nicorandil has been researched along with Cardiovascular Stroke in 150 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (2.67) | 18.7374 |
| 1990's | 24 (16.00) | 18.2507 |
| 2000's | 77 (51.33) | 29.6817 |
| 2010's | 29 (19.33) | 24.3611 |
| 2020's | 16 (10.67) | 2.80 |
| Authors | Studies |
|---|---|
| Deng, HF; Liu, K; Liu, MD; Ma, H; Wang, KK; Wang, N; Xiao, XZ; Zhu, LL; Zou, J | 1 |
| Amano, T; Kobara, M; Nakata, T; Toba, H | 1 |
| Li, P; Li, Y; Liang, X; Liao, W; Lin, Z; Liu, M; Xie, W | 1 |
| Chen, B; Lian, Z; Ren, J; Wan, Q; Wang, Y; Xia, Z; Yang, Y; Yao, X; Zhou, C | 1 |
| Ahn, J; Cha, KS; Choe, JC; Choi, JH; Kim, E; Kim, MS; Lee, HC; Lee, HW; Lee, JW; Oh, JH; Park, JH; Park, JS; Park, TS | 1 |
| Joo, WJ; Kawakami, K; Miyake, K; Seki, T; Takeuchi, M; Yoshida, S | 1 |
| Chen, L; Qi, G; Shi, L; Tian, W; Zhao, S | 1 |
| Li, J; Lu, A; Zhang, L | 1 |
| Gao, MD; Li, XW; Liu, Y; Liu, YY; Sun, GY; Xiao, JY; Zhang, EY | 1 |
| An, G; Hu, H; Hu, K; Su, G; Wang, X; Xu, Z; Zhang, J | 1 |
| Chen, X; Jiang, Y; Luo, J; Mo, S; Rong, J; Xiao, X; Yi, B | 1 |
| Bao, H; Cheng, X; Deng, H; Hu, X; Huang, X; Wan, K; Wang, D; Wang, H; Wu, Q; Xu, Z; Zhan, B; Zhang, Y | 1 |
| Chen, B; Cheng, A; Li, P; Sun, S; Xu, J; Zhou, J | 1 |
| Chen, Z; Li, L; Long, M; Qin, Z; Wang, F; Zheng, J | 1 |
| Dai, J; Hao, Z; He, B; Jiang, L; Qiu, X; Shen, L; Shi, H; Wang, X; Xu, K; Yang, X; Zhang, W; Zheng, X | 1 |
| Li, W; Zhang, G | 1 |
| Fan, Y; Feng, X; Li, T; Lv, J; Shi, Z; Sun, C; Sun, D; Wang, S; Yang, Z; Zhao, Z | 1 |
| He, W; Li, L; Liang, J; Su, Q; Sun, Y; Wang, X | 1 |
| Feng, C; Han, B; Liu, Y; Niu, D; Wang, L | 1 |
| Kong, B; Lv, X; Qin, Z; Su, Q; Sun, Y; Ye, Z | 1 |
| Li, Y; Liu, H; Peng, W; Song, Z | 1 |
| Li, L; Long, M; Lu, H; Su, Q; Ye, Z | 1 |
| Li, K; Sun, H; Wang, L; Xu, L; Yang, X; Zhang, Z | 1 |
| Ji, Z; Lu, W; Ma, G; Qu, Y; Zhang, R | 1 |
| Kapoor, S | 1 |
| Horiuchi, M; Miura, S; Murasato, Y; Saku, K; Suematsu, Y; Takata, K; Yamamoto, T | 1 |
| Doi, Y; Hayashi, T; Ito, N; Kai, T; Kawata, A; Kurozumi, Y; Morita, M; Nanto, S; Natsukawa, T; Okada, K; Sakata, Y; Sawano, H; Shibata, H; Tsuruoka, A | 1 |
| Cha, KS; Choi, JH; Hong, TJ; Hwang, J; Kim, BW; Kim, SP; Lee, HC; Lee, HW; Oh, J; Park, JH; Park, JS; Song, S; Yang, MJ | 1 |
| Cha, KS; Choi, JH; Jeong, MH; Kim, SP; Kim, W; Lee, HC; Lee, HW; Oh, JH; Park, JS; Yang, MJ | 1 |
| Huang, Z; Wu, M; Xie, H; Zhou, Z | 1 |
| Hashimoto, T; Iwamoto, N; Kobayashi, H; Nishida, M; Nishimura, M; Okamoto, Y; Okino, K; Ono, T; Sato, N; Takahashi, H; Tokoro, T; Yamazaki, S | 1 |
| Andreadou, I; Dagres, N; Iliodromitis, EK; Iliodromitis, K | 1 |
| Ding, J; Dong, W; Wang, X; Wu, H; Yang, J; Ye, M | 1 |
| Beleslin, B; Djordjevic-Dikic, A; Dobric, M; Kostic, J; Milasinovic, D; Nedeljkovic, M; Ostojic, M; Radosavljevic-Radovanovic, M; Stepanovic, J; Stojkovic, S; Tesic, M; Trifunovic, Z; Zamaklar-Tifunovic, D | 1 |
| Ishii, H; Isobe, S; Iwata, H; Murohara, T; Sawada, K; Yamada, K; Yokouchi, K | 1 |
| Amirthalingam, SK; Gopalakrishnan, S; Kurian, GA; Murali, J; Ravindran, S | 1 |
| An, SG; Choi, JH; Chun, KJ; Hong, TJ; Kim, J; Kim, JH; Lee, HC; Lee, SK; Lee, TK; Shin, YW | 1 |
| Adachi, Y; Doi, M; Naruse, S; Obata, Y; Sano, H; Sato, S; Suzuki, K; Takada, K | 1 |
| Baden, M; Iwasaka, T; Nakamura, S; Shimojo, M; Sugiura, T; Tsuka, Y; Umemura, S | 1 |
| Adachi, H; Hoshizaki, H; Kurabayashi, M; Murakami, J; Oshima, S; Toyama, T | 1 |
| Monassier, JP | 1 |
| Argaud, L; Couture-Lepetit, E; Garrier, O; Gateau-Roesch, O; Gomez, L; Loufouat, J; Ovize, M; Robert, D | 1 |
| Hashimoto, K; Komukai, K; Kosuga, T; Minai, K; Mochizuki, S; Nagoshi, T; Ogawa, K; Ogawa, T; Sakamoto, H; Taniguchi, I; Yoshida, S; Yoshimura, M | 1 |
| Hayashi, Y; Yamanaka, H | 1 |
| Date, M; Fujii, K; Higuchi, Y; Imai, M; Inoue, K; Ito, H; Ito, N; Iwakura, K; Kimura, R; Koyama, Y; Kubota, A; Nagai, H; Okamura, A; Okazaki, Y; Ozawa, M; Shibuya, M; Suenaga, H; Toyoshima, Y | 1 |
| Chang, NC; Chen, CC; Kang, CS; Lee, TM; Lin, CC | 1 |
| Hashimoto, T; Imai, R; Iwamoto, N; Kobayashi, H; Nishida, M; Nishimura, M; Okino, K; Ono, T; Takahashi, H; Tokoro, T; Yamazaki, S | 1 |
| Tan, KT | 1 |
| Horinaka, S; Ishimitsu, T; Kohro, T; Nagai, R; Suzuki, S; Yabe, A; Yagi, H; Yamazaki, T | 1 |
| Doi, Y; Hayashi, T; Hayashi, Y; Ito, N; Kai, T; Kaibe, S; Masuda, D; Nanto, S; Okada, K; Sawano, H; Yamashita, S | 1 |
| Asakura, M; Kitakaze, M | 1 |
| Fujiwara, Y; Ikeda, T; Kobatake, R; Saito, H; Sato, T; Sunami, H; Ujihira, T; Yoshioka, R | 1 |
| Enomoto-Uemura, S; Keira, N; Kojima, A; Matsubara, H; Naito, D; Nishikawa, S; Nomura, T; Tatsumi, T; Urakabe, Y | 1 |
| Hamasaki, T; Hara, M; Hori, M; Iwakura, K; Kawano, S; Komuro, I; Matsumoto, S; Nakatani, D; Nanto, S; Sakata, Y; Sato, H; Shimizu, M; Sumitsuji, S; Suna, S; Usami, M | 1 |
| Hashimoto, T; Iwamoto, N; Kobayashi, H; Murakawa, M; Nishida, M; Nishimura, M; Okamoto, Y; Ono, T; Sakoda, C; Sato, N; Takahashi, H; Tokoro, T; Yamazaki, S | 1 |
| Chang, PC; Chou, CC; Chu, Y; Lee, HL; Wen, MS; Wo, HT; Wu, D; Yeh, SJ | 1 |
| Chujo, M; Higgins, CB; Krombach, GA; Lund, GK; Saeed, M; Watzinger, N; Wendland, MF | 1 |
| Genda, S; Ichikawa, Y; Miki, T; Miura, T; Shimamoto, K | 1 |
| Ostrovskiĭ, IuP; Sidorenko, GI | 1 |
| Kato, T; Yoshimoto, N | 1 |
| Ambrosi, P; Andréjak, M; Gayet, JL | 1 |
| Devaki, T; Ebenezar, KK; Sathish, V | 3 |
| Fujii, K; Ikushima, M; Ito, H; Iwakura, K; Kato, A; Kawano, S; Kimura, R; Masuyama, T; Ogihara, T; Sugimoto, K; Tanaka, K | 1 |
| Cokkinos, P; Iliodromitis, EK; Kremastinos, DT; Steliou, I; Vrettou, AR; Zoga, A | 1 |
| Miura, T; Nakamura, Y | 1 |
| Das, B; Sarkar, C | 1 |
| Bolli, R; Shirk, G; Tang, XL; Xuan, YT; Zhu, Y | 1 |
| Beguier, B; Wajima, T; Yaguchi, M | 1 |
| Fujii, M; Hashimoto, S; Ikeda, N; Kawakami, M; Kubo, N; Saito, M; Tsuruya, Y; Yasu, T | 1 |
| Asakura, M; Asanuma, H; Jiyoong, K; Kitakaze, M; Minamino, T; Shintani, Y | 1 |
