nicorandil has been researched along with Disease Models, Animal in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.70) | 18.7374 |
| 1990's | 7 (9.46) | 18.2507 |
| 2000's | 25 (33.78) | 29.6817 |
| 2010's | 32 (43.24) | 24.3611 |
| 2020's | 8 (10.81) | 2.80 |
| Authors | Studies |
|---|---|
| Almeida, MO; Araujo, DP; César, IC; Coelho, MM; de Fátima, A; Dutra, MM; Godin, AM; Machado, RR; Menezes, RR; Oliveira, FC; Pianetti, GA; Santos, DA; Santos, JR | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Liang, D; Qiang, J; Sun, Q; Wang, W; Xie, T; Yang, L; Zhao, J | 1 |
| Abdel-Gaber, SA; Abdel-Hafez, SMN; Abdelzaher, WY; Atta, M | 1 |
| Bigdeli, MR; Namavar, MR; Owjfard, M; Safari, A | 1 |
| Aftab, M; Cheng, L; Cleveland, JC; Fullerton, DA; Ghincea, CV; Ikeno, Y; Meng, X; Reece, TB; Roda, GF; Weyant, MJ | 2 |
| Afzal, MZ; Beatka, MJ; Haberman, M; Lam, NT; Lawlor, MW; Strande, JL; Sullivan, RT | 1 |
| Bigdeli, MR; Borhani-Haghighi, A; Namavar, MR; Owjfard, M; Safari, A; Taghadosi, Z; Zarifkar, A | 1 |
| Abdelkafy, AML; Gaafar, AGA; Messiha, BAS | 1 |
| Agha, AM; Ahmed, LA; Mohamed, YS; Salem, HA | 1 |
| El-Kashef, DH | 2 |
| Choi, J; Chung, HY; Jeong, W; Kim, J; Kim, R; Lee, HW; Park, SW | 1 |
| Kong, B; Lv, X; Qin, Z; Su, Q; Sun, Y; Ye, Z | 1 |
| Li, X; Ling, M; Liu, C; Wang, Z; Xing, Y; Zhang, H; Zhang, M | 1 |
| Kapoor, S | 1 |
| Araújo, DP; Bastos, LF; César, IC; Coelho, MM; de Fátima, Â; Dutra, MM; Ferreira, WC; Godin, AM; Machado, RR; Menezes, RR; Nascimento, EB; Pianetti, GA; Seniuk, JG; Soares, DG | 1 |
| Tian, ZL; Yao, L; Zhang, AQ; Zhang, YJ; Zhao, XX | 1 |
| Higaki, M; Johnson, RJ; Nagura, M; Nakagawa, T; Shima, T; Shiraishi, T; Tamura, Y; Taniguchi, K; Uchida, S; Ueda, S | 1 |
| Gu, J; Guo, Z; Hao, YY; Sun, JM; Wang, AL; Wang, CM; Xie, YJ | 1 |
| Gupta, S; Sharma, B; Singh, P | 2 |
| Fukayama, T; Fukushima, R; Goya, S; Nakata, TM; Tanaka, R; Yoshiyuki, R | 1 |
| Aizawa, K; Endo, K; Fukuyama, N; Higashijima, N; Hirano, K; Ishida, H; Ishizuka, N; Serizawa, K; Takahari, Y; Yogo, K | 1 |
| Fan, C; Feng, Y; Hu, L; Mo, X; Wen, Z; Yang, L; Yin, KJ; Yu, D; Zhang, W | 1 |
| Araújo, DP; Augusto, PS; Brito, AM; Coelho, MM; de Fátima, Â; Dutra, MM; Godin, AM; Machado, RR; Melo, IS; Nascimento Júnior, EB; Rodrigues, FF | 1 |
| Afzal, MZ; Childers, MK; Ebert, AD; Gastonguay, C; Ge, ZD; Guan, X; Mack, DL; McGivern, JV; Reiter, M; Strande, JL | 1 |
| Chen, JS; Chen, YD; Li, B; Ma, Q; Tian, F; Zhang, Y; Zhang, YQ; Zhou, Y | 1 |
| Amirthalingam, SK; Gopalakrishnan, S; Kurian, GA; Murali, J; Ravindran, S | 1 |
| Chen, JB; Hou, ZQ; Hu, HR; Ji, XF; Liang, LN; Shang, DY; Zhong, X; Zhou, Y; Zhu, FF | 1 |
| Eremenko, LT; Garanin, VA; Kosilko, VP; Nesterenko, DA; Pisarenko, OI; Serebriakova, LI; Tskitishvili, OV | 1 |
