niclofolan and Fascioliasis

Eight desert sheep were each infected orally with 500 metacercariae of Fasciola gigantica and, after 4 weeks, four of the animals were given niclofolan orally at the recommended therapeutic dose rate of 7 mg/kg, the other four remaining as controls. One week later, the animals were slaughtered and the fasciocidal effect of the drug was evaluated on the basis of worm burden, haemogram, some plasma constituents, and gross and histopathological lesions of the liver, as indicators of efficacy. The treatment was found to be ineffective, the degree of infection remaining the same as in the untreated control group. The experiment was repeated using eight infected sheep: four were given the drug orally at a dose rate of 10.5 mg/kg, i.e., 1.5 times the recommended dose; and the same parameters were measured as described above. The drug failed to cure the infected sheep, and caused depression, anorexia and weakness. In a third experiment six sheep were infected as before and three were treated with niclofolan by deep i.m. injection at the recommended therapeutic dose of 2 mg/kg. A week later the animals were killed and examined as before. The drug was effective in treating the infection and produced no untoward effects except for transient signs of pain at the site of injection. It seems possible that the oral dose, unlike the i.m. dose, of niclofolan is not absorbed and/or metabolized sufficiently to prevent elimination of the infection.

Topics: Animals; Fascioliasis; Niclofolan; Nitrophenols; Sheep; Sheep Diseases

A new fasciolicide, triclabendazole, tested at single oral dose rates of 5 and 10 mg/kg body-weight, proved to be highly effective (greater than 99%) against chronic field infections of Fasciola hepatica and F. gigantica in sheep. The performance of the new drug compared favourably with niclofolan at the recommended dose. Neither product was effective against Dicrocoelium dendriticum and Paramphistomum spp.

Topics: Animals; Anthelmintics; Benzimidazoles; Chronic Disease; Fasciola hepatica; Fascioliasis; Female; Niclofolan; Nitrophenols; Sheep; Sheep Diseases; Triclabendazole

Topics: Animals; Cattle; Cattle Diseases; Democratic Republic of the Congo; Disease Vectors; Fasciola hepatica; Fascioliasis; Feces; Lymnaea; Niclofolan; Parasite Egg Count

Triclabendazole (Fasinex), a new fasciolicide of the benzimidazole group, was tested in sheep and goats. A controlled test with 24 artificially-infected sheep revealed a 100% efficacy of triclabendazole at a dose of 10 mg kg-1 body weight against Fasciola hepatica aged 4 and 13 weeks, respectively. In naturally-acquired severe subacute to chronic fascioliasis in 66 sheep and 10 goats, the drug was highly effective in three trials when applied at 10 mg kg-1 in sheep and at 5 mg kg-1 in goats. Triclabendazole was well tolerated, whereas side effects occurred in one trial with niclofolan (Bilevon-M) (3 mg kg-1) which was used for comparison.

Topics: Animals; Anthelmintics; Benzimidazoles; Fasciola hepatica; Fascioliasis; Feces; Goats; Niclofolan; Parasite Egg Count; Sheep; Sheep Diseases; Triclabendazole

Topics: Adult; Cholestasis, Intrahepatic; Fascioliasis; Female; Humans; Niclofolan; Nitrophenols

We report a case of human Fasciola hepatica infection. For the first time evidence is presented of successful treatment of fascioliasis by oral administration of niclofolan, a biphenyl anthelmintic compound that is available for clinical testing in West Germany. Niclofolan therapy achieved elimination of eggs from the feces and normalization of eosinophil counts, liver enzymes and Fasciola titers, suggesting eradication of biliary flukes in our patient.

Topics: Adult; Fascioliasis; Female; Humans; Niclofolan; Nitrophenols; Parasite Egg Count

Dovenix and Bilevon-injection (manufactured by SPECIA, France and BAYER, West Germany, respectively) were tested for their anthelmintic efficacy against Fasciola hepatica in cattle. The drugs proved highly effective against both adult and immature flukes. The faeces of the treated animals were negative for F. hepatica eggs when examined 91 days after the treatment. In experiments with rats Dovenix and Bilevon-injection were tolerated up to eight times and ten times higher doses than the normal therapeutic dose, respectively.

Topics: Animals; Anthelmintics; Cattle; Cattle Diseases; Fasciola hepatica; Fascioliasis; Female; Niclofolan; Nitrophenols; Nitroxinil; Rats

Topics: Animals; Anthelmintics; Cattle; Cattle Diseases; Drug Evaluation; Drug Evaluation, Preclinical; Fascioliasis; Female; Niclofolan; Time Factors

Topics: Animals; Anthelmintics; Cattle; Cattle Diseases; Diamfenetide; Dose-Response Relationship, Drug; Drug Evaluation; Fascioliasis; Isomerism; Male; Niclofolan; Sulfamerazine

Topics: Animals; Cattle; Cattle Diseases; Fascioliasis; Injections, Intravenous; Niclofolan; Nitrophenols

Topics: Animals; Drug Evaluation, Preclinical; Fasciola hepatica; Fascioliasis; Niclofolan; Oxyclozanide; Rabbits; Rafoxanide; Rats; Trematode Infections

Topics: Animals; Anthelmintics; Cattle; Cattle Diseases; Drug Therapy; Fascioliasis; Hexachlorophene; Niclofolan; Nitrophenols