine D2; Tardive Dyskinesia

2016
Impaired function of α2-containing nicotinic acetylcholine receptors on oriens-lacunosum moleculare cells causes hippocampus-dependent memory impairments.
    Neurobiology of learning and memory, 2016, Volume: 136

    Topics: Animals; Animals, Newborn; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, Animal; Female; Interneurons; Long-Term Potentiation; Memory Disorders; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Nicotinic; Recognition, Psychology; Spatial Memory

2016
Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice.
    Brain research, 2016, 12-01, Volume: 1652

    Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Drug Evaluation, Preclinical; Hypothalamo-Hypophyseal System; Infusions, Intraventricular; Male; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Pituitary-Adrenal System; Psychotropic Drugs; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome; Tobacco Use Disorder; Urocortins

2016
Nicotine protects against DSS colitis through regulating microRNA-124 and STAT3.
    Journal of molecular medicine (Berlin, Germany), 2017, Volume: 95, Issue:2

    Topics: Animals; Caco-2 Cells; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Epithelial Cells; Humans; Jurkat Cells; Mice; Mice, Inbred C57BL; MicroRNAs; Nicotine; STAT3 Transcription Factor; Statistics, Nonparametric; T-Lymphocytes; Up-Regulation

2017
[Nicotine alleviates the liver inflammation of non-alcoholic steatohepatitis induced by high-fat and high-fructose in mice].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2016, 10-18, Volume: 48, Issue:5

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Diet, Carbohydrate Loading; Diet, High-Fat; Dietary Fats; Disease Models, Animal; Down-Regulation; Fructose; Inflammation; Interleukin-6; Kupffer Cells; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nicotine; Non-alcoholic Fatty Liver Disease; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2016
Alpha-7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2016, Volume: 76, Issue:6

    Topics: Aconitine; Adult; alpha7 Nicotinic Acetylcholine Receptor; Animals; Ascitic Fluid; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Endometriosis; Endometrium; Female; Gene Expression Regulation; Humans; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mice; Nicotine; Primary Cell Culture; Quinuclidines; RNA, Messenger; Severity of Illness Index; Signal Transduction

2016
Protein phosphatase Mg2+/Mn2+ dependent 1F promotes smoking-induced breast cancer by inactivating phosphorylated-p53-induced signals.
    Oncotarget, 2016, Nov-22, Volume: 7, Issue:47

    Topics: Adult; Aged; Animals; bcl-2-Associated X Protein; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Combined Modality Therapy; Disease Models, Animal; Female; Gene Expression; Gene Knockdown Techniques; Humans; Mice; Middle Aged; Models, Biological; Neoplasm Staging; Nicotine; Phosphoprotein Phosphatases; Phosphorylation; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Smoking; Tumor Suppressor Protein p53

2016
Nicotine Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells.
    Arteriosclerosis, thrombosis, and vascular biology, 2017, Volume: 37, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Aorta, Thoracic; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Bone Marrow Transplantation; Cell Degranulation; Cells, Cultured; Cholesterol; Collagen; Diet, High-Fat; Disease Models, Animal; Disease Progression; Foam Cells; Genetic Predisposition to Disease; Macrophages, Peritoneal; Male; Mast Cells; Mice, Knockout; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenotype; Plaque, Atherosclerotic; Proto-Oncogene Proteins c-kit; Signal Transduction; Time Factors

2017
Activation of the cholinergic anti-inflammatory system by nicotine attenuates arthritis via suppression of macrophage migration.
    Molecular medicine reports, 2016, Volume: 14, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Biopsy; Cell Membrane; Cell Movement; Chemokine CCL2; Chemokines; Disease Models, Animal; Endothelial Cells; Immunophenotyping; Intercellular Adhesion Molecule-1; Macrophages; Male; Mice; Nicotine; Phenotype; Spleen; Synovial Membrane

2016
An animal model of effects of nicotine exposure on endometrial receptivity and embryo implantation in pregnancy.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2017, Volume: 30, Issue:23

    Topics: Animals; Disease Models, Animal; Embryo Implantation; Endometrium; Female; Humans; Male; Maternal Exposure; Nicotine; Pregnancy; Pregnancy Complications; Rats; Toxicity Tests, Chronic

2017
Ghrelin improves vascular autophagy in rats with vascular calcification.
    Life sciences, 2017, Jun-15, Volume: 179

    Topics: AMP-Activated Protein Kinases; Animals; Aorta; Autophagy; Calcium; Cholecalciferol; Disease Models, Animal; Ghrelin; Glycerophosphates; Male; Muscle, Smooth, Vascular; Nicotine; Rats; Rats, Sprague-Dawley; Vascular Calcification

2017
Activation of the cholinergic anti-inflammatory pathway by nicotine ameliorates lipopolysaccharide-induced preeclampsia-like symptoms in pregnant rats.
    Placenta, 2017, Volume: 49

    Topics: Animals; Anti-Inflammatory Agents; Bungarotoxins; Cytokines; Disease Models, Animal; Female; Lipopolysaccharides; NF-kappa B; Nicotine; Placenta; Pre-Eclampsia; Pregnancy; Rats; Receptors, Nicotinic; Signal Transduction

2017
Cortical hemorrhage-associated neurological deficits and tissue damage in mice are ameliorated by therapeutic treatment with nicotine.
    Journal of neuroscience research, 2017, Volume: 95, Issue:9

    Topics: Animals; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Ganglionic Stimulants; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nicotine; Parietal Lobe; Recovery of Function

2017
Smoking activates cytotoxic CD8
    Journal of autoimmunity, 2017, Volume: 78

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arthritis, Rheumatoid; Biomarkers; Bone Marrow; Case-Control Studies; Child; Child, Preschool; Disease Models, Animal; Female; Humans; Immunophenotyping; Inhibitor of Apoptosis Proteins; Lymphocyte Activation; Male; Mice; Mice, Knockout; Middle Aged; Nicotine; Phenotype; Programmed Cell Death 1 Receptor; Smoking; Survivin; T-Lymphocytes, Cytotoxic; Young Adult

2017
Nicotine reverses hypofrontality in animal models of addiction and schizophrenia.
    Nature medicine, 2017, Volume: 23, Issue:3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; CRISPR-Cas Systems; Disease Models, Animal; Fluorescent Antibody Technique; Male; Mice; Mice, Knockout; Mice, Transgenic; Neural Inhibition; Nicotine; Nicotinic Agonists; Polymorphism, Single Nucleotide; Prefrontal Cortex; Prepulse Inhibition; Pyramidal Cells; Receptors, Adrenergic, beta-2; Receptors, Nicotinic; Reflex, Startle; Schizophrenia; Social Behavior; Tobacco Use Disorder

2017
Self-administered nicotine differentially impacts body weight gain in obesity-prone and obesity-resistant rats.
    Physiology & behavior, 2017, Jul-01, Volume: 176

    Topics: Analysis of Variance; Animals; Body Weight; Conditioning, Operant; Dietary Fats; Disease Models, Animal; Eating; Feeding Behavior; Male; Nicotine; Nicotinic Agonists; Obesity; Rats; Rats, Sprague-Dawley; Self Administration

2017
The effects of nicotine in the neonatal quinpirole rodent model of psychosis: Neural plasticity mechanisms and nicotinic receptor changes.
    Behavioural brain research, 2017, 05-15, Volume: 325, Issue:Pt A

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain-Derived Neurotrophic Factor; Corpus Striatum; Disease Models, Animal; Female; Male; Motor Activity; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Psychotic Disorders; Quinpirole; Rats, Sprague-Dawley; Receptors, Nicotinic

2017
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 03-14, Volume: 114, Issue:11

    Topics: Aged; Aged, 80 and over; alpha-Synuclein; Animals; Basal Ganglia; Biomarkers; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; Gene Deletion; Gene Expression; Humans; Locomotion; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Mice, Transgenic; Middle Aged; Nerve Tissue Proteins; Nicotine; Parkinson Disease; Protein Binding; Synaptic Vesicles

2017
Roselle supplementation prevents nicotine-induced vascular endothelial dysfunction and remodelling in rats.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2017, Volume: 42, Issue:7

    Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Disease Models, Animal; Endothelium, Vascular; Hibiscus; Male; Nicotine; Oxidative Stress; Phenylephrine; Phytotherapy; Plant Preparations; Rats; Rats, Sprague-Dawley; Vascular Diseases; Vasoconstriction; Vasodilator Agents

2017
Electronic Cigarettes Are as Toxic to Skin Flap Survival as Tobacco Cigarettes.
    Annals of plastic surgery, 2017, Volume: 79, Issue:1

    Topics: Animals; Disease Models, Animal; Electronic Nicotine Delivery Systems; Graft Survival; Male; Myocutaneous Flap; Nicotine; Random Allocation; Rats; Rats, Sprague-Dawley; Surgical Flaps; Tobacco Smoke Pollution

2017
In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence.
    Neuropharmacology, 2017, 05-15, Volume: 118

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Local; Animals; Benzamides; Bridged Bicyclo Compounds; Cocaine; Conditioning, Operant; Disease Models, Animal; Fenofibrate; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Oxazoles; PPAR alpha; Pyrimidines; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine

2017
The effects of nicotine administration on the pathophysiology of rat aortic wall.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2017, Volume: 92, Issue:2

    Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Collagen; Disease Models, Animal; Male; Matrix Metalloproteinases; Nicotine; Rats, Sprague-Dawley

2017
Spinal microglial P2X4 receptor-brain-derived neurotrophic factor signaling regulates nicotine withdrawal-induced hyperalgesia.
    Neuroreport, 2017, Apr-12, Volume: 28, Issue:6

    Topics: Analgesics, Non-Narcotic; Animals; Brain-Derived Neurotrophic Factor; Calcium-Binding Proteins; Disease Models, Animal; Hot Temperature; Hyperalgesia; Male; Microfilament Proteins; Microglia; Minocycline; Nicotine; Nicotinic Agonists; Pain Threshold; Rats, Sprague-Dawley; Receptors, Purinergic P2X4; Spinal Cord; Substance Withdrawal Syndrome

2017
Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression.
    Brain research bulletin, 2008, Sep-05, Volume: 77, Issue:1

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug Administration Schedule; Exploratory Behavior; Injections, Intraperitoneal; Male; Motor Activity; Nicotine; Olfactory Bulb; Psychology, Comparative; Rats; Rats, Long-Evans; Rats, Wistar; Self Administration; Species Specificity; Swimming; Transcranial Magnetic Stimulation

2008
In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives: implications for Parkinson's Disease.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Alkaloids; Animals; Antiparkinson Agents; Azocines; Bridged-Ring Compounds; Disease Models, Animal; Dopamine; Male; Microdialysis; Neostriatum; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Oxidopamine; Parkinsonian Disorders; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Substantia Nigra

2008
Chronic nicotine exposure has dissociable behavioural effects on control and beta2-/- mice.
    Behavior genetics, 2008, Volume: 38, Issue:5

    Topics: Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Receptors, Nicotinic; Social Behavior; Time Factors

2008
Nicotine administration and withdrawal affect survival in systemic inflammation models.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:4

    Topics: Animals; Body Temperature; Cecum; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Infusion Pumps, Implantable; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Sepsis; Substance Withdrawal Syndrome; Systemic Inflammatory Response Syndrome; Time Factors; Tobacco Use Disorder

2008
Continuous and intermittent nicotine treatment reduces L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias in a rat model of Parkinson's disease.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:1

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Infusion Pumps; Levodopa; Male; Nicotine; Parkinson Disease; Rats; Rats, Sprague-Dawley

2008
Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice.
    Journal of biomedical science, 2008, Volume: 15, Issue:6

    Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Fructose; Ganglionic Stimulants; Male; Mice; Nicotine; Pentylenetetrazole; Seizures; Topiramate; Valproic Acid

2008
The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish.
    Physiology & behavior, 2008, Oct-20, Volume: 95, Issue:3

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Dihydro-beta-Erythroidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Immobility Response, Tonic; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Swimming; Zebrafish; Zebrafish Proteins

2008
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2008, Volume: 60, Issue:6

    Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Injections, Subcutaneous; Necrosis; Nicotine; Nicotinic Agonists; Rats; Skin; Surgical Flaps; Tissue Survival; Withholding Treatment

2008
[Pathophysiological aspects of smoking in pregnancy].
    Zeitschrift fur Geburtshilfe und Neonatologie, 2008, Volume: 212, Issue:3

    Topics: Animals; Carbon Dioxide; Disease Models, Animal; Endothelium, Vascular; Female; Fetal Development; Fetal Growth Retardation; Humans; Infant, Newborn; Maternal-Fetal Exchange; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Smoking; Smoking Cessation; Vascular Resistance

2008
How do we solve the puzzle of unintended consequences of inflammation? Systematically.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:4

    Topics: Animals; Biomedical Research; Body Temperature; Cecum; Disease Models, Animal; Disease Progression; Humans; Lipopolysaccharides; Nicotine; Nicotinic Agonists; Research Design; Sepsis; Substance Withdrawal Syndrome; Systemic Inflammatory Response Syndrome; Tobacco Use Disorder

2008
New operant model of nicotine-seeking behaviour in mice.
    The international journal of neuropsychopharmacology, 2009, Volume: 12, Issue:3

    Topics: Analysis of Variance; Animals; Chi-Square Distribution; Conditioning, Operant; Cues; Disease Models, Animal; Extinction, Psychological; Male; Mice; Mice, Inbred C57BL; Nicotine; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Tobacco Use Disorder

2009
Relationship between arterial calcification and bone loss in a new combined model rat by ovariectomy and vitamin D(3) plus nicotine.
    Calcified tissue international, 2008, Volume: 83, Issue:3

    Topics: Animals; Arteries; Calcinosis; Calcium; Cholecalciferol; Disease Models, Animal; Endothelin-1; Estradiol; Female; Femur; Nicotine; Nitric Oxide Synthase Type III; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Tibia

2008
Effects of nicotine infusion on striatal glutamate and cortical non-protein-bound iron in hypoxic newborn piglets.
    Neonatology, 2008, Volume: 94, Issue:4

    Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Corpus Striatum; Disease Models, Animal; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Iron; Neuroprotective Agents; Nicotine; Random Allocation; Swine

2008
Nicotine, but not mecamylamine, enhances antidepressant-like effects of citalopram and reboxetine in the mouse forced swim and tail suspension tests.
    Behavioural brain research, 2009, Jan-30, Volume: 197, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Mecamylamine; Mice; Morpholines; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Reboxetine; Receptors, Nicotinic; Selective Serotonin Reuptake Inhibitors; Serotonin

2009
The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.
    Neuropharmacology, 2009, Volume: 56, Issue:1

    Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Carbamates; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Epilepsy; Evoked Potentials, Auditory; Exploratory Behavior; Hippocampus; Male; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Agonists; Pain; Pain Threshold; Quinuclidines; Rats; Receptors, Nicotinic; Sensory Gating; Social Behavior; Time Factors

2009
Propranolol transiently inhibits reinstatement of nicotine-seeking behaviour in rats.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Behavior, Addictive; Disease Models, Animal; Extinction, Psychological; Feeding Behavior; Male; Nicotine; Nicotinic Agonists; Propranolol; Rats; Rats, Sprague-Dawley; Reward; Secondary Prevention; Self Administration; Smoking; Smoking Prevention

2010
Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism.
    Progress in neuro-psychopharmacology & biological psychiatry, 2009, Apr-30, Volume: 33, Issue:3

    Topics: Alcoholism; Alkaloids; Analysis of Variance; Animals; Antidepressive Agents; Azocines; Depression; Disease Models, Animal; Drug Administration Schedule; Male; Nicotine; Protein Binding; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Swimming; Tritium

2009
Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model.
    Neuroscience research, 2008, Volume: 62, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Electron Spin Resonance Spectroscopy; Functional Laterality; Galantamine; Gene Expression Regulation; Male; Mecamylamine; Methamphetamine; Motor Activity; Neuroprotective Agents; Nicotine; Nicotinic Antagonists; Parkinsonian Disorders; Rats; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger; Rotarod Performance Test; Tyrosine 3-Monooxygenase

2008
Nicotine augments glomerular injury in a rat model of acute nephritis.
    American journal of nephrology, 2009, Volume: 29, Issue:4

    Topics: Acute Disease; Animals; Cell Count; Cell Division; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Fibronectins; Glomerulonephritis; Isoantibodies; Mesangial Cells; Nicotine; Nicotinic Agonists; Prostaglandins; Rats; Rats, Sprague-Dawley; Smoking

2009
Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal cord injury.
    Journal of neuroscience research, 2009, Volume: 87, Issue:4

    Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Injections, Intraperitoneal; Male; Microglia; Neuroprotective Agents; Nicotine; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Long-Evans; RNA, Messenger; Spinal Cord; Spinal Cord Injuries; Tyrosine

2009
Perinatal nicotine exposure alters AT 1 and AT 2 receptor expression pattern in the brain of fetal and offspring rats.
    Brain research, 2008, Dec-03, Volume: 1243

    Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Down-Regulation; Female; Gene Expression Regulation, Developmental; Male; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Sex Characteristics; Smoking; Up-Regulation

2008
Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis.
    Journal of periodontal research, 2009, Volume: 44, Issue:1

    Topics: Alveolar Bone Loss; Animals; Corticosterone; Disease Models, Animal; Disease Susceptibility; Escherichia coli; Injections, Intraperitoneal; Injections, Subcutaneous; Interleukin-10; Lipopolysaccharides; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Periodontitis; Rats; Rats, Inbred F344; Receptors, Nicotinic; Sodium Chloride; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2009
The role of nicotine in smoking: a dual-reinforcement model.
    Nebraska Symposium on Motivation. Nebraska Symposium on Motivation, 2009, Volume: 55

    Topics: Animals; Association Learning; Conditioning, Psychological; Cues; Disease Models, Animal; Ganglionic Stimulants; Humans; Motivation; Nicotine; Rats; Reward; Self Administration; Smoking; Smoking Cessation; Social Environment; Substance Withdrawal Syndrome; Tobacco Use Disorder

2009
Nicotine (NC)-induced "depressive" behavioral symptoms and effects of antidepressants including cannabinoids (CBs).
    The Journal of toxicological sciences, 2008, Volume: 33, Issue:5

