nickel and Dermatitis, Allergic Contact studies

Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
nickel ion : A nickel atom having a net electric charge.
nickel atom : Chemical element (nickel group element atom) with atomic number 28.

Dermatitis, Allergic Contact: A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.

Research Excerpts

Excerpt	Relevance	Reference
"Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia cultivar), to peripheral lymphomonocytes from patients affected by allergic contact dermatitis (ACD) to nickel (Ni) could reduce the release of proinflammatory cytokines and nitric oxide (NO), while increasing the levels of interleukin (IL)-10, an anti-inflammatory cytokine."	9.41	Red Grape Polyphenol Oral Administration Improves Immune Response in Women Affected by Nickel-Mediated Allergic Contact Dermatitis. ( Foti, C; Jirillo, E; Magrone, M; Magrone, T; Massari, F; Romita, P; Russo, MA, 2021)
"1% tacrolimus ointment in treating nickel-induced allergic contact dermatitis (ACD) were evaluated."	9.12	A prospective randomized clinical trial of 0.1% tacrolimus ointment in a model of chronic allergic contact dermatitis. ( Anderson, B; Belsito, D; Ehrlich, A; Fowler, J; Rutledge, ES; Strober, BE; Warshaw, E; Willetts, J; Wilson, DC, 2006)
"1% in the treatment of nickel-induced allergic contact dermatitis, a T(H)1-mediated disease."	9.10	Tacrolimus ointment 0.1% in the treatment of nickel-induced allergic contact dermatitis. ( Belsito, DV; Gadzia, JE; Saripalli, YV, 2003)
"1% under occlusion for 48 h to suppress nickel-elicited allergic contact dermatitis in a randomized, petrolatum- and mometasone furoate 0."	9.10	Topical tacrolimus 0.1% ointment (protopic) reverses nickel contact dermatitis elicited by allergen challenge to a similar degree to mometasone furoate 0.1% with greater suppression of late erythema. ( Alomar, A; Gallardo, CM; Puig, L; Valenzuela, N, 2003)
"This study compares the cutaneous reactivity between the hand and the back for 7 female patients with active hand eczema, who were found to be nickel-sensitive on routine patch testing with the European standard series."	9.08	Cutaneous reactivity of the hands in nickel-sensitive patients with hand eczema. ( Banfield, CC; Basketter, DA; Powell, SM, 1998)
"Hypersensitivity to nickel is a very common cause of allergic contact dermatitis since this metal is largely present in industrial and consumer products as well as in some commonly consumed foods, air, soil, and water."	9.05	Mechanisms of Nickel-Induced Cell Damage in Allergic Contact Dermatitis and Nutritional Intervention Strategies. ( Cherpak, C; Filatova, D, 2020)
"Nickel is a very common metal contained in many everyday objects and is the leading cause of ACD (Allergic Contact Dermatitis)."	8.87	Systemic nickel hypersensitivity and diet: myth or reality? ( Pizzutelli, S, 2011)
"Nickel sulfate is the most frequently detected cause of allergic contact dermatitis in the world; the prevalence of nickel allergic contact dermatitis is between 8 and 11% in the general female population."	8.84	Genetics of nickel allergic contact dermatitis. ( Schram, SE; Warshaw, EM, 2007)
"Attempts have been made to elucidate the immunopathogenesis of contact allergy; yet, the exact mechanism by which nickel-induced allergic contact dermatitis (NACD) occurs is far from clear and is discussed herein."	8.79	The immunology of nickel-induced allergic contact dermatitis. ( Sosroseno, W, 1995)
"We aimed to assess if nickel sensitivity is more common in rosacea patients than the normal population."	7.91	Nickel Sensitivity in Rosacea Patients: A Prospective Case Control Study. ( Çifci, N, 2019)
"Nickel-induced allergic contact dermatitis (Ni-ACD) is a global health problem."	7.91	Analysis of nickel distribution by synchrotron radiation X-ray fluorescence in nickel-induced early- and late-phase allergic contact dermatitis in Hartley guinea pigs. ( Chen, DL; Chen, G; Gao, H; Jiang, SQ; Li, J; Li, Z; Liang, L; Sun, JL; Tang, R; Wei, RY; Wu, XY; Zhang, J; Zhao, ZT; Zhou, XJ, 2019)
"To investigate the expression profile of monocyte chemoattractant peptide-1 (MCP-1) by keratinocytes after nickel exposure and to identify its role for leucocyte migration during nickel-induced occupational allergic contact dermatitis (OACD), 26 workers diagnosed with nickel-induced OACD were enrolled."	7.88	MCP-1 produced by keratinocytes is associated with leucocyte recruitment during elicitation of nickel-induced occupational allergic contact dermatitis. ( Chen, L; Liu, X; Lu, D; Mai, W, 2018)
"The ingestion of nickel (Ni)-rich foods may result in allergic contact mucositis (ACM), a not yet well defined condition identifiable by oral mucosa patch test (omPT)."	7.80	Immunological characterization of the allergic contact mucositis related to the ingestion of nickel-rich foods. ( Amodeo, R; Borghini, R; Cardelli, P; Casale, R; Cristaudo, A; De Pità, O; Di Tola, M; Manna, F; Marino, M; Picarelli, A; Portaro, L; Rossi, A; Tabacco, F, 2014)
"Nickel (Ni) exposure through the intestinal mucosa may cause a hypersensitivity reaction recently defined as allergic contact mucositis (ACM)."	7.80	Peripheral blood lymphocyte typing as a useful tool to objectify the oral mucosa patch test in the diagnosis of allergic contact mucositis to nickel. ( Amodeo, R; Bove, M; Cardelli, P; Casale, R; Di Tola, M; Marino, M; Picarelli, A; Rossi, A; Tabacco, F, 2014)
"Nickel sensitization is a growing problem and the most common cause of allergic contact dermatitis."	7.76	Nickel-induced allergy and contact dermatitis: does it induce autoimmunity and cutaneous sclerosis? An experimental study in Brown Norway rats. ( Adam, M; Al-Arfaj, AS; Al-Hammad, A; Al-Mogairen, SM; Al-Mohimed, B; El Rab, MO; Hamdani, M; Husain, S; Meo, SA, 2010)
"Metal-induced allergic reactions are not rare in every day practice but nickel, cobalt and chromium are the most common offenders."	7.76	Nickel allergy, Kounis syndrome and intracardiac metal devices. ( Almpanis, GC; Kounis, GN; Kounis, NG; Koutsojannis, C; Mazarakis, A; Tsigkas, GG, 2010)
"The precise roles of T helper (Th)1-type and Th2-type cytokine responses in nickel (Ni)-induced allergic contact dermatitis have not yet been clearly defined."	7.76	Th2 immune response plays a critical role in the development of nickel-induced allergic contact dermatitis. ( Amoh, Y; Habu, S; Kanoh, M; Katsuoka, K; Komotori, J; Matsumura, Y; Niiyama, S; Tamauchi, H; Terashima, M, 2010)
"An association between nickel contact allergy and hand eczema has previously been demonstrated."	7.75	The association between hand eczema and nickel allergy has weakened among young women in the general population following the Danish nickel regulation: results from two cross-sectional studies. ( Johansen, JD; Linneberg, A; Menné, T; Nielsen, NH; Thyssen, JP, 2009)
" The aim of our study was to establish improved in vitro test protocol for the detection of antigen-specific responses of lymphocytes from patients with allergic contact dermatitis to nickel (Ni-ACD)."	7.74	Allergic contact dermatitis to nickel: modified in vitro test protocols for better detection of allergen-specific response. ( Bruynzeel, DP; Gibbs, S; Moed, H; Rustemeyer, T; Scheper, RJ; Spiewak, R; von Blomberg, BM, 2007)
"Nickel sulphate frequently causes allergic contact dermatitis; less known effects are nasal inflammation (rhinitis) and bronchial asthma."	7.74	Nickel sensitivity in asthma patients. ( Cakmak, SK; Gönül, M; Gül, U; Kiliç, A; Olcay, I, 2007)
"Many patients are currently suffering from nickel (Ni)-induced allergic contact dermatitis (ACD)."	7.74	Evaluating the nickel content in metal alloys and the threshold for nickel-induced allergic contact dermatitis. ( Kim, HO; Kim, MY; Kim, YY; Koh, CS; Lee, HK; Park, YM, 2008)
" The present study was undertaken to establish whether tinea pedis, atopic dermatitis or nickel allergy is a risk factor for development of vesicular eruptions."	7.72	Relation between vesicular eruptions on the hands and tinea pedis, atopic dermatitis and nickel allergy. ( Agner, T; Bryld, LE; Menné, T, 2003)
"The prevalence of nickel allergy (sensitization) and the associations with ear piercing, use of dental braces and hand eczema were assessed in a cohort of 1,501 8th grade schoolchildren (aged 12-16 years) in Odense, Denmark."	7.71	Nickel sensitization in adolescents and association with ear piercing, use of dental braces and hand eczema. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). ( Andersen, KE; Bindslev-Jensen, C; Lauritsen, JM; Mortz, CG, 2002)
"To investigate the mechanisms underlying the expression of allergic contact dermatitis, we compared the characteristics of nickel (Ni)-specific T cell responses in 10 patients with allergic contact dermatitis to Ni and in 10 healthy, nonallergic individuals."	7.70	Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells. ( Cavani, A; Corinti, S; Giani, M; Girolomoni, G; Guerra, E; Mei, D; Pirrotta, L; Puddu, P, 1998)
" The effect of vasoactive intestinal peptide (VIP) and of serotonin and its antagonists on the challenge phase of allergic contact dermatitis in humans were tested."	7.70	Inhibitory effect of vasoactive intestinal peptide on the challenge phase of allergic contact dermatitis in humans. ( Lundeberg, L; Mutt, V; Nordlind, K, 1999)
"The T cell response to nickel-modified endogenous peptides is involved in the immunopathogenesis of nickel-induced contact dermatitis."	7.69	TH2-type infiltrating T cells in nickel-induced contact dermatitis. ( Fleischer, B; Küntzlin, D; Probst, P, 1995)
"The prevalence of allergic contact dermatitis (ACD) caused by nickel is increasing."	7.69	Nickel release from metals, and a case of allergic contact dermatitis from stainless steel. ( Estlander, T; Jolanki, R; Kanerva, L; Sipiläinen-Malm, T; Tarvainen, K; Zitting, A, 1994)
" To investigate their potential immunomodulating role in established allergic contact dermatitis in man, the following neuromediators were tested: vasoactive intestinal polypeptide (VIP), serotonin, and the serotonin antagonists ketanserin, methiotepine and ICS-205-930."	7.69	Inhibitory effect of vasoactive intestinal polypeptide and ketanserin on established allergic contact dermatitis in man. ( Bondesson, L; Lidén, S; Mutt, V; Nordlind, K, 1996)
" In an extended model, we have studied the significance of previous allergic contact dermatitis for elicitation of delayed hypersensitivity to nickel in 25 nickel-allergic females."	7.69	The significance of previous allergic contact dermatitis for elicitation of delayed hypersensitivity to nickel. ( Bruze, M; Christensen, OB; Hindsén, M, 1997)
"Nickel is one of the most common causes of allergic contact dermatitis and produces more allergic reactions than all other metals combined."	7.68	Nickel hypersensitivity in the orthodontic patient. ( Bass, JK; Cisneros, GJ; Fine, H, 1993)
"Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia cultivar), to peripheral lymphomonocytes from patients affected by allergic contact dermatitis (ACD) to nickel (Ni) could reduce the release of proinflammatory cytokines and nitric oxide (NO), while increasing the levels of interleukin (IL)-10, an anti-inflammatory cytokine."	5.41	Red Grape Polyphenol Oral Administration Improves Immune Response in Women Affected by Nickel-Mediated Allergic Contact Dermatitis. ( Foti, C; Jirillo, E; Magrone, M; Magrone, T; Massari, F; Romita, P; Russo, MA, 2021)
"A subgroup of patients with atopic eczema develops acute eczematous reactions to type I allergy-inducing agents such as pollen that clinically resemble type IV allergies induced by haptens like metal ions."	5.36	Comparative in situ topoproteome analysis reveals differences in patch test-induced eczema: cytotoxicity-dominated nickel versus pleiotrope pollen reaction. ( Behrendt, H; Böckelmann, R; Bonnekoh, B; Cavani, A; Eyerich, K; Foerster, S; Gollnick, H; Hofmeister, H; Huss-Marp, J; Pommer, AJ; Ring, J; Traidl-Hoffmann, C, 2010)
"Allergic contact dermatitis is a delayed-type hypersensitivity reaction, secondary to hapten-specific T lymphocyte activation in sensitized individuals."	5.29	Establishment of nickel-specific T cell lines from patients with allergic contact dermatitis: comparison of different protocols. ( Bour, H; Demidem, A; Garrigue, JL; Nicolas, JF; Schmitt, D, 1994)
" 2009-013923-43) evaluating nickel oral hyposensitizing treatment (NiOHT) in patients with "systemic nickel allergy syndrome" (SNAS), characterized by Ni-allergic contact dermatitis and systemic reactions after eating Ni-rich food."	5.19	Nickel oral hyposensitization in patients with systemic nickel allergy syndrome. ( Ballone, E; Braga, M; De Pità, O; Di Gioacchino, M; Di Rienzo, V; Mangifesta, R; Minelli, M; Patella, V; Ricciardi, L; Schiavino, D; Voltolini, S, 2014)
"1% tacrolimus ointment in treating nickel-induced allergic contact dermatitis (ACD) were evaluated."	5.12	A prospective randomized clinical trial of 0.1% tacrolimus ointment in a model of chronic allergic contact dermatitis. ( Anderson, B; Belsito, D; Ehrlich, A; Fowler, J; Rutledge, ES; Strober, BE; Warshaw, E; Willetts, J; Wilson, DC, 2006)
" Tacrolimus and pimecrolimus are immunomodulators that provide clinicians with steroid-sparing options in the long-term topical treatment of allergic contact dermatitis."	5.12	A double-blind randomized placebo-controlled pilot study comparing topical immunomodulating agents and corticosteroids for treatment of experimentally induced nickel contact dermatitis. ( Bhardwaj, SS; Jaimes, JP; Liu, A; Warshaw, EM, 2007)
"The aim of this study was to evaluate the effect of a moisturizer containing urea on allergic contact dermatitis."	5.11	Effects of pretreatment with a urea-containing emollient on nickel allergic skin reactions. ( Edlund, F; Emtestam, L; Kuzmina, N; Lodén, M; Nyrén, M, 2005)
