Page last updated: 2024-08-26

nicotine and Ache

nicotine has been researched along with Ache in 123 studies

Research

Studies (123)

TimeframeStudies, this research(%)All Research%
pre-199023 (18.70)18.7374
1990's18 (14.63)18.2507
2000's42 (34.15)29.6817
2010's25 (20.33)24.3611
2020's15 (12.20)2.80

Authors

AuthorsStudies
Dahdouh, A; Damaj, MI; Dukat, M; Glennon, RA; Martin, BR; Siripurapu, U; Taroua, M1
Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Navarro, HA; Ware, R1
Anderson, DJ; Barlocco, D; Buckley, M; Bunnelle, WH; Cao, YJ; Curzon, P; Daanen, JF; Dart, MJ; Frost, JM; Gelain, A; Ji, J; Meyer, MD; Putman, CB; Puttfarcken, P; Ryther, KB; Schrimpf, MR; Searle, X; Surowy, C; Toma, L1
Brieaddy, LE; Burgess, JP; Damaj, MI; Ivy Carroll, F; Lee, JR; Ma, W; Martin, BR; Navarro, HA; Yokota, Y1
Atkinson, RN; Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Mascarella, SW; Navarro, HA; Robinson, TP1
Baraldi, PG; Geppetti, P; Materazzi, S; Preti, D1
Bartkowiak, JM; Carroll, FI; Castro, AH; Damaj, MI; Luetje, CW; Mascarella, SW; Navarro, HA; Ondachi, PW1
Bi, YZ; Hu, L; Kong, YZ; Lu, ZJ; Zhong, JH1
Albin Nielsen, K; Arendt-Nielsen, L; Boucher, Y; Carstens, E; Clavé, P; Nielsen, TA; Proctor, G; Reeh, PW1
Baynes, T; Dowd, T; Huh, J; Nicholes, M; Schroeder, P1
Azizi, H; Khalouzadeh, F; Semnanian, S1
Abraham, E; Ahn, H; Attabib, N; Bailey, CS; Christie, S; Cushnie, D; Dea, N; Finkelstein, J; Fisher, C; Glennie, A; Hall, H; Johnson, M; Kelly, A; Manson, N; Nataraj, A; Paquet, J; Rampersaud, R; Soroceanu, A; Stratton, A; Thomas, K; Weber, MH1
Ditre, JW; Heckman, BW; Maisto, SA; Powers, JM; Zvolensky, MJ1
Berenbaum, F; Courties, A; Head, SR; Lotz, MK; Myers, K; Natarajan, P; Olmer, M; Ordoukhanian, P; Sellam, J1
Bartík, P; Petrů, D; Pyšná, J; Pyšný, L; Šagát, P; Suchý, J; Trubák, Z1
Kratz, AL; Kuzu, D; Valentine, TR1
Ditre, JW; Heckman, BW; LaRowe, LR; Powers, JM2
Andersen, EOL; Fischer, L; Gaspar, JC; Guilhen, VA; Lazzarim, MK; Polato, JJ; Sardi, NF; Tobaldini, G1
Blair, G; Hawkey, A; Holloway, Z; Ko, A; Levin, ED; McKinney, A; Modarres, J; Pace, C; Rezvani, AH; Rose, JE; Vierling, A; Wells, C1
Ditre, JW; LaRowe, LR1
Balayssac, D1
Andersen, ML; Berro, LF; Hirotsu, C; Pedroni, MN; Tufik, S1
Khakpai, F; Zarrindast, MR1
Buckner, JD; Ditre, JW; Hughes, MT; Kosiba, JD; LaRowe, LR; Norton, PJ; Smits, JAJ; Zvolensky, MJ1
Cheng, L; Feng, B; Guan, S; Li, S; Tian, Z; Wang, X; Wang, Y; Yang, Q; Zhao, M1
Dai, Y; Hu, J; Liu, WT; Liu, Y; Teng, P; Zhang, H1
Aglawe, MM; Chopde, CT; Kotagale, NR; Kuldhariya, SS; Taksande, BG; Umekar, MJ1
Di Cesare Mannelli, L; Ghelardini, C; Zanardelli, M1
Marks, MJ1
Al'Absi, M; Nakajima, M1
Liu, XW; Liu, Z; Lu, SF; Yu, AL; Zhang, ZW1
Arendt Nielsen, T; Arendt-Nielsen, L; Boudreau, SA; Nielsen, BP; Wang, K1
Carroll, FI; Freitas, KC; Negus, SS1
Ditre, JW; Heckman, BW; Kosiba, JD; Maisto, SA; Zale, EL1
Parker, R; Vincler, M; Wittenauer, S; Young, T1
Benowitz, NL1
Bilbe, G; Chaperon, F; Enz, A; Feuerbach, D; Gentsch, C; Hoyer, D; Lingenhoehl, K; McAllister, K; Nozulak, J; Olpe, HR; Vassout, A1
Baek, WY; Kim, YM; Kwak, KH; Lim, JO1
Dai, TJ; Yan, S; Zeng, YM1
Bertrand, D; D'hoedt, D1
Baghdoyan, HA; Lydic, R; Wang, W1
Chen, HS; Cheng, W; Feng, T; Wang, S; Yin, Q; Zeng, YM1
Damaj, MI; Jackson, KJ; Martin, BR; Miles, MF; Walters, CL1
Crooks, PA; Holtman, JR; Johnson-Hardy, JK; Wala, EP1
Eccleston, C; Keogh, E; Moore, DJ1
Domino, EF; Inui, K; Kakigi, R; Miyazaki, T; Wang, X1
Chen, X; Damaj, MI; Gamage, TF; Jackson, KJ; Marks, MJ; Vann, RE; Warner, JA1
Hooten, WM; Mantilla, CB; Shi, Y; Warner, DO; Weingarten, TN2
Afessa, B; Cartin-Ceba, R; Hays, JT; Warner, DO1
Fukada, T; Iwakiri, H; Ozaki, M1
Kiguchi, N; Kishioka, S; Kobayashi, Y; Maeda, T; Ueno, K; Yamamoto, A; Yamamoto, C1
Renner, B; Schreiber, K1
Ness, TJ; Redden, DT; Richards, JS; Richardson, EJ; Stewart, CC1
Alva, H; Blednov, YA; Harris, RA; Stoffel, M1
DE WIED, D; JINKS, R1
JANCSO, N; JANCSO-GABOR, A; TAKATS, I1
Changeux, JP; Cordero-Erausquin, M; Faure, P; Pons, S1
Bernardini, N; Haberberger, RV; Hartmann, P; Kress, M; Kummer, W; Lips, KS1
Jing, R; Lu, Y; Pappas, GD; Yeomans, DC1
Powledge, TM1
Chaijale, N; Commons, KG; Cucchiaro, G1
Choi, SS; Han, KJ; Kwon, MS; Lee, HK; Lee, JY; Seo, YJ; Shim, EJ; Suh, HW1
Carstens, E; Carstens, MI; Cuellar, JM; Moore, JA; Pinkerton, KE; Simons, CT; Uyeminami, D1
Damaj, MI; Martin, BR; Papke, RL; Wiley, JL1
Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Navarro, HA1
Karsak, M; Valverde, O; Zimmer, A1
Kanarek, RB; Mathes, WF1
Collins, AC; Damaj, MI; Deshpande, P; Fonck, C; Labarca, C; Lester, HA; Marks, MJ; Martin, BR1
Djahanguiri, B; Ghiasvand, F; Golmohammadi, S; Jafari, MR; Zarrindast, MR1
Kiguchi, N; Kishioka, S; Maeda, T; Ozaki, M; Tsuruga, M; Yamamoto, A; Yamamoto, C1
Inoue, M; Matsumoto, M; Ueda, H; Xie, W1
Hapke, U; John, U; Meyer, C; Rumpf, HJ1
Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Suh, HW1
Fertig, JB; Pomerleau, OF; Turk, DC1
Juan, H1
Emley, GS; Hutchinson, RR1
Caggiula, A; Goettler, J; Grobe, JE; Mitchell, SL; Perkins, KA; Scierka, A; Stiller, RL1
Carr, RW; Delaney, CA; Morris, MJ; Roberts, RG; Westerman, RA1
Baldauf, J; Jurna, I; Krauss, P1
Damaj, MI; Martin, BR1
Choi, SR; Chung, KM; Kim, YH; Song, DK; Suh, HW1
Basmadjian, G; Nael, R; Seale, TW1
Basak, AK; Das, M; Koley, B; Koley, J; Sinha, S1
Arneric, SP; Donnelly-Roberts, DL; Manelli, AM; Puttfarcken, PS1
Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M1
Girdler, SS; Jamner, LD; Jarvik, ME; Shapiro, D1
Craft, RM; Milholland, RB1
Buerkle, H; Khan, IM; Taylor, P; Yaksh, TL1
Changeux, JP; Cordero-Erausquin, M; Damaj, MI; de Kerchove d'Exaerde, A; del Mar Arroyo-Jimenez, M; Huchet, M; Le Novère, N; Léna, C; Marubio, LM1
Carroll, FI; Damaj, MI; Martin, BR; Slemmer, JE1
Carstens, E; Jinks, SL1
Anderson, DJ; Dart, MJ; Decker, MW; Kim, KH; Meyer, MD; Rueter, LE; Sullivan, JP; Williams, M1
Carstens, E; Carstens, MI; Dessirier, JM; Jinks, SL; Simons, CT1
Carstens, E; Chang, HK; Dessirier, JM; O'Mahony, M1
Damaj, MI1
Emerich, DF; Francis, JM; Frydel, BR; Lindner, MD; McDermott, PE; Plone, MA; Saydoff, JA1
Changeux, JP; Damaj, MI; Epping-Jordan, MP; Marubio, LM; Merlo-Pich, E; Salmon, AM1
Dickerson, ED; Ripamonti, C1
Anderson, KA; Carstens, E; Carstens, MI; Jinks, SL; Simons, CT1
Casida, JE; Cowan, A; Tomizawa, M1
Rodgers, RJ1
Baraz, LA; Chernilovskaya, PE; Khayutin, VM; Lukoshkova, EV; Sonina, RS1
Beermann, B; Jonzon, B; Kaijser, L; Sylvén, C1
Cooley, JE; Fowler, SC; Lombardo, TW; Moss, RA; Sult, S; Villarosa, GA1
Christensen, MK; Smith, DF1
Hayashi, E; Kagawa, Y; Kosuge, T; Takayanagi, N; Tsuji, K; Yamada, S1
Simson, PE; Weiss, JM1
Roy-Byrne, PP; Uhde, TW1
Pappas, GD; Pollard, HB; Sagen, J1
Pappas, GD; Sagen, J1
Pappas, GD; Perlow, MJ; Sagen, J2
Fertig, JB; Pomerleau, OF; Sanders, B1
Aceto, MD; Bagley, RS; Dewey, WL; Fu, TC; Martin, BR1
Beckett, AH; Hunter, WH; Kourounakis, P1
Andreas, K; Dude, C; Queck, KH1
Gehlbach, SH; Perry, LD; Williams, WA; Woodall, JS1
Nesbitt, PD1
Bite, A; Dóda, M; György, L; Phan, DV1
Deffenu, G1
Fewings, JD; Rand, MJ; Scroop, GC; Whelan, RF1