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Cannabinoids; Data Interpretation, Statistical; Depression; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Nicotine; Restraint, Physical; Stress, Psychological; Swimming; Time Factors

2008
The dendritically targeted protein Dendrin is induced by acute nicotine in cortical regions of adolescent rat brain.
    The European journal of neuroscience, 2008, Volume: 28, Issue:10

    Topics: Age Factors; Aging; Animals; Cerebral Cortex; Cytoskeleton; Dendrites; Disease Models, Animal; Environment, Controlled; Exploratory Behavior; Male; Nerve Tissue Proteins; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Tobacco Use Disorder

2008
Prenatal to early postnatal nicotine exposure impairs central chemoreception and modifies breathing pattern in mouse neonates: a probable link to sudden infant death syndrome.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Dec-17, Volume: 28, Issue:51

    Topics: Animals; Animals, Newborn; Brain Stem; Carbon Dioxide; Chemoreceptor Cells; Disease Models, Animal; Drug Administration Schedule; Female; Humans; Hypercapnia; Hypoxia; Infant; Litter Size; Mice; Neurons; Nicotine; Nicotinic Agonists; Organ Culture Techniques; Periodicity; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Muscarinic; Receptors, Nicotinic; Respiration; Spinal Cord; Sudden Infant Death; Time Factors

2008
Nicotine does not improve recovery from learned nonuse nor enhance constraint-induced therapy after motor cortex stroke in the rat.
    Behavioural brain research, 2009, Mar-17, Volume: 198, Issue:2

    Topics: Administration, Oral; Animals; Brain; Disease Models, Animal; Exercise Therapy; Female; Functional Laterality; Injections, Subcutaneous; Motor Activity; Motor Cortex; Motor Skills; Nicotine; Nicotinic Agonists; Pilot Projects; Rats; Rats, Long-Evans; Recovery of Function; Stroke; Stroke Rehabilitation; Time Factors; Treatment Outcome

2009
Effects of diabetes and elevated glucose on nitrergic relaxations in the isolated duodenum of the rat.
    Acta diabetologica, 2009, Volume: 46, Issue:4

    Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Duodenum; Electric Stimulation; Glucose; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nicotine; Nitrergic Neurons; Rats; Rats, Wistar

2009
Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.
    Arthritis and rheumatism, 2009, Volume: 60, Issue:1

    Topics: Administration, Oral; alpha7 Nicotinic Acetylcholine Receptor; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bridged-Ring Compounds; Cartilage; Disease Models, Animal; Injections, Intraperitoneal; Macrophages; Male; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Agonists; Parasympathetic Nervous System; Receptors, Nicotinic; Spiro Compounds; Synovial Membrane; Synovitis; Tumor Necrosis Factor-alpha; Vagus Nerve

2009
Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:7

    Topics: Amygdala; Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mecamylamine; Mood Disorders; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome

2009
Nicotine withdrawal-induced deficits in trace fear conditioning in C57BL/6 mice--a role for high-affinity beta2 subunit-containing nicotinic acetylcholine receptors.
    The European journal of neuroscience, 2009, Volume: 29, Issue:2

    Topics: Animals; Avoidance Learning; Conditioning, Psychological; Disease Models, Animal; Drug Administration Schedule; Fear; Male; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tobacco Use Disorder

2009
Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys.
    Journal of neurochemistry, 2009, Volume: 109, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Analysis of Variance; Animals; Autoradiography; Cocaine; Conotoxins; Corpus Striatum; Cotinine; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Iodine Isotopes; Male; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotine; Oxidopamine; Protein Binding; Rats; Rats, Sprague-Dawley; Saimiri; Substantia Nigra; Time Factors

2009
Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:7

    Topics: Animals; Baclofen; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Drug Administration Schedule; Extinction, Psychological; GABA Agonists; Male; Mice; Mice, Inbred C57BL; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Tobacco Use Disorder

2009
Interaction between nicotinic and dopaminergic therapies on cognition in a chronic Parkinson model.
    Brain research, 2009, Mar-25, Volume: 1262

    Topics: Animals; Attention; Cognition; Cues; Discrimination Learning; Disease Models, Animal; Dopamine Agents; Drug Combinations; Drug Interactions; Injections, Intramuscular; Injections, Intravenous; Levodopa; Macaca mulatta; Male; Memory; MPTP Poisoning; Nicotine; Nicotinic Agonists; Phenols; Pyrrolidines; Reaction Time; Task Performance and Analysis

2009
Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 93, Issue:1

    Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Smoking; Smoking Prevention; Substance-Related Disorders

2009
Nicotine induces sensitization of turning behavior in 6-hydroxydopamine lesioned rats.
    Neurotoxicity research, 2009, Volume: 15, Issue:4

    Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Electrochemistry; Functional Laterality; Ganglionic Stimulants; Male; Nicotine; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Time Factors

2009
Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines.
    Cardiovascular research, 2009, Aug-01, Volume: 83, Issue:3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Atrial Fibrillation; Cardiac Pacing, Artificial; Cell Proliferation; Cells, Cultured; Collagen; Disease Models, Animal; Dogs; Down-Regulation; Female; Fibroblasts; Fibrosis; Heart Atria; Male; MicroRNAs; Nicotine; Nicotinic Antagonists; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Nicotinic; Receptors, Transforming Growth Factor beta; Transfection; Transforming Growth Factor beta1; Up-Regulation

2009
Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex.
    Behavioural pharmacology, 2009, Volume: 20, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Female; Hindlimb Suspension; Male; Mecamylamine; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Sex Factors; Species Specificity; Stress, Psychological

2009
Altered fast- and slow-twitch muscle fibre characteristics in female mice with a (S248F) knock-in mutation of the brain neuronal nicotinic acetylcholine receptor.
    Journal of muscle research and cell motility, 2009, Volume: 30, Issue:1-2

    Topics: Animals; Brain; Calcium; Disease Models, Animal; Dystonia; Female; Gene Knock-In Techniques; Hindlimb; Mice; Mice, Inbred C57BL; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Mutation, Missense; Myosin Heavy Chains; Nicotine; Protein Isoforms; Receptors, Nicotinic; Strontium

2009
Chronic nicotine exposure inhibits 17beta-estradiol-mediated protection of the hippocampal CA1 region against cerebral ischemia in female rats.
    Neuroscience letters, 2009, Jul-17, Volume: 458, Issue:2

    Topics: Animals; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation; Hippocampus; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Ovariectomy; Rats; Rats, Sprague-Dawley; Time Factors

2009
Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test.
    Psychopharmacology, 2009, Volume: 205, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nicotinic Agonists; Norepinephrine; Pyridines; Radioligand Assay; Receptors, Nicotinic; Serotonin; Stress, Psychological

2009
Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease.
    Neurobiology of aging, 2011, Volume: 32, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Disease Models, Animal; Ganglionic Stimulants; Learning; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Synaptic Transmission; Up-Regulation

2011
Sex differences in response to nicotine in C57Bl/6:129SvEv mice.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2009, Volume: 11, Issue:7

    Topics: Analysis of Variance; Animals; Behavior, Animal; Choice Behavior; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nicotine; Sex Characteristics; Sex Factors; Species Specificity

2009
Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets.
    Journal of perinatal medicine, 2009, Volume: 37, Issue:5

    Topics: Animals; Animals, Newborn; Apoptosis Inducing Factor; Base Sequence; Brain-Derived Neurotrophic Factor; Caspase 3; Disease Models, Animal; DNA Primers; Gene Expression; Hippocampus; Hypoxia; Microtubule-Associated Proteins; Neuroprotective Agents; Nicotine; RNA, Messenger; Swine; Tissue Distribution

2009
Effect of nicotine exposure during pregnancy and lactation on maternal, fetal, and postnatal rat IGF-II profile.
    Reproductive sciences (Thousand Oaks, Calif.), 2009, Volume: 16, Issue:9

    Topics: Adaptation, Physiological; Animals; Animals, Newborn; Disease Models, Animal; Female; Fetal Development; Fetal Growth Retardation; Gestational Age; Insulin-Like Growth Factor II; Lactation; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar

2009
Increased apoptosis and reduced neuronal and glial densities in the hippocampus due to nicotine and ethanol exposure in adolescent mice.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2009, Volume: 27, Issue:6

    Topics: Aging; Alcohol-Induced Disorders, Nervous System; Animals; Apoptosis; Cell Count; Central Nervous System Depressants; Disease Models, Animal; Drug Interactions; Ethanol; Female; Hippocampus; In Situ Nick-End Labeling; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroglia; Neurons; Nicotine; Nicotinic Agonists; Smoking

2009
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
    Psychopharmacology, 2009, Volume: 206, Issue:2

    Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Indans; Learning Disabilities; Male; Maze Learning; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Antagonists; Physostigmine; Pilocarpine; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine; Theta Rhythm

2009
Chronic nicotine treatment increases nAChRs and microglial expression in monkey substantia nigra after nigrostriatal damage.
    Journal of molecular neuroscience : MN, 2010, Volume: 40, Issue:1-2

    Topics: Animals; Biomarkers; Cell Count; Disease Models, Animal; Dopamine; Female; Melanins; Microglia; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Parkinsonian Disorders; Receptors, Nicotinic; Saimiri; Substantia Nigra; Treatment Outcome; Tyrosine 3-Monooxygenase; Up-Regulation

2010
Prenatal nicotine-exposure alters fetal autonomic activity and medullary neurotransmitter receptors: implications for sudden infant death syndrome.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 107, Issue:5

    Topics: Animals; Animals, Newborn; Autonomic Nervous System; Disease Models, Animal; Female; Heart Rate; Humans; Infant, Newborn; Maternal-Fetal Exchange; Medulla Oblongata; Nicotine; Papio; Pregnancy; Receptors, Serotonin; Respiratory Mechanics; Sudden Infant Death

2009
The effects of serotonin and/or noradrenaline reuptake inhibitors on impulsive-like action assessed by the three-choice serial reaction time task: a simple and valid model of impulsive action using rats.
    Behavioural pharmacology, 2009, Volume: 20, Issue:5-6

    Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Behavior, Animal; Choice Behavior; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Impulsive Behavior; Male; Milnacipran; Nicotine; Nicotinic Agonists; Propylamines; Rats; Rats, Wistar; Reaction Time; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors

2009
Sex differences in the self-administration of cannabinoids and other drugs of abuse.
    Psychoneuroendocrinology, 2009, Volume: 34 Suppl 1

    Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Cannabinoids; Cocaine; Disease Models, Animal; Ethanol; Female; Humans; Illicit Drugs; Male; Nicotine; Self Administration; Sex Characteristics; Substance-Related Disorders

2009
Chronic exposure to nicotine impairs cholinergic angiogenesis.
    Vascular medicine (London, England), 2010, Volume: 15, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Capillaries; Disease Models, Animal; Down-Regulation; Endothelial Cells; Gene Expression Regulation, Enzymologic; Hindlimb; Ischemia; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Neovascularization, Physiologic; Nicotine; Nicotinic Agonists; Nitric Oxide Synthase; Receptors, Nicotinic; RNA, Messenger; Time Factors; Vascular Endothelial Growth Factor A

2010
Effects of nicotine on depressive-like behavior and hippocampal volume of female WKY rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2010, Feb-01, Volume: 34, Issue:1

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Depression; Diagnosis, Computer-Assisted; Disease Models, Animal; Drug Administration Schedule; Exploratory Behavior; Female; Hippocampus; Immobility Response, Tonic; Motor Activity; Nicotine; Rats; Rats, Inbred WKY; Rats, Wistar; Stereotaxic Techniques; Swimming; Time Factors

2010
The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 94, Issue:3

    Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Drug Interactions; Male; Morphine; Motor Activity; Nicotine; Pain; Rats; Rats, Sprague-Dawley; Stereoisomerism

2010
Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung.
    Pediatric pulmonology, 2009, Volume: 44, Issue:11

    Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Female; Ganglionic Stimulants; Lung; Male; Nerve Growth Factor; Neurogenic Inflammation; Nicotine; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Respiratory Syncytial Virus Infections; RNA, Messenger; Tobacco Smoke Pollution; Up-Regulation

2009
Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews.
    American journal of physiology. Gastrointestinal and liver physiology, 2010, Volume: 298, Issue:1

    Topics: Afferent Pathways; Animals; Body Weight; Disease Models, Animal; Eating; Fasting; Guam; Mice; Motion Sickness; Nausea; Nicotine; Nicotinic Agonists; Shrews; Species Specificity; Stomach; Taiwan; Vagus Nerve; Vomiting

2010
Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.
    Cardiovascular research, 2010, Mar-01, Volume: 85, Issue:4

    Topics: Adrenomedullin; Animals; Aorta; Atherosclerosis; Calcinosis; Calcium-Binding Proteins; Cell Differentiation; Cell Lineage; Disease Models, Animal; Extracellular Matrix Proteins; Humans; Matrix Gla Protein; Muscle, Smooth, Vascular; Neuropeptides; Nicotine; Nicotinic Agonists; Peptide Hormones; Phenotype; Rats; Signal Transduction; Smad Proteins; Vascular Diseases; Vitamin D; Vitamins

2010
The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking.
    The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:2

    Topics: Animals; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Partial Agonism; Male; Nicotine; Nicotinic Agonists; Nitriles; Piperazines; Rats; Rats, Long-Evans; Receptors, Dopamine D3; Reinforcement Schedule; Self Administration; Tetrahydroisoquinolines; Tobacco Use Disorder

2010
Nicotine self-administration diminishes stress-induced norepinephrine secretion but augments adrenergic-responsiveness in the hypothalamic paraventricular nucleus and enhances adrenocorticotropic hormone and corticosterone release.
    Journal of neurochemistry, 2010, Volume: 112, Issue:5

    Topics: Adrenergic Agents; Adrenocorticotropic Hormone; Animals; Chromatography, High Pressure Liquid; Corticosterone; Disease Models, Animal; Dopamine beta-Hydroxylase; Electrochemistry; Electroshock; Male; Microdialysis; Nicotine; Nicotinic Agonists; Norepinephrine; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Self Administration; Solitary Nucleus; Stress, Psychological; Time Factors

2010
Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:4

    Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Antagonists; Drug Administration Schedule; Flupenthixol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motivation; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reaction Time; Receptors, Dopamine D2; Reward; Signal Transduction; Tobacco Use Disorder

2010
The influence of a chronic adolescent nicotine exposure on ethanol withdrawal severity during adulthood in C3H mice.
    Alcohol (Fayetteville, N.Y.), 2010, Volume: 44, Issue:1

    Topics: Age Factors; Alcohol Withdrawal Seizures; Animals; Behavior, Animal; Body Weight; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Inhalation Exposure; Male; Mice; Mice, Inbred C3H; Nicotine; Nicotinic Agonists; Risk Factors; Severity of Illness Index; Sexual Development; Tobacco Use Disorder

2010
Effects of nicotine on pulmonary surfactant proteins A and D in ovine lung epithelia.
    Pediatric pulmonology, 2010, Volume: 45, Issue:3

    Topics: Administration, Cutaneous; Animals; Blotting, Western; Cotinine; Disease Models, Animal; Female; Fetal Organ Maturity; Immunohistochemistry; Lung; Nicotine; Pregnancy; Pregnancy Trimester, Third; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein D; RNA, Messenger; Sheep; Smoking

2010
The effects of strain and prenatal nicotine exposure on ethanol consumption by adolescent male and female rats.
    Behavioural brain research, 2010, Jul-11, Volume: 210, Issue:2

    Topics: Alcohol Drinking; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Central Nervous System Depressants; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Drinking Behavior; Drug Synergism; Ethanol; Female; Litter Size; Male; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Sex Factors; Species Specificity; Time Factors

2010
Nicotine self-administration differentially modulates glutamate and GABA transmission in hypothalamic paraventricular nucleus to enhance the hypothalamic-pituitary-adrenal response to stress.
    Journal of neurochemistry, 2010, Volume: 113, Issue:4

    Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Disease Models, Animal; Electric Stimulation; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamo-Hypophyseal System; Male; Neuronal Plasticity; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Self Administration; Stress, Psychological; Synaptic Transmission; Tobacco Use Disorder

2010
Effect of nicotine and tobacco administration method on the mechanical properties of healing bone following closed fracture.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2010, Volume: 28, Issue:9

    Topics: Administration, Oral; Animals; Disease Models, Animal; Drug Delivery Systems; Fracture Healing; Fractures, Closed; Infusion Pumps; Male; Nicotiana; Nicotine; Nicotinic Agonists; Plant Extracts; Radiography; Rats; Rats, Sprague-Dawley; Torsion, Mechanical; Water

2010
Nicotine- and caffeine-mediated changes in gene expression patterns of MPTP-lesioned mouse striatum: Implications in neuroprotection mechanism.
    Chemico-biological interactions, 2010, Apr-29, Volume: 185, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Base Sequence; Caffeine; Disease Models, Animal; Gene Expression Regulation; Injections, Intraperitoneal; Male; Mice; MPTP Poisoning; Neostriatum; Neuroprotective Agents; Neurotoxins; Nicotine; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Parkinson Disease; Receptors, Interleukin-1; Reverse Transcriptase Polymerase Chain Reaction; Time Factors

2010
Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction.
    Biological psychiatry, 2010, Aug-01, Volume: 68, Issue:3

    Topics: Analysis of Variance; Animals; Association Learning; Baclofen; Behavior, Addictive; Behavior, Animal; Cerebral Cortex; Conditioning, Classical; Disease Models, Animal; Drug Combinations; Extinction, Psychological; GABA Agonists; Male; Microinjections; Motivation; Muscimol; Nicotine; Nicotinic Agonists; Rats; Reinforcement Schedule; Self Administration; Tobacco Use Disorder

2010
Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:8

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Conditioning, Operant; Cues; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Food Preferences; Microdialysis; Nicotine; Nicotinic Agonists; Prazosin; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Tobacco Use Disorder

2010
Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats.
    European journal of pharmacology, 2010, Jul-10, Volume: 637, Issue:1-3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Cognition Disorders; Disease Models, Animal; Hippocampus; Immunohistochemistry; Male; Maze Learning; Nicotine; Peptide Fragments; Phosphorylation; Rats; Rats, Sprague-Dawley; tau Proteins; Time Factors

