Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Article | Year |
The anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression.Cell death & disease, 2022, 02-03, Volume: 13, Issue:2
Topics: Animals; Anthelmintics; beta Catenin; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Gemcitabi | 2022 |
The anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression.Cell death & disease, 2022, 02-03, Volume: 13, Issue:2
Topics: Animals; Anthelmintics; beta Catenin; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Gemcitabi | 2022 |
The anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression.Cell death & disease, 2022, 02-03, Volume: 13, Issue:2
Topics: Animals; Anthelmintics; beta Catenin; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Gemcitabi | 2022 |
The anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression.Cell death & disease, 2022, 02-03, Volume: 13, Issue:2
Topics: Animals; Anthelmintics; beta Catenin; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Gemcitabi | 2022 |
Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer.Cancer biology & therapy, 2023, 12-31, Volume: 24, Issue:1
Topics: Apoptosis; beta Catenin; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Gemcita | 2023 |
Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer.Cancer biology & therapy, 2023, 12-31, Volume: 24, Issue:1
Topics: Apoptosis; beta Catenin; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Gemcita | 2023 |
Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer.Cancer biology & therapy, 2023, 12-31, Volume: 24, Issue:1
Topics: Apoptosis; beta Catenin; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Gemcita | 2023 |
Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer.Cancer biology & therapy, 2023, 12-31, Volume: 24, Issue:1
Topics: Apoptosis; beta Catenin; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Gemcita | 2023 |