" We studied the safety of vascular adhesion protein-1 blockade by a single dose of the mouse monoclonal antibody vepalimomab in patients with nickel-induced allergic contact dermatitis lesions."	5.11	Safety of blocking vascular adhesion protein-1 in patients with contact dermatitis. ( Jaakkola, K; Jalkanen, S; Kalimo, K; Kortekangas-Savolainen, O; Mikkola, JH; Vainio, PJ; Veromaa, T, 2005)
"Concomitant patch test reactions to nickel and palladium have frequently been reported in patients undergoing investigation because of suspected allergic contact dermatitis."	5.11	Cross-reactivity between nickel and palladium demonstrated by systemic administration of nickel. ( Bruze, M; Hindsén, M; Spirén, A, 2005)
"1% in the treatment of nickel-induced allergic contact dermatitis, a T(H)1-mediated disease."	5.10	Tacrolimus ointment 0.1% in the treatment of nickel-induced allergic contact dermatitis. ( Belsito, DV; Gadzia, JE; Saripalli, YV, 2003)
"1% under occlusion for 48 h to suppress nickel-elicited allergic contact dermatitis in a randomized, petrolatum- and mometasone furoate 0."	5.10	Topical tacrolimus 0.1% ointment (protopic) reverses nickel contact dermatitis elicited by allergen challenge to a similar degree to mometasone furoate 0.1% with greater suppression of late erythema. ( Alomar, A; Gallardo, CM; Puig, L; Valenzuela, N, 2003)
"In this study we used the nickel contact allergy patch (CAP) test to investigate the effect of topical corticosteroids on allergic contact dermatitis (ACD)."	5.10	Efficacy of topical corticosteroids in nickel-induced contact allergy. ( Bogaerts, M; De Paepe, K; Hachem, JP; Kaufman, L; Rogiers, V; Roseeuw, D; Vanpée, E, 2002)
"The variation in nickel reactivity as shown in this article is of great importance and should be kept in mind when a patient has a positive history of allergic contact dermatitis but negative patch test results to nickel."	5.09	Individual variation in nickel patch test reactivity. ( Bruze, M; Christensen, OB; Hindsén, M, 1999)
"Exposure to nickel is a major cause of allergic contact dermatitis which is considered to be an inflammatory response induced by antigen-specific T cells."	5.09	Nickel-induced cytokine production from mononuclear cells in nickel-sensitive individuals and controls. Cytokine profiles in nickel-sensitive individuals with nickel allergy-related hand eczema before and after nickel challenge. ( Borg, L; Christensen, JM; Kristiansen, J; Menné, T; Nielsen, NH; Poulsen, LK, 2000)
" Patients with allergy to nickel were provoked with nickel sulfate epicutaneously, and the reactions were evaluated by a clinical scoring system (guidelines of the International Contact Dermatitis Research Group)."	5.09	Dual effects of CGRP-antagonist on allergic contact dermatitis in human skin. ( Wallengren, J, 2000)
"This study investigates lymphocyte subsets in both the gastrointestinal mucosa and blood, in patients with nickel allergic contact dermatitis, after 10 mg oral nickel challenge (double-blind, placebo-controlled)."	5.09	Lymphocyte subset changes in blood and gastrointestinal mucosa after oral nickel challenge in nickel-sensitized women. ( Andreassi, M; Angelucci, D; Boscolo, P; Cavallucci, E; Conti, P; Di Gioacchino, M; Di Sciascio, M; Di Stefano, F; Masci, S; Sabbioni, E; Verna, N, 2000)
"Chelating agents in protective barrier creams have often been used in the prevention of allergic contact dermatitis to nickel."	5.09	A cream containing the chelator DTPA (diethylenetriaminepenta-acetic acid) can prevent contact allergic reactions to metals. ( Brannath, W; Focke, M; Götz, M; Hemmer, W; Jarisch, R; Kriechbaumer, N; Wöhrl, S, 2001)
"In the assessment of the possibility of systemic allergic contact dermatitis from nickel, the dose as well as the intensity and time since previous nickel eczema have to be considered."	5.09	Flare-up reactions after oral challenge with nickel in relation to challenge dose and intensity and time of previous patch test reactions. ( Bruze, M; Christensen, OB; Hindsén, M, 2001)
"Nickel (Ni) allergic contact dermatitis (ACD) alters the skin barrier."	5.09	Combination therapy improves the recovery of the skin barrier function: an experimental model using a contact allergy patch test combined with TEWL measurements. ( De Paepe, K; Hachem, JP; Kaufman, L; Rogiers, V; Roseeuw, D; Vanpée, E, 2001)
"This study compares the cutaneous reactivity between the hand and the back for 7 female patients with active hand eczema, who were found to be nickel-sensitive on routine patch testing with the European standard series."	5.08	Cutaneous reactivity of the hands in nickel-sensitive patients with hand eczema. ( Banfield, CC; Basketter, DA; Powell, SM, 1998)
"Hypersensitivity to nickel is a very common cause of allergic contact dermatitis since this metal is largely present in industrial and consumer products as well as in some commonly consumed foods, air, soil, and water."	5.05	Mechanisms of Nickel-Induced Cell Damage in Allergic Contact Dermatitis and Nutritional Intervention Strategies. ( Cherpak, C; Filatova, D, 2020)
"Nickel is the most common cause of contact allergy in the general population and the most frequently detected allergen in patients patch tested for suspected allergic contact dermatitis (ACD)."	5.05	Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment and Prevention Programs. ( Agostinelli, D; Bianchi, L; Hansel, K; Stingeni, L; Tramontana, M, 2020)
"Nickel is a very common metal contained in many everyday objects and is the leading cause of ACD (Allergic Contact Dermatitis)."	4.87	Systemic nickel hypersensitivity and diet: myth or reality? ( Pizzutelli, S, 2011)
"Nickel hypersensitivity is a common problem, especially among young females, with a prevalence of 5 to 10%, increasing to 30%."	4.85	[Nickel allergy and orthodontics]. ( Jagtman, BA; Katsaros, C; Kuijpers-Jagtman, AM; Leenen, RL, 2009)
"Nickel sulfate is the most frequently detected cause of allergic contact dermatitis in the world; the prevalence of nickel allergic contact dermatitis is between 8 and 11% in the general female population."	4.84	Genetics of nickel allergic contact dermatitis. ( Schram, SE; Warshaw, EM, 2007)
"The transition metals nickel (Ni), chromium (Cr) and cobalt (Co) are common causes of allergic contact dermatitis (ACD)."	4.82	Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium. ( Angelini, G; Basketter, DA; Ingber, A; Kern, PS; Menné, T, 2003)
"Attempts have been made to elucidate the immunopathogenesis of contact allergy; yet, the exact mechanism by which nickel-induced allergic contact dermatitis (NACD) occurs is far from clear and is discussed herein."	4.79	The immunology of nickel-induced allergic contact dermatitis. ( Sosroseno, W, 1995)
"Aim of this study was to explore the nickel-specific cytokine profile to further elucidate the pathogenesis of nickel allergic contact dermatitis (ACD) and to identify potential new biomarkers for nickel ACD."	4.31	Nickel allergy is associated with a broad spectrum cytokine response. ( Bontkes, HJ; De Graaf, NPJ; Feilzer, AJ; Gibbs, S; Kleverlaan, CJ; Lopez Gonzalez, M; Roffel, S; Rustemeyer, T, 2023)
"Our findings help explain the high prevalence of contact dermatitis among hairdressers, alert clinicians to consider occult occupational nickel when assessing patients with allergic contact dermatitis, reinforces the importance of using barrier protection including gloves when handling hairdressing tools including at home, and augments impetus for more legislation regulating common allergens."	4.31	Nickel release from hairdressing tools in the United States. ( Chan, CX; Hamann, CR, 2023)
"Nickel-induced allergic contact dermatitis (ACD) is a common skin disease."	4.12	Autophagy involvement in T lymphocyte signalling induced by nickel with quantitative phosphoproteomic analysis. ( He, G; Huang, X; Li, P; Liu, X; Luo, X; Luo, Z; Shen, T; Tan, Y; Wang, G; Wang, Z; Yang, X; Yu, X; Zhang, B; Zhou, H, 2022)
"Nickel-induced allergic contact dermatitis (nACD) remains a major occupational skin disorder, significantly impacting the quality of life of suffering patients."	4.02	Integrative transcriptome analysis deciphers mechanisms of nickel contact dermatitis. ( Alenius, H; Berger, A; Fyhrquist, N; Jalonen, E; Lauerma, A; Werner, P; Wisgrill, L, 2021)
"We aimed to assess if nickel sensitivity is more common in rosacea patients than the normal population."	3.91	Nickel Sensitivity in Rosacea Patients: A Prospective Case Control Study. ( Çifci, N, 2019)
"Persistent antigenic stimulation due to repeated exposure to nickel may lead to chronic inflammation resulting in allergic contact dermatitis (ACD)."	3.91	Nickel challenge up regulates CD69 expression on T lymphocyte sub-sets from patients with nickel induced contact dermatitis. ( Dina, A; Felwa, A; Hasan, A; Mohammed, G; Mustafa, A; Sawsan, B; Zahid, S, 2019)
"Nickel-induced allergic contact dermatitis (Ni-ACD) is a global health problem."	3.91	Analysis of nickel distribution by synchrotron radiation X-ray fluorescence in nickel-induced early- and late-phase allergic contact dermatitis in Hartley guinea pigs. ( Chen, DL; Chen, G; Gao, H; Jiang, SQ; Li, J; Li, Z; Liang, L; Sun, JL; Tang, R; Wei, RY; Wu, XY; Zhang, J; Zhao, ZT; Zhou, XJ, 2019)
"To investigate the expression profile of monocyte chemoattractant peptide-1 (MCP-1) by keratinocytes after nickel exposure and to identify its role for leucocyte migration during nickel-induced occupational allergic contact dermatitis (OACD), 26 workers diagnosed with nickel-induced OACD were enrolled."	3.88	MCP-1 produced by keratinocytes is associated with leucocyte recruitment during elicitation of nickel-induced occupational allergic contact dermatitis. ( Chen, L; Liu, X; Lu, D; Mai, W, 2018)
"Nickel is a common allergen responsible for allergic contact dermatitis."	3.88	Epidemiology of pediatric nickel sensitivity: Retrospective review of North American Contact Dermatitis Group (NACDG) data 1994-2014. ( Aschenbeck, KA; Belsito, DV; DeKoven, JG; DeLeo, VA; Fowler, JF; Fransway, AF; Maibach, HI; Marks, JG; Mathias, T; Pratt, MD; Sasseville, D; Taylor, JS; Warshaw, EM; Zirwas, MJ; Zug, KA, 2018)
"Allergic contact dermatitis (ACD) is a major cause of occupational skin disease, and nickel is among the most prevalent contact allergens."	3.88	IL-27 Production and Regulation in Human Dendritic Cells Treated with the Chemical Sensitizer NiSO ( Antonios, D; Azouri, H; Bechara, R; Nabhan, M; Pallardy, M, 2018)
"Dear Editor, Nickel is a ubiquitous allergen and an important cause of allergic contact dermatitis (ACD)."	3.88	Allergic Contact Dermatitis to a Cell Phone. ( Chello, C; Gelormini, E; Magri, F; Parisella Francesca, R; Persechino, S; Pigliacelli, F; Tammaro, A, 2018)
"Nickel (Ni) is widely distributed in the environment and continuous exposure to this metal may lead to pathological manifestations, such as the human allergic contact dermatitis."	3.85	In Vitro Effects of Nickel on Healthy Non-Allergic Peripheral Blood Mononuclear Cells. The Role of Red Grape Polyphenols. ( Jirillo, E; Magrone, M; Magrone, T; Russo, MA; Salvatore, R; Spagnoletta, A, 2017)
"To evaluate the expression of TNF-α polymorphism in patients with allergic contact dermatitis and in healthy people, 41 patients with allergic contact dermatitis to nickel and 40 healthy controls were enrolled."	3.83	Role of TNF-alpha polymorphism in patients with nickel allergy: a marker of susceptibility to contact polysensitization. ( Colagiovanni, A; De Lorenzo, A; Di Renzo, L; Sarlo, F; Schiavino, D, 2016)
" Nickel sensitization and palmar hyperhidrosis tended to be more frequent among smokers than among non-smokers (nickel: 17/86 smokers, 6/67 non-smokers; hyperhidrosis: 21/84 smokers, 8/64 non-smokers)."	3.81	Smoking is associated with combined allergic and irritant hand eczema, contact allergies and hyperhidrosis. ( Herzinger, T; Molin, S; Ruzicka, T, 2015)
"We investigated fingers as a potential source of nickel transfer to the face in patients with allergic contact dermatitis to nickel and a history of facial dermatitis."	3.81	Nickel transfer by fingers. ( Isnardo, D; Panyella, D; Vidal, J; Vilaplana, J, 2015)
" We describe allergic contact dermatitis in 12 children with peri-umbilical nickel dermatitis (with and without generalized involvement) caused by dimethylglyoxime-positive belt buckles."	3.81	Belt Buckles-Increasing Awareness of Nickel Exposure in Children: A Case Report. ( Admani, S; Goldenberg, A; Jacob, SE; Pelletier, JL, 2015)
"To describe the prevalence of the different ILC subpopulations in skin from healthy controls and patients with psoriasis or allergy to nickel."	3.80	Increased number and frequency of group 3 innate lymphoid cells in nonlesional psoriatic skin. ( Agerbeck, C; Bonefeld, CM; Dyring-Andersen, B; Geisler, C; Gúdjonsdottir, SD; Lauritsen, JP; Skov, L, 2014)
"The ingestion of nickel (Ni)-rich foods may result in allergic contact mucositis (ACM), a not yet well defined condition identifiable by oral mucosa patch test (omPT)."	3.80	Immunological characterization of the allergic contact mucositis related to the ingestion of nickel-rich foods. ( Amodeo, R; Borghini, R; Cardelli, P; Casale, R; Cristaudo, A; De Pità, O; Di Tola, M; Manna, F; Marino, M; Picarelli, A; Portaro, L; Rossi, A; Tabacco, F, 2014)
"Nickel (Ni) exposure through the intestinal mucosa may cause a hypersensitivity reaction recently defined as allergic contact mucositis (ACM)."	3.80	Peripheral blood lymphocyte typing as a useful tool to objectify the oral mucosa patch test in the diagnosis of allergic contact mucositis to nickel. ( Amodeo, R; Bove, M; Cardelli, P; Casale, R; Di Tola, M; Marino, M; Picarelli, A; Rossi, A; Tabacco, F, 2014)