2010
[Effect of age on vascular calcification induced by vitamin D3 and nicotine].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2010, Apr-18, Volume: 42, Issue:2

    Topics: Aging; Animals; Aorta, Thoracic; Aortic Diseases; Calcinosis; Cholecalciferol; Disease Models, Animal; Male; Nicotine; Rats; Rats, Sprague-Dawley

2010
Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Apr-21, Volume: 30, Issue:16

    Topics: Animals; Animals, Genetically Modified; Caffeine; Cells, Cultured; Coffee; Disease Models, Animal; Diterpenes; Drosophila; Drosophila Proteins; Female; Humans; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Nicotiana; Nicotine; Parkinson Disease; Plant Extracts

2010
Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis.
    British journal of pharmacology, 2010, Volume: 160, Issue:2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged-Ring Compounds; Cells, Cultured; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Severity of Illness Index; Spiro Compounds

2010
In vivo nicotine exposure in the zebra finch: a promising innovative animal model to use in neurodegenerative disorders related research.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 96, Issue:2

    Topics: Animals; Body Weight; Chromatography, Liquid; Cotinine; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Feces; Finches; Male; Motor Activity; Neurodegenerative Diseases; Nicotine; Songbirds; Tandem Mass Spectrometry; Vocalization, Animal

2010
Enhanced dopamine transporter function in striatum during nicotine withdrawal.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Gene Expression Regulation; Male; Mice; Nicotine; Nicotinic Agonists; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors

2011
The α7-nicotinic acetylcholine receptor and MMP-2/-9 pathway mediate the proangiogenic effect of nicotine in human retinal endothelial cells.
    Investigative ophthalmology & visual science, 2011, Jun-22, Volume: 52, Issue:7

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nicotine; Rats; Rats, Zucker; Receptors, Nicotinic; Retina; Retinal Neovascularization

2011
Novel role of Egr-1 in nicotine-related neointimal formation.
    Cardiovascular research, 2010, Nov-01, Volume: 88, Issue:2

    Topics: Administration, Oral; Animals; Atherosclerosis; Calcium Signaling; Catheterization; Cell Proliferation; Cells, Cultured; Chelating Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Enzyme Activation; ets-Domain Protein Elk-1; Iliac Artery; Ki-67 Antigen; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA Interference; Time Factors; Transfection; Tunica Intima

2010
Protective effect of nicotine on lipopolysaccharide-induced acute lung injury in mice.
    Respiration; international review of thoracic diseases, 2011, Volume: 81, Issue:1

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Drug Administration Schedule; Drug Dosage Calculations; Escherichia coli; HMGB1 Protein; Instillation, Drug; Interleukin-1beta; Kaplan-Meier Estimate; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; Nicotine; Peroxidase; Protective Agents; Treatment Outcome; Tumor Necrosis Factor-alpha

2011
Nicotine worsens the severity of nephropathy in diabetic mice: implications for the progression of kidney disease in smokers.
    American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:4

    Topics: Animals; Blood Glucose; Blood Pressure; Cells, Cultured; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Humans; Kidney Glomerulus; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; NADPH Oxidase 4; NADPH Oxidases; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Smoking; Tyrosine

2010
Orchiectomy modifies the antidepressant-like response of nicotine in the forced swimming test.
    Physiology & behavior, 2010, Nov-02, Volume: 101, Issue:4

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Disease Models, Animal; Drug Interactions; Escape Reaction; Estradiol; Gonadal Steroid Hormones; Immobility Response, Tonic; Male; Nicotine; Orchiectomy; Rats; Rats, Wistar; Stress, Psychological; Swimming; Testosterone

2010
Carbachol alleviates rat cytokine release and organ dysfunction induced by lipopolysaccharide.
    The Journal of trauma, 2011, Volume: 71, Issue:1

    Topics: Animals; Carbachol; Cells, Cultured; Cholinergic Agonists; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Lipopolysaccharides; Macrophages, Peritoneal; Male; Microscopy, Confocal; Multiple Organ Failure; Nicotine; Rats; Rats, Wistar; Survival Rate; Systemic Inflammatory Response Syndrome; Treatment Outcome

2011
Environmental tobacco smoke furthers progression of diabetic nephropathy.
    The American journal of the medical sciences, 2011, Volume: 341, Issue:2

    Topics: Animals; Collagen Type IV; Cotinine; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Fibronectins; Glomerular Mesangium; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nicotine; Risk Factors; Tobacco Smoke Pollution; Transforming Growth Factor beta

2011
Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors.
    Experimental neurology, 2011, Volume: 227, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antigens, CD; Cell Differentiation; Cell Proliferation; Central Nervous System; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Flow Cytometry; Gene Expression Regulation; Lymph Nodes; Magnetic Resonance Imaging; Mice; Mice, Knockout; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; RNA, Messenger; Spleen; Statistics, Nonparametric; T-Lymphocytes, Regulatory

2011
Rosiglitazone improves pancreatic mitochondrial function in an animal model of dysglycemia: role of the insulin-like growth factor axis.
    Endocrine, 2010, Volume: 37, Issue:2

    Topics: Animals; Diabetes Mellitus, Type 2; Diabetes, Gestational; Disease Models, Animal; Female; Glucose Intolerance; Hypoglycemic Agents; Insulin-Like Growth Factor I; Insulin-Secreting Cells; Mitochondria; Nicotine; Pregnancy; Rats; Rats, Wistar; Rosiglitazone; Thiazolidinediones

2010
Effect of platelet-rich plasma on a rabbit model of nicotine-compromised bone healing.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2011, Volume: 69, Issue:1

    Topics: Animals; Bone Regeneration; Connective Tissue; Delayed-Action Preparations; Disease Models, Animal; Mandible; Nicotine; Nicotinic Agonists; Osteogenesis; Osteogenesis, Distraction; Osteotomy; Platelet Count; Platelet-Rich Plasma; Rabbits; Time Factors; Transforming Growth Factor beta1; Wound Healing; X-Ray Microtomography

2011
Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia.
    Behavioural brain research, 2011, Mar-01, Volume: 217, Issue:2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Cerebellar Ataxia; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Ethanol; Injections, Intraventricular; Male; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nitrates; Nitrites; Psychomotor Performance; Receptors, Nicotinic; Time Factors

2011
Long-term development of excessive and inflexible nicotine taking by rats, effects of a novel treatment approach.
    Behavioural brain research, 2011, Mar-01, Volume: 217, Issue:2

    Topics: Administration, Oral; Animals; Behavior, Animal; Body Weight; Choice Behavior; Conditioning, Operant; Corticosterone; Disease Models, Animal; Drinking Behavior; Eating; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Time Factors; Tobacco Use Disorder

2011
Nicotine reverses anhedonic-like response and cognitive impairment in the rat chronic mild stress model of depression: comparison with sertraline.
    Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:8

    Topics: Anhedonia; Animals; Antidepressive Agents; Behavior, Animal; Cognition Disorders; Depression; Disease Models, Animal; Drug Therapy, Combination; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Sertraline; Stress, Psychological; Sucrose

2011
[The protective effect of nicotine on dopaminergic neuron of Parkinson's disease mice].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2007, Volume: 23, Issue:4

    Topics: Animals; Caudate Nucleus; Disease Models, Animal; Dopaminergic Neurons; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nicotine; Parkinson Disease; Tyrosine 3-Monooxygenase

2007
Nicotine-induced damage affects gingival fibroblasts in the gingival tissue of rats.
    Journal of periodontology, 2011, Volume: 82, Issue:8

    Topics: Animals; Cell Count; Cell Proliferation; Disease Models, Animal; Fibroblasts; Gingiva; Male; Maxilla; Nicotine; Nicotinic Agonists; Random Allocation; Rats; Rats, Wistar; Smoking

2011
Vulnerability to nicotine abstinence-related social anxiety-like behavior: molecular correlates in neuropeptide Y, Y2 receptor and corticotropin releasing factor.
    Neuroscience letters, 2011, Mar-03, Volume: 490, Issue:3

    Topics: Amygdala; Animals; Anxiety; CA1 Region, Hippocampal; Conditioning, Operant; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Locomotion; Male; Neuropeptide Y; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; RNA, Messenger; Tobacco Use Disorder

2011
Nicotine effects on rat seizures susceptibility and hippocampal neuronal degeneration.
    Neuro endocrinology letters, 2010, Volume: 31, Issue:6

    Topics: Animals; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electrodes, Implanted; Electrophysiology; Evoked Potentials; Hippocampus; Injections, Intraperitoneal; Motor Cortex; Nerve Degeneration; Neurons; Nicotine; Nicotinic Agonists; Random Allocation; Rats; Rats, Wistar; Seizures

2010
Proteome analysis of the left ventricle in the vitamin D₃ and nicotine-induced rat vascular calcification model.
    Journal of proteomics, 2011, Apr-01, Volume: 74, Issue:4

    Topics: Animals; Blood Pressure; Calcinosis; Cardiomyopathies; Cholecalciferol; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Heart Ventricles; Hypertrophy, Left Ventricular; Male; Nicotine; Proteome; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2011
Nicotine ameliorates impairment of working memory in methamphetamine-treated rats.
    Behavioural brain research, 2011, Jun-20, Volume: 220, Issue:1

    Topics: Animals; Attention; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Food Deprivation; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Methamphetamine; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Spatial Behavior; Sympathomimetics; Time Factors

2011
Counteractive effects of cannabinoid and nicotine-addictive behavior.
    Neuroreport, 2011, Mar-09, Volume: 22, Issue:4

    Topics: Animals; Cannabinoids; Conditioning, Psychological; Contraindications; Disease Models, Animal; Dopamine; Male; Marijuana Abuse; Neuronal Plasticity; Nicotine; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Tobacco Use Disorder; Ventral Tegmental Area

2011
Nicotine-induced differential modulation of autoimmune arthritis in the Lewis rat involves changes in interleukin-17 and anti-cyclic citrullinated peptide antibodies.
    Arthritis and rheumatism, 2011, Volume: 63, Issue:4

    Topics: Animals; Antibodies, Anti-Idiotypic; Arthritis, Experimental; Autoimmune Diseases; Bacterial Proteins; Cell Proliferation; Chaperonin 60; Disease Models, Animal; Interleukin-17; Male; Nicotine; Peptides, Cyclic; Rats; Rats, Inbred Lew; Severity of Illness Index; T-Lymphocytes; Time Factors

2011
Interactions between endocannabinoid and serotonergic systems in mood disorders caused by nicotine withdrawal.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2011, Volume: 13, Issue:4

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Disease Models, Animal; Drug Interactions; Endocannabinoids; Male; Mice; Mood Disorders; Motor Activity; Nicotine; Piperazines; Piperidines; Pyrazoles; Pyridines; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Smoking Cessation; Substance Withdrawal Syndrome

2011
Nicotine and estrogen synergistically exacerbate cerebral ischemic injury.
    Neuroscience, 2011, May-05, Volume: 181

    Topics: Animals; Brain Ischemia; Contraceptives, Oral; Disease Models, Animal; Estrogen Receptor Modulators; Estrogens; Female; Nicotine; Nicotinic Agonists; Organ Culture Techniques; Rats; Rats, Sprague-Dawley

2011
Direct effect of nicotine on mesolimbic dopamine release in rat nucleus accumbens shell.
    Neuroscience letters, 2011, Apr-08, Volume: 493, Issue:1-2

    Topics: Animals; Disease Models, Animal; Dopamine; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reward; Tobacco Use Disorder

2011
Elevation of BACE in an Aβ rat model of Alzheimer's disease: exacerbation by chronic stress and prevention by nicotine.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Chronic Disease; Disease Models, Animal; Male; Nicotine; Rats; Rats, Wistar; Stress, Psychological

2012
Aortic intima-media thickness in nicotine-exposed rat pups during gestation and lactation period.
    European journal of pediatrics, 2011, Volume: 170, Issue:10

    Topics: Algorithms; Animals; Animals, Newborn; Aorta, Abdominal; Birth Weight; Disease Models, Animal; Female; Injections, Intraperitoneal; Lactation; Male; Maternal Exposure; Maternal-Fetal Exchange; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats; Rats, Sprague-Dawley; Tunica Intima; Tunica Media

2011
Exposure to nicotine and ethanol in adolescent mice: effects on depressive-like behavior during exposure and withdrawal.
    Behavioural brain research, 2011, Aug-01, Volume: 221, Issue:1

    Topics: Animals; Body Weight; Choice Behavior; Depression; Disease Models, Animal; Drug Interactions; Ethanol; Female; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Nicotine; Physical Endurance; Sex Characteristics; Substance Withdrawal Syndrome; Sucrose; Time Factors

2011
Adolescent nicotine exposure sensitizes cue-induced reinstatement of cocaine seeking in rats bred for high and low saccharin intake.
    Drug and alcohol dependence, 2011, Oct-01, Volume: 118, Issue:1

    Topics: Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Disease Models, Animal; Extinction, Psychological; Female; Gene-Environment Interaction; Nicotine; Phenotype; Rats; Rats, Sprague-Dawley; Recurrence; Saccharin; Self Administration; Sweetening Agents

2011
Chronic psychosocial stress exacerbates impairment of synaptic plasticity in β-amyloid rat model of Alzheimer's disease: prevention by nicotine.
    Current Alzheimer research, 2011, Volume: 8, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Disease Models, Animal; Male; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Stress, Psychological

2011
The effects of acute, chronic, and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL/6J mice.
    Psychopharmacology, 2011, Volume: 217, Issue:3

    Topics: Animals; Chronic Disease; Conditioning, Classical; Disease Models, Animal; Exploratory Behavior; Fear; Infusion Pumps, Implantable; Learning; Male; Memory; Mice; Mice, Inbred C57BL; Nicotine; Pattern Recognition, Visual; Spatial Behavior; Time Factors

2011
A lack of association between severity of nicotine withdrawal and individual differences in compensatory nicotine self-administration in rats.
    Psychopharmacology, 2011, Volume: 217, Issue:2

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Extinction, Psychological; Infusion Pumps, Implantable; Male; Nicotine; Rats; Rats, Sprague-Dawley; Self Administration; Sensory Thresholds; Substance Withdrawal Syndrome

2011
Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype.
    Behavioural brain research, 2011, Sep-23, Volume: 222, Issue:2

    Topics: Amygdala; Animals; Anxiety; Benzamides; CA3 Region, Hippocampal; Corticosterone; Corticotropin-Releasing Hormone; Disease Models, Animal; Exploratory Behavior; Interpersonal Relations; Male; Motor Activity; Neuropeptide Y; Nicotine; Phenotype; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; RNA, Messenger; Substance Withdrawal Syndrome

2011
Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development.
    Reviews in the neurosciences, 2011, Volume: 22, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Attention; Buspirone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Exploratory Behavior; Mecamylamine; Neurochemistry; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Space Perception; Time Factors; Zebrafish

2011
ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
    Behavioural brain research, 2011, Oct-10, Volume: 224, Issue:1

    Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Calcium; Caspase 3; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Glutathione; Indans; Injections, Intraventricular; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mitochondria; Motor Activity; Neurons; Nicotine; Piperidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Nicotinic; Streptozocin; Tacrine

2011
Ability of baclofen to prevent somatic manifestations and neurochemical changes during nicotine withdrawal.
    Drug and alcohol dependence, 2011, Dec-01, Volume: 119, Issue:1-2

    Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Smoking Cessation; Substance Withdrawal Syndrome; Time Factors

2011
A rat model of diabetic artery calcification.
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:5

    Topics: Alkaline Phosphatase; Animals; Arteriosclerosis; Blotting, Western; Bone Density Conservation Agents; Calcium; Cholecalciferol; Diabetes Complications; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Immunoenzyme Techniques; Male; Nicotine; Nicotinic Agonists; Osteopontin; Rats; Rats, Wistar; Vascular Calcification

2012
Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.
    Journal of immunology (Baltimore, Md. : 1950), 2011, Sep-01, Volume: 187, Issue:5

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; CD4-Positive T-Lymphocytes; Cell Separation; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescent Antibody Technique; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Th1 Cells; Th17 Cells; Th2 Cells

2011
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jul-27, Volume: 31, Issue:30

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Receptors, Nicotinic; Reward; Synaptosomes; Tritium

2011
Social interaction promotes nicotine self-administration with olfactogustatory cues in adolescent rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011, Volume: 36, Issue:13

    Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Female; Nicotine; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Self Administration; Smell; Smoking; Social Behavior; Taste; Tobacco Use Disorder

2011
Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2011, Volume: 13, Issue:11

    Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Fructose; Humans; Kainic Acid; Lipid Peroxidation; Male; Mecamylamine; Mice; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Seizures; Topiramate

2011
Effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in rats.
    Journal of neurotrauma, 2012, Mar-20, Volume: 29, Issue:5

    Topics: Animals; Blotting, Western; Brain Injuries; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Microdialysis; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Signal Transduction

2012
Nicotine restores monoamine neurotransmitter changes in the cortex and hippocampus of reserpinized rats as a model of depression.
    European review for medical and pharmacological sciences, 2011, Volume: 15, Issue:8

    Topics: Animals; Antidepressive Agents; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippocampus; Male; Neurotransmitter Agents; Nicotine; Norepinephrine; Rats; Reserpine; Serotonin

2011
Recruitment of α7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells.
    Future microbiology, 2011, Volume: 6, Issue:8

    Topics: Animals; Antigens, Bacterial; Bacterial Capsules; Brain; Caveolin 1; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Escherichia coli; Escherichia coli Infections; Humans; Membrane Microdomains; Meningitis, Bacterial; Mice; Nicotine; Polysaccharides, Bacterial; Receptors, Nicotinic; Rodent Diseases; Signal Transduction

2011
Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network.
    Addiction biology, 2012, Volume: 17, Issue:1

    Topics: Amygdala; Animals; Behavior, Addictive; Brain; Cluster Analysis; Disease Models, Animal; Dronabinol; Ethanol; Gene Expression; Gene Regulatory Networks; Male; Mice; Mice, Inbred C57BL; Morphine; Nicotine; Principal Component Analysis; Real-Time Polymerase Chain Reaction; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders; Temperance; Time; Transcriptional Activation

