nickel has been researched along with Cell Transformation, Neoplastic in 116 studies
Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
nickel ion : A nickel atom having a net electric charge.
nickel atom : Chemical element (nickel group element atom) with atomic number 28.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present review indicates that arsenic, cadmium, chromium, nickel and probably beryllium are associated with malignant neoplasms in humans." | 4.77 | Trace metals and neoplasia. ( Sky-Peck, HH, 1986) |
| "Chronic lung inflammation is accepted as being associated with the development of lung cancer caused by nickel exposure." | 3.83 | Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells. ( Che, X; Chen, LC; Gao, J; Gu, J; Huang, C; Huang, H; Jin, H; Li, J; Li, Y; Lyu, J; Xie, Q; Zhang, L; Zhu, J, 2016) |
| "Transfer of a normal Chinese hamster X chromosome (carried in a mouse A9 donor cell line) to a nickel-transformed Chinese hamster cell line with an Xq chromosome deletion resulted in senescense of these previously immortal cells." | 3.68 | Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control. ( Annab, L; Barrett, JC; Bhamra, RK; Cohen, MD; Conway, K; Costa, M; Klein, CB; Lin, XH; Wang, XW, 1991) |
| "Most cancers have an occupational, viral, nutritional, behavioral or iatrogenic etiology." | 2.42 | Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings. ( Beaubier, J; Chiu, A; Chiu, N; Katz, AJ; Shi, X, 2004) |
| " A model exists that relates respiratory carcinogenic potential to the bioavailability of nickel ion at nuclear sites within respiratory target cells." | 2.41 | Respiratory carcinogenicity assessment of soluble nickel compounds. ( Oller, AR, 2002) |
| "At first, dose-response (0, 10, 20, and 30 μg/mL) and time-response (0, 3, 6, 12, and 24 h) studies were performed in immortalized normal human bronchial epithelial cells BEAS-2B to observe the effects of Nano-Ni on DNA damage response (DDR)-associated proteins and the HIF-1α/miR-210/Rad52 pathway by real-time PCR or Western blot." | 1.62 | Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway. ( Mo, L; Mo, Y; Yuan, J; Zhang, Q; Zhang, Y, 2021) |
| "Cadmium and nickel have been classified as carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer." | 1.39 | Identification of molecular candidates and interaction networks via integrative toxicogenomic analysis in a human cell line following low-dose exposure to the carcinogenic metals cadmium and nickel. ( Kim, IS; Koedrith, P; Kwon, JY; Park, KS; Seo, YR; Weon, JI, 2013) |
| "1)% methylated CpG were observed in cells treated with NiS for three times at dosage of 0." | 1.36 | [Genome DNA hypomethylation in the process of crystalline nickel-induced cell malignant transformation]. ( Gong, CM; Ji, WD; Ke, YB; Liu, JJ; Tao, GH; Yang, LQ; Zhang, WJ; Zhou, L; Zhuang, ZX, 2010) |
| " The frequency of transformation showed a dose-response relation at the experimental concentrations." | 1.31 | [Protection of beta-carotene and vitamin C on the transformation of human lung fibroblasts cell induced by nickel sesquioxide]. ( Liu, Y; Zhang, J; Zhu, S, 2000) |