| Abdollahi, M; Hosseini-Tabatabaei, A | 1 |
| Horie, S; Ishizuka, N; Otsuka, H; Saito, K; Sudo, H; Yogo, K | 1 |
| Grace, AA; Hothi, SS; Huang, CL; Killeen, MJ; Thomas, G | 1 |
| Hirose, M; Horiuchi-Hirose, M; Nakada, T; Tsujino, N; Yamada, M; Yano, S | 1 |
| Hirata, M; Ishizuka, N; Kanada, H; Kataoka, M; Moriguchi, Y; Serizawa, K; Sudo, H; Tashiro, Y; Yogo, K; Yorozu, K | 1 |
| Asbach, S; Biermann, J; Bode, C; Brunner, M; Koren, G; Odening, KE; Peng, X; Wu, K; Zehender, M | 1 |
| Araki, S; Izumiya, Y; Kaikita, K; Kojima, S; Matsubara, J; Nagayoshi, Y; Ogawa, H; Sakamoto, K; Sugiyama, S; Tsujita, K; Usuku, H | 1 |
| Hayashi, Y; Iwasaki, M; Kamibayashi, T; Mashimo, T; Yamanaka, H | 1 |
| Arakawa, K; Matsumoto, K; Oshima, K; Sato, H; Suto, Y; Takeyoshi, I; Yamazaki, H | 1 |
| Babelova, A; Brandes, RP; Buerkl, J; Hofstetter, C; Kirschning, T; Mieth, A; Neofitidou, S; Revermann, M; Schermuly, RT; Schloss, M; Schröder, K | 1 |
| Johnson, RJ; Kitagawa, W; Klawitter, J; Lanaspa, MA; Makino, H; Mathieson, PW; Miyazaki, M; Nakagawa, T; Rivard, CJ; Saleem, MA; Schreiner, GF; Tanabe, K | 1 |
| Dimitriadis, F; Inoue, S; Kinoshita, Y; Ohmasa, F; Saito, M; Satoh, K; Tsounapi, P | 1 |
| Chang, PC; Chou, CC; Chu, Y; Lee, HL; Wen, MS; Wo, HT; Wu, D; Yeh, SJ | 1 |
| Aizawa, Y; Chinushi, M; Chinushi, Y; Hosaka, Y; Kasai, H; Tagawa, M; Washizuka, T | 1 |
| Chujo, M; Higgins, CB; Krombach, GA; Lund, GK; Saeed, M; Watzinger, N; Wendland, MF | 1 |
| Genda, S; Ichikawa, Y; Miki, T; Miura, T; Shimamoto, K | 1 |
| Hirai, M; Iino, S; Kondo, T; Takeshita, K; Tanaka, T | 1 |
| Mizuno, T; Sakamoto, T; Sunamori, M; Tanaka, H; Watanabe, M | 1 |
| Chan, P; Cheng, JT; Liu, IM; Tzeng, TF; Wong, KL; Yang, TL | 1 |
| Cokkinos, P; Iliodromitis, EK; Kremastinos, DT; Steliou, I; Vrettou, AR; Zoga, A | 1 |
| Das, B; Sarkar, C | 1 |
| Devaki, T; Ebenezar, KK; Sathish, V | 1 |
| Li, C; Liu, K; Liu, Y; Shi, G; Wang, H; Yang, Z | 1 |
| Bin, JP; Cha, DG; Feng, L; Huang, XB; Ma, J; Qiu, J | 1 |
| Chen, JL; Chen, ZJ; Gao, RL; Jing, ZC; Meng, L; Tian, Y; Wu, YJ; Yang, WX; Yang, YJ; You, SJ; Zhao, JL | 1 |
| Higuchi, S; Itoh, T; Murayama, J; Natsuaki, M; Okazaki, Y; Takarabe, K | 1 |
| Chang, NC; Lee, TM; Lin, MS | 1 |
| Gao, RL; Pei, WD; Sun, YH; Yang, YJ; Zhai, M; Zhang, YH; Zhao, JL | 1 |
| Hirose, M; Imamura, H; Nakada, T; Tsujino, N; Yamada, M; Yano, S | 1 |
| Gross, GJ; Hardman, HF; Lamping, KA; Warltier, DC | 1 |
| Maruyama, M; Satoh, K; Taira, N; Yamashita, S | 1 |
| Fukata, Y; Fukushima, H; Harada, K; Kaneta, S; Miwa, A; Ogawa, N | 1 |
| Chujo, M; Critz, SD; Downey, JM; Liu, GS | 1 |
| Baxter, GF; Imagawa, J; Yellon, DM | 1 |
| Koyama, T; Matsuzaki, T; Nakasone, J; Noguchi, K; Ojiri, Y; Sakanashi, M | 1 |
