nicorandil has been researched along with Myocardial Ischemia in 137 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 50 (36.50) | 18.2507 |
| 2000's | 51 (37.23) | 29.6817 |
| 2010's | 30 (21.90) | 24.3611 |
| 2020's | 6 (4.38) | 2.80 |
| Authors | Studies |
|---|---|
| Hao, L; He, Z; Ming, Z; Shaoqing, L; Ting, Z; Wang, Y | 1 |
| Amano, T; Kobara, M; Nakata, T; Toba, H | 1 |
| Li, H; Li, L; Li, T; Liu, T; Liu, Y; Shu, J; Xie, J | 1 |
| Joo, WJ; Kawakami, K; Miyake, K; Seki, T; Takeuchi, M; Yoshida, S | 1 |
| Ishii, H; Murohara, T | 1 |
| Chen, T; Fang, X; Huang, J; Xu, X; Zhao, Q; Zheng, J; Zhu, H | 1 |
| Hu, W; Lu, Y; Song, Q; Wang, Q | 1 |
| Jiang, X; Jiang, Z; Ling, W; Qian, G; Wu, D | 1 |
| Kobayashi, A; Oikawa, M; Sato, T; Sato, Y; Suzuki, S; Takeishi, Y; Watanabe, S; Yokokawa, T; Yoshihisa, A | 1 |
| Maeba, H; Morishita, S; Shiojima, I; Takehana, K | 1 |
| Graham, MM; Pearson, GJ; Turgeon, RD | 1 |
| Inoue, M; Kawano, H; Kinoshita, M; Kondo, A; Murakami, C | 1 |
| Li, Z; Liu, C; Wang, H; Wang, X; Wang, Y; Xing, Y; Yue, X; Zhang, W; Zhang, X | 1 |
| Gostishchev, RV; Minasyan, AA; Rogoza, AN; Samko, AN; Soboleva, GN | 1 |
| Minushkina, LO; Sidorenko, BA | 1 |
| Chaudhery, B; Lyons, A; Newman, PA | 1 |
| Hopkins, C; Joshi, A; Salim, F | 1 |
| Bu, T; Lu, D; Luo, B; Wu, P; Zeng, Z | 1 |
| Ferdanzi, S; Klein, M; Mandal, A; Paudel, S | 1 |
| Iinuma, S; Miyamoto, S; Nikaido, M | 1 |
| Jacob, JV | 1 |
| Ding, J; Dong, W; Wang, X; Wu, H; Yang, J; Ye, M | 1 |
| Kozlova, NV; Shameeva, ES; Sizova, ZM; Zakharova, VL | 1 |
| Hirose, M; Matsushita, N | 1 |
| Fukushima, Y; Kumita, S; Sato, N; Tokita, Y | 1 |
| Doi, M; Ejiri, K; Enko, K; Hirami, R; Hosogi, S; Ito, H; Kawai, Y; Kohno, K; Mima, A; Miyoshi, T; Munemasa, M; Murakami, M; Nakahama, M; Nakamura, K; Nanba, S; Oka, T; Sakuragi, S; Sato, K; Sato, T; Takahashi, N; Takaishi, A | 1 |
| Arora, R; Jawad, E | 1 |
| Hashimoto, T; Imai, R; Iwamoto, N; Kobayashi, H; Nishida, M; Nishimura, M; Okino, K; Ono, T; Takahashi, H; Tokoro, T; Yamazaki, S | 1 |
| Hirose, M; Horiuchi-Hirose, M; Nakada, T; Tsujino, N; Yamada, M; Yano, S | 1 |
| Horinaka, S; Ishimitsu, T; Kohro, T; Nagai, R; Suzuki, S; Yabe, A; Yagi, H; Yamazaki, T | 1 |
| Galiñanes, M; Lai, VK | 1 |
| Dhayal, G | 1 |
| Asakura, M; Kitakaze, M | 1 |
| Jia, D | 1 |
| Allen, PB; Caddy, GR; Lee, BC; Mainie, I | 1 |
| Agha, AM; Ahmed, LA; Attia, AS; Salem, HA | 1 |
| Payne, CJ; Whitelaw, SC | 1 |
| Ablett, DJ; Berlansky, MS; Wylie, JR | 1 |
| Al-Ozairi, O; Fraser, A; Loudon, M; O'Kelly, T; Watson, A | 1 |
| Adachi, H; Hoshizaki, H; Isobe, N; Naito, S; Nogami, A; Oshima, S; Sugawara, M; Taniguchi, K; Toyama, T | 1 |
| Ichikawa, Y; Kuno, A; Matsumoto, T; Miki, T; Miura, T; Ohnuma, Y; Sakamoto, J; Shimamoto, K; Tanno, M; Tsuchida, A | 1 |
| Mizuno, T; Sakamoto, T; Sunamori, M; Tanaka, H; Watanabe, M | 1 |
| Molloy, RG; Vella, M | 1 |
| Iwase, T; Sakamoto, H; Tamaki, S; Tsubokawa, A; Ueda, K | 1 |
| Greenwood, JP; Jennings, P; Malik, I; Stevenson, RN | 1 |
| Chou, TF; Lee, TM | 1 |
| Das, B; Sarkar, C | 1 |
| Eeckhout, E | 1 |
| Fujiwara, H; Hirose, T; Iwama, M; Matsuno, Y; Matsuo, H; Minatoguchi, S; Segawa, T; Tanaka, S; Tomita, M; Watanabe, S; Yamaki, T; Yasuda, S | 1 |
| Dairaku, Y; Harada, N; Kametani, R; Kawamura, S; Matsuzaki, M; Miura, T; Shibuya, M; Wang, R | 1 |
| Hayashi, Y; Ito, I; Kamibayashi, T; Kawai, Y; Mashimo, T; Matsuda, H; Matsumiya, G; Takahashi, T | 1 |
| Arasaradnam, R; Brown, S; Davies, B; Hunt, LM; Katory, M; Shorthouse, AJ; Skinner, P | 1 |
| Akasaka, T; Fujimoto, K; Kajita, T; Neishi, Y; Ogasawara, Y; Shigeto, F; Watanabe, N; Yoshida, K | 1 |
| Jansen, JO; King, PM; Suttie, SA; Watson, AJ | 1 |
| Edwards, RJ; Lambiase, PD; Marber, MS; Redwood, SR | 1 |
| Chang, NC; Lee, TM; Lin, MS; Tsai, CH | 1 |
| Hatori, T; Ichikawa, S; Kasama, S; Kumakura, H; Kurabayashi, M; Suzuki, T; Takayama, Y; Toyama, T | 1 |
| Kitano, M; Matsui, K; Mori, M; Ogawa, S; Ohashi, N; Yamada, K; Yamamoto, S | 1 |
| Azuma, A; Hashimoto, T; Irie, H; Ito, K; Kinoshita, N; Koide, M; Matsubara, H; Nakamura, R; Sawada, T; Tamaki, S; Taniguchi, T; Yokoi, H | 1 |
| Aoyagi, S; Hayashida, N; Hori, H; Nishi, A; Shojima, T; Takagi, K; Yoshikawa, K | 1 |
| Bassuini, MM; Briggs, CD; Rochester, JR; Toquero, L | 1 |
| Crea, F; Galiuto, L | 1 |
| Arai, M; Bao, N; Chen, XH; Fujiwara, H; Kawamura, I; Kobayashi, H; Lu, C; Minatoguchi, S; Takemura, G; Wang, N; Wu, DJ; Yasuda, S | 1 |
| Aoyama, T; Ichimiya, S; Ishii, H; Kanashiro, M; Kasuga, H; Maruyama, S; Matsubara, T; Matsuo, S; Mitsuhashi, H; Murohara, T; Naruse, K; Takahashi, H; Toriyama, T; Yamada, S | 1 |
