nickel has been researched along with Pulmonary Fibrosis in 23 studies
Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
nickel ion : A nickel atom having a net electric charge.
nickel atom : Chemical element (nickel group element atom) with atomic number 28.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nickel oxide nanoparticles (NiO NPs) causes pulmonary fibrosis via activating transforming growth factor-β1 (TGF-β1) in rats, but its upstream regulatory mechanisms are unknown." | 8.02 | LncRNA MEG3 mediates nickel oxide nanoparticles-induced pulmonary fibrosis via suppressing TGF-β1 expression and epithelial-mesenchymal transition process. ( Chang, X; Gao, Q; Li, C; Li, S; Liu, H; Sun, Y; Wang, X; Yang, M; Zhan, H, 2021) |
| "Animal studies have shown that nickel compounds may induce pulmonary fibrosis, but so far only limited documentation in humans has been available." | 7.72 | Radiographic evidence of pulmonary fibrosis and possible etiologic factors at a nickel refinery in Norway. ( Berge, SR; Skyberg, K, 2003) |
| "To identify pulmonary fibrosis, Masson trichrome staining, hydroxyproline content, and collagen protein expression were performed." | 5.46 | Nickel oxide nanoparticles induced pulmonary fibrosis via TGF- β1 activation in rats. ( Chang, XH; Han, AJ; Li, J; Li, S; Liu, FF; Liu, SK; Su, L; Sun, YB; Sun, YF; Sun, YY; Zhou, HH; Zhu, A; Zou, LY, 2017) |
| "Nickel oxide nanoparticles (NiO NPs) causes pulmonary fibrosis via activating transforming growth factor-β1 (TGF-β1) in rats, but its upstream regulatory mechanisms are unknown." | 4.02 | LncRNA MEG3 mediates nickel oxide nanoparticles-induced pulmonary fibrosis via suppressing TGF-β1 expression and epithelial-mesenchymal transition process. ( Chang, X; Gao, Q; Li, C; Li, S; Liu, H; Sun, Y; Wang, X; Yang, M; Zhan, H, 2021) |
| "Nickel oxide nanoparticles (Nano NiO) could induce pulmonary fibrosis, however, the mechanisms are still unknown." | 3.91 | TGF-β1 mediated MAPK signaling pathway promotes collagen formation induced by Nano NiO in A549 cells. ( Chang, X; Li, C; Li, S; Sun, Y; Tian, M; Zhang, Q, 2019) |
| "Animal studies have shown that nickel compounds may induce pulmonary fibrosis, but so far only limited documentation in humans has been available." | 3.72 | Radiographic evidence of pulmonary fibrosis and possible etiologic factors at a nickel refinery in Norway. ( Berge, SR; Skyberg, K, 2003) |
| "To identify pulmonary fibrosis, Masson trichrome staining, hydroxyproline content, and collagen protein expression were performed." | 1.46 | Nickel oxide nanoparticles induced pulmonary fibrosis via TGF- β1 activation in rats. ( Chang, XH; Han, AJ; Li, J; Li, S; Liu, FF; Liu, SK; Su, L; Sun, YB; Sun, YF; Sun, YY; Zhou, HH; Zhu, A; Zou, LY, 2017) |
| "One cause of debilitating pulmonary fibrosis is inhalation of insoluble metals." | 1.31 | Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells. ( Andrew, A; Barchowsky, A, 2000) |
| "Experiments on acute and chronic inhalation of copper and nickel sulfide ore dust proved that the dust of rich ore, if compared with that of copper-bearing and impregnated ore, induces more marked toxic effects." | 1.30 | [Fibrogenic and general toxic effects of copper and nickel sulfide ore dust (data for a hygienic evaluation)]. ( Borisenkova, RV; Gvozdeva, LL; Ivanova, LG; Lutsenko, LA; Skriabin, SIu, 1997) |
