Page last updated: 2024-08-21

nicotinamide mononucleotide and Aging

nicotinamide mononucleotide has been researched along with Aging in 40 studies

*Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. [MeSH]

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.50)18.7374
1990's0 (0.00)18.2507
2000's1 (2.50)29.6817
2010's15 (37.50)24.3611
2020's21 (52.50)2.80

Authors

AuthorsStudies
Chai, H; Chen, Y; Cheng, Y; Liu, X; Wei, Z1
Okumura, K; Takeda, K1
Cheng, DY; Peng, F; Shen, Q; Xue, YP; Xue, YZ; Zhang, SJ; Zheng, YG1
Gong, A; Huang, P; Jiang, A; Qian, X; Ren, C; Tang, W; Wang, X; Zhou, Y; Zhou, Z1
Dilxat, T; Lin, J; Liu, X; Qiu, T; Shi, Q1
Bertoldo, MJ; Campbell, JM; Gilchrist, RB; Goldys, EM; Goss, DM; Habibalahi, A; Ledger, WL; Mahbub, SB; Wu, LE1
Lalam, SK; Soma, M1
Li, J; Lu, J; Nadeeshani, H; Ying, T; Zhang, B1
Kothari, D; Li, Y; Liang, J; Niu, K; Ru, M; Wang, R; Wang, W; Wu, X; Zhai, Z1
Braidy, N; Helman, T1
Craighead, DH; Freeberg, KA; Martens, CR; Seals, DR; Udovich, CC1
Gong, JS; Liu, Y; Marshall, G; Shi, JS; Su, C; Xu, ZH1
Kang, S; Rathmann, A; Sauve, AA; Wang, Q; Yang, Y; Zhang, N1
Chen, L; Chen, M; Hou, Y; Hu, M; Liu, R; Luan, J; Wang, P; Yu, Q1
Balasubramanian, P; Csipo, T; Csiszar, A; Farkas, E; Gautam, T; Giles, CB; Kiss, T; Lipecz, A; Nyúl-Tóth, Á; Szabo, C; Tarantini, S; Ungvari, Z; Wren, JD; Yabluchanskiy, A1
Badalzadeh, R; Farokhi-Sisakht, F; Hosseini, L; Khabbaz, A; Mahmoudi, J; Sadigh-Eteghad, S1
Braidy, N; Liu, Y1
Choi, JY; Kang, BE; Ryu, D; Stein, S1
Cui, Z; Gao, Q; Miao, Y; Rui, R; Xiong, B1
Chen, Y; Deng, H; Luo, C; Ma, Y; Wang, Q; Yi, M; Zhu, S1
Agorrody, G; Baker, DJ; Baur, JA; Chellappa, K; Childs, BG; Chini, CCS; Chini, EN; Clarke, S; Dang, K; De Cecco, M; de Oliveira, GC; Espindola-Netto, JM; Gomez, LS; Hogan, KA; Jankowski, C; Kanamori, KS; Kashyap, S; Kirkland, AL; Kirkland, JL; McReynolds, MR; Peclat, TR; Puranik, AS; Rabinowitz, JD; Sedivy, JM; Tarragó, MG; Tchkonia, T; Thompson, KL; van Deursen, JM; van Schooten, W; Vidal, P; Warner, GM; Witte, MA1
Khodorkovskiy, M; Kropotov, A; Kulikova, V; Migaud, ME; Nerinovski, K; Nikiforov, A; Solovjeva, L; Sudnitsyna, J; Svetlova, M; Yakimov, A; Ziegler, M1
Badalzadeh, R; Feyzizadeh, S; Hosseini, L; Høilund-Carlsen, PF; Jafari-Azad, A; Rajabi, M; Vafaee, MS1
Djouder, N; Garrido, A1
Alemifar, A; Bao, R; Ding, S; Han, X; Polo-Parada, L; Swerdlow, RH; Tarim, A; Wang, X; Wang, Y; Wilkins, HM; Zhang, N; Zhang, Q1
Baur, JA; Imai, SI; Yoshino, J1
Bartoli, M; Fuller, J; Jadeja, RN; Jones, MA; Joseph, E; Martin, PM; Powell, FL; Thounaojam, MC1
Badalzadeh, R; Hosseini, L; Mahmoudi, J; Vafaee, MS1
Li, J; Lin, D; Ning, G; Peng, L; Song, J; Wu, L; Xie, C; Yang, F; Zhang, Q; Zhen, L; Zheng, Y1
Balasubramanian, P; Bari, F; Csipo, T; Csiszar, A; Farkas, E; Kiss, T; Lipecz, A; Reglodi, D; Tarantini, S; Ungvari, Z; Valcarcel-Ares, MN; Yabluchanskiy, A; Zhang, XA1
Imai, S; Stein, LR1
de Picciotto, NE; Gano, LB; Imai, S; Johnson, LC; Martens, CR; Mills, KF; Seals, DR; Sindler, AL1
Li, WL; Miao, CY; Wang, SN; Xu, TY1
Kawamura, T; Mori, N; Shibata, K1
Imai, S1
Imai, S; Mills, KF; Yoon, MJ; Yoshino, J1
HABERMANN, V; HABERMANNOVA, S2
Imai, S; Mills, KF; Ramsey, KM; Satoh, A1
Foster, AC; Schwarcz, R; Zinkand, WC1

