nicotine has been researched along with Ache in 123 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (18.70) | 18.7374 |
| 1990's | 18 (14.63) | 18.2507 |
| 2000's | 42 (34.15) | 29.6817 |
| 2010's | 25 (20.33) | 24.3611 |
| 2020's | 15 (12.20) | 2.80 |
| Authors | Studies |
|---|---|
| Dahdouh, A; Damaj, MI; Dukat, M; Glennon, RA; Martin, BR; Siripurapu, U; Taroua, M | 1 |
| Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Navarro, HA; Ware, R | 1 |
| Anderson, DJ; Barlocco, D; Buckley, M; Bunnelle, WH; Cao, YJ; Curzon, P; Daanen, JF; Dart, MJ; Frost, JM; Gelain, A; Ji, J; Meyer, MD; Putman, CB; Puttfarcken, P; Ryther, KB; Schrimpf, MR; Searle, X; Surowy, C; Toma, L | 1 |
| Brieaddy, LE; Burgess, JP; Damaj, MI; Ivy Carroll, F; Lee, JR; Ma, W; Martin, BR; Navarro, HA; Yokota, Y | 1 |
| Atkinson, RN; Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Mascarella, SW; Navarro, HA; Robinson, TP | 1 |
| Baraldi, PG; Geppetti, P; Materazzi, S; Preti, D | 1 |
| Bartkowiak, JM; Carroll, FI; Castro, AH; Damaj, MI; Luetje, CW; Mascarella, SW; Navarro, HA; Ondachi, PW | 1 |
| Bi, YZ; Hu, L; Kong, YZ; Lu, ZJ; Zhong, JH | 1 |
| Albin Nielsen, K; Arendt-Nielsen, L; Boucher, Y; Carstens, E; Clavé, P; Nielsen, TA; Proctor, G; Reeh, PW | 1 |
| Baynes, T; Dowd, T; Huh, J; Nicholes, M; Schroeder, P | 1 |
| Azizi, H; Khalouzadeh, F; Semnanian, S | 1 |
| Abraham, E; Ahn, H; Attabib, N; Bailey, CS; Christie, S; Cushnie, D; Dea, N; Finkelstein, J; Fisher, C; Glennie, A; Hall, H; Johnson, M; Kelly, A; Manson, N; Nataraj, A; Paquet, J; Rampersaud, R; Soroceanu, A; Stratton, A; Thomas, K; Weber, MH | 1 |
| Ditre, JW; Heckman, BW; Maisto, SA; Powers, JM; Zvolensky, MJ | 1 |
| Berenbaum, F; Courties, A; Head, SR; Lotz, MK; Myers, K; Natarajan, P; Olmer, M; Ordoukhanian, P; Sellam, J | 1 |
| Bartík, P; Petrů, D; Pyšná, J; Pyšný, L; Šagát, P; Suchý, J; Trubák, Z | 1 |
| Kratz, AL; Kuzu, D; Valentine, TR | 1 |
| Ditre, JW; Heckman, BW; LaRowe, LR; Powers, JM | 2 |
| Andersen, EOL; Fischer, L; Gaspar, JC; Guilhen, VA; Lazzarim, MK; Polato, JJ; Sardi, NF; Tobaldini, G | 1 |
| Blair, G; Hawkey, A; Holloway, Z; Ko, A; Levin, ED; McKinney, A; Modarres, J; Pace, C; Rezvani, AH; Rose, JE; Vierling, A; Wells, C | 1 |
| Ditre, JW; LaRowe, LR | 1 |
| Balayssac, D | 1 |
| Andersen, ML; Berro, LF; Hirotsu, C; Pedroni, MN; Tufik, S | 1 |
| Khakpai, F; Zarrindast, MR | 1 |
| Buckner, JD; Ditre, JW; Hughes, MT; Kosiba, JD; LaRowe, LR; Norton, PJ; Smits, JAJ; Zvolensky, MJ | 1 |
| Cheng, L; Feng, B; Guan, S; Li, S; Tian, Z; Wang, X; Wang, Y; Yang, Q; Zhao, M | 1 |
| Dai, Y; Hu, J; Liu, WT; Liu, Y; Teng, P; Zhang, H | 1 |
| Aglawe, MM; Chopde, CT; Kotagale, NR; Kuldhariya, SS; Taksande, BG; Umekar, MJ | 1 |
| Di Cesare Mannelli, L; Ghelardini, C; Zanardelli, M | 1 |
| Marks, MJ | 1 |
| Al'Absi, M; Nakajima, M | 1 |
| Liu, XW; Liu, Z; Lu, SF; Yu, AL; Zhang, ZW | 1 |
| Arendt Nielsen, T; Arendt-Nielsen, L; Boudreau, SA; Nielsen, BP; Wang, K | 1 |
| Carroll, FI; Freitas, KC; Negus, SS | 1 |
| Ditre, JW; Heckman, BW; Kosiba, JD; Maisto, SA; Zale, EL | 1 |
| Parker, R; Vincler, M; Wittenauer, S; Young, T | 1 |
| Benowitz, NL | 1 |
| Bilbe, G; Chaperon, F; Enz, A; Feuerbach, D; Gentsch, C; Hoyer, D; Lingenhoehl, K; McAllister, K; Nozulak, J; Olpe, HR; Vassout, A | 1 |
| Baek, WY; Kim, YM; Kwak, KH; Lim, JO | 1 |
| Dai, TJ; Yan, S; Zeng, YM | 1 |
| Bertrand, D; D'hoedt, D | 1 |
| Baghdoyan, HA; Lydic, R; Wang, W | 1 |
| Chen, HS; Cheng, W; Feng, T; Wang, S; Yin, Q; Zeng, YM | 1 |
| Damaj, MI; Jackson, KJ; Martin, BR; Miles, MF; Walters, CL | 1 |
| Crooks, PA; Holtman, JR; Johnson-Hardy, JK; Wala, EP | 1 |
| Eccleston, C; Keogh, E; Moore, DJ | 1 |
| Domino, EF; Inui, K; Kakigi, R; Miyazaki, T; Wang, X | 1 |
| Chen, X; Damaj, MI; Gamage, TF; Jackson, KJ; Marks, MJ; Vann, RE; Warner, JA | 1 |
| Hooten, WM; Mantilla, CB; Shi, Y; Warner, DO; Weingarten, TN | 2 |
| Afessa, B; Cartin-Ceba, R; Hays, JT; Warner, DO | 1 |
| Fukada, T; Iwakiri, H; Ozaki, M | 1 |
| Kiguchi, N; Kishioka, S; Kobayashi, Y; Maeda, T; Ueno, K; Yamamoto, A; Yamamoto, C | 1 |
| Renner, B; Schreiber, K | 1 |
| Ness, TJ; Redden, DT; Richards, JS; Richardson, EJ; Stewart, CC | 1 |
