nicardipine has been researched along with Pre-Eclampsia in 24 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After 30 inclusions, the study was stopped because of the high rate of persistent hypertension using ketanserin and the high rate of maternal side effects using dihydralazine and the apparent succesful use of the rescue drug nicardipine." | 9.20 | Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trial. ( Bijvank, SW; Duvekot, JJ; Edens, MA; Hanff, LM; Roofthooft, DW; Steegers, EA; Visser, W; Vulto, AG, 2015) |
| "Nicardipine and labetalol are effective and safe in the initial treatment of severe hypertension of pregnancy." | 9.10 | Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol. ( Abroug, F; Boussarssar, M; Elatrous, S; Marghli, S; Nouira, S; Ouanes Besbes, L; Sakkouhi, M, 2002) |
| "Our results suggest that long-term treatment with nicardipine for severe pre-eclampsia is as effective and safe as a short- and medium-term treatment." | 9.10 | Long-term treatment with nicardipine for severe pre-eclampsia. ( Kinoshita, K; Seki, H; Takeda, S, 2002) |
| "To assess the efficacy in lowering blood pressure, and the safety for mother and foetus of an acute nicardipine therapy in severe pre-eclampsia." | 9.09 | Intravenous nicardipine for severe hypertension in pre-eclampsia--effects of an acute treatment on mother and foetus. ( Aya, AG; Eledjam, JJ; Hoffet, M; Mangin, R, 1999) |
| "One hundred pregnant patients with mild or moderate hypertension followed at the Centre Hospitalier Intercommunal de Créteil (France) were randomly allocated to treatment with either nicardipine or metoprolol." | 9.07 | Nicardipine versus metoprolol in the treatment of hypertension during pregnancy: a randomized comparative trial. ( Carbonne, B; Jannet, D; Milliez, J; Sebban, E, 1994) |
| "Forty pregnant patients with mild or moderate hypertension received oral nicardipine 20 mg three times a day (mean duration of treatment 9 +/- 2." | 9.07 | Nicardipine treatment of hypertension during pregnancy. ( Carbonne, B; Jannet, D; Khelifati, Y; Milliez, J; Touboul, C, 1993) |
| "To evaluate the effect of two concentrations of intravenous administration of nicardipine hydrochloride on nicardipine-related phlebitis in patients with preeclampsia." | 8.12 | Clinical efficacy and safety of two concentrations of intravenous nicardipine hydrochloride for nicardipine-related phlebitis in patients with preeclampsia. ( Kong, B; Li, Y; Lu, Q; Ye, F, 2022) |
| "This multicenter, retrospective case series included all pregnant women beyond 20 weeks of gestation with severe antepartum hypertension that were treated with intravenous nicardipine." | 8.12 | Nicardipine for treating severe antepartum hypertension during pregnancy: Nine years of experience in more than 800 women. ( Cornette, JC; Duvekot, JJ; Edens, MA; Hengst, M; Huigen, S; Nij Bijvank, SW; Winkelen, AV, 2022) |
| "The authors report a heart failure and a collapse following concurrently administration of nicardipine and magnesium sulfate." | 7.78 | [Complications of association magnesium sulfate with nicardipine during preeclampsia: report of 2 cases]. ( Alassas, N; Carles, G; Dallah, F; Helou, J; Ibrahim, N, 2012) |
| "Nicardipine has been used extensively in different clinical settings including neurosurgery, cardiothoracic surgery, transplant medicine, and internal medicine patients." | 6.45 | Acute antihypertensive therapy in pregnancy-induced hypertension: is nicardipine the answer? ( Hankins, GD; Pacheco, LD; Vadhera, RB, 2009) |