Reviews

14 review(s) available for nicotinamide mononucleotide and Aging

ArticleYear
Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?
    Current opinion in pharmacology, 2021, Volume: 60

    Topics: Aging; Dietary Supplements; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide

2021
Biological synthesis of nicotinamide mononucleotide.
    Biotechnology letters, 2021, Volume: 43, Issue:12

    Topics: Adenosine; Adenosine Triphosphate; Aging; Cytokines; Humans; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Nucleotides; Ribose; Xylose

2021
The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.
    Molecular biology reports, 2022, Volume: 49, Issue:10

    Topics: Aging; Animals; Chronic Disease; Humans; Longevity; Mice; NAD; Nicotinamide Mononucleotide

2022
Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns.
    Journal of advanced research, 2022, Volume: 37

    Topics: Aged; Aging; Cognitive Dysfunction; Humans; Longevity; NAD; Nicotinamide Mononucleotide

2022
Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders.
    Drugs & aging, 2023, Volume: 40, Issue:1

    Topics: Aging; Dietary Supplements; Humans; NAD; Neurodegenerative Diseases; Niacinamide; Nicotinamide Mononucleotide

2023
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2023, Dec-01, Volume: 78, Issue:12

    Topics: Aged; Aging; Dietary Supplements; Humans; NAD; Nicotinamide Mononucleotide; Obesity

2023
Technology and functional insights into the nicotinamide mononucleotide for human health.
    Applied microbiology and biotechnology, 2023, Volume: 107, Issue:15

    Topics: Aging; Humans; NAD; Nicotinamide Mononucleotide; Technology

2023
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.
    Experimental gerontology, 2020, Volume: 132

    Topics: Aging; Animals; Humans; Inflammation; Mice; NAD; Neurodegenerative Diseases; Niacinamide; Nicotinamide Mononucleotide; Oxidative Stress; Pyridinium Compounds; Rats; Risk Assessment

2020
Implications of NAD
    European journal of clinical investigation, 2020, Volume: 50, Issue:10

    Topics: ADP-ribosyl Cyclase; Aging; Animals; Biosynthetic Pathways; Carboxy-Lyases; Clinical Trials as Topic; Enzyme Inhibitors; Gastrointestinal Microbiome; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Probiotics; Pyridinium Compounds; Sirtuins; Translational Research, Biomedical

2020
NAD
    Trends in cancer, 2017, Volume: 3, Issue:8

    Topics: Aging; Humans; Incidence; Life Expectancy; Longevity; NAD; Neoplasms; Niacinamide; Nicotinamide Mononucleotide; Vitamin B Complex

2017
NAD
    Cell metabolism, 2018, 03-06, Volume: 27, Issue:3

    Topics: Aging; Animals; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds

2018
Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions.
    Biogerontology, 2019, Volume: 20, Issue:4

    Topics: Aging; Drug Discovery; Humans; Ischemia; Mitochondria; NAD; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds

2019
Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis.
    CNS neuroscience & therapeutics, 2016, Volume: 22, Issue:6

    Topics: Aging; Animals; Humans; NAD; Nervous System Diseases; Neurogenesis; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase

2016
A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.
    Pharmacological research, 2010, Volume: 62, Issue:1

    Topics: Aging; Animals; Drug Design; Enzyme Activation; Flavonoids; Humans; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Phenols; Polyphenols; Sirtuins; Small Molecule Libraries

2010

Other Studies

26 other study(ies) available for nicotinamide mononucleotide and Aging

ArticleYear
Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice.
    Biomedical research (Tokyo, Japan), 2021, Volume: 42, Issue:5

    Topics: Aging; Animals; Killer Cells, Natural; Mice; Mice, Inbred BALB C; NAD; Nicotinamide Mononucleotide

2021
Long-term treatment of Nicotinamide mononucleotide improved age-related diminished ovary reserve through enhancing the mitophagy level of granulosa cells in mice.
    The Journal of nutritional biochemistry, 2022, Volume: 101