| Al-Dulaimi, H; Dodd, H; Majmudar, V | 1 |
| Chaitman, BR; Sano, J | 1 |
| Hirose, M; Imamura, H; Nakada, T; Tsujino, N; Yamada, M; Yano, S | 1 |
| Galiñanes, M; Hearse, DJ; Qiu, Y | 1 |
| Kinoshita, M; Nakae, I; Quan, L; Sugimoto, Y; Tsutamoto, T | 1 |
| Berwing, K; Mitrovic, V; Schlepper, M; Strasser, R; Thormann, J | 1 |
| Fox, K; Knight, C; Purcell, H | 1 |
| Fukui, T; Hibiya, K; Honye, J; Kamata, T; Mizumura, T; Moriuchi, M; Ozawa, Y; Saito, S; Takayama, T; Tamura, Y | 1 |
| Ribeiro, C | 1 |
| Adachi, H; Kodama, K; Mori, N; Saito, I | 1 |
| Shetty, K | 1 |
| Laudisa, ML; Marsico, F; Specchia, G | 1 |
| Das, DK; Hinescu, ME; Leabu, M; Moraru, II; Musat, S; Popescu, A; Popescu, LM; Popescu, M; Tigaret, CM; Trifan, OC | 1 |
| Hosoi, H; Hou, M; Igarashi, M; Iida, M; Ishiguro, S; Koyama, N; Morishita, T; Nakano, H; Yabe, Y; Yamazaki, J | 1 |
| Hellwig, B | 1 |
| Cavero, I; Premmereur, J | 1 |
| Iimura, O; Itoya, M; Iwamoto, T; Miura, T; Shimamoto, K; Urabe, K | 1 |
| Fukasawa, M; Hirooka, S; Minowa, T; Orita, H; Uchino, H; Washio, M | 1 |
| Nakaya, H | 1 |
| Auchampach, JA; Gross, GJ | 1 |
| Suryapranata, H | 1 |
| Auchampach, JA; Gross, GJ; Warltier, DC | 1 |
| Hosoi, H; Iida, M; Komatsu, H; Koyama, N; Morishita, T; Nakano, H; Ohsawa, H; Uchi, T; Yabe, Y; Yamazaki, J | 1 |
| Bloch, G; Grousset, C; Kevelaitis, E; Menasché, P; Mouas, C; Piwnica, A | 1 |
| Branzi, A; Galiè, N; Guarnieri, C; Magnani, B; Parlangeli, R; Traini, AM; Ussia, GP; Vaona, I; Zimarino, M | 1 |
| Asanagi, M; Mitamura, H; Miyazaki, T; Miyoshi, S; Moritani, K; Ogawa, S; Zhao, LS | 1 |
| Grousset, C; Menasché, P; Mouas, C | 1 |
| Miyazaki, T; Miyoshi, S; Moritani, K; Ogawa, S | 1 |
| Györgyi, K; Papp, JG; Parratt, JR; Sakai, K; Vegh, A | 1 |
| Grover, GJ | 2 |
| Chujo, M; Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Chiariello, M; Perrone Filardi, P | 1 |
| Bona, M; Marsico, F; Micheletti, T; Specchia, G | 1 |
| Hanaoka, K; Hayashida, M; Ito, N; Kawamura, S; Komatsu, K; Kuzumi, E; Orii, R; Sawamura, S | 1 |
| Chujo, M; Critz, SD; Downey, JM; Liu, GS | 1 |
| Chang, MS; Chen, JW; Hsu, NW; Lee, WL; Lin, SJ; Ting, CT; Wang, SP | 1 |
| Evans, R; Foex, P; Pigott, D; Piriou, V; Ross, S | 1 |
| André-Fouät, X; Loufoua, J; Minaire, Y; Ovize, M; Pop, C; Rioufol, G | 1 |
| Asanagi, M; Miyazaki, T; Miyoshi, S; Moritani, K; Ogawa, S | 1 |
| Ito, S; Nishikado, A; Sakabe, K; Shinohara, H; Wakatsuki, T | 1 |
| Geshi, E; Ishioka, H; Katagiri, T; Nakatani, M; Nomizo, A | 1 |
| Kamei, K; Kamijo, T; Kamiyama, T; Ohba, Y; Sudo, H; Sugo, I | 1 |
| Fox, KM; Patel, DJ; Purcell, HJ | 1 |
| Brieger, DB; Freedman, SB; Hawkins, R; Rajaratnam, R | 1 |
| Avery, CM; Porter, SR; Scully, C; Shotts, RH | 1 |
| Asakura, K; Hattori, S; Hori, S; Iwanaga, S; Nakamura, Y; Ogawa, S; Shimada, M; Takahashi, M | 1 |
| Chambers, DJ | 1 |
| Ikegaki, I; Sasaki, Y; Uchida, T; Yamamoto, Y | 1 |
| Marbán, E; O'Rourke, B; Sasaki, N; Sato, T | 1 |
| Hayashida, M; Hikawa, Y; Kaneko, T; Saito, Y; Yasuda, K | 1 |
| Adachi, Y; Azuma, A; Hikosaka, T; Ito, K; Katoh, S; Sugihara, H; Yoneyama, S; Zen, K | 1 |
| Obata, T; Yamanaka, Y | 1 |
| Goa, KL; Markham, A; Plosker, GL | 1 |
| Easaw, J; Falase, B; Youhana, A | 1 |
| Hashimura, K; Kato, Y; Kijima, Y; Matsu-ura, Y; Mori, I; Ueda, T; Yasuda, T | 1 |
| Borman, JB; Houminer, E; Li, J; Maulik, D; Olivson, A; Opie, LH; Powell, SR; Schwalb, H; Wahezi, SE | 1 |
| Dairaku, Y; Ikeda, Y; Iwamoto, H; Iwatate, M; Kawamura, S; Kimura, M; Maekawa, T; Matsuzaki, M; Mikami, S; Miura, T; Okamura, T; Tatsuno, H | 1 |
| Hikawa, Y; Kaneko, T; Makita, K; Saito, Y; Yasuda, K | 1 |
| Das, B; Karanth, KS; Sarkar, C | 3 |
| Fox, KM; Gomma, AH; Purcell, HJ | 1 |
| Higgins, CB; Lund, GK; Saeed, M; Watzinger, N; Weinmann, HJ; Wendland, MF | 1 |
| Ertl, G; Horn, M; Hügel, S; Neubauer, S; Schnackerz, KD; Schroeder, M | 1 |
| Chayama, K; Matsuura, H; Sakai, K; Teragawa, H; Yamagata, T | 1 |
| Lesnefsky, EJ | 1 |
| Inoue, R; Iwai, T; Kasahara, S; Motegi, K; Takeo, S; Tanonaka, K | 1 |
| Auchampach, JA; Cavero, I; Gross, GJ | 1 |
| Krumenacker, M; Roland, E | 1 |
| Arakawa, K; Handa, K; Ikeda, K; Kawasaki, K; Saeki, Y; Sasaki, J; Umeno, M | 1 |
23 review(s) available for nicorandil and Myocardial Ischemia
| Article | Year |
|---|---|
Effects of the Antianginal Drugs Ranolazine, Nicorandil, and Ivabradine on Coronary Microvascular Function in Patients With Nonobstructive Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials.