| "In summary, dose-response relationships have been demonstrated for Ni3S2 carcinogenesis in rats and hamsters and for transformation of Syrian hamster fetal cells by Ni3S2 in vitro." | 1.27 | Organ and species specificity in nickel subsulfide carcinogenesis. ( Sunderman, FW, 1983) |
| " Recent experiments with Ni and Cr compounds, and freshly produced welding fumes, which contain Ni and Cr, demonstrate a strong dependence of the distribution of these metals on oxidation state, solubility, bioavailability and toxicity as measured by in-vitro bioassay, depending on the collection, storage and analytical technique." | 1.27 | Indicators of matrix dependent variation in effective dose for chromium and nickel aerosol exposures. ( Stern, RM, 1988) |
| "Malignant testicular neoplasms developed in 16 of 19 rats within 20 months after an injection of 10 mg of Ni3S2." | 1.26 | Induction of testicular sarcomas in Fischer rats by intratesticular injection of nickel subsulfide. ( Allpass, PR; Damjanov, I; Mitchell, JM; Sunderman, FW, 1978) |
| " A dose-response relationship was found between the concentration of alpha Ni3S2 and the incidence of morphological transformation." | 1.26 | Induction of sarcomas in nude mice by implantation of Syrian hamster fetal cells exposed in vitro to nickel subsulfide. ( Allpass, PR; Costa, M; Gondos, B; Nye, JS; Sunderman, FW, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (42.24) | 18.7374 |
| 1990's | 12 (10.34) | 18.2507 |
| 2000's | 35 (30.17) | 29.6817 |
| 2010's | 17 (14.66) | 24.3611 |
| 2020's | 3 (2.59) | 2.80 |
| Authors | Studies |
|---|---|
| Mo, Y | 1 |
| Zhang, Y | 2 |
| Yuan, J | 3 |
| Mo, L | 1 |
| Zhang, Q | 3 |
| Kang, YT | 1 |
| Hsu, WC | 1 |
| Ou, CC | 1 |
| Tai, HC | 1 |
| Hsu, HT | 1 |
| Yeh, KT | 2 |
| Ko, JL | 2 |
| Zhu, Y | 1 |
| Chen, QY | 2 |
| Jordan, A | 1 |
| Sun, H | 3 |
| Roy, N | 1 |
| Costa, M | 28 |
| Son, YO | 3 |
| Pratheeshkumar, P | 3 |
| Divya, SP | 1 |
| Zhang, Z | 3 |
| Shi, X | 5 |
| Scanlon, SE | 1 |
| Scanlon, CD | 1 |
| Hegan, DC | 1 |
| Sulkowski, PL | 1 |
| Glazer, PM | 1 |
| Wu, CH | 1 |
| Hsiao, YM | 1 |
| Tsou, TC | 1 |
| Chen, CY | 1 |
| Wu, MF | 1 |
| Zhang, J | 4 |
| Zhou, Y | 1 |
| Ma, L | 1 |
| Huang, S | 1 |
| Wang, R | 1 |
| Gao, R | 1 |
| Wu, Y | 1 |
| Shi, H | 1 |
| Crowder, SW | 1 |
| Horton, LW | 1 |
| Lee, SH | 2 |
| McClain, CM | 1 |
| Hawkins, OE | 1 |
| Palmer, AM | 1 |
| Bae, H | 1 |
| Richmond, A | 1 |
| Sung, HJ | 1 |
| Kwon, JY | 1 |
| Weon, JI | 1 |
| Koedrith, P | 1 |
| Park, KS | 1 |
| Kim, IS | 1 |
| Seo, YR | 1 |
| Yang, YX | 1 |
| Li, XL | 1 |
| Wang, L | 2 |
| Han, SY | 1 |
| Zhang, YR | 1 |
| Wang, X | 2 |
| Lu, J | 3 |
| Yin, YQ | 1 |
| Sun, LJ | 1 |
| Budhraja, A | 1 |
| Hitron, AJ | 1 |
| Ding, SZ | 1 |
| Zambelli, B | 1 |
| Ciurli, S | 1 |
| Fan, J | 1 |
| Hitron, JA | 1 |
| Wise, JT | 1 |
| Roy, RV | 1 |
| Kim, D | 1 |
| Dai, J | 1 |
| Huang, H | 2 |
| Zhu, J | 2 |
| Li, Y | 2 |
| Zhang, L | 1 |
| Gu, J | 1 |
| Xie, Q | 2 |
| Jin, H | 1 |
| Che, X | 1 |
| Li, J | 2 |
| Huang, C | 5 |
| Chen, LC | 3 |
| Lyu, J | 1 |
| Gao, J | 1 |
| Callegaro, G | 1 |
| Corvi, R | 1 |
| Salovaara, S | 1 |
| Urani, C | 1 |
| Stefanini, FM | 1 |
| Zhou, C | 1 |
| Wang, J | 1 |
| Liu, Y | 2 |
| Zhang, D | 1 |
| Zhu, Q | 1 |
| Pang, Y | 2 |
| Li, W | 2 |
| Ma, R | 1 |
| Ji, W | 3 |
| Wang, Q | 2 |
| Li, D | 1 |