Reviews

13 review(s) available for nicotine and Ache

ArticleYear
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
    Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asthma; Humans; Ion Channel Gating; Neurons; Pain; Peripheral Nervous System Diseases; Pulmonary Disease, Chronic Obstructive; Transient Receptor Potential Channels

2010
[Central neural mechanism of increased pain sensitivity induced by nicotine abstinence].
    Sheng li xue bao : [Acta physiologica Sinica], 2021, Dec-25, Volume: 73, Issue:6

    Topics: Animals; Humans; Nicotine; Pain; Pain Threshold; Smoking Cessation; Tobacco Use Disorder

2021
The Role of TRP Channels in Nicotinic Provoked Pain and Irritation from the Oral Cavity and Throat: Translating Animal Data to Humans.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2022, 11-12, Volume: 24, Issue:12

    Topics: Animals; Humans; Mouth; Nicotine; Nicotinic Agonists; Pain; Pharynx; Smoking Cessation; Tobacco Use Cessation Devices; Transient Receptor Potential Channels

2022
[Relation between tobacco smoking and pain: A narrative review of the scientific literature].
    Revue des maladies respiratoires, 2021, Volume: 38, Issue:3

    Topics: Humans; Nicotine; Pain; Smoking; Smoking Cessation; Tobacco Smoking

2021
The modulatory role of nicotine on cognitive and non-cognitive functions.
    Brain research, 2019, 05-01, Volume: 1710

    Topics: Animals; Anxiety; Body Temperature; Body Weight; Brain; Cognition; Humans; Learning; Nicotine; Nicotinic Agonists; Pain; Receptors, Nicotinic; Reward; Substance-Related Disorders