Topics: Angina Pectoris; Cardiovascular Agents; Coronary Artery Disease; Humans; Ivabradine; Myocardial Ischemia; Nicorandil; Randomized Controlled Trials as Topic; Ranolazine; Treatment Outcome | 2019 |
The Efficacy and Safety of Nicorandil for Periprocedural Myocardial Injury in Patients Undergoing PCI: A Meta-Analysis.
Topics: Humans; Intraoperative Complications; Myocardial Ischemia; Nicorandil; Percutaneous Coronary Intervention; Risk Adjustment; Vasodilator Agents | 2020 |
Protective Effect of Nicorandil on Cardiac Microvascular Injury: Role of Mitochondrial Integrity.
Topics: Animals; Humans; Microcirculation; Mitochondria; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicorandil; Oxidative Stress | 2021 |
Pharmacologic Treatment of Patients With Myocardial Ischemia With No Obstructive Coronary Artery Disease.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Cardiovascular Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Ischemia; Nicorandil; Nitrates; Quality of Life; Ranolazine; Vasodilator Agents | 2018 |
[Nicorandil in the treatment of patients with ischemic heart disease].
Topics: Humans; Myocardial Ischemia; Nicorandil; Treatment Outcome; Vasodilator Agents | 2013 |
All-cause mortality and cardiovascular events with nicorandil in patients with IHD: systematic review and meta-analysis of the literature.
Topics: Cardiovascular Diseases; Cause of Death; Humans; Myocardial Ischemia; Nicorandil; Randomized Controlled Trials as Topic; Vasodilator Agents | 2014 |
Chronic stable angina pectoris.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetanilides; Angina Pectoris; Antihypertensive Agents; Benzazepines; Bosentan; Chronic Disease; Counterpulsation; Cyclic Nucleotide-Gated Cation Channels; Exercise Test; Heart Murmurs; Humans; Ivabradine; Myocardial Contraction; Myocardial Ischemia; Myocardial Revascularization; Myocardium; Nicorandil; Oxygen Consumption; Perhexiline; Piperazines; Protein Kinase Inhibitors; Ranolazine; Sulfonamides; Trimetazidine; Vasodilator Agents | 2008 |
Anal ulceration associated with Nicorandil: case series and review of the literature.
Topics: Aged; Aged, 80 and over; Female; Fissure in Ano; Humans; Male; Middle Aged; Myocardial Ischemia; Nicorandil | 2006 |
No-reflow: a heterogeneous clinical phenomenon with multiple therapeutic strategies.
Topics: Adenosine; Animals; Calcium Channel Blockers; Cardiovascular Agents; Coronary Circulation; Coronary Vessels; Humans; Magnetic Resonance Imaging; Microcirculation; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicorandil; Potassium Channels; Randomized Controlled Trials as Topic; Vascular Patency | 2006 |
Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Calcium Channel Blockers; Chronic Disease; Enzyme Inhibitors; Humans; Ivabradine; Myocardial Ischemia; Nicorandil; Nitro Compounds; Piperazines; Ranolazine; rho-Associated Kinases; Sinoatrial Node; Trimetazidine; Vasodilator Agents | 2007 |
Effects of nicorandil on regional perfusion and left ventricular function.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Echocardiography; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Regional Blood Flow; Ventricular Function, Left | 1995 |
Potassium channel openers: clinical applications in ischemic heart disease--overview of clinical efficacy of nicorandil.
Topics: Angina Pectoris; Animals; Anti-Arrhythmia Agents; Hemodynamics; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels | 1995 |
Prescribing for angina.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Nitrates; Vasodilator Agents | 1994 |
[Potassium agonists].
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Humans; Membrane Potentials; Muscle, Smooth, Vascular; Myocardial Ischemia; Neuromuscular Junction; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyrroles; Vascular Resistance; Vasodilator Agents | 1994 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide | 1993 |
Coronary haemodynamics and vasodilatory profile of a potassium channel opener in patients with coronary artery disease.
Topics: Administration, Sublingual; Coronary Circulation; Coronary Disease; Dose-Response Relationship, Drug; Hemodynamics; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Vasodilation; Vasodilator Agents | 1993 |
Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Guanidines; Humans; Ischemic Preconditioning, Myocardial; KATP Channels; Mitochondria, Heart; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Rats | 1997 |
Nicorandil-induced severe oral ulceration: a newly recognized drug reaction.
Topics: Aged; Aged, 80 and over; Cardiovascular Agents; Humans; Male; Myocardial Ischemia; Nicorandil; Oral Ulcer; Potassium Channels | 1999 |
Polarization and myocardial protection.
Topics: Animals; Calcium Channels; Cardiac Surgical Procedures; Cardioplegic Solutions; Female; Heart Arrest, Induced; Humans; Hyperkalemia; Male; Membrane Potentials; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channels; Prognosis; Rabbits; Reperfusion Injury; Sensitivity and Specificity; Survival Rate | 1999 |
Nicorandil. An updated review of its use in ischaemic heart disease with emphasis on its cardioprotective effects.
Topics: Angina Pectoris; Animals; Clinical Trials as Topic; Female; Half-Life; Hemodynamics; Humans; Intestinal Absorption; Male; Myocardial Ischemia; Nicorandil; Potassium Channels; Tissue Distribution; Vasodilator Agents | 2000 |
The role of nicorandil in the treatment of myocardial ischaemia.
Topics: Angina Pectoris; Animals; Coronary Artery Bypass; Coronary Vessels; Hemodynamics; Humans; Myocardial Ischemia; Nicorandil; Potassium Channels; Protective Agents; Vasodilator Agents | 2001 |
Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil.
Topics: Animals; ATP-Binding Cassette Transporters; Humans; Ischemic Preconditioning; KATP Channels; Myocardial Ischemia; Nicorandil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Vasodilator Agents | 2001 |
Clinical profile of nicorandil: an overview of its hemodynamic properties and therapeutic efficacy.