| Xiao, Y | 2 |
| Wei, Q | 1 |
| Lai, Y | 1 |
| Yang, P | 1 |
| Chen, L | 1 |
| Tang, S | 1 |
| Lin, Y | 1 |
| Zhuang, Z | 3 |
| Zheng, Y | 1 |
| Chen, W | 2 |
| Kawata, K | 1 |
| Shimazaki, R | 1 |
| Okabe, S | 1 |
| Zhou, X | 1 |
| Li, Q | 1 |
| Arita, A | 1 |
| Yang, LQ | 1 |
| Ji, WD | 5 |
| Tao, GH | 1 |
| Zhang, WJ | 1 |
| Gong, CM | 1 |
| Zhou, L | 1 |
| Liu, JJ | 1 |
| Ke, YB | 1 |
| Zhuang, ZX | 1 |
| Pan, JJ | 1 |
| Chang, QS | 1 |
| Liu, J | 1 |
| Bi, YY | 1 |
| Clancy, HA | 1 |
| Passantino, L | 1 |
| Kluz, T | 3 |
| Muñoz, A | 1 |
| Zavadil, J | 1 |
| Yang, L | 3 |
| Zhang, M | 1 |
| Qi, D | 1 |
| Duan, X | 1 |
| Xuan, A | 1 |
| Zhang, W | 2 |
| Zeng, G | 1 |
| Miller, AC | 2 |
| Xu, J | 2 |
| Stewart, M | 2 |
| Brooks, K | 1 |
| Hodge, S | 1 |
| Shi, L | 1 |
| Page, N | 1 |
| McClain, D | 2 |
| Carrington, PE | 1 |
| Al-Mjeni, F | 1 |
| Zoroddu, MA | 2 |
| Maroney, MJ | 1 |
| Schinocca, L | 1 |
| Kowalik-Jankowska, T | 1 |
| Kozlowski, H | 1 |
| Salnikow, K | 13 |
| Kawanishi, S | 1 |
| Oikawa, S | 1 |
| Inoue, S | 1 |
| Nishino, K | 1 |
| Davidson, T | 3 |
| Oller, AR | 1 |
| Zhu, S | 1 |
| Wu, ZL | 4 |
| Chen, JK | 5 |
| Yi, F | 3 |
| Feng, SM | 3 |
| Kasprzak, KS | 6 |
| Bal, W | 1 |
| Karaczyn, AA | 2 |
| Chen, H | 1 |
| Zhou, D | 1 |
| Yan, Y | 1 |
| Zhao, D | 1 |
| Su, W | 1 |
| GILMAN, JP | 2 |
| HERCHEN, H | 2 |
| Su, WC | 1 |
| Sunderman, FW | 7 |
| Lü, JC | 3 |
| Jiang, YG | 1 |
| Shi, LY | 1 |
| He, M | 1 |
| Zeng, BH | 1 |
| Maxwell, P | 1 |
| Wu, YH | 1 |
| Zhang, ZY | 1 |
| Yang, BF | 1 |
| Kowara, R | 1 |
| Diwan, BA | 1 |
| Bare, RM | 1 |
| Waalkes, MP | 1 |
| Chiu, A | 1 |
| Katz, AJ | 1 |
| Beaubier, J | 1 |
| Chiu, N | 1 |
| Verma, R | 2 |
| Ramnath, J | 2 |
| Clemens, F | 2 |
| Kaspin, LC | 1 |
| Landolph, JR | 4 |
| Lu, H | 1 |
| Lei, YX | 1 |
| Chen, XM | 1 |
| Wu, GR | 1 |
| Golebiowski, F | 1 |
| Yu, L | 1 |
| Hu, D | 1 |
| Yang, J | 1 |
| Fu, J | 1 |
| Chen, J | 1 |
| Lin, Z | 1 |
| Rogers, RR | 1 |
| Garner, RJ | 1 |
| Riddle, MM | 1 |
| Luebke, RW | 1 |
| Smialowicz, RJ | 1 |
| Rivedal, E | 4 |
| Sanner, T | 4 |
| Hemstad, J | 1 |
| Reif, AE | 1 |
| Colton, T | 1 |
| Lechner, JF | 2 |
| Tokiwa, T | 1 |
| McClendon, IA | 1 |
| Haugen, A | 2 |
| Saxholm, HJ | 2 |
| Reith, A | 2 |
| Brøgger, A | 2 |
| Longstaff, E | 1 |
| Walker, AI | 1 |
| Jäckh, R | 1 |
| Geppert, H | 1 |
| Dominok, B | 1 |
| Hansen, K | 2 |
| Stern, RM | 3 |
| Heck, JD | 2 |
| Robison, SH | 1 |
| Simmons-Hansen, J | 2 |
| Bedrossian, CW | 1 |
| Bonura, J | 1 |
| Caprioli, RM | 1 |
| Abbracchio, MP | 1 |
| Mollenhauer, HH | 1 |
| Lin, X | 2 |
| Cosentino, S | 2 |
| Klein, C | 1 |
| Rani, AS | 1 |
| Qu, DQ | 1 |
| Sidhu, MK | 1 |
| Panagakos, F | 1 |
| Shah, V | 1 |
| Klein, KM | 1 |
| Brown, N | 1 |
| Pathak, S | 1 |
| Kumar, S | 1 |
| Qin, R | 1 |
| Peng, S | 1 |
| Jiang, X | 1 |
| Dowjat, WK | 1 |
| Huang, X | 1 |
| Kerckaert, GA | 1 |
| LeBoeuf, RA | 1 |
| Isfort, RJ | 1 |
| Shiao, YH | 1 |
| An, WG | 1 |
| Melillo, G | 1 |
| Blagosklonny, MV | 1 |
| Mao, X | 2 |
| Kashii, T | 2 |
| Hayashi, R | 1 |
| Sassa, K | 1 |
| Fujishita, T | 1 |
| Maruyama, M | 1 |
| Kobayashi, M | 1 |
| Liu, S | 2 |
| Tong, J | 1 |
| Denkhaus, E | 1 |
| Damjanov, I | 1 |
| Mitchell, JM | 1 |
| Allpass, PR | 2 |