2012
Nicotine improves working memory span capacity in rats following sub-chronic ketamine exposure.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011, Volume: 36, Issue:13

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ketamine; Male; Memory, Short-Term; Nicotine; Nicotinic Agonists; Rats; Rats, Inbred Strains

2011
Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in rats.
    Psychopharmacology, 2012, Volume: 220, Issue:3

    Topics: Alkaloids; Animals; Behavior, Animal; Brain; Discrimination Learning; Disease Models, Animal; Male; Motor Activity; Nicotine; Plant Extracts; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration; Tissue Distribution; Tobacco Use Disorder; Tobacco, Smokeless

2012
Gestational IV nicotine produces elevated brain-derived neurotrophic factor in the mesocorticolimbic dopamine system of adolescent rat offspring.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:12

    Topics: Aging; Amphetamine-Related Disorders; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Female; Male; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Tobacco Use Disorder; Ventral Tegmental Area

2011
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: Adenocarcinoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Drinking Water; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)

2011
Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation.
    Life sciences, 2011, Dec-19, Volume: 89, Issue:25-26

    Topics: Analgesics, Opioid; Animals; Corticosterone; Disease Models, Animal; Drug Administration Schedule; Fluorometry; Hypothalamo-Hypophyseal System; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Nicotinic Agonists; Pain; Pituitary-Adrenal System; Receptor Cross-Talk

2011
Long-term nicotine replacement therapy: cancer risk in context.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)

2011
How do we safely get people to stop smoking?
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)

2011
Influence of experimental subarachnoid hemorrhage on nicotine-induced contraction of the rat basilar artery in relation to nicotinic acetylcholine receptors, calcium, and potassium channels.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2013, Volume: 22, Issue:4

    Topics: Animals; Basilar Artery; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglionic Blockers; KATP Channels; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Subarachnoid Hemorrhage; Vasoconstriction; Vasoconstrictor Agents

2013
The effect of nicotine on anti-vascular endothelial growth factor therapy in a mouse model of neovascular age-related macular degeneration.
    Retina (Philadelphia, Pa.), 2012, Volume: 32, Issue:6

    Topics: Adiponectin; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Bungarotoxins; Choroid; Choroidal Neovascularization; Disease Models, Animal; Immunohistochemistry; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; Nicotine; Receptors, Nicotinic; Retinal Pigment Epithelium; Vascular Endothelial Growth Factors

2012
Treatment of experimental periodontal disease with antimicrobial photodynamic therapy in nicotine-modified rats.
    Journal of clinical periodontology, 2011, Volume: 38, Issue:12

    Topics: Alveolar Bone Loss; Animals; Bacteria; Combined Modality Therapy; Dental Prophylaxis; Disease Models, Animal; Immunohistochemistry; Immunosuppressive Agents; Male; Mandible; Molar; Nicotine; Osteoprotegerin; Periodontitis; Photochemotherapy; Photosensitizing Agents; Random Allocation; RANK Ligand; Rats; Rats, Wistar

2011
SU-6656, a selective Src kinase inhibitor, attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012, Volume: 14, Issue:4

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Indoles; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mecamylamine; Mice; Narcotic Antagonists; Nicotine; src-Family Kinases; Substance Withdrawal Syndrome; Sulfonamides; Tobacco Use Disorder

2012
Nicotine attenuates spatial learning deficits induced by sodium metavanadate.
    Neurotoxicology, 2012, Volume: 33, Issue:1

    Topics: Administration, Oral; Analysis of Variance; Animals; Choline O-Acetyltransferase; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Escape Reaction; Gene Expression Regulation; Hippocampus; Learning Disabilities; Locomotion; Male; Maze Learning; Nicotine; Nicotinic Agonists; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Space Perception; Swimming; Vanadates; Vesicular Acetylcholine Transport Proteins

2012
Chronic neonatal nicotine exposure increases excitation in the young adult rat hippocampus in a sex-dependent manner.
    Brain research, 2012, Jan-09, Volume: 1430

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Hippocampus; Male; Nicotine; Nicotinic Agonists; Organ Culture Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reaction Time; Sex Characteristics; Smoking

2012
Nicotine suppresses hyperexcitability of colonic sensory neurons and visceral hypersensivity in mouse model of colonic inflammation.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Volume: 302, Issue:7

    Topics: Action Potentials; Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Electrophysiological Phenomena; Inflammation; Male; Mice; Mice, Inbred C57BL; Nicotine; Real-Time Polymerase Chain Reaction; Sensory Receptor Cells; Sodium Channels

2012
A new criterion for acquisition of nicotine self-administration in rats.
    Drug and alcohol dependence, 2012, Jul-01, Volume: 124, Issue:1-2

    Topics: Animals; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Logistic Models; Male; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Self Administration

2012
Nicotine evoked improvement in learning and memory is mediated through NPY Y1 receptors in rat model of Alzheimer's disease.
    Peptides, 2012, Volume: 33, Issue:2

    Topics: Alzheimer Disease; Amygdala; Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Arginine; Colchicine; Dentate Gyrus; Disease Models, Animal; Escape Reaction; Learning; Male; Maze Learning; Memory; Neuropeptide Y; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Septal Nuclei

2012
Exercise may offset nicotine-induced injury in lung tissue: a preliminary histological study based on a rat model.
    Experimental lung research, 2012, Volume: 38, Issue:4

    Topics: Animals; Catalase; Disease Models, Animal; Glutathione Peroxidase; Immunohistochemistry; Lung; Lung Injury; Male; Microscopy, Electron, Transmission; Nicotine; Physical Exertion; Rats; Rats, Wistar; Smoking; Superoxide Dismutase

2012
Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:8

    Topics: Action Potentials; Animals; Clofibrate; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; Hypolipidemic Agents; Indoles; Male; Neurons; Nicotine; Nucleus Accumbens; PPAR alpha; Rats; Rats, Sprague-Dawley; Reward; Saimiri; Secondary Prevention; Self Administration; Tobacco Use Disorder; Ventral Tegmental Area

2012
Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice.
    Psychopharmacology, 2013, Volume: 226, Issue:4

    Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Extinction, Psychological; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nicotine; Receptors, Opioid, kappa; Recurrence; Risk Factors; Self Administration; Smoking; Stress, Psychological

2013
Nicotine exposure and the progression of chronic kidney disease: role of the α7-nicotinic acetylcholine receptor.
    American journal of physiology. Renal physiology, 2012, Jul-15, Volume: 303, Issue:2

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Disease Progression; Kidney Diseases; Male; NADPH Oxidase 4; NADPH Oxidases; Nephrectomy; Nicotine; Nicotinic Antagonists; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Transforming Growth Factor beta

2012
Adult mice voluntarily progress to nicotine dependence in an oral self-selection assay.
    Neuropharmacology, 2012, Volume: 63, Issue:4

    Topics: Administration, Oral; Animals; Behavior, Animal; Choice Behavior; Disease Models, Animal; Drinking Water; Drug Resistance; Feeding Behavior; Female; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Self Administration; Sex Characteristics; Species Specificity; Substance Withdrawal Syndrome; Tobacco Use Disorder

2012
α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.
    Journal of neuroinflammation, 2012, May-24, Volume: 9

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Astrocytes; Bungarotoxins; Cells, Cultured; Disease Models, Animal; Dopaminergic Neurons; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Degeneration; Neuroprotective Agents; Nicotine; Receptors, Nicotinic

2012
Comparison of nicotine oral consumption and baseline anxiety measures in adolescent and adult C57BL/6J and C3H/Ibg mice.
    Behavioural brain research, 2012, Aug-01, Volume: 233, Issue:2

    Topics: Administration, Oral; Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Food Preferences; Male; Maze Learning; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Sex Factors; Statistics as Topic

2012
Severe cross-modal object recognition deficits in rats treated sub-chronically with NMDA receptor antagonists are reversed by systemic nicotine: implications for abnormal multisensory integration in schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:10

    Topics: Animals; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Ketamine; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Schizophrenia

2012
The effects of short-term nicotine administration on behavioral and oxidative stress deficiencies induced in a rat model of Parkinson's disease.
    Psychiatria Danubina, 2012, Volume: 24, Issue:2

    Topics: Adrenergic Agents; Animals; Behavior, Animal; Disease Models, Animal; Ganglionic Stimulants; Glutathione Peroxidase; Lipid Peroxidation; Male; Maze Learning; Memory, Short-Term; Nicotine; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Substantia Nigra; Temporal Lobe

2012
Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 102, Issue:1

    Topics: Alcohol Drinking; Alkaloids; Animals; Azocines; Behavior, Addictive; Choice Behavior; Dihydro-beta-Erythroidine; Disease Models, Animal; Ethanol; Ligands; Lobeline; Male; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Receptors, Nicotinic; Signal Transduction

2012
Prenatal nicotine exposure mouse model showing hyperactivity, reduced cingulate cortex volume, reduced dopamine turnover, and responsiveness to oral methylphenidate treatment.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Jul-04, Volume: 32, Issue:27

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine; Female; Gyrus Cinguli; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Models, Neurological; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Smoking

2012
Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine.
    Neuropharmacology, 2013, Volume: 64

    Topics: Animals; Behavior, Animal; Cognition Disorders; Crosses, Genetic; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Drug Interactions; Female; Male; Mice; Mice, Knockout; Nerve Tissue Proteins; Neural Inhibition; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Psychomotor Disorders; Receptor, Serotonin, 5-HT1A; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists

2013
Neurohormonal modulation of the innate immune system is proinflammatory in the prehypertensive spontaneously hypertensive rat, a genetic model of essential hypertension.
    Circulation research, 2012, Oct-12, Volume: 111, Issue:9

    Topics: Angiotensin II; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Hypertension; Immunity, Innate; Inflammation; Macrophages; Male; Neurotransmitter Agents; Nicotine; Prehypertension; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spleen

2012
The effect of transdermal nicotine on fracture healing in a rabbit model.
    Journal of orthopaedic trauma, 2012, Volume: 26, Issue:12

    Topics: Administration, Cutaneous; Animals; Compressive Strength; Disease Models, Animal; Elastic Modulus; Fracture Healing; Humans; Male; Nicotine; Rabbits; Radiography; Tensile Strength; Tibia; Tibial Fractures

2012
Effects of adolescent nicotine exposure and withdrawal on intravenous cocaine self-administration during adulthood in male C57BL/6J mice.
    Addiction biology, 2014, Volume: 19, Issue:1

    Topics: Adolescent; Adolescent Behavior; Age of Onset; Analysis of Variance; Animals; Body Weight; Catheterization; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cotinine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Humans; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Nicotine; Random Allocation; Rats; Self Administration; Tobacco Use Disorder

2014
Sex-specific perinatal nicotine-induced asthma in rat offspring.
    American journal of respiratory cell and molecular biology, 2013, Volume: 48, Issue:1

    Topics: Airway Resistance; Animals; Animals, Newborn; Asthma; Disease Models, Animal; Female; Lung Compliance; Male; Muscle, Smooth; Nicotine; PPAR gamma; Pregnancy; Rats; Rats, Sprague-Dawley; Rosiglitazone; Sex Characteristics; Smoking; Thiazolidinediones; Trachea

2013
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.
    British journal of pharmacology, 2013, Volume: 169, Issue:3

    Topics: Acute Pain; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Behavior, Animal; Body Temperature Regulation; Bridged Bicyclo Compounds, Heterocyclic; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nociceptive Pain; Pain Measurement; Phenylurea Compounds; Quinuclidines

2013
Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model.
    Experimental diabetes research, 2012, Volume: 2012

    Topics: Animals; Cataract; Chemokine CCL11; Diabetes Complications; Diabetes Mellitus, Type 1; Disease Models, Animal; Disease Progression; Eye; Hyperglycemia; Immunologic Factors; Injections, Subcutaneous; Interleukin-4; Interleukin-6; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Streptozocin

2012
Role of α7- and α4β2-nAChRs in the neuroprotective effect of nicotine in stress-induced impairment of hippocampus-dependent memory.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:5

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Dihydro-beta-Erythroidine; Disease Models, Animal; Drug Delivery Systems; Hippocampus; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Stress, Psychological; Time Factors

2013
Is nicotine protective against Parkinson's disease? An experimental analysis.
    CNS & neurological disorders drug targets, 2012, Nov-01, Volume: 11, Issue:7

    Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Interneurons; Male; Nerve Tissue Proteins; Neuroprotective Agents; Nicotine; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Substantia Nigra

2012
Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors.
    European journal of pharmacology, 2013, Jan-15, Volume: 699, Issue:1-3

    Topics: Animals; Antiemetics; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Erythromycin; Female; Gastric Mucosa; Gastrointestinal Agents; Gastrointestinal Motility; Male; Motilin; Muscle Contraction; Nicotine; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Shrews; Stomach; Vagus Nerve; Vomiting

2013
Effect of hyperbaric oxygen therapy on healing in an experimental model of degloving injury in tails of nicotine-treated rats.
    The Journal of hand surgery, European volume, 2013, Volume: 38, Issue:4

    Topics: Animals; Disease Models, Animal; Hyperbaric Oxygenation; Male; Nicotine; Random Allocation; Rats; Soft Tissue Injuries; Tail; Wound Healing

2013
Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats.
    Addiction biology, 2014, Volume: 19, Issue:4

    Topics: Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Operant; Cues; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Nicotine; Piperidines; Rats; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Sucrose; Tobacco Use Disorder

2014
Nicotine vapor inhalation escalates nicotine self-administration.
    Addiction biology, 2014, Volume: 19, Issue:4

    Topics: Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mecamylamine; Molecular Sequence Data; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Volatilization

2014
Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:3

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; G-Protein-Coupled Receptor Kinase 5; Indoles; Male; Maze Learning; Mecamylamine; Mice; Nicotine; Pyrroles; Substance Withdrawal Syndrome

2013
Cardio-respiratory response to moderate chloral hydrate sedation in young lambs.
    Acta paediatrica (Oslo, Norway : 1992), 2013, Volume: 102, Issue:4

    Topics: Animals; Cardiovascular System; Chloral Hydrate; Disease Models, Animal; Fetus; Functional Residual Capacity; Hypnotics and Sedatives; Infusions, Intravenous; Lung; Nicotine; Respiration; Respiratory Function Tests; Sheep, Domestic

2013
Angiotensin-(1-7) inhibits vascular calcification in rats.
    Peptides, 2013, Volume: 42

    Topics: Actins; Alkaline Phosphatase; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Biomarkers; Calcium-Binding Proteins; Calponins; Cholecalciferol; Cytoskeletal Proteins; Disease Models, Animal; Gene Expression Regulation; Male; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Nicotine; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Vascular Calcification

2013
Electrophysiological and pharmacological evaluation of the nicotinic cholinergic system in chagasic rats.
    BMC pharmacology & toxicology, 2013, Jan-07, Volume: 14

    Topics: Animals; Bungarotoxins; Chagas Cardiomyopathy; Dihydro-beta-Erythroidine; Disease Models, Animal; Electrocardiography; Heart; In Vitro Techniques; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Vagus Nerve

2013
The nicotine-mediated decline in l-dopa-induced dyskinesias is associated with a decrease in striatal dopamine release.
    Journal of neurochemistry, 2013, Volume: 125, Issue:2

    Topics: Animals; Antiparkinson Agents; Autoradiography; Corpus Striatum; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Induced; Levodopa; Male; Nicotine; Nicotinic Agonists; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2013
Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors.
    BMC neuroscience, 2013, Feb-09, Volume: 14

    Topics: Analysis of Variance; Animals; Anxiety; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred ICR; Nicotine; Piperidines; Pyrazoles; Receptors, Cannabinoid; Restraint, Physical

2013
Mechanism of intervertebral disc degeneration caused by nicotine in rabbits to explicate intervertebral disc disorders caused by smoking.
    Spine, 2002, Jul-01, Volume: 27, Issue:13

    Topics: Animals; Blood Vessels; Disease Models, Animal; Drug Administration Schedule; Female; Infusion Pumps, Implantable; Intervertebral Disc; Intervertebral Disc Displacement; Male; Microcirculation; Nicotine; Rabbits; Spinal Cord

2002
Cholinergic receptor activity after quinolinic acid caused cerebral injury in rats.
    Chinese medical journal, 2002, Volume: 115, Issue:8

    Topics: Alzheimer Disease; Animals; Brain; Choline O-Acetyltransferase; Disease Models, Animal; Learning; Male; Memory; Nicotine; Quinolinic Acid; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Cholinergic

2002
Investigating the actions of bupropion on dependence-related effects of nicotine in rats.
    Psychopharmacology, 2003, Volume: 165, Issue:4

    Topics: Animals; Avoidance Learning; Bupropion; Conditioning, Operant; Discrimination Learning; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Antagonism; Male; Nicotine; Random Allocation; Rats; Reference Values; Tobacco Use Disorder

2003
An arterially perfused decerebrate preparation of Suncus murinus (house musk shrew) for the study of emesis and swallowing.
    Experimental physiology, 2002, Volume: 87, Issue:5

    Topics: Animals; Aorta, Thoracic; Decerebrate State; Deglutition; Disease Models, Animal; Diterpenes; Electric Stimulation; Esophagus; Female; Heart Rate; Male; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Perfusion; Phrenic Nerve; Physical Stimulation; Pyrimidinones; Reflex; Respiratory Mechanics; Shrews; Vagus Nerve; Video Recording; Vomiting

2002
Nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats.
    Journal of the American College of Cardiology, 2003, Feb-05, Volume: 41, Issue:3

    Topics: Animals; Apoptosis; Disease Models, Animal; Female; Ganglionic Stimulants; Heart Diseases; In Vitro Techniques; Lipopolysaccharides; Male; Myocytes, Cardiac; Nicotine; Rats; Rats, Sprague-Dawley; Time Factors

2003
Nicotine promotes arteriogenesis.
    Journal of the American College of Cardiology, 2003, Feb-05, Volume: 41, Issue:3

    Topics: Angiogenesis Inducing Agents; Angiography; Animals; Arteries; Disease Models, Animal; Endothelium, Vascular; Fibroblast Growth Factor 2; Ganglionic Stimulants; Hemodynamics; Humans; In Vitro Techniques; Ischemia; Leg; Neovascularization, Physiologic; Nicotine; Rabbits; Umbilical Veins