Topics: Diltiazem; Hemodynamics; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1992 |
21 trial(s) available for nicorandil and Myocardial Ischemia
| Article | Year |
|---|---|
Effects of Nicorandil Versus Nitroglycerin on Arterial Oxygenation During Two-Lung Ventilation and One-Lung Ventilation in Patients With Risk Factors for Myocardial Ischemia: A Prospective, Randomized, Double-Blind Study.
Topics: Aged; Aged, 80 and over; Blood Gas Analysis; Double-Blind Method; Female; Humans; Male; Myocardial Ischemia; Nicorandil; Nitroglycerin; One-Lung Ventilation; Prospective Studies; Pulmonary Artery; Risk Factors; Treatment Outcome; Vasodilator Agents | 2019 |
The periprocedural myocardial damage prevention during elective percutaneous coronary intervention as a result of pharmacological preconditioning with an oral form of nicorandil in patients with stable coronary artery disease. Pilot study.
Topics: Aged; Cardiotonic Agents; Coronary Artery Disease; Creatine Kinase, MB Form; Drug Administration Schedule; Elective Surgical Procedures; Female; Humans; Intraoperative Complications; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Percutaneous Coronary Intervention; Pilot Projects; Treatment Outcome; Troponin I | 2018 |
Effect of remote ischemia or nicorandil on myocardial injury following percutaneous coronary intervention in patients with stable coronary artery disease: A randomized controlled trial.
Topics: Aged; Biomarkers; Coronary Artery Disease; Creatine Kinase, MB Form; Female; Humans; Intraoperative Complications; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Percutaneous Coronary Intervention; Postoperative Complications; Treatment Outcome; Troponin T; Vasodilator Agents | 2017 |
Effects of nicorandil on cardiovascular events in patients with coronary artery disease in the Japanese Coronary Artery Disease (JCAD) study.
Topics: Adult; Aged; Aged, 80 and over; Cardiotonic Agents; Coronary Artery Disease; Death, Sudden, Cardiac; Female; Follow-Up Studies; Humans; Incidence; Japan; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Prognosis; Proportional Hazards Models; Registries; Risk Factors; Treatment Outcome | 2010 |
Nicorandil infusion leads to good recovery from ischemia of left ventricular regional work in comparison with nitroglycerin.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Electrocardiography; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Nitroglycerin; Treatment Outcome; Ventricular Dysfunction, Left | 2002 |
Effect of intracoronary nicorandil administration on preventing no-reflow/slow flow phenomenon during rotational atherectomy.
Topics: Aged; Angina Pectoris; Atherectomy, Coronary; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Recurrence; Vasodilator Agents; Verapamil | 2002 |
Evidence of pharmacologic preconditioning during PTCA by intravenous pretreatment with ATP-sensitive K+ channel opener nicorandil.
Topics: Aged; Angioplasty, Balloon, Coronary; Calcium Channel Agonists; Collateral Circulation; Coronary Stenosis; Female; Humans; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Ischemia; Myocardial Revascularization; Nicorandil; Organophosphorus Compounds; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; Vasodilator Agents | 2003 |
Prophylactic effect of intravenous nicorandil on perioperative myocardial damage in patients undergoing off-pump coronary artery bypass surgery.
Topics: Aged; Biomarkers; Carrier Proteins; Coronary Artery Bypass, Off-Pump; Creatine Kinase; Creatine Kinase, MB Form; Fatty Acid-Binding Proteins; Female; Hemodynamics; Humans; Infusions, Intravenous; Isoenzymes; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Perioperative Care; Postoperative Period; Potassium Channels; Troponin T | 2004 |
The effect of an angiotensin-converting enzyme inhibitor and a K+(ATP) channel opener on warm up angina.
Topics: Adaptation, Physiological; Angina Pectoris; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cross-Over Studies; Double-Blind Method; Electrocardiography; Enalapril; Exercise Test; Female; Humans; Ischemic Preconditioning, Myocardial; Losartan; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Potassium Channels; Regression Analysis; Vasodilator Agents | 2005 |
Effect of ischaemic preconditioning on regional release of inflammatory markers.
Topics: Adult; Angioplasty, Balloon, Coronary; Biomarkers; Blood Glucose; CD40 Ligand; Electrocardiography; Female; Glyburide; Hemodynamics; Humans; Inflammation Mediators; Insulin; Ischemic Preconditioning, Myocardial; Lactic Acid; Male; Middle Aged; Myocardial Ischemia; Nicorandil; P-Selectin; Peroxidase; Potassium Channel Blockers; Potassium Channels; Prospective Studies | 2005 |
Comparative effects of nicorandil with isosorbide mononitrate on cardiac sympathetic nerve activity and left ventricular function in patients with ischemic cardiomyopathy.
Topics: Female; Heart; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Sympathetic Nervous System; Ventricular Function, Left | 2005 |
Antiischemic effects of nicorandil during coronary angioplasty in humans.
Topics: Aged; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Blood Pressure; Coronary Angiography; Coronary Vessels; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Niacinamide; Nicorandil; Oxygen Consumption | 1995 |
[Clinical use of potassium channel activators in angina pectoris: efficacy and tolerance].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Humans; Isosorbide Dinitrate; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1995 |
Effects of short-term treatment of nicorandil on exercise-induced myocardial ischemia and abnormal cardiac autonomic activity in microvascular angina.
Topics: Administration, Oral; Aged; Angina Pectoris; Coronary Angiography; Cross-Over Studies; Double-Blind Method; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Conduction System; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Niacinamide; Nicorandil; Reproducibility of Results; Vasodilator Agents | 1997 |
Cardioprotection by opening of the K(ATP) channel in unstable angina. Is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil. CESAR 2 investigation. Clinical European studies in angina and revasculari
Topics: Adenosine Triphosphate; Administration, Oral; Adult; Aged; Aged, 80 and over; Angina, Unstable; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Double-Blind Method; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart; Humans; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Potassium Channels; Retrospective Studies; Safety; Treatment Outcome | 1999 |
Attenuation of anti-ischemic efficacy during chronic therapy with nicorandil in patients with stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Double-Blind Method; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Time Factors; Verapamil | 1999 |
[The effect of prophylactic nicorandil infusion to reduce intraoperative myocardial ischemia during abdominal surgery in patients with risk factors of ischemic heart disease].
Topics: Abdomen; Adult; Double-Blind Method; Electrocardiography; Female; Humans; Intraoperative Care; Intraoperative Complications; Male; Middle Aged; Monitoring, Intraoperative; Myocardial Ischemia; Nicorandil; Risk Factors; Vasodilator Agents | 2000 |
Nicorandil, a hybrid between nitrate and ATP-sensitive potassium channel opener, preconditions human heart to ischemia during percutaneous transluminal coronary angioplasty.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Electrocardiography; Female; Humans; Ischemic Preconditioning, Myocardial; Lactic Acid; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Premedication; Vasodilator Agents | 2001 |
Dose-dependent prophylactic effect of nicorandil, an ATP-sensitive potassium channel opener, on intra-operative myocardial ischaemia in patients undergoing major abdominal surgery.