2019
Genetic matters: thirty years of progress using mouse models in nicotinic research.
    Biochemical pharmacology, 2013, Oct-15, Volume: 86, Issue:8

    Topics: Animals; Gene Expression Regulation; Genetic Variation; Nicotine; Pain; Receptors, Nicotinic

2013
Acute analgesic effects of nicotine and tobacco in humans: a meta-analysis.
    Pain, 2016, Volume: 157, Issue:7

    Topics: Analgesics; Humans; Nicotiana; Nicotine; Pain; Pain Threshold

2016
Nicotinic acetylcholine receptors: an overview on drug discovery.
    Expert opinion on therapeutic targets, 2009, Volume: 13, Issue:4

    Topics: Allosteric Regulation; Analgesics; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular Diseases; Drug Discovery; Hearing; Humans; Myasthenia Gravis; Neurodegenerative Diseases; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Protein Subunits; Psoriasis; Pyridines; Receptors, Nicotinic; Schizophrenia; Smoking; Smoking Cessation; Tobacco Use Disorder

2009
Identifying experimental methods to determine the effect of pain on attention: a review of pain, caffeine, alcohol and nicotine studies.
    Human psychopharmacology, 2009, Volume: 24, Issue:8

    Topics: Adult; Attention; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Ethanol; Humans; Nicotine; Nicotinic Agonists; Pain; Psychomotor Performance

2009
Smoking and pain: pathophysiology and clinical implications.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Animals; Chronic Disease; Depression; Female; Humans; Ligands; Male; Nicotine; Nicotinic Agonists; Pain; Pain, Postoperative; Receptors, Nicotinic; Risk Factors; Smoking; Smoking Cessation; Treatment Outcome

2010
Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice.
    Handbook of experimental pharmacology, 2005, Issue:168

    Topics: Animals; Cannabinoid Receptor Modulators; Cognition; Drug Interactions; Emotions; Endocannabinoids; Ethanol; Feeding Behavior; Humans; Locomotion; Marijuana Abuse; Mice; Mice, Knockout; Narcotics; Nicotine; Pain; Receptor, Cannabinoid, CB1

2005
Strategies for the treatment of cancer pain in the new millennium.
    Drugs, 2001, Volume: 61, Issue:7

    Topics: Analgesics, Opioid; Cannabinoids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Methadone; Morphine; Neoplasms; Nicotine; Pain

2001
Exogenous factors in panic disorder: clinical and research implications.
    The Journal of clinical psychiatry, 1988, Volume: 49, Issue:2

    Topics: Anxiety Disorders; Caffeine; Cocaine; Diet; Ethanol; Fear; Humans; Life Change Events; Marijuana Abuse; Nicotine; Nonprescription Drugs; Pain; Panic; Physical Exertion; Sleep Deprivation; Substance-Related Disorders

1988

Trials

9 trial(s) available for nicotine and Ache

ArticleYear
Pain characteristics and nicotine deprivation as predictors of performance during a laboratory paradigm of smoking cessation.
    Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2020, Volume: 34, Issue:2

    Topics: Adult; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Pain; Psychomotor Performance; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder

2020
Psychophysical and Vasomotor Responses of the Oral Tissues: A Nicotine Dose-Response and Menthol Interaction Study.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016, Volume: 18, Issue:5

    Topics: Adult; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Heart Rate; Humans; Irritants; Male; Menthol; Mouth; Nicotine; Pain; Pain Measurement; Pharynx; Regional Blood Flow; Thermosensing; Tobacco Use Cessation Devices; Tongue; Young Adult

2016
A randomised double-blind crossover trial of the potential analgesic effect of a transdermal nicotine patch in non-smokers based on objective and subjective assessment.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:8

    Topics: Administration, Cutaneous; Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Nausea; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pain Threshold; Transdermal Patch

2011
Olfactory and trigeminal interaction of menthol and nicotine in humans.
    Experimental brain research, 2012, Volume: 219, Issue:1

    Topics: Adult; Analysis of Variance; Cross-Sectional Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Linear Models; Male; Menthol; Middle Aged; Nicotine; Nicotinic Agonists; Odorants; Olfactory Pathways; Pain; Pain Measurement; Physical Stimulation; Psychophysics; Rhinometry, Acoustic; Sensory Thresholds; Smell; Time Factors; Young Adult

2012
Effects of nicotine on spinal cord injury pain vary among subtypes of pain and smoking status: results from a randomized, controlled experiment.
    The journal of pain, 2012, Volume: 13, Issue:12

    Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotine; Pain; Pain Measurement; Smoking; Spinal Cord Injuries; Treatment Outcome; Young Adult

2012
The effects of cigarette smoking on pain and anxiety.
    Addictive behaviors, 1984, Volume: 9, Issue:3

    Topics: Adult; Anxiety; Cold Temperature; Humans; Male; Nicotine; Pain; Sensory Thresholds; Smoking; Tobacco Use Disorder

1984
Acute tolerance to nicotine in smokers: lack of dissipation within 2 hours.
    Psychopharmacology, 1995, Volume: 118, Issue:2

    Topics: Adult; Animals; Drug Tolerance; Female; Fingers; Heart Rate; Hot Temperature; Humans; Male; Nicotine; Pain; Placebos; Self Medication; Smoking; Time Factors; Vasoconstriction

1995
Pain inhibition, nicotine, and gender.
    Experimental and clinical psychopharmacology, 1998, Volume: 6, Issue:1

    Topics: Administration, Cutaneous; Adult; Analgesics, Non-Narcotic; Electric Stimulation; Female; Humans; Male; Nicotine; Pain; Pain Measurement; Sex Characteristics

1998
Nicotine-produced antinociception in minimally deprived smokers and ex-smokers.
    Addictive behaviors, 1986, Volume: 11, Issue:3

    Topics: Adult; Humans; Male; Nicotiana; Nicotine; Pain; Plants, Toxic; Reinforcement, Psychology; Sensory Thresholds; Substance Withdrawal Syndrome; Tobacco, Smokeless

1986

Other Studies

101 other study(ies) available for nicotine and Ache

ArticleYear
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.
    Bioorganic & medicinal chemistry letters, 2004, Jul-16, Volume: 14, Issue:14

    Topics: Analgesics; Animals; Cells, Cultured; Disease Models, Animal; Ligands; Mice; Pain; Receptors, Nicotinic; Tetrahydroisoquinolines

