niclosamide has been researched along with Inflammation in 11 studies
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Importantly, niclosamide in vivo treatment of ALS-FUS mice reduces the expression of S100A4, α-SMA, and PDGFRβ in the spinal cord, as well as gliosis in central and peripheral nervous tissues, together with axonal impairment and displays beneficial effects on muscle atrophy, by promoting muscle regeneration and reducing fibrosis." | 8.02 | Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis. ( Apolloni, S; Cozzolino, M; D'Ambrosi, N; Lattante, S; Mammarella, E; Miele, C; Milani, M; Rossi, S; Sabatelli, M, 2021) |
| "This study evaluated the anti-inflammatory effect of niclosamide in tumor necrosis factor (TNF)-α-stimulated human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) and inhibitory effects on migration and invasion in RA FLS and investigated the signal mechanism, and further explored the treatment activity of niclosamide on collagen-induced arthritis (CIA)." | 7.81 | Inhibitory effects of niclosamide on inflammation and migration of fibroblast-like synoviocytes from patients with rheumatoid arthritis. ( Huang, M; Lao, M; Liang, L; Shi, M; Xiao, Y; Xu, H; Yang, X; Zen, S; Zou, Y, 2015) |
| "Psoriasis is an autoimmune skin disease, where hyperproliferation of keratinocytes and exaggerated immune responses are the important hallmarks of the disease." | 5.56 | Repurposing an old drug for new use: Niclosamide in psoriasis-like skin inflammation. ( Godugu, C; Pooladanda, V; Thatikonda, S, 2020) |
| "Niclosamide is an efficacious and FDA-approved drug for the treatment of helminthosis in humans that has been used for decades." | 5.56 | Niclosamide suppresses macrophage-induced inflammation in endometriosis†. ( de Mola, JRL; Diaz-Sylvester, P; Groesch, K; Hayashi, K; Hirota, Y; MacLean, JA; Sekulovski, N; Shi, M; Tanaka, T; Whorton, AE; Wilson, T, 2020) |
| " Importantly, niclosamide in vivo treatment of ALS-FUS mice reduces the expression of S100A4, α-SMA, and PDGFRβ in the spinal cord, as well as gliosis in central and peripheral nervous tissues, together with axonal impairment and displays beneficial effects on muscle atrophy, by promoting muscle regeneration and reducing fibrosis." | 4.02 | Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis. ( Apolloni, S; Cozzolino, M; D'Ambrosi, N; Lattante, S; Mammarella, E; Miele, C; Milani, M; Rossi, S; Sabatelli, M, 2021) |
| "This study evaluated the anti-inflammatory effect of niclosamide in tumor necrosis factor (TNF)-α-stimulated human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) and inhibitory effects on migration and invasion in RA FLS and investigated the signal mechanism, and further explored the treatment activity of niclosamide on collagen-induced arthritis (CIA)." | 3.81 | Inhibitory effects of niclosamide on inflammation and migration of fibroblast-like synoviocytes from patients with rheumatoid arthritis. ( Huang, M; Lao, M; Liang, L; Shi, M; Xiao, Y; Xu, H; Yang, X; Zen, S; Zou, Y, 2015) |
| "Psoriasis is an autoimmune skin disease, where hyperproliferation of keratinocytes and exaggerated immune responses are the important hallmarks of the disease." | 1.56 | Repurposing an old drug for new use: Niclosamide in psoriasis-like skin inflammation. ( Godugu, C; Pooladanda, V; Thatikonda, S, 2020) |
| "Niclosamide is an efficacious and FDA-approved drug for the treatment of helminthosis in humans that has been used for decades." | 1.56 | Niclosamide suppresses macrophage-induced inflammation in endometriosis†. ( de Mola, JRL; Diaz-Sylvester, P; Groesch, K; Hayashi, K; Hirota, Y; MacLean, JA; Sekulovski, N; Shi, M; Tanaka, T; Whorton, AE; Wilson, T, 2020) |