Topics: Abdomen; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Intraoperative Complications; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Postoperative Complications; Prospective Studies; Risk Factors; Vasodilator Agents | 2001 |
Nicorandil enhances myocardial tolerance to ischemia without progressive collateral recruitment during coronary angioplasty.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Chest Pain; Collateral Circulation; Electrocardiography; Female; Heart; Humans; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Patient Selection; Vasodilator Agents | 2002 |
A multicenter comparison of nicorandil and diltiazem on serum lipid, apolipoprotein, and lipoprotein levels in patients with ischemic heart disease.
Topics: Aged; Apolipoproteins; Diltiazem; Female; Humans; Lipids; Lipoproteins; Male; Middle Aged; Myocardial Ischemia; Niacinamide; Nicorandil; Vasodilator Agents | 1992 |
93 other study(ies) available for nicorandil and Myocardial Ischemia
| Article | Year |
|---|---|
Nicorandil, an ATP-sensitive potassium channel activation, attenuates myocardial injury in rats with ischemic cardiomyopathy.
Topics: Animals; Cardiomyopathies; KATP Channels; Myocardial Ischemia; Myocardium; Nicorandil; Rats | 2022 |
Nicorandil Suppresses Ischemia-Induced Norepinephrine Release and Ventricular Arrhythmias in Hypertrophic Hearts.
Topics: Animals; Arrhythmias, Cardiac; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Norepinephrine; Potassium Channels; Rats | 2023 |
Nicorandil protects against coronary microembolization-induced myocardial injury by suppressing cardiomyocyte pyroptosis via the AMPK/TXNIP/NLRP3 signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Cell Cycle Proteins; Heart Injuries; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nicorandil; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Rats; Signal Transduction | 2022 |
Effectiveness of intraoperative nicorandil in patients with a history of ischemic heart disease undergoing high-risk noncardiac surgery: a retrospective cohort study.
Topics: Hospital Mortality; Humans; Intraoperative Care; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Percutaneous Coronary Intervention; Retrospective Studies; Surgical Procedures, Operative | 2023 |
How Do We Improve the Utility of Fractional Flow Reserve? - For Precise Diagnosis of Myocardial Ischemia.
Topics: Coronary Artery Disease; Coronary Stenosis; Fractional Flow Reserve, Myocardial; Humans; Myocardial Ischemia; Nicorandil | 2019 |
Decreased cardiac mortality with nicorandil in patients with ischemic heart failure.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Female; Heart Failure; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Proportional Hazards Models; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; Vasodilator Agents | 2017 |
Nicorandil was an Effective Treatment Option for a Patient with Bland-White-Garland Syndrome.
Topics: Aged; Bland White Garland Syndrome; Female; Heart Failure; Humans; Myocardial Ischemia; Nicorandil; Treatment Outcome; Vasodilator Agents | 2017 |
Protective Effects of Nicorandil on Cardiac Function and Left Ventricular Remodeling in a Rat Model of Ischemic Heart Failure.
Topics: Animals; bcl-2-Associated X Protein; Cardiotonic Agents; Heart Failure; Heart Ventricles; Male; Myocardial Ischemia; Myocardium; Nicorandil; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2018 |
De novo rectovaginal fistulation and multisite ulceration as a consequence of nicorandil therapy.
Topics: Aged; Female; Humans; Myocardial Ischemia; Nicorandil; Rectovaginal Fistula; Ulcer; Vasodilator Agents; Vulvar Diseases | 2014 |
Ulceration of the nasal dorsum: a rare cause?
Topics: Debridement; Gingiva; Humans; Male; Middle Aged; Mouth; Myocardial Ischemia; Nicorandil; Nose; Pemphigus; Treatment Outcome; Ulcer; Vasodilator Agents | 2014 |
Nicorandil-associated skin necrosis around a stoma site.
Topics: Aged, 80 and over; Colostomy; Female; Humans; Intestinal Obstruction; Myocardial Ischemia; Nicorandil; Postoperative Complications; Skin Ulcer; Surgical Stomas; Treatment Outcome; Vasodilator Agents; Withholding Treatment | 2014 |
Systemic ulcerative lesions in a patient with ischemic heart disease.
Topics: Aged, 80 and over; Anal Canal; Colitis, Ulcerative; Eyelid Diseases; Female; Humans; Myocardial Ischemia; Nicorandil; Vasodilator Agents | 2014 |
Nicorandil-induced colonic ulceration.
Topics: Aged; Colitis, Ulcerative; Colon, Ascending; Colonoscopy; Diagnosis, Differential; Female; Humans; Ileocecal Valve; Myocardial Ischemia; Nicorandil; Vasodilator Agents | 2015 |
Nicorandil Protects the Heart from Ischemia/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K/Akt Signaling Pathway.
Topics: Animals; Apoptosis; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Heart; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2015 |
[Comparative Assessment of Effects of Isosorbide Dinitrate, Isosorbide-5-Mononitrate and Nicorandil on the Frequency of Angina Attacks and Vasoregulating Endothelial Function in Patients With Ischemic Heart Disease].
Topics: Adult; Aged; Angina Pectoris; Electrocardiography; Female; Humans; Incidence; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Risk Assessment; Russia; Vasodilation | 2015 |
Roles of ATP-sensitive K＋ channels in the prevention of ischemia-induced cardiac tachyarrhythmia.
Topics: Animals; Atrial Remodeling; Dogs; KATP Channels; Myocardial Ischemia; Nicorandil; Tachycardia | 2015 |
Prognostic Value of Myocardial Perfusion SPECT After Intravenous Bolus Administration of Nicorandil in Patients with Acute Ischemic Heart Failure.
Topics: Aged; Aged, 80 and over; Exercise Test; Female; Heart; Heart Failure; Humans; Kaplan-Meier Estimate; Male; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardium; Nicorandil; Positron-Emission Tomography; Prognosis; Rest; Risk Factors; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 2016 |
Clinical potential of nicorandil to inhibit major cardiac events in hemodialysis patients with suspected myocardial ischemia.
Topics: Aged; Death; Female; Follow-Up Studies; Humans; Kidney Diseases; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Renal Dialysis | 2009 |
Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Topics: Action Potentials; Animals; Coronary Vessels; Disease Models, Animal; Dogs; Heart Atria; Heart Conduction System; Myocardial Ischemia; Nicorandil; Perfusion | 2011 |
Protection of human myocardium by bone marrow cells: role of long-term administration of the mitochondrial K(ATP) channel opener nicorandil.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Atrial Appendage; Bone Marrow Cells; Cardiotonic Agents; Cell Communication; Humans; In Vitro Techniques; Middle Aged; Myocardial Ischemia; Necrosis; Nicorandil; Potassium Channels; Vasodilator Agents | 2011 |
Cardiac cephalgia and cardiac migraine.
Topics: Aged; Electrocardiography; Headache Disorders, Secondary; Humans; Male; Migraine Disorders; Myocardial Ischemia; Nicorandil; Vasodilator Agents | 2010 |
Cardioprotection in the clinical setting-lessons from J-WIND studies.
