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niclosamide and Cell Transformation, Neoplastic

niclosamide has been researched along with Cell Transformation, Neoplastic in 3 studies

Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.

Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Research Excerpts

ExcerptRelevanceReference
"Niclosamide treatment attenuates Ras-induced oncogenic potential in vitro and in vivo."1.46Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3. ( Ahn, SY; Cha, YH; Choi, J; Kang, HE; Kim, HS; Kim, NH; Lee, K; Lee, Y; Yang, JH; Yook, JI; Yun, JS, 2017)
"Hepatocellular carcinoma was then developed in the transgenic zebrafish."1.42Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. ( Choi, JH; Chung, YY; Jung, IH; Lim, GL; Park, SW; Park, YN, 2015)
"In this study, we used CSC-like human breast cancer cells and their alternate subset non-CSCs to investigate how IL-6 regulates the conversion of non-CSCs to CSCs."1.39Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. ( Kang, JW; Kim, BK; Kim, SY; Kwon, YT; Lee, YJ; Song, X; Yoo, YD, 2013)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ahn, SY1
Yang, JH1
Kim, NH1
Lee, K1
Cha, YH1
Yun, JS1
Kang, HE1
Lee, Y1
Choi, J1
Kim, HS1
Yook, JI1
Jung, IH1
Choi, JH1
Chung, YY1
Lim, GL1
Park, YN1
Park, SW1
Kim, SY1
Kang, JW1
Song, X1
Kim, BK1
Yoo, YD1
Kwon, YT1
Lee, YJ1

Other Studies

3 other studies available for niclosamide and Cell Transformation, Neoplastic

ArticleYear
Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3.
    Oncotarget, 2017, May-09, Volume: 8, Issue:19

    Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activatio

2017
Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.
    Neoplasia (New York, N.Y.), 2015, Volume: 17, Issue:7

    Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclic S-Oxides

2015
Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells.
    Cellular signalling, 2013, Volume: 25, Issue:4

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytokines; Female; Gen

2013