"We discuss allergic contact dermatitis to the iPad to highlight a potential source of nickel exposure in children."	3.80	iPad--increasing nickel exposure in children. ( Admani, S; Jacob, SE, 2014)
"Allergic contact dermatitis (ACD) is well recognized as an adverse event associated with implantable medical devices that contain allergenic materials like nickel; however, other cutaneous consequences of chronic exposure to allergens in implanted devices are not well understood."	3.80	Chronic allergic contact dermatitis promotes skin cancer. ( Cunningham, TJ; Demehri, S; Hurst, EA; Schaffer, A; Sheinbein, DM; Yokoyama, WM, 2014)
"Nickel is one of the most common allergens causing allergic contact dermatitis worldwide."	3.80	Risk assessment for nickel contact allergy. ( Boonchai, W; Chaiwanon, O; Kasemsarn, P, 2014)
"Metallic allergens such as nickel are among the most common causes of allergic contact dermatitis (ACD), but frequencies of contact dermatitis to these allergens may vary in different areas."	3.79	Allergic contact dermatitis to metal allergens in Iran. ( Babakoohi, S; Davari, P; Dowlati, Y; Firooz, A; Gorouhi, F; Kazerouni-Timsar, A; Khatami, A; Nassiri-Kashani, M; Sarraf-Yazdy, M, 2013)
"CD4(+) T cells producing IL-17, IL-22 and IFN-γ are important effector cells in the eczematous reactions of nickel-induced allergic contact dermatitis in humans."	3.79	CD4(+) T cells producing interleukin (IL)-17, IL-22 and interferon-γ are major effector T cells in nickel allergy. ( Bonefeld, CM; Bzorek, M; Dabelsteen, S; Dyring-Andersen, B; Geisler, C; Lauritsen, JP; Løvendorf, MB; Skov, L; Søndergaard, K, 2013)
" Patients with suspected allergic contact dermatitis who had been patch tested with nickel sulfate 5% in petrolatum were included in the analysis."	3.79	Nickel allergy following European Union regulation in Denmark, Germany, Italy and the U.K. ( Belloni Fortina, A; Garg, S; Gawkrodger, DJ; Johansen, JD; Menné, T; Schnuch, A; Statham, B; Thyssen, JP; Uter, W, 2013)
" The aim of the study was to determine the frequency of positive patch test reactions to metal contact allergens (potassium dichromate, cobalt chloride, nickel sulfate, white mercury precipitate) in patients diagnosed with allergic contact dermatitis, irritant contact dermatitis, and atopic dermatitis."	3.79	Patch test reactions to metal salts in patients with different types of dermatitis. ( Lipozenčić, J; Marinović Kulišić, S; Turčić, P, 2013)
"Nickel is widely used in coins; nickel may cause contact allergy and allergic contact dermatitis in those who handle them."	3.79	The cost of nickel allergy: a global investigation of coin composition and nickel and cobalt release. ( Hamann, C; Hamann, CR; Hamann, D; Lidén, C; Thyssen, JP, 2013)
"This study confirms that nickel levels on the skin in coin handling occupations and some others are sufficient to induce an allergic contact dermatitis in some nickel-allergic subjects."	3.78	Nickel skin levels in different occupations and an estimate of the threshold for reacting to a single open application of nickel in nickel-allergic subjects. ( Dobson, K; Gawkrodger, DJ; McLeod, CW, 2012)
"Despite the implementation of the Nickel Directive in Poland, nickel still remains an important causal factor for allergic contact dermatitis."	3.78	Contact allergy to metals in adolescents: nickel release from metal accessories 7 years after the implementation of the EU Nickel Directive in Poland. ( Chomiczewska, D; Kiec-Swierczynska, M; Krecisz, B; Palczynski, C, 2012)
"Nickel is a frequently detected cause of allergic contact dermatitis."	3.78	Influence of dietary factors, age and nickel contact dermatitis on nickel excretion. ( Behrendt, H; Darsow, U; Fedorov, M; Fromme, H; Habernegg, R; Ring, J; Schaller, KH; Schwegler, U; Twardella, D, 2012)
"Fiddler's neck refers to an irritant contact dermatitis on the submandibular neck of violin and viola players and an allergic contact dermatitis to nickel from the bracket attaching the violin to the chin rest on the violinist's supraclavicular neck."	3.78	Fiddler's neck: Chin rest-associated irritant contact dermatitis and allergic contact dermatitis in a violin player. ( Caero, JE; Cohen, PR, 2012)
" Monocyte-derived LCs (MoLCs), LCs, and skin sections of patients suffering from allergic contact dermatitis were challenged with nickel and then analyzed for PD-L1 expression by confocal laser scanning microscopy and flow cytometry."	3.78	Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy. ( Ebert, G; Heine, G; Hitzler, M; Luch, A; Majdic, O; Peiser, M; Worm, M, 2012)
"Recently, a crucial role of Th2 responses in nickel allergic contact dermatitis (ACD) was demonstrated."	3.78	Palladium-induced Th2 cytokine responses reflect skin test reactivity. ( Feilzer, AJ; Kleverlaan, CJ; Muris, J; Rustemeyer, T; Scheper, RJ; van Hoogstraten, IM; von Blomberg, BM, 2012)
"On contact with the skin, nickel may cause allergic contact dermatitis, which can be diagnosed by an epicutaneous patch test."	3.77	Oral mucosa patch test: a new tool to recognize and study the adverse effects of dietary nickel exposure. ( Carlesimo, M; Di Tola, M; Libanori, V; Magrelli, M; Picarelli, A; Rossi, A; Vallecoccia, A, 2011)
" This article briefly discusses a case of a professional musician with a unique allergic contact dermatitis to nickel sulfate and possibly palladium and cobalt chloride in his tuba."	3.77	Dermatologic manifestations of musicians: a case report and review of skin conditions in musicians. ( DeLeo, V; Vine, K, 2011)
" The purpose of our study was to characterize the expression of CCL27 and CCL17 in the inflammatory skin diseases: psoriasis, atopic dermatitis (AD) and acute allergic contact dermatitis (ACD) induced in nickel-sensitive individuals."	3.77	Kinetics and differential expression of the skin-related chemokines CCL27 and CCL17 in psoriasis, atopic dermatitis and allergic contact dermatitis. ( Bech, R; Iversen, L; Johansen, C; Kragballe, K; Riis, JL; Vestergaard, C, 2011)
"Nickel sensitization is a growing problem and the most common cause of allergic contact dermatitis."	3.76	Nickel-induced allergy and contact dermatitis: does it induce autoimmunity and cutaneous sclerosis? An experimental study in Brown Norway rats. ( Adam, M; Al-Arfaj, AS; Al-Hammad, A; Al-Mogairen, SM; Al-Mohimed, B; El Rab, MO; Hamdani, M; Husain, S; Meo, SA, 2010)
"Metal-induced allergic reactions are not rare in every day practice but nickel, cobalt and chromium are the most common offenders."	3.76	Nickel allergy, Kounis syndrome and intracardiac metal devices. ( Almpanis, GC; Kounis, GN; Kounis, NG; Koutsojannis, C; Mazarakis, A; Tsigkas, GG, 2010)
"The precise roles of T helper (Th)1-type and Th2-type cytokine responses in nickel (Ni)-induced allergic contact dermatitis have not yet been clearly defined."	3.76	Th2 immune response plays a critical role in the development of nickel-induced allergic contact dermatitis. ( Amoh, Y; Habu, S; Kanoh, M; Katsuoka, K; Komotori, J; Matsumura, Y; Niiyama, S; Tamauchi, H; Terashima, M, 2010)
"The concentration of released cobalt was high enough to elicit allergic contact dermatitis in cobalt-sensitized patients."	3.75	Cobalt-containing alloys and their ability to release cobalt and cause dermatitis. ( Hindsén, M; Julander, A; Lidén, C; Skare, L, 2009)
"An association between nickel contact allergy and hand eczema has previously been demonstrated."	3.75	The association between hand eczema and nickel allergy has weakened among young women in the general population following the Danish nickel regulation: results from two cross-sectional studies. ( Johansen, JD; Linneberg, A; Menné, T; Nielsen, NH; Thyssen, JP, 2009)
"Recently an alarming increase in the prevalence of allergic contact dermatitis (ACD) to nickel has been noted worldwide, with the majority of cases occurring in women and children."	3.75	Nickel-induced facial dermatitis: adolescents beware of the cell phone. ( Jacob, SE; Moennich, JN; Zirwas, M, 2009)
"Nickel, cobalt and chromium are some of the most common causes of type IV sensitizations and subsequent allergic contact dermatitis."	3.74	Patch test results with metals and meteorological conditions. ( Gefeller, O; Hegewald, J; Kranke, B; Pfahlberg, A; Schnuch, A; Uter, W, 2008)
" The aim of our study was to establish improved in vitro test protocol for the detection of antigen-specific responses of lymphocytes from patients with allergic contact dermatitis to nickel (Ni-ACD)."	3.74	Allergic contact dermatitis to nickel: modified in vitro test protocols for better detection of allergen-specific response. ( Bruynzeel, DP; Gibbs, S; Moed, H; Rustemeyer, T; Scheper, RJ; Spiewak, R; von Blomberg, BM, 2007)
"Nickel sulphate frequently causes allergic contact dermatitis; less known effects are nasal inflammation (rhinitis) and bronchial asthma."	3.74	Nickel sensitivity in asthma patients. ( Cakmak, SK; Gönül, M; Gül, U; Kiliç, A; Olcay, I, 2007)
"Nickel is a common cause of allergic contact dermatitis and is associated with metal buttons and snaps on blue jeans."	3.74	Blue-jean button nickel: prevalence and prevention of its release from buttons. ( Flanagan, KH; Glaser, DA; Suneja, T, 2007)
"Many patients are currently suffering from nickel (Ni)-induced allergic contact dermatitis (ACD)."	3.74	Evaluating the nickel content in metal alloys and the threshold for nickel-induced allergic contact dermatitis. ( Kim, HO; Kim, MY; Kim, YY; Koh, CS; Lee, HK; Park, YM, 2008)
"Nickel is the most common cause of allergic contact dermatitis (ACD)."	3.74	Nickel earlobe dermatitis and clinical non-relevance of the oral exposure. ( Alpini, D; Cesarani, A; Di Berardino, F, 2008)
" Most stents are made of stainless steel, and that, allergic reactions to nickel ions released from coronary stainless-steel stents may be one of the triggering mechanisms for in-stent restenosis."	3.73	Is there a link between nickel allergy and coronary stent restenosis? ( Aksu, H; Alper, AT; Hobikoglu, G; Narin, A; Norgaz, T; Ozer, O; Serdar, ZA, 2005)
" Diagnostic allergy testing revealed strong delayed hypersensitivity to nickel and a mild patch test reaction to the permanent lip liner."	3.73	[Contact dermatitis to permanent make up: manifestation of a pre-existing nickel allergy]. ( Jäger, C; Jappe, U, 2005)
"Nickel-elicited systemic contact dermatitis is a well-known entity, although it is far less common than allergic contact dermatitis."	3.73	Nickel-elicited systemic contact dermatitis from a peripheral intravenous catheter. ( Guilhou, JJ; Guillard, O; Guillot, B; Khalil, Z; Raison-Peyron, N, 2005)
"Nickel is knows as the most common cause of allergic contact dermatitis, as well as diffuse eczema, allergic rhinitis and bronchial asthma."	3.73	[Response of peripheral blood mononuclear leukocyte to nickel stimulation in patients with systemic and contact allergy to nickel]. ( Czarnobilska, E; Dyga, W; Kaszuba-Zwoinska, J; Obtułowicz, K; Stobiecki, M; Słodowska-Hajduk, Z; Thor, P; Wsołek, K, 2006)
" The present study was undertaken to establish whether tinea pedis, atopic dermatitis or nickel allergy is a risk factor for development of vesicular eruptions."	3.72	Relation between vesicular eruptions on the hands and tinea pedis, atopic dermatitis and nickel allergy. ( Agner, T; Bryld, LE; Menné, T, 2003)
"CD8+ T cells have been assigned a prominent role in allergic contact dermatitis, including nickel allergy; however, human nickel-reactive T cells of the CD8+ phenotype have largely escaped detailed investigation."	3.72	T cell receptor transfection shows non-HLA-restricted recognition of nickel by CD8+ human T cells to be mediated by alphabeta T cell receptors. ( Choleva, Y; Moulon, C; Thierse, HJ; Weltzien, HU; Wild, D, 2003)
"Keratinocytes play a key role in the pathogenesis of allergic contact dermatitis (ADC) induced by the sensitizing agent nickel."	3.72	Nickel-induced keratinocyte proliferation and up-modulation of the keratinocyte growth factor receptor expression. ( Aimati, L; Bellocci, M; Buttari, B; Cardinali, G; Kovacs, D; Marchese, C; Picardo, M; Torrisi, MR; Visco, V, 2003)
"To examine whether nickel-containing coins might be an elicitor of allergic contact dermatitis (ACD) in occupational settings with extensive exposure to coins (i."	3.72	Provocative use test of nickel coins in nickel-sensitized subjects and controls. ( Bashir, SJ; Chew, AL; Hostynek, JJ; Maibach, HI; Reagan, KE; Zhai, H, 2003)
"Nickel ions leached in sufficient quantities from nickel-containing alloys may induce nickel sensitization or elicit allergic contact dermatitis."	3.72	Release of nickel ions from stainless steel alloys used in dental braces and their patch test reactivity in nickel-sensitive individuals. ( Baadsgaard, O; Byrialsen, K; Jensen, CS; Lisby, S; Menné, T, 2003)
"We investigated the capacity of CD25(+) T regulatory cells (Treg) to modulate T cell responses to nickel, a common cause of allergic contact dermatitis."	3.72	Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals. ( Cavani, A; De Pità, O; Girolomoni, G; Nasorri, F; Ottaviani, C; Sebastiani, S, 2003)
"Nickel hypersensitivity represents a very common human disease state, mainly occurring in females, defined as allergic contact dermatitis."	3.72	In vitro effects of nickel-sulphate on immune functions of normal and nickel-allergic subjects: a regulatory role for zinc. ( Boscolo, P; Buttari, B; Camera, E; Dell'Anna, ML; Di Giampaolo, L; Di Gioacchino, M; Mastrofrancesco, A; Paganelli, R; Picardo, M; Reale, M; Sabbioni, E; Schiavone, C; Verna, N, 2003)
"Allergic contact dermatitis (ACD) reactions to nickel have pleomorphic presentations owing to the ubiquity of this allergen in the environment."	3.72	A diagnostic pearl: the school chair sign. ( Belsito, DV; Samimi, SS; Siegfried, E, 2004)