| Alva, H; Blednov, YA; Harris, RA; Stoffel, M | 1 |
| DE WIED, D; JINKS, R | 1 |
| JANCSO, N; JANCSO-GABOR, A; TAKATS, I | 1 |
| Changeux, JP; Cordero-Erausquin, M; Faure, P; Pons, S | 1 |
| Bernardini, N; Haberberger, RV; Hartmann, P; Kress, M; Kummer, W; Lips, KS | 1 |
| Jing, R; Lu, Y; Pappas, GD; Yeomans, DC | 1 |
| Powledge, TM | 1 |
| Chaijale, N; Commons, KG; Cucchiaro, G | 1 |
| Choi, SS; Han, KJ; Kwon, MS; Lee, HK; Lee, JY; Seo, YJ; Shim, EJ; Suh, HW | 1 |
| Carstens, E; Carstens, MI; Cuellar, JM; Moore, JA; Pinkerton, KE; Simons, CT; Uyeminami, D | 1 |
| Damaj, MI; Martin, BR; Papke, RL; Wiley, JL | 1 |
| Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Navarro, HA | 1 |
| Karsak, M; Valverde, O; Zimmer, A | 1 |
| Kanarek, RB; Mathes, WF | 1 |
| Collins, AC; Damaj, MI; Deshpande, P; Fonck, C; Labarca, C; Lester, HA; Marks, MJ; Martin, BR | 1 |
| Djahanguiri, B; Ghiasvand, F; Golmohammadi, S; Jafari, MR; Zarrindast, MR | 1 |
| Kiguchi, N; Kishioka, S; Maeda, T; Ozaki, M; Tsuruga, M; Yamamoto, A; Yamamoto, C | 1 |
| Inoue, M; Matsumoto, M; Ueda, H; Xie, W | 1 |
| Hapke, U; John, U; Meyer, C; Rumpf, HJ | 1 |
| Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Suh, HW | 1 |
| Fertig, JB; Pomerleau, OF; Turk, DC | 1 |
| Juan, H | 1 |
| Emley, GS; Hutchinson, RR | 1 |
| Caggiula, A; Goettler, J; Grobe, JE; Mitchell, SL; Perkins, KA; Scierka, A; Stiller, RL | 1 |
| Carr, RW; Delaney, CA; Morris, MJ; Roberts, RG; Westerman, RA | 1 |
| Baldauf, J; Jurna, I; Krauss, P | 1 |
| Damaj, MI; Martin, BR | 1 |
| Choi, SR; Chung, KM; Kim, YH; Song, DK; Suh, HW | 1 |
| Basmadjian, G; Nael, R; Seale, TW | 1 |
| Basak, AK; Das, M; Koley, B; Koley, J; Sinha, S | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Manelli, AM; Puttfarcken, PS | 1 |
| Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M | 1 |
| Girdler, SS; Jamner, LD; Jarvik, ME; Shapiro, D | 1 |
| Craft, RM; Milholland, RB | 1 |
| Buerkle, H; Khan, IM; Taylor, P; Yaksh, TL | 1 |
| Changeux, JP; Cordero-Erausquin, M; Damaj, MI; de Kerchove d'Exaerde, A; del Mar Arroyo-Jimenez, M; Huchet, M; Le Novère, N; Léna, C; Marubio, LM | 1 |
| Carroll, FI; Damaj, MI; Martin, BR; Slemmer, JE | 1 |
| Carstens, E; Jinks, SL | 1 |
| Anderson, DJ; Dart, MJ; Decker, MW; Kim, KH; Meyer, MD; Rueter, LE; Sullivan, JP; Williams, M | 1 |
| Carstens, E; Carstens, MI; Dessirier, JM; Jinks, SL; Simons, CT | 1 |
| Carstens, E; Chang, HK; Dessirier, JM; O'Mahony, M | 1 |
| Damaj, MI | 1 |
| Emerich, DF; Francis, JM; Frydel, BR; Lindner, MD; McDermott, PE; Plone, MA; Saydoff, JA | 1 |
| Changeux, JP; Damaj, MI; Epping-Jordan, MP; Marubio, LM; Merlo-Pich, E; Salmon, AM | 1 |
| Dickerson, ED; Ripamonti, C | 1 |
| Anderson, KA; Carstens, E; Carstens, MI; Jinks, SL; Simons, CT | 1 |
| Casida, JE; Cowan, A; Tomizawa, M | 1 |
| Rodgers, RJ | 1 |
| Baraz, LA; Chernilovskaya, PE; Khayutin, VM; Lukoshkova, EV; Sonina, RS | 1 |
| Beermann, B; Jonzon, B; Kaijser, L; Sylvén, C | 1 |
| Cooley, JE; Fowler, SC; Lombardo, TW; Moss, RA; Sult, S; Villarosa, GA | 1 |
| Christensen, MK; Smith, DF | 1 |
| Hayashi, E; Kagawa, Y; Kosuge, T; Takayanagi, N; Tsuji, K; Yamada, S | 1 |
| Simson, PE; Weiss, JM | 1 |
| Roy-Byrne, PP; Uhde, TW | 1 |
| Pappas, GD; Pollard, HB; Sagen, J | 1 |
| Pappas, GD; Sagen, J | 1 |
| Pappas, GD; Perlow, MJ; Sagen, J | 2 |
| Fertig, JB; Pomerleau, OF; Sanders, B | 1 |
| Aceto, MD; Bagley, RS; Dewey, WL; Fu, TC; Martin, BR | 1 |
| Beckett, AH; Hunter, WH; Kourounakis, P | 1 |
| Andreas, K; Dude, C; Queck, KH | 1 |
| Gehlbach, SH; Perry, LD; Williams, WA; Woodall, JS | 1 |
| Nesbitt, PD | 1 |
| Bite, A; Dóda, M; György, L; Phan, DV | 1 |
| Deffenu, G | 1 |
| Fewings, JD; Rand, MJ; Scroop, GC; Whelan, RF | 1 |
13 review(s) available for nicotine and Ache
| Article | Year |
|---|---|
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asthma; Humans; Ion Channel Gating; Neurons; Pain; Peripheral Nervous System Diseases; Pulmonary Disease, Chronic Obstructive; Transient Receptor Potential Channels | 2010 |
[Central neural mechanism of increased pain sensitivity induced by nicotine abstinence].