2004
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues. Novel nicotinic antagonist.
    Journal of medicinal chemistry, 2004, Aug-26, Volume: 47, Issue:18

    Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Mice; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2004
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
    Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15

    Topics: Analgesics; Animals; Binding, Competitive; Brain; Cell Line; Diamines; Dopamine; Heterocyclic Compounds, Bridged-Ring; In Vitro Techniques; Ligands; Models, Molecular; Nicotinic Agonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyridines; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2007
Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs.
    Bioorganic & medicinal chemistry, 2008, Jan-15, Volume: 16, Issue:2

    Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Molecular Structure; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship

2008
Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.
    Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25

    Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Mice; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2007
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues.
    Journal of medicinal chemistry, 2014, Feb-13, Volume: 57, Issue:3

    Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Contraindications; Female; Male; Mice; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pain; Patch-Clamp Techniques; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship; Xenopus

2014
What Proportion of Active-duty Servicemembers Functionally Improve at 1 Year Post Hallux Valgus Correction?
    Clinical orthopaedics and related research, 2022, 11-01, Volume: 480, Issue:11

    Topics: Adult; Female; Hallux Valgus; Humans; Male; Middle Aged; Nicotine; Osteotomy; Pain; Retrospective Studies; Treatment Outcome

2022
Adolescent nicotine exposure increases nociceptive behaviors in rat model of formalin test: Involvement of ventrolateral periaqueductal gray neurons.
    Life sciences, 2022, Jun-15, Volume: 299

    Topics: Analgesics; Animals; Formaldehyde; Male; Morphine; Neurons; Nicotine; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar

2022
Outcome of spine surgery in patients with depressed mental states: a Canadian spine outcome research network study.
    The spine journal : official journal of the North American Spine Society, 2022, Volume: 22, Issue:10

    Topics: Canada; Disability Evaluation; Humans; Lumbar Vertebrae; Nicotine; Pain; Prospective Studies; Quality of Life; Treatment Outcome

2022
Longitudinal Associations Between Pain and Use of Cigarettes and E-cigarettes in the Population Assessment of Tobacco and Health (PATH) Study.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2023, 02-09, Volume: 25, Issue:3

    Topics: Adult; Cross-Sectional Studies; Electronic Nicotine Delivery Systems; Female; Humans; Longitudinal Studies; Nicotiana; Nicotine; Pain; Prospective Studies; Tobacco Products; Tobacco Use Disorder; Vaping

2023
Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours.
    Annals of the rheumatic diseases, 2023, Volume: 82, Issue:5

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Humans; Inflammation; Mice; Mice, Transgenic; Nicotine; Osteoarthritis, Knee; Pain

2023
The Effect of High Nicotine Dose on Maximum Anaerobic Performance and Perceived Pain in Healthy Non-Smoking Athletes: Crossover Pilot Study.
    International journal of environmental research and public health, 2023, 01-05, Volume: 20, Issue:2

    Topics: Adult; Anaerobiosis; Athletes; Cross-Sectional Studies; Humans; Nicotine; Pain; Pain Perception; Physical Exertion; Pilot Projects

2023
Temporal associations between use of psychoactive substances and somatic symptoms in the daily lives of people with fibromyalgia.
    Pain medicine (Malden, Mass.), 2023, 10-03, Volume: 24, Issue:10

    Topics: Adult; Central Nervous System Agents; Female; Fibromyalgia; Humans; Male; Medically Unexplained Symptoms; Middle Aged; Nicotine; Pain; Substance-Related Disorders

2023
Smokers with pain are more likely to report use of e-cigarettes and other nicotine products.
    Experimental and clinical psychopharmacology, 2020, Volume: 28, Issue:5

    Topics: Adult; Cross-Sectional Studies; Electronic Nicotine Delivery Systems; Female; Humans; Longitudinal Studies; Male; Motivation; Nicotine; Pain; Smokers; Smoking Cessation

2020
Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia.
    Behavioural pharmacology, 2020, Volume: 31, Issue:2&3

    Topics: Analgesia; Animals; Capsaicin; Cholinergic Neurons; Hyperalgesia; Male; Mecamylamine; Nicotine; Nociception; Nucleus Accumbens; Pain; Pain Management; Pain Measurement; Rats; Rats, Wistar; Stress, Psychological

2020
Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats.
    Psychopharmacology, 2020, Volume: 237, Issue:6

    Topics: Analgesics, Opioid; Animals; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Humans; Motivation; Nicotine; Norepinephrine; Pain; Rats; Rats, Sprague-Dawley; Remifentanil; Selective Serotonin Reuptake Inhibitors; Self Administration; Serotonin; Stereoisomerism

2020
Pain, nicotine, and tobacco smoking: current state of the science.
    Pain, 2020, Volume: 161, Issue:8

    Topics: Humans; Nicotiana; Nicotine; Pain; Tobacco Smoking

2020
Nicotine and sleep deprivation: impact on pain sensitivity and immune modulation in rats.
    Scientific reports, 2018, 09-14, Volume: 8, Issue:1

    Topics: Animals; Hyperalgesia; Immunity; Interleukin-4; Interleukin-6; Male; Mecamylamine; Nicotine; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sleep Deprivation; Sleep, REM; Tumor Necrosis Factor-alpha

2018
Menthol cigarette use and pain reporting among African American adults seeking treatment for smoking cessation.
    Experimental and clinical psychopharmacology, 2019, Volume: 27, Issue:3

    Topics: Adult; Black or African American; Cigarette Smoking; Female; Humans; Male; Menthol; Middle Aged; Motivation; Nicotine; Pain; Smokers; Smoking Cessation; Tobacco Products

2019
Nicotine inhibits rapamycin-induced pain through activating mTORC1/S6K/IRS-1-related feedback inhibition loop.
    Brain research bulletin, 2019, Volume: 149

    Topics: Analgesics; Animals; Insulin Receptor Substrate Proteins; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Nicotine; Pain; Pain Threshold; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Nicotinic; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2019
Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor.
    Journal of immunology (Baltimore, Md. : 1950), 2019, 07-15, Volume: 203, Issue:2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Line; Disease Models, Animal; Hyperalgesia; Inflammation; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nicotine; Osteoarthritis; Pain; Phosphatidylinositol 3-Kinases; RAW 264.7 Cells; Signal Transduction; Up-Regulation

2019
Participation of central imidazoline binding sites in antinociceptive effect of ethanol and nicotine in rats.
    Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:3