"The prevalence of nickel allergy (sensitization) and the associations with ear piercing, use of dental braces and hand eczema were assessed in a cohort of 1,501 8th grade schoolchildren (aged 12-16 years) in Odense, Denmark."	3.71	Nickel sensitization in adolescents and association with ear piercing, use of dental braces and hand eczema. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). ( Andersen, KE; Bindslev-Jensen, C; Lauritsen, JM; Mortz, CG, 2002)
" Twelve other patients with IgE-mediated allergy were treated by CFS on the lower arm for 1 h and were then pricked with histamine and allergen extracts (wheal volume was measured) and were tested using benzoic acid (nonimmunologic contact urticaria; closed test)."	3.71	Cutaneous field stimulation of sensory nerve fibers reduces itch without affecting contact dermatitis. ( Wallengren, J, 2002)
"Allergic contact dermatitis due to nickel salts is common."	3.71	In vitro permeation of nickel salts through human stratum corneum. ( Hostýnek, JJ; Maibach, HI; Mountford, HS; Tanojo, H, 2001)
"It has been found that infections, inappropriate supporter, allergy to nickel and gold, local delayed allergy are the chief factors to form keloides of the earlobes."	3.70	[Prevention of keloids of the earlobes]. ( Li, B; Liu, D; Tian, J; Zhou, C, 1999)
" There was no difference in the distribution of eczema in chromate-positive subjects, nor of cobalt co-sensitization, a crude indicator of sensitization via cement."	3.70	Contact sensitivity to chromate: comparison at a London contact dermatitis clinic over a 10-year period. ( McFadden, JP; Olsavszky, R; Rycroft, RJ; White, IR, 1998)
"To investigate the mechanisms underlying the expression of allergic contact dermatitis, we compared the characteristics of nickel (Ni)-specific T cell responses in 10 patients with allergic contact dermatitis to Ni and in 10 healthy, nonallergic individuals."	3.70	Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells. ( Cavani, A; Corinti, S; Giani, M; Girolomoni, G; Guerra, E; Mei, D; Pirrotta, L; Puddu, P, 1998)
"In 2 earlier studies, we found increased nickel re-test reactivity at earlier experimentally induced nickel eczema sites."	3.70	The significance of previous contact dermatitis for elicitation of contact allergy to nickel. ( Bruze, M; Hindsén, M, 1998)
"Among patients routinely undergoing patch testing for suspected allergic contact dermatitis (ACD), nickel is the most frequently sensitizing hapten, with a clear predominance in the female population."	3.70	Patch testing with nickel sulfate: comparison between 2 nickel sulfate preparations and 2 different test sites on the back. ( Manzini, BM; Seidenari, S; Simonetti, V, 1998)
"Contact hypersensitivity to nickel is the most common form of allergic contact dermatitis."	3.70	Nickel-induced activation of T cells in individuals with negative patch test to nickel sulphate. ( Baadsgaard, O; Hansen, LH; Lisby, S; Menné, T; Skov, L, 1999)
" The effect of vasoactive intestinal peptide (VIP) and of serotonin and its antagonists on the challenge phase of allergic contact dermatitis in humans were tested."	3.70	Inhibitory effect of vasoactive intestinal peptide on the challenge phase of allergic contact dermatitis in humans. ( Lundeberg, L; Mutt, V; Nordlind, K, 1999)
"We have examined evidence for familial disposition to nickel allergic contact dermatitis (Ni ACD)."	3.70	The genetics of allergic contact hypersensitivity to nickel. ( Burden, AD; Fleming, CJ; Forsyth, A, 1999)
"The aims of this study were to analyze the change in trend of allergic contact dermatitis (ACD) from nickel in a single tertiary referral centre."	3.70	The trend of nickel allergy from a Scottish tertiary referral centre. ( Dawn, G; Forsyth, A; Gupta, G, 2000)
"We calculated the IR of occupational allergic contact dermatitis (ACD) caused by chromium, nickel and cobalt by occupation, during a 7-year period (1991-1997) from the data of the Finnish Register of Occupational Diseases and from the statistics on the working population in different occupations."	3.70	Incidence rates of occupational allergic contact dermatitis caused by metals. ( Alanko, K; Estlander, T; Jolanki, R; Kanerva, L; Savela, A, 2000)
"We have studied, immunohistochemically, hypersensitivity reactions to corticosteroids and compared them with allergic contact dermatitis from nickel and appropriate controls."	3.69	Immunohistochemical appearance of corticosteroid contact hypersensitivity reactions. ( Andrew, SM; Beck, MH; Maseruka, H; Wilkinson, SM, 1994)
"The T cell response to nickel-modified endogenous peptides is involved in the immunopathogenesis of nickel-induced contact dermatitis."	3.69	TH2-type infiltrating T cells in nickel-induced contact dermatitis. ( Fleischer, B; Küntzlin, D; Probst, P, 1995)
"Nickel is the major cause of allergic contact dermatitis, and to increase our understanding of this immune reaction we studied changes in the expression of adhesion molecules on mononuclear cells during nickel stimulation in vivo and in vitro."	3.69	Adhesion molecules in the nickel allergic reaction. ( Kallioinen, M; Karvonen, J; Kauppinen, M; Silvennoinen-Kassinen, S; Vainio, O, 1995)
"Nickel release from nickel-plated metals often induces allergic contact dermatitis, but, for nickel-containing stainless steels, the effect is not well-known."	3.69	Nickel release from nickel-plated metals and stainless steels. ( Baroux, B; Foussereau, J; Haudrechy, P; Mantout, B, 1994)
"The prevalence of allergic contact dermatitis (ACD) caused by nickel is increasing."	3.69	Nickel release from metals, and a case of allergic contact dermatitis from stainless steel. ( Estlander, T; Jolanki, R; Kanerva, L; Sipiläinen-Malm, T; Tarvainen, K; Zitting, A, 1994)
" To investigate their potential immunomodulating role in established allergic contact dermatitis in man, the following neuromediators were tested: vasoactive intestinal polypeptide (VIP), serotonin, and the serotonin antagonists ketanserin, methiotepine and ICS-205-930."	3.69	Inhibitory effect of vasoactive intestinal polypeptide and ketanserin on established allergic contact dermatitis in man. ( Bondesson, L; Lidén, S; Mutt, V; Nordlind, K, 1996)
" In an extended model, we have studied the significance of previous allergic contact dermatitis for elicitation of delayed hypersensitivity to nickel in 25 nickel-allergic females."	3.69	The significance of previous allergic contact dermatitis for elicitation of delayed hypersensitivity to nickel. ( Bruze, M; Christensen, OB; Hindsén, M, 1997)
"In 1994, a study of nickel release and allergic contact dermatitis from nickel-plated metals and stainless steels was published in this journal."	3.69	Nickel release from stainless steels. ( Chabeau, G; Claudy, A; Faure, M; Frappaz, A; Haudrechy, P; Mantout, B; Rousseau, D, 1997)
"Nickel is one of the most common causes of allergic contact dermatitis and produces more allergic reactions than all other metals combined."	3.68	Nickel hypersensitivity in the orthodontic patient. ( Bass, JK; Cisneros, GJ; Fine, H, 1993)
"The transition metal nickel is a very common cause of allergic contact dermatitis (ACD)."	3.68	An arm immersion model of compromised skin (II). Influence on minimal eliciting patch test concentrations of nickel. ( Allenby, CF; Basketter, DA, 1993)
" The threshold for the ROAT (in microg nickel cm(-2) per application) was significantly lower than the threshold for the patch test, while the dose-response for the accumulated ROAT dose at 1 week, 2 weeks and 3 weeks was very similar to the patch test dose-response; indeed, there was no statistically significant difference."	2.73	Nickel allergy: relationship between patch test and repeated open application test thresholds. ( Fischer, LA; Johansen, JD; Menné, T, 2007)
" The aim of the current investigation was to study dose-response dependency of oral exposure to nickel."	2.71	Experimental systemic contact dermatitis from nickel: a dose-response study. ( Jensen, CS; Kristiansen, J; Lisby, S; Menné, T; Veien, NK, 2003)
"Nickel sulfate was given orally, gold sodium thiomalate intramuscularly, and placebo by both routes."	2.69	The flare-up reactions after systemic provocation in contact allergy to nickel and gold. ( Björkner, B; Bruze, M; Linder, C; Möller, H; Ohlsson, K, 1999)
" In addition, we wished to establish the dose-response relationship for nickel sulphate patch tests among nickel-sensitive patients."	2.67	Dose-response testing with nickel sulphate using the TRUE test in nickel-sensitive individuals. Multiple nickel sulphate patch-test reactions do not cause an 'angry back'. ( Andersen, KE; Hansen, J; Lidén, C; Vølund, A, 1993)
"Contact allergy and allergic contact dermatitis are frequent conditions in the general population."	2.61	Prevalence of contact allergy in the general population: A systematic review and meta-analysis. ( Alinaghi, F; Bennike, NH; Egeberg, A; Johansen, JD; Thyssen, JP, 2019)
"Allergic contact dermatitis is a frequent problem, it also constitutes a challenge to diagnose due to many potential contact allergens."	2.61	Highlights in allergic contact dermatitis 2018/2019. ( Johansen, JD; Werfel, T, 2019)
"Atopic dermatitis was the single most important risk factor for hand eczema."	2.46	The epidemiology of hand eczema in the general population--prevalence and main findings. ( Johansen, JD; Linneberg, A; Menné, T; Thyssen, JP, 2010)
"Nickel allergic contact dermatitis is a T-cell-mediated immune reaction which most commonly presents as a skin rash in areas exposed to nickel; however, more serious reactions to nickel in medical devices and more widespread eruptions to dietary nickel can occur."	2.45	Prevention of nickel allergy: the case for regulation? ( Dunnick, CA; Lu, LK; Warshaw, EM, 2009)
"Nickel allergy constitutes a serious health problem of modern societies."	2.44	[Mechanisms of nickel allergy]. ( Czarnobilska, E; Obtułowicz, K; Pietowska, J; Spiewak, R; Wsołek, K, 2007)
" Even though Ni exposure may be open, occluded, penetrating or oral, most dose-response studies in the literature concern single occluded application."	2.43	Experimental nickel elicitation thresholds--a review focusing on occluded nickel exposure. ( Fischer, LA; Johansen, JD; Menné, T, 2005)
" 9 studies were included in the final dose-response analysis, which divided the studies into a homogenous middle group of 5 studies and 2 groups of 2 studies with a higher and lower response frequency, respectively, described by logistic dose-response curves shifted in parallel."	2.43	Systemic contact dermatitis after oral exposure to nickel: a review with a modified meta-analysis. ( Jensen, CS; Johansen, JD; Menné, T, 2006)
"5 microgram/cm2/week is one below which a minority of nickel-allergic subjects will react, it is not safe in every nickel-sensitive individual."	2.39	Nickel dermatitis: how much nickel is safe? ( Gawkrodger, DJ, 1996)
"Although allergic contact dermatitis has been studied extensively, few studies addressed miRNA expression and their role in dendritic cell activation."	1.91	Role of miR-24-3p and miR-146a-5p in dendritic cells' maturation process induced by contact sensitizers. ( Corsini, E; Galbiati, V; Iulini, M; Lefevre, MA; Maddalon, A; Marinovich, M; Vocanson, M, 2023)
"Allergic contact dermatitis is diagnosed by patch testing along with patient history."	1.72	Patch Testing in an Allergy Clinic: Real-world Experience. ( Elbirt, D; Mahlab-Guri, K; Rosenberg-Bezalel, S, 2022)
"Lawsone was detected (0."	1.46	Monitoring of Lawsone, p-phenylenediamine and heavy metals in commercial temporary black henna tattoos sold in Turkey. ( Aktas Sukuroglu, A; Battal, D; Burgaz, S, 2017)
" Contact dermatitis and nickel allergy are more frequent in NCWS patients than in subjects with functional gastrointestinal disorders;furthermore, these patients had a very high frequency of cutaneous manifestations after wheat ingestion."	1.46	Contact Dermatitis Due to Nickel Allergy in Patients Suffering from Non-Celiac Wheat Sensitivity. ( Arini, A; Blasca, F; Bosco, L; Carroccio, A; Cavataio, F; D'Alcamo, A; Di Stefano, L; Fayer, F; Geraci, G; Iacobucci, R; Iacono, G; Mansueto, P; Soresi, M, 2017)
"Ethylene oxide allergy was not identified in any of the participants."	1.43	Prevalence of delayed-type and immediate-type hypersensitivity in healthcare workers with hand eczema. ( Agner, T; Garvey, LH; Ibler, KS; Jemec, GB, 2016)
"Allergic contact dermatitis is a leading cause of periorbital dermatitis."	1.40	Periorbital dermatitis in 4779 patients - patch test results during a 10-year period. ( Geier, J; John, SM; Landeck, L, 2014)
"Psoriasis is characterized by an apoptosis-resistant and metabolic active epidermis, while a hallmark for allergic contact dermatitis (ACD) is T cell-induced keratinocyte apoptosis."	1.40	Allergic contact dermatitis in psoriasis patients: typical, delayed, and non-interacting. ( Albanesi, C; Cavani, A; Eyerich, K; Eyerich, S; Garzorz, N; Grosber, M; Harlfinger, AT; Jaeger, T; Knapp, B; Mattii, M; Mempel, M; Nasorri, F; Pennino, D; Quaranta, M; Ring, J; Scarponi, C; Schmidt-Weber, CB; Schnopp, C; Theis, FJ, 2014)
"The bioavailability of the trace amounts of nickel in the particles was below the level needed to elicit an eczematous reaction in any of the nickel-sensitized individuals."	1.38	No skin reactions to mineral powders in nickel-sensitive subjects. ( Berg, M; Lodén, M; Neimert Carne, K; Nilsson, G; Parvardeh, M, 2012)
"Allergic contact dermatitis is preceded by a clinically silent phase of sensitisation."	1.37	Gene expression changes in peripheral blood mononuclear cells in occupational exposure to nickel. ( Avian, A; Bonin, S; Bovenzi, M; Larese, FF; Rui, F; Stanta, G; Trevisan, G, 2011)
