nicardipine has been researched along with Vasospasm, Intracranial in 65 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study evaluated the effect of diltiazem, a calcium antagonist, on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage (SAH) during the hyperacute stage." | 9.20 | Effects of diltiazem on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage. ( Kurita, H; Nakajima, H; Ogura, T; Ooigawa, H; Takeda, R, 2015) |
| "Intraventricular nicardipine was associated with a significant and sustained reduction in mean cerebral blood flow velocity as measured by transcranial Doppler when used in the treatment of suspected cerebral vasospasm following aneurysmal subarachnoid hemorrhage." | 9.14 | The effect of intraventricular administration of nicardipine on mean cerebral blood flow velocity measured by transcranial Doppler in the treatment of vasospasm following aneurysmal subarachnoid hemorrhage. ( Kolenda, J; Martin, K; Samuels, O; Webb, A; Wright, W, 2010) |
| "Our aim was to determine the effects of intra-arterial (IA) nicardipine infusion on the cerebral hemodynamics of patients with aneurysmal subarachnoid hemorrhage (aSAH)-induced vasospasm by using first-pass quantitative cine CT perfusion (CTP)." | 9.14 | Intra-arterial nicardipine infusion improves CT perfusion-measured cerebral blood flow in patients with subarachnoid hemorrhage-induced vasospasm. ( Gonzalez, RG; Halpern, EF; Hirsch, JA; Lev, MH; Nogueira, RG; Ogilvy, CS; Pryor, JC; Rabinov, JD; Roccatagliata, L; Rordorf, GA, 2009) |
| "The purpose of this study was to investigate the effect of nicardipine prolonged-release implants (NPRIs) on cerebral vasospasm and clinical outcome after severe subarachnoid hemorrhage." | 9.12 | Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study. ( Barth, M; Capelle, HH; Kasuya, H; Luecke, T; Münch, E; Schmiedek, P; Thomé, C; Vajkoczy, P; Weidauer, S; Weiss, C, 2007) |
| "Intrathecal nicardipine has been shown to have some efficacy for the treatment of symptomatic cerebral vasospasm in aneurysmal subarachnoid hemorrhage (aSAH)." | 9.01 | Systematic Review of Intrathecal Nicardipine for the Treatment of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage. ( Grandhi, R; Hafeez, S, 2019) |
| " Using a propensity-score model, this patient cohort was compared to patients in the Subarachnoid Hemorrhage International Trialists (SAHIT) repository who did not receive IT nicardipine." | 8.12 | Does intrathecal nicardipine for cerebral vasospasm following subarachnoid hemorrhage correlate with reduced delayed cerebral ischemia? A retrospective propensity score-based analysis. ( Akbik, F; Ameli, P; Asbury, W; Barrow, DL; Cawley, CM; Danyluk, L; Feng, C; Garner, K; Jaja, BNR; Kolenda, J; Kraft, J; Macdonald, RL; Martin, KS; Mathew, S; Mei, Y; Moore, R; Pearce, D; Pimentel, C; Pujari, A; Sadan, O; Samuels, O; Taylor, A; Waddel, H, 2022) |
| "To develop a nicardipine prolonged-release implant (NPRI) to prevent cerebral vasospasm in patients with subarachnoid hemorrhage in 1999, which may be used during craniotomy, and report the results of our recent 12-year single critical care center experience." | 7.96 | Twelve-year single critical care center experience of nicardipine prolonged-release implants in patients with subarachnoid hemorrhage: a propensity score matching analysis. ( Arai, N; Funaki, A; Hagiwara, S; Itoh, T; Kasuya, H; Kuroi, Y; Ohbuchi, H; Sasahara, A; Sato, Y; Takahashi, Y, 2020) |
| "Nimodipine improved outcome in patients with subarachnoid hemorrhage (SAH) although hypotension limited the dose that could be administered systemically." | 7.78 | Cisternal sustained release dihydropyridines for subarachnoid hemorrhage. ( Ai, J; Cook, DJ; Kan, S; Kasuya, H; Macdonald, RL, 2012) |
| "Intra-arterial (IA) nicardipine is often used to treat cerebral vasospasm associated with subarachnoid hemorrhage (SAH)." | 7.77 | High-dose intra-arterial nicardipine results in hypotension following vasospasm treatment in subarachnoid hemorrhage. ( Lazzaro, MA; Lopes, DK; Prabhakaran, S; Rosenberg, N, 2011) |
| "Adenosine cardiac arrest is a relatively novel method for decompression of intracranial aneurysms to facilitate clip application." | 7.77 | Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. ( Borel, CO; Britz, GW; Guinn, NR; Lam, AM; McDonagh, DL; Powers, CJ; Warner, DS; Wright, DR; Zomorodi, AR, 2011) |
| "IT nicardipine was administered to six patients with aneurysmal subarachnoid hemorrhage after prophylactic and aggressive therapeutic management for vasospasm failed." | 7.75 | Use of intrathecal nicardipine for aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm. ( Bayless, L; Ehtisham, A; Janzen, JM; Klein, MW; Samuels, OB; Taylor, S, 2009) |