Topics: Animals; Humans; Nicotine; Pain; Pain Threshold; Smoking Cessation; Tobacco Use Disorder | 2021 |
The Role of TRP Channels in Nicotinic Provoked Pain and Irritation from the Oral Cavity and Throat: Translating Animal Data to Humans.
Topics: Animals; Humans; Mouth; Nicotine; Nicotinic Agonists; Pain; Pharynx; Smoking Cessation; Tobacco Use Cessation Devices; Transient Receptor Potential Channels | 2022 |
[Relation between tobacco smoking and pain: A narrative review of the scientific literature].
Topics: Humans; Nicotine; Pain; Smoking; Smoking Cessation; Tobacco Smoking | 2021 |
The modulatory role of nicotine on cognitive and non-cognitive functions.
Topics: Animals; Anxiety; Body Temperature; Body Weight; Brain; Cognition; Humans; Learning; Nicotine; Nicotinic Agonists; Pain; Receptors, Nicotinic; Reward; Substance-Related Disorders | 2019 |
Genetic matters: thirty years of progress using mouse models in nicotinic research.
Topics: Animals; Gene Expression Regulation; Genetic Variation; Nicotine; Pain; Receptors, Nicotinic | 2013 |
Acute analgesic effects of nicotine and tobacco in humans: a meta-analysis.
Topics: Analgesics; Humans; Nicotiana; Nicotine; Pain; Pain Threshold | 2016 |
Nicotinic acetylcholine receptors: an overview on drug discovery.
Topics: Allosteric Regulation; Analgesics; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular Diseases; Drug Discovery; Hearing; Humans; Myasthenia Gravis; Neurodegenerative Diseases; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Protein Subunits; Psoriasis; Pyridines; Receptors, Nicotinic; Schizophrenia; Smoking; Smoking Cessation; Tobacco Use Disorder | 2009 |
Identifying experimental methods to determine the effect of pain on attention: a review of pain, caffeine, alcohol and nicotine studies.
Topics: Adult; Attention; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Ethanol; Humans; Nicotine; Nicotinic Agonists; Pain; Psychomotor Performance | 2009 |
Smoking and pain: pathophysiology and clinical implications.
Topics: Analgesics; Analgesics, Opioid; Animals; Chronic Disease; Depression; Female; Humans; Ligands; Male; Nicotine; Nicotinic Agonists; Pain; Pain, Postoperative; Receptors, Nicotinic; Risk Factors; Smoking; Smoking Cessation; Treatment Outcome | 2010 |
Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice.
Topics: Animals; Cannabinoid Receptor Modulators; Cognition; Drug Interactions; Emotions; Endocannabinoids; Ethanol; Feeding Behavior; Humans; Locomotion; Marijuana Abuse; Mice; Mice, Knockout; Narcotics; Nicotine; Pain; Receptor, Cannabinoid, CB1 | 2005 |
Strategies for the treatment of cancer pain in the new millennium.
Topics: Analgesics, Opioid; Cannabinoids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Methadone; Morphine; Neoplasms; Nicotine; Pain | 2001 |
Exogenous factors in panic disorder: clinical and research implications.
Topics: Anxiety Disorders; Caffeine; Cocaine; Diet; Ethanol; Fear; Humans; Life Change Events; Marijuana Abuse; Nicotine; Nonprescription Drugs; Pain; Panic; Physical Exertion; Sleep Deprivation; Substance-Related Disorders | 1988 |
9 trial(s) available for nicotine and Ache
| Article | Year |
|---|---|
Pain characteristics and nicotine deprivation as predictors of performance during a laboratory paradigm of smoking cessation.
Topics: Adult; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Pain; Psychomotor Performance; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2020 |
Psychophysical and Vasomotor Responses of the Oral Tissues: A Nicotine Dose-Response and Menthol Interaction Study.
Topics: Adult; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Heart Rate; Humans; Irritants; Male; Menthol; Mouth; Nicotine; Pain; Pain Measurement; Pharynx; Regional Blood Flow; Thermosensing; Tobacco Use Cessation Devices; Tongue; Young Adult | 2016 |
A randomised double-blind crossover trial of the potential analgesic effect of a transdermal nicotine patch in non-smokers based on objective and subjective assessment.
