Page last updated: 2024-10-19

nickel and Atopic Hypersensitivity

nickel has been researched along with Atopic Hypersensitivity in 43 studies

Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
nickel ion : A nickel atom having a net electric charge.
nickel atom : Chemical element (nickel group element atom) with atomic number 28.

Research Excerpts

ExcerptRelevanceReference
"Nickel sensitization is a growing problem and the most common cause of allergic contact dermatitis."7.76Nickel-induced allergy and contact dermatitis: does it induce autoimmunity and cutaneous sclerosis? An experimental study in Brown Norway rats. ( Adam, M; Al-Arfaj, AS; Al-Hammad, A; Al-Mogairen, SM; Al-Mohimed, B; El Rab, MO; Hamdani, M; Husain, S; Meo, SA, 2010)
"The prevalence of nickel allergy (sensitization) and the associations with ear piercing, use of dental braces and hand eczema were assessed in a cohort of 1,501 8th grade schoolchildren (aged 12-16 years) in Odense, Denmark."7.71Nickel sensitization in adolescents and association with ear piercing, use of dental braces and hand eczema. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). ( Andersen, KE; Bindslev-Jensen, C; Lauritsen, JM; Mortz, CG, 2002)
" Patients with allergy to nickel were provoked with nickel sulfate epicutaneously, and the reactions were evaluated by a clinical scoring system (guidelines of the International Contact Dermatitis Research Group)."5.09Dual effects of CGRP-antagonist on allergic contact dermatitis in human skin. ( Wallengren, J, 2000)
"Nickel sensitization is a growing problem and the most common cause of allergic contact dermatitis."3.76Nickel-induced allergy and contact dermatitis: does it induce autoimmunity and cutaneous sclerosis? An experimental study in Brown Norway rats. ( Adam, M; Al-Arfaj, AS; Al-Hammad, A; Al-Mogairen, SM; Al-Mohimed, B; El Rab, MO; Hamdani, M; Husain, S; Meo, SA, 2010)
"The prevalence of nickel allergy (sensitization) and the associations with ear piercing, use of dental braces and hand eczema were assessed in a cohort of 1,501 8th grade schoolchildren (aged 12-16 years) in Odense, Denmark."3.71Nickel sensitization in adolescents and association with ear piercing, use of dental braces and hand eczema. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). ( Andersen, KE; Bindslev-Jensen, C; Lauritsen, JM; Mortz, CG, 2002)
" Twelve other patients with IgE-mediated allergy were treated by CFS on the lower arm for 1 h and were then pricked with histamine and allergen extracts (wheal volume was measured) and were tested using benzoic acid (nonimmunologic contact urticaria; closed test)."3.71Cutaneous field stimulation of sensory nerve fibers reduces itch without affecting contact dermatitis. ( Wallengren, J, 2002)
"In a group of 612 consecutive patients undergoing routine patch tests for suspected allergic contact dermatitis, more than four-fifths of the 364 women had had their ears pierced, over half gave a history of cutaneous reactions to metallic jewelery and almost one-third were sensitive to nickel."3.68Nickel sensitivity: the influence of ear piercing and atopy. ( Cork, MJ; Gawkrodger, DJ; McDonagh, AJ; Wright, AL, 1992)
"Nickel-caused contact dermatitis is Type IV delayed hypersensitivity reaction occurring at least 24 h after exposure."3.01Delayed Severe Gingivitis After Placement of Orthodontic Braces in an Atopic Teenager: A Case Report and Literature Review. ( Godat, MS; Hammond, CM; Lew, DB; Stewart, CW, 2023)
"Ethylene oxide allergy was not identified in any of the participants."1.43Prevalence of delayed-type and immediate-type hypersensitivity in healthcare workers with hand eczema. ( Agner, T; Garvey, LH; Ibler, KS; Jemec, GB, 2016)