| "Administration of intra-arterial magnesium sulfate in combination with nicardipine was well tolerated in patients with subarachnoid hemorrhage and cerebral vasospasm without a significant change in MAP and ICP." | 7.75 | Super-selective intra-arterial magnesium sulfate in combination with nicardipine for the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage. ( Georgiadis, AL; Kozak, OS; Memon, MZ; Qureshi, AI; Rodriguez, GJ; Shah, QA; Suri, MF; Taylor, RA; Tummala, RP; Vazquez, G, 2009) |
| "To evaluate the prophylactic effect of repeated intrathecal administration of nicardipine associated with hypertensive hypervolemic hemodilution therapy (triple H) and sodium correction, we analyzed a consecutive series of 177 patients with subarachnoid hemorrhage." | 7.71 | Intrathecal administration of nicardipine hydrochloride to prevent vasospasm in patients with subarachnoid hemorrhage. ( Doi, M; Ogasawara, K; Ogawa, A; Otawara, Y; Suzuki, M, 2001) |
| "We studied the feasibility of intrathecal nicardipine administration using a portable infusion pump system in five cases (two males and three females) of subarachnoid hemorrhage (SAH)." | 7.71 | [Continuous intrathecal administration of nicardipine using a portable infusion pump system for management of vasospasm after subarachnoid hemorrhage]. ( Ebina, T; Fujiwara, K; Mikawa, S, 2001) |
| "Nicardipine has long been recognized as a potent cerebrovascular vasodilator with a history off-label use to prevent vasospasm and DCI." | 6.72 | Nicardipine Prolonged Release Implants for Prevention of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis. ( Akbik, F; Jaja, BNR; Macdonald, RL; Moore, R; Sadan, O; Samuels, OB; Waddel, H, 2021) |
| "Cerebral vasospasm after non-traumatic subarachnoid hemorrhage is a major concern; cerebral vasospasm refers to the narrowing of the cerebral vessels, which can lead to stroke." | 6.58 | Effectiveness of intrathecal nicardipine on cerebral vasospasm in non-traumatic subarachnoid hemorrhage: a systematic review. ( Christian, R; Palokas, M; Stuart, D; Uschmann, H, 2018) |
| "The subjects were 158 patients with aneurysmal subarachnoid hemorrhage." | 5.46 | Preventing Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage with Aggressive Cisternal Clot Removal and Nicardipine. ( Hashimoto, A; Kamada, K; Kamiyama, H; Kinoshita, Y; Matsukawa, H; Miyazaki, T; Noda, K; Ota, N; Saito, N; Tanikawa, R; Tokuda, S; Tsuboi, T, 2017) |
| "Symptomatic cerebral vasospasm (SCV) is the second most common of morbidity and mortality in aneurysmal subarachnoid hemorrhage (aSAH) after rebleeding." | 5.42 | Effects of Clot Removal by Meticulous Irrigation and Continuous Low-Dose Intravenous Nicardipine on Symptomatic Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage Treated by Clipping. ( Kamiyama, H; Matsukawa, H; Miyata, S; Noda, K; Ota, N; Suzuki, G; Takeda, R; Tanikawa, R; Tokuda, S; Tsuboi, T, 2015) |
| "In this small series, high-dose intra-arterial nicardipine infusion to treat SAH-associated vasospasm seems to be safe and effective." | 5.34 | Safety and feasibility of intra-arterial nicardipine for the treatment of subarachnoid hemorrhage-associated vasospasm: initial clinical experience with high-dose infusions. ( Chaloupka, JC; Hayakawa, M; Lee, SK; Taylor, RA; Tejada, JG; Ugurel, MS, 2007) |
| "Vasospasm following subarachnoid hemorrhage (SAH) remains difficult to prevent despite extensive investigative efforts." | 5.34 | Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients. ( Hori, T; Kasuya, H; Krischek, B; Onda, H, 2007) |
| " Clazosentan, nicardipine, fasudil, and magnesium showed beneficial effects on delayed cerebral ischemia and vasospasm but they were not found to reduce mortality or disability." | 5.22 | Prophylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials. ( Ahmadvand, S; Amin-Hanjani, S; Dayyani, M; Grotta, JC; Guyatt, GH; Sadeghirad, B; Wang, Y; Zabihyan, S, 2022) |
| "One of the challenges in bringing new therapeutic agents (since nimodipine) in for the treatment of cerebral ischemia associated with aneurysmal subarachnoid hemorrhage (aSAH) is the incongruence in therapeutic benefit observed between phase II and subsequent phase III clinical trials." | 5.22 | Lessons Learned from Phase II and Phase III Trials Investigating Therapeutic Agents for Cerebral Ischemia Associated with Aneurysmal Subarachnoid Hemorrhage. ( Broderick, JP; Cassarly, CN; Huang, W; Ishfaq, MF; Lobanova, I; Macdonald, RL; Martin, RH; Qureshi, AI; Suarez, JI, 2022) |
| "This study evaluated the effect of diltiazem, a calcium antagonist, on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage (SAH) during the hyperacute stage." | 5.20 | Effects of diltiazem on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage. ( Kurita, H; Nakajima, H; Ogura, T; Ooigawa, H; Takeda, R, 2015) |
| "since October 1999, nicardipine pellets (NP) have been used to prevent vasospasm in patients with subarachnoid hemorrhage (SAH)." | 5.15 | Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo. ( Kasuya, H, 2011) |