"Allergic contact dermatitis was recorded in 27."	1.37	Dermatological screening and results of patch testing among Polish apprentice hairdressers. ( Chomiczewska, D; Kiec-Swierczynska, M; Krecisz, B, 2011)
"However, recently, allergic contact dermatitis has started to attract more interest as a cause of or contributor to eczema in children, and patch testing has been gaining in recognition as a useful diagnostic tool in this group."	1.37	Patch testing is a useful investigation in children with eczema. ( Athavale, P; Cork, MJ; Gawkrodger, DJ; Holden, CR; Messenger, AG; Moustafa, M, 2011)
" The elicitation doses were calculated, and fitted dose-response curves were drawn."	1.37	Can exposure limitations for well-known contact allergens be simplified? An analysis of dose-response patch test data. ( Fischer, LA; Johansen, JD; Menné, T; Voelund, A, 2011)
"Hand eczema is common in children, but affected children are seldom patch tested."	1.37	Patch testing in children with hand eczema. A 5-year multicentre study in Spain. ( Armario-Hita, JC; Borrego, L; Carrascosa, JM; De la Cuadra, J; Fernández-Redondo, V; García-Bravo, B; Giménez-Arnau, AM; González, R; Hervella, M; Sánchez-Pedreño, P; Silvestre, JF; Toledo, F, 2011)
"Octocrylene was by far the most frequent (photo)allergen in sun care products."	1.37	Non-fragrance allergens in specific cosmetic products. ( Boey, L; Claes, L; Drieghe, J; Goossens, A; Travassos, AR, 2011)
"A subgroup of patients with atopic eczema develops acute eczematous reactions to type I allergy-inducing agents such as pollen that clinically resemble type IV allergies induced by haptens like metal ions."	1.36	Comparative in situ topoproteome analysis reveals differences in patch test-induced eczema: cytotoxicity-dominated nickel versus pleiotrope pollen reaction. ( Behrendt, H; Böckelmann, R; Bonnekoh, B; Cavani, A; Eyerich, K; Foerster, S; Gollnick, H; Hofmeister, H; Huss-Marp, J; Pommer, AJ; Ring, J; Traidl-Hoffmann, C, 2010)
"Allergic contact dermatitis is a T cell-mediated immune response, which in its relapsing chronic form is of high socioeconomic impact."	1.36	Antigen-specific induction of osteopontin contributes to the chronification of allergic contact dermatitis. ( Iben, S; Kon, S; Liaw, L; Renkl, AC; Schulz, G; Seier, AM; Sindrilaru, A; Uebele, T; Uede, T; Weiss, JM, 2010)
"Allergic contact dermatitis is common in hairdressers because of their exposure to chemicals used in hair dyes and permanent wave solutions."	1.36	Hairdressers with dermatitis should always be patch tested regardless of atopy status. ( Mc Fadden, JP; O'Connell, RL; White, IR; White, JM, 2010)
"To examine and compare elicitation dose-response curves and elicitation thresholds in a polysensitized vs."	1.35	Patch test dose-response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals. ( Carlsen, BC; Fischer, LA; Johansen, JD; Menné, T; Sosted, H; Vølund, A, 2009)
"The aim was to develop an equation that could predict the response to an allergen in a ROAT based on the dose-response curve derived by patch testing."	1.35	The dose-response relationship between the patch test and ROAT and the potential use for regulatory purposes. ( Andersen, KE; Fischer, LA; Johansen, JD; Menné, T; Voelund, A, 2009)
"Allergic contact dermatitis is one of the most frequent dermatological problems affecting 7% of the general population."	1.35	Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. ( Baurecht, H; Behrendt, H; Heinrich, J; Illig, T; Klopp, N; Novak, N; Ring, J; Rodriguez, E; Schäfer, T; Wagenpfeil, S; Weidinger, S; Wichmann, E, 2008)
"Allergic contact dermatitis is increasing in childhood."	1.35	Patch test results in a Turkish paediatric population. ( Adisen, E; Onder, M, 2008)
"The dose-response relationships of the human immune system can be defined using the induction and elicitation of lymphocyte mediated allergic reactions to experimental contact sensitisers such as dinitrochlorobenzene (DNCB)."	1.33	Contact sensitisation and allergic contact dermatitis: immunobiological mechanisms. ( Friedmann, PS, 2006)
"The prevalence of allergic contact dermatitis is high."	1.33	[The most frequent allergens in allergic contact dermatitis]. ( Oppel, T; Schnuch, A, 2006)
" Moreover, these associations showed a significant dose-response relation, and they were independent of sex, age, and exposure to nickel, as reflected by a history of ear piercing."	1.32	Smoking might be a risk factor for contact allergy. ( Jørgensen, T; Linneberg, A; Madsen, F; Menné, T; Nielsen, NH, 2003)
"A case of oral allergy to dental alloys is presented, highlighting the interest of dosage of salivary nickel and of flow cytometry showing a selective CD4+ activation."	1.32	Allergy to nickel in dental alloys. ( Beaudouin, E; Burnel, D; Croizier, A; Moneret-Vautrin, DA; Sainte-Laudy, J, 2004)
"Since allergic contact dermatitis is a skin disorder in which an exaggerated T cell response of both types of T cell subsets can be observed, we used this disorder as a model to study the capacity of AID to suppress type-1 or type-2 T cell responses."	1.32	Identification of anti-inflammatory drugs according to their capacity to suppress type-1 and type-2 T cell profiles. ( Boorsma, DM; Bruynzeel, DP; Gibbs, S; Moed, H; Rustemeyer, T; Scheper, RJ; Stoof, TJ; von Blomberg, BM, 2004)
" Dose-response analyses were performed with dinitrobenzene sulfonic acid (DNBS) and formaldehyde formulated either in water, 1% L92, dimethyl sulfoxide (DMSO) or dimethyl formamide (DMF)."	1.31	Examination of a vehicle for use with water soluble materials in the murine local lymph node assay. ( Cruse, LW; Dearman, RJ; Gerberick, GF; Kimber, I; Ryan, CA; Skinner, RA, 2002)
" In the present study, the combined effect of an irritant and an allergen was evaluated in a dose-response designed experimental study."	1.31	Combined effects of irritants and allergens. Synergistic effects of nickel and sodium lauryl sulfate in nickel- sensitized individuals. ( Agner, T; Basketter, D; Johansen, JD; Menné, T; Overgaard, L; Vølund, A, 2002)
"Hand eczema is a common skin disease."	1.31	Clinical manifestations of hand eczema compared by etiologic classification and irritation reactivity to SLS. ( Ahn, SK; Choi, EH; Kang, YC; Lee, S, 2002)
"This may result in infection at the site and embedding of the earring."	1.31	The risks of ear piercing in children. ( Macgregor, DM, 2001)
" In the case of nickel chloride, sulfate, nitrate and acetate, material left on the skin surface, the depth-penetration profiles in the stratum corneum, and the dosage unaccounted for suggest the following conclusions: (a) Up to 24 h, most of the nickel dose applied remains on the skin surface or is adsorbed in the uppermost layers of the stratum corneum."	1.31	Human stratum corneum adsorption of nickel salts. Investigation of depth profiles by tape stripping in vivo. ( Anigbogu, A; Dreher, F; Hostýnek, JJ; Maibach, HI; Nakada, T; Schwindt, D, 2001)
"Allergic contact dermatitis is often caused by allergenic substances in products."	1.31	[Good opportunities to prevent contact eczema through legislation]. ( Lidén, C, 2002)
"Potassium dichromate was the most common allergen (20."	1.30	Common contact sensitizers in Chandigarh, India. A study of 200 patients with the European standard series. ( Chakrabarti, A; Sharma, VK, 1998)
" Thus, food intake and gastric emptying are of substantial significance for the bioavailability of nickel from aqueous solutions."	1.30	Absorption and retention of nickel from drinking water in relation to food intake and nickel sensitivity. ( Andersen, KE; Grandjean, P; Jørgensen, PJ; Nielsen, GD; Rasmussen, SN; Søderberg, U; Templeton, DM, 1999)
"50 patients with chronic fatigue syndrome (CFS) and 73 controls were patch tested with 8 metal allergens."	1.30	Chronic fatigue syndrome and nickel allergy. ( Evengård, B; Lindh, G; Marcusson, JA, 1999)
"Erythema caused by nickel contact hypersensitivity at each site was quantitated 72 h later with a reflectance erythema meter."	1.30	Low-dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans. ( Barnetson, RS; Damian, DL; Halliday, GM, 1999)
"The causes, diagnosis and treatment of necrotizing fasciitis are reviewed."	1.30	Cervical necrotizing fasciitis. ( Aimoni, C; Cilione, AR; Grandi, E; Lombardi, L; Merlo, R; Pastore, A, 1999)
"Our results suggest the reaction was a type I hypersensitivity reaction to ethylenediamine, but a nonimmune mechanism could not be excluded."	1.29	Immediate adverse reaction to aminophylline. ( Cuevas, M; de la Hoz, B; Lázaro, M; Pérez, C; Salazar, F; Tejedor, MA, 1993)
"Hand eczema was no more common in sensitized (1/22 = 4."	1.29	Ear piercing, and nickel and cobalt sensitization, in 520 young Swedish men doing compulsory military service. ( Bredberg, M; Fischer, T; Meijer, C; Widström, L, 1995)
"Allergic contact dermatitis is a delayed-type hypersensitivity reaction, secondary to hapten-specific T lymphocyte activation in sensitized individuals."	1.29	Establishment of nickel-specific T cell lines from patients with allergic contact dermatitis: comparison of different protocols. ( Bour, H; Demidem, A; Garrigue, JL; Nicolas, JF; Schmitt, D, 1994)
"Clioquinol is a potent inhibitor of nickel-induced hypersensitivity reactions and is feasible to use as a barrier ointment to block the allergenic effects of nickel in sensitive patients."	1.29	The inhibitory effects of topical chelating agents and antioxidants on nickel-induced hypersensitivity reactions. ( Friedmann, PS; Memon, AA; Molokhia, MM, 1994)
"The frequency difference of metal allergy in the dental group is statistically significant or close to significance for nickel sulfate, potassium dichromate, cobalt chloride, palladium chloride and gold sodium thiosulfate."	1.29	Contact allergies to nickel sulfate, gold sodium thiosulfate and palladium chloride in patients claiming side-effects from dental alloy components. ( Marcusson, JA, 1996)

Research

Studies (889)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Evaluation of Serum Biomarker Concentrations at the End of the Treatment (T1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (1.24)	18.7374
1990's	220 (24.75)	18.2507
2000's	301 (33.86)	29.6817
2010's	289 (32.51)	24.3611
2020's	68 (7.65)	2.80

Authors	Studies
Faybusovich, P	1
Lim, J	1
Ioffreda, MD	1
Al-Shaikhly, T	1
Lee, LJ	1
Koh, WL	1
Lim, SPR	1
Bach, RO	1
Svendsen, MT	1
Mose, KF	1
Bruze, M	29
Svedman, C	8
Andersen, KE	14
Blaser, P	2
Rothmund, B	1
Schmid, P	1
Stadler, R	1
Gemperle, C	1
McCombie, G	2
Wennervaldt, M	4
Ahlström, MG	11
Menné, T	77
Thyssen, JP	65
Johansen, JD	60
Oppel, E	1
Kapp, F	1
Böhm, AS	1
Pohl, R	1
Thomas, P	10
Summer, B	5
Nakazawa, S	1
Phadungsakswasdi, P	1
Kageyama, H	1
Fukuchi, K	1
Shimauchi, T	1
Fujiyama, T	1
Ito, T	1
Honda, T	1
Symanzik, C	3
Uter, W	22
Becker, SM	1
Skudlik, C	2
John, SM	4
Lahouel, I	1
Salah, NB	1
Machghoul, S	1
Belhadjali, H	1
Youssef, M	1
Zili, J	1
Roque Quintana, B	1
Falcón Hernández, A	1
Sagrera Guedes, A	1
Borrego, L	3
Peterson, MY	1
Hylwa, SA	2
Julander, A	14
Liljedahl, ER	1
Korres de Paula, H	1
Assarsson, E	1
Engfeldt, M	6
Littorin, M	1
Shobana Anto, C	1
Lidén, C	52
Broberg, K	1
Matsudate, Y	1
Wilkinson, SM	6
Aerts, O	1
Bauer, A	2
Brans, R	2
Buhl, T	2
Dickel, H	6
Dugonik, A	2
Filon, FL	1
Garcìa, PM	1
Giménez-Arnau, A	4
Patruno, C	4
Pesonen, M	2
Pónyai, G	2
Rustemeyer, T	14
Schubert, S	2
Schuttelaar, MA	2
Simon, D	2
Stingeni, L	4
Valiukevičienė, S	2
Weisshaar, E	2
Werfel, T	3
Gonçalo, M	8
Wang, G	1
Shen, T	1
Huang, X	1
Luo, Z	1
Tan, Y	1
He, G	1
Wang, Z	1
Li, P	1
Liu, X	2
Yu, X	1
Zhang, B	1
Zhou, H	2
Luo, X	1
Yang, X	1
Silverberg, JI	1
Patel, N	1
Warshaw, EM	10
DeKoven, JG	3
Belsito, DV	8
Atwater, AR	2
Houle, MC	1
Taylor, JS	7
Reeder, MJ	1
Zug, KA	4
Sasseville, D	4
DeLeo, VA	4
Pratt, MD	4
Fowler, JF	6
Maibach, HI	18
Wang, X	1
Hedberg, YS	1
Odnevall, I	1
De Graaf, NPJ	2
Roffel, S	3
Gibbs, S	7
Kleverlaan, CJ	7
Lopez Gonzalez, M	1
Feilzer, AJ	8
Bontkes, HJ	2
Alinaghi, F	2
Havmose, M	1
Zachariae, C	10
Zhu, M	1
Vinturache, A	1
Ding, G	1
Rosenberg-Bezalel, S	1
Elbirt, D	1
Mahlab-Guri, K	1
Kim, HH	1
Lee, GH	1
Pyo, GJ	1
Kwon, ES	1
Myung, KB	1
Cheong, SH	1
Giraldo-Tugores, M	1
Sanmartín-Fernández, M	1
Fernández-Lozano, C	1
Martínez-Botas, J	1
De-la-Hoz-Caballer, B	1
González-de-Olano, D	1
Matsubara, R	2
Kumagai, K	2
Nasu, K	1
Yoshizawa, T	1
Kitaura, K	2
Suzuki, M	1
Hamada, Y	2
Suzuki, R	2
Antelmi, A	2
Dahlin, J	4
Hopkins, K	1
Masjedi, K	3
Ahlborg, N	6
Brazão, C	1
Fernandes, S	1
Correia, T	1
Filipe, P	1
Baczynski, A	1
Waterman, C	1
Haber, R	1
Galbiati, V	1
Lefevre, MA	1
Maddalon, A	1
Vocanson, M	1
Iulini, M	1
Marinovich, M	1
Corsini, E	1
Chamani, S	1
Mobasheri, L	1
Rostami, Z	1
Zare, I	1
Naghizadeh, A	1
Mostafavi, E	1
Chan, CX	1
Hamann, CR	4
Zeng, Q	1
Wang, S	1
Cheng, L	1
Mu, J	1
Yang, J	1
Piesik, P	1
Han, C	1
de Gannes, G	1
Dutz, J	1
Rosholm Comstedt, L	2
Åkesson, A	2
Hindsén, M	12
Pontén, A	1
Isaksson, M	6
Lagrelius, M	4
Wahlgren, CF	3
Bradley, M	1
Melén, E	1
Kull, I	3
Bergström, A	2
Magrone, T	5
Russo, MA	4
Jirillo, E	4
Basso, P	1
Mauro, M	1
Miani, A	1
Belloni Fortina, A	4
Corradin, MT	2
Larese Filon, F	3
Drenovska, K	1
Shahid, M	1
Vassileva, S	1
Wootton, CI	1
Soukavong, M	1
Kidoikhammouan, S	1
Samountry, B	1
English, JSC	1
Mayxay, M	1
Filatova, D	1
Cherpak, C	1
An, N	1
Pourzal, S	1
Luccioli, S	1
Vukmanović, S	1
Tramontana, M	1
Bianchi, L	1
Hansel, K	1
Agostinelli, D	1
Koumaki, D	1
Koumaki, V	1
Rovithi, E	1
Boumpoucheropoulos, S	1
Katoulis, A	1
Bitados, P	1
Stefanidou, M	1
Evangelou, G	1
Krueger-Krasagakis, SE	1
Krasagakis, K	1
González, AG	1
De Las Vecillas, L	1
Montenegro, EA	1
Gutiérrez, JL	1
Tawfiq, M	1
Fernández, FR	1
Gergovska, M	1