| Lauwerys, R | 1 |
| DiPaolo, JA | 1 |
| Casto, BC | 1 |
| Nye, JS | 1 |
| Gondos, B | 1 |
| Hupp, T | 1 |
| Buhr, H | 1 |
| Ivancovic, S | 1 |
| Beck, N | 1 |
| Wang, XW | 3 |
| Klein, CB | 2 |
| Bhamra, RK | 2 |
| Lee, YW | 1 |
| Higashida, H | 1 |
| Hoshi, N | 1 |
| Hashii, M | 1 |
| Fu, T | 1 |
| Noda, M | 1 |
| Nozawa, Y | 1 |
| Conway, K | 4 |
| Lin, XH | 1 |
| Cohen, MD | 1 |
| Annab, L | 1 |
| Barrett, JC | 1 |
| Harris, CC | 1 |
| Yoakum, GH | 1 |
| Amstad, P | 1 |
| Korba, BE | 1 |
| Gabrielson, E | 1 |
| Grafstrom, R | 1 |
| Shamsuddin, A | 1 |
| Trump, BF | 1 |
| Swierenga, SH | 1 |
| Marceau, N | 1 |
| Katsuma, Y | 1 |
| French, SW | 1 |
| Mueller, R | 1 |
| Lee, F | 1 |
| Miura, T | 1 |
| Patierno, SR | 2 |
| Sakuramoto, T | 1 |
| Little, JB | 1 |
| Frenial, JM | 1 |
| Coppey, J | 1 |
| Tveito, G | 1 |
| Hansteen, IL | 1 |
| Dalen, H | 1 |
| Tang, P | 1 |
| Xu, G | 1 |
| Chen, XH | 1 |
| Wang, YP | 1 |
| Zhang, WG | 1 |
| Yuan, SL | 1 |
| Xu, LS | 1 |
| Sky-Peck, HH | 1 |
| Biedermann, KA | 1 |
| Hopfer, SM | 1 |
| Knight, JA | 1 |
| McCully, KS | 1 |
| Cecutti, AG | 1 |
| Thornhill, PG | 1 |
| Miller, C | 1 |
| Inbar, M | 2 |
| Sachs, L | 2 |
| Cline, MJ | 1 |
| Livingston, DC | 1 |
| Ben-Bassat, H | 1 |
| Barbarese, E | 1 |
| Sauerwein, H | 1 |
| Simpkins, H | 1 |
| Huet, C | 3 |
| Bernhard, W | 1 |
| Lonchampt, M | 1 |
| Huet, M | 1 |
| Bernadac, A | 2 |
| Daniel, M | 1 |
| Edwards, M | 1 |
| Webb, M | 1 |
20 reviews available for nickel and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
A comprehensive review of metal-induced cellular transformation studies.
Topics: Animals; Apoptosis; Arsenic; Carcinogens; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferati | 2017 |
Nickel and human health.
Topics: Cell Transformation, Neoplastic; Humans; Hypersensitivity; Intestinal Mucosa; Intestines; Nickel | 2013 |
Use of XAS for the elucidation of metal structure and function: applications to nickel biochemistry, molecular toxicology, and carcinogenesis.
Topics: Absorptiometry, Photon; Cell Transformation, Neoplastic; Cysteine; Histones; Humans; Ligands; Nickel | 2002 |
Molecular mechanisms in nickel carcinogenesis: modeling Ni(II) binding site in histone H4.
Topics: Amino Acid Sequence; Binding Sites; Cell Transformation, Neoplastic; Copper; Histones; Humans; Model | 2002 |
Respiratory carcinogenicity assessment of soluble nickel compounds.
Topics: Animals; Biological Availability; Cell Culture Techniques; Cell Transformation, Neoplastic; Disease | 2002 |
The role of chromatin damage in nickel-induced carcinogenesis. A review of recent developments.
Topics: Cell Transformation, Neoplastic; Chromatin; DNA Adducts; DNA Damage; Histones; Humans; Nickel; Prota | 2003 |
Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling.
Topics: Calcium Signaling; Cell Transformation, Neoplastic; Chromatin; Disease Progression; DNA Damage; DNA | 2003 |
Nickel carcinogenesis.
Topics: Air Pollutants; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA Damage; | 2003 |
HIF-1: an oxygen and metal responsive transcription factor.
Topics: Animals; Carcinogens; Cell Hypoxia; Cell Transformation, Neoplastic; Cobalt; DNA-Binding Proteins; E | 2004 |
Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings.
