nicotinamide-beta-riboside and Sepsis

nicotinamide-beta-riboside has been researched along with Sepsis* in 2 studies

Other Studies

2 other study(ies) available for nicotinamide-beta-riboside and Sepsis

Article	Year
SUPPLEMENTATION WITH NICOTINAMIDE RIBOSIDE ATTENUATES T CELL EXHAUSTION AND IMPROVES SURVIVAL IN SEPSIS. Shock (Augusta, Ga.), 2023, 08-01, Volume: 60, Issue:2 T cell exhaustion is the main cause of sepsis-induced immunosuppression and is associated with the poor prognosis. Nicotinamide adenine dinucleotide (NAD + ) is well known for its anti-aging effect, but its role in sepsis-induced T cell exhaustion remains to be elucidated. In the present study, using a classic septic animal model, we found that the levels of NAD + and its downstream molecule, which is sirtuins 1 (SIRT1), in T cells in sepsis were decreased. Supplementation with nicotinamide ribose (NR), the precursor of NAD + , right after cecal ligation and puncture significantly increased the levels of NAD + and SIRT1. Supplementation with NR alleviated the depletion of mononuclear cells and T lymphocytes in spleen in sepsis and increased the levels of CD3 + CD4 + and CD3 + CD8 + T cells. Interestingly, both Th1 and Th2 cells were expanded after NR treatment, but the balance of Th1/Th2 was partly restored. Nicotinamide ribose also inhibited the regulatory T cells expansion and programmed cell death 1 expression in CD4 + T cells in sepsis. In addition, the bacteria load, organ damage (lung, heart, liver, and kidney), and the mortality of septic mice were reduced after NR supplementation. In summary, these results demonstrate the beneficial effect of NR on sepsis and T cell exhaustion, which is associated with NAD + /SIRT1 pathway. Topics: Animals; Dietary Supplements; Mice; NAD; Sepsis; Sirtuin 1; T-Cell Exhaustion	2023
Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis. Free radical biology & medicine, 2018, 08-01, Volume: 123 Sepsis-caused multiple organ failure remains the major cause of morbidity and mortality in intensive care units. Nicotinamide riboside (NR) is a precursor of nicotinamide adenine dinucleotide (NAD. Mouse sepsis models were induced by injection of lipopolysaccharides (LPS) or feces-injection-in-peritoneum. NR was given before sepsis onset. Cultured macrophages and endothelial cells were incubated with various agents.. Administration of NR elevated the NAD Topics: Animals; Apoptosis; Disease Models, Animal; HMGB1 Protein; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Multiple Organ Failure; Niacinamide; Oxidative Stress; Pyridinium Compounds; Sepsis	2018

Article

Year

SUPPLEMENTATION WITH NICOTINAMIDE RIBOSIDE ATTENUATES T CELL EXHAUSTION AND IMPROVES SURVIVAL IN SEPSIS.

Shock (Augusta, Ga.), 2023, 08-01, Volume: 60, Issue:2

T cell exhaustion is the main cause of sepsis-induced immunosuppression and is associated with the poor prognosis. Nicotinamide adenine dinucleotide (NAD + ) is well known for its anti-aging effect, but its role in sepsis-induced T cell exhaustion remains to be elucidated. In the present study, using a classic septic animal model, we found that the levels of NAD + and its downstream molecule, which is sirtuins 1 (SIRT1), in T cells in sepsis were decreased. Supplementation with nicotinamide ribose (NR), the precursor of NAD + , right after cecal ligation and puncture significantly increased the levels of NAD + and SIRT1. Supplementation with NR alleviated the depletion of mononuclear cells and T lymphocytes in spleen in sepsis and increased the levels of CD3 + CD4 + and CD3 + CD8 + T cells. Interestingly, both Th1 and Th2 cells were expanded after NR treatment, but the balance of Th1/Th2 was partly restored. Nicotinamide ribose also inhibited the regulatory T cells expansion and programmed cell death 1 expression in CD4 + T cells in sepsis. In addition, the bacteria load, organ damage (lung, heart, liver, and kidney), and the mortality of septic mice were reduced after NR supplementation. In summary, these results demonstrate the beneficial effect of NR on sepsis and T cell exhaustion, which is associated with NAD + /SIRT1 pathway.

Topics: Animals; Dietary Supplements; Mice; NAD; Sepsis; Sirtuin 1; T-Cell Exhaustion

2023

Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis.

Free radical biology & medicine, 2018, 08-01, Volume: 123

Sepsis-caused multiple organ failure remains the major cause of morbidity and mortality in intensive care units. Nicotinamide riboside (NR) is a precursor of nicotinamide adenine dinucleotide (NAD. Mouse sepsis models were induced by injection of lipopolysaccharides (LPS) or feces-injection-in-peritoneum. NR was given before sepsis onset. Cultured macrophages and endothelial cells were incubated with various agents.. Administration of NR elevated the NAD

Topics: Animals; Apoptosis; Disease Models, Animal; HMGB1 Protein; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Multiple Organ Failure; Niacinamide; Oxidative Stress; Pyridinium Compounds; Sepsis

2018