| Ishibashi, I; Komiyama, N; Komuro, I; Kuriyama, N; Masuda, Y; Miyazaki, Y; Nameki, M; Namikawa, S; Sakai, Y; Tsunoda, K | 1 |
| Kaikita, K; Kojima, S; Miyamoto, S; Ogawa, H; Sakamoto, T; Sugiyama, S; Yoshimura, M | 1 |
| Kurihara, H; Matsumoto, S; Matsuyama, T; Nakagawa, T; Nakata, A; Tamura, R; Yachiku, K; Yoshino, T | 1 |
| Asakawa, H; Horinaka, S; Kobayashi, N; Matsuoka, H; Mori, Y; Nakano, S; Tsubokou, Y; Yabe, A; Yagi, H; Yoshida, K | 1 |
| Hayashi, T; Nakayama, Y; Tsumura, K; Ueda, H; Yoshikawa, J; Yoshimaru, K | 1 |
| Maddock, HL; Siedlecka, SM; Yellon, DM | 1 |
| Ahn, YK; Bae, EH; Cho, JG; Hong, SN; Hong, YJ; Jeong, MH; Kang, DG; Kang, JC; Kim, JH; Kim, KH; Kim, W; Lee, SH; Lee, YS; Lim, SY; Park, HW; Park, JC; Yoon, KH | 1 |
| Fujita, N; Hanada, H; Ishizaka, H; Kamada, T; Matsunaga, T; Okumura, K; Ono, H; Onodera, H; Osanai, T; Sasaki, S | 1 |
| Bin, JP; Cha, DG; Feng, L; Huang, XB; Ma, J; Qiu, J | 1 |
| Ichikawa, S; Kasama, S; Kumakura, H; Kurabayashi, M; Suzuki, T; Takayama, Y; Toyama, T | 1 |
| Alfayoumi, F; Geller, M; Gradman, A; Srinivasan, V | 1 |
| Chen, JL; Chen, ZJ; Gao, RL; Jing, ZC; Meng, L; Tian, Y; Wu, YJ; Yang, WX; Yang, YJ; You, SJ; Zhao, JL | 1 |
| Danchin, N; Jullien, G; Mosnier, M | 1 |
| Amano, T; Ichimiya, S; Imai, K; Ishii, H; Kanashiro, M; Matsubara, T; Murohara, T | 1 |
| Kitano, M; Matsui, K; Mori, M; Ogawa, S; Ohashi, N; Yamada, K; Yamamoto, S | 1 |
| Amano, T; Ichimiya, S; Ishii, H; Kanashiro, M; Matsubara, T; Murohara, T | 1 |
| Kloner, RA; Rezkalla, SH | 1 |
| Akagi, T; Hama, N; Hamanaka, I; Hiraoka, Y; Inai, Y; Kitagawa, M; Matsumoto, N; Nakazawa, K; Sarazawa, K; Takahashi, N; Takebe, M; Ueda, K; Yamazaki, T | 1 |
| Chen, JL; Gao, RL; Kang, LM; Wu, Y; Yang, YJ; Zhao, JL | 1 |
| Adachi, H; Hoshizaki, H; Isobe, N; Kasama, S; Kawaguchi, R; Oshima, S; Seki, R; Taniguchi, K; Toyama, T | 1 |
| Makino, K; Nakajima, K; Nakamura, T; Nakano, T; Nishikawa, H; Okamoto, S; Ota, S; Setsuda, M; Takeuchi, M; Yamakado, T | 1 |
| Hara, H; Horinaka, S; Iemura, T; Matsuoka, H; Tsuboko, Y; Yabe, A; Yagi, H; Yoshida, K | 1 |
| Amano, T; Ichimiya, S; Ishii, H; Kanashiro, M; Matsubara, T; Mitsuhashi, H; Murakami, R; Murohara, T; Naruse, K; Ogawa, Y; Sakai, S; Uetani, T | 1 |
| Ichikawa, S; Kasama, S; Kumakura, H; Kurabayashi, M; Sumino, H; Suzuki, T; Takayama, Y; Toyama, T | 1 |
| Abe, N; Fujiwara, T; Hanada, H; Higuma, T; Kameda, K; Matsunaga, T; Okumura, K; Ono, H; Osanai, T; Yokoyama, J | 1 |
| Chang, NC; Lee, TM; Lin, MS | 2 |
| Bogle, R; Wilkins, M | 1 |
| Asakura, M; Asanuma, H; Fujii, K; Fukuzawa, S; Hamasaki, T; Hirayama, A; Ishihara, M; Kim, J; Kimura, K; Kitakaze, M; Kitamura, S; Minamino, T; Myoishi, M; Nagai, Y; Nakamura, N; Nanto, S; Ohara, T; Saito, Y; Seguchi, O; Shintani, Y; Tomoike, H; Watanabe, K | 1 |
| Gao, RL; Pei, WD; Sun, YH; Yang, YJ; Zhai, M; Zhang, YH; Zhao, JL | 1 |
| Aggeli, IK; Beis, I; Gaitanaki, C; Iliodromitis, EK; Kremastinos, DT; Tsiafoutis, I; Zoga, A | 1 |
| Ban, M; Enomoto, I; Hashimoto, H; Ito, T; Ogawa, K; Sakai, K | 1 |
| Gross, GJ; Mizumura, T; Nithipatikom, K | 2 |
| Auchampach, JA; Gross, GJ; Pieper, GM; Yao, Z | 1 |
| Hosoi, H; Hou, M; Igarashi, M; Iida, M; Ishiguro, S; Koyama, N; Morishita, T; Nakano, H; Yabe, Y; Yamazaki, J | 1 |
| Auchampach, JA; Gross, GJ | 1 |
| Blin, P; Guermonprez, JL; Peterlongo, F | 1 |
| Roland, E | 1 |
| Hosoi, H; Iida, M; Komatsu, H; Koyama, N; Morishita, T; Nakano, H; Ohsawa, H; Uchi, T; Yabe, Y; Yamazaki, J | 1 |
| Branzi, A; Galiè, N; Guarnieri, C; Magnani, B; Parlangeli, R; Traini, AM; Ussia, GP; Vaona, I; Zimarino, M | 1 |
| Ejima, J; Fujino, T; Kaji, Y; Kanaya, S; Kaneda, K; Maruyama, T; Moriyama, H; Niho, Y; Ohmura, I; Tsuda, Y | 1 |
| Chujo, M; Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Hasegawa, S; Hirayama, A; Ishikura, F; Kodama, K; Komamura, K; Sakata, Y | 1 |
| Hirayama, A; Hori, M; Ishikura, F; Kitakaze, M; Kodama, K; Komamura, K; Lim, YJ; Masuyama, T; Sakata, Y | 1 |
| Cavero, I; Gross, GJ; Schultz, JE; Yao, Z | 1 |
| André-Fouät, X; Loufoua, J; Minaire, Y; Ovize, M; Pop, C; Rioufol, G | 1 |
| Baxter, GF; Imagawa, J; Yellon, DM | 1 |
| Arai, M; Fujiwara, H; Fujiwara, T; Kariya, T; Minatoguchi, S; Ohno, Y; Uno, Y; Yamashita, K | 1 |
| Daikoku, S; Goto, Y; Haze, K; Itoh, A; Kobayashi, Y; Miyazaki, S; Nonogi, H; Ohshima, S | 1 |
| Fujii, K; Higashino, Y; Hori, M; Ito, H; Iwakura, K; Kuzuya, T; Masuyama, T; Minamino, T; Nishikawa, N; Taniyama, Y | 1 |
| Dohi, K; Fujimoto, S; Hashimoto, T; Inoue, F; Kawamoto, A; Uemura, S | 1 |
| Gross, ER; Kersten, JR; Pagel, PS; Toller, WG; Warltier, DC | 1 |
| Gen, H; Himura, Y; Hirozane, T; Iga, K; Inoko, M; Izumi, C; Kitaguchi, S; Kondo, H; Konishi, T; Tamura, T | 1 |
| Kitano, M; Matsui, K; Ohashi, N; Satoh, K; Yamada, K; Yamamoto, S | 1 |
| Ito, M; Kinoshita, M; Matsumoto, T; Mitsunami, K; Nakae, I; Omura, T; Takaoka, A; Yabe, T; Yokohama, H | 1 |
| Ahn, YK; Bae, Y; Cho, JG; Cho, JH; Jeong, MH; Kang, JC; Kang, KT; Kim, KH; Kim, NH; Kim, SH; Lee, SH; Park, JC; Rhew, JY | 1 |
| Asakura, M; Asanuma, H; Harada, K; Hori, M; Kitakaze, M; Kuzuya, T; Mori, H; Node, K; Ogita, H; Sakata, Y; Sanada, S; Shinozaki, Y; Takashima, S | 1 |
| Arai, M; Chen, XH; Fujiwara, H; Hashimoto, K; Hashimoto, Y; Minatoguchi, S; Takemura, G; Uno, Y; Wang, N | 1 |
| Hikawa, Y; Kaneko, T; Makita, K; Saito, Y; Yasuda, K | 1 |
| Higgins, CB; Lund, GK; Saeed, M; Watzinger, N; Weinmann, HJ; Wendland, MF | 1 |
| SoRelle, R | 1 |
| Matsui, K; Ohashi, N; Sasabe, M; Yamamoto, S | 1 |
| Devaki, T; Ebenezar, KK; Sathish, V; Vimal, V | 1 |
| Das, B; Karanth, KS; Sarkar, C | 1 |
| Chujo, M; Higgins, CB; Krombach, GA; Saeed, M | 1 |
| Bache, RJ; Murakami, Y; Ochiai, K; Shimada, T; Wu, X; Zhang, J | 1 |
| Auchampach, JA; Gross, GJ; Maruyama, M; Pieper, GM; Warltier, DC | 1 |
| Baas, NR; van der Giessen, WJ; van Woerkens, LJ; Verdouw, PD | 1 |