| "Intraventricular nicardipine was associated with a significant and sustained reduction in mean cerebral blood flow velocity as measured by transcranial Doppler when used in the treatment of suspected cerebral vasospasm following aneurysmal subarachnoid hemorrhage." | 5.14 | The effect of intraventricular administration of nicardipine on mean cerebral blood flow velocity measured by transcranial Doppler in the treatment of vasospasm following aneurysmal subarachnoid hemorrhage. ( Kolenda, J; Martin, K; Samuels, O; Webb, A; Wright, W, 2010) |
| "Our aim was to determine the effects of intra-arterial (IA) nicardipine infusion on the cerebral hemodynamics of patients with aneurysmal subarachnoid hemorrhage (aSAH)-induced vasospasm by using first-pass quantitative cine CT perfusion (CTP)." | 5.14 | Intra-arterial nicardipine infusion improves CT perfusion-measured cerebral blood flow in patients with subarachnoid hemorrhage-induced vasospasm. ( Gonzalez, RG; Halpern, EF; Hirsch, JA; Lev, MH; Nogueira, RG; Ogilvy, CS; Pryor, JC; Rabinov, JD; Roccatagliata, L; Rordorf, GA, 2009) |
| "The purpose of this study was to investigate the effect of nicardipine prolonged-release implants (NPRIs) on cerebral vasospasm and clinical outcome after severe subarachnoid hemorrhage." | 5.12 | Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study. ( Barth, M; Capelle, HH; Kasuya, H; Luecke, T; Münch, E; Schmiedek, P; Thomé, C; Vajkoczy, P; Weidauer, S; Weiss, C, 2007) |
| "Twenty consecutive subarachnoid hemorrhage patients with thick subarachnoid clot were treated with NPRI (a pellet of diameter 2 mm, length 10 mm, containing 4 mg of nicardipine) during surgery after clipping of their aneurysm." | 5.10 | Efficacy and safety of nicardipine prolonged-release implants for preventing vasospasm in humans. ( Hori, T; Kasuya, H; Okada, Y; Onda, H; Takeshita, M, 2002) |
| "Intrathecal nicardipine has been shown to have some efficacy for the treatment of symptomatic cerebral vasospasm in aneurysmal subarachnoid hemorrhage (aSAH)." | 5.01 | Systematic Review of Intrathecal Nicardipine for the Treatment of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage. ( Grandhi, R; Hafeez, S, 2019) |
| " Using a propensity-score model, this patient cohort was compared to patients in the Subarachnoid Hemorrhage International Trialists (SAHIT) repository who did not receive IT nicardipine." | 4.12 | Does intrathecal nicardipine for cerebral vasospasm following subarachnoid hemorrhage correlate with reduced delayed cerebral ischemia? A retrospective propensity score-based analysis. ( Akbik, F; Ameli, P; Asbury, W; Barrow, DL; Cawley, CM; Danyluk, L; Feng, C; Garner, K; Jaja, BNR; Kolenda, J; Kraft, J; Macdonald, RL; Martin, KS; Mathew, S; Mei, Y; Moore, R; Pearce, D; Pimentel, C; Pujari, A; Sadan, O; Samuels, O; Taylor, A; Waddel, H, 2022) |
| "In New Zealand white rabbits (N = 22), vasospasm was individually provoked through experimentally induced subarachnoid hemorrhage and confirmed via conventional angiography, grouping animals by IA-infused drug (nicardipine vs." | 4.12 | Comparative Study of Vasodilatation After Intra-arterial Nicardipine or Dantrolene Infusion in Animal Model of Cerebral Vasospasm. ( Byoun, HS; Cho, YD; Lim, J, 2022) |
| "To develop a nicardipine prolonged-release implant (NPRI) to prevent cerebral vasospasm in patients with subarachnoid hemorrhage in 1999, which may be used during craniotomy, and report the results of our recent 12-year single critical care center experience." | 3.96 | Twelve-year single critical care center experience of nicardipine prolonged-release implants in patients with subarachnoid hemorrhage: a propensity score matching analysis. ( Arai, N; Funaki, A; Hagiwara, S; Itoh, T; Kasuya, H; Kuroi, Y; Ohbuchi, H; Sasahara, A; Sato, Y; Takahashi, Y, 2020) |
| "Nimodipine improved outcome in patients with subarachnoid hemorrhage (SAH) although hypotension limited the dose that could be administered systemically." | 3.78 | Cisternal sustained release dihydropyridines for subarachnoid hemorrhage. ( Ai, J; Cook, DJ; Kan, S; Kasuya, H; Macdonald, RL, 2012) |
| "Adenosine cardiac arrest is a relatively novel method for decompression of intracranial aneurysms to facilitate clip application." | 3.77 | Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. ( Borel, CO; Britz, GW; Guinn, NR; Lam, AM; McDonagh, DL; Powers, CJ; Warner, DS; Wright, DR; Zomorodi, AR, 2011) |
| "Intra-arterial (IA) nicardipine is often used to treat cerebral vasospasm associated with subarachnoid hemorrhage (SAH)." | 3.77 | High-dose intra-arterial nicardipine results in hypotension following vasospasm treatment in subarachnoid hemorrhage. ( Lazzaro, MA; Lopes, DK; Prabhakaran, S; Rosenberg, N, 2011) |