    Topics: Aging; Animals; Autophagy; Cathepsin D; Cyclin-Dependent Kinase Inhibitor p16; Endopeptidase Clp; Estrous Cycle; Female; Granulosa Cells; Mice; Mice, Inbred ICR; Mitophagy; Nicotinamide Mononucleotide; Organelle Biogenesis; Ovarian Follicle; Ovarian Reserve; Ovary

2022
The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling.
    Gene, 2022, May-15, Volume: 822

    Topics: Aging; Animals; Cognitive Dysfunction; Drug Therapy, Combination; Galactose; Gene Expression Regulation; Kelch-Like ECH-Associated Protein 1; Lycopene; Male; Morris Water Maze Test; NF-E2-Related Factor 2; Nicotinamide Mononucleotide; Oxidative Stress; PC12 Cells; Rats; Signal Transduction; Spatial Learning; Treatment Outcome

2022
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes.
    Biogerontology, 2022, Volume: 23, Issue:2

    Topics: Aging; Animals; Female; Fertility; Mice; NAD; Nicotinamide Mononucleotide; Oocytes

2022
Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells.
    Food & function, 2022, Jul-18, Volume: 13, Issue:14

    Topics: Aging; Animals; Antioxidants; Cellular Senescence; Claudin-1; Dietary Supplements; Galactose; Mice; NAD; Nicotinamide Mononucleotide; Occludin; RNA, Messenger; Sirtuins

2022
Triple-Isotope Tracing for Pathway Discernment of NMN-Induced NAD
    International journal of molecular sciences, 2023, Jul-05, Volume: 24, Issue:13

    Topics: Aging; Animals; Biological Transport; Humans; Mice; NAD; Nicotinamide Mononucleotide

2023
Fingerstick blood assay maps real-world NAD
    Aging cell, 2023, Volume: 22, Issue:10

    Topics: Aging; Female; Humans; Male; NAD; Nicotinamide Mononucleotide; Pyridinium Compounds

2023
Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.
    GeroScience, 2019, Volume: 41, Issue:4

    Topics: Aging; Animals; Aorta; Atherosclerosis; Dietary Supplements; Endothelium, Vascular; Epigenesis, Genetic; Gene Expression Profiling; Mice, Inbred C57BL; MicroRNAs; Nicotinamide Mononucleotide; Rejuvenation

2019
Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus.
    Neuroscience, 2019, 12-15, Volume: 423

    Topics: Adenosine Triphosphate; Aging; Animals; Apoptosis; Cognitive Dysfunction; Drug Synergism; Hippocampus; Male; Maze Learning; Melatonin; Membrane Potential, Mitochondrial; Mitochondria; Nicotinamide Mononucleotide; Prefrontal Cortex; Rats; Reactive Oxygen Species; Recognition, Psychology

2019
Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes.
    Cell reports, 2020, 08-04, Volume: 32, Issue:5

    Topics: Aging; Animals; Apoptosis; Cellular Senescence; Chromosomes, Mammalian; Cytoplasmic Granules; Dietary Supplements; DNA Damage; Embryonic Development; Female; Fertilization; Kinetochores; Male; Meiosis; Metalloproteases; Mice, Inbred ICR; Microtubules; Mitochondria; NAD; Nicotinamide Mononucleotide; Oocytes; Reactive Oxygen Species; Spermatozoa; Spindle Apparatus; Transcriptome

2020
Comparative proteomic analysis identifies biomarkers for renal aging.
    Aging, 2020, 11-06, Volume: 12, Issue:21

    Topics: Age Factors; Aging; Animals; Biomarkers; Chromatography, Reverse-Phase; Databases, Protein; Kidney; Mice; Mice, Inbred C57BL; Nicotinamide Mononucleotide; Peroxisomes; Proteome; Proteomics; Proteostasis; Tandem Mass Spectrometry

2020
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD
    Nature metabolism, 2020, Volume: 2, Issue:11

    Topics: Adipocytes, White; Adipose Tissue, White; ADP-ribosyl Cyclase 1; Aging; Animals; Bone Marrow Transplantation; Cellular Senescence; HEK293 Cells; Humans; Inflammation; Liver; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NAD; Nicotinamide Mononucleotide; Phenotype

2020
Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells.
    International journal of molecular sciences, 2021, Jan-30, Volume: 22, Issue:3

    Topics: Aging; Cytosol; Equilibrative Nucleoside Transport Proteins; HEK293 Cells; Humans; Magnetic Resonance Spectroscopy; Membrane Transport Proteins; Metabolomics; NAD; Niacinamide; Nicotinamide Mononucleotide; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Recombinant Proteins; Ribonucleosides

