niclosamide has been researched along with Neuroblastoma in 4 studies
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we used a mitochondrial uncoupler, niclosamide ethanolamine (NEN), to activate mitochondrial respiration, which induced neural differentiation in neuroblastoma cells." | 4.31 | Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. ( Banuelos, S; Chiu, B; Forgo, B; Greathouse, RL; Gruber, JJ; He, B; Hu, Z; Jiang, H; Li, A; Li, AM; Li, Y; Rankin, EB; Shih, M; Shimada, H; Tiche, SJ; Ye, J; Yip, M; Zhao, M; Zhou, MN, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rank, L | 1 |
| Puhl, AC | 1 |
| Havener, TM | 1 |
| Anderson, E | 1 |
| Foil, DH | 1 |
| Zorn, KM | 1 |
| Monakhova, N | 1 |
| Riabova, O | 1 |
| Hickey, AJ | 1 |
| Makarov, V | 1 |
| Ekins, S | 1 |
| Jiang, H | 1 |
| Greathouse, RL | 1 |
| Tiche, SJ | 1 |
| Zhao, M | 1 |
| He, B | 1 |
| Li, Y | 1 |
| Li, AM | 1 |
| Forgo, B | 1 |
| Yip, M | 1 |
| Li, A | 1 |
| Shih, M | 1 |
| Banuelos, S | 1 |
| Zhou, MN | 1 |
| Gruber, JJ | 1 |
| Rankin, EB | 1 |
| Hu, Z | 1 |
| Shimada, H | 1 |
| Chiu, B | 1 |
| Ye, J | 1 |
| Byrne, FL | 1 |
| Bell, JL | 1 |
| Mito, S | 1 |
| Cheng, B | 1 |
| Garcia, BA | 1 |
| Yee Ooi, X | 1 |
| Gonzalez, D | 1 |
| Ruiz, TC | 1 |
| Elisarraras, FX | 1 |
| Tsin, A | 1 |
4 other studies available for niclosamide and Neuroblastoma
| Article | Year |
|---|---|
Multiple approaches to repurposing drugs for neuroblastoma.
Topics: Bayes Theorem; Cell Line, Tumor; Child; Child, Preschool; Crizotinib; Drug Repositioning; Etoposide; | 2022 |
Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma.
Topics: Animals; beta Catenin; Cell Differentiation; Cell Line, Tumor; Epigenome; Ethanolamine; Ethanolamine | 2023 |
Neuroblastoma Differentiation: The Untapped Potential of Mitochondrial Uncouplers.
Topics: Antineoplastic Agents; Cell Differentiation; Epigenome; Ethanolamine; Humans; Neuroblastoma; Niclosa | 2023 |
SAR study of niclosamide derivatives for neuroprotective function in SH-SY5Y neuroblastoma.
Topics: Apoptosis; Cell Line, Tumor; Humans; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agen | 2023 |