| Ito, S; Nishikado, A; Sakabe, K; Shinohara, H; Wakatsuki, T | 1 |
| Marbán, E; O'Rourke, B; Sasaki, N; Sato, T | 1 |
| Kitano, M; Matsui, K; Ohashi, N; Satoh, K; Yamada, K; Yamamoto, S | 1 |
| Goswami, SG; Patel, HM; Santani, DD | 1 |
| Kamijo, T; Kido, H; Miwa, A; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| Hamilton, TC; Longman, SD | 1 |
1 review(s) available for nicorandil and Disease Models, Animal
| Article | Year |
|---|---|
Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular System; Central Nervous System; Clinical Trials as Topic; Cromakalim; Disease Models, Animal; Guanidines; Humans; Muscle, Smooth, Vascular; Muscles; Neurons; Niacinamide; Nicorandil; Pancreas; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
1 trial(s) available for nicorandil and Disease Models, Animal
| Article | Year |
|---|---|
Levosimendan attenuates pulmonary vascular remodeling.
Topics: Airway Remodeling; Animals; Cardiotonic Agents; Disease Models, Animal; Germany; Glyburide; Hydrazones; Hypertension, Pulmonary; Hypoglycemic Agents; Myocardial Contraction; Nicorandil; Potassium Channels; Pulmonary Circulation; Pyridazines; Rats; Rats, Sprague-Dawley; Simendan; Vasodilator Agents | 2011 |
72 other study(ies) available for nicorandil and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Half-Life; Isomerism; Mice; Nicorandil; Pain | 2014 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Nicorandil Exerts Anticonvulsant Effects in Pentylenetetrazol-Induced Seizures and Maximal-Electroshock-Induced Seizures by Downregulating Excitability in Hippocampal Pyramidal Neurons.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Hippocampus; Nicorandil; Nitrates; Pentylenetetrazole; Pyramidal Cells; Seizures | 2023 |
Ameliorative effect of nicorandil in ovarian ischemia-reperfusion-induced injury in rats: role of potassium channel.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Disease Models, Animal; Female; KATP Channels; Nicorandil; Ovarian Diseases; Ovary; Oxidative Stress; Rats; Reperfusion Injury; Signal Transduction | 2020 |
Effects of nicorandil on neurobehavioral function, BBB integrity, edema and stereological parameters of the brain in the sub-acute phase of stroke in a rat model.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Nicorandil; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke | 2020 |
Optimizing Nicorandil for Spinal Cord Protection in a Murine Model of Complex Aortic Intervention.
Topics: Animals; Disease Models, Animal; Humans; Ischemia; KATP Channels; Male; Mice; Mice, Inbred C57BL; Nicorandil; Reperfusion Injury; Spinal Cord Ischemia; Treatment Outcome | 2022 |
Reactive Oxygen Species Mediate Nicorandil-induced Metabolic Tolerance to Spinal Cord Injury.
Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Nicorandil; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Spinal Cord Injuries; Spinal Cord Ischemia | 2021 |
Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Female; Fibrosis; Isoproterenol; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Myocytes, Cardiac; NADPH Oxidases; Nicorandil; Reactive Oxygen Species; Stroke Volume; Superoxide Dismutase; Ventricular Function, Left; Xanthine Oxidase | 2021 |
Effect of nicorandil on the spatial arrangement of primary motor cortical neurons in the sub-acute phase of stroke in a rat model.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Motor Cortex; Motor Neurons; Nicorandil; Rats; Rats, Sprague-Dawley; Stroke; Treatment Outcome; Vasodilator Agents | 2021 |
Nicorandil and theophylline can protect experimental rats against complete Freund's adjuvant-induced rheumatoid arthritis through modulation of JAK/STAT/RANKL signaling pathway.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Female; Freund's Adjuvant; Janus Kinases; Joints; Nicorandil; RANK Ligand; Rats; Rats, Wistar; Signal Transduction; STAT Transcription Factors; Theophylline | 2018 |
Role of nitric oxide and KATP channel in the protective effect mediated by nicorandil in bile duct ligation-induced liver fibrosis in rats.
Topics: Animals; Biomarkers; Cholestasis; Disease Models, Animal; KATP Channels; Liver Cirrhosis; Liver Function Tests; Male; Nicorandil; Nitric Oxide; Oxidative Stress; Protective Agents; Rats, Wistar | 2018 |
Nicorandil alleviates ovalbumin-induced airway inflammation in a mouse model of asthma.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glutathione; Interleukin-13; Leukocyte Count; Lung; Male; Malondialdehyde; Mice; NF-kappa B; Nicorandil; Nitric Oxide; Ovalbumin; Superoxide Dismutase | 2018 |
Nicorandil reduces burn wound progression by enhancing skin blood flow.
Topics: Animals; Apoptosis; Burns; Disease Models, Animal; In Situ Nick-End Labeling; Laser-Doppler Flowmetry; Male; Nicorandil; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Skin; Treatment Outcome; Vasodilator Agents; Wound Healing | 2018 |
Role of TLR4/MyD88/NF-κB signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Coronary Stenosis; Cytoprotection; Disease Models, Animal; Embolism; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Male; Microspheres; Myeloid Differentiation Factor 88; Myocardial Infarction; Myocarditis; Myocytes, Cardiac; NF-kappa B; Nicorandil; Rats, Sprague-Dawley; Signal Transduction; Stroke Volume; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left; Ventricular Function, Left | 2018 |
Nicorandil ameliorates pulmonary inflammation and fibrosis in a rat model of silicosis.
Topics: Animals; Collagen; Disease Models, Animal; Male; Nicorandil; Nitric Oxide Synthase Type II; Pneumonia; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Silicosis; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2018 |
Myocardial Protective Effects of Nicorandil on Rats with Type 2 Diabetic Cardiomyopathy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Heart; Male; Malondialdehyde; Myocardium; Nicorandil; Rats; Rats, Wistar; Superoxide Dismutase | 2018 |
Nicorandil and its associated gastrointestinal side effects.
Topics: Animals; Disease Models, Animal; Humans; Myocardial Infarction; Nicorandil; Ventricular Fibrillation | 2013 |
Activity of nicorandil, a nicotinamide derivative with a nitrate group, in the experimental model of pain induced by formaldehyde in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Glyburide; Male; Mice; Nicorandil; Oxadiazoles; Pain | 2013 |
Nicorandil protects against ischaemia-reperfusion injury in newborn rat kidney.
Topics: Acute Kidney Injury; Animals; Animals, Newborn; Apoptosis; Cytokines; Disease Models, Animal; Inflammation; KATP Channels; Male; NF-kappa B; Nicorandil; Phosphatidylinositol 3-Kinases; Potassium Channels, Inwardly Rectifying; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents | 2013 |
Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Blood Pressure; Cell Line; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enalapril; KATP Channels; Kidney; Male; Mice; Nephrectomy; Nicorandil; Oxidative Stress; Podocytes; Potassium Channel Blockers; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Sirtuin 3; Sulfonylurea Receptors; Superoxide Dismutase; Time Factors | 2014 |
Reduction of isoproterenol-induced cardiac hypertrophy and modulation of myocardial connexin43 by a KATP channel agonist.
Topics: Animals; Cardiomegaly; Connexin 43; Disease Models, Animal; Gene Expression; Heart Ventricles; Immunohistochemistry; Isoproterenol; KATP Channels; Male; Myocardium; Natriuretic Peptide, Brain; Nicorandil; Rats; RNA, Messenger | 2015 |
Melatonin receptor and KATP channel modulation in experimental vascular dementia.