"This study suggests the presence of Type I hypersensitivity in addition to a Type IV immune reaction in patients with chronic systemic symptoms related to nickel."1.42Oral nickel exposure may induce Type I hypersensitivity reaction in nickel-sensitized subjects. ( Büyüköztürk, S; Çelik, DD; Çolakoğlu, B; Demirtürk, M; Erdem Kuruca, S; Erden, S; Gelincik, A; Ünal, D, 2015)
"We report a case of type 1 and type IV contact hypersensitivity to nickel."1.36Type 1 and type IV hypersensitivity to nickel. ( King, CM; Smith, VH; Walsh, ML, 2010)
"Allergic contact dermatitis is one of the most frequent dermatological problems affecting 7% of the general population."1.35Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. ( Baurecht, H; Behrendt, H; Heinrich, J; Illig, T; Klopp, N; Novak, N; Ring, J; Rodriguez, E; Schäfer, T; Wagenpfeil, S; Weidinger, S; Wichmann, E, 2008)
"Our results suggest the reaction was a type I hypersensitivity reaction to ethylenediamine, but a nonimmune mechanism could not be excluded."1.29Immediate adverse reaction to aminophylline. ( Cuevas, M; de la Hoz, B; Lázaro, M; Pérez, C; Salazar, F; Tejedor, MA, 1993)
"The lifetime occurrence of atopic eczema was 20% in boys (12% in the past year) and 19% in girls (11% in the past year)."1.29The prevalence of childhood atopic eczema in a general population. ( Gawkrodger, DJ; Jaron, AG; Kay, J; Mortimer, MJ, 1994)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199011 (25.58)18.7374
1990's11 (25.58)18.2507
2000's15 (34.88)29.6817
2010's5 (11.63)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Stewart, CW1
Hammond, CM1
Godat, MS1
Lew, DB1
Watts, TJ1
Watts, S1
Thursfield, D1
Haque, R1
Büyüköztürk, S1
Gelincik, A1
Ünal, D1
Demirtürk, M1
Çelik, DD1
Erden, S1
Çolakoğlu, B1
Erdem Kuruca, S1
Ibler, KS1
Jemec, GB1
Garvey, LH1
Agner, T1
de Mello, LM1
Bechara, MI1
Solé, D1
Rodrigues, V1
Al-Mogairen, SM1
Meo, SA1
Al-Arfaj, AS1
Hamdani, M1
Husain, S1
Al-Mohimed, B1
Adam, M1
Al-Hammad, A1
El Rab, MO1
Walsh, ML1
Smith, VH1
King, CM1
Mortz, CG1
Lauritsen, JM1
Bindslev-Jensen, C1
Andersen, KE1
Wallengren, J2
Silvennoinen-Kassinen, S1
Ilonen, J1
Tiilikainen, A1
Karvonen, J1
Marigo, M1
Nouer, DF1
Genelhu, MC1
Malaquias, LC1
Pizziolo, VR1
Costa, AS1
Martins-Filho, OA1
Alves-Oliveira, LF1
GARCIAPEREZ, A1
PEREZPEREZ, B1
GUTIERREZ, CM1
van Kampen, V1
Merget, R1
Brüning, T1
Moed, H1
von Blomberg, M1
Bruynzeel, DP2
Scheper, R1
Gibbs, S1
Rustemeyer, T1
Brasch, J1
Schnuch, A1
Uter, W1
Szarmach, IJ1
Kasacka, I1
Buczko, P1
Tankiewicz, A1
Pawlak, D1
Khan, SF1
Sherbondy, MA1
Ormsby, A1
Velanovich, V1
Vitályos, G1
Török, J1
Márton, I1
Szepesi, M1
Radics, T1
Hegedus, C1
Novak, N1
Baurecht, H1
Schäfer, T1
Rodriguez, E1
Wagenpfeil, S1
Klopp, N1
Heinrich, J1
Behrendt, H1
Ring, J1
Wichmann, E1
Illig, T1
Weidinger, S1
Hanifin, JM1
McGrath, KG1
Zeiss, CR1
Patterson, R1
Mitchell, JC1
de la Hoz, B1
Pérez, C1
Tejedor, MA1
Lázaro, M1
Salazar, F1
Cuevas, M1
Oranje, AP1
Stenveld, HJ1
Dieges, PH1
Vilaplana, J2
Romaguera, C2
Cornellana, F1
Kay, J1
Gawkrodger, DJ2
Mortimer, MJ1
Jaron, AG1
Nordlind, K1
Liden, S1
Memon, AA1
Friedmann, PS1
de la Cruz Lopez, M1
Máiz, J1
Vidal, C1
Penide, L1
Werfel, T1
Boeker, M1
Kapp, A1
de Vries, IJ1
Langeveld-Wildschut, EG1
van Reijsen, FC1
Bihari, IC1
Bruijnzeel-Koomen, CA1
Thepen, T1
Boscolo, P1
Di Gioacchino, M1
Sabbioni, E1
Di Giacomo, F1
Reale, M1
Volpe, AR1
Di Sciascio, MB1
Conti, P1
Giuliano, G1
Walsh, G1
Mitchell, JW1
Lyell, A1
Bain, WH1
Thomson, RM1
McDonagh, AJ1
Wright, AL1
Cork, MJ1
Norbäck, D1
Edling, C1
Grimalt, F1
Ramón Soler, R1
Gallart Castany, J1
Rodamilans Pérez, MI1
To Figueras, J1
Todd, DJ1
Burrows, D1
Stanford, CF1
Tosti, A1
Melino, M1
Labanca, M1
Ragazzi, R1
Gottmann-Lückerath, I1
Ehring, G1
Steigleder, GK1
Watt, TL1
Baumann, RR1

