nicardipine has been researched along with Spinal Cord Injuries in 3 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Then nicardipine 1 mg i." | 5.35 | [Case of autonomic hyperreflexia treated with intravenous nicardipine]. ( Hirota, K; Ishihara, H; Kimura, F; Saito, J, 2009) |
| "Autonomic dysreflexia is a hypertensive episode in spinal cord-injured individuals induced by exaggerated sympathetic activity and thought to be alpha-adrenergic mediated." | 2.75 | Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals. ( Danser, AH; Deinum, J; Geurts, AC; Groothuis, JT; Hopman, MT; Pickkers, P; Rongen, GA; Smits, P, 2010) |
| "Then nicardipine 1 mg i." | 1.35 | [Case of autonomic hyperreflexia treated with intravenous nicardipine]. ( Hirota, K; Ishihara, H; Kimura, F; Saito, J, 2009) |
| " We carried out preliminary behavioral toxicity testing to identify a range of low, moderate, and high dosage levels of the calcium channel blocker, nicardipine; these dosage levels were to be used subsequently in formal testing." | 1.27 | Experimental spinal cord injury: effect of a calcium channel antagonist (nicardipine). ( Black, P; Finkelstein, SD; Gillespie, JA; Markowitz, RS; McMonagle-Strucko, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saito, J | 1 |
| Kimura, F | 1 |
| Ishihara, H | 1 |
| Hirota, K | 1 |
| Groothuis, JT | 1 |
| Rongen, GA | 1 |
| Deinum, J | 1 |
| Pickkers, P | 1 |
| Danser, AH | 1 |
| Geurts, AC | 1 |
| Smits, P | 1 |
| Hopman, MT | 1 |
| Black, P | 1 |
| Markowitz, RS | 1 |
| Finkelstein, SD | 1 |
| McMonagle-Strucko, K | 1 |
| Gillespie, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Mecamylamine for Autonomic Dysreflexia Prophylaxis[NCT03914677] | Phase 4 | 5 participants (Anticipated) | Interventional | 2019-06-13 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for nicardipine and Spinal Cord Injuries
| Article | Year |
|---|---|
Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Angiotensin II; Autonomic Dysreflexia; Autonomic Nervous | 2010 |
2 other studies available for nicardipine and Spinal Cord Injuries
| Article | Year |
|---|---|
[Case of autonomic hyperreflexia treated with intravenous nicardipine].
Topics: Adult; Anesthesia, Intravenous; Autonomic Dysreflexia; Colostomy; Humans; Infusions, Intravenous; In | 2009 |
Experimental spinal cord injury: effect of a calcium channel antagonist (nicardipine).
Topics: Animals; Calcium Channel Blockers; Female; Hindlimb; Male; Motor Activity; Nicardipine; Rats; Rats, | 1988 |