| "Nicardipine was measured in maternal plasma (MP), umbilical cord arterial (UaP) and venous (UvP) plasma and breast milk (BrM) of 18 women with severe preeclampsia." | 5.40 | Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia. ( Fukatsu, M; Ichinose, S; Masuko, H; Matsumura, H; Mera, A; Miyashita, A; Ono, Y; Seki, H; Takagi, K, 2014) |
| " After 30 inclusions, the study was stopped because of the high rate of persistent hypertension using ketanserin and the high rate of maternal side effects using dihydralazine and the apparent succesful use of the rescue drug nicardipine." | 5.20 | Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trial. ( Bijvank, SW; Duvekot, JJ; Edens, MA; Hanff, LM; Roofthooft, DW; Steegers, EA; Visser, W; Vulto, AG, 2015) |
| "Nicardipine and labetalol are effective and safe in the initial treatment of severe hypertension of pregnancy." | 5.10 | Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol. ( Abroug, F; Boussarssar, M; Elatrous, S; Marghli, S; Nouira, S; Ouanes Besbes, L; Sakkouhi, M, 2002) |
| "Our results suggest that long-term treatment with nicardipine for severe pre-eclampsia is as effective and safe as a short- and medium-term treatment." | 5.10 | Long-term treatment with nicardipine for severe pre-eclampsia. ( Kinoshita, K; Seki, H; Takeda, S, 2002) |
| "To assess the efficacy in lowering blood pressure, and the safety for mother and foetus of an acute nicardipine therapy in severe pre-eclampsia." | 5.09 | Intravenous nicardipine for severe hypertension in pre-eclampsia--effects of an acute treatment on mother and foetus. ( Aya, AG; Eledjam, JJ; Hoffet, M; Mangin, R, 1999) |
| "One hundred pregnant patients with mild or moderate hypertension followed at the Centre Hospitalier Intercommunal de Créteil (France) were randomly allocated to treatment with either nicardipine or metoprolol." | 5.07 | Nicardipine versus metoprolol in the treatment of hypertension during pregnancy: a randomized comparative trial. ( Carbonne, B; Jannet, D; Milliez, J; Sebban, E, 1994) |
| "Forty pregnant patients with mild or moderate hypertension received oral nicardipine 20 mg three times a day (mean duration of treatment 9 +/- 2." | 5.07 | Nicardipine treatment of hypertension during pregnancy. ( Carbonne, B; Jannet, D; Khelifati, Y; Milliez, J; Touboul, C, 1993) |
| "To evaluate the effect of two concentrations of intravenous administration of nicardipine hydrochloride on nicardipine-related phlebitis in patients with preeclampsia." | 4.12 | Clinical efficacy and safety of two concentrations of intravenous nicardipine hydrochloride for nicardipine-related phlebitis in patients with preeclampsia. ( Kong, B; Li, Y; Lu, Q; Ye, F, 2022) |
| "This multicenter, retrospective case series included all pregnant women beyond 20 weeks of gestation with severe antepartum hypertension that were treated with intravenous nicardipine." | 4.12 | Nicardipine for treating severe antepartum hypertension during pregnancy: Nine years of experience in more than 800 women. ( Cornette, JC; Duvekot, JJ; Edens, MA; Hengst, M; Huigen, S; Nij Bijvank, SW; Winkelen, AV, 2022) |
| "Ten severely pre-eclamptic pregnant women who required intravenous nicardipine for severe hypertension were included in this prospective observational trial." | 3.83 | Hemodynamic effects of intravenous nicardipine in severely pre-eclamptic women with a hypertensive crisis. ( Buijs, EA; Cornette, J; Duvekot, JJ; Herzog, E; Meima, M; Rizopoulos, D; Roos-Hesselink, JW; Steegers, EA, 2016) |
| " She developed a prolonged and deep neuromuscular blockade, which was antagonized three hours later with neostigmine." | 3.83 | Prolonged neuromuscular block in a preeclamptic patient induced by magnesium sulfate. ( Berdai, MA; Harandou, M; Labib, S, 2016) |