Reviews

3 reviews available for nickel and Atopic Hypersensitivity

ArticleYear
Delayed Severe Gingivitis After Placement of Orthodontic Braces in an Atopic Teenager: A Case Report and Literature Review.
    Pediatric allergy, immunology, and pulmonology, 2023, Volume: 36, Issue:2

    Topics: Adolescent; Cobalt; Dermatitis, Contact; Gingivitis; Humans; Hypersensitivity, Delayed; Hypersensiti

2023
[Immediate type allergies due to metal - nickel].
    Pneumologie (Stuttgart, Germany), 2003, Volume: 57, Issue:11

    Topics: Adult; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Immediate; Male; Metals; Middle Aged

2003
Allergic reactions to industrial chemicals.
    Clinical immunology reviews, 1983, Volume: 2, Issue:1

    Topics: Adult; Animals; Asthma; Chemical Industry; Cyanates; Dermatitis, Atopic; Dogs; Ethylenediamines; Gui

1983

Trials

1 trial available for nickel and Atopic Hypersensitivity

ArticleYear
Dual effects of CGRP-antagonist on allergic contact dermatitis in human skin.
    Contact dermatitis, 2000, Volume: 43, Issue:3

    Topics: Adult; Aged; Calcitonin Gene-Related Peptide; Dermatitis, Allergic Contact; Dermatitis, Contact; Der

2000

Other Studies

39 other studies available for nickel and Atopic Hypersensitivity

ArticleYear
A Patch Testing Initiative for the Investigation of Allergic Contact Dermatitis in a UK Allergy Practice: A Retrospective Study.
    The journal of allergy and clinical immunology. In practice, 2019, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Aged; Allergens; Dermatitis, Allergic Contact; Female; Humans; Hypersensitivity,

2019
Oral nickel exposure may induce Type I hypersensitivity reaction in nickel-sensitized subjects.
    International immunopharmacology, 2015, Volume: 26, Issue:1

    Topics: Case-Control Studies; Cell Proliferation; Cells, Cultured; Cytokines; Dental Alloys; Female; Humans;

2015
Prevalence of delayed-type and immediate-type hypersensitivity in healthcare workers with hand eczema.
    Contact dermatitis, 2016, Volume: 75, Issue:4

    Topics: Adult; Aged; Allergens; Chlorhexidine; Denmark; Dermatitis, Allergic Contact; Dermatitis, Occupation

2016
TH1/TH2 balance in concomitant immediate and delayed-type hypersensitivity diseases.
    Immunology letters, 2009, Jun-04, Volume: 124, Issue:2

    Topics: Adult; Allergens; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Cells, Cultured; Cysteine

2009
Nickel-induced allergy and contact dermatitis: does it induce autoimmunity and cutaneous sclerosis? An experimental study in Brown Norway rats.
    Rheumatology international, 2010, Volume: 30, Issue:9

    Topics: Administration, Cutaneous; Animals; Antibodies, Antinuclear; Autoantibodies; Autoimmunity; Dermatiti

2010
Type 1 and type IV hypersensitivity to nickel.
    The Australasian journal of dermatology, 2010, Volume: 51, Issue:4

    Topics: Adult; Dermatitis, Contact; Female; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate;

2010
Nickel sensitization in adolescents and association with ear piercing, use of dental braces and hand eczema. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS).
    Acta dermato-venereologica, 2002, Volume: 82, Issue:5

    Topics: Adolescent; Child; Cohort Studies; Confidence Intervals; Cross-Sectional Studies; Dental Alloys; Der

2002
Cutaneous field stimulation of sensory nerve fibers reduces itch without affecting contact dermatitis.
    Allergy, 2002, Volume: 57, Issue:12

    Topics: Administration, Cutaneous; Adult; Aged; Anti-Infective Agents, Local; Antifungal Agents; Benzalkoniu