Topics: Acetamides; Animals; Arterial Pressure; Brain; Dementia, Vascular; Disease Models, Animal; Hypertension, Renovascular; KATP Channels; Male; Maze Learning; Neuroprotective Agents; Nicorandil; Nootropic Agents; Oxidative Stress; Random Allocation; Rats, Wistar; Receptors, Melatonin; Spatial Memory | 2015 |
Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nicorandil; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyridazines; Rats, Wistar; Recovery of Function; Severity of Illness Index; Sildenafil Citrate; Vasodilator Agents; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
Nicorandil prevents sirolimus-induced production of reactive oxygen species, endothelial dysfunction, and thrombus formation.
Topics: Animals; Anti-Arrhythmia Agents; Arteries; Cell Survival; Cells, Cultured; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Humans; Male; Mice, Inbred ICR; NADPH Oxidases; Nicorandil; Reactive Oxygen Species; Sirolimus; Superoxide Dismutase; Testis; Thrombosis; Up-Regulation | 2015 |
Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Chromones; Circulatory Arrest, Deep Hypothermia Induced; Disease Models, Animal; Down-Regulation; Mice; Morpholines; Neuroprotective Agents; Nicorandil; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reperfusion Injury; Signal Transduction; Up-Regulation | 2015 |
Opioid pathways activation mediates the activity of nicorandil in experimental models of nociceptive and inflammatory pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Mice; Nicorandil; Nociceptive Pain; Signal Transduction | 2015 |
Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy.
Topics: Animals; Cardiomyopathies; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Induced Pluripotent Stem Cells; KATP Channels; Male; Mice, Inbred mdx; Mitochondria, Heart; Muscular Dystrophy, Animal; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nicorandil; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Reactive Oxygen Species; Recovery of Function; Signal Transduction; Ventricular Function, Left; Xanthine Oxidase | 2016 |
Neuroprotective Effects of Nicorandil in Chronic Cerebral Hypoperfusion-Induced Vascular Dementia.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Brain Ischemia; Catalase; Cerebrovascular Circulation; Cognition; Dementia, Vascular; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; GPI-Linked Proteins; Inflammation Mediators; KATP Channels; Male; Maze Learning; Mice; Neuroprotective Agents; Nicorandil; Oxidative Stress; Peroxidase; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors | 2016 |
Delayed reendothelialization with rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries.
Topics: Animals; Apoptosis; Carotid Artery Injuries; Cell Movement; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Nicorandil; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Sirolimus; Xanthine Oxidase | 2016 |
Vascular calcification abrogates the nicorandil mediated cardio-protection in ischemia reperfusion injury of rat heart.
Topics: Animals; Biomarkers; Cardiovascular Agents; Cytoprotection; Disease Models, Animal; Energy Metabolism; Hemodynamics; Isolated Heart Preparation; Lipid Peroxidation; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nicorandil; Oxidative Stress; Potassium Channels; Rats, Wistar; Vascular Calcification | 2017 |
Cardioprotective effect of nicorandil against myocardial injury following cardiac arrest in swine.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Heart Arrest; Injections, Intravenous; Male; Nicorandil; Reperfusion Injury; Swine; Ventricular Fibrillation | 2017 |
[The study of vasodilative and antiischemic function of nicorandil in regional ischemia and reperfusion of rat heart in vivo].
Topics: Animals; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Heart Rate; Male; Myocardial Reperfusion Injury; Nicorandil; Nitroglycerin; Rats; Rats, Wistar; Treatment Outcome; Vasodilation; Vasodilator Agents | 2008 |
Potassium channel openers and improvement of toxic stress: do they have role in the management of inflammatory bowel disease?
Topics: Animals; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Nicorandil; Nitric Oxide; Oxidative Stress; Potassium Channels | 2008 |
Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Heart Rate; Ion Channel Gating; Nicorandil; Nitric Oxide Donors; Potassium Channels; Rats; Rats, Sprague-Dawley; Urinary Bladder Neck Obstruction; Urination Disorders | 2008 |
Empirical correlation of triggered activity and spatial and temporal re-entrant substrates with arrhythmogenicity in a murine model for Jervell and Lange-Nielsen syndrome.
