Compounds > nicorandil
Page last updated: 2024-08-23

nicorandil and Injury, Ischemia-Reperfusion

nicorandil has been researched along with Injury, Ischemia-Reperfusion in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.57)18.7374
1990's4 (14.29)18.2507
2000's7 (25.00)29.6817
2010's9 (32.14)24.3611
2020's7 (25.00)2.80

Authors

AuthorsStudies
Erlitz, L; Hardi, P; Ibitamuno, C; Jancsó, G; Kasza, B; Sétáló, G; Takács, I; Telek, V; Vecsernyés, M1
Abe, K; Enzan, K; Horiguchi, T; Kimura, T; Masaki, Y; Nishikawa, T1
Abdel-Gaber, SA; Abdel-Hafez, SMN; Abdelzaher, WY; Atta, M1
Bigdeli, MR; Namavar, MR; Owjfard, M; Safari, A1
Aftab, M; Cheng, L; Cleveland, JC; Fullerton, DA; Ghincea, CV; Ikeno, Y; Meng, X; Reece, TB; Roda, GF; Weyant, MJ2
Gu, X; Ma, Z; Wu, M1
Ashrafpour, H; Cahoon, NJ; Forrest, CR; Hofer, SOP; Huang, N; Lipa, JE; Naparus, A; Pang, CY1
Tian, ZL; Yao, L; Zhang, AQ; Zhang, YJ; Zhao, XX1
Ding, J; Dong, W; Wang, X; Wu, H; Yang, J; Ye, M1
Fan, C; Feng, Y; Hu, L; Mo, X; Wen, Z; Yang, L; Yin, KJ; Yu, D; Zhang, W1
Chen, JB; Hou, ZQ; Hu, HR; Ji, XF; Liang, LN; Shang, DY; Zhong, X; Zhou, Y; Zhu, FF1
Hirai, K; Kobayashi, K; Matsumoto, K; Odawara, H; Oshima, K; Sato, H; Suto, Y; Takeyoshi, I; Yamazaki, H1
Dimitriadis, F; Hayashi, A; Kinoshita, Y; Ohmasa, F; Saito, M; Satoh, K; Shimizu, S; Shomori, K1
Arakawa, K; Matsumoto, K; Oshima, K; Sato, H; Suto, Y; Takeyoshi, I; Yamazaki, H1
Li, ST; Wang, ZP; Xia, YF; Yan, T; Zhou, YC1
Fukuda, S; Ikeda, N; Imai, N; Ishizuka, N; Kawakami, M; Kuroki, M; Matsuda, E; Saito, M; Schmid-Schönbein, GW; Ueba, H; Yasu, T1
Asakura, M; Asanuma, H; Jiyoong, K; Kitakaze, M; Minamino, T; Shintani, Y1
Endo, S; Inada, K; Kadosaki, M; Kawamura, T; Nara, N; Wei, J1
Carreira, R; Gonçalves, LM; Monteiro, P; Providência, LA1
Asakura, M; Asanuma, H; Fujii, K; Fukuzawa, S; Hamasaki, T; Hirayama, A; Ishihara, M; Kim, J; Kimura, K; Kitakaze, M; Kitamura, S; Minamino, T; Myoishi, M; Nagai, Y; Nakamura, N; Nanto, S; Ohara, T; Saito, Y; Seguchi, O; Shintani, Y; Tomoike, H; Watanabe, K1
Klein, HH; Lindert-Heimberg, S; Maisch, B; Nebendahl, K; Pich, S; Schade-Brittinger, C1
Aniya, Y; Naito, A; Sakanashi, M1
Cooper, JD; Fujino, S; Patterson, GA; Schmid, RA; Yamashita, M1
Chambers, DJ1
Das, B; Karanth, KS; Sarkar, C2
Ajioka, M; Fukushima, A; Hanaki, Y; Kondo, T; Ozawa, T; Sugiyama, S1

Reviews

2 review(s) available for nicorandil and Injury, Ischemia-Reperfusion

ArticleYear
Mitochondrial Quality Control in Cerebral Ischemia-Reperfusion Injury.
    Molecular neurobiology, 2021, Volume: 58, Issue:10

    Topics: Animals; Antioxidants; Brain Ischemia; Humans; Ischemic Stroke; Mitochondria; Mitochondrial Dynamics; Mitophagy; Nicorandil; Reperfusion Injury; Vasodilator Agents

2021
Polarization and myocardial protection.
    Current opinion in cardiology, 1999, Volume: 14, Issue:6

    Topics: Animals; Calcium Channels; Cardiac Surgical Procedures; Cardioplegic Solutions; Female; Heart Arrest, Induced; Humans; Hyperkalemia; Male; Membrane Potentials; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channels; Prognosis; Rabbits; Reperfusion Injury; Sensitivity and Specificity; Survival Rate

1999

Trials

4 trial(s) available for nicorandil and Injury, Ischemia-Reperfusion

ArticleYear
Cerebral protective effect of nicorandil premedication on patients undergoing liver transplantation.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2012, Volume: 11, Issue:2