2002
No significant association between HLA and nickel contact sensitivity.
    Tissue antigens, 1979, Volume: 14, Issue:5

    Topics: Adolescent; Adult; Dermatitis, Allergic Contact; Female; Finland; Gene Frequency; Genetic Predisposi

1979
Evaluation of immunologic profile in patients with nickel sensitivity due to use of fixed orthodontic appliances.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2003, Volume: 124, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Antigen-Antibody Reactions; Antigens; Blood; Cells, Culture

2003
[POSITIVE REACTION TO THE SKIN TEST FOR CHROMIUM AND NICKEL IN OBVIOUSLY NON-CONTACT CLINICAL ECZEMAS].
    Actas dermo-sifiliograficas, 1963, Volume: 54

    Topics: Chromium; Dermatitis; Dermatitis, Atopic; Dermatitis, Contact; Eczema; Humans; Hypersensitivity, Imm

1963
Improved detection of allergen-specific T-cell responses in allergic contact dermatitis through the addition of 'cytokine cocktails'.
    Experimental dermatology, 2005, Volume: 14, Issue:8

    Topics: Adult; Allergens; Cell Proliferation; Coloring Agents; Cytokines; Dermatitis, Allergic Contact; Fema

2005
Strong allergic patch test reactions may indicate a general disposition for contact allergy.
    Allergy, 2006, Volume: 61, Issue:3

    Topics: Adolescent; Adult; Age Distribution; Allergens; Dermatitis, Allergic Contact; Disease Susceptibility

2006
Oral cavity status and IgE level in orthodontic patients.
    Advances in medical sciences, 2006, Volume: 51 Suppl 1

    Topics: Adolescent; Adult; Child; Female; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Mouth

2006
Occlusion of metallic biliary stent related to nickel allergy.
    Gastrointestinal endoscopy, 2007, Volume: 66, Issue:2

    Topics: Alloys; Cholestasis; Constriction, Pathologic; Female; Humans; Hypersensitivity, Immediate; Middle A

2007
[Orthodontic treatment possibilities of allergic patients].
    Fogorvosi szemle, 2007, Volume: 100, Issue:2

    Topics: Adolescent; Alloys; Dental Materials; Dermatitis, Contact; Female; Humans; Hypersensitivity, Immedia

2007
Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:6

    Topics: Adult; Animals; Dermatitis, Allergic Contact; Female; Filaggrin Proteins; Humans; Hypersensitivity;

2008
Filaggrin mutations and allergic contact sensitization.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:6

    Topics: Animals; Dermatitis, Allergic Contact; Dermatitis, Atopic; Eczema; Filaggrin Proteins; Humans; Hyper

2008
Type I without type III and type IV hypersensitivity reaction to nickel.
    Contact dermatitis, 1981, Volume: 7, Issue:5

    Topics: Dermatitis, Contact; Humans; Hypersensitivity, Immediate; Male; Middle Aged; Nickel; Occupational Di

1981
Immediate adverse reaction to aminophylline.
    Annals of allergy, 1993, Volume: 71, Issue:5

    Topics: Administration, Oral; Aged; Aminophylline; Dermatitis, Allergic Contact; Drug Hypersensitivity; Ethy

1993
Immediate- and delayed-type contact hypersensitivity in children older than 5 years with atopic dermatitis: a pilot study comparing different tests.
    Pediatric dermatology, 1994, Volume: 11, Issue:3

    Topics: Adolescent; Allergens; Balsams; Child; Child, Preschool; Cobalt; Dermatitis, Atopic; Dermatitis, Con

1994
Contact dermatitis and adverse oral mucous membrane reactions related to the use of dental prostheses.
    Contact dermatitis, 1994, Volume: 30, Issue:2

    Topics: Burning Mouth Syndrome; Cobalt; Dental Materials; Dental Prosthesis; Dermatitis, Contact; Dermatitis

1994
The prevalence of childhood atopic eczema in a general population.
    Journal of the American Academy of Dermatology, 1994, Volume: 30, Issue:1

    Topics: Asthma; Breast Feeding; Child; Child, Preschool; Dermatitis, Atopic; Ear, External; Female; Humans;

1994
In vitro lymphocyte reactivity to heavy metal salts in the diagnosis of oral mucosal hypersensitivity to amalgam restorations.
    The British journal of dermatology, 1993, Volume: 128, Issue:1