| Fukuma, N; Hata, N; Hayakawa, H; Kishida, H; Saito, T; Tada, Y; Tetsuoh, Y; Yamazaki, Y; Yasutake, M | 1 |
| Inagaki, H; Matsunami, T; Sotobata, I; Tsuzuki, J; Watanabe, M; Yokota, M | 1 |
| Gross, GJ; Hardman, HF; Warltier, DC | 1 |
| Horisawa, T; Iwase, M; Kamihara, S; Koide, M; Miyahara, T; Noda, S; Tsunekawa, A; Tsuzuki, M; Yokota, M; Yoshida, J | 1 |
| Endo, T; Fujita, S; Hayakawa, H; Kikuchi, K; Kiuchi, K; Nejima, J; Okumura, H | 1 |
17 review(s) available for nicorandil and Cardiovascular Stroke
| Article | Year |
|---|---|
Effects of Intracoronary Nicorandil on Myocardial Microcirculation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials.
Topics: Anti-Arrhythmia Agents; Humans; Microcirculation; Myocardial Infarction; Myocardial Reperfusion; Nicorandil; Percutaneous Coronary Intervention; Randomized Controlled Trials as Topic; Treatment Outcome | 2020 |
Nicorandil for Periprocedural Myocardial Injury in Elective Percutaneous Coronary Intervention: A Meta-Analysis of 10 Randomized Controlled Trials.
Topics: Aged; Coronary Artery Disease; Elective Surgical Procedures; Female; Heart Injuries; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Randomized Controlled Trials as Topic; Treatment Outcome | 2020 |
Effect of nicorandil treatment adjunctive to percutaneous coronary intervention in patients with acute myocardial infarction: a systematic review and meta-analysis.
Topics: Humans; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Stroke Volume; Ventricular Function, Left | 2020 |
Nicorandil improves clinical outcomes in patients with stable angina pectoris requiring PCI: a systematic review and meta-analysis of 14 randomized trials.
Topics: Angina, Stable; Anti-Arrhythmia Agents; Contrast Media; Coronary Artery Disease; Humans; Kidney Diseases; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Randomized Controlled Trials as Topic | 2018 |
Nicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials.
Topics: Acute Disease; Antihypertensive Agents; Humans; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Randomized Controlled Trials as Topic; Treatment Outcome | 2019 |
The effect of nicorandil in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Topics: Acute Disease; Female; Humans; Male; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Prognosis; Randomized Controlled Trials as Topic; Vasodilator Agents | 2020 |
Nicorandil in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Female; Heart Failure; Humans; Male; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; PubMed; Risk Factors; Stroke Volume; Thrombolytic Therapy | 2013 |
Reperfusion injury in acute myocardial infarction: from bench to cath lab. Part II: Clinical issues and therapeutic options.
Topics: Adenosine; Angioplasty, Balloon, Coronary; Animals; Coronary Circulation; Electrocardiography; Heart Conduction System; Humans; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Nicorandil; No-Reflow Phenomenon; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombectomy; Treatment Outcome; Vasodilator Agents | 2008 |
[Myocardial preconditioning in anesthesia: from bench to bedside].
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cardiovascular Surgical Procedures; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; KATP Channels; Myocardial Infarction; Nicorandil; Perioperative Care; Postoperative Complications | 2009 |
Nicorandil treatment in patients with acute myocardial infarction: a meta-analysis.
Topics: Aged; Cardiovascular Agents; Combined Modality Therapy; Coronary Circulation; Female; Humans; Male; Microcirculation; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Nicorandil; No-Reflow Phenomenon; Publication Bias; Recovery of Function; Stroke Volume; Treatment Outcome; Ventricular Function, Left | 2009 |
[The no-reflow phenomenon and its clinical significance].
Topics: Adenosine; Angioplasty, Balloon, Coronary; Atherectomy; Coronary Angiography; Coronary Artery Bypass; Coronary Circulation; Coronary Disease; Heart Failure; Hospital Mortality; Humans; Microvascular Angina; Myocardial Infarction; Nicorandil; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Stents; Vasodilator Agents; Verapamil | 2002 |
Ischaemic preconditioning and outcomes after angioplasty: effects of drug therapy.
Topics: Adenosine; Angina Pectoris; Angioplasty, Balloon, Coronary; Bradykinin; Death, Sudden, Cardiac; Humans; Ischemic Preconditioning, Myocardial; Models, Biological; Myocardial Infarction; Nicorandil; Nitroglycerin; Potassium Channels; Randomized Controlled Trials as Topic; Receptors, Purinergic P1 | 2003 |
[The best of clinical pharmacology in 2002].
Topics: Anticholesteremic Agents; Antihypertensive Agents; Azetidines; Cardiovascular Diseases; Ezetimibe; Hormone Replacement Therapy; Humans; Hydrazones; Hypercholesterolemia; Losartan; Myocardial Infarction; Natriuretic Agents; Natriuretic Peptide, Brain; Neovascularization, Physiologic; Nicorandil; Pyridazines; Randomized Controlled Trials as Topic; Simendan; Vasodilator Agents | 2003 |
[Anti-ischemic tolerance and preconditioning].
Topics: Adenosine Triphosphate; Animals; Humans; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Infarction; Nicorandil; Potassium Channels; Reactive Oxygen Species; Signal Transduction | 2003 |
Nicorandil for angina--an update.
Topics: Angina Pectoris; Humans; Myocardial Infarction; Nicorandil; Treatment Outcome; Vasodilator Agents | 2003 |
The no-reflow phenomenon: epidemiology, pathophysiology, and therapeutic approach.
Topics: Adenosine; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Echocardiography; Humans; Microcirculation; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Single-Chain Antibodies; Thrombolytic Therapy; Vascular Patency; Vasodilator Agents; Verapamil | 2005 |
Preconditioning, postconditioning and their application to clinical cardiology.