Topics: Animals; Carcinogens, Environmental; Cell Transformation, Neoplastic; Chromium; Drosophila; Electron | 2004 |
Ascorbate depletion: a critical step in nickel carcinogenesis?
Topics: Animals; Antioxidants; Ascorbic Acid; Cell Transformation, Neoplastic; DNA Damage; Homeostasis; Huma | 2005 |
Carcinogenic effect of nickel compounds.
Topics: Animals; Carcinogens, Environmental; Cell Transformation, Neoplastic; DNA Damage; Epigenesis, Geneti | 2005 |
Effects of nickel compounds in cell culture.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Cric | 1984 |
Carcinogenicity and mutagenicity of nickel and nickel compounds.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Coca | 1984 |
Nickel oxide: potential carcinogenicity--a review and further evidence.
Topics: Animals; Biological Availability; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Hum | 1984 |
Nickel essentiality, toxicity, and carcinogenicity.
Topics: Animals; Body Fluids; Calcium; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; D | 2002 |
[Occupational chemical pollution and cancer].
Topics: Acrylonitrile; Animals; Arsenic; Asbestosis; Belgium; Benzene Derivatives; Biotransformation; Cadmiu | 1979 |
Perspectives on the mechanism of nickel carcinogenesis gained from models of in vitro carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Heterochromatin; In Vitro Techniques; Ni | 1989 |
Trace metals and neoplasia.
Topics: Animals; Arsenic; Beryllium; Cadmium; Carcinogens; Cell Transformation, Neoplastic; Chromium; Chromo | 1986 |
Recent progress in nickel carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Cell-Free System; Chromosome Aberrations; Humans; Mutageni | 1986 |
96 other studies available for nickel and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; DNA Damage; DNA Repair; Humans; Hypoxia-Inducib | 2021 |
Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1α for Lung Tumorigenesis.
Topics: Angiopoietin-Like Protein 4; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, | 2020 |
RUNX2/miR‑31/SATB2 pathway in nickel‑induced BEAS‑2B cell transformation.
Topics: Bronchial Neoplasms; Cell Adhesion; Cell Line; Cell Movement; Cell Proliferation; Cell Transformatio | 2021 |
Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells.
Topics: Apoptosis; Autophagy; bcl-X Protein; Catalase; Cell Line, Transformed; Cell Transformation, Neoplast | 2017 |
Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells.
Topics: Arsenites; Cell Hypoxia; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Breaks, Double-Stran | 2017 |
Upregulation of microRNA-4417 and Its Target Genes Contribute to Nickel Chloride-promoted Lung Epithelial Cell Fibrogenesis and Tumorigenesis.
Topics: Cell Line, Transformed; Cell Transformation, Neoplastic; Epithelial Cells; Humans; Lung; Lung Neopla | 2017 |
The alteration of miR-222 and its target genes in nickel-induced tumor.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p27; Humans; | 2013 |
Passage-dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Hypoxia; Cell Proliferation; Cell Transformat | 2013 |
Identification of molecular candidates and interaction networks via integrative toxicogenomic analysis in a human cell line following low-dose exposure to the carcinogenic metals cadmium and nickel.
Topics: Biomarkers, Tumor; Cadmium; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Compara | 2013 |
Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells.
Topics: Apoptosis; bcl-X Protein; Catalase; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expressi | 2013 |
Cancer Stem-Like Cells Accumulated in Nickel-Induced Malignant Transformation.
Topics: Animals; Biomarkers, Tumor; Bronchi; Cell Differentiation; Cell Line; Cell Self Renewal; Cell Transf | 2016 |
Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Bronchi; Cell Line, Tumo | 2016 |
Relationship between increasing concentrations of two carcinogens and statistical image descriptors of foci morphology in the cell transformation assay.
Topics: Animals; BALB 3T3 Cells; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Transformation, Ne | 2017 |
LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1α translation.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Bronchi; Carcinogens; Carcinoma, Squamous Cell; Cell Line; C | 2017 |
Development of human cell models for assessing the carcinogenic potential of chemicals.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Benzo(a)pyrene; Bronchi; | 2008 |
Comparison of gene expression profiles in HepG2 cells exposed to arsenic, cadmium, nickel, and three model carcinogens for investigating the mechanisms of metal carcinogenesis.
Topics: Arsenic; Base Sequence; Cadmium; Carcinogens; Cell Line; Cell Transformation, Neoplastic; DNA Primer | 2009 |
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation.
Topics: Arsenites; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromates; Dose-Response Relationship, | 2009 |
[Genome DNA hypomethylation in the process of crystalline nickel-induced cell malignant transformation].
Topics: Bronchi; Cell Line; Cell Transformation, Neoplastic; DNA Methylation; Epithelial Cells; Genome; Huma | 2010 |
Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells.