Topics: Action Potentials; Algorithms; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Electric Stimulation; Endocardium; Female; Heart; Jervell-Lange Nielsen Syndrome; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Nicorandil; Perfusion; Pericardium; Potassium Channels, Voltage-Gated; Sex Characteristics; Tachycardia, Ventricular; Time Factors; Ventricular Dysfunction, Left | 2009 |
Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Topics: Action Potentials; Animals; Coronary Vessels; Disease Models, Animal; Dogs; Heart Atria; Heart Conduction System; Myocardial Ischemia; Nicorandil; Perfusion | 2011 |
Nicorandil improves glomerular injury in rats with mesangioproliferative glomerulonephritis via inhibition of proproliferative and profibrotic growth factors.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Cell Proliferation; Collagen Type I; Disease Models, Animal; Fibronectins; Glomerulonephritis, Membranoproliferative; Isoantibodies; Kidney Glomerulus; Male; Nicorandil; Organ Size; Platelet-Derived Growth Factor; Proteinuria; Rats; Rats, Inbred F344; Transforming Growth Factor beta | 2009 |
Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Disease Models, Animal; Female; Heart; Humans; In Vitro Techniques; Male; Nicorandil; Perfusion; Rabbits; Romano-Ward Syndrome; Time Factors | 2011 |
Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris.
Topics: Administration, Oral; Aged; Aged, 80 and over; Angina Pectoris; Animals; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Cardiovascular Agents; Cells, Cultured; Chi-Square Distribution; Coronary Artery Disease; Cytokines; Disease Models, Animal; Drug Administration Schedule; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endothelial Cells; Fibrosis; Humans; Inflammation Mediators; Japan; Lipids; Logistic Models; Macrophages; Male; Mice; Mice, Knockout; Middle Aged; Molecular Chaperones; Necrosis; Nicorandil; Odds Ratio; Retrospective Studies; Time Factors; Treatment Outcome; Ultrasonography, Interventional | 2011 |
Nicorandil preserves myocardial function following brain death in rats by mitochondrial adenosine triphosphate-sensitive potassium channel-dependent mechanism.
Topics: Animals; Blood Pressure; Brain Death; Cardiac Output; Cardiotonic Agents; Decanoic Acids; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; Heart Rate; Hydroxy Acids; Male; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley | 2011 |
The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model.
Topics: Animals; Disease Models, Animal; Dogs; Female; Glyburide; Intestine, Small; KATP Channels; Male; Mesenteric Arteries; Nicorandil; Reperfusion Injury; Vasodilator Agents | 2011 |
Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse.
Topics: Animals; Antioxidants; Apoptosis; Blood Pressure; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicorandil; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxidative Stress; Podocytes; Reactive Oxygen Species; Severity of Illness Index; Streptozocin | 2012 |
Nicorandil ameliorates hypertension-related bladder dysfunction in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hypertension; KATP Channels; Male; Nerve Growth Factor; Nicorandil; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred SHR; Rats, Wistar; Real-Time Polymerase Chain Reaction; Regional Blood Flow; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Urinary Bladder; Urinary Bladder, Overactive; Urination; Urodynamics | 2012 |
Blunted proarrhythmic effect of nicorandil in a Langendorff-perfused phase-2 myocardial infarction rabbit model.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Humans; Myocardial Infarction; Nicorandil; Perfusion; Rabbits; Treatment Outcome; Ventricular Fibrillation | 2013 |
Triggers of ventricular tachyarrhythmias and therapeutic effects of nicorandil in canine models of LQT2 and LQT3 syndromes.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Bradycardia; Disease Models, Animal; Dogs; Electrocardiography; Heart Block; Heart Conduction System; Infusions, Intravenous; Long QT Syndrome; Models, Cardiovascular; Nicorandil; Tachycardia; Treatment Outcome | 2002 |
Left ventricular remodeling after infarction: sequential MR imaging with oral nicorandil therapy in rat model.