Topics: Adenosine; Angioplasty, Balloon, Coronary; Humans; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Nicorandil; Randomized Controlled Trials as Topic; Stents; Vasodilator Agents | 2006 |
41 trial(s) available for nicorandil and Cardiovascular Stroke
| Article | Year |
|---|---|
Protective effect of ischaemic postconditioning combined with nicorandil on myocardial ischaemia‒reperfusion injury in diabetic rats.
Topics: Animals; Creatine Kinase, MB Form; Diabetes Mellitus, Experimental; Heart Injuries; Ischemic Postconditioning; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species | 2022 |
The effect of nicorandil on cardiac function and clinical outcomes in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: a randomised trial.
Topics: Humans; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Prospective Studies; ST Elevation Myocardial Infarction; Treatment Outcome | 2023 |
Myocardial protective effect of intracoronary administration of nicorandil and alprostadil via targeted perfusion microcatheter in patients undergoing elective percutaneous coronary intervention: A randomized controlled trial.
Topics: Aged; Alprostadil; Cardiotonic Agents; Drug Administration Routes; Elective Surgical Procedures; Female; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Nitroglycerin; Percutaneous Coronary Intervention; Perfusion; Prospective Studies; Single-Blind Method; Treatment Outcome; Vasodilator Agents | 2021 |
Effects of Early Intracoronary Administration of Nicorandil During Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction.
Topics: Aged; Disease-Free Survival; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Survival Rate; Thrombectomy | 2019 |
Efficacy and safety of nicorandil on perioperative myocardial injury in patients undergoing elective percutaneous coronary intervention: results of the PENMIPCI trial.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Prospective Studies; Young Adult | 2018 |
Beneficial effects of intracoronary nicorandil on microvascular dysfunction after primary percutaneous coronary intervention: demonstration of its superiority to nitroglycerin in a cross-over study.
Topics: Aged; Cross-Over Studies; Drug Administration Routes; Female; Humans; Male; Microvessels; Middle Aged; Myocardial Infarction; Nicorandil; Nitric Oxide Donors; Nitroglycerin; Percutaneous Coronary Intervention; Vascular Resistance | 2013 |
Effect on periprocedural myocardial infarction of intra-coronary nicorandil prior to percutaneous coronary intervention in stable and unstable angina.
Topics: Aged; Angina, Stable; Angina, Unstable; Coronary Vessels; Creatine Kinase, MB Form; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Myocardium; Nicorandil; Percutaneous Coronary Intervention; Postoperative Complications; Prognosis; Prospective Studies; Troponin I; Vasodilator Agents | 2013 |
Clinical potential of oral nicorandil to improve myocardial fatty acid metabolism after percutaneous coronary intervention in hemodialysis patients.
Topics: Aged; Coronary Artery Disease; Death, Sudden, Cardiac; Fatty Acids; Female; Follow-Up Studies; Heart; Heart Failure; Humans; Iodine Radioisotopes; Iodobenzenes; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Myocardium; Nicorandil; Percutaneous Coronary Intervention; Renal Dialysis; Renal Insufficiency, Chronic; Survival Rate; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 2014 |
The effects of nicorandil on microvascular function in patients with ST segment elevation myocardial infarction undergoing primary PCI.
Topics: Cardiotonic Agents; Coronary Artery Disease; Female; Humans; Male; Microcirculation; Middle Aged; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Treatment Outcome; Ultrasonography | 2015 |
Impacts of nicorandil on infarct myocardium in comparison with nitrate: assessed by cardiac magnetic resonance imaging.
Topics: Aged; Biomarkers; Coronary Circulation; Coronary Vessels; Creatine Kinase, MB Form; Edema, Cardiac; Female; Humans; Isosorbide Dinitrate; Japan; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction; Nicorandil; Nitroglycerin; Percutaneous Coronary Intervention; Pilot Projects; Predictive Value of Tests; Time Factors; Treatment Outcome; Vasodilator Agents | 2016 |
Effect of intra-coronary nicorandil administration prior to reperfusion in acute ST segment elevation myocardial infarction.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Catheterization; Coronary Circulation; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Retrospective Studies; Thrombolytic Therapy | 2008 |
Oral nicorandil to reduce cardiac death after coronary revascularization in hemodialysis patients: a randomized trial.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Death, Sudden, Cardiac; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Postoperative Complications; Prospective Studies; Renal Dialysis; Vasodilator Agents | 2009 |
Effects of nicorandil on cardiovascular events in patients with coronary artery disease in the Japanese Coronary Artery Disease (JCAD) study.
Topics: Adult; Aged; Aged, 80 and over; Cardiotonic Agents; Coronary Artery Disease; Death, Sudden, Cardiac; Female; Follow-Up Studies; Humans; Incidence; Japan; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Prognosis; Proportional Hazards Models; Registries; Risk Factors; Treatment Outcome | 2010 |
High index of microcirculatory resistance level after successful primary percutaneous coronary intervention can be improved by intracoronary administration of nicorandil.
Topics: Aged; Anti-Arrhythmia Agents; Catheter Ablation; Female; Humans; Male; Microcirculation; Middle Aged; Myocardial Infarction; Nicorandil; Prospective Studies; Vascular Resistance | 2010 |
Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Female; Humans; Male; Myocardial Infarction; Nicorandil; Patient Discharge; Vasodilator Agents | 2012 |
Nicorandil versus isosorbide dinitrate as adjunctive treatment to direct balloon angioplasty in acute myocardial infarction.
Topics: Angioplasty, Balloon; Chemotherapy, Adjuvant; Coronary Circulation; Double-Blind Method; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Nicorandil; Prospective Studies; Treatment Outcome; Vasodilator Agents | 2004 |
Rationale and design of a large-scale trial using nicorandil as an adjunct to percutaneous coronary intervention for ST-segment elevation acute myocardial infarction: Japan-Working groups of acute myocardial infarction for the reduction of Necrotic Damage
Topics: Adult; Aged; Biomarkers; Cardiac Surgical Procedures; Clinical Protocols; Creatine Kinase; Data Collection; Electrocardiography; Humans; Middle Aged; Myocardial Infarction; Necrosis; Nicorandil; Potassium Channels; Reperfusion Injury; Research Design; Sample Size; Troponin T; Ventricular Function, Left | 2004 |
Comparison between nicorandil and magnesium as an adjunct cardioprotective agent to percutaneous coronary intervention in acute anterior myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiotonic Agents; Female; Humans; Infusions, Intravenous; Magnesium; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Nicorandil; Risk Factors | 2004 |
Clinical outcome of percutaneous coronary intervention with antecedent mutant t-PA administration for acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Combined Modality Therapy; Coronary Angiography; Coronary Restenosis; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Plasminogen Activators; Platelet Aggregation Inhibitors; Stents; Vasodilator Agents | 2004 |
Intravenous nicorandil can reduce the occurrence of ventricular fibrillation and QT dispersion in patients with successful coronary angioplasty in acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Cohort Studies; Coronary Angiography; Electrocardiography; Female; Humans; Injections, Intravenous; Male; Middle Aged; Myocardial Infarction; Nicorandil; Ventricular Fibrillation | 2004 |
Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: role of inhibitory effect on reactive oxygen species formation.
Topics: Aged; Angioplasty, Balloon, Coronary; Combined Modality Therapy; Dinoprost; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Premedication; Pulmonary Wedge Pressure; Reactive Oxygen Species; Stroke Volume; Treatment Outcome; Vasodilator Agents; Ventricular Function, Left | 2004 |
Impact of nicorandil in angina: subgroup analyses.
Topics: Angina Pectoris; Confidence Intervals; Coronary Disease; Double-Blind Method; Female; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Proportional Hazards Models; Risk Factors; Treatment Outcome; Vasodilator Agents | 2004 |
Effects of nicorandil on cardiac sympathetic nerve activity after reperfusion therapy in patients with first anterior acute myocardial infarction.
Topics: 3-Iodobenzylguanidine; Angioplasty, Balloon, Coronary; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nicorandil; Prognosis; Radionuclide Imaging; Radiopharmaceuticals; Sympathetic Nervous System; Treatment Outcome; Vasodilator Agents; Ventricular Dysfunction, Left | 2005 |
Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction.
Topics: Adult; Aged; Double-Blind Method; Electrocardiography; Female; Humans; Injections, Intravenous; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Potassium Channels | 2005 |
Effects of intravenous nicorandil before reperfusion for acute myocardial infarction in patients with stress hyperglycemia.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Glucose; Cardiotonic Agents; Combined Modality Therapy; Coronary Angiography; Creatine Kinase; Diabetes Complications; Disease-Free Survival; Electrocardiography; Female; Follow-Up Studies; Humans; Hyperglycemia; Injections, Intravenous; Male; Middle Aged; Myocardial Infarction; Nicorandil; Proportional Hazards Models; Prospective Studies | 2006 |
Continuous administration of nicorandil decreases QT dispersion during the chronic phase of acute myocardial infarction.
