niclosamide and Hymenolepiasis studies

Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.

Research Excerpts

Excerpt	Relevance	Reference
" Within several days posttreatment, destrobilated worms can regenerate to a size that is readily apparent in the gut contents, allowing the effective dosage to be determined with much greater confidence."	1.28	Anthelmintic-induced destrobilation and its influence on calculated drug efficacy in Hymenolepis diminuta infections in rats. ( Arai, HP; Dixon, BR, 1991)
"1980) for mass eradication of hymenolepiasis from rat colonies was assessed in a pilot study."	1.27	3,5-dibromo-2'-chloro-4'-isothiocyanato salicylanilide in the control of Hymenolepis nana in rats--a pilot study. ( Gupta, S; Katiyar, JC; Sen, AB; Sharma, S, 1984)
"Praziquantel was most effective in vivo, but had little action on adult worms and cysticercoids in vitro."	1.27	Comparative activity of anticestode drugs--praziquantel, niclosamide and Compound 77-6, against Hymenolepis nana. ( Gupta, S; Katiyar, JC, 1983)
" diminuta were cured with a second course of drug without changing the dosage or time schedule."	1.26	Niclosamide as a treatment for Hymenolepis diminuta and Dipylidium caninum infection in man. ( Jones, WE, 1979)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (85.71)	18.7374
1990's	3 (6.12)	18.2507
2000's	2 (4.08)	29.6817
2010's	2 (4.08)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Dubey, SK	2
Singh, AK	3
Singh, H	4
Sharma, S	4
Iyer, RN	4
Katiyar, JC	5
Goel, P	1
Sen, AB	4
Srivastava, OP	1
Kılınçel, Ö	1
Öztürk, CE	1
Gün, E	1
Öksüz, Ş	1
Uzun, H	1
Şahin, İ	1
Kılıç, N	1
Patamia, I	1
Cappello, E	1
Castellano-Chiodo, D	1
Greco, F	1
Nigro, L	1
Cacopardo, B	1
Marangi, M	1
Zechini, B	1
Fileti, A	1
Quaranta, G	1
Aceti, A	1
RICCI, M	1
MAZZETTIDIPIETRALATA, M	1
EDELWEISS, E	1
VIEIRA, L	1
NAGATY, HF	1
RIFAAT, MA	1
SALEM, S	1
Ostlind, DA	1
Mickle, WG	1
Smith, SK	1
Cifelli, S	1
Ewanciw, DV	1
Gupta, S	4
Martynenko, VB	1
Isaeva, KhB	2
Magdieva, SR	1
Ziganshina, NKh	2
Nasyrova, RM	2
Radaeva, RT	1
Cavier, R	1
Rossignol, JF	1
Sobota, K	1
Husárová, M	1
Sobotová, O	1
Reyes, H	1
Muñoz, V	1
Hernández, J	1
Molina, H	1
Ottolenghi, A	3
Larsh, JE	1
Weatherly, NF	1
Weisse, ME	1
Raszka, WV	1
Al-Hussaini, MK	1
Khalifa, R	1
Al-Ansary, AT	1
Hussain, GH	1
Moustafa, KM	1
Jones, WE	1
Chitchang, S	2
Sooksala, N	1
Radomyos, P	2
Cohen, R	1
Mackey, K	1
Sharma, HS	1
Barrett-Connor, E	1
Zychowicz, C	1
Kostkiewicz, M	1
Kowalczyk, S	1
Thomas, H	1
Rowland, JT	1
Turton, JA	1
Williamson, JR	1
Harris, WG	1
Dixon, BR	1
Arai, HP	1
Akhtar, MS	1
Riffat, S	1
Cohen, IP	1
el-Ridi, AM	1
el-Gamal, RL	1
Farghaly, AM	1
Nada, SM	1
Levi, MH	1
Raucher, BG	1
Teicher, E	1
Sheehan, DJ	1
McKitrick, JC	1
Zubitskaia, MA	1
Vasil'eva, NM	1
Piamjinda, T	1
Yodmani, B	1
Gönnert, R	1
Hughes, HC	1
Barthel, CH	1
Lang, CM	1
El-Masry, NA	1
Farid, Z	1
Bassily, S	1
Ghadirian, E	1
Arfaa, F	1
Gitter, M	1
Evans, G	1
Luckhurst, J	1
Cheah, JS	1
Kan, SP	1
Brkić, D	1
Glisić, L	1
Simić, P	1
Perera, DR	1
Western, KA	1
Schultz, MG	1
Ahkami, S	1
Hajian, A	1
Most, H	1
Yoeli, M	1
Hammond, J	1
Scheinesson, GP	1

