nicomorphine and Arrhythmias--Cardiac

One hundred and twenty-nine patients were subjected to three different types of thoracic operations. The patients were randomly allocated to balanced intravenous anaesthesia including i.v. nicomorphine during surgery and epidural nicomorphine post-operatively (epidural group, n = 58) or to balanced intravenous anaesthesia without i.v. opiates but with high thoracic epidural regional block during the operation and with post-operative intramuscular nicomorphine (intramuscular group, n = 71). Post-operative nicomorphine was only given at the request of the patients, and as frequently as needed to obtain satisfactory pain relief. Patients in the epidural group were given nicomorphine exclusively by epidural injection. Post-operatively, both groups (i.m. and epidural) obtained effective and rapid onset of analgesia, but the pain assessments by the patient and the medical team favoured the epidural group. The requirements of nicomorphine over a period of 3 days were significantly lower in the epidural group 42 mg (s.d. = 18) versus 92 mg (s.d. = 33) in the intramuscular group. Significantly fewer pulmonary complications were observed in the epidural group: 7 atelectases compared to 27 in the intramuscular group. The epidural group showed no signs of ventilatory depression in spite of a catheter inserted at the T3-T4 level.

Topics: Analgesia; Arrhythmias, Cardiac; Carbon Dioxide; Female; Humans; Injections, Epidural; Male; Middle Aged; Morphine Derivatives; Nicotinic Acids; Pain, Postoperative; Preanesthetic Medication; Thoracotomy

One hundred and sixty-three patients subjected to three different types of thoracic operation were allocated randomly either to balanced intravenous anaesthesia including i.v. opiates with post-operative intramuscular opiates (intramuscular group) or to balanced intravenous anaesthesia without i.v. opiates but with high thoracic epidural regional block during the operation as well as epidural nicomorphine post-operatively (epidural group). Post-operative nicomorphine in either group was given only at the request of the patient and as frequently as needed to obtain satisfactory pain relief. Patients in the epidural group were given nicomorphine exclusively by epidural injection. Patients in the epidural group required significantly less nicomorphine for effective pain relief (29 mg (sd = 10) over a period of 3 days compared to 52 mg (sd = 27) in the intramuscular group. Significantly fewer pulmonary complications in the epidural group were observed (9 atelectases in 83 patients in the epidural group compared to 24 atelectases in 80 patients in the intramuscular group). Only one patient developed pneumonia (intramuscular group). Although the epidural catheter was inserted at the T3-T4 level, no signs of ventilatory depression were found; on the contrary, respiration in the epidural group was significantly better than the intramuscular group. None of the patients, in either analgesia group, needed to be ventilated post-operatively.

Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Carbon Dioxide; Epidural Space; Female; Humans; Injections, Intramuscular; Lung Diseases, Obstructive; Male; Middle Aged; Morphine Derivatives; Nicotinic Acids; Pain, Postoperative; Postoperative Complications; Pulmonary Atelectasis; Respiration; Thoracic Surgery

Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Blood Pressure; Chest Pain; Electrocardiography; Female; Heart Failure; Heart Rate; Humans; Male; Middle Aged; Morphine Derivatives; Myocardial Infarction; Nicotinic Acids; Pain Measurement