    Topics: Analgesics; Animals; Binding Sites; Brain; Dose-Response Relationship, Drug; Ethanol; Imidazoline Receptors; Injections, Intraventricular; Ligands; Male; Nicotine; Pain; Pain Measurement; Rats, Sprague-Dawley; Substance-Related Disorders

2014
Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models.
    European journal of pharmacology, 2013, Jul-05, Volume: 711, Issue:1-3

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Constriction; Male; Nicotine; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Wounds and Injuries

2013
Nicotine withdrawal and stress-induced changes in pain sensitivity: a cross-sectional investigation between abstinent smokers and nonsmokers.
    Psychophysiology, 2014, Volume: 51, Issue:10

    Topics: Adult; Blood Pressure; Body Mass Index; Cross-Sectional Studies; Female; Heart Rate; Humans; Male; Nicotine; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Smoking Cessation; Stress, Psychological; Substance Withdrawal Syndrome; Young Adult

2014
Effect of nicotine withdrawal on pain sensitivity in rats to mechanical stimulation and thermal stimulation.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:18

    Topics: Animals; Hot Temperature; Injections, Subcutaneous; Male; Nicotine; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Random Allocation; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tobacco Use Disorder

2014
Effects of nicotinic acetylcholine receptor agonists in assays of acute pain-stimulated and pain-depressed behaviors in rats.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 355, Issue:2

    Topics: Acute Disease; Analgesics; Animals; Azetidines; Behavior, Animal; Benzamides; Brain; Bridged Bicyclo Compounds; Conditioning, Operant; Electric Stimulation; Male; Nicotine; Nicotinic Agonists; Pain; Pyridines; Rats, Sprague-Dawley; Self Stimulation

2015
Peripheral nerve injury alters spinal nicotinic acetylcholine receptor pharmacology.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Male; Nicotine; Pain; Peripheral Nervous System Diseases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Spinal Nerves

2008
Nicotine and postoperative management of pain.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:3

    Topics: Administration, Cutaneous; Analgesics; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Humans; Mice; Nicotine; Pain; Postoperative Period; Pyridines; Receptors, Cholinergic; Receptors, Nicotinic; Smoking; Spinal Cord

2008
The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.
    Neuropharmacology, 2009, Volume: 56, Issue:1

    Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Carbamates; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Epilepsy; Evoked Potentials, Auditory; Exploratory Behavior; Hippocampus; Male; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Agonists; Pain; Pain Threshold; Quinuclidines; Rats; Receptors, Nicotinic; Sensory Gating; Social Behavior; Time Factors

2009
Reduction of allodynia by intrathecal transplantation of microencapsulated porcine chromaffin cells.
    Artificial organs, 2009, Volume: 33, Issue:3

    Topics: Animals; Behavior, Animal; Catecholamines; Cattle; Cell- and Tissue-Based Therapy; Cells, Cultured; Cerebrospinal Fluid; Chromaffin Cells; Male; Models, Animal; Nicotine; Pain; Polylysine; Rats; Rats, Sprague-Dawley; Swine

2009
Nicotinic acetylcholine receptors mediate the hypnotic and analgesic effects of emulsified inhalation anesthetics.
    Fundamental & clinical pharmacology, 2009, Volume: 23, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Emulsions; Enflurane; Female; Injections, Intraventricular; Injections, Spinal; Isoflurane; Male; Methyl Ethers; Mice; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pilot Projects; Receptors, Nicotinic; Sevoflurane

2009
Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice.
    The journal of pain, 2009, Volume: 10, Issue:8

    Topics: Acetylcholine; Adenosine; Animals; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Hot Temperature; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Neostigmine; Nicotine; Obesity; Pain; Pain Measurement; Pons; Time Factors

2009
Effects of intrathecal injection of nicotine on the analgesic effects of isoflurane in a model of inflammatory pain.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:2

    Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Isoflurane; Mice; Nicotine; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Receptors, Nicotinic; Spinal Cord

2009
Characterization of pharmacological and behavioral differences to nicotine in C57Bl/6 and DBA/2 mice.
    Neuropharmacology, 2009, Volume: 57, Issue:4

    Topics: Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Classical; Drug Tolerance; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Pain; Phenotype; Space Perception; Species Specificity; Substance Withdrawal Syndrome

2009
The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 94, Issue:3

    Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Drug Interactions; Male; Morphine; Motor Activity; Nicotine; Pain; Rats; Rats, Sprague-Dawley; Stereoisomerism

2010
The effect of smoking on pain-related evoked potentials.
    Brain research, 2010, Feb-08, Volume: 1313

    Topics: Adult; Analysis of Variance; Brain; Cotinine; Electroencephalography; Evoked Potentials; Heart Rate; Humans; Linear Models; Male; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Physical Stimulation; Smoking; Time Factors; Young Adult

2010
Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Brain; Dose-Response Relationship, Drug; Hypothermia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motor Activity; Nicotine; Nicotinic Agonists; Pain; Pain Threshold; Protein Binding; Receptors, Nicotinic; Spinal Cord; Synaptosomes

2010
Smoking and chronic pain: a real-but-puzzling relationship.
    Minnesota medicine, 2011, Volume: 94, Issue:3

    Topics: Chronic Disease; Humans; Nicotine; Pain; Pain Threshold; Risk Factors; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder

2011
Nicotine replacement therapy in critically ill patients: a prospective observational cohort study.
    Critical care medicine, 2011, Volume: 39, Issue:7

    Topics: Adult; Aged; Critical Illness; Female; Hospital Mortality; Humans; Intensive Care Units; Male; Middle Aged; Nicotine; Pain; Prospective Studies; Psychomotor Agitation; Severity of Illness Index; Substance Withdrawal Syndrome

2011
Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation.
    Life sciences, 2011, Dec-19, Volume: 89, Issue:25-26

    Topics: Analgesics, Opioid; Animals; Corticosterone; Disease Models, Animal; Drug Administration Schedule; Fluorometry; Hypothalamo-Hypophyseal System; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Nicotinic Agonists; Pain; Pituitary-Adrenal System; Receptor Cross-Talk

2011
A pervasive mechanism for analgesia: activation of GIRK2 channels.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Jan-07, Volume: 100, Issue:1

    Topics: Analgesia; Analgesics; Animals; Baclofen; Benzoxazines; Clonidine; Crosses, Genetic; Ethanol; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Mutagenesis; Naphthalenes; Nicotine; Oxotremorine; Pain; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Sex Characteristics

2003
Effect of chlorpromazine on antidiuretic response to noxious stimuli.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1958, Volume: 99, Issue:1