Topics: Carcinogens; Cell Line, Transformed; Cell Transformation, Neoplastic; Down-Regulation; Enzyme Activa | 2011 |
Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer.
Topics: Arsenic; Bronchi; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromium; Epithelial Cell | 2012 |
MicroRNA-152 targets DNA methyltransferase 1 in NiS-transformed cells via a feedback mechanism.
Topics: 3' Untranslated Regions; Apoptosis; Blotting, Western; Bronchi; Carcinogens; Cell Proliferation; Cel | 2013 |
Observation of radiation-specific damage in human cells exposed to depleted uranium: dicentric frequency and neoplastic transformation as endpoints.
Topics: Cell Transformation, Neoplastic; Cells, Cultured; DNA Damage; Dose-Response Relationship, Radiation; | 2002 |
Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Damage; HeLa Cells; Humans; Hydrogen Pero | 2002 |
The role of hypoxia-inducible signaling pathway in nickel carcinogenesis.
Topics: Animals; Cell Cycle Proteins; Cell Hypoxia; Cell Transformation, Neoplastic; Disease Progression; DN | 2002 |
[Protection of beta-carotene and vitamin C on the transformation of human lung fibroblasts cell induced by nickel sesquioxide].
Topics: Antioxidants; Ascorbic Acid; beta Carotene; Cell Transformation, Neoplastic; Cells, Cultured; Fibrob | 2000 |
[Alteration of FHIT gene and p16 gene in malignant transformed cells induced by crystalline nickel sulfide].
Topics: Acid Anhydride Hydrolases; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Gene Exp | 2003 |
GeneChip analysis of signaling pathways effected by nickel.
Topics: Animals; Cell Culture Techniques; Cell Transformation, Neoplastic; Embryo, Mammalian; Fibroblasts; G | 2003 |
The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis.
Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; DNA-Binding Proteins; Gene Express | 2003 |
THE EFFECT OF PHYSICAL FORM OF IMPLANT ON NICKEL SULPHIDE TUMOURIGENESIS IN THE RAT.
Topics: Cell Transformation, Neoplastic; Neoplasm Metastasis; Nickel; Pathology; Rats; Research; Rhabdomyosa | 1963 |
EFFECT OF DURATION OF EXPOSURE ON NICKEL SULPHIDE TUMORIGENESIS.
Topics: Carcinogens; Cell Transformation, Neoplastic; Neoplasms; Neoplasms, Experimental; Nickel; Pathology; | 1964 |
Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A.
Topics: Animals; Anticarcinogenic Agents; Cell Line, Tumor; Cell Transformation, Neoplastic; Dose-Response R | 2003 |
[Study on lung carcinogenesis associated genes in human lung squamous cell carcinoma and malignant transformation of human bronchial epithelial cells induced by carcinogen].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bronchi; Carcinoma, Squamous Cell; Cell Transfor | 2003 |
[Morphological transformation of mouse NIH3T3 cells induced by nickel refining dusts in vitro].
Topics: Animals; Cell Transformation, Neoplastic; Dust; Mice; Nickel; NIH 3T3 Cells | 2003 |
Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas.
Topics: Acid Anhydride Hydrolases; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Mice; M | 2004 |
Molecular biology of nickel carcinogenesis: identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds.
Topics: Animals; Carcinogens; Cell Line, Transformed; Cell Transformation, Neoplastic; Embryo, Mammalian; Fi | 2004 |
Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines.
Topics: Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cell Line; Cell Line, Transformed; C | 2005 |
[Identification of protein peroxiredoxin 2 related to crystalline NiS-induced neoplastic transformation].
Topics: Bronchi; Cell Line; Cell Transformation, Neoplastic; Epithelial Cells; Humans; Nickel; Peroxiredoxin | 2005 |
Abnormal expression of eukaryotic translation factors in malignant transformed human bronchial epithelial cells induced by crystalline nickel sulfide.
Topics: Biomarkers; Bronchi; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA, | 2006 |
Ni(II) affects ubiquitination of core histones H2B and H2A.
Topics: Cell Line; Cell Transformation, Neoplastic; Histones; Humans; Lung; Methylation; Nickel; Ubiquitin; | 2006 |
Alterations of FHIT gene and P16 gene in nickel transformed human bronchial epithelial cells.
Topics: Acid Anhydride Hydrolases; Animals; Base Sequence; Bronchi; Cell Line; Cell Transformation, Neoplast | 2006 |
Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells.
Topics: Blotting, Western; Carcinogens; Cell Line; Cell Transformation, Neoplastic; DNA (Cytosine-5-)-Methyl | 2008 |
Augmentation of murine natural killer cell activity by manganese chloride.