| "The authors report a heart failure and a collapse following concurrently administration of nicardipine and magnesium sulfate." | 3.78 | [Complications of association magnesium sulfate with nicardipine during preeclampsia: report of 2 cases]. ( Alassas, N; Carles, G; Dallah, F; Helou, J; Ibrahim, N, 2012) |
| "The endpoints of the study were defined as the percentage of patients reaching the target diastolic intra-arterial blood pressure (< 100 mmHg or < 90 mmHg in Haemolysis, Elevated Liver Enzymes, Low Platelet Count syndrome patients) within 1 h after the start of treatment, and the number of days of prolongation of pregnancy under nicardipine treatment." | 3.73 | Intravenous use of the calcium-channel blocker nicardipine as second-line treatment in severe, early-onset pre-eclamptic patients. ( Bartels, PA; Bijvank, BN; Hanff, LM; Roofthooft, DW; Steegers, EA; Visser, W; Vulto, AG, 2005) |
| "We studied the effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam (a dopamine D1-agonist) on isolated human umbilical arteries (HUA) from patients classified as normotensive and with pregnancy-induced hypertension (PIH)." | 3.72 | The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. ( Arias, ME; Levy, JH; Sato, N; Szlam, F; Tanaka, KA; Tsuda, A, 2003) |
| " Fifteen patients with mild pre-eclampsia were chronically treated with oral pindolol." | 3.68 | The effect of acute and chronic antihypertensive therapy on maternal and fetoplacental Doppler velocimetry. ( Bjornsson, S; Cameron, AD; Fairlie, FM; Mathers, A; Walker, JJ, 1992) |
| "Risk factors for the development of preeclampsia include microvascular diseases, such as diabetes mellitus; vascular and connective tissue disorders; hypertension; antiphospholipid antibody syndrome; and nephropathy." | 2.45 | Pharmacotherapeutic options for the treatment of preeclampsia. ( Baldwin, K; McCoy, S, 2009) |
| "Nicardipine has been used extensively in different clinical settings including neurosurgery, cardiothoracic surgery, transplant medicine, and internal medicine patients." | 2.45 | Acute antihypertensive therapy in pregnancy-induced hypertension: is nicardipine the answer? ( Hankins, GD; Pacheco, LD; Vadhera, RB, 2009) |
| "Hypertension that complicates preeclampsia in pregnancy is a disorder that requires special consideration in both prevention and pharmacologic treatment." | 2.43 | Pathophysiology and medical management of systemic hypertension in preeclampsia. ( Frishman, WH; Schlocker, SJ; Tejani, N; Veresh, M, 2006) |
| "While nitroprusside is commonly used to treat severe hypertension, it is an extremely toxic drug that should only be used in rare circumstances." | 2.41 | The diagnosis and management of hypertensive crises. ( Marik, PE; Varon, J, 2000) |
| "Nicardipine was measured in maternal plasma (MP), umbilical cord arterial (UaP) and venous (UvP) plasma and breast milk (BrM) of 18 women with severe preeclampsia." | 1.40 | Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia. ( Fukatsu, M; Ichinose, S; Masuko, H; Matsumura, H; Mera, A; Miyashita, A; Ono, Y; Seki, H; Takagi, K, 2014) |
| " The highest umbilical cord concentration found after maternal dosage of 4." | 1.34 | Nicardipine in pre-eclamptic patients: placental transfer and disposition in breast milk. ( Bartels, PA; Hanff, LM; Mathot, RA; Steegers, EA; Visser, W; Vulto, AG, 2007) |
