niclosamide has been researched along with ER-Negative PR-Negative HER2-Negative Breast Cancer in 7 studies
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Triple-negative breast cancer (TNBC) is one of the most difficult breast cancers to treat because there is no targeted treatment, and conventional cytotoxic chemotherapy followed by adjuvant radiation therapy is the standard of care for patients with TNBC." | 5.43 | Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/β-catenin signaling. ( Chen, H; Ding, D; Gao, Y; Wang, J; Yin, L; Zhang, J; Zhang, X; Zhang, Y, 2016) |
| "Triple-negative breast cancer (TNBC) is one of the most difficult breast cancers to treat because there is no targeted treatment, and conventional cytotoxic chemotherapy followed by adjuvant radiation therapy is the standard of care for patients with TNBC." | 1.43 | Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/β-catenin signaling. ( Chen, H; Ding, D; Gao, Y; Wang, J; Yin, L; Zhang, J; Zhang, X; Zhang, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, J | 2 |
| Kim, H | 2 |
| Dong, J | 2 |
| Chen, H | 2 |
| Ma, R | 1 |
| Zhou, M | 1 |
| Wang, T | 1 |
| Shen, Q | 2 |
| Zhou, J | 1 |
| Zhao, D | 1 |
| Hu, C | 1 |
| Fu, Q | 1 |
| Lv, H | 1 |
| Cámara-Sánchez, P | 1 |
| Díaz-Riascos, ZV | 1 |
| García-Aranda, N | 1 |
| Gener, P | 1 |
| Seras-Franzoso, J | 1 |
| Giani-Alonso, M | 1 |
| Royo, M | 1 |
| Vázquez, E | 1 |
| Schwartz, S | 1 |
| Abasolo, I | 1 |
| Lu, L | 1 |
| Wang, L | 1 |
| Xia, Q | 1 |
| Zhang, D | 1 |
| Yin, T | 1 |
| Fan, S | 1 |
| Pindiprolu, SKSS | 1 |
| Chintamaneni, PK | 1 |
| Krishnamurthy, PT | 1 |
| Ratna Sree Ganapathineedi, K | 1 |
| Liu, J | 1 |
| Chen, X | 1 |
| Ward, T | 1 |
| Pegram, M | 1 |
| Shen, K | 1 |
| Yin, L | 1 |
| Gao, Y | 1 |
| Zhang, X | 1 |
| Wang, J | 1 |
| Ding, D | 1 |
| Zhang, Y | 1 |
| Zhang, J | 1 |
7 other studies available for niclosamide and ER-Negative PR-Negative HER2-Negative Breast Cancer
| Article | Year |
|---|---|
Structure-activity relationship studies on O-alkylamino-tethered salicylamide derivatives with various amino acid linkers as potent anticancer agents.
Topics: Amino Acids; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; | 2022 |
Combined chemotherapy for triple negative breast cancer treatment by paclitaxel and niclosamide nanocrystals loaded thermosensitive hydrogel.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Humans; Hydrogels; Nanoparticles; Niclosamide; | 2021 |
Selectively Targeting Breast Cancer Stem Cells by 8-Quinolinol and Niclosamide.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Humans; Mice; Neoplastic Stem Cells; Niclosamide; Oxy | 2022 |
Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide.
Topics: Animals; Cell Line, Tumor; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Niclosamide; Proto | 2018 |
Formulation-optimization of solid lipid nanocarrier system of STAT3 inhibitor to improve its activity in triple negative breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug C | 2019 |
Combined niclosamide with cisplatin inhibits epithelial-mesenchymal transition and tumor growth in cisplatin-resistant triple-negative breast cancer.
Topics: Animals; Anticestodal Agents; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Movement; Ce | 2016 |
Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/β-catenin signaling.
Topics: Animals; Apoptosis; beta Catenin; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Hu | 2016 |