Topics: Animals; Cell Transformation, Neoplastic; Chlorides; Female; Interferons; Killer Cells, Natural; Mal | 1983 |
Metal salts as promoters of in vitro morphological transformation of hamster embryo cells initiated by benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cadmium; Carcinogens; Cell Line; Cell Transformation, Neoplas | 1981 |
Synergistic effects of cigarette smoke extracts, benz (a) pyrene and nickel sulphate on morphological transformation of hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinoge | 1980 |
Determination of carcinogenic synergism from the latent period.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Drug Synergism; | 1984 |
Effects of nickel sulfate on growth and differentiation of normal human bronchial epithelial cells.
Topics: Bronchi; Cell Division; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Epidermal | 1984 |
[Dynamics of nickel in the cell].
Topics: Animals; Arsenicals; Cell Transformation, Neoplastic; Humans; Mitosis; Nickel | 1984 |
Toxicity and transformation potency of nickel compounds in BHK cells in vitro.
Topics: Acetates; Acetic Acid; Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cricetinae; | 1984 |
In vitro toxicity and transformation potency of nickel compounds.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Kidney; Nickel; Organometallic Comp | 1983 |
Organ and species specificity in nickel subsulfide carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Drug Evaluation, | 1983 |
Surface reduction of amorphous NiS particles potentiates their phagocytosis and subsequent induction of morphological transformation in Syrian hamster embryo cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Crystallization; Female; Mesocricet | 1982 |
Selective phagocytosis of crystalline metal sulfide particles and DNA strand breaks as a mechanism for the induction of cellular transformation.
Topics: Animals; Cadmium; Cadmium Compounds; Cell Transformation, Neoplastic; Cells, Cultured; Cobalt; Crice | 1982 |
Evaluation of tumour promoters by the hamster embryo cell transformation assay.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Cricetinae | 1982 |
Synergistic effect on morphological transformation of hamster embryo cells by nickel sulphate and benz[a]pyrene.
Topics: Animals; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Drug Synergism; | 1980 |
Phagocytosis, cellular distribution, and carcinogenic activity of particulate nickel compounds in tissue culture.
Topics: Animals; Cell Fractionation; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Cricetulus; Emb | 1981 |
Factors influencing the phagocytosis, neoplastic transformation, and cytotoxicity of particulate nickel compounds in tissue culture systems.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cell Transformation, Neoplastic; Cricetinae; Cricetul | 1981 |
Oncogenic transformation and cell lysis in C3H/10T 1/2 cells and increased sister chromatid exchange in human lymphocytes by nickel subsulfide.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Crossing Over, Genetic; Lymp | 1981 |
Phagocytosis of nickel subsulfide particles during the early stages of neoplastic transformation in tissue culture.
Topics: Animals; Benzopyrenes; Biological Transport; Cell Transformation, Neoplastic; Cells, Cultured; Cocar | 1980 |
Transformation of human osteoblasts to anchorage-independent growth by insoluble nickel particles.
Topics: Carcinogens; Cell Division; Cell Line; Cell Transformation, Neoplastic; Drug Evaluation, Preclinical | 1994 |
Loss of thrombospondin transcriptional activity in nickel-transformed cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Cloni | 1994 |
Transformation of immortal, non-tumorigenic osteoblast-like human osteosarcoma cells to the tumorigenic phenotype by nickel sulfate.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromosome Bandin | 1993 |
[Morphological transformation of BHK-21 cells by nickel titanium shape memory alloy particles encapsulated by titanium oxide].
Topics: Alloys; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Kidney; | 1995 |
Peroxidase deficiency of nickel-transformed hamster cells correlates with their increased resistance to cytotoxicity of peroxides.
Topics: Animals; Benzene Derivatives; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cloni | 1996 |
pH effects on the lifespan and transformation frequency of Syrian hamster embryo (SHE) cells.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cells, Culture | 1996 |
Cell cycle arrest, apoptosis and p53 expression in nickel(II) acetate-treated Chinese hamster ovary cells.
Topics: Acetates; Animals; Apoptosis; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; CHO Cells; C | 1998 |
Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors.
Topics: 3T3 Cells; Adenocarcinoma; Animals; Bone Neoplasms; Breast Neoplasms; Bronchi; Cadmium Chloride; Car | 1999 |
Cloning of differentially expressed sequence tags from nickel-transformed human embryonic lung cells.
Topics: Base Sequence; Blotting, Northern; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Transformation, N | 2000 |
Suppression of depleted uranium-induced neoplastic transformation of human cells by the phenyl fatty acid, phenyl acetate: chemoprevention by targeting the p21RAS protein pathway.
Topics: Animals; Anticarcinogenic Agents; Bone Neoplasms; Cell Transformation, Neoplastic; Female; Humans; M | 2001 |
[Studies on cell transformation and cell cycle in human embryo lungs induced by nickel compounds].