    Topics: Chlorpromazine; Diuresis; Histamine; Histamine Agents; Nicotine; Pain

1958
Pain and inflammation induced by nicotine, acetylcholine and structurally related compounds and their prevention by desensitizing agents.
    Acta physiologica Academiae Scientiarum Hungaricae, 1961, Volume: 19

    Topics: Acetylcholine; Humans; Inflammation; Nicotine; Ozone; Pain

1961
Nicotine differentially activates inhibitory and excitatory neurons in the dorsal spinal cord.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Biomarkers; Calbindins; Dendrites; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neural Inhibition; Nicotine; Nociceptors; Pain; Posterior Horn Cells; Protein Subunits; Receptors, Neurokinin-1; Receptors, Nicotinic; RNA, Messenger; S100 Calcium Binding Protein G; Synaptic Transmission

2004
Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat.
    Autonomic neuroscience : basic & clinical, 2004, Jun-30, Volume: 113, Issue:1-2

    Topics: Animals; Female; Ganglia, Spinal; Male; Neurons; Nicotine; Pain; Rats; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger

2004
Porcine chromaffin cells, culture, and transplant for antinociceptive effects in rodents and primates.
    Neurological research, 2004, Volume: 26, Issue:7

    Topics: Animals; Behavior, Animal; Catecholamines; Cell Transplantation; Cells, Cultured; Chromaffin Cells; Chromatography, High Pressure Liquid; Enkephalins; Haplorhini; In Vitro Techniques; Male; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Swine; Time Factors; Transplantation, Heterologous

2004
Nicotine as therapy.
    PLoS biology, 2004, Volume: 2, Issue:11

    Topics: Acetylcholine; Animals; Attention; Body Weight; Brain; Gene Expression Regulation; Humans; Models, Biological; Neurotransmitter Agents; Nicotiana; Nicotine; Oligonucleotide Array Sequence Analysis; Pain; Smoking; Substance-Related Disorders

2004
The dorsal raphe nucleus as a site of action of the antinociceptive and behavioral effects of the alpha4 nicotinic receptor agonist epibatidine.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Formaldehyde; Male; Microinjections; Motor Activity; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2005
Antinociceptive effect of nicotine in various pain models in the mouse.
    Archives of pharmacal research, 2005, Volume: 28, Issue:2

    Topics: Analgesics; Animals; Behavior, Animal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Pain; Pain Measurement

2005
Nicotinic receptor involvement in antinociception induced by exposure to cigarette smoke.
    Neuroscience letters, 2005, Dec-02, Volume: 389, Issue:2

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mecamylamine; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Opioid, mu; Smoking

2005
In vivo characterization of a novel inhibitor of CNS nicotinic receptors.
    European journal of pharmacology, 2005, Oct-03, Volume: 521, Issue:1-3

    Topics: Analgesics; Animals; Body Temperature; Central Nervous System; Discrimination, Psychological; Dose-Response Relationship, Drug; Heptanoic Acids; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Pain; Pain Measurement; Piperidines; Rats; Rats, Long-Evans; Receptors, Nicotinic; Time Factors

2005
Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.
    Journal of medicinal chemistry, 2005, Nov-17, Volume: 48, Issue:23

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Ligands; Male; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Norbornanes; Pain; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism

2005
Persistent exercise attenuates nicotine- but not clonidine-induced antinociception in female rats.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 85, Issue:4

    Topics: Analgesia; Analgesics; Animals; Clonidine; Drug Tolerance; Female; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Physical Conditioning, Animal; Rats; Rats, Long-Evans; Receptors, Nicotinic

2006
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Membrane; Male; Mecamylamine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Nicotine; Nicotinic Antagonists; Pain; Pyridines; Quinolizines; Reaction Time; Receptors, Nicotinic; Spinal Cord

2007
Influence of nicotinic receptor modulators on CB2 cannabinoid receptor agonist (JWH133)-induced antinociception in mice.
    Behavioural pharmacology, 2007, Volume: 18, Issue:7

    Topics: Animals; Cannabinoids; Dose-Response Relationship, Drug; Formaldehyde; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Threshold; Receptor, Cannabinoid, CB2; Receptors, Nicotinic

2007
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
    Brain research, 2008, Jan-16, Volume: 1189

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Down-Regulation; Dynorphins; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger

2008
Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents.
    Molecular pain, 2007, Dec-19, Volume: 3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Choline O-Acetyltransferase; Electric Stimulation; Ganglia, Spinal; Male; Neural Inhibition; Neurons, Afferent; Nicotine; Oligonucleotides, Antisense; Pain; Pain Measurement; Spinal Cord; Synaptic Transmission

2007
Nicotine dependence criteria and nicotine withdrawal symptoms in relation to pain among an adult general population sample.
    European journal of pain (London, England), 2009, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Alcoholism; Data Interpretation, Statistical; Female; Germany; Humans; Logistic Models; Male; Middle Aged; Nicotine; Nicotinic Agonists; Odds Ratio; Pain; Substance Withdrawal Syndrome; Tobacco Use Disorder; Young Adult

2009
The effect of formalin pretreatment on nicotine-induced antinociceptive effect: the role of mu-opioid receptor in the hippocampus.
    Neuroscience, 2008, Jun-23, Volume: 154, Issue:2

    Topics: Acetic Acid; Analgesics; Animals; Benzoxazines; Blotting, Western; Brain; Coloring Agents; Drug Tolerance; Formaldehyde; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Oxazines; Pain; Pain Measurement; Receptors, Nicotinic; Receptors, Opioid, mu

2008
Nicotinic nociceptors on perivascular sensory nerve endings.
    Pain, 1982, Volume: 12, Issue:3

    Topics: Acetylcholine; Analgesics; Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Morphine; Nicotine; Nociceptors; Pain; Pilocarpine; Rabbits; Receptors, Cholinergic; Receptors, Nicotinic; Sensory Receptor Cells; Sensory Thresholds

1982
Nicotine ingestion reduces elevated blood pressures in rats and squirrel monkeys.
    Life sciences, 1981, Feb-16, Volume: 28, Issue:7

    Topics: Anger; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Male; Nicotine; Pain; Physical Stimulation; Rats; Saimiri

1981
The role of skin nociceptive afferent nerves in blister healing.
    Clinical and experimental neurology, 1993, Volume: 30

    Topics: Animals; Axons; Blister; Evoked Potentials; Neurons, Afferent; Neuropeptides; Nicotine; Nociceptors; Pain; Rats; Reflex; Skin; Wound Healing

1993
Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord.
    The Clinical investigator, 1993, Volume: 72, Issue:1