Article	Year
Cestode infection in children. Advances in pediatric infectious diseases, 1996, Volume: 12 Topics: Adolescent; Albendazole; Animals; Anthelmintics; Anticestodal Agents; Antiplatyhelmintic Agents; Ces	1996
Recent advances in the treatment of common intestinal helminths. The American journal of gastroenterology, 1975, Volume: 63, Issue:2 Topics: Anthelmintics; Ascariasis; Cestode Infections; Dichlorvos; Fascioliasis; Helminthiasis; Hookworm Inf	1975

Article	Year
Synthesis of substituted 1-hydroxy-2-naphthanilides as potential cestodicidal agents. Journal of medicinal chemistry, 1978, Volume: 21, Issue:11 Topics: Anilides; Animals; Anticestodal Agents; Dogs; Hymenolepiasis; Naphthalenes; Rats; Structure-Activity	1978
Synthesis of 5-chloro-3'-nitro-4'-substituted salicylanilides, a new series of anthelmintic and antimicrobial agents. Journal of medicinal chemistry, 1977, Volume: 20, Issue:6 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anticestodal Agents; Bacteria; Fungi; Hymenol	1977
[A rare case of Hymenolepis diminuta infection in a small child]. Mikrobiyoloji bulteni, 2015, Volume: 49, Issue:1 Topics: Administration, Oral; Anemia, Iron-Deficiency; Animals; Anticestodal Agents; Diarrhea; Eating; Feces	2015
A human case of Hymenolepis diminuta in a child from eastern Sicily. The Korean journal of parasitology, 2010, Volume: 48, Issue:2 Topics: Animals; Anthelmintics; Child, Preschool; Feces; Humans; Hymenolepiasis; Hymenolepis diminuta; Hyper	2010
Hymenolepis diminuta infection in a child living in the urban area of Rome, Italy. Journal of clinical microbiology, 2003, Volume: 41, Issue:8 Topics: Animals; Anthelmintics; Child, Preschool; Feces; Humans; Hymenolepiasis; Hymenolepis; Italy; Male; N	2003
[ON THE TREATMENT OF HYMENOLEPIASIS WITH N-(2'-CHLORO-4'-NITROPHENYL)-5-CHLOROSALICYLAMIDE (YOMESAN)]. Rendiconti - Istituto superiore di sanita, 1963, Volume: 26 Topics: Anthelmintics; Cestode Infections; Hymenolepiasis; Niclosamide; Salicylamides	1963
[NOTES ON THE CYCLIC USE OF "YOMESAN" IN HYMENOLEPIS NANA INFECTION]. Wiadomosci parazytologiczne, 1963, Volume: 9 Topics: Animals; Anthelmintics; Cestode Infections; Humans; Hymenolepiasis; Hymenolepis nana; Niclosamide; S	1963
[TREATMENT OF HYMENOLEPIASIS WITH A SALICYLAMIDE DERIVATIVE]. Revista brasileira de medicina, 1965, Volume: 22 Topics: Cestode Infections; Drug Therapy; Hymenolepiasis; Niclosamide; Salicylamides; Toxicology	1965
Clinical trials with 'yomesan' in Hymenolepis nana infection. The Journal of tropical medicine and hygiene, 1962, Volume: 65 Topics: Animals; Anthelmintics; Cestode Infections; Hymenolepiasis; Hymenolepis nana; Niclosamide; Salicylam	1962
The Hymenolepis diminuta-golden hamster (Mesocricetus auratus) model for the evaluation of gastrointestinal anticestode activity. The Journal of parasitology, 2004, Volume: 90, Issue:4 Topics: Administration, Oral; Amidines; Animals; Anticestodal Agents; Cambendazole; Cricetinae; Digestive Sy	2004
3,5-dibromo-2'-chloro-4'-isothiocyanato salicylanilide in the control of Hymenolepis nana in rats--a pilot study. Journal of helminthology, 1984, Volume: 58, Issue:1 Topics: Animals; Animals, Laboratory; Female; Hymenolepiasis; Male; Mebendazole; Niclosamide; Pilot Projects	1984
Comparative activity of anticestode drugs--praziquantel, niclosamide and Compound 77-6, against Hymenolepis nana. Journal of helminthology, 1983, Volume: 57, Issue:1 Topics: Animals; Drug Evaluation, Preclinical; Hymenolepiasis; Hymenolepis; Isoquinolines; Male; Mice; Niclo	1983
[Hymenolepiasis]. Fel'dsher i akusherka, 1982, Volume: 47, Issue:3 Topics: Adolescent; Adult; Anthelmintics; Child; Child, Preschool; Humans; Hymenolepiasis; Niclosamide; Time	1982
[Effectiveness and tolerance of a 6-day course of fenasal treatment in hymenolepiasis in children]. Pediatriia, 1982, Issue:11 Topics: Adolescent; Anticestodal Agents; Child; Drug Evaluation; Drug Tolerance; Female; Humans; Hymenolepia	1982