Topics: Administration, Oral; Aged; Echocardiography; Electrocardiography; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Nicorandil; Prognosis; Stroke Volume; Vasodilator Agents; Ventricular Function, Left | 2006 |
Nicorandil administration shows cardioprotective effects in patients with poor TIMI and collateral flow as well as good flow after AMI.
Topics: Blood Flow Velocity; Cardiotonic Agents; Coronary Circulation; Female; Humans; Male; Myocardial Infarction; Nicorandil; Prognosis; Radionuclide Imaging; Treatment Outcome; Ventricular Dysfunction, Left | 2006 |
Impact of nicorandil to prevent reperfusion injury in patients with acute myocardial infarction: Sigmart Multicenter Angioplasty Revascularization Trial (SMART).
Topics: Aged; Angioplasty, Balloon, Coronary; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Recovery of Function; Vasodilator Agents | 2006 |
[Suppressive effect of nicorandil in ventricular arrhythmias after reperfusion therapy in patients with acute myocardial infarction].
Topics: Aged; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Nicorandil; Tachycardia, Ventricular | 2007 |
Effect of intravenous nicorandil and preexisting angina pectoris on short- and long-term outcomes in patients with a first ST-segment elevation acute myocardial infarction.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Nicorandil; Time Factors; Treatment Outcome; Vasodilator Agents | 2007 |
Long-term nicorandil therapy improves cardiac sympathetic nerve activity after reperfusion therapy in patients with first acute myocardial infarction.
Topics: Aged; Chemotherapy, Adjuvant; Double-Blind Method; Female; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Nicorandil; Radionuclide Imaging; Sympathetic Nervous System; Treatment Outcome; Vasodilator Agents | 2007 |
Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction.
Topics: Acute Disease; Aged; Angiography; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression Regulation; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Middle Aged; Myocardial Infarction; Nicorandil; Vasodilator Agents; Ventricular Remodeling | 2007 |
Treating acute myocardial infarction: something in the wind?
Topics: Atrial Natriuretic Factor; Humans; Japan; Myocardial Infarction; Nicorandil; Treatment Failure; Vasodilator Agents | 2007 |
Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials.
Topics: Atrial Natriuretic Factor; Creatine Kinase; Female; Humans; Infusions, Intravenous; Japan; Male; Middle Aged; Myocardial Infarction; Nicorandil; Reperfusion Injury; Vasodilator Agents | 2007 |
A double-blind comparison of the long-term efficacy of a potassium channel opener and a calcium antagonist in stable angina pectoris.
Topics: Aged; Angina Pectoris; Coronary Circulation; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1993 |
Coronary dilating effects of intracoronary nicorandil. Comparison with isosorbide dinitrate.
Topics: Angina Pectoris; Atrial Fibrillation; Cardiomyopathy, Hypertrophic; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Female; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Niacinamide; Nicorandil; Sick Sinus Syndrome; Vasodilator Agents | 1995 |
Salutary effect of adjunctive intracoronary nicorandil administration on restoration of myocardial blood flow and functional improvement in patients with acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Contrast Media; Coronary Circulation; Coronary Vessels; Echocardiography; Female; Humans; Injections; Ioxaglic Acid; Male; Microcirculation; Middle Aged; Myocardial Contraction; Myocardial Infarction; Niacinamide; Nicorandil; Platelet Aggregation Inhibitors; Potassium Channels; Thrombolytic Therapy | 1997 |
Cardioprotective effect of intravenous nicorandil in patients with successful reperfusion for acute myocardial infarction.
Topics: Acute Disease; Anti-Arrhythmia Agents; Humans; Injections, Intravenous; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels | 1998 |
Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Cardiac Catheterization; Coronary Angiography; Coronary Vessels; Echocardiography; Female; Follow-Up Studies; Heart Ventricles; Humans; Injections, Intravenous; Male; Middle Aged; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Potassium Channels; Prognosis; Radionuclide Ventriculography; Retrospective Studies; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1999 |
Trial to show the impact of nicorandil in angina (IONA): design, methodology, and management.
Topics: Angina Pectoris; Chest Pain; Cohort Studies; Coronary Disease; Double-Blind Method; Female; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Research Design; Risk Factors; Treatment Outcome; Vasodilator Agents | 2001 |
Dose-dependent prophylactic effect of nicorandil, an ATP-sensitive potassium channel opener, on intra-operative myocardial ischaemia in patients undergoing major abdominal surgery.
Topics: Abdomen; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Intraoperative Complications; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Postoperative Complications; Prospective Studies; Risk Factors; Vasodilator Agents | 2001 |
92 other study(ies) available for nicorandil and Cardiovascular Stroke
| Article | Year |
|---|---|
Nicorandil alleviates cardiac remodeling and dysfunction post -infarction by up-regulating the nucleolin/autophagy axis.
Topics: Animals; Apoptosis; Autophagy; Hydrogen Peroxide; Mice; Myocardial Infarction; Myocytes, Cardiac; Nicorandil; Nucleolin; Phosphoproteins; RNA-Binding Proteins; Ventricular Remodeling | 2022 |
Nicorandil Suppresses Ischemia-Induced Norepinephrine Release and Ventricular Arrhythmias in Hypertrophic Hearts.
Topics: Animals; Arrhythmias, Cardiac; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Norepinephrine; Potassium Channels; Rats | 2023 |
CoO Nanoparticles Combined with MRI: Analysis of No-Reflow in Patients with Acute ST-Segment Elevation Myocardial Infarction after PCI and the Effect of Coronary Nicorandil.
Topics: Arrhythmias, Cardiac; Humans; Magnetic Resonance Imaging; Myocardial Infarction; Nanoparticles; Nicorandil; Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction; Treatment Outcome | 2022 |
Effectiveness of intraoperative nicorandil in patients with a history of ischemic heart disease undergoing high-risk noncardiac surgery: a retrospective cohort study.
Topics: Hospital Mortality; Humans; Intraoperative Care; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Percutaneous Coronary Intervention; Retrospective Studies; Surgical Procedures, Operative | 2023 |
Nicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials [Letter].
Topics: Humans; Myocardial Infarction; Nicorandil; Percutaneous Coronary Intervention; Randomized Controlled Trials as Topic | 2019 |
Intracoronary pressure gradient measurement in acute myocardial infarction patients with the no-reflow phenomenon during primary percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Arterial Pressure; Blood Pressure; Coronary Circulation; Female; Hemodynamics; Humans; Male; Microcirculation; Middle Aged; Myocardial Infarction; Nicorandil; No-Reflow Phenomenon; Percutaneous Coronary Intervention | 2020 |
Intracoronary application of nicorandil regulates the inflammatory response induced by percutaneous coronary intervention.
Topics: Aged; Coronary Vessels; Female; Heart; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Myocardium; Nicorandil; Percutaneous Coronary Intervention; Proteomics | 2020 |
Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K/Akt/eNOS pathway.
Topics: Animals; Cell Survival; Cells, Cultured; Chromones; Endothelial Cells; Homocysteine; Humans; Hyperhomocysteinemia; Hypoxia; Male; Mice; Microcirculation; Morpholines; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Nicorandil; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Plant Lectins; Platelet Endothelial Cell Adhesion Molecule-1; Proto-Oncogene Proteins c-akt; Ventricular Function, Left | 2020 |
Nicorandil inhibits cardiomyocyte apoptosis and improves cardiac function by suppressing the HtrA2/XIAP/PARP signaling after coronary microembolization in rats.
Topics: Animals; Anti-Arrhythmia Agents; Aorta; Apoptosis; Apoptosis Regulatory Proteins; Embolism; Female; Inhibitor of Apoptosis Proteins; Male; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Nerve Tissue Proteins; Nicorandil; Poly(ADP-ribose) Polymerase Inhibitors; Rats, Sprague-Dawley; Serine-Arginine Splicing Factors; Signal Transduction | 2021 |
Impact of administration of nicorandil prior to percutaneous coronary intervention in treatment of acute myocardial infarction: A protocol for systematic review and meta-analysis.
Topics: Acute Disease; Combined Modality Therapy; Humans; Meta-Analysis as Topic; Myocardial Infarction; Nicorandil; Observational Studies as Topic; Percutaneous Coronary Intervention; Preoperative Care; Randomized Controlled Trials as Topic; Research Design; Systematic Reviews as Topic; Treatment Outcome; Vasodilator Agents | 2021 |
Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.
Topics: Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Hepatocyte Growth Factor; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Nicorandil; Proto-Oncogene Proteins; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Remodeling | 2018 |
The protective effect of nicorandil on cardiomyocyte apoptosis after coronary microembolization by activating Nrf2/HO-1 signaling pathway in rats.