| "We report here four cases of pulmonary edema in pregnant women treated with nicardipine (Loxen) for preterm labor." | 1.34 | [Pulmonary edema during calcium-channel blockers therapy: role of predisposing or pharmacologic factors?]. ( Akerman, G; Cabrol, D; Goffinet, F; Jacqmin, S; Mignon, A; Tsatsaris, V, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, F | 1 |
| Lu, Q | 1 |
| Kong, B | 1 |
| Li, Y | 1 |
| Nij Bijvank, SW | 1 |
| Hengst, M | 1 |
| Cornette, JC | 1 |
| Huigen, S | 1 |
| Winkelen, AV | 1 |
| Edens, MA | 2 |
| Duvekot, JJ | 3 |
| Grandjean, B | 1 |
| Guerci, P | 1 |
| Raft, J | 1 |
| Fuchs-Buder, T | 1 |
| Bouaziz, H | 1 |
| Matsumura, H | 1 |
| Takagi, K | 1 |
| Seki, H | 2 |
| Ono, Y | 1 |
| Ichinose, S | 1 |
| Masuko, H | 1 |
| Fukatsu, M | 1 |
| Miyashita, A | 1 |
| Mera, A | 1 |
| Cornette, J | 1 |
| Buijs, EA | 1 |
| Herzog, E | 1 |
| Roos-Hesselink, JW | 1 |
| Rizopoulos, D | 1 |
| Meima, M | 1 |
| Steegers, EA | 4 |
| Bijvank, SW | 1 |
| Visser, W | 3 |
| Roofthooft, DW | 2 |
| Vulto, AG | 3 |
| Hanff, LM | 3 |
| Diemunsch, P | 2 |
| Garcia, V | 1 |
| Lyons, G | 1 |
| Pottecher, J | 1 |
| Emmanuel, S | 1 |
| Berdai, MA | 1 |
| Labib, S | 1 |
| Harandou, M | 1 |
| McCoy, S | 1 |
| Baldwin, K | 1 |
| Vadhera, RB | 1 |
| Pacheco, LD | 1 |
| Hankins, GD | 1 |
| Langer, B | 1 |
| Noll, E | 1 |
| Carles, G | 1 |
| Helou, J | 1 |
| Alassas, N | 1 |
| Dallah, F | 1 |
| Ibrahim, N | 1 |
| Elatrous, S | 1 |
| Nouira, S | 1 |
| Ouanes Besbes, L | 1 |
| Marghli, S | 1 |
| Boussarssar, M | 1 |
| Sakkouhi, M | 1 |
| Abroug, F | 1 |
| Sato, N | 1 |
| Tanaka, KA | 1 |
| Szlam, F | 1 |
| Tsuda, A | 1 |
| Arias, ME | 1 |
| Levy, JH | 1 |
| Bartels, PA | 2 |
| Bijvank, BN | 1 |
| Frishman, WH | 1 |
| Veresh, M | 1 |
| Schlocker, SJ | 1 |
| Tejani, N | 1 |
| Mathot, RA | 1 |
| Akerman, G | 1 |
| Mignon, A | 1 |
| Tsatsaris, V | 1 |
| Jacqmin, S | 1 |
| Cabrol, D | 1 |
| Goffinet, F | 1 |
| Jannet, D | 2 |
| Carbonne, B | 2 |
| Sebban, E | 1 |
| Milliez, J | 2 |
| Touboul, C | 1 |
| Khelifati, Y | 1 |
| Aya, AG | 1 |
| Mangin, R | 1 |
| Hoffet, M | 1 |
| Eledjam, JJ | 1 |
| Varon, J | 1 |
| Marik, PE | 1 |
| Takeda, S | 1 |
| Kinoshita, K | 1 |
| Walker, JJ | 1 |
| Mathers, A | 1 |
| Bjornsson, S | 1 |
| Cameron, AD | 1 |
| Fairlie, FM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Severe Hypertension During Pre-Eclampsia.A Preliminary Equivalence Study Between URAPIDIL and NICARDIPINE[NCT00409253] | Phase 3 | 72 participants (Anticipated) | Interventional | 2007-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for nicardipine and Pre-Eclampsia
| Article | Year |
|---|---|
Pharmacotherapeutic options for the treatment of preeclampsia.
Topics: Female; Humans; Hydralazine; Magnesium Sulfate; Nicardipine; Nifedipine; Nitroprusside; Pre-Eclampsi | 2009 |
Acute antihypertensive therapy in pregnancy-induced hypertension: is nicardipine the answer?
Topics: Acute Disease; Blood Pressure Determination; Calcium Channel Blockers; Dose-Response Relationship, D | 2009 |
[Intrahospital management of women with preeclampsia].
Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Antihypertensive Agents; Female; Fetal Mon | 2010 |
Pathophysiology and medical management of systemic hypertension in preeclampsia.
Topics: Adrenergic beta-Antagonists; Aspirin; Calcium; Calcium Channel Blockers; Cerebral Hemorrhage; Female | 2006 |
The diagnosis and management of hypertensive crises.
Topics: Antihypertensive Agents; Aortic Aneurysm; Aortic Dissection; Clonidine; Diazoxide; Enalaprilat; Fema | 2000 |
7 trials available for nicardipine and Pre-Eclampsia
| Article | Year |
|---|---|
Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trial.