| "We conducted a single-center, retrospective review of consecutive patients with clinically symptomatic vasospasm after aneurysmal subarachnoid hemorrhage that failed medical management with "triple H therapy" and subsequently received intraarterial nicardipine and/or milrinone between March 2005 and July 2007." | 3.76 | Hemodynamic management and outcome of patients treated for cerebral vasospasm with intraarterial nicardipine and/or milrinone. ( Bittner, E; Marota, JJ; Pivi, S; Schmidt, U, 2010) |
| "Administration of intra-arterial magnesium sulfate in combination with nicardipine was well tolerated in patients with subarachnoid hemorrhage and cerebral vasospasm without a significant change in MAP and ICP." | 3.75 | Super-selective intra-arterial magnesium sulfate in combination with nicardipine for the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage. ( Georgiadis, AL; Kozak, OS; Memon, MZ; Qureshi, AI; Rodriguez, GJ; Shah, QA; Suri, MF; Taylor, RA; Tummala, RP; Vazquez, G, 2009) |
| "IT nicardipine was administered to six patients with aneurysmal subarachnoid hemorrhage after prophylactic and aggressive therapeutic management for vasospasm failed." | 3.75 | Use of intrathecal nicardipine for aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm. ( Bayless, L; Ehtisham, A; Janzen, JM; Klein, MW; Samuels, OB; Taylor, S, 2009) |
| "We studied the feasibility of intrathecal nicardipine administration using a portable infusion pump system in five cases (two males and three females) of subarachnoid hemorrhage (SAH)." | 3.71 | [Continuous intrathecal administration of nicardipine using a portable infusion pump system for management of vasospasm after subarachnoid hemorrhage]. ( Ebina, T; Fujiwara, K; Mikawa, S, 2001) |
| "To evaluate the prophylactic effect of repeated intrathecal administration of nicardipine associated with hypertensive hypervolemic hemodilution therapy (triple H) and sodium correction, we analyzed a consecutive series of 177 patients with subarachnoid hemorrhage." | 3.71 | Intrathecal administration of nicardipine hydrochloride to prevent vasospasm in patients with subarachnoid hemorrhage. ( Doi, M; Ogasawara, K; Ogawa, A; Otawara, Y; Suzuki, M, 2001) |
| "Nicardipine has long been recognized as a potent cerebrovascular vasodilator with a history off-label use to prevent vasospasm and DCI." | 2.72 | Nicardipine Prolonged Release Implants for Prevention of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis. ( Akbik, F; Jaja, BNR; Macdonald, RL; Moore, R; Sadan, O; Samuels, OB; Waddel, H, 2021) |
| "Cilostazol was found to be the second-best treatment in improving favorable outcomes (OR, 3." | 2.72 | Effects of Various Therapeutic Agents on Vasospasm and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage-Results of a Network Meta-Analysis. ( Chandra, PS; Gaonkar, VB; Garg, K; Kale, SS; Mishra, S; Singh, M; Singh, PM; Suri, A, 2021) |
| "Cerebral vasospasm after non-traumatic subarachnoid hemorrhage is a major concern; cerebral vasospasm refers to the narrowing of the cerebral vessels, which can lead to stroke." | 2.58 | Effectiveness of intrathecal nicardipine on cerebral vasospasm in non-traumatic subarachnoid hemorrhage: a systematic review. ( Christian, R; Palokas, M; Stuart, D; Uschmann, H, 2018) |
| "Outcome of patients with aneurysmal subarachnoid hemorrhage (SAH) has improved over the last decades." | 2.49 | SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials. ( Cusimano, MD; Etminan, N; Hanggi, D; Hasan, D; Ilodigwe, D; Jaja, B; Lantigua, H; Le Roux, P; Lo, B; Louffat-Olivares, A; Macdonald, RL; Mayer, S; Molyneux, A; Quinn, A; Schenk, T; Schweizer, TA; Singh, J; Spears, J; Todd, M; Torner, J; Vergouwen, MD; Wong, GK, 2013) |
| "We present a case of diffuse cerebral vasospasm, which improved with intra-arterial nicardipine." | 2.47 | Intra-arterial nicardipine for the treatment of cerebral vasospasm in postpartum cerebral angiopathy: a case study and review of literature. ( Husmann, K; Lele, A; Lyon, T; Pollack, A; Reeves, A, 2011) |
| "Cerebral vasospasm is still one of the leading causes of morbidity and mortality from subarachnoid hemorrhage." | 2.43 | Endovascular treatment of cerebral vasospasm: transluminal balloon angioplasty, intra-arterial papaverine, and intra-arterial nicardipine. ( Hoh, BL; Ogilvy, CS, 2005) |
| "Nicardipine is a calcium antagonist belonging to the dihydropyridine group of molecules." | 2.41 | [Intravenous nicardipine: a new calcium antagonist for perioperative use]. ( Barcina Sánchez, M; Muñoz Alameda, LE, 2001) |
| "Patients with cerebral vasospasm caused by aneurysmal subarachnoid hemorrhage (aSAH) are often treated with intra-arterial (IA) vasodilator infusion." | 1.62 | Use of single versus multiple vasodilator agents in the treatment of cerebral vasospasm: is more better than less? ( Bulsara, K; Chen, PR; Day, AL; Erkmen, K; Kim, DH; Lopez-Rivera, V; Oni-Orisan, AO; Sanzgiri, A; Sheriff, FG; Sheth, S; Vahidy, FS, 2021) |
| "The subjects were 158 patients with aneurysmal subarachnoid hemorrhage." | 1.46 | Preventing Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage with Aggressive Cisternal Clot Removal and Nicardipine. ( Hashimoto, A; Kamada, K; Kamiyama, H; Kinoshita, Y; Matsukawa, H; Miyazaki, T; Noda, K; Ota, N; Saito, N; Tanikawa, R; Tokuda, S; Tsuboi, T, 2017) |