Topics: Animals; Apoptosis; Cardiotonic Agents; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); Myocardial Infarction; Myocytes, Cardiac; NF-E2-Related Factor 2; Nicorandil; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome | 2018 |
Role of TLR4/MyD88/NF-κB signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Coronary Stenosis; Cytoprotection; Disease Models, Animal; Embolism; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Male; Microspheres; Myeloid Differentiation Factor 88; Myocardial Infarction; Myocarditis; Myocytes, Cardiac; NF-kappa B; Nicorandil; Rats, Sprague-Dawley; Signal Transduction; Stroke Volume; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left; Ventricular Function, Left | 2018 |
Nicorandil and its associated gastrointestinal side effects.
Topics: Animals; Disease Models, Animal; Humans; Myocardial Infarction; Nicorandil; Ventricular Fibrillation | 2013 |
Safety and feasibility of high-dose administration of nicorandil before reperfusion therapy in acute myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Feasibility Studies; Follow-Up Studies; Humans; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Nicorandil; Prospective Studies; Treatment Outcome; Vasodilator Agents; Young Adult | 2013 |
Effect of nicorandil on clinical outcomes in patients with ST-segment elevation and non-ST-segment elevation myocardial infarction: based on the Korea Acute Myocardial Infarction Registry (KAMIR).
Topics: Administration, Oral; Anti-Arrhythmia Agents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Registries; Republic of Korea; Retrospective Studies; Treatment Outcome | 2013 |
Ischemic and postischemic conditioning of the myocardium in clinical practice: challenges, expectations and obstacles.
Topics: Adenosine; Cyclosporine; Enzyme Activators; Erythropoietin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Ischemic Postconditioning; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Nicorandil; Vasodilator Agents | 2014 |
Nicorandil Protects the Heart from Ischemia/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K/Akt Signaling Pathway.
Topics: Animals; Apoptosis; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Heart; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Ischemia; Nicorandil; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2015 |
Vascular calcification abrogates the nicorandil mediated cardio-protection in ischemia reperfusion injury of rat heart.
Topics: Animals; Biomarkers; Cardiovascular Agents; Cytoprotection; Disease Models, Animal; Energy Metabolism; Hemodynamics; Isolated Heart Preparation; Lipid Peroxidation; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nicorandil; Oxidative Stress; Potassium Channels; Rats, Wistar; Vascular Calcification | 2017 |
[Severe arrhythmia after gastrectomy in patients with history of coronary bypass graft surgery using right gastroepiploic artery].
Topics: Aged; Anesthesia; Angina Pectoris; Arrhythmias, Cardiac; Coronary Artery Bypass; Defibrillators, Implantable; Dobutamine; Gastrectomy; Gastroepiploic Artery; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Postoperative Complications; Severity of Illness Index; Stomach Neoplasms; Treatment Outcome | 2008 |
Preservation of myocardial viability within the risk area by intravenous nicorandil before primary coronary intervention in patients with acute myocardial infarction.
Topics: Acute Disease; Aged; Angioplasty, Balloon, Coronary; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Myocardium; Nicorandil; Organophosphorus Compounds; Organotechnetium Compounds; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 2008 |
Important factors for salvaging myocardium in patients with acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Radiopharmaceuticals; Technetium Tc 99m Pyrophosphate; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 2008 |
Second-generation sulfonylureas preserve inhibition of mitochondrial permeability transition by the mitochondrial K+(ATP) opener nicorandil in experimental myocardial infarction.
Topics: Animals; Calcium; Gliclazide; Glyburide; Hemodynamics; Male; Mitochondria; Myocardial Infarction; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rabbits; Sulfonylurea Compounds | 2009 |
High incidence of repeat anginal attacks despite treatment with calcium-channel blockers in patients with coronary spastic angina.
Topics: Acetylcholine; Aged; Angina Pectoris, Variant; Calcium Channel Blockers; Cardiac Catheterization; Coronary Vasospasm; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Nicorandil; Nitrates; Prognosis; Quality of Life; Recurrence; Treatment Outcome; Vasodilator Agents | 2009 |
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Echocardiography; Endothelin-1; Glyburide; Heart; Hypoglycemic Agents; Male; Myocardial Infarction; Nerve Growth Factor; Nicorandil; Norepinephrine; Pinacidil; Potassium Channels; Rats; Rats, Wistar; RNA, Messenger; Sympathetic Nervous System; Vasodilator Agents | 2009 |
Pathology, imaging and treatment of cardiac microvascular obstruction.
Topics: Adenosine; Coronary Vessels; Humans; Magnetic Resonance Angiography; Myocardial Infarction; Nicorandil; Nitroprusside; Vasodilator Agents; Verapamil | 2010 |
Cardioprotection in the clinical setting-lessons from J-WIND studies.
Topics: Atrial Natriuretic Factor; Cardiotonic Agents; Disease Progression; Heart Failure; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicorandil; Randomized Controlled Trials as Topic; Risk Factors; Vasodilator Agents | 2010 |
Comparison of the effects of nitroprusside versus nicorandil on the slow/no-reflow phenomenon during coronary interventions for acute myocardial infarction.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Chi-Square Distribution; Coronary Circulation; Female; Humans; Japan; Male; Middle Aged; Myocardial Infarction; Nicorandil; Nitroprusside; No-Reflow Phenomenon; Time Factors; Treatment Outcome; Vasodilator Agents | 2011 |
Effects of cardiologist experience on outcomes of patients with ST-elevated myocardial infarction treated with primary PCI in a local area in Japan.
Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Clinical Competence; Coronary Angiography; Coronary Circulation; Electrocardiography; Female; Hospital Mortality; Hospitals, General; Humans; Japan; Length of Stay; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Nicorandil; Treatment Outcome | 2011 |
Oral nicorandil for prevention of cardiac death in hemodialysis patients without obstructive coronary artery disease: a propensity-matched patient analysis.
Topics: Administration, Oral; Aged; Cardiovascular Agents; Coronary Angiography; Coronary Disease; Death, Sudden, Cardiac; Drug Evaluation; Female; Follow-Up Studies; Heart Failure; Humans; Insulin Resistance; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Middle Aged; Myocardial Infarction; Nicorandil; Proportional Hazards Models; Renal Dialysis; Retrospective Studies; Tomography, Emission-Computed, Single-Photon | 2011 |
Blunted proarrhythmic effect of nicorandil in a Langendorff-perfused phase-2 myocardial infarction rabbit model.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Humans; Myocardial Infarction; Nicorandil; Perfusion; Rabbits; Treatment Outcome; Ventricular Fibrillation | 2013 |
Left ventricular remodeling after infarction: sequential MR imaging with oral nicorandil therapy in rat model.
Topics: Administration, Oral; Animals; Cardiac Volume; Disease Models, Animal; Female; Heart Ventricles; Magnetic Resonance Imaging; Mesoporphyrins; Myocardial Infarction; Nicorandil; Rats; Rats, Sprague-Dawley; Stroke Volume; Vasodilator Agents; Ventricular Remodeling | 2002 |
K(ATP) channel opening is an endogenous mechanism of protection against the no-reflow phenomenon but its function is compromised by hypercholesterolemia.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Chronic Disease; Coronary Circulation; Disease Models, Animal; Glyburide; Hemodynamics; Hypercholesterolemia; Male; Myocardial Infarction; Nicorandil; Nitric Oxide Synthase; omega-N-Methylarginine; Potassium Channel Blockers; Potassium Channels; Rabbits; Vasodilator Agents | 2002 |
Synergistic effect of Nicorandil and Amlodipine on tissue defense system during experimental myocardial infarction in rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Antioxidants; Cholesterol; Drug Synergism; Fatty Acids; Lipid Metabolism; Lipid Peroxidation; Lipoproteins; Male; Myocardial Infarction; Nicorandil; Rats; Rats, Wistar; Time Factors | 2003 |
Intravenous nicorandil in conjunction with coronary reperfusion therapy is associated with better clinical and functional outcomes in patients with acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Case-Control Studies; Echocardiography; Female; Humans; Male; Microcirculation; Middle Aged; Myocardial Infarction; Nicorandil; Prognosis; Retrospective Studies; Time Factors; Vasodilator Agents; Ventricular Function, Left; Ventricular Remodeling | 2003 |
Oral nicorandil recaptures the waned protection from preconditioning in vivo.