    Topics: Administration, Oral; Brain Injuries; Humans; Intelligence Tests; KATP Channels; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Nerve Growth Factors; Nicorandil; Phosphopyruvate Hydratase; Reperfusion Injury; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Treatment Outcome

2012
Rationale and design of a large-scale trial using nicorandil as an adjunct to percutaneous coronary intervention for ST-segment elevation acute myocardial infarction: Japan-Working groups of acute myocardial infarction for the reduction of Necrotic Damage
    Circulation journal : official journal of the Japanese Circulation Society, 2004, Volume: 68, Issue:2

    Topics: Adult; Aged; Biomarkers; Cardiac Surgical Procedures; Clinical Protocols; Creatine Kinase; Data Collection; Electrocardiography; Humans; Middle Aged; Myocardial Infarction; Necrosis; Nicorandil; Potassium Channels; Reperfusion Injury; Research Design; Sample Size; Troponin T; Ventricular Function, Left

2004
Nicorandil attenuates NF-kappaB activation, adhesion molecule expression, and cytokine production in patients with coronary artery bypass surgery.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:2

    Topics: Antihypertensive Agents; Aorta; Brain; CD18 Antigens; Cell Adhesion; Coronary Artery Bypass; Creatine Kinase; Cytokines; Flow Cytometry; Granulocytes; Hemodynamics; Humans; Interleukin-6; Interleukin-8; Lipopolysaccharides; Monocytes; Muscles; Myocardium; NF-kappa B; Nicorandil; Potassium Channels; Reperfusion Injury; Time Factors; Troponin T

2005
Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials.
    Lancet (London, England), 2007, Oct-27, Volume: 370, Issue:9597

    Topics: Atrial Natriuretic Factor; Creatine Kinase; Female; Humans; Infusions, Intravenous; Japan; Male; Middle Aged; Myocardial Infarction; Nicorandil; Reperfusion Injury; Vasodilator Agents

2007

Other Studies

22 other study(ies) available for nicorandil and Injury, Ischemia-Reperfusion

ArticleYear
Subnormothermic isolated organ perfusion with Nicorandil increased cold ischemic tolerance of liver in experimental model.
    Clinical hemorheology and microcirculation, 2022, Volume: 81, Issue:1

    Topics: Animals; Cold Temperature; Inflammation; Ischemia; Liver; Male; Microcirculation; Models, Theoretical; Nicorandil; Organ Preservation; Perfusion; Rats; Rats, Wistar; Reperfusion Injury

2022
Nicorandil, a K
    Lung, 2020, Volume: 198, Issue:2

    Topics: Animals; Capillary Permeability; Cyclic GMP; KATP Channels; Lung; Lung Injury; Male; Membrane Transport Modulators; Nicorandil; Perfusion; Pulmonary Circulation; Pulmonary Edema; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Soluble Guanylyl Cyclase; Vascular Resistance

2020
Ameliorative effect of nicorandil in ovarian ischemia-reperfusion-induced injury in rats: role of potassium channel.
    Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Disease Models, Animal; Female; KATP Channels; Nicorandil; Ovarian Diseases; Ovary; Oxidative Stress; Rats; Reperfusion Injury; Signal Transduction

2020
Effects of nicorandil on neurobehavioral function, BBB integrity, edema and stereological parameters of the brain in the sub-acute phase of stroke in a rat model.
    Journal of biosciences, 2020, Volume: 45

    Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Nicorandil; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke

2020
Optimizing Nicorandil for Spinal Cord Protection in a Murine Model of Complex Aortic Intervention.
    Seminars in thoracic and cardiovascular surgery, 2022,Spring, Volume: 34, Issue:1

    Topics: Animals; Disease Models, Animal; Humans; Ischemia; KATP Channels; Male; Mice; Mice, Inbred C57BL; Nicorandil; Reperfusion Injury; Spinal Cord Ischemia; Treatment Outcome

2022
Reactive Oxygen Species Mediate Nicorandil-induced Metabolic Tolerance to Spinal Cord Injury.
    The Annals of thoracic surgery, 2021, Volume: 112, Issue:1

    Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Nicorandil; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Spinal Cord Injuries; Spinal Cord Ischemia

2021
Pharmacologic prophylactic treatment for perioperative protection of skeletal muscle from ischemia-reperfusion injury in reconstructive surgery.
    Plastic and reconstructive surgery, 2013, Volume: 131, Issue:3

    Topics: Animals; Muscle, Skeletal; Nicorandil; Plastic Surgery Procedures; Postoperative Complications; Reperfusion Injury; Surgical Flaps; Swine; Vasodilator Agents

2013
Nicorandil protects against ischaemia-reperfusion injury in newborn rat kidney.
    Pharmacology, 2013, Volume: 92, Issue:5-6

    Topics: Acute Kidney Injury; Animals; Animals, Newborn; Apoptosis; Cytokines; Disease Models, Animal; Inflammation; KATP Channels; Male; NF-kappa B; Nicorandil; Phosphatidylinositol 3-Kinases; Potassium Channels, Inwardly Rectifying; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents

2013
Nicorandil Protects the Heart from Ischemia/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K/Akt Signaling Pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:6

    Topics: Animals; Apoptosis; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Heart; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction

2015
Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow.
    Journal of the neurological sciences, 2015, Oct-15, Volume: 357, Issue:1-2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Chromones; Circulatory Arrest, Deep Hypothermia Induced; Disease Models, Animal; Down-Regulation; Mice; Morpholines; Neuroprotective Agents; Nicorandil; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reperfusion Injury; Signal Transduction; Up-Regulation

2015
Cardioprotective effect of nicorandil against myocardial injury following cardiac arrest in swine.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:8

    Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Heart Arrest; Injections, Intravenous; Male; Nicorandil; Reperfusion Injury; Swine; Ventricular Fibrillation

2017
The effect of nicorandil on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model.
    The Journal of surgical research, 2011, May-01, Volume: 167, Issue:1

    Topics: Animals; Aspartate Aminotransferases; Glyburide; KATP Channels; L-Lactate Dehydrogenase; Liver; Models, Animal; Nicorandil; Regional Blood Flow; Reperfusion Injury; Swine; Vasodilator Agents

2011
Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney.
    British journal of pharmacology, 2011, Volume: 163, Issue:2

    Topics: Animals; Cromakalim; DNA Damage; Ion Channel Gating; KATP Channels; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Lipid Peroxidation; Male; Nicorandil; Oxidative Stress; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2011
The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:8

    Topics: Animals; Disease Models, Animal; Dogs; Female; Glyburide; Intestine, Small; KATP Channels; Male; Mesenteric Arteries; Nicorandil; Reperfusion Injury; Vasodilator Agents

2011
Nicorandil and leukocyte activation.
    Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:5

    Topics: Animals; Calcium; Cells, Cultured; Heart; Humans; Ischemia; Leukocytes; Microcirculation; Nicorandil; Nitric Oxide; Potassium Channels; Rats; Rats, Wistar; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction

2002
Nicorandil preserves the function of the mitochondrial phosphorylative and oxidative system in an animal model of global ischemia-reperfusion.
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 2007, Volume: 26, Issue:5

    Topics: Animals; Mitochondria; Nicorandil; Oxidative Phosphorylation; Potassium Channels; Rats; Rats, Wistar; Reperfusion Injury

2007
Comparative study on the effects of intracoronary nicorandil and nitroglycerin in ischaemic, reperfused porcine hearts.
    European heart journal, 1995, Volume: 16, Issue:5

    Topics: Animals; Female; Hemodynamics; Injections, Intra-Arterial; Male; Niacinamide; Nicorandil; Nitroglycerin; Oxygen Consumption; Potassium Channels; Reperfusion Injury; Swine; Vasodilator Agents

1995
Antioxidative action of the nitrovasodilator nicorandil: inhibition of oxidative activation of liver microsomal glutathione S-transferase and lipid peroxidation.
    Japanese journal of pharmacology, 1994, Volume: 65, Issue:3

    Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione Transferase; Isosorbide Dinitrate; Lipid Peroxidation; Male; Microsomes, Liver; Niacinamide; Nicorandil; Nitroglycerin; Oxidation-Reduction; Propanolamines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Sympathetic Nervous System; Vasodilator Agents

1994
Nicorandil, a potent adenosine triphosphate-sensitive potassium-channel opener, ameliorates lung allograft reperfusion injury.
    The Journal of thoracic and cardiovascular surgery, 1996, Volume: 112, Issue:5

    Topics: Animals; Dogs; Hemodynamics; Lung; Lung Transplantation; Niacinamide; Nicorandil; Potassium Channels; Reperfusion Injury; Transplantation, Homologous

1996
Effects of nicorandil administration on survival rate and arrhythmias during reperfusion in anesthetized rabbits.
    Pharmacology, 2001, Volume: 63, Issue:3

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Myocardial Ischemia; Nicorandil; Rabbits; Reperfusion Injury; Survival Rate; Time Factors; Tolbutamide

2001
Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.
    Naunyn-Schmiedeberg's archives of pharmacology, 2001, Volume: 364, Issue:5

    Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Gas Analysis; Coronary Disease; Decanoic Acids; Dihydropyridines; Drug Combinations; Hemodynamics; Hydroxy Acids; Male; Myocardial Ischemia; Nicorandil; Potassium Channels; Rabbits; Reperfusion Injury; Survival Rate

2001
Acceleration of recovery of mitochondrial function after coronary reperfusion by various coronary dilating drugs in canine hearts.
    Journal of cardiovascular pharmacology, 1989, Volume: 13, Issue:2

    Topics: Animals; Blood Pressure; Coronary Circulation; Dilazep; Diltiazem; Dogs; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Mitochondria, Heart; Monoamine Oxidase Inhibitors; Niacinamide; Nicorandil; Reperfusion Injury; Vasodilator Agents

1989