| "Postoperative meningitis is a serious complication occurring after neurosurgical interventions." | 1.42 | Risk factors for meningitis after craniotomy in patients with subarachnoid hemorrhage due to anterior circulation aneurysms rupture. ( Endo, H; Fujimura, M; Inoue, T; Niizuma, K; Sakata, H; Sato, K; Shimizu, H; Tominaga, T, 2015) |
| "Symptomatic cerebral vasospasm (SCV) is the second most common of morbidity and mortality in aneurysmal subarachnoid hemorrhage (aSAH) after rebleeding." | 1.42 | Effects of Clot Removal by Meticulous Irrigation and Continuous Low-Dose Intravenous Nicardipine on Symptomatic Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage Treated by Clipping. ( Kamiyama, H; Matsukawa, H; Miyata, S; Noda, K; Ota, N; Suzuki, G; Takeda, R; Tanikawa, R; Tokuda, S; Tsuboi, T, 2015) |
| "We report a case of subarachnoid hemorrhage from a thrombosed ruptured aneurysm which was undetected on digital subtraction angiography but was visualized with cone beam volume CT." | 1.39 | The utility of cone beam volume CT in the evaluation of thrombosed intracranial aneurysms in subarachnoid hemorrhage. ( Hannawi, Y; Murthy, SB; Rao, CP; Shah, S, 2013) |
| "Nicardipine was infused at 20 mg/h for 30 to 60 minutes." | 1.38 | A simplified method for administration of intra-arterial nicardipine for vasospasm with cervical catheter infusion. ( Do, HM; Dodd, R; Marks, MP; Pandey, P; Steinberg, GK, 2012) |
| "Nicardipine (1 mg/mL/min) was infused intra-arterially by microcatheter." | 1.35 | Angiographic and hemodynamic effect of high concentration of intra-arterial nicardipine in cerebral vasospasm. ( Andreone, V; Delgado-Mederos, R; Gounis, M; Hendricks, L; Linfante, I; Wakhloo, AK, 2008) |
| "Severe cerebral vasospasm was found on MR angiography and confirmed on conventional cerebral angiography." | 1.35 | Successful treatment of severe cerebral vasospasm following hemorrhage of an arteriovenous malformation. Case report. ( Cornfield, D; Dodd, R; Edwards, MS; Guzman, R; Pendharkar, AV, 2009) |
| "Cerebral vasospasm after subarachnoid hemorrhage can decrease cerebral blood flow with the potential for stroke." | 1.34 | Anesthetic considerations of selective intra-arterial nicardipine injection for intracranial vasospasm: a case series. ( Avitsian, R; Fiorella, D; Mascha, E; Soliman, MM, 2007) |
| "The dose-response studies revealed that intracarotid administration of nicardipine, compared with verapamil, was more effective in augmenting cerebral blood flow." | 1.34 | Augmentation of cerebral blood flow and reversal of endothelin-1-induced vasospasm: a comparison of intracarotid nicardipine and verapamil. ( Etu, JJ; Joshi, S; Lavine, SD; Meyers, PM; Wang, M, 2007) |
| "In this small series, high-dose intra-arterial nicardipine infusion to treat SAH-associated vasospasm seems to be safe and effective." | 1.34 | Safety and feasibility of intra-arterial nicardipine for the treatment of subarachnoid hemorrhage-associated vasospasm: initial clinical experience with high-dose infusions. ( Chaloupka, JC; Hayakawa, M; Lee, SK; Taylor, RA; Tejada, JG; Ugurel, MS, 2007) |
| "Vasospasm following subarachnoid hemorrhage (SAH) remains difficult to prevent despite extensive investigative efforts." | 1.34 | Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients. ( Hori, T; Kasuya, H; Krischek, B; Onda, H, 2007) |
| " These results suggested that nicardipine-prolonged release preparation is safe as well as effective for cerebral vasospasm." | 1.31 | [The efficacy and safety of the nicardipine prolonged-release implant in a canine double hemorrhage model]. ( Aihara, Y; Hori, T; Izawa, M; Kasuya, H; Kawashima, A; Sasahara, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 26 (40.00) | 29.6817 |
| 2010's | 29 (44.62) | 24.3611 |
| 2020's | 10 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Qureshi, AI | 2 |
| Lobanova, I | 1 |
| Huang, W | 1 |
| Ishfaq, MF | 1 |
| Broderick, JP | 1 |
| Cassarly, CN | 1 |
| Martin, RH | 1 |
| Macdonald, RL | 6 |
| Suarez, JI | 1 |
| Lim, J | 1 |
| Cho, YD | 1 |
| Byoun, HS | 1 |
| Dayyani, M | 1 |
| Sadeghirad, B | 1 |
| Grotta, JC | 1 |
| Zabihyan, S | 1 |
| Ahmadvand, S | 1 |
| Wang, Y | 1 |
| Guyatt, GH | 1 |
| Amin-Hanjani, S | 1 |
| Carrera, DA | 1 |
| Marsh, LM | 1 |
| Roach, JJ | 1 |
| Sarangarm, P | 1 |
| Cole, CD | 1 |
| Torbey, MT | 1 |
| Carlson, AP | 1 |
| Kuroi, Y | 1 |
| Ohbuchi, H | 1 |
| Arai, N | 1 |
| Takahashi, Y | 1 |
| Hagiwara, S | 1 |
| Sasahara, A | 4 |
| Funaki, A | 1 |
| Itoh, T | 1 |
| Sato, Y | 1 |
| Kasuya, H | 14 |
| Chen, PR | 1 |
| Bulsara, K | 1 |
| Lopez-Rivera, V | 1 |
| Sheriff, FG | 1 |
| Sanzgiri, A | 1 |
| Sheth, S | 1 |
| Oni-Orisan, AO | 1 |
| Vahidy, FS | 1 |
| Erkmen, K | 1 |
| Kim, DH | 1 |
| Day, AL | 1 |