Topics: Administration, Oral; Animals; Blood Pressure; Decanoic Acids; Disease Models, Animal; Drug Combinations; Heart Rate; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion; Nicorandil; Rabbits; Sodium-Potassium-Exchanging ATPase; Time Factors; Ventricular Fibrillation | 2003 |
Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Cromakalim; Decanoic Acids; Disease Models, Animal; Glutathione; Heart Rate; Hydroxy Acids; Male; Malondialdehyde; Membrane Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Oxidative Stress; Potassium Channels; Rabbits; Sarcolemma; Sulfonamides; Superoxide Dismutase; Survival Rate; Thiourea | 2003 |
Synergistic effect of nicorandil and amlodipine on lysosomal hydrolases during experimental myocardial infarction in rats.
Topics: Administration, Oral; Amlodipine; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Hydrolases; Injections, Intraperitoneal; Lysosomes; Male; Myocardial Infarction; Myocardium; Nicorandil; Rats; Rats, Wistar; Subcellular Fractions | 2003 |
Biochemical changes on the cardioprotective effect of nicorandil and amlodipine during experimental myocardial infarction in rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amlodipine; Animals; Cardiovascular Agents; Drug Synergism; Isoproterenol; Lipid Metabolism; Male; Mitochondria, Heart; Myocardial Infarction; Nicorandil; Oxidation-Reduction; Rats; Rats, Wistar; Succinic Acid | 2003 |
Nicorandil induces late preconditioning against myocardial infarction in conscious rabbits.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Cyclooxygenase 2; Gene Expression; Genes, bcl-2; Heart Rate; Ischemic Preconditioning, Myocardial; Isoenzymes; Male; Myocardial Infarction; Nicorandil; Prostaglandin-Endoperoxide Synthases; Rabbits | 2004 |
Effects of cariporide (HOE642) on myocardial infarct size and ventricular arrhythmias in a rat ischemia/reperfusion model: comparison with other drugs.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Dose-Response Relationship, Drug; Electrocardiography; Guanidines; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Nifedipine; Propranolol; Rats; Rats, Sprague-Dawley; Sulfones; Tachycardia, Ventricular | 2004 |
Effects of nicorandil on endogenous fibrinolytic capacity in patients with coronary artery disease.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Anti-Arrhythmia Agents; Calcium Channel Blockers; Coronary Artery Disease; Female; Fibrinolysis; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Plasminogen Activator Inhibitor 1; Tissue Plasminogen Activator | 2004 |
Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; ATP-Binding Cassette Transporters; Heart Ventricles; Male; Myocardial Infarction; Nicorandil; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors; Up-Regulation | 2004 |
Myocardial protection from either ischaemic preconditioning or nicorandil is not blocked by gliclazide.
Topics: Animals; Anti-Arrhythmia Agents; Gliclazide; Glyburide; Hypoglycemic Agents; Ischemic Preconditioning; Male; Membrane Potentials; Mitochondria, Heart; Myocardial Infarction; Nicorandil; Rats; Rats, Sprague-Dawley | 2004 |
Effect of combined intracoronary adenosine and nicorandil on no-reflow phenomenon during percutaneous coronary intervention.
Topics: Adenosine; Aged; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Treatment Outcome | 2004 |
[Cardioprotective effects of K(ATP) channel opener nicorandil during ischemia/ reperfusion in dogs].
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dogs; Female; Ischemic Preconditioning, Myocardial; KATP Channels; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Nicorandil; Random Allocation; Time Factors; Vasodilator Agents | 2005 |
[Beneficial effects of nicorandil on myocardial no-reflow state in a mini-swine model of acute myocardial infarction and reperfusion].
Topics: Animals; Coronary Vessels; Disease Models, Animal; Female; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Nicorandil; Random Allocation; Regional Blood Flow; Swine; Swine, Miniature | 2005 |
[Evolution of secondary prevention medication prescriptions after myocardial revascularisation: the ANCOR survey].
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Drug Utilization; Female; France; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Infarction; Myocardial Revascularization; Nicorandil; Platelet Aggregation Inhibitors; Postoperative Care; Practice Patterns, Physicians'; Preoperative Care; Secondary Prevention | 2005 |
Reduction of myocardial infarct size by SM-197378, a novel Na+/H+ exchange inhibitor, in rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart; Heart Rate; Indoles; Ischemic Preconditioning; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nicorandil; Rabbits; Sodium-Hydrogen Exchangers; Time Factors; Vasodilator Agents | 2005 |
Determinants of coronary events in patients with stable angina: results from the impact of nicorandil in angina study.
Topics: Aged; Angina Pectoris; Double-Blind Method; Female; Humans; Male; Middle Aged; Models, Statistical; Myocardial Infarction; Nicorandil; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Vasodilator Agents | 2005 |
Nicorandil reduces myocardial no-reflow by protection of endothelial function via the activation of KATP channel.
Topics: Animals; Antihypertensive Agents; Coronary Circulation; Endothelial Cells; Endothelium, Vascular; Glyburide; Myocardial Infarction; Nicorandil; Nitric Oxide Synthase; Organ Size; Potassium Channels; Swine; Swine, Miniature; Up-Regulation | 2006 |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.
Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GAP-43 Protein; Glyburide; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; KATP Channels; Ligation; Male; Myocardial Infarction; Myocardium; Neurofilament Proteins; Nicorandil; Norepinephrine; Pinacidil; Polymerase Chain Reaction; Potassium Channel Blockers; Pravastatin; Rats; Rats, Wistar; RNA, Messenger; Sympathetic Nervous System; Tachycardia, Ventricular; Time Factors; Tyrosine 3-Monooxygenase; Ventricular Fibrillation; Ventricular Remodeling | 2007 |
Intravenous nicorandil preserves endothelial junctions by decreasing endothelin-1 via activation of ATP-sensitive K+ channel.
Topics: Animals; Antigens, CD; Cadherins; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Endothelin-1; Glyburide; Injections, Intravenous; Intercellular Junctions; KATP Channels; Ligation; Myocardial Infarction; Myocardium; Nicorandil; No-Reflow Phenomenon; Potassium Channel Blockers; Research Design; Swine; Swine, Miniature; Vasodilator Agents | 2007 |
p38-MAPK is involved in restoration of the lost protection of preconditioning by nicorandil in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Cyclic GMP; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Nicorandil; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Potassium Channels; Protein Kinase C; Pyridines; Rabbits; Signal Transduction | 2008 |
Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts.
Topics: Animals; Glyburide; Hemodynamics; Hypertrophy, Left Ventricular; Immunohistochemistry; KATP Channels; Male; Muscle Cells; Myocardial Infarction; Nicorandil; Pinacidil; Rats; Rats, Wistar; Risk Factors; Time Factors; Ventricular Remodeling | 2008 |
SG-75 induction of increased coronary outflow and PGE1 from ischemic areas in dogs with experimental myocardial infarction.
Topics: Alprostadil; Animals; Coronary Circulation; Dinoprostone; Dogs; Indomethacin; Lactates; Myocardial Infarction; Myocardium; Niacinamide; Nicorandil; Prostaglandins E; Vasodilator Agents | 1982 |
Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog.
Topics: Adenosine; Animals; Cell Movement; Coronary Circulation; Dogs; Female; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Neutrophils; Niacinamide; Nicorandil; Nitroglycerin; Peroxidase; Regional Blood Flow; Vasodilator Agents | 1995 |
The ATP-regulated potassium channel in ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Dogs; Glyburide; Ion Channel Gating; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Picolines; Potassium Channels; Pyrans; Tolbutamide | 1994 |
Evaluation of the efficacy of nicorandil in patients with ischemic heart disease by exercise Tl-201 myocardial SPECT.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Antihypertensive Agents; Coronary Angiography; Coronary Artery Bypass; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Niacinamide; Nicorandil; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 1994 |
Anti-ischaemic actions of potassium channel openers in experimental myocardial ischaemia/reperfusion injury in dogs.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Picolines; Potassium; Potassium Channels; Pyrans; Vasodilator Agents | 1993 |
Safety profile of an anti-anginal agent with potassium channel opening activity: an overview.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Coronary Circulation; Drug Monitoring; Electrocardiography; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1993 |
Study of the efficacy of nicorandil in patients with ischaemic heart disease using Exercise-T1-201 myocardial tomography.
Topics: Adult; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Coronary Artery Bypass; Coronary Circulation; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Niacinamide; Nicorandil; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 1993 |
Limitation of myocardial infarct size by nicorandil after sustained ischemia in pigs.
Topics: Animals; Blood Pressure; Cardiac Output; Female; Glutathione; Heart Rate; Isosorbide Dinitrate; Male; Malondialdehyde; Myocardial Infarction; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Peroxidase; Potassium Channels; Pulmonary Wedge Pressure; Swine; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left | 1995 |
Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs.