Topics: Administration, Cutaneous; Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Nausea; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pain Threshold; Transdermal Patch | 2011 |
Olfactory and trigeminal interaction of menthol and nicotine in humans.
Topics: Adult; Analysis of Variance; Cross-Sectional Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Linear Models; Male; Menthol; Middle Aged; Nicotine; Nicotinic Agonists; Odorants; Olfactory Pathways; Pain; Pain Measurement; Physical Stimulation; Psychophysics; Rhinometry, Acoustic; Sensory Thresholds; Smell; Time Factors; Young Adult | 2012 |
Effects of nicotine on spinal cord injury pain vary among subtypes of pain and smoking status: results from a randomized, controlled experiment.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotine; Pain; Pain Measurement; Smoking; Spinal Cord Injuries; Treatment Outcome; Young Adult | 2012 |
The effects of cigarette smoking on pain and anxiety.
Topics: Adult; Anxiety; Cold Temperature; Humans; Male; Nicotine; Pain; Sensory Thresholds; Smoking; Tobacco Use Disorder | 1984 |
Acute tolerance to nicotine in smokers: lack of dissipation within 2 hours.
Topics: Adult; Animals; Drug Tolerance; Female; Fingers; Heart Rate; Hot Temperature; Humans; Male; Nicotine; Pain; Placebos; Self Medication; Smoking; Time Factors; Vasoconstriction | 1995 |
Pain inhibition, nicotine, and gender.
Topics: Administration, Cutaneous; Adult; Analgesics, Non-Narcotic; Electric Stimulation; Female; Humans; Male; Nicotine; Pain; Pain Measurement; Sex Characteristics | 1998 |
Nicotine-produced antinociception in minimally deprived smokers and ex-smokers.
Topics: Adult; Humans; Male; Nicotiana; Nicotine; Pain; Plants, Toxic; Reinforcement, Psychology; Sensory Thresholds; Substance Withdrawal Syndrome; Tobacco, Smokeless | 1986 |
101 other study(ies) available for nicotine and Ache
| Article | Year |
|---|---|
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.
Topics: Analgesics; Animals; Cells, Cultured; Disease Models, Animal; Ligands; Mice; Pain; Receptors, Nicotinic; Tetrahydroisoquinolines | 2004 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues. Novel nicotinic antagonist.
Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Mice; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2004 |
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Cell Line; Diamines; Dopamine; Heterocyclic Compounds, Bridged-Ring; In Vitro Techniques; Ligands; Models, Molecular; Nicotinic Agonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyridines; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2007 |
Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs.
Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Molecular Structure; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship | 2008 |
Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.
Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Mice; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2007 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues.
Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Contraindications; Female; Male; Mice; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pain; Patch-Clamp Techniques; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship; Xenopus | 2014 |
What Proportion of Active-duty Servicemembers Functionally Improve at 1 Year Post Hallux Valgus Correction?
Topics: Adult; Female; Hallux Valgus; Humans; Male; Middle Aged; Nicotine; Osteotomy; Pain; Retrospective Studies; Treatment Outcome | 2022 |
Adolescent nicotine exposure increases nociceptive behaviors in rat model of formalin test: Involvement of ventrolateral periaqueductal gray neurons.
Topics: Analgesics; Animals; Formaldehyde; Male; Morphine; Neurons; Nicotine; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar | 2022 |
Outcome of spine surgery in patients with depressed mental states: a Canadian spine outcome research network study.
Topics: Canada; Disability Evaluation; Humans; Lumbar Vertebrae; Nicotine; Pain; Prospective Studies; Quality of Life; Treatment Outcome | 2022 |
Longitudinal Associations Between Pain and Use of Cigarettes and E-cigarettes in the Population Assessment of Tobacco and Health (PATH) Study.
Topics: Adult; Cross-Sectional Studies; Electronic Nicotine Delivery Systems; Female; Humans; Longitudinal Studies; Nicotiana; Nicotine; Pain; Prospective Studies; Tobacco Products; Tobacco Use Disorder; Vaping | 2023 |
Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Humans; Inflammation; Mice; Mice, Transgenic; Nicotine; Osteoarthritis, Knee; Pain | 2023 |
The Effect of High Nicotine Dose on Maximum Anaerobic Performance and Perceived Pain in Healthy Non-Smoking Athletes: Crossover Pilot Study.
Topics: Adult; Anaerobiosis; Athletes; Cross-Sectional Studies; Humans; Nicotine; Pain; Pain Perception; Physical Exertion; Pilot Projects | 2023 |
Temporal associations between use of psychoactive substances and somatic symptoms in the daily lives of people with fibromyalgia.
Topics: Adult; Central Nervous System Agents; Female; Fibromyalgia; Humans; Male; Medically Unexplained Symptoms; Middle Aged; Nicotine; Pain; Substance-Related Disorders | 2023 |
Smokers with pain are more likely to report use of e-cigarettes and other nicotine products.
Topics: Adult; Cross-Sectional Studies; Electronic Nicotine Delivery Systems; Female; Humans; Longitudinal Studies; Male; Motivation; Nicotine; Pain; Smokers; Smoking Cessation | 2020 |
Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia.
Topics: Analgesia; Animals; Capsaicin; Cholinergic Neurons; Hyperalgesia; Male; Mecamylamine; Nicotine; Nociception; Nucleus Accumbens; Pain; Pain Management; Pain Measurement; Rats; Rats, Wistar; Stress, Psychological | 2020 |
Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats.
Topics: Analgesics, Opioid; Animals; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Humans; Motivation; Nicotine; Norepinephrine; Pain; Rats; Rats, Sprague-Dawley; Remifentanil; Selective Serotonin Reuptake Inhibitors; Self Administration; Serotonin; Stereoisomerism | 2020 |
Pain, nicotine, and tobacco smoking: current state of the science.