Darlenski, R	2
Kazandjieva, J	2
Corazza, M	8
Bencivelli, D	1
Lauriola, MM	1
Scuderi, V	1
Borghi, A	2
Magrone, M	3
Romita, P	3
Massari, F	1
Foti, C	10
Pavesi, T	1
Moreira, JC	1
White, JML	2
Malik, A	1
Silverberg, NB	1
Pelletier, JL	2
Jacob, SE	10
Schneider, LC	1
Navarro-Triviño, FJ	1
Ruiz-Villaverde, R	1
García-Souto, F	1
Lorente-Lavirgen, AI	1
Bernabéu-Wittel, J	1
Rojas, C	1
Lorente, R	1
Alves, PB	1
Todo-Bom, A	1
Regateiro, FS	1
Shang, L	1
Deng, D	2
Wisgrill, L	1
Werner, P	1
Jalonen, E	1
Berger, A	1
Lauerma, A	2
Alenius, H	1
Fyhrquist, N	2
Bircher, AJ	7
Cooper, SM	1
Czarnecka-Operacz, M	1
Geier, J	12
Giménez-Arnau, AM	4
Johnston, GA	1
Mahler, V	2
Sanchez-Perez, J	5
Schuttelaar, MLA	2
Spiewak, R	8
White, IR	11
Wilkinson, M	3
Hagvall, L	2
Glas, B	2
Matura, M	5
Nyman, G	1
Stenberg, B	3
Ertugrul, A	1
Hizli Demirkale, Z	1
Bostanci, I	1
Blom, LH	1
Elrefaii, SA	1
Poulsen, LK	3
Moon, J	1
Reeder, M	1
Nádudvari, N	1
Németh, D	1
Sárdy, M	1
Temesvári, E	1
Tagka, A	1
Lambrou, GI	1
Matsopoulos, GK	1
Fytili, D	1
Mirkopoulou, D	1
Katsarou, A	1
Chatziioannou, A	1
Stratigos, A	1
Ashcroft, S	1
Howard, L	1
Patel, R	1
Churchill, T	1
Carras, E	1
Sadigh, D	1
Sullivan, R	1
Zetzmann, A	1
Ofenloch, R	1
Schliemann, S	1
Naldi, L	2
Svensson, Å	3
Elsner, P	5
Tsushima, F	1
Sakurai, J	1
Shimizu, R	1
Harada, H	1
Zhang, Y	1
Veldhuizen, R	1
Spiekstra, SW	1
Bontkes, H	1
Ljubojević Hadžavdić, S	1
Murtezani, I	1
Bradamante, M	1
Ilic, B	1
Linauskienė, K	2
Malinauskienė, L	3
Blažienė, A	2
Ormerod, E	1
Stone, N	1
Limone, BA	2
Bechara, R	3
Antonios, D	2
Azouri, H	2
Pallardy, M	4
Salvatore, R	2
Spagnoletta, A	2
Kieć-Świerczyńska, M	6
Świerczyńska-Machura, D	1
Chomiczewska-Skóra, D	3
Kręcisz, B	5
Walusiak-Skorupa, J	1
Verni, P	1
Mai, W	1
Lu, D	1
Chen, L	1
Kwon, WJ	1
Ko, JY	1
Ro, YS	1
Kim, MH	1
Kim, BS	1
Kim, HO	2
Nam, JH	1
Lee, GY	1
Park, MY	1
Son, SW	1
Yang, JM	2
Lee, DH	1
Lee, AY	1
Lee, JY	1
Chang, SE	1
Choi, HY	1
Park, EJ	1
Malmberg, P	1
Guttenberg, T	1
Ericson, MB	1
Ko, LN	1
Kroshinsky, D	1
Schalock, PC	1
Ivey, LA	1
Yfanti, I	1
Nosbaum, A	2
Berard, F	1
Nicolas, JF	2
Caiazzo, G	1
Di Caprio, R	1
Lembo, S	1
Raimondo, A	1
Scala, E	1
Balato, A	2
Fonacier, L	1
Noor, I	1
Ständer, S	1
Ofenloch, RF	1
Cazzaniga, S	1
Diepgen, TL	1
Aschenbeck, KA	1
Zirwas, MJ	4
Fransway, AF	4
Marks, JG	3
Mathias, T	2
Lang, DM	1
Fineman, SM	1
Khan, DA	1
Tilles, SA	1
Guccione, JΡ	1
du Vivier, AWP	1
Delimar, D	1
Bohaček, I	1
Paštar, Z	1
Lipozenčić, J	2
Yang, B	2
Sundquist, BK	2
Pasha, MA	2
Boyd, AH	1
Kawatani, Y	1
Kurobe, H	1
Nakamura, Y	1
Hori, T	1
Midander, K	7
Johnsen, CR	1
Maietti, E	1
Napolitano, M	1
Schena, D	2
Musumeci, ML	1
Micali, G	1
Kroona, L	1
Ahlgren, C	1
Warfvinge, G	1
Simonsen, AB	2
Foss-Skiftesvik, MH	1
Deleuran, M	2
Mortz, CG	8
Skov, L	9
Osterballe, M	2
Funding, A	1
Avnstorp, C	2
Andersen, BL	1
Vissing, S	2
Danielsen, A	1
Dufour, N	1
Nielsen, NH	14
Thormann, H	1
Sommerlund, M	3
Watts, TJ	1
Watts, S	1
Thursfield, D	1
Haque, R	1
Nixon, RL	1
Higgins, CL	1
Maor, D	1
Rajgopal Bala, H	1
Lalji, A	1
Heim, KE	2
Prasithirun, P	1
Kasemsarn, P	2
Boonchai, W	3
Zhang, AJ	1
Aalto-Korte, K	1
Suomela, S	1
Bennike, NH	1
Egeberg, A	1
Nabhan, M	1
Todberg, T	1
Krustrup, D	1
Nakasone, Y	1
Shigematsu, H	1
Suzuki, S	1
Satoh, M	1
Çifci, N	1
van der Bent, SAS	1
Berg, T	1
Karst, U	1
Sperling, M	1
Tammaro, A	5
Magri, F	2
Pigliacelli, F	2
Gelormini, E	1
Parisella Francesca, R	1
Chello, C	1
Persechino, S	4
Lian, BSY	1
McFadden, JP	5
Lee, SX	1
Strunk, M	1
Ruini, C	1
Wittmann, D	1
von Braunmühl, T	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Oral Human Administration of Red Grape Polyphenol in Nickel-mediated Allergic Contact Dermatitis: an in Vitro Study[NCT03902392]		50 participants (Actual)	Interventional	2018-04-16	Completed
Investigation of Nickel Sensitization After Percutaneous Implantation of Patent Foramen Ovale Occluder; a RandomizEd Trial.[NCT04713683]		100 participants (Anticipated)	Interventional	2020-12-10	Recruiting
Alteration of the microRNA-126 Expression: a Possible Mechanism in Allergic Contact Dermatitis to Nickel[NCT04365140]		15 participants (Actual)	Observational [Patient Registry]	2019-03-01	Completed
Evaluation of the Clinical Implication of Short Repeated Nickel Exposures[NCT03309215]		30 participants (Actual)	Interventional	2017-09-16	Completed
Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity[NCT02750735]		200 participants (Actual)	Observational	2001-01-31	Completed
Nickel Desensitization Using Topical Therapy[NCT01413477]		24 participants (Anticipated)	Interventional	2011-08-31	Not yet recruiting
A Randomized, Double-Blind, Vehicle-Controlled, Multicenter Trial to Assess the Safety and Efficacy of 0.1% Tacrolimus Ointment in the Treatment of Chronic Allergic Contact Dermatitis[NCT00667056]	Phase 4	98 participants (Actual)	Interventional	2004-07-31	Completed
Contact Allergens Causing Chronic Urticaria in a New England-Area Population[NCT00868036]		23 participants (Actual)	Observational	2008-12-31	Completed
Randomised Controlled Trial of the Alignment Efficiency and Coating Durability of Aesthetic Archwires[NCT03876184]		132 participants (Actual)	Interventional	2017-10-02	Completed
A Phase One, Open Label, Multi-Dose Study to Evaluate the Safety, Tolerability, and Biologic Effects of Three Doses of IW001 in Patients With Idiopathic Pulmonary Fibrosis (IPF)[NCT01199887]	Phase 1	30 participants (Actual)	Interventional	2010-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Serum biomarkers (IFN-γ, IL-17, IL-4, IL-10, PTX3 and NO) (pg/ml) in the same patients of both groups A and B whose received for 3 months Polyphenols (NATUR-OX) and placebo, respectively, were evaluated. To analyze serum biomarkers an ELISA method were used . (NCT03902392)
Timeframe: After 3 months (T1)

Evaluation of Serum Biomarker Concentrations at the Time of Enrollment (T0)

Intervention	pg/ml (Mean)
	IFN-γ (measurement unit: pg/ml)	IL-4 (measurement unit: pg/ml)	IL-17 (measurement unit: pg/ml)	IL-10 (measurement unit: pg/ml)	PTX3 (measurement unit: pg/ml)	NO concentration (measurement unit: pg/ml)
NATUR-OX Group (A)	10.41	79.57	51.36	25.67	365.3	1.381
Placebo Group (B)	17.29	112.2	100.6	11.19	455.9	2.619

At the time of enrollment (T0) concentrations of serum biomarkers (pg/ml) (IFN-γ, IL-17, IL-4, IL-10, PTX3 and NO) will be evaluated in patients of which, one group (A) will assume polyphenols (NATUR-OX ) while the other group (B) will assume placebo. Of note, from each group 7 spontaneously dropouts occurred. An ELISA method will be use to analyze and to assess serum biomarker concentrations. (NCT03902392)
Timeframe: Baseline (T0)

Intervention	pg/ml (Mean)
	IFN-γ (measurement unit: pg/ml)	IL-4 (measurement unit: pg/ml)	IL-17(measurement unit: pg/ml)	IL-10 (measurement unit: pg/ml)	PTX3 (measurement unit: pg/ml)	NO concentration (measurement unit: pg/ml)
NATUR-OX Group (A)	14.53	109.1	97.58	14.19	410.7	2.401
Placebo Group (B)	16.03	110.7	95.34	15.86	415.6	2.380

Article	Year
Contact allergy to metals in metalworkers: A systematic review and meta-analysis. Contact dermatitis, 2023, Volume: 88, Issue:1 Topics: Chromium; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Occupational; Humans; Male; Metals; Nick	2023
Heavy metals in contact dermatitis: A review. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2023, Volume: 79 Topics: CD8-Positive T-Lymphocytes; Chromium; Dermatitis, Allergic Contact; Humans; Irritants; Lead; Leukocy	2023
Impact of Heavy Metals on Host Cells: Special Focus on Nickel-Mediated Pathologies and Novel Interventional Approaches. Endocrine, metabolic & immune disorders drug targets, 2020, Volume: 20, Issue:7 Topics: Animals; Cell Physiological Phenomena; Dermatitis, Allergic Contact; Environmental Illness; Humans;	2020
Nickel and Skin: From Allergy to Autoimmunity. Endocrine, metabolic & immune disorders drug targets, 2020, Volume: 20, Issue:7 Topics: Animals; Autoimmune Diseases; Autoimmunity; Dermatitis, Allergic Contact; Humans; Nickel; Skin	2020
Mechanisms of Nickel-Induced Cell Damage in Allergic Contact Dermatitis and Nutritional Intervention Strategies. Endocrine, metabolic & immune disorders drug targets, 2020, Volume: 20, Issue:7 Topics: Antioxidants; Cell Death; Dermatitis, Allergic Contact; Diet; DNA Damage; Humans; Nickel; Oxidation-	2020
Effects of diet on skin sensitization by nickel, poison ivy, and sesquiterpene lactones. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 137 Topics: Dermatitis, Allergic Contact; Diet; Humans; Lactones; Nickel; Plant Extracts; Sesquiterpenes; Skin;	2020
Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment and Prevention Programs. Endocrine, metabolic & immune disorders drug targets, 2020, Volume: 20, Issue:7 Topics: Cosmetics; Dermatitis, Allergic Contact; Humans; Jewelry; Nickel; Occupational Exposure	2020
Nickel Allergy of the Skin and Beyond. Endocrine, metabolic & immune disorders drug targets, 2020, Volume: 20, Issue:7 Topics: Dermatitis, Allergic Contact; Diagnosis, Differential; Humans; Immune System Diseases; Nickel; Preva	2020
Nickel Allergic Contact Dermatitis: Identification, Treatment, and Prevention. Pediatrics, 2020, Volume: 145, Issue:5 Topics: Administration, Topical; Anti-Inflammatory Agents; Dermatitis, Allergic Contact; Environmental Expos	2020
The European nickel regulation and changes since its introduction. Contact dermatitis, 2017, Volume: 76, Issue:6 Topics: Consumer Product Safety; Dermatitis, Allergic Contact; European Union; Eyeglasses; Humans; Jewelry;	2017
Prevalence of nickel allergy in Europe following the EU Nickel Directive - a review. Contact dermatitis, 2017, Volume: 77, Issue:4 Topics: Adult; Dermatitis, Allergic Contact; Europe; Female; Humans; Male; Middle Aged; Nickel; Patch Tests;	2017
Contact dermatitis and patch testing for the allergist. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2018, Volume: 120, Issue:6 Topics: Adrenal Cortex Hormones; Allergens; Avoidance Learning; Balsams; Cosmetics; Dermatitis, Allergic Con	2018
Orthopedic and Cutaneous Reactions to Nickel after Total Hip Replacement. Acta dermatovenerologica Croatica : ADC, 2018, Volume: 26, Issue:1 Topics: Aged; Arthroplasty, Replacement, Hip; Dermatitis, Allergic Contact; Female; Humans; Hypersensitivity	2018
Prevalence of contact allergy in the general population: A systematic review and meta-analysis. Contact dermatitis, 2019, Volume: 80, Issue:2 Topics: Age Distribution; Anti-Infective Agents; Chromium; Cobalt; Coloring Agents; Dermatitis, Allergic Con	2019
Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment. Contact dermatitis, 2019, Volume: 81, Issue:4 Topics: Dermatitis, Allergic Contact; Diet; Europe; Humans; Jewelry; Nickel; Occupational Exposure; Patch Te	2019
Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment. Contact dermatitis, 2019, Volume: 81, Issue:4 Topics: Dermatitis, Allergic Contact; Diet; Europe; Humans; Jewelry; Nickel; Occupational Exposure; Patch Te	2019
Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment. Contact dermatitis, 2019, Volume: 81, Issue:4 Topics: Dermatitis, Allergic Contact; Diet; Europe; Humans; Jewelry; Nickel; Occupational Exposure; Patch Te	2019
Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment. Contact dermatitis, 2019, Volume: 81, Issue:4 Topics: Dermatitis, Allergic Contact; Diet; Europe; Humans; Jewelry; Nickel; Occupational Exposure; Patch Te	2019
Highlights in allergic contact dermatitis 2018/2019. Current opinion in allergy and clinical immunology, 2019, Volume: 19, Issue:4 Topics: Adhesives; Allergens; Dermatitis, Allergic Contact; Diabetes Mellitus; Europe; Female; Humans; Infus	2019
New findings in allergic contact dermatitis. Current opinion in allergy and clinical immunology, 2014, Volume: 14, Issue:5 Topics: Allergens; Biomedical Research; Dermatitis, Allergic Contact; Environmental Exposure; Food Preservat	2014
Systemic contact dermatitis to foods: nickel, BOP, and more. Current allergy and asthma reports, 2014, Volume: 14, Issue:10 Topics: Allergens; Balsams; Dermatitis, Allergic Contact; Food Hypersensitivity; Humans; Nickel; Trace Eleme	2014
Heavy metal (monoclonal) bands: a link between cutaneous T-cell lymphoma and contact allergy to potassium dichromate, nickel and cobalt? The Australasian journal of dermatology, 2015, Volume: 56, Issue:1 Topics: Aged; Chronic Disease; Cobalt; Dermatitis, Allergic Contact; Gene Rearrangement; Humans; Lymphoma, T	2015
Nickel hypersensitivity and orthodontic treatment: a systematic review and meta-analysis. Contact dermatitis, 2015, Volume: 73, Issue:1 Topics: Bias; Confounding Factors, Epidemiologic; Dermatitis, Allergic Contact; Humans; Nickel; Orthodontic	2015
[Dietetic interventions in allergic contact dermatitis--when are they reasonable?]. Przeglad lekarski, 2015, Volume: 72, Issue:12 Topics: Dermatitis, Allergic Contact; Food; Haptens; Humans; Nickel	2015
Patch-test results using Korean standard series: a 5-year retrospective review. The Journal of dermatological treatment, 2017, Volume: 28, Issue:3 Topics: Allergens; Dermatitis, Allergic Contact; Humans; Hydrocortisone; Nickel; Odds Ratio; Patch Tests; Ph	2017
New aspects in allergic contact dermatitis. Current opinion in allergy and clinical immunology, 2008, Volume: 8, Issue:5 Topics: Allergens; Asteraceae; Cosmetics; Dermatitis, Allergic Contact; Hair Dyes; Humans; Nickel; Nitriles;	2008
Prevalence of nickel hypersensitivity in orthodontic patients: a meta-analysis. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2008, Volume: 134, Issue:6 Topics: Body Piercing; Dermatitis, Allergic Contact; Humans; Nickel; Orthodontics, Corrective; Prevalence; R	2008
Prevention of nickel allergy: the case for regulation? Dermatologic clinics, 2009, Volume: 27, Issue:2 Topics: Consumer Product Safety; Dermatitis, Allergic Contact; Humans; Nickel; Prevalence; Risk Factors; Uni	2009