2003
Chronic nicotine treatment attenuates alpha 7 nicotinic receptor deficits following traumatic brain injury.
    Neuropharmacology, 2003, Volume: 44, Issue:2

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Isradipine; Male; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Protein Isoforms; Pyridines; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Tritium

2003
Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats.
    European journal of pharmacology, 2003, Apr-11, Volume: 466, Issue:1-2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; Hippocampus; In Vitro Techniques; Injections, Subcutaneous; Kindling, Neurologic; Mice; Motor Activity; Nicotine; Nicotinic Antagonists; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Seizures

2003
Dietary restriction and nicotine can reduce anxiety in female rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:7

    Topics: Age Factors; Animals; Anxiety; Behavior, Animal; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Maze Learning; Nicotine; Nicotinic Agonists; Rats; Time Factors

2003
Adolescent-onset nicotine self-administration modeled in female rats.
    Psychopharmacology, 2003, Volume: 169, Issue:2

    Topics: Adolescent; Age Factors; Age of Onset; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Hypothermia; Infusions, Intravenous; Injections, Subcutaneous; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Self Administration; Time Factors

2003
Effects of nicotine on heart dimensions and blood volume in male and female rats.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003, Volume: 5, Issue:3

    Topics: Animals; Blood Volume; Disease Models, Animal; Female; Ganglionic Stimulants; Heart; Male; Nicotine; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Smoking

2003
Prenatal nicotine increases testosterone levels in the fetus and female offspring.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003, Volume: 5, Issue:3

    Topics: Animals; Disease Models, Animal; Female; Ganglionic Stimulants; Male; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Risk Factors; Smoking; Testosterone

2003
Characterization of spontaneous and precipitated nicotine withdrawal in the mouse.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2

    Topics: Animals; Disease Models, Animal; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Antagonists; Substance Withdrawal Syndrome; Time Factors; Tobacco Use Disorder

2003
Dopamine responsiveness to drugs of abuse: A shell-core investigation in the nucleus accumbens of the mouse.
    Synapse (New York, N.Y.), 2003, Dec-15, Volume: 50, Issue:4

    Topics: Amphetamine; Anesthetics, Local; Animals; Calbindins; Central Nervous System Depressants; Central Nervous System Stimulants; Cocaine; Disease Models, Animal; Dopamine; Ethanol; Extracellular Space; Illicit Drugs; Immunohistochemistry; Male; Mice; Microdialysis; Morphine; Narcotics; Nicotine; Nicotinic Agonists; Nucleus Accumbens; S100 Calcium Binding Protein G; Substance-Related Disorders; Time Factors

2003
Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:1

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Colonic Neoplasms; Disease Models, Animal; ErbB Receptors; Genes, src; Lipoxygenase; Mice; Mice, Nude; Neoplasm Transplantation; Nicotine; Phosphorylation; Signal Transduction; Transplantation, Heterologous

2004
Nicotine withdrawal induces subsensitivity of hypothalamic-pituitary-adrenal axis to stress in rats: implications for precipitation of depression during smoking cessation.
    Psychoneuroendocrinology, 2004, Volume: 29, Issue:2

    Topics: Adaptation, Physiological; Adrenal Cortex Function Tests; Animals; Corticosterone; Depression; Dexamethasone; Disease Models, Animal; Glucocorticoids; Hippocampus; Hypothalamo-Hypophyseal System; Male; Nicotine; Nicotinic Agonists; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Glucocorticoid; Smoking Cessation; Stress, Psychological; Substance Withdrawal Syndrome

2004
Nicotine stimulates osteoclast resorption in a porcine marrow cell model.
    Journal of periodontology, 2003, Volume: 74, Issue:10

    Topics: Analysis of Variance; Animals; Bone Marrow Cells; Bone Resorption; Calcium Phosphates; Cells, Cultured; Disease Models, Animal; Female; Microscopy, Electron, Scanning; Nicotine; Nicotinic Agonists; Osteoclasts; Statistics, Nonparametric; Swine

2003
Short-term adolescent nicotine exposure in rats elicits immediate and delayed deficits in T-lymphocyte function: critical periods, patterns of exposure, dose thresholds.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003, Volume: 5, Issue:6

    Topics: Adolescent; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglionic Stimulants; Humans; Infusions, Intravenous; Injections, Subcutaneous; Male; Nicotine; Rats; Rats, Sprague-Dawley; T-Lymphocytes

2003
Sex-selective hippocampal alterations after adolescent nicotine administration: effects on neurospecific proteins.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003, Volume: 5, Issue:6

    Topics: Adolescent; Animals; Biomarkers; Disease Models, Animal; Ganglionic Stimulants; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Neurofilament Proteins; Nicotine; Rats; Rats, Sprague-Dawley; Sex Factors; Substance Withdrawal Syndrome

2003
Nicotine increases size and severity of experimental choroidal neovascularization.
    Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:1

    Topics: Administration, Oral; Animals; Cell Division; Choroid; Choroidal Neovascularization; Disease Models, Animal; Drug Combinations; Female; Fluorescein Angiography; Hexamethonium; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Platelet-Derived Growth Factor; Vascular Endothelial Growth Factor A

2004
Impaired gastric motility in the gastroesophageal reflux rat model: an in vitro study.
    The Journal of surgical research, 2003, Volume: 115, Issue:2

    Topics: Animals; Carbachol; Cholinergic Agonists; Disease Models, Animal; Gastric Emptying; Gastric Fundus; Gastroesophageal Reflux; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Serotonin

2003
Nicotine attenuates spatial learning deficits induced in the rat by perinatal lead exposure.
    Brain research, 2004, Feb-27, Volume: 999, Issue:1

    Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Female; Lead Poisoning, Nervous System, Childhood; Maze Learning; Memory Disorders; Memory, Short-Term; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Reaction Time; Receptors, Nicotinic

2004
Strain-specificity in nicotine attenuation of phencyclidine-induced disruption of prepulse inhibition in mice: relevance to smoking in schizophrenia patients.
    Behavior genetics, 2004, Volume: 34, Issue:3

    Topics: Animals; Disease Models, Animal; Hallucinogens; Humans; Male; Mice; Mice, Inbred Strains; Nicotine; Phencyclidine; Schizophrenia; Smoking Prevention; Species Specificity

2004
Intrathecal xenogeneic chromaffin cell grafts reduce nociceptive behavior in a rodent tonic pain model.
    Experimental neurology, 2004, Volume: 186, Issue:2

    Topics: Adrenal Medulla; Animals; Behavior, Animal; Blotting, Western; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Chromogranin A; Chromogranins; Disease Models, Animal; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Enkephalin, Methionine; Graft Survival; Immunohistochemistry; Male; Morphine; Narcotics; Nicotine; Nicotinic Agonists; Pain Measurement; Pain, Intractable; Random Allocation; Rats; Rats, Sprague-Dawley; Subarachnoid Space; Swine; Time Factors; Transplantation, Heterologous; Tyrosine 3-Monooxygenase

2004
Nicotine effects on alveolar bone changes induced by occlusal trauma: a histometric study in rats.
    Journal of periodontology, 2004, Volume: 75, Issue:3

    Topics: Alveolar Bone Loss; Alveolar Process; Animals; Dental Occlusion, Traumatic; Disease Models, Animal; Male; Matched-Pair Analysis; Nicotine; Nicotinic Agonists; Periodontitis; Random Allocation; Rats; Rats, Wistar; Sodium Chloride; Statistics, Nonparametric

2004
(-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity.
    Neuroscience, 2004, Volume: 125, Issue:3

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Survival; Corticosterone; Disease Models, Animal; Drug Interactions; Hippocampus; In Vitro Techniques; Male; Mifepristone; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic

2004
Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma.
    Brain research. Molecular brain research, 2004, May-19, Volume: 124, Issue:2

    Topics: Animals; Binding, Competitive; Chemokine CCL2; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Inflammation; Inflammation Mediators; Male; NF-kappa B; Nicotine; Nicotinic Antagonists; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Long-Evans; Receptors, Nicotinic; RNA, Messenger; Spinal Cord Compression; Transcription Factor AP-1; Transcription Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Up-Regulation

2004
Nicotine withdrawal in adolescent and adult rats.
    Annals of the New York Academy of Sciences, 2004, Volume: 1021

    Topics: Adolescent; Age Factors; Analysis of Variance; Animals; Blinking; Disease Models, Animal; Drug Administration Schedule; Humans; Infusion Pumps, Implantable; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Disorder

2004
Bupropion (Zyban, Wellbutrin) inhibits nicotine-induced viral reactivation in herpes simplex virus type 1 latent rabbits.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:2

    Topics: Animals; Bupropion; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Interactions; Eye; Female; Herpesvirus 1, Human; Male; Nicotine; Rabbits; Virus Latency; Virus Shedding

2004
Nicotine physical dependence and tolerance in the mouse following chronic oral administration.
    Psychopharmacology, 2005, Volume: 178, Issue:2-3

    Topics: Administration, Oral; Animals; Arousal; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Receptors, Nicotinic; Substance Withdrawal Syndrome

2005
Long-term exposure to nicotine modulates the level and activity of acetylcholine receptors in white blood cells of smokers and model mice.
    Molecular pharmacology, 2004, Volume: 66, Issue:6

    Topics: Animals; Disease Models, Animal; Humans; Kinetics; Mice; Neutrophils; Nicotine; Receptors, Cholinergic; Smoking; Up-Regulation

2004
Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Acetaldehyde; Adolescent; Age Factors; Aging; Animals; Brain; Brain Chemistry; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Nicotiana; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Self Administration; Tobacco Use Disorder

2005
Prolonged nicotine administration results in biphasic, brain-specific changes in kynurenate levels in the rat.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Extracellular Fluid; Glutamic Acid; Hippocampus; Kynurenic Acid; Kynurenine; Male; Nicotine; Rats; Rats, Sprague-Dawley; Smoking; Tobacco Use Disorder; Up-Regulation

2005
Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Adipose Tissue; Animals; Appetite Regulation; Body Weight; Brain; Carrier Proteins; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Energy Metabolism; Hypothalamus; Ion Channels; Leptin; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mitochondrial Proteins; Neuropeptide Y; Nicotine; RNA, Messenger; Smoking; Time Factors; Tobacco Use Disorder; Tumor Necrosis Factor-alpha; Uncoupling Protein 1; Uncoupling Protein 3

2005
Effects of maternal nicotine exposure on lung surfactant system in rats.
    Pediatric pulmonology, 2005, Volume: 39, Issue:2

    Topics: Animals; Chromatography; Disease Models, Animal; Female; Gene Expression; Lung; Maternal Exposure; Maternal-Fetal Exchange; Nicotine; Nicotinic Agonists; Phosphatidylcholines; Pregnancy; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2005
Dopamine D3 receptor ligands block nicotine-induced conditioned place preferences through a mechanism that does not involve discriminative-stimulus or antidepressant-like effects.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Acrylamides; Animals; Antidepressive Agents; Conditioning, Psychological; Discrimination, Psychological; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Female; Isoquinolines; Ligands; Limbic System; Male; Mice; Mice, Knockout; Nicotine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Spatial Behavior; Tobacco Use Disorder

2005
Effects of sleep deprivation, nicotine, and selenium on wound healing in rats.
    The International journal of neuroscience, 2004, Volume: 114, Issue:11

    Topics: Animals; Antioxidants; Disease Models, Animal; Drug Interactions; Fibroblasts; Immunoglobulin G; Male; Neovascularization, Physiologic; Neutrophils; Nicotine; Nicotinic Agonists; Radioimmunodetection; Rats; Rats, Sprague-Dawley; Selenium; Skin; Sleep Deprivation; Wound Healing

2004
Chronic nicotine in hearts with healed ventricular myocardial infarction promotes atrial flutter that resembles typical human atrial flutter.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:6

    Topics: Animals; Atrial Fibrillation; Atrial Flutter; Disease Models, Animal; Dogs; Female; Heart; Humans; Male; Myocardial Infarction; Nicotine

2005
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Feb-22, Volume: 102, Issue:8

    Topics: Age Factors; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium; Disease Models, Animal; Mice; Mice, Transgenic; Nicotine; Phosphorylation; Receptors, Nicotinic; tau Proteins

2005
Nicotine attenuates morphological deficits in a contusion model of spinal cord injury.
    Journal of neurotrauma, 2005, Volume: 22, Issue:2

    Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Locomotion; Male; Neuroprotective Agents; Nicotine; Rats; Rats, Long-Evans; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Thoracic Vertebrae

2005
Modulation of nicotine but not ethanol preference by the mouse Chrna4 A529T polymorphism.
    Behavioral neuroscience, 2005, Volume: 119, Issue:1

    Topics: Animals; Central Nervous System Depressants; Disease Models, Animal; Drinking Behavior; Ethanol; Feeding Behavior; Ganglionic Stimulants; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nicotine; Polymorphism, Genetic; Receptors, Nicotinic; Substance-Related Disorders

2005
Timing of conditioned responding in a nicotine locomotor conditioning preparation: manipulations of the temporal arrangement between context cues and drug administration.
    Behavioural brain research, 2005, Apr-15, Volume: 159, Issue:1

    Topics: Analysis of Variance; Animals; Association Learning; Conditioning, Operant; Cues; Disease Models, Animal; Drug Administration Schedule; Environment; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Reinforcement, Psychology; Time Perception; Tobacco Use Disorder

2005
Potential energetic implications of emesis in the house musk shrew (Suncus murinus).
    Physiology & behavior, 2005, Mar-31, Volume: 84, Issue:4

    Topics: Animals; Disease Models, Animal; Energy Intake; Energy Metabolism; Feeding Behavior; Female; Male; Motion Sickness; Nicotine; Pica; Shrews; Vomiting

2005
Monoamine reuptake inhibition and nicotine receptor antagonism reduce amplitude and gating of auditory evoked potentials.
    Neuroscience, 2005, Volume: 133, Issue:3

    Topics: Animals; Antipsychotic Agents; Biogenic Monoamines; Bupropion; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Evoked Potentials, Auditory; Haloperidol; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Schizophrenia

2005
Periadolescent nicotine administration produces enduring changes in dendritic morphology of medium spiny neurons from nucleus accumbens.
    Neuroscience letters, 2005, Sep-09, Volume: 385, Issue:2

    Topics: Age Factors; Animals; Cell Shape; Dendrites; Disease Models, Animal; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Reward; Risk Factors; Sexual Maturation; Tobacco Use Disorder

2005
Dysfunction of myocardial sarcoplasmic reticulum in rats with myocardial calcification.
    Life sciences, 2005, Jul-15, Volume: 77, Issue:9

    Topics: Animals; Calcinosis; Calcium; Cardiomyopathies; Cholecalciferol; Disease Models, Animal; Heart; Male; Nicotine; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Up-Regulation

2005
How cigarette smoke accelerates abdominal aortic aneurysm.
    Journal of the American College of Surgeons, 2005, Volume: 201, Issue:1

    Topics: Animals; Aortic Aneurysm, Abdominal; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Mice; Nicotiana; Nicotine; Nicotinic Agonists; Pulmonary Emphysema; Smoke

2005
Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jun-29, Volume: 25, Issue:26

    Topics: Animals; Brain; Disease Models, Animal; Male; Nicotine; Rats; Rats, Wistar; Reward; Substance Withdrawal Syndrome; Substance-Related Disorders

2005
Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Animals; Conditioning, Operant; Disease Models, Animal; Immunization, Secondary; Male; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration; Tissue Distribution; Tobacco Use Disorder; Vaccines, Conjugate

2006
Intravenous nicotine self-administration in rats: effects of mecamylamine, hexamethonium and naloxone.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Animals; Association Learning; Brain; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Hexamethonium; Humans; Infusions, Intravenous; Male; Mecamylamine; Naloxone; Nicotine; Nicotinic Antagonists; Rats; Rats, Long-Evans; Receptors, Nicotinic; Receptors, Opioid; Reinforcement Schedule

2006
Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats.
    Brain research, 2005, Oct-05, Volume: 1058, Issue:1-2

    Topics: Animals; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Drug Administration Schedule; Drug Tolerance; Hypothalamus, Posterior; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Ventral Tegmental Area

2005
Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats.
    Brain research bulletin, 2005, Sep-30, Volume: 67, Issue:1-2

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Female; Glutathione; Huntington Disease; Injections, Subcutaneous; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nitro Compounds; Oxidative Stress; Propionates; Rats; Rats, Wistar; Receptors, Nicotinic; Tyrosine 3-Monooxygenase

2005
Reinstatement of nicotine-seeking behavior by drug-associated stimuli after extinction in rats.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Animals; Association Learning; Cues; Disease Models, Animal; Extinction, Psychological; Male; Mecamylamine; Motivation; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement Schedule; Self Administration; Social Environment; Tobacco Use Disorder

2006
Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Age Factors; Animals; Arousal; Association Learning; Choice Behavior; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Injections, Intraperitoneal; Male; Motor Activity; Nicotine; Premedication; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Social Environment; Tobacco Use Disorder

2006
Smoking affects the self-healing capacity of periodontal tissues. A histological study in the rat.
    European journal of oral sciences, 2005, Volume: 113, Issue:5

    Topics: Alveolar Bone Loss; Alveolar Process; Animals; Carbon Monoxide; Disease Models, Animal; Male; Nicotine; Nicotinic Agonists; Osteoblasts; Periodontal Attachment Loss; Periodontal Diseases; Periodontium; Random Allocation; Rats; Rats, Wistar; Smoke; Smoking; Wound Healing

2005
Nicotine as a typical drug of abuse in experimental animals and humans.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Animals; Conditioning, Operant; Disease Models, Animal; Humans; Nicotine; Recurrence; Reinforcement, Psychology; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder

2006
moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila.
    Cell, 2005, Oct-07, Volume: 123, Issue:1

    Topics: Alternative Splicing; Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drosophila melanogaster; Drosophila Proteins; Drug Tolerance; Male; Motor Activity; Neuroglia; Nicotine; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Substance-Related Disorders