Topics: Humans; Nicotiana; Nicotine; Pain; Tobacco Smoking | 2020 |
Nicotine and sleep deprivation: impact on pain sensitivity and immune modulation in rats.
Topics: Animals; Hyperalgesia; Immunity; Interleukin-4; Interleukin-6; Male; Mecamylamine; Nicotine; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sleep Deprivation; Sleep, REM; Tumor Necrosis Factor-alpha | 2018 |
Menthol cigarette use and pain reporting among African American adults seeking treatment for smoking cessation.
Topics: Adult; Black or African American; Cigarette Smoking; Female; Humans; Male; Menthol; Middle Aged; Motivation; Nicotine; Pain; Smokers; Smoking Cessation; Tobacco Products | 2019 |
Nicotine inhibits rapamycin-induced pain through activating mTORC1/S6K/IRS-1-related feedback inhibition loop.
Topics: Analgesics; Animals; Insulin Receptor Substrate Proteins; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Nicotine; Pain; Pain Threshold; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Nicotinic; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2019 |
Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Line; Disease Models, Animal; Hyperalgesia; Inflammation; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nicotine; Osteoarthritis; Pain; Phosphatidylinositol 3-Kinases; RAW 264.7 Cells; Signal Transduction; Up-Regulation | 2019 |
Participation of central imidazoline binding sites in antinociceptive effect of ethanol and nicotine in rats.
Topics: Analgesics; Animals; Binding Sites; Brain; Dose-Response Relationship, Drug; Ethanol; Imidazoline Receptors; Injections, Intraventricular; Ligands; Male; Nicotine; Pain; Pain Measurement; Rats, Sprague-Dawley; Substance-Related Disorders | 2014 |
Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Constriction; Male; Nicotine; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Wounds and Injuries | 2013 |
Nicotine withdrawal and stress-induced changes in pain sensitivity: a cross-sectional investigation between abstinent smokers and nonsmokers.
Topics: Adult; Blood Pressure; Body Mass Index; Cross-Sectional Studies; Female; Heart Rate; Humans; Male; Nicotine; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Smoking Cessation; Stress, Psychological; Substance Withdrawal Syndrome; Young Adult | 2014 |
Effect of nicotine withdrawal on pain sensitivity in rats to mechanical stimulation and thermal stimulation.
Topics: Animals; Hot Temperature; Injections, Subcutaneous; Male; Nicotine; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Random Allocation; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2014 |
Effects of nicotinic acetylcholine receptor agonists in assays of acute pain-stimulated and pain-depressed behaviors in rats.
Topics: Acute Disease; Analgesics; Animals; Azetidines; Behavior, Animal; Benzamides; Brain; Bridged Bicyclo Compounds; Conditioning, Operant; Electric Stimulation; Male; Nicotine; Nicotinic Agonists; Pain; Pyridines; Rats, Sprague-Dawley; Self Stimulation | 2015 |
Peripheral nerve injury alters spinal nicotinic acetylcholine receptor pharmacology.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Male; Nicotine; Pain; Peripheral Nervous System Diseases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Spinal Nerves | 2008 |
Nicotine and postoperative management of pain.
Topics: Administration, Cutaneous; Analgesics; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Humans; Mice; Nicotine; Pain; Postoperative Period; Pyridines; Receptors, Cholinergic; Receptors, Nicotinic; Smoking; Spinal Cord | 2008 |
The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Carbamates; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Epilepsy; Evoked Potentials, Auditory; Exploratory Behavior; Hippocampus; Male; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Agonists; Pain; Pain Threshold; Quinuclidines; Rats; Receptors, Nicotinic; Sensory Gating; Social Behavior; Time Factors | 2009 |
Reduction of allodynia by intrathecal transplantation of microencapsulated porcine chromaffin cells.
Topics: Animals; Behavior, Animal; Catecholamines; Cattle; Cell- and Tissue-Based Therapy; Cells, Cultured; Cerebrospinal Fluid; Chromaffin Cells; Male; Models, Animal; Nicotine; Pain; Polylysine; Rats; Rats, Sprague-Dawley; Swine | 2009 |
Nicotinic acetylcholine receptors mediate the hypnotic and analgesic effects of emulsified inhalation anesthetics.
Topics: Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Emulsions; Enflurane; Female; Injections, Intraventricular; Injections, Spinal; Isoflurane; Male; Methyl Ethers; Mice; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pilot Projects; Receptors, Nicotinic; Sevoflurane | 2009 |
Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice.
Topics: Acetylcholine; Adenosine; Animals; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Hot Temperature; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Neostigmine; Nicotine; Obesity; Pain; Pain Measurement; Pons; Time Factors | 2009 |
Effects of intrathecal injection of nicotine on the analgesic effects of isoflurane in a model of inflammatory pain.
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Isoflurane; Mice; Nicotine; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Receptors, Nicotinic; Spinal Cord | 2009 |
Characterization of pharmacological and behavioral differences to nicotine in C57Bl/6 and DBA/2 mice.
Topics: Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Classical; Drug Tolerance; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Pain; Phenotype; Space Perception; Species Specificity; Substance Withdrawal Syndrome | 2009 |
The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.
Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Drug Interactions; Male; Morphine; Motor Activity; Nicotine; Pain; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2010 |
The effect of smoking on pain-related evoked potentials.
Topics: Adult; Analysis of Variance; Brain; Cotinine; Electroencephalography; Evoked Potentials; Heart Rate; Humans; Linear Models; Male; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Physical Stimulation; Smoking; Time Factors; Young Adult | 2010 |
Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Brain; Dose-Response Relationship, Drug; Hypothermia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motor Activity; Nicotine; Nicotinic Agonists; Pain; Pain Threshold; Protein Binding; Receptors, Nicotinic; Spinal Cord; Synaptosomes | 2010 |
Smoking and chronic pain: a real-but-puzzling relationship.