| "This report presents the results of noncancer dose-response modeling for inhalation and oral exposures to nickel compounds using the NOAEL/LOAEL and benchmark dose (BMD) approaches." | 1.30 | Non-cancer risk assessment for nickel compounds: issues associated with dose-response modeling of inhalation and oral exposures. ( Allen, BC; Haber, LT; Kimmel, CA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (39.13) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Mo, Y | 1 |
| Zhang, Y | 1 |
| Wan, R | 1 |
| Jiang, M | 1 |
| Xu, Y | 1 |
| Zhang, Q | 2 |
| Zhan, H | 1 |
| Chang, X | 2 |
| Wang, X | 1 |
| Yang, M | 1 |
| Gao, Q | 1 |
| Liu, H | 1 |
| Li, C | 3 |
| Li, S | 3 |
| Sun, Y | 2 |
| Wu, CH | 2 |
| Hsiao, YM | 1 |
| Yeh, KT | 1 |
| Tsou, TC | 1 |
| Chen, CY | 1 |
| Wu, MF | 1 |
| Ko, JL | 2 |
| Yang, L | 1 |
| Lin, Z | 1 |
| Wang, Y | 1 |
| Xu, W | 1 |
| Li, Q | 1 |
| Yao, W | 1 |
| Song, Z | 1 |
| Liu, G | 1 |
| Tian, M | 1 |
| Glista-Baker, EE | 1 |
| Taylor, AJ | 1 |
| Sayers, BC | 1 |
| Thompson, EA | 1 |
| Bonner, JC | 1 |
| Chang, XH | 1 |
| Zhu, A | 1 |
| Liu, FF | 1 |
| Zou, LY | 1 |
| Su, L | 1 |
| Liu, SK | 1 |
| Zhou, HH | 1 |
| Sun, YY | 1 |
| Han, AJ | 1 |
| Sun, YF | 1 |
| Li, J | 1 |
| Sun, YB | 1 |
| Tang, SC | 1 |
| Wang, PH | 1 |
| Lee, H | 1 |
| Berge, SR | 1 |
| Skyberg, K | 1 |
| Woźniak, H | 1 |
| Muir, DC | 1 |
| Julian, J | 1 |
| Jadon, N | 1 |
| Roberts, R | 1 |
| Roos, J | 1 |
| Chan, J | 1 |
| Maehle, W | 1 |
| Morgan, WK | 1 |
| Benson, JM | 1 |
| Chang, IY | 1 |
| Cheng, YS | 1 |
| Hahn, FF | 1 |
| Kennedy, CH | 1 |
| Barr, EB | 1 |
| Maples, KR | 1 |
| Snipes, MB | 1 |
| Lutsenko, LA | 1 |
| Borisenkova, RV | 1 |
| Gvozdeva, LL | 1 |
| Skriabin, SIu | 1 |
| Ivanova, LG | 1 |
| Haber, LT | 1 |
| Allen, BC | 1 |
| Kimmel, CA | 1 |
| Andrew, A | 1 |
| Barchowsky, A | 1 |
| Stettler, LE | 2 |
| Groth, DH | 1 |
| MacKay, GR | 1 |
| Proctor, JE | 1 |
| Platek, SF | 1 |
| Carolan, RJ | 1 |
| Smith, RJ | 1 |
| Donaldson, HM | 1 |
| Schneider, WD | 1 |
| Konetzke, GW | 1 |
| Siegesmund, KA | 1 |
| Funahashi, A | 1 |
| Pintar, K | 1 |
| Cralley, LJ | 1 |
| Lainhart, WS | 1 |
| Jones, JG | 1 |
| Warner, CG | 1 |
| Kosova, LV | 1 |
| Kurennaia, SS | 1 |
| Latushkina, VB | 1 |
| Kochetkova, TA | 1 |
| Kireev, VI | 1 |
| Tolgskaia, MS | 1 |
23 other studies available for nickel and Pulmonary Fibrosis
| Article | Year |
|---|---|
miR-21 mediates nickel nanoparticle-induced pulmonary injury and fibrosis.
Topics: Animals; Cytokines; Lung; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Na | 2020 |
LncRNA MEG3 mediates nickel oxide nanoparticles-induced pulmonary fibrosis via suppressing TGF-β1 expression and epithelial-mesenchymal transition process.
Topics: Animals; Epithelial-Mesenchymal Transition; Male; Nanoparticles; Nickel; Pulmonary Fibrosis; Rats; R | 2021 |
Upregulation of microRNA-4417 and Its Target Genes Contribute to Nickel Chloride-promoted Lung Epithelial Cell Fibrogenesis and Tumorigenesis.
Topics: Cell Line, Transformed; Cell Transformation, Neoplastic; Epithelial Cells; Humans; Lung; Lung Neopla | 2017 |
Nickle(II) ions exacerbate bleomycin-induced pulmonary inflammation and fibrosis by activating the ROS/Akt signaling pathway.
Topics: A549 Cells; Animals; Bleomycin; Cell Survival; Disease Models, Animal; Humans; Mice; Mice, Inbred C5 | 2018 |
TGF-β1 mediated MAPK signaling pathway promotes collagen formation induced by Nano NiO in A549 cells.