2005
Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Animals; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Intravenous; Injections, Subcutaneous; Male; Mecamylamine; Motivation; Motor Activity; Nicotine; Nicotinic Antagonists; Picolines; Premedication; Rats; Rats, Sprague-Dawley; Self Administration; Sucrose

2006
Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:1

    Topics: Animals; Aorta; Atherosclerosis; Chemokine CXCL1; Chemokines; Chemokines, CXC; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Gene Expression; Hypercholesterolemia; Interleukin-1; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NF-kappa B; Nicotine; Nicotinic Agonists; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-sis; Receptors, LDL; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2006
[Nicotine replacement therapies during pregnancy: what do we know about the balance between benefits and risks?].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 2005, Volume: 34, Issue:7 Pt 1

    Topics: Animals; Disease Models, Animal; Female; Fetus; Humans; Nicotine; Nicotinic Agonists; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Risk Assessment; Risk Factors; Smoking; Smoking Cessation; Treatment Outcome

2005
Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes.
    Diabetologia, 2005, Volume: 48, Issue:12

    Topics: Adiposity; Animals; Animals, Newborn; Apoptosis; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Fetus; Glucose; Glucose Tolerance Test; Hemostasis; Insulin; Insulin-Secreting Cells; Nicotine; Obesity; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Random Allocation; Rats; Rats, Wistar

2005
Chronic nicotine induces growth retardation in neonatal rat pups.
    Life sciences, 2006, Feb-23, Volume: 78, Issue:13

    Topics: Animals; Animals, Newborn; Body Weight; Brain; Disease Models, Animal; Female; Growth Disorders; Male; Nicotine; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Sex Characteristics; Weight Gain

2006
[Preparation of vascular calcification in vivo and vascular smooth muscle cell calcification in vitro of rats].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2005, Dec-18, Volume: 37, Issue:6

    Topics: Animals; Calcinosis; Calcium; Disease Models, Animal; Male; Muscle, Smooth, Vascular; Nicotine; Random Allocation; Rats; Rats, Wistar; Vascular Diseases

2005
Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administration.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Animals; Brain Mapping; Disease Models, Animal; Dopamine; Extinction, Psychological; Extracellular Fluid; Infusions, Intravenous; Male; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration; Tobacco Use Disorder

2006
Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats.
    The American journal of gastroenterology, 2006, Volume: 101, Issue:1

    Topics: Animals; Biopsy, Needle; Cotinine; Disease Models, Animal; Female; Immunohistochemistry; Nicotine; Pancreatic Function Tests; Pancreatitis-Associated Proteins; Pancreatitis, Chronic; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Tobacco Smoke Pollution

2006
Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Feb-08, Volume: 26, Issue:6

    Topics: Alcoholism; Animals; Disease Models, Animal; Disease Susceptibility; Humans; Male; Nicotine; Rats; Self Administration; Substance-Related Disorders

2006
Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Crosses, Genetic; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mixed Function Oxygenases; Nicotine; Phenotype; Quantitative Trait Loci; Self Administration; Sex Factors; Tobacco Use Disorder

2006
Preexposure to nicotine alters the subsequent locomotor stimulant effects of bupropion in rats.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2006, Volume: 8, Issue:1

    Topics: Animals; Behavior, Animal; Bupropion; Central Nervous System Stimulants; Disease Models, Animal; Dopamine Uptake Inhibitors; Locomotion; Male; Nicotine; Random Allocation; Rats; Rats, Sprague-Dawley

2006
Nicotinic mechanisms contribute to soman-induced symptoms and lethality.
    Neurotoxicology, 2006, Volume: 27, Issue:4

    Topics: Acetylcholinesterase; Analysis of Variance; Animals; Behavior, Animal; Chemical Warfare Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Hyperkinesis; Lethal Dose 50; Mecamylamine; Mice; Muscarinic Antagonists; Muscle Rigidity; Nicotine; Nicotinic Antagonists; Poisoning; Scopolamine; Soman; Time Factors; Tremor

2006
Behavioral teratogenicity induced by nonforced maternal nicotine consumption.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:3

    Topics: Animals; Association Learning; Attention Deficit and Disruptive Behavior Disorders; Behavior, Animal; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine Uptake Inhibitors; Electroshock; Fear; Female; Mice; Mice, Inbred C57BL; Motor Activity; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Sex Factors

2007
Blockade of nicotinic acetylcholine or dopamine D1-like receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminalis does not precipitate nicotine withdrawal in nicotine-dependent rats.
    Neuroscience letters, 2006, May-29, Volume: 400, Issue:1-2

    Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Dihydro-beta-Erythroidine; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Nicotine; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Nicotinic; Septal Nuclei; Substance Withdrawal Syndrome; Tobacco Use Disorder

2006
Histological changes in intervertebral discs after smoking and cessation: experimental study using a rat passive smoking model.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2006, Volume: 11, Issue:2

    Topics: Animals; Animals, Newborn; Biopsy, Needle; Disease Models, Animal; Immunohistochemistry; Intervertebral Disc Displacement; Male; Nicotine; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Risk Assessment; Sensitivity and Specificity; Smoking; Smoking Cessation

2006
Gestational nicotine-induced changes in adolescent neuronal activity.
    Brain research, 2006, Jun-13, Volume: 1094, Issue:1

    Topics: Adolescent; Aging; Animals; Attention Deficit and Disruptive Behavior Disorders; Behavioral Symptoms; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Male; Neurons; Nicotine; Nucleus Accumbens; Pregnancy; Prenatal Exposure Delayed Effects; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smoking

2006
Chronic nicotine doses down-regulate PDE4 isoforms that are targets of antidepressants in adolescent female rats.
    Biological psychiatry, 2007, Jan-01, Volume: 61, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Animals, Newborn; Brain; Chromosome Mapping; Cyclic Nucleotide Phosphodiesterases, Type 4; Depression; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Female; Humans; Nicotine; Nicotinic Agonists; Oligonucleotide Array Sequence Analysis; Protein Isoforms; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Distribution

2007
Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats.
    The European journal of neuroscience, 2006, Volume: 24, Issue:3

    Topics: Acetylcholine; Animals; Animals, Newborn; Auditory Cortex; Auditory Pathways; Avoidance Learning; Cognition Disorders; Disease Models, Animal; Female; Geniculate Bodies; Language Development Disorders; Learning Disabilities; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Smoking

2006
Effects of nicotine on angiogenesis and restenosis in a rabbit model.
    Cardiology, 2007, Volume: 107, Issue:2

    Topics: Animals; Arteriosclerosis; Collateral Circulation; Coronary Restenosis; Disease Models, Animal; Heart; Hindlimb; Iliac Artery; Kidney; Lipids; Liver; Male; Myocardium; Neovascularization, Pathologic; Neovascularization, Physiologic; Nicotine; Rabbits

2007
Nicotine-induced enhancement of synaptic plasticity at CA3-CA1 synapses requires GABAergic interneurons in adult anti-NGF mice.
    The Journal of physiology, 2006, Oct-15, Volume: 576, Issue:Pt 2

    Topics: Alzheimer Disease; Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Ganglionic Stimulants; Hippocampus; Interneurons; Long-Term Potentiation; Male; Mice; Mice, Transgenic; Nerve Growth Factor; Neuronal Plasticity; Nicotine; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Synapses; Synaptic Transmission

2006
Nicotine-induced changes of glutamate and arginine in naive and chronically alcoholized rats: an in vivo microdialysis study.
    Brain research, 2006, Sep-21, Volume: 1111, Issue:1

    Topics: Alcohol-Induced Disorders, Nervous System; Animals; Arginine; Brain Chemistry; Central Nervous System Depressants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Ethanol; Extracellular Fluid; Glutamic Acid; Male; Microdialysis; Nicotine; Nicotinic Agonists; Nitric Oxide; Nucleus Accumbens; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Disorder

2006
N-methyl-D-aspartate receptor 1 changes in the piglet braintem after nicotine and/or intermittent hypercapnic-hypoxia.
    Neuroscience, 2006, Oct-13, Volume: 142, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Stem; Cell Count; Disease Models, Animal; Female; Gene Expression Regulation; Hypercapnia; Hypoxia; Immunohistochemistry; In Situ Hybridization; Male; Nicotine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sex Factors; Swine; Swine, Miniature

2006
Molecular studies on the protective effect of nicotine in adult-onset hypothyroidism-induced impairment of long-term potentiation.
    Hippocampus, 2006, Volume: 16, Issue:10

    Topics: Age Factors; Animals; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Hippocampus; Hypothyroidism; Long-Term Potentiation; Male; Memory Disorders; Neurogranin; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Phosphoric Monoester Hydrolases; Protein Kinase C; Rats; Rats, Wistar; Time Factors

2006
Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies.
    Journal of neuroscience research, 2006, Volume: 84, Issue:5

    Topics: Action Potentials; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Hypothyroidism; Learning Disabilities; Male; Maze Learning; Memory Disorders; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Spatial Behavior; Thyroidectomy; Time Factors

2006
Impact of chronic nicotine on the development and maintenance of neuropathic hypersensitivity in the rat.
    Psychopharmacology, 2006, Volume: 188, Issue:2

    Topics: Animals; Apoptosis; Back Pain; Behavior, Animal; Chromatography, High Pressure Liquid; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Ligation; Male; Nicotine; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Spinal Nerves; Time Factors

2006
Effects of isoarecolone, a nicotinic receptor agonist in rodent models of nicotine dependence.
    Psychopharmacology, 2006, Volume: 188, Issue:2

    Topics: Animals; Arecoline; Behavior, Animal; Disease Models, Animal; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Self Administration; Tobacco Use Disorder

2006
Mouse cerebellar nicotinic-cholinergic receptor modulation of Delta9-THC ataxia: role of the alpha4beta2 subtype.
    Brain research, 2006, Oct-18, Volume: 1115, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cannabinoid Receptor Agonists; Cerebellar Ataxia; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Hexamethonium; Male; Marijuana Abuse; Mice; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Cannabinoid; Receptors, Nicotinic; Smoking; Time Factors

2006
Nicotine delays tendon-to-bone healing in a rat shoulder model.
    The Journal of bone and joint surgery. American volume, 2006, Volume: 88, Issue:9

    Topics: Animals; Biomechanical Phenomena; Cell Proliferation; Disease Models, Animal; Immunohistochemistry; Male; Nicotine; Nicotinic Agonists; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Rotator Cuff Injuries; Wound Healing

2006
Enamel matrix derivative versus guided tissue regeneration in the presence of nicotine: a histomorphometric study in dogs.
    Journal of clinical periodontology, 2006, Volume: 33, Issue:12

    Topics: Absorbable Implants; Alveolar Bone Loss; Alveolar Process; Animals; Biocompatible Materials; Connective Tissue; Cotinine; Debridement; Dental Cementum; Dental Enamel Proteins; Dental Plaque; Disease Models, Animal; Dogs; Epithelial Attachment; Gingival Recession; Guided Tissue Regeneration, Periodontal; Injections, Subcutaneous; Membranes, Artificial; Nicotine; Nicotinic Agonists; Random Allocation; Surgical Flaps; Wound Healing

2006
Morphometric and morphological features of the ventral prostate in rats submitted to chronic nicotine and alcohol treatment.
    Tissue & cell, 2006, Volume: 38, Issue:5

    Topics: Animals; Atrophy; Cell Membrane; Cell Transformation, Neoplastic; Central Nervous System Depressants; Chronic Disease; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Endoplasmic Reticulum; Epithelial Cells; Ethanol; Fertility; Male; Microscopy, Electron, Transmission; Nicotine; Nicotinic Agonists; Organ Size; Prostate; Prostatic Diseases; Prostatic Intraepithelial Neoplasia; Prostatitis; Rats; Stromal Cells

2006
The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model.
    Gastroenterology, 2006, Volume: 131, Issue:4

    Topics: Animals; Anticoagulants; Appetite Depressants; Dextran Sulfate; Dinitrofluorobenzene; Disease Models, Animal; Eating; Ganglionic Blockers; Ganglionic Stimulants; Hexamethonium; Inflammatory Bowel Diseases; Macrophage Colony-Stimulating Factor; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neural Inhibition; Nicotine; Pylorus; Sincalide; Vagotomy; Vagus Nerve

2006
Anxiolytic effects of nicotine in zebrafish.
    Physiology & behavior, 2007, Jan-30, Volume: 90, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Drug Evaluation, Preclinical; Exploratory Behavior; Locomotion; Nicotine; Reproducibility of Results; Spatial Behavior; Swimming; Zebrafish

2007
Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis.
    Journal of neurochemistry, 2006, Volume: 99, Issue:5

    Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Chronic Disease; Corticosterone; Disease Models, Animal; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Pituitary-Adrenal System; Stress, Psychological; Tobacco Use Disorder

2006
Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys.
    The European journal of neuroscience, 2006, Volume: 24, Issue:7

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Attention; Behavior, Animal; Disease Models, Animal; Macaca mulatta; Male; MPTP Poisoning; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Phenols; Problem Solving; Pyrrolidines; Reaction Time

2006
3-week inhalation exposure to cigarette smoke and/or lipopolysaccharide in AKR/J mice.
    Inhalation toxicology, 2007, Volume: 19, Issue:1

    Topics: Aerosols; Animals; Apoptosis; Biomarkers; Body Weight; Bronchoalveolar Lavage Fluid; Carboxyhemoglobin; Cotinine; Cytokines; Disease Models, Animal; Feasibility Studies; Inhalation Exposure; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred AKR; Neutrophils; Nicotiana; Nicotine; Particle Size; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Respiratory System; Smoke; Time Factors

2007
Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Dec-12, Volume: 103, Issue:50

    Topics: Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Frontal Lobe; gamma-Aminobutyric Acid; Humans; Kinetics; Mice; Mice, Transgenic; Nicotine; Patch-Clamp Techniques; Receptors, Nicotinic; Seizures

2006
Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to alpha6beta2* nAChRs.
    Journal of neurochemistry, 2007, Volume: 100, Issue:1

    Topics: Analysis of Variance; Animals; Autoradiography; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cell Count; Conotoxins; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Interactions; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Paraquat; Protein Binding; Pyridines; Receptors, Nicotinic; Substantia Nigra

2007
Atomoxetine reverses nicotine withdrawal-associated deficits in contextual fear conditioning.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:9

    Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Atomoxetine Hydrochloride; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Fear; Freezing Reaction, Cataleptic; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Propylamines; Substance Withdrawal Syndrome

2007
Action of anti-tussive drugs on the emetic reflex of Suncus murinus (house musk shrew).
    European journal of pharmacology, 2007, Mar-22, Volume: 559, Issue:2-3

    Topics: Analysis of Variance; Animals; Antiemetics; Antitussive Agents; Baclofen; Cevanes; Codeine; Copper Sulfate; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Motion Sickness; Nicotine; Reflex; Scopolamine; Shrews; Vomiting

2007
Nicotine improves cognitive deficits of dopamine transporter knockout mice without long-term tolerance.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:12

    Topics: Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Drinking; Drug Administration Schedule; Drug Interactions; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reaction Time; Receptors, Nicotinic; Time Factors

2007
Involvement of alpha(2)-adrenoceptors in the gastric protective effect of nitroglycerin against acidified ethanol-induced mucosal injury.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:11

    Topics: Animals; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Female; Gastric Mucosa; Male; Mice; Nicotine; Nicotinic Agonists; Nitroglycerin; Organ Size; Receptors, Adrenergic, alpha-2; Stomach Diseases; Vasodilator Agents

2007
Combined exposure to nicotine and ethanol throughout full gestation results in enhanced acquisition of nicotine self-administration in young adult rat offspring.
    Psychopharmacology, 2007, Volume: 193, Issue:2

    Topics: Alcohol Drinking; Animals; Behavior, Addictive; Disease Models, Animal; Ethanol; Female; Male; Maternal-Fetal Exchange; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Self Administration

2007
Ethanol blocks nicotine-induced seizures in mice: comparison with midazolam and baclofen.
    Alcohol (Fayetteville, N.Y.), 2006, Volume: 40, Issue:3

    Topics: Animals; Anticonvulsants; Baclofen; Central Nervous System Depressants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Ethanol; GABA Agents; Male; Mice; Mice, Inbred C57BL; Midazolam; Motor Activity; Nicotine

2006
Chronic nicotine administration. Analysis of the development of hypertension and glutamatergic neurotransmission.
    Brain research bulletin, 2007, May-30, Volume: 72, Issue:4-6

    Topics: Analysis of Variance; Animals; Blood Pressure; Brain; Chromatography, High Pressure Liquid; Competitive Bidding; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glutamic Acid; Hypertension; In Situ Hybridization; Male; Nicotine; Nicotinic Agonists; Protein Binding; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2007
rhBMP-2 (ACS and CRM formulations) overcomes pseudarthrosis in a New Zealand white rabbit posterolateral fusion model.
    Spine, 2007, May-15, Volume: 32, Issue:11

    Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Substitutes; Bone Transplantation; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Female; Humans; Ilium; Lumbar Vertebrae; Nicotine; Osseointegration; Pseudarthrosis; Rabbits; Recombinant Proteins; Spinal Fusion; Time Factors; Tomography, X-Ray Computed; Transforming Growth Factor beta; Transplantation, Autologous

2007
Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:4

    Topics: Acute Disease; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Corticosterone; Disease Models, Animal; Drug Administration Schedule; Electroshock; Hypothalamo-Hypophyseal System; Lipopolysaccharides; Male; Nicotine; Nicotinic Agonists; Pituitary-Adrenal System; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Restraint, Physical; Self Administration; Stress, Psychological; Time Factors

2008
Prevalence, magnitude, and correlates of an extinction burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions.
    Psychopharmacology, 2007, Volume: 194, Issue:3

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Extinction, Psychological; Infusions, Intravenous; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Self Administration; Tobacco Use Disorder

2007
Effects of an aging vascular model on healthy and diseased hearts.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:3

    Topics: Aging; Animals; Cardiomyopathies; Cardiovascular System; Cholecalciferol; Disease Models, Animal; Hypertension; Male; Myocardial Contraction; Myocardial Infarction; Nicotine; Rats; Rats, Wistar; Stroke Volume; Ventricular Dysfunction, Left

2007
Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal.
    Psychopharmacology, 2007, Volume: 195, Issue:3

    Topics: Animals; Antidepressive Agents; Bupropion; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nortriptyline; Rats; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder

2007
Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats.
    Neuropharmacology, 2008, Volume: 54, Issue:1

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Blood Glucose; Body Weight; Cholesterol, HDL; Disease Models, Animal; Eating; Enzyme-Linked Immunosorbent Assay; Female; Hormones; Lipid Metabolism; Male; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sex Factors; Substance Withdrawal Syndrome

2008
Calcium channel antagonists suppress cross-tolerance to the anxiogenic effects of D-amphetamine and nicotine in the mouse elevated plus maze test.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Jan-01, Volume: 32, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Calcium Channel Blockers; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Male; Maze Learning; Mice; Nicotine; Time Factors

2008
Nicotine enlivenment of blood flow recovery following endothelial progenitor cell transplantation into ischemic hindlimb.
    Stem cells and development, 2007, Volume: 16, Issue:4

    Topics: Animals; Apoptosis; Blood Flow Velocity; Cell Culture Techniques; Cell Division; Cell Movement; Disease Models, Animal; Endothelial Cells; Hindlimb; Humans; Ischemia; Laser-Doppler Flowmetry; Leukocytes, Mononuclear; Mice; Nicotine

2007
Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2007, Volume: 59, Issue:3-4

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adrenal Glands; Animals; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Disease Models, Animal; Female; Fetal Development; Fetal Growth Retardation; Fetal Weight; Gene Expression Regulation, Developmental; Injections, Subcutaneous; Maternal Exposure; Maternal-Fetal Exchange; Nicotine; Nicotinic Agonists; Organ Size; Phosphoproteins; Placenta; Pregnancy; Rats; Rats, Wistar; Specific Pathogen-Free Organisms

2007
Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Sep-19, Volume: 27, Issue:38

    Topics: Animals; Arousal; Disease Models, Animal; Dystonic Disorders; Epilepsy, Frontal Lobe; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Mutation; Nicotine; Rats; Species Specificity; Xenopus

2007
Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats.
    Biological psychiatry, 2008, Feb-01, Volume: 63, Issue:3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Choice Behavior; Conditioning, Operant; Disease Models, Animal; Impulsive Behavior; Male; Nicotine; Predictive Value of Tests; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Self Administration; Substance-Related Disorders

2008
Wistar Kyoto and Wistar rats differ in the affective and locomotor effects of nicotine.
    Physiology & behavior, 2008, Jan-28, Volume: 93, Issue:1-2

    Topics: Analysis of Variance; Animals; Association Learning; Avoidance Learning; Conditioning, Classical; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Inbred WKY; Rats, Wistar; Species Specificity; Statistics, Nonparametric; Taste

2008
Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice.
    Gastroenterology, 2007, Volume: 133, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Bridged-Ring Compounds; Cells, Cultured; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation Therapy; Female; Gastric Emptying; Gastroenteritis; Ileus; Intestines; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; NF-kappa B; Nicotine; Nicotinic Agonists; Postoperative Complications; Receptors, Nicotinic; Spiro Compounds; Transcription, Genetic; Vagotomy; Vagus Nerve

2007
The cholinergic anti-inflammatory pathway and the gastrointestinal tract.
    Gastroenterology, 2007, Volume: 133, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Bridged-Ring Compounds; Central Nervous System; Cytokines; Disease Models, Animal; Electric Stimulation Therapy; Gastric Emptying; Gastroenteritis; Humans; Ileus; Intestines; Macrophages, Peritoneal; NF-kappa B; Nicotine; Nicotinic Agonists; Postoperative Complications; Receptors, Nicotinic; Reflex; Spiro Compounds; Transcription, Genetic; Vagotomy; Vagus Nerve

2007
Toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 101, Issue:2

    Topics: Aging; Animals; Behavior, Animal; Blotting, Western; Body Temperature; Brain; Disease Models, Animal; Female; Male; Nicotine; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Seizures; Solvents; Toluene

2008
Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.
    Neuroscience letters, 2007, Dec-18, Volume: 429, Issue:2-3

    Topics: Animals; Astrocytes; Cathepsins; Coloring Agents; Disease Models, Animal; Enzyme Activation; Epilepsy; Gene Expression Regulation, Enzymologic; Gliosis; Hippocampus; Kainic Acid; Lysosomes; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurotoxins; Nicotine; Nicotinic Agonists; Oligonucleotide Array Sequence Analysis; Pyramidal Cells; Up-Regulation

2007
Spontaneous nicotine withdrawal potentiates the effects of stress in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:9

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Behavior, Animal; Dihydro-beta-Erythroidine; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Reflex, Startle; Stress, Psychological; Substance Withdrawal Syndrome; Time Factors

2008
Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:9

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Nicotine; Nicotinic Agonists; Photic Stimulation; Pyridines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Thiazoles; Tobacco Use Disorder

2008
Effect of acupuncture on anxiety-like behavior during nicotine withdrawal and relevant mechanisms.
    Neuroscience letters, 2008, Jan-10, Volume: 430, Issue:2

    Topics: Acupuncture; Amygdala; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Corticotropin-Releasing Hormone; Disease Models, Animal; Male; Maze Learning; Motor Activity; Neuropeptide Y; Nicotine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

2008
Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice.
    Neurotoxicology, 2008, Volume: 29, Issue:1

    Topics: Alkanesulfonic Acids; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Brain Diseases; Caprylates; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Fluorocarbons; Locomotion; Male; Maze Learning; Mental Disorders; Mice; Nicotine; Nicotinic Agonists; Pregnancy; Time Factors

2008
The sliding threshold of modification hypothesis: application to the effect of hypothyroidism or chronic psychosocial stress and nicotine on synaptic plasticity.
    Neuroscience letters, 2008, Jan-17, Volume: 430, Issue:3

    Topics: Animals; Chronic Disease; Disease Models, Animal; Hippocampus; Hypothyroidism; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Models, Neurological; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Phosphoric Monoester Hydrolases; Phosphotransferases; Rats; Rats, Wistar; Stress, Psychological; Synaptic Transmission; Thyroid Hormones

2008
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis.
    Critical care medicine, 2008, Volume: 36, Issue:2

    Topics: Animals; Cholinesterase Inhibitors; Cytokines; Disease Models, Animal; Female; Inflammation Mediators; Mice; Mice, Inbred C57BL; Neostigmine; NF-kappa B; Nicotine; Nicotinic Agonists; Physostigmine; Sepsis

2008
Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 103, Issue:2

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Caspase 3; Cytosol; Disease Models, Animal; Fas Ligand Protein; Female; Fetus; Ganglionic Stimulants; Immunoenzyme Techniques; Injections, Subcutaneous; Insulin-Secreting Cells; Lactation; Male; Maternal Exposure; Maternal-Fetal Exchange; Mitochondria; Mitochondrial Swelling; Nicotine; Pregnancy; Rats; Rats, Wistar

2008
Changed accumbal responsiveness to alcohol in rats pre-treated with nicotine or the cannabinoid receptor agonist WIN 55,212-2.
    Neuroscience letters, 2008, Mar-05, Volume: 433, Issue:1

    Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Central Nervous System Depressants; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Extracellular Fluid; Male; Microdialysis; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Reward; Up-Regulation

2008
Nicotine and type 2 diabetes.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 103, Issue:2

    Topics: Adult; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Humans; Lactation Disorders; Maternal Exposure; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Smoking; Tobacco Use Disorder

2008
Nicotine and caffeine-mediated modulation in the expression of toxicant responsive genes and vesicular monoamine transporter-2 in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype in mouse.
    Brain research, 2008, May-01, Volume: 1207

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Caffeine; Central Nervous System Stimulants; Corpus Striatum; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Disease Models, Animal; Drug Interactions; Gene Expression Regulation; Glutathione Transferase; Male; Mice; MPTP Poisoning; Nicotine; Nicotinic Agonists; Organic Anion Transporters; Time Factors; Vesicular Monoamine Transport Proteins

2008
Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.
    Investigative ophthalmology & visual science, 2008, Volume: 49, Issue:4

    Topics: Animals; Cells, Cultured; Choroid; Choroidal Neovascularization; Disease Models, Animal; Endothelium, Vascular; Female; Humans; Immunoblotting; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Antagonists; Protein Isoforms; Receptors, Nicotinic; Retinal Vessels; RNA, Messenger

2008
The hepatic vagus nerve attenuates Fas-induced apoptosis in the mouse liver via alpha7 nicotinic acetylcholine receptor.
    Gastroenterology, 2008, Volume: 134, Issue:7

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antioxidants; Apoptosis; Benzamides; Bridged Bicyclo Compounds; Caspase 3; Diphosphonates; Disease Models, Animal; Dose-Response Relationship, Drug; fas Receptor; Hepatitis; Kupffer Cells; Liver; Male; Metalloporphyrins; Methane; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Reactive Oxygen Species; Receptors, Nicotinic; Reproducibility of Results; Signal Transduction; Time Factors; Vagotomy; Vagus Nerve

2008
Nicotine promotes contribution of bone marrow-derived cells to experimental choroidal neovascularization in mice.
    Experimental eye research, 2008, Volume: 86, Issue:6

    Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Choroidal Neovascularization; Disease Models, Animal; Female; Fibroblast Growth Factor 2; Laser Coagulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nicotine; Up-Regulation; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A

2008
Tobacco smoke: unraveling a controversial subject.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2008, Volume: 60, Issue:2-3

    Topics: Animal Testing Alternatives; Animals; Cells, Cultured; Disease Models, Animal; Humans; Nicotiana; Nicotine; Smoke; Smoking; Tars; Tissue Culture Techniques; Tobacco Use Disorder; Toxicity Tests

2008
Enhanced behavioral response to nicotine in an animal model of Alzheimer's disease.
    Psychopharmacology, 1983, Volume: 81, Issue:3

    Topics: Alzheimer Disease; Animals; Dextroamphetamine; Disease Models, Animal; Humans; Kainic Acid; Male; Motor Activity; Nicotine; Rats

1983
Schedule-induced self injection of drugs.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:1

    Topics: Alcoholism; Animals; Cocaine; Conditioning, Operant; Corticosterone; Disease Models, Animal; Heroin Dependence; Humans; Nicotine; Nucleus Accumbens; Rats; Reinforcement Schedule; Substance-Related Disorders

1984
[Formation of nicotine addiction in mongrel white rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1984, Volume: 98, Issue:11

    Topics: Animals; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Humans; Male; Nicotine; Rats; Substance-Related Disorders; Time Factors

1984
[Responses of narrow segments of intestines in the congenital aganglionosis rat to various stimulants].
    Nihon Heikatsukin Gakkai zasshi, 1982, Volume: 18, Issue:5

    Topics: Acetylcholine; Animals; Disease Models, Animal; Hirschsprung Disease; In Vitro Techniques; Intestines; Muscle Contraction; Muscle, Smooth; Nicotine; Rats; Rats, Inbred Strains

1982
Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function.
    Brain research bulletin, 1995, Volume: 38, Issue:2

    Topics: Acetylcholine; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Electric Stimulation; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Male; Neurotoxins; Nicotine; Oxotremorine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Stimulation, Chemical

1995
Nicotinic cholinergic normalization of amphetamine-induced loss of auditory gating in freely moving rats.
    Psychopharmacology, 1995, Volume: 119, Issue:2

    Topics: Amphetamine; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Evoked Potentials, Auditory; Ganglia, Sensory; Male; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Schizophrenia; Time Factors; Tubocurarine

1995
Effects of adrenoceptor blockers on the cardiorespiratory response to nicotine in rats.
    African journal of medicine and medical sciences, 1993, Volume: 22, Issue:2

    Topics: Animals; Disease Models, Animal; Drug Interactions; Hemodynamics; Male; Nicotine; Prazosin; Premedication; Propranolol; Rats; Rats, Wistar; Respiration

1993
Effects of adrenergic receptor blockers on adrenaline and nicotine-induced hyperglycaemia in the rat.
    African journal of medicine and medical sciences, 1993, Volume: 22, Issue:4

    Topics: Animals; Blood Glucose; Disease Models, Animal; Dogs; Epinephrine; Hyperglycemia; Male; Nicotine; Practolol; Prazosin; Propranolol; Rats; Rats, Wistar; Time Factors

1993
Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations.
    Journal of cardiovascular pharmacology, 1994, Volume: 24 Suppl 2

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cells, Cultured; Cholecalciferol; Cholesterol; Coronary Vessels; Diltiazem; Disease Models, Animal; Humans; Hypertension; Middle Aged; Muscle, Smooth, Vascular; Nicotine; Nifedipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Risk Factors; Verapamil

1994
Absence of emetic effects of morphine and loperamide in Suncus murinus.
    European journal of pharmacology, 1994, May-02, Volume: 256, Issue:3

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Nicotine; Serotonin; Serotonin Antagonists; Shrews; Vomiting

1994
The effect of nicotine on incorporation of cancellous bone graft in an animal model.
    Spine, 1995, Oct-15, Volume: 20, Issue:20

    Topics: Animals; Bone and Bones; Bone Transplantation; Disease Models, Animal; Fracture Healing; Neovascularization, Pathologic; Nicotine; Rabbits

1995
L-arginine decreases infarct size in rats exposed to environmental tobacco smoke.
    American heart journal, 1996, Volume: 132, Issue:1 Pt 1

    Topics: Animals; Aorta, Abdominal; Arginine; Blood Pressure; Carbon Monoxide; Disease Models, Animal; Endothelium, Vascular; Environmental Exposure; Heart Rate; Isomerism; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Nicotine; Nitric Oxide; Random Allocation; Rats; Rats, Sprague-Dawley; Tobacco Smoke Pollution

1996
The reversal of experimental hemorrhagic shock induced by nicotine and dimethylphenylpiperazinium is adrenal-dependent.
    Resuscitation, 1996, Volume: 31, Issue:2

    Topics: Adrenal Glands; Adrenalectomy; Animals; Dimethylphenylpiperazinium Iodide; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglionic Stimulants; Injections, Intravenous; Male; Nicotine; Rats; Rats, Wistar; Shock, Hemorrhagic

1996
Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 15, Issue:6

    Topics: Amphetamine; Animals; Behavior, Animal; Brain Diseases; Central Nervous System Stimulants; Disease Models, Animal; Female; Hippocampus; Ibotenic Acid; Male; Maze Learning; Mecamylamine; Memory; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Scopolamine

1996
Effect of intermittent cigarette smoke inhalation on tibial lengthening: experimental study on rabbits.
    The Journal of trauma, 1997, Volume: 42, Issue:2

    Topics: Animals; Atmosphere Exposure Chambers; Bone Lengthening; Bone Regeneration; Disease Models, Animal; Male; Nicotine; Nicotinic Agonists; Rabbits; Smoking; Tibia; Tobacco Smoke Pollution; Wound Healing

1997
[Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1997, Volume: 17, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Pindolol; Propranolol; Rats; Rats, Wistar; Tail; Tremor

1997
Elementary particles for models of drug dependence, 10th Okey Memorial Lecture presented at the Institute of Psychiatry, London on 19th March 1997.
    Drug and alcohol dependence, 1997, Dec-15, Volume: 48, Issue:3

    Topics: Animals; Behavior, Addictive; Brain; Cues; Discrimination, Psychological; Disease Models, Animal; Humans; Models, Psychological; Nicotine; Rats; Reward; Self Medication; Substance-Related Disorders; Terminology as Topic; Tobacco Use Disorder

1997
Reversing the inhibitory effect of nicotine on spinal fusion using an osteoinductive protein extract.
    Spine, 1998, Feb-01, Volume: 23, Issue:3

    Topics: Animals; Biomechanical Phenomena; Bone Matrix; Bone Morphogenetic Proteins; Bone Substitutes; Bone Transplantation; Cattle; Collagen; Disease Models, Animal; Drug Carriers; Female; Ilium; Lumbar Vertebrae; Nicotine; Nicotinic Agonists; Pseudarthrosis; Rabbits; Radiography; Spinal Fusion

1998
Elementary particles for models of drug dependence 10th Okey Memorial Lecture presented at the Institute of Psychiatry, London on 19th March 1997.
    Drug and alcohol dependence, 1998, Mar-01, Volume: 50, Issue:1

    Topics: Animals; Behavior, Addictive; Brain; Cues; Discrimination, Psychological; Disease Models, Animal; Humans; Models, Psychological; Nicotine; Rats; Reward; Self Medication; Substance-Related Disorders; Terminology as Topic; Tobacco Use Disorder

1998
Dramatic decreases in brain reward function during nicotine withdrawal.
    Nature, 1998, May-07, Volume: 393, Issue:6680

    Topics: Animals; Brain; Dihydro-beta-Erythroidine; Disease Models, Animal; Infusion Pumps, Implantable; Male; Motivation; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Stimulation; Sensory Thresholds; Substance Withdrawal Syndrome

1998
[Imaging of aortic dissection].
    Cardiologia (Rome, Italy), 1998, Volume: 43, Issue:6

    Topics: Animals; Aortic Aneurysm, Thoracic; Aortic Dissection; Carotid Body; Diagnostic Imaging; Disease Models, Animal; Dogs; Male; Nicotine; Radiography, Thoracic

1998
In-utero and neonatal exposure to secondhand smoke causes vascular dysfunction in newborn rats.
    Journal of the American College of Cardiology, 1998, Volume: 32, Issue:5

    Topics: Acetylcholine; Animals; Animals, Newborn; Aorta, Thoracic; Calcimycin; Cotinine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Ionophores; Maternal Exposure; Muscle, Smooth, Vascular; Nicotine; Nitroglycerin; Phenylephrine; Pregnancy; Rats; Tobacco Smoke Pollution; Vascular Diseases; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

1998
New studies illuminate brain disorders.
    JAMA, 1999, Feb-10, Volume: 281, Issue:6

    Topics: Alzheimer Disease; Animals; Chlamydia Infections; Chlamydophila pneumoniae; Disease Models, Animal; Dogs; Humans; Memory; Narcolepsy; Nicotine; Receptors, Nicotinic

1999
Antidepressant effects of nicotine in an animal model of depression.
    Psychopharmacology, 1999, Volume: 142, Issue:2