Topics: Chronic Disease; Humans; Nicotine; Pain; Pain Threshold; Risk Factors; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2011 |
Nicotine replacement therapy in critically ill patients: a prospective observational cohort study.
Topics: Adult; Aged; Critical Illness; Female; Hospital Mortality; Humans; Intensive Care Units; Male; Middle Aged; Nicotine; Pain; Prospective Studies; Psychomotor Agitation; Severity of Illness Index; Substance Withdrawal Syndrome | 2011 |
Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation.
Topics: Analgesics, Opioid; Animals; Corticosterone; Disease Models, Animal; Drug Administration Schedule; Fluorometry; Hypothalamo-Hypophyseal System; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Nicotinic Agonists; Pain; Pituitary-Adrenal System; Receptor Cross-Talk | 2011 |
A pervasive mechanism for analgesia: activation of GIRK2 channels.
Topics: Analgesia; Analgesics; Animals; Baclofen; Benzoxazines; Clonidine; Crosses, Genetic; Ethanol; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Mutagenesis; Naphthalenes; Nicotine; Oxotremorine; Pain; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Sex Characteristics | 2003 |
Effect of chlorpromazine on antidiuretic response to noxious stimuli.
Topics: Chlorpromazine; Diuresis; Histamine; Histamine Agents; Nicotine; Pain | 1958 |
Pain and inflammation induced by nicotine, acetylcholine and structurally related compounds and their prevention by desensitizing agents.
Topics: Acetylcholine; Humans; Inflammation; Nicotine; Ozone; Pain | 1961 |
Nicotine differentially activates inhibitory and excitatory neurons in the dorsal spinal cord.
Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Biomarkers; Calbindins; Dendrites; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neural Inhibition; Nicotine; Nociceptors; Pain; Posterior Horn Cells; Protein Subunits; Receptors, Neurokinin-1; Receptors, Nicotinic; RNA, Messenger; S100 Calcium Binding Protein G; Synaptic Transmission | 2004 |
Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat.
Topics: Animals; Female; Ganglia, Spinal; Male; Neurons; Nicotine; Pain; Rats; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger | 2004 |
Porcine chromaffin cells, culture, and transplant for antinociceptive effects in rodents and primates.
Topics: Animals; Behavior, Animal; Catecholamines; Cell Transplantation; Cells, Cultured; Chromaffin Cells; Chromatography, High Pressure Liquid; Enkephalins; Haplorhini; In Vitro Techniques; Male; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Swine; Time Factors; Transplantation, Heterologous | 2004 |
Nicotine as therapy.
Topics: Acetylcholine; Animals; Attention; Body Weight; Brain; Gene Expression Regulation; Humans; Models, Biological; Neurotransmitter Agents; Nicotiana; Nicotine; Oligonucleotide Array Sequence Analysis; Pain; Smoking; Substance-Related Disorders | 2004 |
The dorsal raphe nucleus as a site of action of the antinociceptive and behavioral effects of the alpha4 nicotinic receptor agonist epibatidine.
Topics: Analgesics; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Formaldehyde; Male; Microinjections; Motor Activity; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2005 |
Antinociceptive effect of nicotine in various pain models in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Pain; Pain Measurement | 2005 |
Nicotinic receptor involvement in antinociception induced by exposure to cigarette smoke.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mecamylamine; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Opioid, mu; Smoking | 2005 |
In vivo characterization of a novel inhibitor of CNS nicotinic receptors.
Topics: Analgesics; Animals; Body Temperature; Central Nervous System; Discrimination, Psychological; Dose-Response Relationship, Drug; Heptanoic Acids; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Pain; Pain Measurement; Piperidines; Rats; Rats, Long-Evans; Receptors, Nicotinic; Time Factors | 2005 |
Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Ligands; Male; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Norbornanes; Pain; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism | 2005 |
Persistent exercise attenuates nicotine- but not clonidine-induced antinociception in female rats.
Topics: Analgesia; Analgesics; Animals; Clonidine; Drug Tolerance; Female; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Physical Conditioning, Animal; Rats; Rats, Long-Evans; Receptors, Nicotinic | 2006 |
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.
Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Membrane; Male; Mecamylamine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Nicotine; Nicotinic Antagonists; Pain; Pyridines; Quinolizines; Reaction Time; Receptors, Nicotinic; Spinal Cord | 2007 |
Influence of nicotinic receptor modulators on CB2 cannabinoid receptor agonist (JWH133)-induced antinociception in mice.
Topics: Animals; Cannabinoids; Dose-Response Relationship, Drug; Formaldehyde; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Threshold; Receptor, Cannabinoid, CB2; Receptors, Nicotinic | 2007 |
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Down-Regulation; Dynorphins; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger | 2008 |
Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents.
Topics: Analysis of Variance; Animals; Behavior, Animal; Choline O-Acetyltransferase; Electric Stimulation; Ganglia, Spinal; Male; Neural Inhibition; Neurons, Afferent; Nicotine; Oligonucleotides, Antisense; Pain; Pain Measurement; Spinal Cord; Synaptic Transmission | 2007 |
Nicotine dependence criteria and nicotine withdrawal symptoms in relation to pain among an adult general population sample.
Topics: Adolescent; Adult; Alcoholism; Data Interpretation, Statistical; Female; Germany; Humans; Logistic Models; Male; Middle Aged; Nicotine; Nicotinic Agonists; Odds Ratio; Pain; Substance Withdrawal Syndrome; Tobacco Use Disorder; Young Adult | 2009 |
The effect of formalin pretreatment on nicotine-induced antinociceptive effect: the role of mu-opioid receptor in the hippocampus.
Topics: Acetic Acid; Analgesics; Animals; Benzoxazines; Blotting, Western; Brain; Coloring Agents; Drug Tolerance; Formaldehyde; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Oxazines; Pain; Pain Measurement; Receptors, Nicotinic; Receptors, Opioid, mu | 2008 |
Nicotinic nociceptors on perivascular sensory nerve endings.