Topics: Administration, Oral; Animals; Cardiac Volume; Disease Models, Animal; Female; Heart Ventricles; Magnetic Resonance Imaging; Mesoporphyrins; Myocardial Infarction; Nicorandil; Rats; Rats, Sprague-Dawley; Stroke Volume; Vasodilator Agents; Ventricular Remodeling | 2002 |
K(ATP) channel opening is an endogenous mechanism of protection against the no-reflow phenomenon but its function is compromised by hypercholesterolemia.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Chronic Disease; Coronary Circulation; Disease Models, Animal; Glyburide; Hemodynamics; Hypercholesterolemia; Male; Myocardial Infarction; Nicorandil; Nitric Oxide Synthase; omega-N-Methylarginine; Potassium Channel Blockers; Potassium Channels; Rabbits; Vasodilator Agents | 2002 |
The effects of vasodilators on the relaxation of guinea-pig aorta during acute recoil.
Topics: Adrenergic alpha-Antagonists; Amlodipine; Angioplasty, Balloon, Coronary; Animals; Aorta, Thoracic; Disease Models, Animal; Female; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Isosorbide Dinitrate; Muscle Relaxation; Muscle, Smooth, Vascular; Nicorandil; Nifedipine; Phentolamine; Platelet Aggregation Inhibitors; Postoperative Complications; Succinates; Vasodilator Agents | 2002 |
2-Nicotinamidoethyl nitrale (2-NN) protects myocardium in ischemia and reperfusion via the protein kinase C pathway.
Topics: Animals; Coronary Circulation; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Heart Function Tests; Hemodynamics; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Naphthalenes; Nicorandil; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity | 2002 |
Antihyperglycemic action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Glucose; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Gene Expression; Glucose Tolerance Test; Glucose Transporter Type 4; Hyperglycemia; Liver; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Nicorandil; Nifedipine; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; RNA, Messenger; Saralasin; Tetrazoles; Valine; Valsartan | 2003 |
Oral nicorandil recaptures the waned protection from preconditioning in vivo.
Topics: Administration, Oral; Animals; Blood Pressure; Decanoic Acids; Disease Models, Animal; Drug Combinations; Heart Rate; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion; Nicorandil; Rabbits; Sodium-Potassium-Exchanging ATPase; Time Factors; Ventricular Fibrillation | 2003 |
Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Cromakalim; Decanoic Acids; Disease Models, Animal; Glutathione; Heart Rate; Hydroxy Acids; Male; Malondialdehyde; Membrane Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Oxidative Stress; Potassium Channels; Rabbits; Sarcolemma; Sulfonamides; Superoxide Dismutase; Survival Rate; Thiourea | 2003 |
Synergistic effect of nicorandil and amlodipine on lysosomal hydrolases during experimental myocardial infarction in rats.
Topics: Administration, Oral; Amlodipine; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Hydrolases; Injections, Intraperitoneal; Lysosomes; Male; Myocardial Infarction; Myocardium; Nicorandil; Rats; Rats, Wistar; Subcellular Fractions | 2003 |
Electrophysiologic effects of nicorandil on the guinea pig long QT1 syndrome model.
Topics: Action Potentials; Animals; Chromans; Disease Models, Animal; Electrocardiography; Guinea Pigs; In Vitro Techniques; Long QT Syndrome; Nicorandil; Potassium Channel Blockers; Sulfonamides; Vasodilator Agents | 2004 |
[Cardioprotective effects of K(ATP) channel opener nicorandil during ischemia/ reperfusion in dogs].
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dogs; Female; Ischemic Preconditioning, Myocardial; KATP Channels; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Nicorandil; Random Allocation; Time Factors; Vasodilator Agents | 2005 |
[Neuron-protective effect of ischemic preconditioning in a rabbit reperfusion model following spinal ischemia].
Topics: Animals; Disease Models, Animal; Glyburide; Ischemic Preconditioning; Male; Neurons; Nicorandil; Potassium Channels; Rabbits; Spinal Cord; Vasodilator Agents | 2005 |
[Beneficial effects of nicorandil on myocardial no-reflow state in a mini-swine model of acute myocardial infarction and reperfusion].
Topics: Animals; Coronary Vessels; Disease Models, Animal; Female; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Nicorandil; Random Allocation; Regional Blood Flow; Swine; Swine, Miniature | 2005 |
Nicorandil attenuates reperfusion injury after long cardioplegic arrest.
Topics: Animals; Cardiotonic Agents; Coronary Vessels; Disease Models, Animal; Endothelium, Vascular; Extracorporeal Circulation; Heart Arrest, Induced; Leukocytes; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Nicorandil; Peroxidase; Rabbits; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2007 |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.
Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GAP-43 Protein; Glyburide; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; KATP Channels; Ligation; Male; Myocardial Infarction; Myocardium; Neurofilament Proteins; Nicorandil; Norepinephrine; Pinacidil; Polymerase Chain Reaction; Potassium Channel Blockers; Pravastatin; Rats; Rats, Wistar; RNA, Messenger; Sympathetic Nervous System; Tachycardia, Ventricular; Time Factors; Tyrosine 3-Monooxygenase; Ventricular Fibrillation; Ventricular Remodeling | 2007 |
Intravenous nicorandil preserves endothelial junctions by decreasing endothelin-1 via activation of ATP-sensitive K+ channel.
Topics: Animals; Antigens, CD; Cadherins; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Endothelin-1; Glyburide; Injections, Intravenous; Intercellular Junctions; KATP Channels; Ligation; Myocardial Infarction; Myocardium; Nicorandil; No-Reflow Phenomenon; Potassium Channel Blockers; Research Design; Swine; Swine, Miniature; Vasodilator Agents | 2007 |
Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzamides; Disease Models, Animal; Dogs; Drug Antagonism; Electric Stimulation; Heart Ventricles; Male; Myocardial Ischemia; Nicorandil; Organ Culture Techniques; Perfusion; Spectrometry, Fluorescence; Tachycardia; Ventricular Dysfunction, Left | 2008 |
Effects of nicorandil, a new antianginal agent, and nifedipine on collateral blood flow in a chronic coronary occlusion model.
Topics: Animals; Collateral Circulation; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Female; Hemodynamics; Male; Niacinamide; Nicorandil; Nifedipine; Vasodilator Agents | 1984 |
Nicorandil releases acetylcholine-induced sustained coronary arterial constriction in monkeys and baboons.
Topics: Acetylcholine; Animals; Coronary Circulation; Coronary Vasospasm; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Parenteral; Injections; Macaca; Macaca mulatta; Male; Niacinamide; Nicorandil; Papio | 1984 |
Effect of KRN2391, a novel vasodilator, on various experimental anginal models in rats.
Topics: Angina Pectoris; Animals; Disease Models, Animal; Electrocardiography; Injections, Intravenous; Isoproterenol; Male; Methacholine Chloride; Niacinamide; Nicorandil; Nifedipine; Pyridines; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes.
Topics: Adenosine Triphosphate; Animals; Cell Death; Disease Models, Animal; Electrophysiology; Female; Guanidines; Heart; Heart Ventricles; Male; Myocardial Ischemia; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Rabbits; Vasodilator Agents | 1997 |
Myocardial protection afforded by nicorandil and ischaemic preconditioning in a rabbit infarct model in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Niacinamide; Nicorandil; Rabbits | 1998 |
Beneficial hemodynamic effects of nicorandil in a canine model of acute congestive heart failure: comparison with nitroglycerin and cromakalim.
Topics: Acute Disease; Animals; Blood Pressure; Coronary Circulation; Cromakalim; Disease Models, Animal; Dogs; Female; Heart; Heart Failure; Heart Rate; Male; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Saponins; Vasodilator Agents | 1998 |
The effects of nicorandil on electrophysiological changes in acute myocardial ischemia and reperfusion.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Electrophysiology; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Ventricular Fibrillation | 1998 |
Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Flavoproteins; Fluorescence; Heart Ventricles; Mitochondria, Heart; Myocardial Ischemia; Nicorandil; Potassium Channels; Rabbits; Vasodilator Agents | 2000 |
Reduction of myocardial infarct size by SM-20550, a novel Na(+)/H(+) exchange inhibitor, in rabbits.
Topics: Amidines; Animals; Anti-Arrhythmia Agents; Blood Pressure; Creatine Kinase; Disease Models, Animal; Heart Rate; Indoles; Male; Myocardial Infarction; Nicorandil; Protective Agents; Rabbits; Sodium-Hydrogen Exchangers | 2000 |
Evaluation of the effects of nicorandil on experimentally induced gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Mucosa; Glyburide; Ligation; Male; Nicorandil; Proteins; Pylorus; Rats; Rats, Wistar; Stomach; Stomach Ulcer | 2001 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models, Animal; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Ion Channel Gating; Male; Methylene Blue; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |