Compounds > nicorandil
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nicorandil and Reperfusion Injury

nicorandil has been researched along with Reperfusion Injury in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.57)18.7374
1990's4 (14.29)18.2507
2000's7 (25.00)29.6817
2010's9 (32.14)24.3611
2020's7 (25.00)2.80

Authors

AuthorsStudies
Erlitz, L; Hardi, P; Ibitamuno, C; Jancsó, G; Kasza, B; Sétáló, G; Takács, I; Telek, V; Vecsernyés, M1
Abe, K; Enzan, K; Horiguchi, T; Kimura, T; Masaki, Y; Nishikawa, T1
Abdel-Gaber, SA; Abdel-Hafez, SMN; Abdelzaher, WY; Atta, M1
Bigdeli, MR; Namavar, MR; Owjfard, M; Safari, A1
Aftab, M; Cheng, L; Cleveland, JC; Fullerton, DA; Ghincea, CV; Ikeno, Y; Meng, X; Reece, TB; Roda, GF; Weyant, MJ2
Gu, X; Ma, Z; Wu, M1
Ashrafpour, H; Cahoon, NJ; Forrest, CR; Hofer, SOP; Huang, N; Lipa, JE; Naparus, A; Pang, CY1
Tian, ZL; Yao, L; Zhang, AQ; Zhang, YJ; Zhao, XX1
Ding, J; Dong, W; Wang, X; Wu, H; Yang, J; Ye, M1
Fan, C; Feng, Y; Hu, L; Mo, X; Wen, Z; Yang, L; Yin, KJ; Yu, D; Zhang, W1
Chen, JB; Hou, ZQ; Hu, HR; Ji, XF; Liang, LN; Shang, DY; Zhong, X; Zhou, Y; Zhu, FF1
Hirai, K; Kobayashi, K; Matsumoto, K; Odawara, H; Oshima, K; Sato, H; Suto, Y; Takeyoshi, I; Yamazaki, H1
Dimitriadis, F; Hayashi, A; Kinoshita, Y; Ohmasa, F; Saito, M; Satoh, K; Shimizu, S; Shomori, K1
Arakawa, K; Matsumoto, K; Oshima, K; Sato, H; Suto, Y; Takeyoshi, I; Yamazaki, H1
Li, ST; Wang, ZP; Xia, YF; Yan, T; Zhou, YC1
Fukuda, S; Ikeda, N; Imai, N; Ishizuka, N; Kawakami, M; Kuroki, M; Matsuda, E; Saito, M; Schmid-Schönbein, GW; Ueba, H; Yasu, T1
Asakura, M; Asanuma, H; Jiyoong, K; Kitakaze, M; Minamino, T; Shintani, Y1
Endo, S; Inada, K; Kadosaki, M; Kawamura, T; Nara, N; Wei, J1
Carreira, R; Gonçalves, LM; Monteiro, P; Providência, LA1
Asakura, M; Asanuma, H; Fujii, K; Fukuzawa, S; Hamasaki, T; Hirayama, A; Ishihara, M; Kim, J; Kimura, K; Kitakaze, M; Kitamura, S; Minamino, T; Myoishi, M; Nagai, Y; Nakamura, N; Nanto, S; Ohara, T; Saito, Y; Seguchi, O; Shintani, Y; Tomoike, H; Watanabe, K1
Klein, HH; Lindert-Heimberg, S; Maisch, B; Nebendahl, K; Pich, S; Schade-Brittinger, C1
Aniya, Y; Naito, A; Sakanashi, M1
Cooper, JD; Fujino, S; Patterson, GA; Schmid, RA; Yamashita, M1
Chambers, DJ1
Das, B; Karanth, KS; Sarkar, C2
Ajioka, M; Fukushima, A; Hanaki, Y; Kondo, T; Ozawa, T; Sugiyama, S1

Reviews

2 review(s) available for nicorandil and Reperfusion Injury

ArticleYear
Mitochondrial Quality Control in Cerebral Ischemia-Reperfusion Injury.
    Molecular neurobiology, 2021, Volume: 58, Issue:10

    Topics: Animals; Antioxidants; Brain Ischemia; Humans; Ischemic Stroke; Mitochondria; Mitochondrial Dynamics; Mitophagy; Nicorandil; Reperfusion Injury; Vasodilator Agents

2021
Polarization and myocardial protection.
    Current opinion in cardiology, 1999, Volume: 14, Issue:6

    Topics: Animals; Calcium Channels; Cardiac Surgical Procedures; Cardioplegic Solutions; Female; Heart Arrest, Induced; Humans; Hyperkalemia; Male; Membrane Potentials; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channels; Prognosis; Rabbits; Reperfusion Injury; Sensitivity and Specificity; Survival Rate

1999

Trials

4 trial(s) available for nicorandil and Reperfusion Injury

ArticleYear
Cerebral protective effect of nicorandil premedication on patients undergoing liver transplantation.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2012, Volume: 11, Issue:2

    Topics: Administration, Oral; Brain Injuries; Humans; Intelligence Tests; KATP Channels; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Nerve Growth Factors; Nicorandil; Phosphopyruvate Hydratase; Reperfusion Injury; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Treatment Outcome

2012
Rationale and design of a large-scale trial using nicorandil as an adjunct to percutaneous coronary intervention for ST-segment elevation acute myocardial infarction: Japan-Working groups of acute myocardial infarction for the reduction of Necrotic Damage
    Circulation journal : official journal of the Japanese Circulation Society, 2004, Volume: 68, Issue:2

    Topics: Adult; Aged; Biomarkers; Cardiac Surgical Procedures; Clinical Protocols; Creatine Kinase; Data Collection; Electrocardiography; Humans; Middle Aged; Myocardial Infarction; Necrosis; Nicorandil; Potassium Channels; Reperfusion Injury; Research Design; Sample Size; Troponin T; Ventricular Function, Left

2004
Nicorandil attenuates NF-kappaB activation, adhesion molecule expression, and cytokine production in patients with coronary artery bypass surgery.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:2

    Topics: Antihypertensive Agents; Aorta; Brain; CD18 Antigens; Cell Adhesion; Coronary Artery Bypass; Creatine Kinase; Cytokines; Flow Cytometry; Granulocytes; Hemodynamics; Humans; Interleukin-6; Interleukin-8; Lipopolysaccharides; Monocytes; Muscles; Myocardium; NF-kappa B; Nicorandil; Potassium Channels; Reperfusion Injury; Time Factors; Troponin T

2005
Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials.
    Lancet (London, England), 2007, Oct-27, Volume: 370, Issue:9597

    Topics: Atrial Natriuretic Factor; Creatine Kinase; Female; Humans; Infusions, Intravenous; Japan; Male; Middle Aged; Myocardial Infarction; Nicorandil; Reperfusion Injury; Vasodilator Agents

2007

Other Studies

22 other study(ies) available for nicorandil and Reperfusion Injury

ArticleYear
Subnormothermic isolated organ perfusion with Nicorandil increased cold ischemic tolerance of liver in experimental model.
    Clinical hemorheology and microcirculation, 2022, Volume: 81, Issue:1

    Topics: Animals; Cold Temperature; Inflammation; Ischemia; Liver; Male; Microcirculation; Models, Theoretical; Nicorandil; Organ Preservation; Perfusion; Rats; Rats, Wistar; Reperfusion Injury

2022
Nicorandil, a K
    Lung, 2020, Volume: 198, Issue:2

    Topics: Animals; Capillary Permeability; Cyclic GMP; KATP Channels; Lung; Lung Injury; Male; Membrane Transport Modulators; Nicorandil; Perfusion; Pulmonary Circulation; Pulmonary Edema; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Soluble Guanylyl Cyclase; Vascular Resistance

2020
Ameliorative effect of nicorandil in ovarian ischemia-reperfusion-induced injury in rats: role of potassium channel.
    Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Disease Models, Animal; Female; KATP Channels; Nicorandil; Ovarian Diseases; Ovary; Oxidative Stress; Rats; Reperfusion Injury; Signal Transduction

2020
Effects of nicorandil on neurobehavioral function, BBB integrity, edema and stereological parameters of the brain in the sub-acute phase of stroke in a rat model.
    Journal of biosciences, 2020, Volume: 45

    Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Nicorandil; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke

2020
Optimizing Nicorandil for Spinal Cord Protection in a Murine Model of Complex Aortic Intervention.
    Seminars in thoracic and cardiovascular surgery, 2022,Spring, Volume: 34, Issue:1

    Topics: Animals; Disease Models, Animal; Humans; Ischemia; KATP Channels; Male; Mice; Mice, Inbred C57BL; Nicorandil; Reperfusion Injury; Spinal Cord Ischemia; Treatment Outcome

2022
Reactive Oxygen Species Mediate Nicorandil-induced Metabolic Tolerance to Spinal Cord Injury.
    The Annals of thoracic surgery, 2021, Volume: 112, Issue:1

    Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Nicorandil; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Spinal Cord Injuries; Spinal Cord Ischemia

2021
Pharmacologic prophylactic treatment for perioperative protection of skeletal muscle from ischemia-reperfusion injury in reconstructive surgery.
    Plastic and reconstructive surgery, 2013, Volume: 131, Issue:3

    Topics: Animals; Muscle, Skeletal; Nicorandil; Plastic Surgery Procedures; Postoperative Complications; Reperfusion Injury; Surgical Flaps; Swine; Vasodilator Agents

2013
Nicorandil protects against ischaemia-reperfusion injury in newborn rat kidney.
    Pharmacology, 2013, Volume: 92, Issue:5-6

    Topics: Acute Kidney Injury; Animals; Animals, Newborn; Apoptosis; Cytokines; Disease Models, Animal; Inflammation; KATP Channels; Male; NF-kappa B; Nicorandil; Phosphatidylinositol 3-Kinases; Potassium Channels, Inwardly Rectifying; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents

2013
Nicorandil Protects the Heart from Ischemia/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K/Akt Signaling Pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:6

    Topics: Animals; Apoptosis; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Heart; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction

2015
Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow.
    Journal of the neurological sciences, 2015, Oct-15, Volume: 357, Issue:1-2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Chromones; Circulatory Arrest, Deep Hypothermia Induced; Disease Models, Animal; Down-Regulation; Mice; Morpholines; Neuroprotective Agents; Nicorandil; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reperfusion Injury; Signal Transduction; Up-Regulation

2015
Cardioprotective effect of nicorandil against myocardial injury following cardiac arrest in swine.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:8

    Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Heart Arrest; Injections, Intravenous; Male; Nicorandil; Reperfusion Injury; Swine; Ventricular Fibrillation

2017
The effect of nicorandil on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model.
    The Journal of surgical research, 2011, May-01, Volume: 167, Issue:1

    Topics: Animals; Aspartate Aminotransferases; Glyburide; KATP Channels; L-Lactate Dehydrogenase; Liver; Models, Animal; Nicorandil; Regional Blood Flow; Reperfusion Injury; Swine; Vasodilator Agents

2011
Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney.
    British journal of pharmacology, 2011, Volume: 163, Issue:2

    Topics: Animals; Cromakalim; DNA Damage; Ion Channel Gating; KATP Channels; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Lipid Peroxidation; Male; Nicorandil; Oxidative Stress; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2011
The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:8

    Topics: Animals; Disease Models, Animal; Dogs; Female; Glyburide; Intestine, Small; KATP Channels; Male; Mesenteric Arteries; Nicorandil; Reperfusion Injury; Vasodilator Agents

2011
Nicorandil and leukocyte activation.
    Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:5

    Topics: Animals; Calcium; Cells, Cultured; Heart; Humans; Ischemia; Leukocytes; Microcirculation; Nicorandil; Nitric Oxide; Potassium Channels; Rats; Rats, Wistar; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction

2002
Nicorandil preserves the function of the mitochondrial phosphorylative and oxidative system in an animal model of global ischemia-reperfusion.
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 2007, Volume: 26, Issue:5

    Topics: Animals; Mitochondria; Nicorandil; Oxidative Phosphorylation; Potassium Channels; Rats; Rats, Wistar; Reperfusion Injury

2007
Comparative study on the effects of intracoronary nicorandil and nitroglycerin in ischaemic, reperfused porcine hearts.
    European heart journal, 1995, Volume: 16, Issue:5

    Topics: Animals; Female; Hemodynamics; Injections, Intra-Arterial; Male; Niacinamide; Nicorandil; Nitroglycerin; Oxygen Consumption; Potassium Channels; Reperfusion Injury; Swine; Vasodilator Agents

1995
Antioxidative action of the nitrovasodilator nicorandil: inhibition of oxidative activation of liver microsomal glutathione S-transferase and lipid peroxidation.
    Japanese journal of pharmacology, 1994, Volume: 65, Issue:3

    Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione Transferase; Isosorbide Dinitrate; Lipid Peroxidation; Male; Microsomes, Liver; Niacinamide; Nicorandil; Nitroglycerin; Oxidation-Reduction; Propanolamines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Sympathetic Nervous System; Vasodilator Agents

1994
Nicorandil, a potent adenosine triphosphate-sensitive potassium-channel opener, ameliorates lung allograft reperfusion injury.
    The Journal of thoracic and cardiovascular surgery, 1996, Volume: 112, Issue:5

    Topics: Animals; Dogs; Hemodynamics; Lung; Lung Transplantation; Niacinamide; Nicorandil; Potassium Channels; Reperfusion Injury; Transplantation, Homologous

1996
Effects of nicorandil administration on survival rate and arrhythmias during reperfusion in anesthetized rabbits.
    Pharmacology, 2001, Volume: 63, Issue:3

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Myocardial Ischemia; Nicorandil; Rabbits; Reperfusion Injury; Survival Rate; Time Factors; Tolbutamide

2001
Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.
    Naunyn-Schmiedeberg's archives of pharmacology, 2001, Volume: 364, Issue:5

    Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Gas Analysis; Coronary Disease; Decanoic Acids; Dihydropyridines; Drug Combinations; Hemodynamics; Hydroxy Acids; Male; Myocardial Ischemia; Nicorandil; Potassium Channels; Rabbits; Reperfusion Injury; Survival Rate

2001
Acceleration of recovery of mitochondrial function after coronary reperfusion by various coronary dilating drugs in canine hearts.
    Journal of cardiovascular pharmacology, 1989, Volume: 13, Issue:2

    Topics: Animals; Blood Pressure; Coronary Circulation; Dilazep; Diltiazem; Dogs; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Mitochondria, Heart; Monoamine Oxidase Inhibitors; Niacinamide; Nicorandil; Reperfusion Injury; Vasodilator Agents

1989