2021
Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats.
    Molecular biology reports, 2021, Volume: 48, Issue:4

    Topics: Aging; Animals; Apoptosis; Drug Combinations; Forkhead Box Protein O1; Heart; Male; Melatonin; Myocardial Reperfusion Injury; Nerve Tissue Proteins; Nicotinamide Mononucleotide; Rats; Rats, Wistar; Signal Transduction; Sirtuin 3

2021
Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death.
    Cell reports, 2017, Aug-29, Volume: 20, Issue:9

    Topics: Aging; Amyotrophic Lateral Sclerosis; Animals; Behavior, Animal; Cell Death; Gene Deletion; Gliosis; Homeostasis; Humans; Mice, Knockout; Mitochondria; Motor Activity; Motor Cortex; Muscular Atrophy; Nerve Degeneration; Neuromuscular Junction; Neurons; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Synaptic Transmission

2017
Loss of NAMPT in aging retinal pigment epithelium reduces NAD
    Aging, 2018, Jun-12, Volume: 10, Issue:6

    Topics: Acrylamides; Aging; Animals; Cells, Cultured; Cytokines; Epithelial Cells; Gene Expression Regulation; Humans; Male; Mice; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines; Retinal Pigment Epithelium; Reverse Transcriptase Polymerase Chain Reaction

2018
Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow.
    Cell death & disease, 2019, 04-18, Volume: 10, Issue:5

    Topics: Adipogenesis; Aging; Animals; Bone and Bones; Bone Marrow Cells; Cell Differentiation; Cell Self Renewal; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinamide Mononucleotide; Osteogenesis; Sirtuin 1; Up-Regulation; Whole-Body Irradiation

2019
Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.
    GeroScience, 2019, Volume: 41, Issue:5

    Topics: Aging; Animals; Brain; Cell Movement; Cell Proliferation; Cognitive Dysfunction; Endothelial Cells; Hydrogen Peroxide; Microvessels; Neovascularization, Physiologic; Nicotinamide Mononucleotide; Oxidative Stress; Rats, Inbred BN; Rats, Inbred F344

2019
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging.
    The EMBO journal, 2014, Jun-17, Volume: 33, Issue:12

    Topics: Adult Stem Cells; Aging; Animals; Bromodeoxyuridine; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Crosses, Genetic; Cuprizone; Cytokines; Fluorescent Antibody Technique; Mice; Mice, Transgenic; Neural Stem Cells; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase

2014
Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice.
    Aging cell, 2016, Volume: 15, Issue:3

    Topics: Aging; Animals; Aorta; Dietary Supplements; Elasticity; Endothelium, Vascular; Male; Mice, Inbred C57BL; Nicotinamide Mononucleotide; Nitric Oxide; Oxidative Stress; Sirtuin 1; Superoxide Dismutase; Vascular Stiffness; Vasodilation

2016
β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats.
    Journal of nutritional science and vitaminology, 2016, Volume: 62, Issue:4

    Topics: Aging; Animals; Injections, Intraperitoneal; Longevity; Male; NAD; Niacinamide; Nicotinamide Mononucleotide; Rats; Rats, Wistar

2016
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
    Cell metabolism, 2011, Oct-05, Volume: 14, Issue:4

    Topics: Aging; Animals; Circadian Rhythm; Cytokines; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Glucose; Hypoglycemic Agents; Insulin; Lipid Metabolism; Mice; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Sirtuin 1

2011
Age difference in nicotinamide mononucleotide synthesis by human erythrocytes.
    Nature, 1960, Apr-30, Volume: 186

    Topics: Aging; Erythrocytes; Humans; Niacin; Nicotinamide Mononucleotide; Nicotinic Acids

1960
Age difference in nicotinamide mononucleotide synthesis by human erythrocytes.
    Folia haematologica (Leipzig, Germany : 1928), 1962, Volume: 78

    Topics: Aging; Erythrocytes; Nicotinamide Mononucleotide; Nucleosides; Nucleotides

1962
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
    Aging cell, 2008, Volume: 7, Issue:1

    Topics: Aging; Animals; Female; Glucose; Glucose Tolerance Test; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channels; Islets of Langerhans; Male; Mice; Mice, Transgenic; Mitochondrial Proteins; NAD; Nicotinamide Mononucleotide; Sirtuin 1; Sirtuins; Uncoupling Protein 2

2008
Quinolinic acid phosphoribosyltransferase in rat brain.
    Journal of neurochemistry, 1985, Volume: 44, Issue:2

    Topics: Aging; Animals; Brain; Kinetics; Liver; Nicotinamide Mononucleotide; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Phthalic Acids; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Retina; Substrate Specificity; Tissue Distribution

1985