niclosamide has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 3 studies
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, B | 2 |
| Wang, C | 2 |
| Shen, Y | 1 |
| Pan, J | 2 |
| Li, J | 1 |
| Du, X | 1 |
| Ding, K | 1 |
| Liu, Z | 1 |
| Li, Y | 1 |
| Lv, C | 1 |
| Wang, L | 1 |
| Song, H | 1 |
3 other studies available for niclosamide and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant.
Topics: Animals; Anthelmintics; Apoptosis; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; F | 2018 |
Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia.
Topics: Animals; Anthelmintics; Antineoplastic Agents; Apoptosis; beta Catenin; Cell Self Renewal; Chromatin | 2017 |
Anthelmintic drug niclosamide enhances the sensitivity of chronic myeloid leukemia cells to dasatinib through inhibiting Erk/Mnk1/eIF4E pathway.
Topics: Anthelmintics; Antigens, CD34; Apoptosis; Cell Line, Tumor; Cell Self Renewal; Dasatinib; Drug Syner | 2016 |