    Topics: Chlorides; Dental Amalgam; DNA; Drug Hypersensitivity; Humans; Hypersensitivity, Immediate; Interfer

1993
'Angry back syndrome': a non-reproducible phenomenon.
    The British journal of dermatology, 1996, Volume: 135, Issue:6

    Topics: Back; Humans; Hypersensitivity, Immediate; Nickel; Patch Tests; Reproducibility of Results; Skin; Sy

1996
Unusual complication in liposuction due to metals hypersensitivity.
    Plastic and reconstructive surgery, 1997, Volume: 99, Issue:5

    Topics: Adult; Dermatitis, Contact; Equipment Design; Female; Humans; Hypersensitivity, Immediate; Intraoper

1997
Rapid expression of the CD69 antigen on T cells and natural killer cells upon antigenic stimulation of peripheral blood mononuclear cell suspensions.
    Allergy, 1997, Volume: 52, Issue:4

    Topics: Adult; Allergens; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Binding Sites, Ant

1997
Nonspecific T-cell homing during inflammation in atopic dermatitis: expression of cutaneous lymphocyte-associated antigen and integrin alphaE beta7 on skin-infiltrating T cells.
    The Journal of allergy and clinical immunology, 1997, Volume: 100, Issue:5

    Topics: Antigens, Differentiation, T-Lymphocyte; Antigens, Neoplasm; Biomarkers, Tumor; CD3 Complex; Dermati

1997
Lymphocyte subpopulations, cytokines and trace elements in asymptomatic atopic women exposed to an urban environment.
    Life sciences, 2000, Volume: 67, Issue:10

    Topics: Adult; Chromium; Cities; Copper; Environmental Exposure; Female; Humans; Hypersensitivity, Immediate

2000
Free surface nickel in CE-marked and non-CE-marked spectacle frames.
    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2002, Volume: 22, Issue:2

    Topics: Dermatitis, Contact; Eyeglasses; Humans; Hypersensitivity, Immediate; Nickel; Titanium

2002
Metal sensitivity.
    Lancet (London, England), 1976, Mar-27, Volume: 1, Issue:7961

    Topics: Arthroplasty; Chromium Alloys; Humans; Hypersensitivity, Immediate; Joint Prosthesis; Nickel

1976
Repeated failure of nickel-containing prosthetic heart valves in a patient allergic to nickel.
    Lancet (London, England), 1978, Sep-23, Volume: 2, Issue:8091

    Topics: Female; Follow-Up Studies; Heart Valve Prosthesis; Humans; Hypersensitivity, Immediate; Middle Aged;

1978
Nickel sensitivity: the influence of ear piercing and atopy.
    The British journal of dermatology, 1992, Volume: 126, Issue:1

    Topics: Adult; Age Factors; Dermatitis, Contact; Ear, External; Female; Hand Dermatoses; Humans; Hypersensit

1992
Environmental, occupational, and personal factors related to the prevalence of sick building syndrome in the general population.
    British journal of industrial medicine, 1991, Volume: 48, Issue:7

    Topics: Adult; Aged; Computer Terminals; Drug Hypersensitivity; Electricity; Environmental Exposure; Epidemi

1991
[Nickel, chromium and cobalt release from a metal prosthesis in metal-sensitive patients].
    Medicina cutanea ibero-latino-americana, 1989, Volume: 17, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chromium; Cobalt; Female; Hip Prosthesis; Humans; Hypers

1989
Atopy in subjects with a history of nickel allergy but negative patch tests.
    Contact dermatitis, 1989, Volume: 21, Issue:3

    Topics: Dermatitis, Atopic; Female; Humans; Hypersensitivity, Immediate; Nickel; Respiratory Function Tests;

1989
Immediate hypersensitivity to nickel.
    Contact dermatitis, 1986, Volume: 15, Issue:2

    Topics: Adult; Dermatitis, Contact; Female; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate;

1986
[Comparative studies of the epi- and intradermal skin test with the metal salts of chromium, cobalt, copper, and nickel].
    Archiv fur dermatologische Forschung, 1973, Mar-19, Volume: 246, Issue:2

    Topics: Adolescent; Adult; Aged; Chromium; Cobalt; Copper; Dermatitis, Occupational; Drug Hypersensitivity;

1973
Nickel earlobe dermatitis.
    Archives of dermatology, 1968, Volume: 98, Issue:2

    Topics: Adolescent; Adult; Cosmetics; Dermatitis, Atopic; Female; Humans; Hypersensitivity, Immediate; Nicke

1968