| Zeitouni, D | 1 |
| Parish, JM | 1 |
| Smith, M | 1 |
| Stetler, WR | 1 |
| Bernard, JD | 1 |
| Sadan, O | 2 |
| Waddel, H | 2 |
| Moore, R | 2 |
| Feng, C | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Intra-arterial Vasospasm Trial(iVAST)- A Multi-center Randomized Study[NCT01996436] | Phase 4 | 330 participants (Anticipated) | Interventional | 2016-08-29 | Recruiting | ||
| the Effect of Different Modes of Mechanical Ventilation on Cerebral Blood Flow During Thoracoscopic Surgeries in Neonates (RCT)[NCT04507295] | 30 participants (Anticipated) | Interventional | 2020-08-08 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for nicardipine and Vasospasm, Intracranial
| Article | Year |
|---|---|
Lessons Learned from Phase II and Phase III Trials Investigating Therapeutic Agents for Cerebral Ischemia Associated with Aneurysmal Subarachnoid Hemorrhage.
Topics: Brain Ischemia; Cerebral Infarction; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III | 2022 |
Prophylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials.
Topics: Adult; Brain Ischemia; Cilostazol; Humans; Magnesium; Morbidity; Network Meta-Analysis; Nicardipine; | 2022 |
Effects of Various Therapeutic Agents on Vasospasm and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage-Results of a Network Meta-Analysis.
Topics: Cilostazol; Delayed-Action Preparations; Humans; Network Meta-Analysis; Nicardipine; Randomized Cont | 2021 |
Nicardipine Prolonged Release Implants for Prevention of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis.
Topics: Brain Ischemia; Drug Implants; Humans; Incidence; Network Meta-Analysis; Nicardipine; Recovery of Fu | 2021 |
Effectiveness of intrathecal nicardipine on cerebral vasospasm in non-traumatic subarachnoid hemorrhage: a systematic review.
Topics: Adult; Blood Flow Velocity; Cross Infection; Female; Humans; Injections, Spinal; Intensive Care Unit | 2018 |
Systematic Review of Intrathecal Nicardipine for the Treatment of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Flow Velocity; Cerebrovascular Circulation; Humans; Injections, Intraventricular; Injections, | 2019 |
Intracranial Administration of Nicardipine After Aneurysmal Subarachnoid Hemorrhage: A Review of the Literature.
Topics: Drug Implants; Female; Humans; Injections; Male; Nicardipine; Subarachnoid Hemorrhage; Vasodilator A | 2019 |
SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials.
Topics: Antioxidants; Brain Infarction; Calcium Channel Blockers; Critical Care; Dioxanes; Drug Therapy, Com | 2013 |
Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angioplasty, Balloon; Critical Care; Endovascular Pro | 2010 |
Intra-arterial nicardipine for the treatment of cerebral vasospasm in postpartum cerebral angiopathy: a case study and review of literature.
Topics: Adult; Brain; Female; Humans; Injections, Intra-Arterial; Magnetic Resonance Angiography; Magnetic R | 2011 |
Therapeutic approaches to vasospasm in subarachnoid hemorrhage.
Topics: Angioplasty, Balloon; Blood Volume; Calcium Channel Blockers; Fibrinolytic Agents; Fluid Therapy; He | 2002 |
Endovascular treatment of cerebral vasospasm: transluminal balloon angioplasty, intra-arterial papaverine, and intra-arterial nicardipine.
Topics: Angioplasty, Balloon; Humans; Injections, Intra-Arterial; Nicardipine; Papaverine; Vasodilator Agent | 2005 |
Blood pressure management in patients with intracerebral and subarachnoid hemorrhage.
Topics: Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Blood Volume; Brain; Brain Ischemia; E | 2006 |
[Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Angioplasty, Balloon; Calcium Channel | 2008 |
[Intravenous nicardipine: a new calcium antagonist for perioperative use].
Topics: Adenosine Triphosphate; Calcium; Calcium Channel Blockers; Drug Interactions; Electrocardiography; H | 2001 |
9 trials available for nicardipine and Vasospasm, Intracranial
| Article | Year |
|---|---|
Effects of diltiazem on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage.
Topics: Acute Disease; Aged; Calcium Channel Blockers; Diltiazem; Female; Humans; Male; Middle Aged; Nicardi | 2015 |
Intra-arterial nicardipine infusion improves CT perfusion-measured cerebral blood flow in patients with subarachnoid hemorrhage-induced vasospasm.
Topics: Adult; Cerebrovascular Circulation; Contrast Media; Female; Humans; Infusions, Intra-Arterial; Male; | 2009 |
The effect of intraventricular administration of nicardipine on mean cerebral blood flow velocity measured by transcranial Doppler in the treatment of vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Calcium Channel Blockers; Cerebrovascular Circulation; Female; Humans; Injections, Intraventricular; | 2010 |
Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Calcium Channel Blockers; Cooperative Be | 2011 |
Feasibility of intraventricular nicardipine prolonged release implants in patients following aneurysmal subarachnoid haemorrhage.