Topics: Atrial Natriuretic Factor; Cardiotonic Agents; Disease Progression; Heart Failure; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicorandil; Randomized Controlled Trials as Topic; Risk Factors; Vasodilator Agents | 2010 |
The protective effect of mitochondrial ATP-sensitive K+ channel opener, nicorandil, combined with Na+/Ca2+ exchange blocker KB-R7943 on myocardial ischemia-reperfusion injury in rat.
Topics: Animals; Anti-Arrhythmia Agents; Female; In Vitro Techniques; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nicorandil; Potassium Channels; Rats; Rats, Wistar; Sodium-Calcium Exchanger; Superoxide Dismutase; Thiourea | 2011 |
Nicorandil associated colonic ulceration: case series of an increasingly recognized complication.
Topics: Aged; Aged, 80 and over; Biopsy; Colonic Diseases; Colonoscopy; Female; Humans; Male; Myocardial Ischemia; Nicorandil; Treatment Outcome; Ulcer; Vasodilator Agents | 2011 |
Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats.
Topics: Animals; Arrhythmias, Cardiac; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicorandil; Pioglitazone; Rats; Rats, Wistar; Thiazolidinediones | 2011 |
Colonic and parastomal ulceration related to nicorandil.
Topics: Aged; Aged, 80 and over; Colonic Diseases; Colonoscopy; Colostomy; Diagnosis, Differential; Diverticulum, Colon; Female; Follow-Up Studies; Humans; Male; Myocardial Ischemia; Nicorandil; Ulcer; Vasodilator Agents | 2011 |
Perianal actinomycosis: a case study of this rare infection associated with nicorandil usage.
Topics: Actinomycosis; Aged; Anus Diseases; Humans; Male; Myocardial Ischemia; Nicorandil; Treatment Outcome; Ulcer; Vasodilator Agents; Wound Healing | 2012 |
Nicorandil associated anal ulceration.
Topics: Aged; Aged, 80 and over; Female; Fissure in Ano; Humans; Male; Myocardial Ischemia; Nicorandil; Vasodilator Agents | 2002 |
Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C.
Topics: Animals; Benzamides; Decanoic Acids; Enzyme Inhibitors; Glycine; Hemodynamics; Hydroxy Acids; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Naphthalenes; Nicorandil; Potassium Channels; Protein Kinase C; Rabbits; Sarcolemma; Sulfhydryl Compounds | 2002 |
2-Nicotinamidoethyl nitrale (2-NN) protects myocardium in ischemia and reperfusion via the protein kinase C pathway.
Topics: Animals; Coronary Circulation; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Heart Function Tests; Hemodynamics; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Naphthalenes; Nicorandil; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity | 2002 |
Nicorandil-associated anal ulceration.
Topics: Aged; Fatal Outcome; Female; Fissure in Ano; Humans; Male; Myocardial Ischemia; Nicorandil; Vasodilator Agents | 2002 |
Haemodynamic and electrocardiographic consequences of severe nicorandil toxicity.
Topics: Adult; Blood Pressure; Coronary Disease; Electrocardiography; Humans; Hypotension; Myocardial Ischemia; Nicorandil; Vasodilator Agents | 2003 |
Impairment of myocardial protection in type 2 diabetic patients.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Pressure; Chest Pain; Diabetes Mellitus, Type 2; Electrocardiography; Female; Glyburide; Heart Rate; Humans; Hypoglycemic Agents; Ischemic Preconditioning; Lactic Acid; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Potassium Channels; Prospective Studies; Sulfonylurea Compounds; Vasodilator Agents | 2003 |
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids; Electrocardiography; Heart Rate; Hydroxy Acids; Ion Channel Gating; Male; Membrane Proteins; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nicorandil; Oxidative Stress; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits; Sarcolemma; Sulfonamides; Survival Rate; Thiourea | 2003 |
Nicorandil: a drug for many purposes: too good to be true?
Topics: Angina Pectoris; Cardiomyopathy, Hypertrophic; Humans; Myocardial Ischemia; Nicorandil; Vasodilator Agents | 2003 |
NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels.
Topics: Animals; Antihypertensive Agents; Diazoxide; Enzyme Activation; Heart Rate; Isoenzymes; Membrane Proteins; Myocardial Ischemia; Nicorandil; Nitric Oxide; Potassium Channels; Protein Kinase C; Protein Kinase C-delta; Rats; Rats, Sprague-Dawley | 2004 |
Nicorandil associated anal ulceration.
Topics: Anus Diseases; Colonoscopy; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Intestinal Mucosa; Male; Myocardial Ischemia; Nicorandil; Risk Assessment; Sampling Studies; Severity of Illness Index; Ulcer | 2004 |
Effect of nicorandil, a K+ATP -channel opener, on coronary capillary architecture and volume after early myocardial ischemia-reperfusion--a 3-dimensional confocal laser microscopic study--.
Topics: Adenosine Triphosphate; Animals; Capillaries; Coronary Vessels; Imaging, Three-Dimensional; In Vitro Techniques; Male; Microscopy, Confocal; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicorandil; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents | 2004 |
Perforation of the terminal ileum: a possible complication of nicorandil therapy.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Ileal Diseases; Intestinal Perforation; Laparotomy; Middle Aged; Myocardial Ischemia; Nicorandil; Risk Assessment; Treatment Outcome; Ulcer | 2004 |
Reduction of myocardial infarct size by SM-197378, a novel Na+/H+ exchange inhibitor, in rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart; Heart Rate; Indoles; Ischemic Preconditioning; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nicorandil; Rabbits; Sodium-Hydrogen Exchangers; Time Factors; Vasodilator Agents | 2005 |
[Clinical usefulness of 1231I-BMIPP myocardial SPECT in patient with microvascular spasm: a case report].
Topics: Coronary Circulation; Coronary Vasospasm; Electrocardiography; Fatty Acids; Heart; Humans; Iodobenzenes; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 2006 |
Effects of nicorandil preconditioning on membrane dystrophin.
Topics: Animals; Coronary Circulation; Creatine Kinase; Dystrophin; Fluorescent Antibody Technique; Heart; Heart Arrest, Induced; Immunoblotting; Ischemic Preconditioning, Myocardial; Microscopy, Confocal; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Nicorandil; Potassium Channels; Rats; Sarcolemma; Vasodilator Agents; Vinculin | 2006 |
Nicorandil improves post-ischemic myocardial dysfunction in association with opening the mitochondrial K(ATP) channels and decreasing hydroxyl radicals in isolated rat hearts.
Topics: Animals; Heart Ventricles; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Male; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2006 |
Efficacy of oral nicorandil in patients with end-stage renal disease: a retrospective chart review after coronary angioplasty in Japanese patients receiving hemodialysis.