Topics: Adult; Antihypertensive Agents; Dihydralazine; Double-Blind Method; Female; Gestational Age; Hospita | 2015 |
Urapidil versus nicardipine in preeclamptic toxaemia: A randomised feasibility study.
Topics: Antihypertensive Agents; Blood Pressure; Feasibility Studies; Female; Humans; Infant, Newborn; Nicar | 2015 |
Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol.
Topics: Adult; Antihypertensive Agents; Female; Humans; Hypertension; Labetalol; Nicardipine; Pre-Eclampsia; | 2002 |
Nicardipine versus metoprolol in the treatment of hypertension during pregnancy: a randomized comparative trial.
Topics: Adult; Birth Weight; Blood Pressure; Cesarean Section; Drug Administration Schedule; Female; Humans; | 1994 |
Nicardipine treatment of hypertension during pregnancy.
Topics: Administration, Oral; Adult; Blood Pressure; Female; Fetus; Heart Rate; Heart Rate, Fetal; Humans; H | 1993 |
Intravenous nicardipine for severe hypertension in pre-eclampsia--effects of an acute treatment on mother and foetus.
Topics: Acute Disease; Adult; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Drug Administra | 1999 |
Long-term treatment with nicardipine for severe pre-eclampsia.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Drug Administration Schedule; Female; Gestational Ag | 2002 |
12 other studies available for nicardipine and Pre-Eclampsia
| Article | Year |
|---|---|
Clinical efficacy and safety of two concentrations of intravenous nicardipine hydrochloride for nicardipine-related phlebitis in patients with preeclampsia.
Topics: Administration, Intravenous; Humans; Infusions, Intravenous; Nicardipine; Phlebitis; Pre-Eclampsia; | 2022 |
Nicardipine for treating severe antepartum hypertension during pregnancy: Nine years of experience in more than 800 women.
Topics: Antihypertensive Agents; Blood Pressure; Cesarean Section; Female; Humans; Hypertension; Hypotension | 2022 |
[Sugammadex and profound rocuronium neuromuscular blockade induced by magnesium sulphate].
Topics: Abortion, Therapeutic; Acetylcholine; Adult; Androstanols; Anesthesia, General; Calcium Signaling; E | 2013 |
Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia.
Topics: Adult; Antihypertensive Agents; Female; Fetal Blood; Humans; Infant, Newborn; Milk, Human; Nicardipi | 2014 |
Hemodynamic effects of intravenous nicardipine in severely pre-eclamptic women with a hypertensive crisis.
Topics: Administration, Intravenous; Adolescent; Adult; Antihypertensive Agents; Cardiac Output; Echocardiog | 2016 |
Prolonged neuromuscular block in a preeclamptic patient induced by magnesium sulfate.
Topics: Adult; Anesthesia, General; Cesarean Section; Female; HELLP Syndrome; Humans; Magnesium Sulfate; Neo | 2016 |
[Complications of association magnesium sulfate with nicardipine during preeclampsia: report of 2 cases].
Topics: Adolescent; Adult; Calcium Channel Blockers; Cesarean Section; Depression, Chemical; Drug Interactio | 2012 |
The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Dopamine; Dose-Response Relation | 2003 |
Intravenous use of the calcium-channel blocker nicardipine as second-line treatment in severe, early-onset pre-eclamptic patients.
Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Female; Fetus; | 2005 |
Nicardipine in pre-eclamptic patients: placental transfer and disposition in breast milk.
Topics: Adolescent; Adult; Antihypertensive Agents; Calcium Channel Blockers; Female; Fetal Blood; Humans; I | 2007 |
[Pulmonary edema during calcium-channel blockers therapy: role of predisposing or pharmacologic factors?].
Topics: Adult; Calcium Channel Blockers; Diabetes Mellitus, Type 1; Diseases in Twins; Female; Fetofetal Tra | 2007 |
The effect of acute and chronic antihypertensive therapy on maternal and fetoplacental Doppler velocimetry.
Topics: Blood Pressure; Brachial Artery; Female; Fetus; Humans; Hypertension; Infant, Newborn; Nicardipine; | 1992 |