Topics: Adenosine; Animals; Dogs; Female; Glyburide; Ion Channel Gating; Male; Methylene Blue; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Potassium Channels; Vasodilator Agents | 1996 |
Role of activation of ectosolic 5'-nucleotidase in the cardioprotection mediated by opening of K+c channels.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Enzyme Activation; Glyburide; Heart; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Recurrence | 1996 |
Disappearance of the 'no-reflow' phenomenon after adjunctive intracoronary administration of nicorandil in a patient with acute myocardial infarction.
Topics: Coronary Circulation; Coronary Vessels; Humans; Injections; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium Channels; Thrombolytic Therapy; Ultrasonography | 1997 |
Glibenclamide-induced blockade of ischemic preconditioning is time dependent in intact rat heart.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Glyburide; Heart; Hemodynamics; Hypotension; Ischemic Preconditioning; Male; Myocardial Infarction; Niacinamide; Nicorandil; Rats; Rats, Wistar; Time Factors | 1997 |
Ventricular fibrillation in preconditioned pig hearts: role of K+ATP channels.
Topics: Action Potentials; Animals; Blood Glucose; Blood Pressure; Glyburide; Heart; Heart Rate; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium Channel Blockers; Potassium Channels; Swine; Time Factors; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Myocardial protection afforded by nicorandil and ischaemic preconditioning in a rabbit infarct model in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Niacinamide; Nicorandil; Rabbits | 1998 |
Nicorandil reduces myocardial infarct size by opening the K(ATP) channel in rabbits.
Topics: Analysis of Variance; Animals; Blood Pressure; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Linear Models; Male; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rabbits; Time Factors; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Estimation of coronary flow reserve by intracoronary administration of nicorandil: comparison with intracoronary administration of papaverine.
Topics: Angina Pectoris; Coronary Angiography; Coronary Circulation; Coronary Vessels; Electrocardiography; Female; Humans; Male; Myocardial Infarction; Nicorandil; Papaverine; Vasodilator Agents | 1998 |
Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins.
Topics: Anesthetics, Inhalation; Animals; Dogs; GTP-Binding Proteins; Hemodynamics; Ischemic Preconditioning, Myocardial; Isoflurane; Myocardial Infarction; Nicorandil; Pertussis Toxin; Potassium Channels; Vasodilator Agents; Virulence Factors, Bordetella | 2000 |
[Coronary flow after successful angioplasty in patients with acute myocardial infarction: comparison between coronary flow reserve by nicorandil and papaverine].
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nicorandil; Papaverine; Ultrasonics; Vasodilator Agents | 2000 |
Reduction of myocardial infarct size by SM-20550, a novel Na(+)/H(+) exchange inhibitor, in rabbits.
Topics: Amidines; Animals; Anti-Arrhythmia Agents; Blood Pressure; Creatine Kinase; Disease Models, Animal; Heart Rate; Indoles; Male; Myocardial Infarction; Nicorandil; Protective Agents; Rabbits; Sodium-Hydrogen Exchangers | 2000 |
Cardioprotective effects of nicorandil in rabbits anaesthetized with halothane: potentiation of ischaemic preconditioning via KATP channels.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Body Weight; Decanoic Acids; Halothane; Heart; Heart Rate; Hemodynamics; Hydroxy Acids; Ischemic Preconditioning, Myocardial; KATP Channels; Magnetic Resonance Spectroscopy; Male; Myocardial Infarction; Nicorandil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Vasodilator Agents | 2000 |
Successful management of intractable coronary spasm with a coronary stent.
Topics: Adult; Amlodipine; Aspirin; Calcium Channel Blockers; Cardiovascular Agents; Coronary Angiography; Coronary Artery Disease; Coronary Vasospasm; Diltiazem; Doxazosin; Drug Resistance; Drug Therapy, Combination; Ergonovine; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Nicorandil; Nitrates; Pyridines; Stents; Ticlopidine; Ventricular Fibrillation | 2000 |
Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Collateral Circulation; Coronary Circulation; Cromakalim; Decanoic Acids; Diazoxide; Dogs; Heart; Hemodynamics; Hydroxy Acids; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Potassium Channel Blockers; Potassium Channels; Sarcolemma; Vasodilator Agents | 2001 |
Combination of miglitol, an anti-diabetic drug, and nicorandil markedly reduces myocardial infarct size through opening the mitochondrial K(ATP) channels in rabbits.
Topics: 1-Deoxynojirimycin; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glucosamine; Heart Rate; Hemodynamics; Hydroxy Acids; Hypoglycemic Agents; Imino Pyranoses; Male; Mitochondria, Heart; Myocardial Infarction; Nicorandil; Potassium Channels; Rabbits | 2001 |
Assessment of nicorandil therapy in ischemic myocardial injury by using contrast-enhanced and functional MR imaging.
Topics: Animals; Contrast Media; Echo-Planar Imaging; Gadolinium DTPA; Magnetic Resonance Imaging; Mesoporphyrins; Myocardial Infarction; Myocardial Ischemia; Myocardium; Nicorandil; Rats; Vasodilator Agents; Ventricular Function, Left | 2001 |
Cardiovascular news.
Topics: Acetanilides; Angina, Unstable; Anti-Arrhythmia Agents; Calcium Channel Blockers; Coronary Disease; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolytic Agents; Fondaparinux; Humans; Hydantoins; Imidazoles; Imidazolidines; Multicenter Studies as Topic; Myocardial Infarction; Nicorandil; Piperazines; Polysaccharides; Randomized Controlled Trials as Topic; Ranolazine; Treatment Outcome | 2001 |
Effect of an orally active Na+/H+ exchange inhibitor, SMP-300, on experimental angina and myocardial infarction models in rats.
Topics: Administration, Oral; Angina Pectoris; Animals; Azocines; Coronary Disease; Electrocardiography; Isoproterenol; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nicorandil; Nifedipine; Propranolol; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sodium-Hydrogen Exchangers; Vasodilator Agents; Vasopressins | 2002 |
Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Creatine Kinase; Drug Synergism; Isoproterenol; L-Lactate Dehydrogenase; Male; Mitochondria, Heart; Myocardial Infarction; Nicorandil; Rats; Rats, Wistar; Transaminases; Vasodilator Agents | 2002 |
Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressure; Decanoic Acids; Heart Rate; Hemodynamics; Hydroxy Acids; Male; Membrane Proteins; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicorandil; Potassium Channels; Rabbits; Severity of Illness Index | 2002 |
Blood pool contrast-enhanced MRI detects suppression of microvascular permeability in early postinfarction reperfusion after nicorandil therapy.
Topics: Animals; Capillary Permeability; Contrast Media; Dextrans; Ferrosoferric Oxide; Image Enhancement; Iron; Magnetic Resonance Imaging; Magnetite Nanoparticles; Microcirculation; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Oxides; Rats; Vasodilator Agents; Ventricular Function, Left | 2002 |
Nicorandil improves myocardial high-energy phosphates in postinfarction porcine hearts.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Coronary Circulation; Dose-Response Relationship, Drug; Energy Metabolism; Hemodynamics; Lactates; Magnetic Resonance Spectroscopy; Myocardial Infarction; Myocardium; Nicorandil; Oxygen Consumption; Phosphates; Swine | 2002 |
Cardioprotective effects of nicorandil.
Topics: Animals; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Female; Heart; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neutrophils; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion; Superoxides | 1992 |
Cardiovascular effects of the novel potassium channel opener bimakalim in conscious pigs after myocardial infarction: a comparative study with nicorandil.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Dihydropyridines; Hemodynamics; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channels; Propranolol; Swine; Vasodilation; Ventricular Function, Left | 1992 |
A new strategy for the reduction of acute myocardial infarction in variant angina.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris, Variant; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Coronary Angiography; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Nitroglycerin; Regression Analysis; Retrospective Studies; Vasodilator Agents | 1991 |
Effect of low grade exercise training and a vasodilator on cardiac function in patients with recent myocardial infarction.
Topics: Cardiac Output; Exercise Therapy; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Pulmonary Wedge Pressure; Vasodilator Agents; Ventricular Function, Left | 1990 |
Comparative effects of nicorandil, a nicotinamide nitrate derivative, and nifedipine on myocardial reperfusion injury in dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Dogs; Female; Male; Myocardial Contraction; Myocardial Infarction; Niacinamide; Nicorandil; Nifedipine | 1987 |
Effects of a new vasodilator, nicorandil, on exercise-induced impairment of left ventricular function in patients with old myocardial infarction.
Topics: Adult; Coronary Circulation; Exercise Test; Heart; Heart Ventricles; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Vasodilator Agents | 1987 |
Reduction of size of myocardial infarction with nicorandil, a new antianginal drug, after coronary artery occlusion in dogs.
Topics: Animals; Coronary Disease; Dogs; Female; Hemodynamics; Male; Myocardial Infarction; Niacinamide; Nicorandil; Vasodilator Agents | 1988 |