Topics: Administration, Oral; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Female; Humans; Japan; Kidney Failure, Chronic; Male; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Nicorandil; Prognosis; Renal Dialysis; Retrospective Studies; Risk Factors; Survival Rate; Treatment Outcome; Vasodilator Agents | 2007 |
Lichenoid drug eruption secondary to treatment with nicorandil?
Topics: Drug Eruptions; Female; Humans; Lichen Planus; Middle Aged; Myocardial Ischemia; Nicorandil; Treatment Outcome; Vasodilator Agents | 2008 |
Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzamides; Disease Models, Animal; Dogs; Drug Antagonism; Electric Stimulation; Heart Ventricles; Male; Myocardial Ischemia; Nicorandil; Organ Culture Techniques; Perfusion; Spectrometry, Fluorescence; Tachycardia; Ventricular Dysfunction, Left | 2008 |
Protective effect of nicorandil as an additive to the solution for continuous warm cardioplegia.
Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Dose-Response Relationship, Drug; Heart; Heart Arrest, Induced; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Rats; Rats, Wistar; Ventricular Fibrillation | 1995 |
Glibenclamide-induced oscillation of canine coronary artery is independent of myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Diltiazem; Dogs; Female; Glyburide; In Vitro Techniques; Male; Muscle Tonus; Muscle, Smooth, Vascular; Myocardial Ischemia; Niacinamide; Nicorandil; Nitroarginine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
[Therapeutic application of myocardial cytoprotection].
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Carnitine; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents | 1994 |
Effects of a novel, selective and potent phosphodiesterase type V inhibitor, E4021, on myocardial ischemia in guinea pigs.
Topics: Animals; Drug Interactions; Electrocardiography; Guinea Pigs; Injections, Intravenous; Isosorbide Dinitrate; Male; Myocardial Ischemia; Niacinamide; Nicorandil; Nitro Compounds; Phosphodiesterase Inhibitors; Piperidines; Quinazolines; Vasodilator Agents; Vasopressins | 1994 |
[K-channel activators and cardioprotection].
Topics: Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels | 1993 |
K(+)-channel openers protect the myocardium against ischemia-reperfusion injury.
Topics: Animals; In Vitro Techniques; Lipid Metabolism; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Picolines; Potassium Channels; Pyrans; Rats | 1994 |
Evaluation of the efficacy of nicorandil in patients with ischemic heart disease by exercise Tl-201 myocardial SPECT.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Antihypertensive Agents; Coronary Angiography; Coronary Artery Bypass; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Niacinamide; Nicorandil; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 1994 |
Evolving Issues in the Treatment of Ischaemic Heart Disease: The Potassium Channel Openers. Symposium proceedings. Barcelona, Spain, 2 September 1992.
Topics: Animals; Anti-Arrhythmia Agents; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels | 1993 |
ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease.
Topics: Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Humans; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1994 |
Effect of nicorandil on post-ischaemic contractile dysfunction in the heart: roles of its ATP-sensitive K+ channel opening property and nitrate property.
Topics: Adenosine Triphosphate; Animals; Glyburide; Hemodynamics; Infusions, Intravenous; Ion Channel Gating; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Niacinamide; Nicorandil; Nitrates; Nitroglycerin; Potassium Channels; Premedication; Rabbits; Vasodilator Agents | 1993 |
Prevention of postischemic reperfusion injury: the improvement of myocardial tissue blood flow after ischemia by terminal nicorandil-Mg cardioplegia.
Topics: Animals; Blood Flow Velocity; Carbon Dioxide; Cardioplegic Solutions; Coronary Vessels; Dogs; Glucose; Magnesium; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Oxygen Consumption; Partial Pressure; Vasodilator Agents | 1993 |
Anti-ischaemic actions of potassium channel openers in experimental myocardial ischaemia/reperfusion injury in dogs.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Picolines; Potassium; Potassium Channels; Pyrans; Vasodilator Agents | 1993 |
Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Dogs; Glyburide; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1993 |
Study of the efficacy of nicorandil in patients with ischaemic heart disease using Exercise-T1-201 myocardial tomography.
Topics: Adult; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Coronary Artery Bypass; Coronary Circulation; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Niacinamide; Nicorandil; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 1993 |
Preconditioning with potassium channel openers. A new concept for enhancing cardioplegic protection?
Topics: Animals; Coronary Circulation; Glyburide; Heart Arrest, Induced; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Wistar; Ventricular Function, Left | 1995 |
Limitation of myocardial infarct size by nicorandil after sustained ischemia in pigs.
Topics: Animals; Blood Pressure; Cardiac Output; Female; Glutathione; Heart Rate; Isosorbide Dinitrate; Male; Malondialdehyde; Myocardial Infarction; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Peroxidase; Potassium Channels; Pulmonary Wedge Pressure; Swine; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left | 1995 |
Nicorandil augments regional ischemia-induced monophasic action potential shortening and potassium accumulation without serious proarrhythmia.
Topics: Action Potentials; Animals; Coronary Circulation; Dogs; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium; Potassium Channels; Vasodilator Agents; Ventricular Fibrillation | 1995 |
Is potassium channel opening an effective form of preconditioning before cardioplegia?
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiac Volume; Cardioplegic Solutions; Coronary Circulation; Heart Arrest, Induced; Hyperthermia, Induced; Ion Channel Gating; Male; Monoamine Oxidase Inhibitors; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium Channels; Potassium Chloride; Preoperative Care; Rats; Rats, Wistar; Ventricular Function, Left | 1996 |
Different responses of epicardium and endocardium to KATP channel modulators during regional ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Decanoic Acids; Dogs; Endocardium; Hydroxy Acids; Myocardial Ischemia; Niacinamide; Nicorandil; Osmolar Concentration; Pericardium; Potassium; Potassium Channel Blockers; Potassium Channels; Reaction Time | 1996 |
Nicorandil suppressed ventricular arrhythmias in a canine model of myocardial ischaemia.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Circulation; Dogs; Electrocardiography; Female; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Nitric Oxide; Vascular Resistance; Vasodilator Agents | 1996 |
Mechanisms of action of various ATP-sensitive potassium channel openers.
Topics: Adenosine Triphosphate; Animals; Dogs; Ion Channel Gating; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Rats; Vasodilator Agents | 1996 |
Role of activation of ectosolic 5'-nucleotidase in the cardioprotection mediated by opening of K+c channels.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Enzyme Activation; Glyburide; Heart; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Recurrence | 1996 |
[Potassium channel activators: hemodynamic effects at the systemic and coronary level].
Topics: Animals; Coronary Circulation; Hemodynamics; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1995 |
[Successful treatment of intraoperative myocardial ischemia with nicorandil].
Topics: Aged; Aged, 80 and over; Anesthesia; Female; Humans; Injections, Intravenous; Intraoperative Complications; Male; Middle Aged; Myocardial Ischemia; Niacinamide; Nicorandil; Vasodilator Agents | 1997 |
Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes.
