niclosamide has been researched along with Cell Transformation, Neoplastic in 3 studies
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Niclosamide treatment attenuates Ras-induced oncogenic potential in vitro and in vivo." | 1.46 | Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3. ( Ahn, SY; Cha, YH; Choi, J; Kang, HE; Kim, HS; Kim, NH; Lee, K; Lee, Y; Yang, JH; Yook, JI; Yun, JS, 2017) |
| "Hepatocellular carcinoma was then developed in the transgenic zebrafish." | 1.42 | Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. ( Choi, JH; Chung, YY; Jung, IH; Lim, GL; Park, SW; Park, YN, 2015) |
| "In this study, we used CSC-like human breast cancer cells and their alternate subset non-CSCs to investigate how IL-6 regulates the conversion of non-CSCs to CSCs." | 1.39 | Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. ( Kang, JW; Kim, BK; Kim, SY; Kwon, YT; Lee, YJ; Song, X; Yoo, YD, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, SY | 1 |
| Yang, JH | 1 |
| Kim, NH | 1 |
| Lee, K | 1 |
| Cha, YH | 1 |
| Yun, JS | 1 |
| Kang, HE | 1 |
| Lee, Y | 1 |
| Choi, J | 1 |
| Kim, HS | 1 |
| Yook, JI | 1 |
| Jung, IH | 1 |
| Choi, JH | 1 |
| Chung, YY | 1 |
| Lim, GL | 1 |
| Park, YN | 1 |
| Park, SW | 1 |
| Kim, SY | 1 |
| Kang, JW | 1 |
| Song, X | 1 |
| Kim, BK | 1 |
| Yoo, YD | 1 |
| Kwon, YT | 1 |
| Lee, YJ | 1 |
3 other studies available for niclosamide and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activatio | 2017 |
Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.
Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclic S-Oxides | 2015 |
Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytokines; Female; Gen | 2013 |