[Nickel allergy and orthodontics]. Nederlands tijdschrift voor tandheelkunde, 2009, Volume: 116, Issue:4 Topics: Child; Dermatitis, Allergic Contact; Humans; Hypersensitivity; Nickel; Orthodontic Appliances	2009
Systemic contact dermatitis. Dermatologic clinics, 2009, Volume: 27, Issue:3 Topics: Allergens; Asteraceae; Balsams; Dermatitis, Allergic Contact; Dermatology; Drug-Related Side Effects	2009
Pruritic rash. The Journal of family practice, 2009, Volume: 58, Issue:11 Topics: Administration, Topical; Adolescent; Allergens; Dermatitis, Allergic Contact; Diagnosis, Differentia	2009
The epidemiology of hand eczema in the general population--prevalence and main findings. Contact dermatitis, 2010, Volume: 62, Issue:2 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dermatitis, Allergic Contact; Dermatitis, Atopic;	2010
Nickel hypersensitivity: a clinical review and call to action. International journal of dermatology, 2010, Volume: 49, Issue:2 Topics: Body Piercing; Dermatitis, Allergic Contact; Female; Heart Valve Prosthesis; Humans; Hypersensitivit	2010
Cell phone allergic contact dermatitis: case report and review. Dermatology online journal, 2010, Jun-15, Volume: 16, Issue:6 Topics: Adult; Cell Phone; Chromium; Dermatitis, Allergic Contact; Facial Dermatoses; Female; Humans; Nickel	2010
The EU Nickel Directive revisited--future steps towards better protection against nickel allergy. Contact dermatitis, 2011, Volume: 64, Issue:3 Topics: Allergens; Consumer Product Safety; Dermatitis, Allergic Contact; European Union; Female; Humans; Ni	2011
Metal allergen of the 21st century--a review on exposure, epidemiology and clinical manifestations of palladium allergy. Contact dermatitis, 2011, Volume: 64, Issue:4 Topics: Dental Restoration, Permanent; Dermatitis, Allergic Contact; Humans; Jewelry; Nickel; Palladium; Pat	2011
Systemic nickel hypersensitivity and diet: myth or reality? European annals of allergy and clinical immunology, 2011, Volume: 43, Issue:1 Topics: Dermatitis, Allergic Contact; Diet; Food Analysis; Humans; Hypersensitivity; Nickel	2011
Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. Allergy, 2011, Volume: 66, Issue:9 Topics: Allergens; Animals; Dermatitis, Allergic Contact; Humans; Immunity, Innate; Inflammasomes; Ligands;	2011
Immunotherapy of allergic contact dermatitis. Immunotherapy, 2011, Volume: 3, Issue:8 Topics: Allergens; Animals; Dermatitis, Allergic Contact; Haptens; Humans; Immune Tolerance; Immunotherapy;	2011
[Current contact allergens]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2011, Volume: 62, Issue:10 Topics: Adolescent; Aldehydes; Allergens; Child; Chromates; Cross-Sectional Studies; Cyclohexenes; Dermatiti	2011
The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals. Part II. Contact dermatitis, 2012, Volume: 66 Suppl 1 Topics: Chromium; Consumer Product Safety; Cosmetics; Dermatitis, Allergic Contact; European Union; Humans;	2012
The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals. Part III. Contact dermatitis, 2012, Volume: 66 Suppl 1 Topics: Chromium; Consumer Product Safety; Cosmetics; Dermatitis, Allergic Contact; European Union; Humans;	2012
The many faces of nickel allergy. International journal of dermatology, 2012, Volume: 51, Issue:5 Topics: Adult; Dermatitis, Allergic Contact; Female; Humans; Male; Nickel; Risk Factors	2012
Coin exposure may cause allergic nickel dermatitis: a review. Contact dermatitis, 2013, Volume: 68, Issue:1 Topics: Dermatitis, Allergic Contact; Hand Dermatoses; Humans; Nickel; Numismatics; Occupational Diseases; O	2013
Nickel-induced hypersensitivity: etiology, immune reactions, prevention and therapy. Archives of dermatological research, 2002, Volume: 294, Issue:6 Topics: Dermatitis, Allergic Contact; Dermatitis, Occupational; Humans; Nickel; Occupational Exposure; Progn	2002
[Skin patch test with nickel sulphate--an attempt of broader interpretation of the results]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2002, Volume: 13, Issue:74 Topics: Dermatitis, Allergic Contact; Dose-Response Relationship, Immunologic; Environmental Exposure; Femal	2002
Allergy and skin diseases in musicians. European annals of allergy and clinical immunology, 2003, Volume: 35, Issue:2 Topics: Callosities; Coloring Agents; Dermatitis, Allergic Contact; Humans; Lip Diseases; Music; Nickel; Occ	2003
Decreasing allergic contact dermatitis frequency through dermatotoxicologic and epidemiologic based intervention? Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2003, Volume: 41, Issue:6 Topics: Allergens; Chromates; Dermatitis, Allergic Contact; Humans; Incidence; Nickel; Patch Tests; Perfume;	2003
[CONTACT ALLERGY CAUSED BY METALS AND OCCUPATIONAL DERMATOSES]. Minerva dermatologica, 1963, Volume: 38 Topics: Chemical Industry; Chromium; Cobalt; Copper; Dermatitis, Allergic Contact; Dermatitis, Contact; Derm	1963
Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium. Contact dermatitis, 2003, Volume: 49, Issue:1 Topics: Chromium; Cobalt; Consumer Product Safety; Dermatitis, Allergic Contact; Household Products; Humans;	2003
Contact dermatitis to metals. Dermatologic therapy, 2004, Volume: 17, Issue:4 Topics: Cobalt; Dermatitis, Allergic Contact; Female; Gold; Humans; Incidence; Male; Mercury; Metals; Nickel	2004
[Tolerance induction towards nickel. From animal model to humans]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2004, Volume: 55, Issue:11 Topics: Allergens; Animals; Dermatitis, Allergic Contact; Disease Models, Animal; Drug Tolerance; Humans; Im	2004
Contact dermatitis from the staples of neuroreflexotherapy. Contact dermatitis, 2004, Volume: 51, Issue:4 Topics: Allergens; Dermatitis, Allergic Contact; Female; Humans; Low Back Pain; Middle Aged; Nickel; Patch T	2004
Nickel allergy versus nickel tolerance: can oral uptake of nickel protect from sensitization? Journal of environmental monitoring : JEM, 2004, Volume: 6, Issue:12 Topics: Administration, Oral; Animals; Dermatitis, Allergic Contact; Drug Tolerance; Humans; Hypersensitivit	2004
Cutaneous and oral eruption from oral exposure to nickel in dental braces. Dermatitis : contact, atopic, occupational, drug, 2004, Volume: 15, Issue:3 Topics: Child; Dermatitis, Allergic Contact; Exanthema; Humans; Lip Diseases; Male; Mouth Diseases; Nickel;	2004
Experimental nickel elicitation thresholds--a review focusing on occluded nickel exposure. Contact dermatitis, 2005, Volume: 52, Issue:2 Topics: Allergens; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Humans; Nickel; No-Observ	2005
Breaking tolerance to nickel. Toxicology, 2005, Apr-15, Volume: 209, Issue:2 Topics: Animals; CD8-Positive T-Lymphocytes; Dermatitis, Allergic Contact; Humans; Nickel	2005
The baboon syndrome--report of two first cases in Poland. Contact dermatitis, 2005, Volume: 52, Issue:5 Topics: Adrenal Cortex Hormones; Adult; Aged; Allergens; Dermatitis, Allergic Contact; Female; Follow-Up Stu	2005
Systemic contact dermatitis after oral exposure to nickel: a review with a modified meta-analysis. Contact dermatitis, 2006, Volume: 54, Issue:2 Topics: Administration, Oral; Allergens; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Foo	2006
Interactions of chemicals and metal ions with proteins and role for immune responses. Mini reviews in medicinal chemistry, 2006, Volume: 6, Issue:3 Topics: Allergens; Animals; Dermatitis, Allergic Contact; Haptens; Humans; Hypersensitivity; Ions; Metals; N	2006
Itchy rash near the navel. The Journal of family practice, 2007, Volume: 56, Issue:2 Topics: Administration, Topical; Child; Clothing; Dermatitis, Allergic Contact; Exanthema; Family Practice;	2007
Contact allergy epidemics and their controls. Contact dermatitis, 2007, Volume: 56, Issue:4 Topics: Chromium; Dermatitis, Allergic Contact; Formaldehyde; Humans; Nickel; Nitriles; Phenylenediamines; R	2007
Oral tolerance to contact allergens: a common occurrence? A review. Contact dermatitis, 2007, Volume: 56, Issue:5 Topics: Administration, Oral; Allergens; Animals; Dermatitis, Allergic Contact; Food Preservatives; Humans;	2007
Genetics of nickel allergic contact dermatitis. Dermatitis : contact, atopic, occupational, drug, 2007, Volume: 18, Issue:3 Topics: Allergens; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Tr	2007
[Mechanisms of nickel allergy]. Przeglad lekarski, 2007, Volume: 64, Issue:7-8 Topics: Antigen-Presenting Cells; Dermatitis, Allergic Contact; Humans; Hypersensitivity; Nickel; Risk Facto	2007
Quantitative aspects of nickel dermatitis. Sensitization and eliciting threshold concentrations. The Science of the total environment, 1994, Jun-06, Volume: 148, Issue:2-3 Topics: Dermatitis, Allergic Contact; Environmental Exposure; Female; Humans; Male; Nickel	1994
The molecular basis of metal recognition by T cells. The Journal of investigative dermatology, 1994, Volume: 102, Issue:4 Topics: Antibody Formation; Dermatitis, Allergic Contact; Haptens; Histocompatibility Antigens Class II; Hum	1994
All the things I knew were true about contact dermatitis that aren't. Cutis, 1993, Volume: 52, Issue:5 Topics: Adrenal Cortex Hormones; Dermatitis, Allergic Contact; Friction; Humans; Nickel; Orthodontic Applian	1993
Nickel sensitivity and the implantation of orthopaedic prostheses. Contact dermatitis, 1993, Volume: 28, Issue:5 Topics: Dermatitis, Allergic Contact; Hip Prosthesis; Humans; Nickel; Prostheses and Implants; Prosthesis Fa	1993
Nickel, cobalt and chromium in consumer products: a role in allergic contact dermatitis? Contact dermatitis, 1993, Volume: 28, Issue:1 Topics: Chromium; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Occupational; Dose-Response Relationship	1993
[Contact dermatitis following cardiac pacemaker implantation]. Archives des maladies du coeur et des vaisseaux, 1996, Volume: 89, Issue:2 Topics: Aged; Dermatitis, Allergic Contact; Eczema; Female; Humans; Nickel; Pacemaker, Artificial; Skin Test	1996
The immunology of nickel-induced allergic contact dermatitis. Asian Pacific journal of allergy and immunology, 1995, Volume: 13, Issue:2 Topics: Animals; Antigen-Presenting Cells; Cell Adhesion Molecules; Cytokines; Dermatitis, Allergic Contact;	1995
Nickel dermatitis: how much nickel is safe? Contact dermatitis, 1996, Volume: 35, Issue:5 Topics: Alloys; Consumer Product Safety; Dermatitis, Allergic Contact; Dermatitis, Occupational; Environment	1996
New developments in jewellery and dental materials. Contact dermatitis, 1998, Volume: 39, Issue:2 Topics: Alloys; Cobalt; Dental Materials; Dental Prosthesis; Dermatitis, Allergic Contact; Humans; Nickel; P	1998
[Contact allergy to nickel]. Medycyna pracy, 1998, Volume: 49, Issue:3 Topics: Adult; Dermatitis, Allergic Contact; Environmental Exposure; Environmental Monitoring; Epidemiologic	1998
Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview. Allergy, 2000, Volume: 55, Issue:2 Topics: Cross Reactions; Dermatitis, Allergic Contact; Haptens; Humans; Metals; Nickel; Patch Tests; Skin; T	2000
Differences between the sexes with regard to work-related skin disease. Contact dermatitis, 2000, Volume: 43, Issue:2 Topics: Dermatitis, Allergic Contact; Dermatitis, Irritant; Dermatitis, Occupational; Female; Hand Dermatose	2000
An overview of the efficacy of topical corticosteroids in experimental human nickel contact dermatitis. Contact dermatitis, 2000, Volume: 43, Issue:6 Topics: Administration, Topical; Allergens; Anti-Inflammatory Agents; Colorimetry; Controlled Clinical Trial	2000
Legislative and preventive measures related to contact dermatitis. Contact dermatitis, 2001, Volume: 44, Issue:2 Topics: Allergens; Cosmetics; Dermatitis, Allergic Contact; Europe; Humans; Legislation, Medical; Nickel	2001
Is contact allergy in man lifelong? An overview of patch test follow-ups. Contact dermatitis, 2001, Volume: 44, Issue:3 Topics: Antirheumatic Agents; Cobalt; Dermatitis, Allergic Contact; Follow-Up Studies; Gold Sodium Thiosulfa	2001
Effects of low-dose ultraviolet radiation on in vivo human cutaneous recall responses. The Australasian journal of dermatology, 2001, Volume: 42, Issue:3 Topics: Allergens; Dermatitis, Allergic Contact; Dose-Response Relationship, Radiation; Humans; Hypersensiti	2001
[Allergy in women]. Allergie et immunologie, 2001, Volume: 33, Issue:10 Topics: Cosmetics; Cross Reactions; Dermatitis, Allergic Contact; Female; Humans; Life Style; Male; Metals,	2001

Article	Year
A comparison of patch testing with nickel sulfate in TRUE Test and in petrolatum at 2.5% and 5% concentrations. Contact dermatitis, 2022, Volume: 86, Issue:3 Topics: Dermatitis, Allergic Contact; Humans; Nickel; Patch Tests; Petrolatum	2022
Corticosteroid application prior to nickel exposure prevents contact dermatitis in sensitized individuals. Contact dermatitis, 2020, Volume: 82, Issue:3 Topics: Administration, Cutaneous; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Dermatitis, Allergic	2020
Red Grape Polyphenol Oral Administration Improves Immune Response in Women Affected by Nickel-Mediated Allergic Contact Dermatitis. Endocrine, metabolic & immune disorders drug targets, 2021, Volume: 21, Issue:2 Topics: Administration, Oral; Adult; Dermatitis, Allergic Contact; Double-Blind Method; Female; Humans; Immu	2021
Does clinical testing support the current guidance definition of prolonged contact for nickel allergy? Contact dermatitis, 2018, Volume: 79, Issue:6 Topics: Adult; Dermatitis, Allergic Contact; Double-Blind Method; European Union; Female; Humans; Male; Midd	2018
The effect of anti-IL-17 treatment on the reaction to a nickel patch test in patients with allergic contact dermatitis. International journal of dermatology, 2019, Volume: 58, Issue:3 Topics: Adult; Aged; Allergens; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biopsy; Dermatiti	2019