Topics: Acetylcholine; Analgesics; Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Morphine; Nicotine; Nociceptors; Pain; Pilocarpine; Rabbits; Receptors, Cholinergic; Receptors, Nicotinic; Sensory Receptor Cells; Sensory Thresholds | 1982 |
Nicotine ingestion reduces elevated blood pressures in rats and squirrel monkeys.
Topics: Anger; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Male; Nicotine; Pain; Physical Stimulation; Rats; Saimiri | 1981 |
The role of skin nociceptive afferent nerves in blister healing.
Topics: Animals; Axons; Blister; Evoked Potentials; Neurons, Afferent; Neuropeptides; Nicotine; Nociceptors; Pain; Rats; Reflex; Skin; Wound Healing | 1993 |
Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord.
Topics: Afferent Pathways; Analgesics; Animals; Atropine; Blood Pressure; Electric Stimulation; Female; Injections, Intravenous; Injections, Spinal; Male; Mecamylamine; Nerve Fibers; Nicotine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Sural Nerve; Thalamic Nuclei | 1993 |
Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice.
Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Stereoisomerism | 1996 |
Nicotine enhances morphine- and beta-endorphin-induced antinociception at the supraspinal level in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Nociceptors; Pain; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Inherited, selective hyporesponsiveness to the analgesic action of nicotine in mice.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Genotype; Hot Temperature; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Nicotine; Pain; Pain Measurement; Reaction Time; Receptors, Nicotinic | 1996 |
Rectal response of cardiac origin in the cat: involvement of nitric oxide and acetylcholine.
Topics: Acetylcholine; Afferent Pathways; Animals; Arginine; Atropine; Blood Pressure; Cats; Coronary Vessels; Female; Ganglionic Blockers; Heart; Hexamethonium; Male; Muscle Contraction; Muscle Relaxation; Myocardial Ischemia; Neurotransmitter Agents; Nicotine; Nitric Oxide; Nitroarginine; Pain; Phentolamine; Propranolol; Rectum | 1997 |
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission | 1997 |
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Ligands; Mecamylamine; Morphine; Nerve Fibers; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Receptors, Nicotinic; Spinal Cord; Substance Withdrawal Syndrome; Synaptic Transmission | 1998 |
Sex differences in cocaine- and nicotine-induced antinociception in the rat.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Female; Hot Temperature; Male; Nicotine; Nicotinic Agonists; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Sex Characteristics | 1998 |
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists.
Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; Hindlimb; Hot Temperature; Injections, Spinal; Lobeline; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Pain; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine; Vocalization, Animal | 1998 |
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits.
Topics: Analgesia; Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Neurons; Nicotine; Nicotinic Agonists; Pain; Pyridines; Raphe Nuclei; Receptors, Nicotinic; Spinal Cord; Thalamus | 1999 |
Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.
Topics: Animals; Body Temperature; Bupropion; Cocaine; Discrimination, Psychological; Female; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Molecular Structure; Motor Activity; Nicotine; Oocytes; Pain; Piperazines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recombinant Proteins; Seizures; Structure-Activity Relationship; Tropanes; Xenopus laevis | 1999 |
Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine.
Topics: Action Potentials; Animals; Azetidines; Histamine; Histamine H1 Antagonists; Hot Temperature; Male; Mecamylamine; Microinjections; Narcotic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Stimulation, Chemical; Tachyphylaxis | 1999 |
The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain.
Topics: Analgesics; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Humans; Models, Molecular; Neurons; Nicotine; Nicotinic Agonists; Pain; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2000 |
Role of neuronal nicotinic-acetylcholine receptors in the activation of neurons in trigeminal subnucleus caudalis by nicotine delivered to the oral mucosa.
Topics: Administration, Oral; Animals; Atropine; Male; Mecamylamine; Mouth Mucosa; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tachyphylaxis; Tongue; Trigeminal Caudal Nucleus | 2000 |
Cross-desensitization of capsaicin-evoked oral irritation by high but not low concentrations of nicotine in human subjects.
Topics: Adult; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Nicotine; Nociceptors; Pain; Tongue | 2000 |
The involvement of spinal Ca(2+)/calmodulin-protein kinase II in nicotine-induced antinociception in mice.
Topics: Analgesics; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Interactions; Enzyme Inhibitors; Male; Mice; Nicotine; Nimodipine; Pain; Pain Measurement; Spinal Cord; Synaptosomes | 2000 |
The analgesic potential of intraventricular polymer-encapsulated adrenal chromaffin cells in a rodent model of chronic neuropathic pain.
Topics: Adrenal Glands; Analgesics; Animals; Cattle; Cell Transplantation; Chromaffin Cells; Chronic Disease; Disease Models, Animal; Ganglionic Stimulants; Hand Strength; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Nicotine; Pain; Pain Management; Polymers; Rats; Rats, Sprague-Dawley; Touch | 2000 |
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Fixatives; Formaldehyde; Ganglionic Stimulants; Inflammation; Magnesium Sulfate; Mice; Mice, Transgenic; Morphine; Naloxone; Narcotic Antagonists; Nicotine; Opioid-Related Disorders; Pain; Substance Withdrawal Syndrome | 2001 |
Analgesia induced by chronic nicotine infusion in rats: differences by gender and pain test.
Topics: Analgesics, Non-Narcotic; Animals; Body Weight; Female; Male; Nicotine; Pain; Rats; Rats, Sprague-Dawley; Sex Factors | 2001 |
Analgesic and toxic effects of neonicotinoid insecticides in mice.
Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Fibroblasts; Imidazoles; Insecticides; Mecamylamine; Mice; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Thiazines; Time Factors | 2001 |
Effects of nicotine, mecamylamine, and hexamethonium on shock-induced fighting, pain reactivity, and locomotor behaviour in rats.