    Topics: Alkaloids; Animals; Antidepressive Agents; Azocines; Binding Sites; Body Temperature; Bungarotoxins; Depression; Disease Models, Animal; Iodine Radioisotopes; Male; Motor Activity; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Receptors, Nicotinic; Tritium

1999
Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, May-11, Volume: 96, Issue:10

    Topics: Animals; Carbachol; Disease Models, Animal; Electric Stimulation; Electrophysiology; Gene Targeting; Ion Channels; Mice; Mice, Knockout; Muscle Contraction; Mydriasis; Nicotine; Phenotype; Receptors, Nicotinic; RNA, Messenger; Superior Cervical Ganglion; Urinary Bladder

1999
Selective alpha 7 nicotinic receptor stimulation normalizes chronic cocaine-induced loss of hippocampal sensory inhibition in C3H mice.
    Biological psychiatry, 1999, Nov-15, Volume: 46, Issue:10

    Topics: Animals; Auditory Perception; Chronic Disease; Cocaine-Related Disorders; Disease Models, Animal; Evoked Potentials, Auditory; Hippocampus; Male; Mice; Mice, Inbred C3H; Neural Inhibition; Neurons, Afferent; Nicotine; Nicotinic Agonists; Perceptual Disorders; Receptors, Cholinergic; Receptors, Nicotinic

1999
Development of nicotinic drug therapy for cognitive disorders.
    European journal of pharmacology, 2000, Mar-30, Volume: 393, Issue:1-3

    Topics: Adult; Alzheimer Disease; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Cognition Disorders; Disease Models, Animal; Drug Design; Humans; Learning; Memory; Nicotine; Nicotinic Agonists; Rats; Schizophrenia; Smoking

2000
Smoking and schizophrenia: abnormal nicotinic receptor expression.
    European journal of pharmacology, 2000, Mar-30, Volume: 393, Issue:1-3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Chromosome Mapping; Chromosomes, Human, Pair 15; Cloning, Molecular; Disease Models, Animal; Gene Expression; Humans; Leukocytes, Mononuclear; Mice; Nicotine; Receptors, Nicotinic; Schizophrenia; Smoking

2000
[Analysis of the contractions evoked by sympathetic nerve stimulation, and thermal effect on the guinea-pig vas deferens--study as a model for the thermotherapy of benign prostatic hyperplasia].
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 2000, Volume: 91, Issue:4

    Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Electric Stimulation; Guinea Pigs; Hyperthermia, Induced; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Norepinephrine; Prostatic Hyperplasia; Sympathetic Nervous System; Vas Deferens

2000
An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions.
    Brain research, 2000, Jun-09, Volume: 867, Issue:1-2

    Topics: Adolescent; Age Factors; Animals; Brain; Cerebral Cortex; Cotinine; Disease Models, Animal; Female; Gene Expression; Hippocampus; Humans; Male; Mesencephalon; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sex Factors; Sexual Maturation; Tobacco Use Disorder; Tumor Suppressor Protein p53

2000
Effects of chronic oral nicotine treatment and its withdrawal on locomotor activity and brain monoamines in mice.
    Behavioural brain research, 2000, Volume: 113, Issue:1-2

    Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurotransmitter Agents; Nicotine; Substance Withdrawal Syndrome; Tobacco Use Disorder

2000
Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice.
    The European journal of neuroscience, 2000, Volume: 12, Issue:9

    Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Down Syndrome; Female; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neurons; Nicotine; Nicotinic Agonists; Pregnancy; Receptors, Cholinergic; Trisomy; Tritium

2000
The effect of nicotine on gene expression during spine fusion.
    Spine, 2000, Oct-15, Volume: 25, Issue:20

    Topics: Animals; Bone and Bones; Bone Morphogenetic Proteins; Bone Transplantation; Collagen; Cytokines; Disease Models, Animal; Endothelial Growth Factors; Gene Expression Regulation; Lymphokines; Nicotine; Osteogenesis; Postoperative Complications; Rabbits; RNA, Messenger; Smoking; Spinal Fusion; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing

2000
The analgesic potential of intraventricular polymer-encapsulated adrenal chromaffin cells in a rodent model of chronic neuropathic pain.
    Experimental and clinical psychopharmacology, 2000, Volume: 8, Issue:4

    Topics: Adrenal Glands; Analgesics; Animals; Cattle; Cell Transplantation; Chromaffin Cells; Chronic Disease; Disease Models, Animal; Ganglionic Stimulants; Hand Strength; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Nicotine; Pain; Pain Management; Polymers; Rats; Rats, Sprague-Dawley; Touch

2000
Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra.
    Brain research, 2001, Jan-12, Volume: 888, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chlorisondamine; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Subcutaneous; Male; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Substantia Nigra

2001
Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: implications for SIDS.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:4

    Topics: Adolescent; Animals; Animals, Newborn; Arousal; Brain; Disease Models, Animal; Electroencephalography; Electromyography; Female; Gene Expression Regulation; Gestational Age; Humans; Infant, Newborn; Male; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Risk Factors; Sleep; Sleep, REM; Smoking; Sudden Infant Death; Up-Regulation; Wakefulness

2001
Nicotine-induced NO release in colitis.
    Alimentary pharmacology & therapeutics, 2001, Volume: 15, Issue:4

    Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Ganglionic Stimulants; Humans; Inflammation; Nicotine; Nitric Oxide

2001
Dual effect of chronic nicotine administration: augmentation of jejunitis and amelioration of colitis induced by iodoacetamide in rats.
    International journal of colorectal disease, 2001, Volume: 16, Issue:1

    Topics: Animals; Colitis; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enteritis; Intestinal Mucosa; Iodoacetamide; Jejunal Diseases; Male; Nicotine; Nitric Oxide Synthase; Peroxidase; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric

2001
Muscarinic depression of synaptic transmission in the epileptogenic GABA withdrawal syndrome focus.
    Journal of neurophysiology, 2001, Volume: 85, Issue:5

    Topics: Action Potentials; Animals; Atropine Derivatives; Disease Models, Animal; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Male; Motor Cortex; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Reaction Time; Receptors, Muscarinic; Status Epilepticus; Substance Withdrawal Syndrome; Synaptic Transmission

2001
Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:1

    Topics: Aminopyridines; Amphetamine; Amphetamine-Related Disorders; Animals; Body Weight; Brain; Depression; Disease Models, Animal; Drug Combinations; Electric Stimulation; Fluoxetine; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Piperazines; Rats; Rats, Wistar; Reaction Time; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reward; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission; Tobacco Use Disorder

2001
Effects of adrenoceptor blockers on the glycemic response to nicotine in thyroidectomised rats.
    African journal of medicine and medical sciences, 2000, Volume: 29, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hyperglycemia; Male; Nicotine; Prazosin; Propranolol; Rats; Rats, Wistar; Thyroid Hormones; Thyroidectomy; Time Factors

2000
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jun-15, Volume: 21, Issue:12

    Topics: Aging; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Chronic Disease; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Heterozygote; Hippocampus; In Vitro Techniques; MAP Kinase Signaling System; Maze Learning; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Nicotine; Nicotinic Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Up-Regulation

2001
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
    European journal of pharmacology, 2001, May-18, Volume: 420, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bromocriptine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Fear; Fluvoxamine; Haloperidol; Indophenol; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred ICR; Moclobemide; Motor Activity; Nicotine; Nicotinic Antagonists; Nortriptyline; Physostigmine; Picolinic Acids; Pyrrolidinones; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress, Psychological

2001
An animal model of nicotinic-acid-induced vasodilation: effect of haloperidol, caffeine and nicotine upon nicotinic acid response.
    Schizophrenia research, 2001, Jul-01, Volume: 50, Issue:3

    Topics: Animals; Antipsychotic Agents; Brain; Caffeine; Cerebrovascular Circulation; Disease Models, Animal; Haloperidol; Male; Niacin; Nicotine; Rats; Rats, Sprague-Dawley; Schizophrenia; Vasodilation

2001
Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimental models of bowel dysfunction in vivo.
    Japanese journal of pharmacology, 2001, Volume: 86, Issue:3

    Topics: Animals; Bethanechol; Cholera Toxin; Colonic Diseases, Functional; Defecation; Diarrhea; Dinoprostone; Disease Models, Animal; Intestines; Isoquinolines; Male; Muscarinic Antagonists; Neostigmine; Nicotine; Quinuclidines; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Serotonin; Solifenacin Succinate; Stress, Physiological; Tetrahydroisoquinolines

2001
The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2001, Volume: 3, Issue:4

    Topics: Aconitine; Animals; Behavior, Animal; Brain; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder

2001
Norepinephrine secretion in the hypothalamic paraventricular nucleus of rats during unlimited access to self-administered nicotine: An in vivo microdialysis study.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Nov-15, Volume: 21, Issue:22

    Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Disease Models, Animal; Injections, Intravenous; Male; Microdialysis; Nicotine; Norepinephrine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Lew; Self Administration; Substance Abuse, Intravenous

2001
Nicotine induced seizures blocked by mecamylamine and its stereoisomers.
    Life sciences, 2001, Oct-19, Volume: 69, Issue:22

    Topics: Animals; Disease Models, Animal; Male; Mecamylamine; Molecular Conformation; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Seizures

2001
Effect of nicotine on quinpirole-induced checking behavior in rats: implications for obsessive-compulsive disorder.
    Biological psychiatry, 2002, Jan-15, Volume: 51, Issue:2

    Topics: Animals; Brain; Disease Models, Animal; Humans; Injections, Subcutaneous; Male; Motor Activity; Nicotine; Obsessive-Compulsive Disorder; Quinpirole; Rats; Rats, Long-Evans; Receptors, Nicotinic; Stereotyped Behavior

2002
Prolonged apneas and hypoxia mediated by nicotine and endotoxin in piglets.
    Biology of the neonate, 2002, Volume: 81, Issue:2

    Topics: Animals; Animals, Newborn; Apnea; Disease Models, Animal; Drug Synergism; Hypoxia; Interleukin-1; Lipopolysaccharides; Nicotine; Nicotinic Agonists; Oxygen; Random Allocation; Statistics, Nonparametric; Swine; Swine Diseases; Tumor Necrosis Factor-alpha

2002
Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.
    Molecular pharmacology, 2002, Volume: 61, Issue:3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Substitution; Animals; Dihydro-beta-Erythroidine; Disease Models, Animal; Electrophysiology; Female; Ganglionic Stimulants; Heterozygote; Hippocampus; Lysine; Male; Mice; Mice, Inbred C57BL; Neuroanatomy; Nicotine; Phenotype; Receptors, Nicotinic; Seizures; Threonine

2002
Effects of nicotine on alcohol intake in a rat model of depression.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:1-2

    Topics: Alcohol Drinking; Animals; Depression; Disease Models, Animal; Male; Motor Activity; Nicotine; Rats; Rats, Long-Evans

2002
Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome.
    Journal of neuroscience research, 2002, Apr-01, Volume: 68, Issue:1

    Topics: Acetylcholine; Animals; Calcium; Calcium Signaling; Cell Culture Techniques; Cell Line, Transformed; Choline; Disease Models, Animal; Down Syndrome; Excitatory Amino Acid Agonists; Immunoblotting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neurons; Nicotine; Norepinephrine; Receptors, Glutamate; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Trisomy

2002
Dextran sodium sulphate-induced colitis perturbs muscarinic cholinergic control of colonic epithelial ion transport.
    British journal of pharmacology, 2002, Volume: 135, Issue:7

    Topics: Animals; Atropine; Carbachol; Cholinergic Agonists; Colitis; Dextran Sulfate; Disease Models, Animal; Hexamethonium; Intestinal Mucosa; Ion Transport; Male; Mice; Mice, Inbred BALB C; Narcotics; Nicotine; Receptors, Adrenergic, alpha; Receptors, Cholinergic; Receptors, Muscarinic; Tetrodotoxin

2002
Rethinking nicotine.
    Lab animal, 2001, Volume: 30, Issue:8

    Topics: Alzheimer Disease; Animals; Arteriosclerosis; Carcinoma, Lewis Lung; Disease Models, Animal; Ganglionic Stimulants; Mice; Neovascularization, Pathologic; Nicotine

2001
Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).
    Journal of neurochemistry, 2002, Volume: 81, Issue:3

    Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain Chemistry; Cell Count; Cerebral Cortex; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Female; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Nicotine; Olfactory Pathways; Peptide Fragments; Plaque, Amyloid; Sex Factors; Treatment Outcome

2002
Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins.
    Annals of the New York Academy of Sciences, 2002, Volume: 965

    Topics: Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Humans; Male; Nerve Tissue Proteins; Nicotine; Rats; Rats, Inbred F344; Synapses

2002
Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson's disease.
    Biochemical pharmacology, 2002, Jul-01, Volume: 64, Issue:1

    Topics: Adrenergic Agents; Analysis of Variance; Animals; Corpus Striatum; Cotinine; Disease Models, Animal; Drug Interactions; Female; Male; Neurotoxicity Syndromes; Nicotine; Nicotinic Agonists; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley

2002
Animal model and pharmacokinetic interpretation of nicotine poisoning in man.
    International journal of clinical pharmacology and biopharmacy, 1979, Volume: 17, Issue:1

    Topics: Animals; Blood Pressure; Disease Models, Animal; Humans; Kinetics; Male; Nicotine; Rabbits; Respiration; Salivation; Time Factors

1979
Oral nicotine ingestion and incidence of activity-stress ulcer in the rat.
    Biochemical medicine, 1975, Volume: 14, Issue:1

    Topics: Animals; Disease Models, Animal; Male; Nicotine; Peptic Ulcer; Physical Exertion; Rats; Stomach; Stress, Physiological

1975
Rodent model of nicotine abstinence syndrome.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:3

    Topics: Animals; Behavior, Animal; Body Weight; Disease Models, Animal; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

1992
Reactivity to vasoactive agents of canine basilar arteries exposed to experimental subarachnoid hemorrhage.
    Surgical neurology, 1991, Volume: 35, Issue:6

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Basilar Artery; Calcimycin; Disease Models, Animal; Dogs; Female; In Vitro Techniques; Ischemic Attack, Transient; Male; Neurotransmitter Agents; Nicotine; Oxyhemoglobins; Potassium; Prostaglandins; Subarachnoid Hemorrhage; Vasoconstriction

1991
Chronic administration of nicotine fails to alter the MPTP-induced neurotoxicity in mice.
    General pharmacology, 1991, Volume: 22, Issue:4

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Nervous System; Nicotine; Parkinson Disease

1991
The effect of exposure to nicotine, carbon monoxide, cigarette smoke or cigarette smoke condensate on the mutagenicity of rat urine.
    Mutation research, 1991, Volume: 260, Issue:1

    Topics: Administration, Inhalation; Animals; Carbon Monoxide; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Male; Mutagenicity Tests; Nicotiana; Nicotine; Plants, Toxic; Rats; Rats, Inbred Strains; Smoke; Urine

1991
Progress towards the development of animal models of smoking-related behaviors.
    Journal of addictive diseases, 1991, Volume: 10, Issue:1-2

    Topics: Animals; Arousal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Mice; Mice, Inbred Strains; Nicotine; Receptors, Nicotinic; Smoking; Species Specificity

1991
Extensive spontaneous occlusive arteriosclerosis of the lingual arteries in Fischer rats, a model for the study of human occlusive arteriosclerosis of medium- and small-sized arteries.
    Artery, 1991, Volume: 18, Issue:3

    Topics: Animals; Arteries; Arteriosclerosis; Arteritis; Disease Models, Animal; Giant Cells; Male; Nicotine; Rats; Rats, Inbred F344; Tongue

1991
The actions of nicotine and cocaine in a mouse model of anxiety.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Discrimination, Psychological; Disease Models, Animal; Light; Male; Mice; Mice, Inbred Strains; Nicotine; Substance Withdrawal Syndrome

1989
[Role of nicotine in the induction and maintenance of tobacco dependence].
    Presse medicale (Paris, France : 1983), 1986, Oct-25, Volume: 15, Issue:37

    Topics: Animals; Disease Models, Animal; Humans; Nicotine; Smoking; Tobacco Use Disorder

1986
In vivo and in vitro studies on the use of the guinea pig as a model for virus-provoked airway hyperreactivity.
    The American review of respiratory disease, 1985, Volume: 132, Issue:2

    Topics: Airway Resistance; Animals; Disease Models, Animal; Electric Stimulation; Female; Guinea Pigs; Histamine; In Vitro Techniques; Nicotine; Parainfluenza Virus 3, Human; Paramyxoviridae Infections; Respiratory Tract Infections; Vagus Nerve; Virus Diseases

1985
Chronic nicotine exposure: studies on water intake, body weight, blood pressure and behavior.
    NIDA research monograph, 1987, Volume: 76

    Topics: Animals; Behavior, Animal; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains; Time Factors

1987
Behavioral and biochemical effects of nicotine in an MPTP-induced mouse model of Parkinson's disease.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 28, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Tolerance; Female; Homovanillic Acid; Mice; Mice, Inbred BALB C; Motor Activity; Nicotine; Olfactory Bulb; Parkinson Disease; Pyridines

1987
Effect of various regimens of chronic and acute nicotine exposure on myocardial infarct size in the dog.
    The American journal of cardiology, 1985, May-01, Volume: 55, Issue:11

    Topics: Animals; Cardiac Volume; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Heart; Myocardial Infarction; Myocardium; Nicotine; Organ Size; Sinoatrial Node; Time Factors

1985
An experimental model for the assessment of the effects of cigarette smoke inhalation on pulmonary physiology.
    The Annals of occupational hygiene, 1972, Volume: 15, Issue:2

    Topics: Airway Resistance; Animals; Bronchitis; Disease Models, Animal; Haplorhini; Hemoglobinometry; Lung; Male; Nicotiana; Nicotine; Plants, Toxic; Pulmonary Alveoli; Smoke; Smoking; Spirometry

1972
A laboratory model for behaviour as an indicator of toxicity.
    Ciba Foundation study group, 1970, Volume: 35

    Topics: Acetates; Alkenes; Animals; Animals, Laboratory; Behavior, Animal; Chemical Industry; Disease Models, Animal; Environmental Exposure; Humans; Male; Nicotine; Rats; Smoking; Social Behavior; Tape Recording; Toxicology; Vinyl Compounds

1970