    Topics: Afferent Pathways; Analgesics; Animals; Atropine; Blood Pressure; Electric Stimulation; Female; Injections, Intravenous; Injections, Spinal; Male; Mecamylamine; Nerve Fibers; Nicotine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Sural Nerve; Thalamic Nuclei

1993
Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice.
    European journal of pharmacology, 1996, Apr-04, Volume: 300, Issue:1-2

    Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Stereoisomerism

1996
Nicotine enhances morphine- and beta-endorphin-induced antinociception at the supraspinal level in the mouse.
    Neuropeptides, 1996, Volume: 30, Issue:5

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Nociceptors; Pain; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa

1996
Inherited, selective hyporesponsiveness to the analgesic action of nicotine in mice.
    Neuroreport, 1996, Dec-20, Volume: 8, Issue:1

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Genotype; Hot Temperature; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Nicotine; Pain; Pain Measurement; Reaction Time; Receptors, Nicotinic

1996
Rectal response of cardiac origin in the cat: involvement of nitric oxide and acetylcholine.
    European journal of pharmacology, 1997, May-01, Volume: 325, Issue:2-3

    Topics: Acetylcholine; Afferent Pathways; Animals; Arginine; Atropine; Blood Pressure; Cats; Coronary Vessels; Female; Ganglionic Blockers; Heart; Hexamethonium; Male; Muscle Contraction; Muscle Relaxation; Myocardial Ischemia; Neurotransmitter Agents; Nicotine; Nitric Oxide; Nitroarginine; Pain; Phentolamine; Propranolol; Rectum

1997
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission

1997
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
    Science (New York, N.Y.), 1998, Jan-02, Volume: 279, Issue:5347

    Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Ligands; Mecamylamine; Morphine; Nerve Fibers; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Receptors, Nicotinic; Spinal Cord; Substance Withdrawal Syndrome; Synaptic Transmission

1998
Sex differences in cocaine- and nicotine-induced antinociception in the rat.
    Brain research, 1998, Oct-26, Volume: 809, Issue:1

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Female; Hot Temperature; Male; Nicotine; Nicotinic Agonists; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Sex Characteristics

1998
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists.
    Neuropharmacology, 1998, Volume: 37, Issue:12

    Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; Hindlimb; Hot Temperature; Injections, Spinal; Lobeline; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Pain; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine; Vocalization, Animal

1998
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits.
    Nature, 1999, Apr-29, Volume: 398, Issue:6730

    Topics: Analgesia; Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Neurons; Nicotine; Nicotinic Agonists; Pain; Pyridines; Raphe Nuclei; Receptors, Nicotinic; Spinal Cord; Thalamus

1999
Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3

    Topics: Animals; Body Temperature; Bupropion; Cocaine; Discrimination, Psychological; Female; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Molecular Structure; Motor Activity; Nicotine; Oocytes; Pain; Piperazines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recombinant Proteins; Seizures; Structure-Activity Relationship; Tropanes; Xenopus laevis

1999
Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine.
    Journal of neurophysiology, 1999, Volume: 82, Issue:6

    Topics: Action Potentials; Animals; Azetidines; Histamine; Histamine H1 Antagonists; Hot Temperature; Male; Mecamylamine; Microinjections; Narcotic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Stimulation, Chemical; Tachyphylaxis

1999
The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain.
    European journal of pharmacology, 2000, Mar-30, Volume: 393, Issue:1-3

    Topics: Analgesics; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Humans; Models, Molecular; Neurons; Nicotine; Nicotinic Agonists; Pain; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2000
Role of neuronal nicotinic-acetylcholine receptors in the activation of neurons in trigeminal subnucleus caudalis by nicotine delivered to the oral mucosa.
    Experimental brain research, 2000, Volume: 132, Issue:3

    Topics: Administration, Oral; Animals; Atropine; Male; Mecamylamine; Mouth Mucosa; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tachyphylaxis; Tongue; Trigeminal Caudal Nucleus

2000
Cross-desensitization of capsaicin-evoked oral irritation by high but not low concentrations of nicotine in human subjects.
    Neuroscience letters, 2000, Aug-25, Volume: 290, Issue:2

    Topics: Adult; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Nicotine; Nociceptors; Pain; Tongue

2000
The involvement of spinal Ca(2+)/calmodulin-protein kinase II in nicotine-induced antinociception in mice.
    European journal of pharmacology, 2000, Sep-15, Volume: 404, Issue:1-2

    Topics: Analgesics; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Interactions; Enzyme Inhibitors; Male; Mice; Nicotine; Nimodipine; Pain; Pain Measurement; Spinal Cord; Synaptosomes

2000
The analgesic potential of intraventricular polymer-encapsulated adrenal chromaffin cells in a rodent model of chronic neuropathic pain.
    Experimental and clinical psychopharmacology, 2000, Volume: 8, Issue:4

    Topics: Adrenal Glands; Analgesics; Animals; Cattle; Cell Transplantation; Chromaffin Cells; Chronic Disease; Disease Models, Animal; Ganglionic Stimulants; Hand Strength; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Nicotine; Pain; Pain Management; Polymers; Rats; Rats, Sprague-Dawley; Touch

2000
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
    Nature neuroscience, 2001, Volume: 4, Issue:4

    Topics: Acetic Acid; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Fixatives; Formaldehyde; Ganglionic Stimulants; Inflammation; Magnesium Sulfate; Mice; Mice, Transgenic; Morphine; Naloxone; Narcotic Antagonists; Nicotine; Opioid-Related Disorders; Pain; Substance Withdrawal Syndrome

2001
Analgesia induced by chronic nicotine infusion in rats: differences by gender and pain test.
    Psychopharmacology, 2001, Volume: 157, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Body Weight; Female; Male; Nicotine; Pain; Rats; Rats, Sprague-Dawley; Sex Factors

2001
Analgesic and toxic effects of neonicotinoid insecticides in mice.
    Toxicology and applied pharmacology, 2001, Nov-15, Volume: 177, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Fibroblasts; Imidazoles; Insecticides; Mecamylamine; Mice; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Thiazines; Time Factors

2001
Effects of nicotine, mecamylamine, and hexamethonium on shock-induced fighting, pain reactivity, and locomotor behaviour in rats.
    Psychopharmacology, 1979, Volume: 66, Issue:1

    Topics: Aggression; Animals; Electroshock; Hexamethonium Compounds; Humans; Male; Mecamylamine; Motor Activity; Nicotine; Pain; Rats