Topics: Adenosine Triphosphate; Animals; Cell Death; Disease Models, Animal; Electrophysiology; Female; Guanidines; Heart; Heart Ventricles; Male; Myocardial Ischemia; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Rabbits; Vasodilator Agents | 1997 |
Beneficial effect of concomitant administration of isoflurane and nicorandil.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Drug Therapy, Combination; Female; Fentanyl; Hemodynamics; Isoflurane; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Rabbits; Vasodilator Agents; Ventricular Function, Left | 1997 |
Ventricular fibrillation in preconditioned pig hearts: role of K+ATP channels.
Topics: Action Potentials; Animals; Blood Glucose; Blood Pressure; Glyburide; Heart; Heart Rate; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium Channel Blockers; Potassium Channels; Swine; Time Factors; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Differential role of epicardial and endocardial K(ATP) channels in potassium accumulation during regional ischemia induced by embolization of a coronary artery with latex.
Topics: Adenosine Triphosphate; Algorithms; Animals; Coronary Vessels; Dogs; Embolization, Therapeutic; Endocardium; Glyburide; Microelectrodes; Microspheres; Myocardial Ischemia; Niacinamide; Nicorandil; Pericardium; Potassium; Potassium Channel Blockers; Potassium Channels; Vasodilator Agents | 1998 |
The effects of nicorandil on electrophysiological changes in acute myocardial ischemia and reperfusion.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Electrophysiology; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Ventricular Fibrillation | 1998 |
Biochemical and ultrastructural evaluations of the effect of ischemic preconditioning on ischemic myocardial injury--role of the adenosine triphosphate-sensitive potassium channel.
Topics: Adenosine Triphosphate; Animals; Blood Flow Velocity; Calcium-Transporting ATPases; Coronary Vessels; Dogs; Electrophoresis, Polyacrylamide Gel; Glyburide; Hemodynamics; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Contraction; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channels; Sarcoplasmic Reticulum | 1998 |
Hemodynamic and hormonal responses to nicorandil in a canine model of acute ischemic heart failure: a comparison with cromakalim and nitroglycerin.
Topics: Acute Disease; Animals; Atrial Natriuretic Factor; Cardiac Output, Low; Cromakalim; Dogs; Embolization, Therapeutic; Female; Hemodynamics; Hormones; Male; Microspheres; Myocardial Ischemia; Natriuretic Peptide, Brain; Nicorandil; Nitroglycerin; Potassium Channels; Renin; Vasodilator Agents | 1999 |
Nonischemic ST-segment elevation induced by negative inotropic agents.
Topics: Adenosine; Animals; Depression, Chemical; Dogs; Dyskinesia, Drug-Induced; Electrocardiography; Female; Hemodynamics; Lidocaine; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Nicorandil; Nitroglycerin; Ventricular Dysfunction, Left | 1999 |
The protein kinase inhibitor fasudil protects against ischemic myocardial injury induced by endothelin-1 in the rabbit.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Movement; Diltiazem; Electrocardiography; Endothelin-1; Enzyme Inhibitors; Heart Ventricles; Macrophages; Male; Microscopy; Myocardial Ischemia; Necrosis; Neutrophils; Nicorandil; Nifedipine; Papillary Muscles; Rabbits; Random Allocation; Vasodilator Agents | 2000 |
Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Flavoproteins; Fluorescence; Heart Ventricles; Mitochondria, Heart; Myocardial Ischemia; Nicorandil; Potassium Channels; Rabbits; Vasodilator Agents | 2000 |
[Two cases of microvascular vasospastic angina usefulness of 99mTc-tetrofosmin myocardial SPECT in clinical diagnosis].
Topics: Calcium Channel Blockers; Diltiazem; Female; Heart; Humans; Male; Microvascular Angina; Middle Aged; Myocardial Ischemia; Nicorandil; Organophosphorus Compounds; Organotechnetium Compounds; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Vasodilator Agents | 2000 |
Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Ferrous Compounds; Glyburide; Hydroxy Acids; Hydroxybenzoates; Hydroxyl Radical; Hypoglycemic Agents; Inhibitory Concentration 50; Iron Chelating Agents; Male; Microdialysis; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channel Blockers; Rats; Rats, Wistar; Salicylates; Time Factors | 2000 |
Nicorandil decreases postischemic actin oxidation.
Topics: Actins; Animals; Anti-Arrhythmia Agents; Free Radicals; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardial Ischemia; Nicorandil; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2001 |
Ischemic preconditioning attenuates cardiac sympathetic nerve injury via ATP-sensitive potassium channels during myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Desipramine; Dialysis Solutions; Diltiazem; Dogs; Glyburide; Heart; Hemodynamics; Ischemic Preconditioning; Myocardial Ischemia; Nicorandil; Norepinephrine; Potassium Channels; Sympathetic Nervous System; Time Factors | 2001 |
Effects of nicorandil administration on survival rate and arrhythmias during reperfusion in anesthetized rabbits.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Myocardial Ischemia; Nicorandil; Rabbits; Reperfusion Injury; Survival Rate; Time Factors; Tolbutamide | 2001 |
Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Gas Analysis; Coronary Disease; Decanoic Acids; Dihydropyridines; Drug Combinations; Hemodynamics; Hydroxy Acids; Male; Myocardial Ischemia; Nicorandil; Potassium Channels; Rabbits; Reperfusion Injury; Survival Rate | 2001 |
Assessment of nicorandil therapy in ischemic myocardial injury by using contrast-enhanced and functional MR imaging.
Topics: Animals; Contrast Media; Echo-Planar Imaging; Gadolinium DTPA; Magnetic Resonance Imaging; Mesoporphyrins; Myocardial Infarction; Myocardial Ischemia; Myocardium; Nicorandil; Rats; Vasodilator Agents; Ventricular Function, Left | 2001 |
Mechanisms of the effects of nicorandil in the isolated rat heart during ischemia and reperfusion: a 31P-nuclear magnetic resonance study.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Glyburide; Heart; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Nicorandil; Phosphorus; Potassium Channels; Rats; Rats, Wistar | 2001 |
Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressure; Decanoic Acids; Heart Rate; Hemodynamics; Hydroxy Acids; Male; Membrane Proteins; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicorandil; Potassium Channels; Rabbits; Severity of Illness Index | 2002 |
The IONA study: preparing the myocardium for ischaemia?
Topics: Aged; Anti-Arrhythmia Agents; Chronic Disease; Humans; Myocardial Ischemia; Nicorandil; Potassium Channels, Calcium-Activated | 2002 |
Nicorandil preserves mitochondrial function during ischemia in perfused rat heart.
Topics: Animals; Cardiovascular Agents; Cell Hypoxia; Cytochrome c Group; Energy Metabolism; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicorandil; Oxygen Consumption; Rats; Rats, Wistar; Ventricular Function, Left | 2002 |
Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Coronary Circulation; Dogs; Female; Glyburide; Heart; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Ventricular Function, Left | 1992 |
Evolving Issues in the Treatment of Angina Pectoris. Nicorandil: The 1st Potassium-Channel Activator in Ischemic Heart Disease. Proceedings of an International Workshop. Taormina, Sicily, May 8-12, 1991.
Topics: Animals; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels | 1992 |