Topics: Aggression; Animals; Electroshock; Hexamethonium Compounds; Humans; Male; Mecamylamine; Motor Activity; Nicotine; Pain; Rats | 1979 |
Chemosensitive spinal afferents: thresholds of specific and nociceptive reflexes as compared with thresholds of excitation for receptors and axons.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Carbachol; Cats; Chemoreceptor Cells; Histamine; Humans; Intestine, Small; Methacholine Compounds; Neurons, Afferent; Nicotine; Pain; Pilocarpine; Potassium; Reflex; Serotonin; Spinal Cord; Spinal Nerve Roots | 1976 |
Nicotine enhances angina pectoris-like chest pain and atrioventricular blockade provoked by intravenous bolus of adenosine in healthy volunteers.
Topics: Adenosine; Adult; Angina Pectoris; Drug Synergism; Electrocardiography; Female; Heart Block; Heart Rate; Humans; Male; Middle Aged; Nicotine; Pain | 1990 |
Effect of pCPA on nicotine-induced analgesia.
Topics: Analgesia; Animals; Drug Interactions; Fenclonine; Male; Mecamylamine; Naloxone; Nicotine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds | 1990 |
Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats.
Topics: Analgesia; Animals; Injections, Spinal; Male; Mecamylamine; Nicotine; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stereoisomerism; Yohimbine | 1990 |
Inhibition by neosurugatoxin of nicotine-induced antinociception.
Topics: Animals; Central Nervous System; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Mice; Mollusk Venoms; Nicotine; Pain; Pempidine; Receptors, Nicotinic | 1986 |
Alpha-2 receptor blockade increases responsiveness of locus coeruleus neurons to excitatory stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Idazoxan; Injections, Intravenous; Locus Coeruleus; Male; Neurons; Nicotine; Pain; Physical Stimulation; Rats; Rats, Inbred Strains; Yohimbine | 1987 |
Analgesia induced by isolated bovine chromaffin cells implanted in rat spinal cord.
Topics: Analgesia; Animals; Chromaffin System; Naloxone; Nicotine; Pain; Rats; Spinal Cord; Subarachnoid Space | 1986 |
Morphological and functional correlates of chromaffin cell transplants in CNS pain modulatory regions.
Topics: Adrenal Medulla; Analgesia; Animals; Cattle; Chromaffin Granules; Female; Male; Microscopy, Electron; Nicotine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Transplantation, Heterologous | 1987 |
Alterations in nociception following adrenal medullary transplants into the rat periaqueductal gray.
Topics: Adrenal Medulla; Adrenergic Fibers; Animals; Endorphins; Female; Male; Naloxone; Nicotine; Pain; Periaqueductal Gray; Phentolamine; Rats; Rats, Inbred Strains | 1987 |
The spinal cord as a major site for the antinociceptive action of nicotine in the rat.
Topics: Analgesia; Animals; Carotid Arteries; Injections, Intra-Arterial; Injections, Intraventricular; Injections, Subcutaneous; Male; Nicotine; Nociceptors; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Subarachnoid Space; Vertebral Artery | 1986 |
Adrenal medullary tissue transplants in the rat spinal cord reduce pain sensitivity.
Topics: Adrenal Medulla; Analgesia; Animals; Chromaffin Granules; Endorphins; Female; Hot Temperature; Microscopy, Electron; Naloxone; Nicotine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Subarachnoid Space; Time Factors | 1986 |
Synthesis and pharmacological action of some N-alkyl morpholines and their salts.
Topics: Acetylcholine; Animals; Female; Magnetic Resonance Spectroscopy; Mice; Morpholines; Nicotine; Pain; Pentylenetetrazole; Seizures; Spectrophotometry; Ultraviolet Rays | 1968 |
[The "paw flick" test, using a modified burning ray method for analgesimedric studies on rats under special circumstances].
Topics: Animals; Arecoline; Avoidance Learning; Escape Reaction; Hindlimb; Nicotine; Pain; Radiation Injuries, Experimental; Rats; Reaction Time; Reactive Inhibition; Tail | 1974 |
Green-tobacco sickness. An illness of tobacco harvesters.
Topics: Abdomen; Adolescent; Agricultural Workers' Diseases; Environmental Exposure; Female; Headache; Humans; Humidity; Male; Nausea; Nicotiana; Nicotine; North Carolina; Occupations; Pain; Pallor; Plants, Toxic; Salivation; Seasons; Smoking; Sweating; Time Factors; Vomiting | 1974 |
Smoking, physiological arousal, and emotional response.
Topics: Adolescent; Adult; Arousal; Differential Threshold; Electroshock; Emotions; Humans; Male; Nicotiana; Nicotine; Pain; Plants, Toxic; Pulse; Smoking | 1973 |
Antin ociceptive activity of nicotine.
Topics: Acetates; Analgesia; Animals; Dimethylphenylpiperazinium Iodide; Drug Tolerance; Injections, Intraperitoneal; Mecamylamine; Methods; Mice; Nicotine; Oxotremorine; Pain; Physostigmine; Rats; Reaction Time; Seizures; Tremorine | 1973 |
[Correlation between the chemical structure and algogenic activity of some vasoactive substances].
Topics: Amphetamine; Animals; Nicotine; Pain; Peptides; Rats; Vasoconstrictor Agents; Vasodilator Agents | 1968 |
The action of nicotine on the blood vessels of the hand and forearm in man.
Topics: Anesthesia, Conduction; Arm; Blood Flow Velocity; Blood Vessels; Denervation; Hand; Hexamethonium Compounds; Humans; Injections, Intra-Arterial; Male; Nicotine; Pain; Phenoxybenzamine; Reflex; Scopolamine; Sympathectomy; Sympathetic Nervous System; Sympatholytics | 1966 |