1979
Chemosensitive spinal afferents: thresholds of specific and nociceptive reflexes as compared with thresholds of excitation for receptors and axons.
    Progress in brain research, 1976, Volume: 43

    Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Carbachol; Cats; Chemoreceptor Cells; Histamine; Humans; Intestine, Small; Methacholine Compounds; Neurons, Afferent; Nicotine; Pain; Pilocarpine; Potassium; Reflex; Serotonin; Spinal Cord; Spinal Nerve Roots

1976
Nicotine enhances angina pectoris-like chest pain and atrioventricular blockade provoked by intravenous bolus of adenosine in healthy volunteers.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:6

    Topics: Adenosine; Adult; Angina Pectoris; Drug Synergism; Electrocardiography; Female; Heart Block; Heart Rate; Humans; Male; Middle Aged; Nicotine; Pain

1990
Effect of pCPA on nicotine-induced analgesia.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:2

    Topics: Analgesia; Animals; Drug Interactions; Fenclonine; Male; Mecamylamine; Naloxone; Nicotine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds

1990
Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats.
    Journal of neural transmission. General section, 1990, Volume: 80, Issue:3

    Topics: Analgesia; Animals; Injections, Spinal; Male; Mecamylamine; Nicotine; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stereoisomerism; Yohimbine

1990
Inhibition by neosurugatoxin of nicotine-induced antinociception.
    Brain research, 1986, Jun-11, Volume: 375, Issue:2

    Topics: Animals; Central Nervous System; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Mice; Mollusk Venoms; Nicotine; Pain; Pempidine; Receptors, Nicotinic

1986
Alpha-2 receptor blockade increases responsiveness of locus coeruleus neurons to excitatory stimulation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Idazoxan; Injections, Intravenous; Locus Coeruleus; Male; Neurons; Nicotine; Pain; Physical Stimulation; Rats; Rats, Inbred Strains; Yohimbine

1987
Analgesia induced by isolated bovine chromaffin cells implanted in rat spinal cord.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:19

    Topics: Analgesia; Animals; Chromaffin System; Naloxone; Nicotine; Pain; Rats; Spinal Cord; Subarachnoid Space

1986
Morphological and functional correlates of chromaffin cell transplants in CNS pain modulatory regions.
    Annals of the New York Academy of Sciences, 1987, Volume: 495

    Topics: Adrenal Medulla; Analgesia; Animals; Cattle; Chromaffin Granules; Female; Male; Microscopy, Electron; Nicotine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Transplantation, Heterologous

1987
Alterations in nociception following adrenal medullary transplants into the rat periaqueductal gray.
    Experimental brain research, 1987, Volume: 67, Issue:2

    Topics: Adrenal Medulla; Adrenergic Fibers; Animals; Endorphins; Female; Male; Naloxone; Nicotine; Pain; Periaqueductal Gray; Phentolamine; Rats; Rats, Inbred Strains

1987
The spinal cord as a major site for the antinociceptive action of nicotine in the rat.
    Neuropharmacology, 1986, Volume: 25, Issue:9

    Topics: Analgesia; Animals; Carotid Arteries; Injections, Intra-Arterial; Injections, Intraventricular; Injections, Subcutaneous; Male; Nicotine; Nociceptors; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Subarachnoid Space; Vertebral Artery

1986
Adrenal medullary tissue transplants in the rat spinal cord reduce pain sensitivity.
    Brain research, 1986, Oct-01, Volume: 384, Issue:1

    Topics: Adrenal Medulla; Analgesia; Animals; Chromaffin Granules; Endorphins; Female; Hot Temperature; Microscopy, Electron; Naloxone; Nicotine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Subarachnoid Space; Time Factors

1986
Synthesis and pharmacological action of some N-alkyl morpholines and their salts.
    The Journal of pharmacy and pharmacology, 1968, Volume: 20

    Topics: Acetylcholine; Animals; Female; Magnetic Resonance Spectroscopy; Mice; Morpholines; Nicotine; Pain; Pentylenetetrazole; Seizures; Spectrophotometry; Ultraviolet Rays

1968
[The "paw flick" test, using a modified burning ray method for analgesimedric studies on rats under special circumstances].
    Acta biologica et medica Germanica, 1974, Volume: 33, Issue:3

    Topics: Animals; Arecoline; Avoidance Learning; Escape Reaction; Hindlimb; Nicotine; Pain; Radiation Injuries, Experimental; Rats; Reaction Time; Reactive Inhibition; Tail

1974
Green-tobacco sickness. An illness of tobacco harvesters.
    JAMA, 1974, Sep-30, Volume: 229, Issue:14

    Topics: Abdomen; Adolescent; Agricultural Workers' Diseases; Environmental Exposure; Female; Headache; Humans; Humidity; Male; Nausea; Nicotiana; Nicotine; North Carolina; Occupations; Pain; Pallor; Plants, Toxic; Salivation; Seasons; Smoking; Sweating; Time Factors; Vomiting

1974
Smoking, physiological arousal, and emotional response.
    Journal of personality and social psychology, 1973, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Arousal; Differential Threshold; Electroshock; Emotions; Humans; Male; Nicotiana; Nicotine; Pain; Plants, Toxic; Pulse; Smoking

1973
Antin ociceptive activity of nicotine.
    Acta physiologica Academiae Scientiarum Hungaricae, 1973, Volume: 44, Issue:1

    Topics: Acetates; Analgesia; Animals; Dimethylphenylpiperazinium Iodide; Drug Tolerance; Injections, Intraperitoneal; Mecamylamine; Methods; Mice; Nicotine; Oxotremorine; Pain; Physostigmine; Rats; Reaction Time; Seizures; Tremorine

1973
[Correlation between the chemical structure and algogenic activity of some vasoactive substances].
    Bollettino della Societa italiana di biologia sperimentale, 1968, Dec-15, Volume: 44, Issue:23

    Topics: Amphetamine; Animals; Nicotine; Pain; Peptides; Rats; Vasoconstrictor Agents; Vasodilator Agents

1968
The action of nicotine on the blood vessels of the hand and forearm in man.
    British journal of pharmacology and chemotherapy, 1966, Volume: 26, Issue:3

    Topics: Anesthesia, Conduction; Arm; Blood Flow Velocity; Blood Vessels; Denervation; Hand; Hexamethonium Compounds; Humans; Injections, Intra-Arterial; Male; Nicotine; Pain; Phenoxybenzamine; Reflex; Scopolamine; Sympathectomy; Sympathetic Nervous System; Sympatholytics

1966