Topics: Adult; Aged; Angiography, Digital Subtraction; Brain Infarction; Cerebral Ventricles; Delayed-Action | 2011 |
Development of nicardipine prolonged-release implants after clipping for preventing cerebral vasospasm: from laboratory to clinical trial.
Topics: Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Drug D | 2013 |
Preliminary experience with intra-arterial nicardipine as a treatment for cerebral vasospasm.
Topics: Adult; Aged; Calcium Channel Blockers; Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; | 2004 |
Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study.
Topics: Adult; Delayed-Action Preparations; Double-Blind Method; Drug Implants; Female; Humans; Intracranial | 2007 |
Efficacy and safety of nicardipine prolonged-release implants for preventing vasospasm in humans.
Topics: Aged; Anterior Cerebral Artery; Carotid Artery, Internal; Cerebral Angiography; Craniotomy; Delayed- | 2002 |
41 other studies available for nicardipine and Vasospasm, Intracranial
| Article | Year |
|---|---|
Comparative Study of Vasodilatation After Intra-arterial Nicardipine or Dantrolene Infusion in Animal Model of Cerebral Vasospasm.
Topics: Animals; Dantrolene; Models, Animal; Nicardipine; Rabbits; Subarachnoid Hemorrhage; Vasospasm, Intra | 2022 |
HummingFlow: novel single twist-drill access for ventricular drainage, irrigation, monitoring, and automated local drug delivery in subarachnoid hemorrhage.
Topics: Cerebral Hemorrhage; Drainage; Humans; Nicardipine; Subarachnoid Hemorrhage; Tissue Plasminogen Acti | 2023 |
Twelve-year single critical care center experience of nicardipine prolonged-release implants in patients with subarachnoid hemorrhage: a propensity score matching analysis.
Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Critical Care; Female; Humans; Male; Middle Age | 2020 |
Use of single versus multiple vasodilator agents in the treatment of cerebral vasospasm: is more better than less?
Topics: Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nicardipine; Nitroglycerin; Retrospect | 2021 |
Reversible cerebral vasoconstriction syndrome successfully treated by intrathecal nicardipine.
Topics: Adult; Female; Headache Disorders, Primary; Humans; Injections, Spinal; Nicardipine; Syndrome; Vasod | 2021 |
Does intrathecal nicardipine for cerebral vasospasm following subarachnoid hemorrhage correlate with reduced delayed cerebral ischemia? A retrospective propensity score-based analysis.
Topics: Adult; Age Factors; Aged; Aneurysm, Ruptured; Aortic Rupture; Calcium Channel Blockers; Critical Car | 2022 |
Preventing Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage with Aggressive Cisternal Clot Removal and Nicardipine.
Topics: Aged; Female; Humans; Intracranial Thrombosis; Male; Middle Aged; Nicardipine; Observer Variation; P | 2017 |
Endovascular management of cerebral vasospasm following aneurysm rupture: outcomes and predictors in 116 patients.
Topics: Adult; Aged; Angioplasty, Balloon; Calcium Channel Blockers; Cerebral Infarction; Combined Modality | 2014 |
A novel approach to diagnose reversible cerebral vasoconstriction syndrome: a case series.
Topics: Adult; Diagnosis, Differential; Female; Headache Disorders, Primary; Humans; Infusions, Intra-Arteri | 2015 |
Effects of Clot Removal by Meticulous Irrigation and Continuous Low-Dose Intravenous Nicardipine on Symptomatic Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage Treated by Clipping.
Topics: Adult; Aged; Female; Humans; Infusions, Intravenous; Logistic Models; Male; Middle Aged; Nicardipine | 2015 |
Risk factors for meningitis after craniotomy in patients with subarachnoid hemorrhage due to anterior circulation aneurysms rupture.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angiography, Digital Subtraction; Antibiotic Pro | 2015 |
Effectiveness of intrathecal nicardipine on cerebral vasospasm in non-traumatic subarachnoid hemorrhage: a systematic review protocol.
Topics: Antihypertensive Agents; Humans; Injections, Spinal; Nicardipine; Subarachnoid Hemorrhage; Systemati | 2017 |
Intra-arterial calcium channel blocker infusion for treatment of severe vasospasm in traumatic brain injury: case report.
Topics: Accidents, Traffic; Adult; Brain Injuries; Calcium Channel Blockers; Cerebral Angiography; Cerebral | 2008 |
Angiographic and hemodynamic effect of high concentration of intra-arterial nicardipine in cerebral vasospasm.
Topics: Angiography; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Cerebral Arteries; Femal | 2008 |
Use of intrathecal nicardipine for aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm.
Topics: Adult; Calcium Channel Blockers; Female; Humans; Injections, Spinal; Male; Middle Aged; Nicardipine; | 2009 |
Super-selective intra-arterial magnesium sulfate in combination with nicardipine for the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage.
Topics: Adult; Aged; Analgesics; Angioplasty; Blood Pressure; Cerebral Arteries; Female; Humans; Infusions, | 2009 |
Successful treatment of severe cerebral vasospasm following hemorrhage of an arteriovenous malformation. Case report.
