Page last updated: 2024-11-01

niclosamide and Diabetes Mellitus, Type 2

niclosamide has been researched along with Diabetes Mellitus, Type 2 in 8 studies

Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.

Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Research Excerpts

ExcerptRelevanceReference
"Niclosamide piperazine salt may hold the promise to become an alternative to NEN as a drug lead for the treatment of obesity and T2D."7.91Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice. ( Alasadi, A; Guo, J; Huang, Q; Jin, S; Tao, H, 2019)
"Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide."4.98Niclosamide: Beyond an antihelminthic drug. ( Chen, W; Mook, RA; Premont, RT; Wang, J, 2018)
"Niclosamide piperazine salt may hold the promise to become an alternative to NEN as a drug lead for the treatment of obesity and T2D."3.91Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice. ( Alasadi, A; Guo, J; Huang, Q; Jin, S; Tao, H, 2019)
"Metabolic disorders such as type 2 diabetes, fatty liver disease, hyperlipidemia, and obesity commonly co-occur but clinical treatment options do not effectively target all disorders."2.44Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice. ( Alexopoulos, SJ; Beretta, M; Byrne, FL; Cantley, J; Chen, SY; Garcia, CJ; Hoehn, KL; Larance, M; Olzomer, EM; Philp, A; Salamoun, JM; Santos, WL; Shah, DP; Smith, GC; Turner, N, 2024)
"Diabetic peripheral neuropathy (DPN), diabetic kidney disease (DKD), and diabetic retinopathy (DR) contribute to significant morbidity and mortality in diabetes patients."1.51Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes. ( Abcouwer, SF; Backus, C; Brosius, FC; Feldman, EL; Hayes, JM; Hinder, LM; Kayampilly, P; Lin, CM; O'Brien, PD; Pennathur, S; Rumora, AE; Sas, KM; Shanmugam, S; Zhang, H, 2019)
"Early diabetic kidney disease (DKD) is characterized by renal hypertrophy and albuminuria."1.48Niclosamide ethanolamine improves kidney injury in db/db mice. ( Ge, N; Han, P; Li, S; Shao, M; Song, G; Sun, H; Wang, W; Yi, T; Yu, X; Zhan, H; Zhang, C, 2018)
" Although the pharmacokinetic properties of NIC are appropriate for use as an anthelmintic agent, its low solubility, low bioavailability and low systemic exposure limit its usefulness in treating systemic diseases."1.46Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth. ( Bhattacharyya, J; Chen, W; Chilkoti, A; Li, X; Mook, RA; Premont, RT; Ren, XR; Spasojevic, I; Wang, J, 2017)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (87.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Chen, SY1
Beretta, M1
Olzomer, EM1
Alexopoulos, SJ1
Shah, DP1
Byrne, FL1
Salamoun, JM1
Garcia, CJ1
Smith, GC3
Larance, M1
Philp, A1
Turner, N2
Santos, WL1
Cantley, J1
Hoehn, KL1
Chen, W2
Mook, RA2
Premont, RT2
Wang, J2
Guo, J1
Tao, H1
Alasadi, A1
Huang, Q1
Jin, S1
Bhattacharyya, J1
Ren, XR1
Spasojevic, I1
Li, X1
Chilkoti, A1
Han, P1
Zhan, H1
Shao, M1
Wang, W1
Song, G1
Yu, X1
Zhang, C1
Ge, N1
Yi, T1
Li, S1
Sun, H1
Hinder, LM1
Sas, KM1
O'Brien, PD1
Backus, C1
Kayampilly, P1
Hayes, JM1
Lin, CM1
Zhang, H1
Shanmugam, S1
Rumora, AE1
Abcouwer, SF1
Brosius, FC1
Pennathur, S1
Feldman, EL1
Chowdhury, MK2
Wu, LE2
Coleman, JL1
Smith, NJ1
Morris, MJ2
Shepherd, PR2
Bentley, NL1
Das, A1
Richani, D1
Bustamante, S1
Gilchrist, RB1

Reviews

1 review available for niclosamide and Diabetes Mellitus, Type 2

ArticleYear
Niclosamide: Beyond an antihelminthic drug.
    Cellular signalling, 2018, Volume: 41

    Topics: Animals; Anthelmintics; Arthritis, Rheumatoid; Diabetes Mellitus, Type 2; Disease Models, Animal; En

2018

Other Studies

7 other studies available for niclosamide and Diabetes Mellitus, Type 2

ArticleYear
Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice.
    Biochimica et biophysica acta. Molecular basis of disease, 2024, Volume: 1870, Issue:1

    Topics: Animals; Caloric Restriction; Diabetes Mellitus, Type 2; Ethanolamine; Ethanolamines; Female; Mice;

2024
Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice.
    Eating and weight disorders : EWD, 2019, Volume: 24, Issue:1

    Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Insulin Resistance; Mice

2019
Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.
    Nanoscale, 2017, Aug-31, Volume: 9, Issue:34

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Diabetes Mellitus, Type 2; Humans;

2017
Niclosamide ethanolamine improves kidney injury in db/db mice.
    Diabetes research and clinical practice, 2018, Volume: 144

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Ethanol

2018
Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes.
    Scientific reports, 2019, 01-29, Volume: 9, Issue:1

    Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopa

2019
Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling.
    The Biochemical journal, 2016, 05-01, Volume: 473, Issue:9

    Topics: Animals; beta Catenin; Bucladesine; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2;

2016
Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes.
    Scientific reports, 2017, 01-05, Volume: 7

    Topics: Animals; Body Composition; Body Weight; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Typ

2017