New UK nickel-plated steel coins constitute an increased allergy and eczema risk. Contact dermatitis, 2013, Volume: 68, Issue:6 Topics: Copper; Dermatitis, Allergic Contact; Dermatitis, Contact; Environmental Exposure; Environmental Pol	2013
Nickel oral hyposensitization in patients with systemic nickel allergy syndrome. Annals of medicine, 2014, Volume: 46, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Dermatitis, Allergic Contact; Desensitization, Immunologic;	2014
Fast itch relief in an experimental model for methylprednisolone aceponate topical corticosteroid activity, based on allergic contact eczema to nickel sulphate. Journal of the European Academy of Dermatology and Venereology : JEADV, 2014, Volume: 28, Issue:10 Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Dermatitis, Allergic Con	2014
Evaluation of a Self-Test Device Used in Allergic Contact Dermatitis. Skin pharmacology and physiology, 2015, Volume: 28, Issue:5 Topics: Allergens; Dermatitis, Allergic Contact; Female; Humans; Male; Nickel; Patch Tests; Perfume; Self Ca	2015
Comparing reliabilities of strip and conventional patch testing. Contact dermatitis, 2017, Volume: 76, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Dermatitis, Allergic Contact; Female; Humans; Male; Middle Aged; Nic	2017
Evaluation of the effect of the specific CCR1 antagonist CP-481715 on the clinical and cellular responses observed following epicutaneous nickel challenge in human subjects. Contact dermatitis, 2008, Volume: 59, Issue:4 Topics: Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans;	2008
Increased sensitivity of patch testing by standardized tape stripping beforehand: a multicentre diagnostic accuracy study. Contact dermatitis, 2010, Volume: 62, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Dermatitis, Allergic Contact; Female; Humans;	2010
Association of CD69 up-regulation on CD4+ Cla+ T cells versus patch test, strip patch test and clinical history in nickel sensitization. European journal of medical research, 2010, Volume: 15 Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4-Positive T-Lymphocytes; Derm	2010
Prevention of immunosuppression by sunscreens in humans is unrelated to protection from erythema and dependent on protection from ultraviolet a in the face of constant ultraviolet B protection. The Journal of investigative dermatology, 2003, Volume: 121, Issue:1 Topics: Adolescent; Adult; Aged; Dermatitis, Allergic Contact; Dose-Response Relationship, Radiation; Erythe	2003
Tacrolimus ointment 0.1% in the treatment of nickel-induced allergic contact dermatitis. Journal of the American Academy of Dermatology, 2003, Volume: 49, Issue:3 Topics: Administration, Topical; Adult; Cross-Over Studies; Dermatitis, Allergic Contact; Dose-Response Rela	2003
Experimental systemic contact dermatitis from nickel: a dose-response study. Contact dermatitis, 2003, Volume: 49, Issue:3 Topics: Administration, Oral; Adult; Aged; Allergens; Dermatitis, Allergic Contact; Dose-Response Relationsh	2003
Correlation between laser Doppler perfusion imaging and visual scoring of patch test sites in subjects with experimentally induced allergic and irritant contact reactions. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2004, Volume: 10, Issue:1 Topics: Dermatitis, Allergic Contact; Humans; Irritants; Laser-Doppler Flowmetry; Nickel; Patch Tests	2004
Topical tacrolimus 0.1% ointment (protopic) reverses nickel contact dermatitis elicited by allergen challenge to a similar degree to mometasone furoate 0.1% with greater suppression of late erythema. Contact dermatitis, 2003, Volume: 49, Issue:4 Topics: Administration, Topical; Adult; Anti-Allergic Agents; Dermatitis, Allergic Contact; Dose-Response Re	2003
The effect of the topical application of different pentoxifylline concentrations on the patch test results of nickel-sensitive patients. International journal of dermatology, 2004, Volume: 43, Issue:4 Topics: Administration, Topical; Adolescent; Adult; Aged; Dermatitis, Allergic Contact; Dermatologic Agents;	2004
Oral prednisone suppresses allergic but not irritant patch test reactions in individuals hypersensitive to nickel. Contact dermatitis, 2004, Volume: 50, Issue:5 Topics: Administration, Oral; Allergens; Anti-Inflammatory Agents; Cross-Over Studies; Dermatitis, Allergic	2004
Effects of pretreatment with a urea-containing emollient on nickel allergic skin reactions. Acta dermato-venereologica, 2005, Volume: 85, Issue:1 Topics: Adolescent; Adult; Aged; Dermatitis, Allergic Contact; Electric Impedance; Emollients; Female; Human	2005
Macro-video documentation patch tests. Contact dermatitis, 2005, Volume: 52, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Allergens; Dermatitis, Allergic Contact; Female; Humans; Irritants;	2005
Safety of blocking vascular adhesion protein-1 in patients with contact dermatitis. Basic & clinical pharmacology & toxicology, 2005, Volume: 96, Issue:6 Topics: Adult; Amine Oxidase (Copper-Containing); Animals; Antibodies, Monoclonal; Cell Adhesion Molecules;	2005
Cross-reactivity between nickel and palladium demonstrated by systemic administration of nickel. Contact dermatitis, 2005, Volume: 53, Issue:1 Topics: Administration, Oral; Adult; Allergens; Cobalt; Cross Reactions; Dermatitis, Allergic Contact; Dose-	2005
A prospective randomized clinical trial of 0.1% tacrolimus ointment in a model of chronic allergic contact dermatitis. Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Dermatitis, Allergic Contact; Double-Bl	2006
Positive patch test reactions to nickel sulphate are not modified by neighbouring negative fragrance patch tests. A multicenter-study by the German contact dermatitis research group. Acta dermato-venereologica, 2006, Volume: 86, Issue:4 Topics: Allergens; Dermatitis, Allergic Contact; Double-Blind Method; Female; Humans; Male; Middle Aged; Nic	2006
Role of contact sensitization in chronic urticaria. Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:1 Topics: Adolescent; Adult; Aged; Allergens; Chronic Disease; Cosmetics; Dermatitis, Allergic Contact; Deterg	2007
A double-blind randomized placebo-controlled pilot study comparing topical immunomodulating agents and corticosteroids for treatment of experimentally induced nickel contact dermatitis. Dermatitis : contact, atopic, occupational, drug, 2007, Volume: 18, Issue:1 Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Adult; Allergens; Clobetasol; Dermatitis, Allerg	2007
Dose per unit area - a study of elicitation of nickel allergy. Contact dermatitis, 2007, Volume: 56, Issue:5 Topics: Adult; Aged; Allergens; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Female; Huma	2007
Nickel allergy: relationship between patch test and repeated open application test thresholds. The British journal of dermatology, 2007, Volume: 157, Issue:4 Topics: Adolescent; Adult; Aged; Allergens; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug;	2007
Nickel/magnesium interactions in nickel-sensitive patients. Contact dermatitis, 1995, Volume: 33, Issue:1 Topics: Adult; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Female; Humans; Irritants; Ma	1995
Triclosan reduces the clinical symptoms of the allergic patch test reaction (APR) elicited with 1% nickel sulphate in sensitised patients. Journal of clinical periodontology, 1995, Volume: 22, Issue:6 Topics: Allergens; Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Allerg	1995
The influence of patch tests with clobetasol propionate on adjacent patch test reactions. Contact dermatitis, 1995, Volume: 32, Issue:3 Topics: Clobetasol; Dermatitis, Allergic Contact; Drug Interactions; Ethanol; Humans; Nickel; Patch Tests; S	1995
Hyposensitization in nickel allergic contact dermatitis: clinical and immunologic monitoring. Journal of the American Academy of Dermatology, 1995, Volume: 32, Issue:4 Topics: Adult; Cell Division; Dermatitis, Allergic Contact; Desensitization, Immunologic; Female; Follow-Up	1995
Low nickel diet: an open, prospective trial. Journal of the American Academy of Dermatology, 1993, Volume: 29, Issue:6 Topics: Adult; Dermatitis, Allergic Contact; Female; Follow-Up Studies; Humans; Male; Nickel; Patch Tests; P	1993
Dose-response testing with nickel sulphate using the TRUE test in nickel-sensitive individuals. Multiple nickel sulphate patch-test reactions do not cause an 'angry back'. The British journal of dermatology, 1993, Volume: 129, Issue:1 Topics: Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Humans; Irritants; Nickel; Patch Tes	1993
Comparison of 2 different methods for enhancing the reaction to nickel sulfate patch tests in negative reactors. Contact dermatitis, 1996, Volume: 35, Issue:5 Topics: Adult; Dermatitis, Allergic Contact; False Negative Reactions; Female; Humans; Nickel; Patch Tests;	1996
Cutaneous reactivity of the hands in nickel-sensitive patients with hand eczema. Contact dermatitis, 1998, Volume: 38, Issue:6 Topics: Adolescent; Adult; Aged; Back; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Eczem	1998
Objective assessment of nickel sulfate patch test reactions with laser Doppler perfusion imaging. Contact dermatitis, 1998, Volume: 39, Issue:3 Topics: Adult; Aged; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Female; Humans; Irritan	1998
Topically applied pentoxifylline has no effect on allergic patch responses. Journal of the American Academy of Dermatology, 1998, Volume: 39, Issue:6 Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents; Dermatitis, Allergic Contact; Dermatolog	1998
The flare-up reactions after systemic provocation in contact allergy to nickel and gold. Contact dermatitis, 1999, Volume: 40, Issue:4 Topics: Acute-Phase Proteins; Administration, Oral; Adult; Aged; Allergens; Antigens, CD; Body Temperature;	1999
In vivo nickel allergic contact dermatitis: human model for topical therapeutics. Contact dermatitis, 1999, Volume: 40, Issue:4 Topics: Administration, Cutaneous; Adult; Blood Flow Velocity; Dermatitis, Allergic Contact; Dermatologic Ag	1999
ZnSO4 treatment of NiSO4-positive patients. Contact dermatitis, 1999, Volume: 40, Issue:5 Topics: Administration, Oral; Adult; Astringents; Dermatitis, Allergic Contact; Female; Humans; Male; Nickel	1999
Individual variation in nickel patch test reactivity. American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 1999, Volume: 10, Issue:2 Topics: Adult; Age Factors; Dermatitis, Allergic Contact; Female; Humans; Menopause; Menstrual Cycle; Middle	1999
Effects of repeated skin exposure to low nickel concentrations: a model for allergic contact dermatitis to nickel on the hands. The British journal of dermatology, 1999, Volume: 141, Issue:4 Topics: Adult; Aged; Case-Control Studies; Dermatitis, Allergic Contact; Dermatitis, Occupational; Double-Bl	1999
Nickel-induced cytokine production from mononuclear cells in nickel-sensitive individuals and controls. Cytokine profiles in nickel-sensitive individuals with nickel allergy-related hand eczema before and after nickel challenge. Archives of dermatological research, 2000, Volume: 292, Issue:6 Topics: Cytokines; Dermatitis, Allergic Contact; Dermatitis, Occupational; Double-Blind Method; Hand Dermato	2000
Dual effects of CGRP-antagonist on allergic contact dermatitis in human skin. Contact dermatitis, 2000, Volume: 43, Issue:3 Topics: Adult; Aged; Calcitonin Gene-Related Peptide; Dermatitis, Allergic Contact; Dermatitis, Contact; Der	2000
Lymphocyte subset changes in blood and gastrointestinal mucosa after oral nickel challenge in nickel-sensitized women. Contact dermatitis, 2000, Volume: 43, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Allergens; Basement Membrane; Biopsy; CD4-Positive T-Lympho	2000
Multicentre study of allergic contact cheilitis from toothpastes. Contact dermatitis, 2000, Volume: 43, Issue:4 Topics: Adolescent; Adult; Aged; Allergens; Caustics; Cheilitis; Dermatitis, Allergic Contact; Eczema; Femal	2000
A cream containing the chelator DTPA (diethylenetriaminepenta-acetic acid) can prevent contact allergic reactions to metals. Contact dermatitis, 2001, Volume: 44, Issue:4 Topics: Chelating Agents; Chromium; Cobalt; Copper; Dermatitis, Allergic Contact; Female; Humans; Male; Meta	2001
Flare-up reactions after oral challenge with nickel in relation to challenge dose and intensity and time of previous patch test reactions. Journal of the American Academy of Dermatology, 2001, Volume: 44, Issue:4 Topics: Administration, Oral; Adult; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Female;	2001
Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis. Contact dermatitis, 2001, Volume: 44, Issue:6 Topics: Adult; Dermatitis, Allergic Contact; Dermatitis, Irritant; Emollients; Female; Humans; Nickel; Skin;	2001
Repetitive usage testing with budesonide in experimental nickel--allergic contact dermatitis in individuals hypersensitive to budesonide. The British journal of dermatology, 2001, Volume: 145, Issue:1 Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Budesonide; Dermatitis, Allergic Con	2001
Combination therapy improves the recovery of the skin barrier function: an experimental model using a contact allergy patch test combined with TEWL measurements. Dermatology (Basel, Switzerland), 2001, Volume: 202, Issue:4 Topics: Administration, Cutaneous; Adult; Allantoin; Allergens; Androstadienes; Anti-Inflammatory Agents; De	2001
Efficacy of topical corticosteroids in nickel-induced contact allergy. Clinical and experimental dermatology, 2002, Volume: 27, Issue:1 Topics: Administration, Cutaneous; Adult; Androstadienes; Anti-Inflammatory Agents; Dermatitis, Allergic Con	2002

nickel and Dermatitis, Allergic Contact