Topics: Adolescent; Angioplasty, Balloon; Cerebral Hemorrhage; Humans; Intracranial Arteriovenous Malformati | 2009 |
Hemodynamic management and outcome of patients treated for cerebral vasospasm with intraarterial nicardipine and/or milrinone.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Drug Therapy, Combination; | 2010 |
Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review.
Topics: Adenosine; Aged; Anesthesia, General; Antihypertensive Agents; Cardiovascular Agents; Dose-Response | 2011 |
Nicardipine pellets for the prevention of cerebral vasospasm.
Topics: Angiography, Digital Subtraction; Calcium Channel Blockers; Delayed-Action Preparations; Humans; Lon | 2011 |
Refractory caffeine and ergot-induced cervico-cerebral vasospasm and stroke treated with combined medical and endovascular approach.
Topics: Adult; Caffeine; Cerebral Angiography; Dihydroergotamine; Drug Therapy, Combination; Female; Humans; | 2012 |
High-dose intra-arterial nicardipine results in hypotension following vasospasm treatment in subarachnoid hemorrhage.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cerebral Angiography; Circle of Willis; Dose-Respons | 2011 |
The use of nicardipine prolonged release implants (NPRI) in microsurgical clipping after aneurysmal subarachnoid haemorrhage: comparison with endovascular treatment.
Topics: Case-Control Studies; Delayed-Action Preparations; Drug Implants; Female; Humans; Male; Middle Aged; | 2011 |
A simplified method for administration of intra-arterial nicardipine for vasospasm with cervical catheter infusion.
Topics: Cerebral Angiography; Female; Humans; Infusions, Intra-Arterial; Male; Nicardipine; Vasodilator Agen | 2012 |
Cortical spreading ischemia in the absence of proximal vasospasm after aneurysmal subarachnoid hemorrhage: evidence for a dual mechanism of delayed cerebral ischemia.
Topics: Antihypertensive Agents; Brain Ischemia; Cortical Spreading Depression; Female; Humans; Male; Nicard | 2012 |
Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Angiography, Digital Subtraction; Antihypertensive Agents; Brain; Brain Ischemia; Corti | 2012 |
Intraventricular nicardipine for aneurysmal subarachnoid hemorrhage related vasospasm: assessment of 90 days outcome.
Topics: Adult; Calcium Channel Blockers; Case-Control Studies; Critical Care; Female; Follow-Up Studies; Hum | 2012 |
Cisternal sustained release dihydropyridines for subarachnoid hemorrhage.
Topics: Animals; Delayed-Action Preparations; Dihydropyridines; Disease Models, Animal; Dogs; Female; Macaca | 2012 |
The utility of cone beam volume CT in the evaluation of thrombosed intracranial aneurysms in subarachnoid hemorrhage.
Topics: Activities of Daily Living; Aneurysm, Ruptured; Angiography, Digital Subtraction; Angioplasty, Ballo | 2013 |
Anesthetic considerations of selective intra-arterial nicardipine injection for intracranial vasospasm: a case series.
Topics: Adult; Aged; Anesthesia; Blood Pressure; Calcium Channel Blockers; Female; Heart Rate; Humans; Injec | 2007 |
Augmentation of cerebral blood flow and reversal of endothelin-1-induced vasospasm: a comparison of intracarotid nicardipine and verapamil.
Topics: Animals; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelin-1; Injections, In | 2007 |
Safety and feasibility of intra-arterial nicardipine for the treatment of subarachnoid hemorrhage-associated vasospasm: initial clinical experience with high-dose infusions.
Topics: Adult; Aged; Cerebral Angiography; Feasibility Studies; Female; Humans; Infusions, Intra-Arterial; M | 2007 |
Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients.
Topics: Aged; Aneurysm, Ruptured; Drug Implants; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; M | 2007 |
[Endovascular treatment of vasospasm following subarachnoid aneurysmal haemorrhage].
Topics: Calcium Channel Blockers; Humans; Intracranial Aneurysm; Nicardipine; Nimodipine; Nitroprusside; Pap | 2007 |
Intraventricular nicardipine for refractory cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Brain; Brain Ischemia; Female; Humans; Injections, Intraventricular; Male; Middle Aged; | 2008 |
Late vasospasm is very difficult to control, since it is caused by strong chemical reaction to the smooth muscle.
Topics: Humans; Intracranial Aneurysm; Muscle, Smooth, Vascular; Nicardipine; Vasodilator Agents; Vasospasm, | 2008 |
Prevention of cerebral vasospasm by nicardipine prolonged-release implants in dogs.
Topics: Animals; Brain; Cerebral Angiography; Delayed-Action Preparations; Disease Models, Animal; Dogs; Dru | 2000 |
[The efficacy and safety of the nicardipine prolonged-release implant in a canine double hemorrhage model].
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Dogs; Drug Implants; Nicardipine; Safe | 2000 |
[Continuous intrathecal administration of nicardipine using a portable infusion pump system for management of vasospasm after subarachnoid hemorrhage].
Topics: Aged; Aged, 80 and over; Disposable Equipment; Female; Humans; Infusion Pumps, Implantable; Injectio | 2001 |
Development of nicardipine prolonged-release implants for preventing vasospasm.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Implants; In Vitro Techniques; Nicardipine; Su | 2001 |
Intrathecal administration of nicardipine hydrochloride to prevent vasospasm in patients with subarachnoid hemorrhage.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Cerebral Angiography; Female; H | 2001 |