Topics: Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Humans; Lung; Nickel | 2000 |
Induction of testicular sarcomas in Fischer rats by intratesticular injection of nickel subsulfide.
Topics: Animals; Atrophy; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Fibrosarcoma; H | 1978 |
Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts.
Topics: Animals; Arsenic; Beryllium; Cadmium; Cell Transformation, Neoplastic; Cells, Cultured; Chromium; Cr | 1979 |
Induction of sarcomas in nude mice by implantation of Syrian hamster fetal cells exposed in vitro to nickel subsulfide.
Topics: Animals; Cell Transformation, Neoplastic; Clone Cells; Cricetinae; Dose-Response Relationship, Drug; | 1979 |
[Animal experiment studies of carcinogen-induced tumor development in colotomies in relation to suture materials].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplas | 1992 |
A conserved region in human and Chinese hamster X chromosomes can induce cellular senescence of nickel-transformed Chinese hamster cell lines.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cellular Senescence; Cricetinae; Cricetulus; Hu | 1992 |
Ba2+ current oscillation evoked by bradykinin in ras-transformed fibroblasts.
Topics: Animals; Barium; Bradykinin; Calcium; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Genes | 1991 |
Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control.
Topics: Animals; Cell Fusion; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Chromo | 1991 |
In vitro studies of human lung carcinogenesis.
Topics: Animals; Asbestos; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Chorionic | 1985 |
Altered cytokeratin expression and differentiation induction during neoplastic transformation of cultured rat liver cells by nickel subsulfide.
Topics: Animals; Antibodies, Monoclonal; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultu | 1989 |
Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds.
Topics: Animals; Carcinogenicity Tests; Cell Transformation, Neoplastic; Cells, Cultured; Female; Fibroblast | 1989 |
Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells.
Topics: Animals; Carcinogens; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrati | 1989 |
Studies of mutagenesis and neoplastic transformation by bivalent metal ions and ionizing radiation.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Magnesium; Mice; Mutation; Nickel; Time F | 1988 |
Immortalization of normal human kidney epithelial cells by nickel(II).
Topics: Carcinogens, Environmental; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations | 1989 |
[Studies of the effect of nickel and nickel compounds on transformation on Syrian hamster embryo cells].
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Embryo, Mammalian; Mesocricet | 1988 |
Effect of magnesium on nickel-induced genotoxicity and cell transformation.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Cricetinae; Crice | 1987 |
Indicators of matrix dependent variation in effective dose for chromium and nickel aerosol exposures.
Topics: Aerosols; Air Pollutants, Occupational; Animals; Cell Line, Transformed; Cell Transformation, Neopla | 1988 |
Induction of anchorage independence in human diploid foreskin fibroblasts by carcinogenic metal salts.
Topics: Acetates; Acetic Acid; Arsenates; Calcium Chloride; Carcinogens; Cell Adhesion; Cell Line; Cell Tran | 1987 |
Carcinogenicity and mutagenicity of some metals and their compounds.
Topics: Animals; Arsenic; Cadmium; Carcinogens; Cell Transformation, Neoplastic; Chromium; Chromosome Aberra | 1986 |
Physicochemical characteristics and biological effects of nickel oxides.
Topics: Animals; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chemical Phenomena; Chemis | 1987 |
Structural difference in sites on the surface membrane of normal and transformed cells.
Topics: Animals; Binding Sites; Cell Transformation, Neoplastic; Cricetinae; Membranes; Metals; Neoplasms, E | 1969 |
Binding of 3 H-concanavalin A by normal and transformed cells.
Topics: Adenoviridae; Agglutination; Animals; Cell Line; Cell Transformation, Neoplastic; Concanavalin A; Cr | 1971 |
Membrane changes associated with malignancy.
Topics: Agglutination; Animals; Binding Sites; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Co | 1972 |
Alterations in the surface glycoproteins of chicken erythrocytes following transformation with erythroblastosis strain R virus.
Topics: Animals; Avian Leukosis Virus; Binding Sites; Bone Marrow; Cell Aggregation; Cell Membrane; Cell Tra | 1973 |
Differences in the surface mobility between normal and SV40-, polyoma- and adenovirus-transformed hamster cells.
Topics: Adenoviridae; Agglutinins; Aldehydes; Animals; Cell Line; Cell Membrane Permeability; Cell Transform | 1974 |
Temperature effects on the concanavalin A molecule and on concanavalin A binding.
Topics: Agglutination Tests; Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Cell Tr | 1974 |
The effect of mental-serum complexes on differentiating muscle in vitro.
Topics: Animals; Blood Proteins; Cadmium; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chi | 1974 |
Peroxidase binding to cell-bound concanavalin A.
Topics: Animals; Binding Sites, Antibody; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Concana | 1974 |