Topics: A549 Cells; Collagen Type I; Humans; Hydroxyproline; MAP Kinase Signaling System; Mitogen-Activated | 2019 |
Nickel nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet).
Topics: Airway Remodeling; Animals; Antibodies, Blocking; Antibodies, Monoclonal; Bronchoalveolar Lavage Flu | 2014 |
Nickel oxide nanoparticles induced pulmonary fibrosis via TGF- β1 activation in rats.
Topics: Animals; Gene Expression Regulation; Male; Metal Nanoparticles; Nickel; Pulmonary Fibrosis; Rats; Ra | 2017 |
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.
Topics: Acetylcysteine; Antigens, Differentiation; Azacitidine; Bronchi; Cadherins; Cell Line, Transformed; | 2012 |
Radiographic evidence of pulmonary fibrosis and possible etiologic factors at a nickel refinery in Norway.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Humans; Male; Middle Aged; Nickel; Norway; Occupational | 2003 |
[Polish asbestos and its fibrogenic effect. I. Fibrous minerals in nickel ore deposits].
Topics: Animals; Asbestos; Asbestosis; Chromium; Copper; Crystallization; Iron; Mining; Nickel; Particle Siz | 1984 |
Prevalence of small opacities in chest radiographs of nickel sinter plant workers.
Topics: Adult; Aged; Carcinogens; Dust; Humans; Lung; Male; Metallurgy; Middle Aged; Nickel; Occupational Di | 1993 |
Particle clearance and histopathology in lungs of F344/N rats and B6C3F1 mice inhaling nickel oxide or nickel sulfate.
Topics: Administration, Inhalation; Animals; Hyperplasia; Lung; Lung Diseases, Interstitial; Macrophages, Al | 1995 |
[Fibrogenic and general toxic effects of copper and nickel sulfide ore dust (data for a hygienic evaluation)].
Topics: Animals; Copper; Dust; Male; Maximum Allowable Concentration; Mining; Nickel; Pneumoconiosis; Pulmon | 1997 |
Non-cancer risk assessment for nickel compounds: issues associated with dose-response modeling of inhalation and oral exposures.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Humans; Inhalation Exposure; Lung; | 1998 |
Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells.
Topics: Bronchi; Epithelial Cells; Fibrinolysis; Humans; Nickel; Plasminogen Activator Inhibitor 1; Pulmonar | 2000 |
Identification of stainless steel welding fume particulates in human lung and environmental samples using electron probe microanalysis.
Topics: Air Pollutants, Occupational; Chromium; Electron Probe Microanalysis; Environmental Exposure; Filtra | 1977 |
Fibrogenicity and carcinogenic potential of smelter slags used as abrasive blasting substitutes.
Topics: Air Pollutants, Occupational; Animals; Copper; Dust; Environmental Exposure; Granuloma; Lung Neoplas | 1988 |
[Comment on the contribution by B. Wiemann and L. Bergmann. "Development of bronchial cancer at the site of siderofibrosis"].
Topics: Air Pollutants, Occupational; Carcinoma, Bronchogenic; Chromium; Humans; Lung Neoplasms; Nickel; Occ | 1989 |
Identification of metals in lung from a patient with interstitial pneumonia.
Topics: Chromium; Cobalt; Cytological Techniques; Humans; Iron; Lung; Macrophages; Male; Metals; Methods; Mi | 1974 |
Are trace metals associated with asbestos fibers responsible for the biologic effects attributed to asbestos?
Topics: Aluminum; Animals; Asbestos; Asbestosis; Chromium; Dust; Environmental Exposure; Fibrosarcoma; Human | 1973 |
Chronic exposure to iron oxide, chromium oxide, and nickel oxide fumes of metal dressers in a steelworks.
Topics: Adolescent; Adult; Alloys; Chromium; Environmental Exposure; Humans; Iron; Male; Metallurgy; Middle | 1972 |
[On the effect of oxyfers on the lung in experiments].
Topics: Animals; Bronchitis; Dust; Iron; Lung; Male; Nickel; Pneumoconiosis; Pulmonary Fibrosis; Rats; Zinc | 1967 |
[A study of the fibrogenic action of dust formed in the processing of pig iron and nickel alloys].
Topics: Animals; Dust; Iron; Metallurgy; Nickel; Pulmonary Fibrosis; Rats; Technology | 1969 |