niclosamide has been researched along with Astrocytoma, Grade IV in 6 studies
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Niclosamide is an anti-helminthic drug and recently it has been receiving attention due to its reported anticancer effects in cancer models, including GBM." | 5.72 | Combined treatment with niclosamide and camptothecin enhances anticancer effect in U87 MG human glioblastoma cells. ( Campano, P; Cheng, B; Fang, X; Gonzalez, D; Rodriguez, R; Tsin, A; Valdez, L, 2022) |
| "Glioblastoma is the most common and lethal malignant primary brain tumor for which the development of efficacious chemotherapeutic agents remains an urgent need." | 5.46 | Niclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell line. ( Cheng, B; Mito, S; Morales, LD; Tsin, A; Zhang, Y, 2017) |
| "Glioblastoma is a highly malignant, invariably fatal brain tumor for which effective pharmacotherapy remains an unmet medical need." | 5.39 | Anticancer effects of niclosamide in human glioblastoma. ( Brüstle, O; Fimmers, R; Glas, M; Gogolok, S; Höfer, H; Keller, M; Klaas, L; Koch, P; Leinhaas, A; Normann, S; Pietsch, T; Pincus, DW; Reinartz, R; Scheffler, B; Schelle, R; Simon, M; Steindler, DA; Trageser, D; Waha, A; Wieland, A; Yachnis, AT, 2013) |
| "Niclosamide is an anti-helminthic drug and recently it has been receiving attention due to its reported anticancer effects in cancer models, including GBM." | 1.72 | Combined treatment with niclosamide and camptothecin enhances anticancer effect in U87 MG human glioblastoma cells. ( Campano, P; Cheng, B; Fang, X; Gonzalez, D; Rodriguez, R; Tsin, A; Valdez, L, 2022) |
| "Glioblastoma is the most common and lethal malignant primary brain tumor for which the development of efficacious chemotherapeutic agents remains an urgent need." | 1.46 | Niclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell line. ( Cheng, B; Mito, S; Morales, LD; Tsin, A; Zhang, Y, 2017) |
| "Glioblastoma is a highly malignant, invariably fatal brain tumor for which effective pharmacotherapy remains an unmet medical need." | 1.39 | Anticancer effects of niclosamide in human glioblastoma. ( Brüstle, O; Fimmers, R; Glas, M; Gogolok, S; Höfer, H; Keller, M; Klaas, L; Koch, P; Leinhaas, A; Normann, S; Pietsch, T; Pincus, DW; Reinartz, R; Scheffler, B; Schelle, R; Simon, M; Steindler, DA; Trageser, D; Waha, A; Wieland, A; Yachnis, AT, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Fernandes, GFDS | 1 |
| Fernandes, BC | 1 |
| Valente, V | 1 |
| Dos Santos, JL | 1 |
| Valdez, L | 1 |
| Cheng, B | 2 |
| Gonzalez, D | 1 |
| Rodriguez, R | 1 |
| Campano, P | 1 |
| Tsin, A | 2 |
| Fang, X | 1 |
| Oh, HC | 1 |
| Shim, JK | 1 |
| Park, J | 1 |
| Lee, JH | 1 |
| Choi, RJ | 1 |
| Kim, NH | 1 |
| Kim, HS | 1 |
| Moon, JH | 1 |
| Kim, EH | 1 |
| Chang, JH | 1 |
| Yook, JI | 1 |
| Kang, SG | 1 |
| Morales, LD | 1 |
| Zhang, Y | 1 |
| Mito, S | 1 |
| Gersey, Z | 1 |
| Osiason, AD | 1 |
| Bloom, L | 1 |
| Shah, S | 1 |
| Thompson, JW | 1 |
| Bregy, A | 1 |
| Agarwal, N | 1 |
| Komotar, RJ | 1 |
| Wieland, A | 1 |
| Trageser, D | 1 |
| Gogolok, S | 1 |
| Reinartz, R | 1 |
| Höfer, H | 1 |
| Keller, M | 1 |
| Leinhaas, A | 1 |
| Schelle, R | 1 |
| Normann, S | 1 |
| Klaas, L | 1 |
| Waha, A | 1 |
| Koch, P | 1 |
| Fimmers, R | 1 |
| Pietsch, T | 1 |
| Yachnis, AT | 1 |
| Pincus, DW | 1 |
| Steindler, DA | 1 |
| Brüstle, O | 1 |
| Simon, M | 1 |
| Glas, M | 1 |
| Scheffler, B | 1 |
2 reviews available for niclosamide and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Recent advances in the discovery of small molecules targeting glioblastoma.
Topics: Animals; Central Nervous System Neoplasms; Drug Discovery; Glioblastoma; Humans; Neoplastic Stem Cel | 2019 |
Therapeutic Targeting of the Notch Pathway in Glioblastoma Multiforme.
Topics: ADAM Proteins; Amyloid Precursor Protein Secretases; Antineoplastic Agents; Arsenic Trioxide; Brain | 2019 |
4 other studies available for niclosamide and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Combined treatment with niclosamide and camptothecin enhances anticancer effect in U87 MG human glioblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Camptothecin; Cell Line, Tumor; DNA Topoisomerase | 2022 |
Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Sur | 2020 |
Niclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell line.
Topics: Anthelmintics; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cadaverine; Cell Line, Tumor; Cell | 2017 |
Anticancer effects of niclosamide in human glioblastoma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioblasto | 2013 |