| "Hepatocellular carcinoma was then developed in the transgenic zebrafish." | 1.42 | Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. ( Choi, JH; Chung, YY; Jung, IH; Lim, GL; Park, SW; Park, YN, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 6 (54.55) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Xu, J | 1 |
| Wu, W | 1 |
| Chen, H | 1 |
| Xue, Y | 1 |
| Bao, X | 1 |
| Zhou, J | 1 |
| Thatikonda, S | 1 |
| Pooladanda, V | 1 |
| Godugu, C | 1 |
| Sekulovski, N | 3 |
| Whorton, AE | 3 |
| Tanaka, T | 1 |
| Hirota, Y | 1 |
| Shi, M | 4 |
| MacLean, JA | 3 |
| de Mola, JRL | 1 |
| Groesch, K | 1 |
| Diaz-Sylvester, P | 1 |
| Wilson, T | 1 |
| Hayashi, K | 3 |
| Pan, X | 1 |
| Song, Y | 1 |
| He, M | 1 |
| Yan, X | 1 |
| Huang, C | 1 |
| Li, J | 1 |
| Dong, W | 1 |
| Cheng, J | 1 |
| Jia, J | 1 |
| Greaves, E | 1 |
| Milani, M | 1 |
| Mammarella, E | 1 |
| Rossi, S | 1 |
| Miele, C | 1 |
| Lattante, S | 1 |
| Sabatelli, M | 1 |
| Cozzolino, M | 1 |
| D'Ambrosi, N | 1 |
| Apolloni, S | 1 |
| Liang, L | 1 |
| Huang, M | 1 |
| Xiao, Y | 1 |
| Zen, S | 1 |
| Lao, M | 1 |
| Zou, Y | 1 |
| Yang, X | 1 |
| Xu, H | 1 |
| Jung, IH | 1 |
| Choi, JH | 1 |
| Chung, YY | 1 |
| Lim, GL | 1 |
| Park, YN | 1 |
| Park, SW | 1 |
| Navab, M | 1 |
| Ruchala, P | 1 |
| Waring, AJ | 1 |
| Lehrer, RI | 1 |
| Hama, S | 1 |
| Hough, G | 1 |
| Palgunachari, MN | 1 |
| Anantharamaiah, GM | 1 |
| Fogelman, AM | 1 |
11 other studies available for niclosamide and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Substituted N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide analogues potently inhibit respiratory syncytial virus (RSV) replication and RSV infection-associated inflammatory responses.
Topics: A549 Cells; Antiviral Agents; Benzamides; Humans; Inflammation; Respiratory Syncytial Virus Infectio | 2021 |
Repurposing an old drug for new use: Niclosamide in psoriasis-like skin inflammation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Drug Repositioning; Humans; Inflammation; Keratinocyte | 2020 |
Niclosamide suppresses macrophage-induced inflammation in endometriosis†.
Topics: Animals; Anticestodal Agents; Cell Survival; Cells, Cultured; Endometriosis; Female; Gene Expression | 2020 |
Mitochondrial Uncouplers Confer Protection by Activating AMP-Activated Protein Kinase to Inhibit Neuroinflammation Following Intracerebral Hemorrhage.
Topics: AMP-Activated Protein Kinases; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, C | 2020 |
Efficacy of niclosamide on the intra-abdominal inflammatory environment in endometriosis.
Topics: Animals; Anticestodal Agents; Endometriosis; Female; Ganglia, Spinal; GATA6 Transcription Factor; In | 2021 |
Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Disease Models, Animal; Fibro | 2021 |
Endometriotic inflammatory microenvironment induced by macrophages can be targeted by niclosamide†.
Topics: Anticestodal Agents; Cell Communication; Cell Line; Cell Survival; Down-Regulation; Endometritis; Ep | 2019 |
Inhibitory effects of niclosamide on inflammation and migration of fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Topics: Animals; Anticestodal Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Movement; Cells, | 2015 |
Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.
Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclic S-Oxides | 2015 |
A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Ap | 2009 |