niclosamide has been researched along with Melanoma in 4 studies
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Niclosamide (NCL) is an FDA-approved anthelmintic drug and is reported to have strong anti-cancer properties against various solid and liquid tumors." | 5.91 | Niclosamide inhibits epithelial-mesenchymal transition with apoptosis induction in BRAF/ NRAS mutated metastatic melanoma cells. ( Godugu, C; Nagula, S; Pooladanda, V; Thatikonda, S; Tokala, R, 2023) |
| "Malignant melanoma is one of the most aggressive and lethal skin cancer." | 5.91 | Combination of niclosamide and quinacrine inactivates Akt/HK2/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation. ( Ding, C; Ge, X; Jiang, J; Li, S; Li, Y; Qiao, Y; Wang, D; Wang, M; Wang, Y; Zheng, X, 2023) |
| "Melanoma is the most malignant form of skin cancer across the globe." | 5.72 | Quality by design steered development of Niclosamide loaded liposomal thermogel for Melanoma: In vitro and Ex vivo evaluation. ( Bagasariya, D; Bala Singh, S; Charankumar, K; Famta, P; Fernandes, V; Kumar Khatri, D; Shah, S; Srivastava, S, 2022) |
| "Niclosamide (NCL) is an FDA-approved anthelmintic drug and is reported to have strong anti-cancer properties against various solid and liquid tumors." | 1.91 | Niclosamide inhibits epithelial-mesenchymal transition with apoptosis induction in BRAF/ NRAS mutated metastatic melanoma cells. ( Godugu, C; Nagula, S; Pooladanda, V; Thatikonda, S; Tokala, R, 2023) |
| "Malignant melanoma is one of the most aggressive and lethal skin cancer." | 1.91 | Combination of niclosamide and quinacrine inactivates Akt/HK2/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation. ( Ding, C; Ge, X; Jiang, J; Li, S; Li, Y; Qiao, Y; Wang, D; Wang, M; Wang, Y; Zheng, X, 2023) |
| "Melanoma is the most malignant form of skin cancer across the globe." | 1.72 | Quality by design steered development of Niclosamide loaded liposomal thermogel for Melanoma: In vitro and Ex vivo evaluation. ( Bagasariya, D; Bala Singh, S; Charankumar, K; Famta, P; Fernandes, V; Kumar Khatri, D; Shah, S; Srivastava, S, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shah, S | 1 |
| Famta, P | 1 |
| Fernandes, V | 1 |
| Bagasariya, D | 1 |
| Charankumar, K | 1 |
| Kumar Khatri, D | 1 |
| Bala Singh, S | 1 |
| Srivastava, S | 1 |
| Thatikonda, S | 1 |
| Pooladanda, V | 1 |
| Tokala, R | 1 |
| Nagula, S | 1 |
| Godugu, C | 1 |
| Li, S | 1 |
| Wang, D | 1 |
| Zheng, X | 1 |
| Li, Y | 1 |
| Ding, C | 1 |
| Wang, M | 1 |
| Ge, X | 1 |
| Jiang, J | 1 |
| Qiao, Y | 1 |
| Wang, Y | 1 |
| Zhou, J | 1 |
| Jin, B | 1 |
| Jin, Y | 1 |
| Liu, Y | 1 |
| Pan, J | 1 |
4 other studies available for niclosamide and Melanoma
| Article | Year |
|---|---|
Quality by design steered development of Niclosamide loaded liposomal thermogel for Melanoma: In vitro and Ex vivo evaluation.
Topics: Administration, Cutaneous; Humans; Liposomes; Melanoma; Niclosamide; Skin Neoplasms; Tumor Microenvi | 2022 |
Niclosamide inhibits epithelial-mesenchymal transition with apoptosis induction in BRAF/ NRAS mutated metastatic melanoma cells.
Topics: Apoptosis; Cell Line, Tumor; Epithelial-Mesenchymal Transition; GTP Phosphohydrolases; Humans; Melan | 2023 |
Combination of niclosamide and quinacrine inactivates Akt/HK2/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation.
Topics: Cell Line, Tumor; Cell Proliferation; Cyclin D1; Glucose; Humans; Melanoma; Niclosamide; Proto-Oncog | 2023 |
The antihelminthic drug niclosamide effectively inhibits the malignant phenotypes of uveal melanoma
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dise | 2017 |