[Comparative study of the tenicidal properties of albendazole, mebendazole, niclosamide and praziquantel in experimentally infested mice]. Annales pharmaceutiques francaises, 1982, Volume: 40, Issue:4 Topics: Albendazole; Animals; Anthelmintics; Benzimidazoles; Hymenolepiasis; Mebendazole; Mice; Niclosamide;	1982
Effect of mode of infection on the development and chemotherapeutic response of Hymenolepis nana in rats. Journal of helminthology, 1981, Volume: 55, Issue:2 Topics: Animals; Anticestodal Agents; Female; Hymenolepiasis; Hymenolepis; Isoquinolines; Male; Niclosamide;	1981
Anticestode activity of 3,5-dibromo-2'-chlorosalicylanilide-4'-isothiocyanate--a preliminary report. Journal of helminthology, 1980, Volume: 54, Issue:4 Topics: Animals; Anticestodal Agents; Drug Evaluation, Preclinical; Hymenolepiasis; Hymenolepis; Male; Mice;	1980
[Management of two cases of repeatedly unsuccessfully treated hymenolepiasis (author's transl)]. Bratislavske lekarske listy, 1981, Volume: 75, Issue:4 Topics: Adult; Humans; Hymenolepiasis; Intestinal Diseases, Parasitic; Male; Niclosamide	1981
[Two unusual cases of human infection with Taenia solium (author's transl)]. Revista medica de Chile, 1981, Volume: 109, Issue:11 Topics: Adult; Chile; Feces; Female; Humans; Hymenolepiasis; Niclosamide; Taenia; Taeniasis	1981
Phospholipase B levels in fecal pellets from mice infected with Trichinella spiralis, Hymenolepis nana, and Schistosoma mansoni. The American journal of tropical medicine and hygiene, 1980, Volume: 29, Issue:3 Topics: Animals; Feces; Hymenolepiasis; Lysophospholipase; Male; Mice; Niclosamide; Niridazole; Phospholipas	1980
Phlyctenular eye disease in association with Hymenolepis nana in Egypt. The British journal of ophthalmology, 1979, Volume: 63, Issue:9 Topics: Adolescent; Adult; Child; Child, Preschool; Egypt; Female; Humans; Hymenolepiasis; Infant; Keratocon	1979
Niclosamide as a treatment for Hymenolepis diminuta and Dipylidium caninum infection in man. The American journal of tropical medicine and hygiene, 1979, Volume: 28, Issue:2 Topics: Adolescent; Adult; Cestode Infections; Humans; Hymenolepiasis; Niclosamide	1979
A case report of Hymenolepis diminuta in Bangkok, Thailand. The Southeast Asian journal of tropical medicine and public health, 1978, Volume: 9, Issue:4 Topics: Female; Humans; Hymenolepiasis; Infant; Magnesium Sulfate; Niclosamide	1978
Hymenolepis diminuta unresponsive to quinacrine. The Western journal of medicine, 1977, Volume: 127, Issue:4 Topics: Child; Female; Humans; Hymenolepiasis; Niclosamide; Quinacrine	1977
5-chloro-3'-nitro-4'-cyclohexylaminosalicylanilide: a new cestodicidal agent. Indian journal of experimental biology, 1976, Volume: 14, Issue:3 Topics: Animals; Hymenolepiasis; Niclosamide; Rats	1976
[Therapeutic results in an endemic focus of dwarf tapeworm]. Przeglad epidemiologiczny, 1975, Volume: 29, Issue:2 Topics: Child, Preschool; Disease Outbreaks; Follow-Up Studies; Humans; Hymenolepiasis; Infant; Niclosamide	1975
[Reinfection and recidive in Hymenolepis nana infections (author's transl)]. Zeitschrift fur Parasitenkunde (Berlin, Germany), 1975, Volume: 46, Issue:1 Topics: Animals; Feces; Hymenolepiasis; Male; Mice; Mice, Inbred Strains; Niclosamide; Parasite Egg Count; R	1975
An enzymatic method (phospholipase B) for studies on cestode infection (Hymenolepis nana) and its suppression by chemotherapy. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 194, Issue:2 Topics: Animals; Clinical Enzyme Tests; Hymenolepiasis; Intestine, Small; Male; Mice; Niclosamide; Phospholi	1975
Haematological and immunological responses to the tapeworm hymenolepis diminuta in man. Tropenmedizin und Parasitologie, 1975, Volume: 26, Issue:2 Topics: Adult; Blood Viscosity; Eosinophilia; Erythrocyte Count; Hematocrit; Hemoglobins; Human Experimentat	1975
Anthelmintic-induced destrobilation and its influence on calculated drug efficacy in Hymenolepis diminuta infections in rats. The Journal of parasitology, 1991, Volume: 77, Issue:5 Topics: Animals; Feces; Hymenolepiasis; Hymenolepis; Male; Niclosamide; Praziquantel; Rats; Rats, Inbred Str	1991
Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. JPMA. The Journal of the Pakistan Medical Association, 1991, Volume: 41, Issue:8 Topics: Anticestodal Agents; Antinematodal Agents; Ascaridiasis; Child; Feces; Humans; Hymenolepiasis; Medic	1991
A case report of a Hymenolepis diminuta infection in a child in St James Parish, Jamaica. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1989, Volume: 141, Issue:3 Topics: Feces; Female; Humans; Hymenolepiasis; Infant; Intestinal Diseases, Parasitic; Jamaica; Niclosamide	1989
Effect of some anthelmintics on Hymenolepis nana in albino mice. Journal of the Egyptian Society of Parasitology, 1989, Volume: 19, Issue:2 Topics: Animals; Emetine; Female; Hymenolepiasis; Male; Mebendazole; Mice; Niclosamide	1989
Hymenolepis diminuta: one of three enteric pathogens isolated from a child. Diagnostic microbiology and infectious disease, 1987, Volume: 7, Issue:4 Topics: Campylobacter Infections; Child, Preschool; Furazolidone; Giardiasis; Humans; Hymenolepiasis; Niclos	1987
[Problem of the rational approach to the treatment of hymenolepiasis]. Pediatriia, 1987, Issue:8 Topics: Adolescent; Anticestodal Agents; Child; Child, Preschool; Female; Humans; Hymenolepiasis; Infant; Ma	1987
Relationship between severity of the symptom and the number of Hymenolepis nana after treatment. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1985, Volume: 68, Issue:8 Topics: Child, Preschool; Female; Humans; Hymenolepiasis; Hymenolepis; Male; Niclosamide; Parasite Egg Count	1985
[Tape worm infections of man and their therapy (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1974, Sep-06, Volume: 116, Issue:36 Topics: Africa; Asia; Australia; Cestode Infections; Chemical Phenomena; Chemistry; Cysticercosis; Diagnosis	1974
Niclosamide as a treatment for Hymenolepis nana and Hymenolepis diminuta in rats. Laboratory animal science, 1973, Volume: 23, Issue:1 Topics: Administration, Oral; Animals; Cestoda; Hymenolepiasis; Niclosamide; Rats; Rodent Diseases	1973
Human infection with Hymenolepis diminuta in villages of Minab, southern Iran. International journal for parasitology, 1972, Volume: 2, Issue:4 Topics: Aged; Child; Female; Humans; Hymenolepiasis; Iran; Male; Niclosamide	1972
High phospholipase content of intestines of mice infected with Hymenolepis nana. Lipids, 1973, Volume: 8, Issue:7 Topics: Animals; Cestoda; Dexamethasone; Female; Hymenolepiasis; Intestinal Diseases, Parasitic; Intestine,	1973
An outbreak of Hymenolepis infection in artificially reared mallard ducks. The Veterinary record, 1974, Apr-06, Volume: 94, Issue:14 Topics: Animal Feed; Animals; Autopsy; Bird Diseases; Disease Outbreaks; Ducks; Hymenolepiasis; Niclosamide	1974
A case of Hymenolepis nana infestation in Singapore responding to niclosamide. The Journal of tropical medicine and hygiene, 1971, Volume: 74, Issue:12 Topics: Adult; Anthelmintics; Humans; Hymenolepiasis; Male; Niclosamide; Salicylamides; Singapore	1971
[Yomesan in therapy of taeniasis and Hymenolepis nanae]. Medicinski glasnik, 1968, Volume: 22, Issue:4 Topics: Adolescent; Adult; Anthelmintics; Child; Child, Preschool; Female; Humans; Hymenolepiasis; Infant; I	1968
Niclosamide treatment of cestodiasis. Clinicial trials in the United States. The American journal of tropical medicine and hygiene, 1970, Volume: 19, Issue:4 Topics: Anthelmintics; Cestode Infections; Diphyllobothriasis; Diphyllobothrium; Feces; Follow-Up Studies; H	1970
Radical treatment of Hymenolepis nana with niclosamide. The Journal of tropical medicine and hygiene, 1970, Volume: 73, Issue:10 Topics: Adult; Anthelmintics; Cathartics; Child; Child, Preschool; Humans; Hymenolepiasis; Niclosamide; Rura	1970
Yomesan (niclosamide) therapy of Hymenolepis nana infections. The American journal of tropical medicine and hygiene, 1971, Volume: 20, Issue:2 Topics: Adolescent; Anthelmintics; Cestoda; Child; Child, Preschool; Feces; Humans; Hymenolepiasis; Intellec	1971

niclosamide and Hymenolepiasis

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