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nicardipine and Neuroblastoma

nicardipine has been researched along with Neuroblastoma in 5 studies

Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
" In the present study, the protective effect of the calcium channel blocker nicardipine against rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells was investigated, focusing on mitogen‑activated protein kinases (MAPKs) and caspase (CASP)‑mediated apoptotic events."7.79Inhibitory effect of nicardipine on rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells. ( Kim, HJ; Park, HJ, 2013)
" In the present study, the protective effect of the calcium channel blocker nicardipine against rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells was investigated, focusing on mitogen‑activated protein kinases (MAPKs) and caspase (CASP)‑mediated apoptotic events."3.79Inhibitory effect of nicardipine on rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells. ( Kim, HJ; Park, HJ, 2013)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
An Haack, K1
Narayan, SB1
Li, H1
Warnock, A1
Tan, L1
Bennett, MJ1
Park, HJ1
Kim, HJ1
Carlson, RO1
Masco, D1
Brooker, G1
Spiegel, S1
Li, SN1
Bräter, M1
Andreas, K1
Yue, TL1
Gleason, MM1
Lysko, PG1
Feuerstein, G1

Other Studies

5 other studies available for nicardipine and Neuroblastoma

ArticleYear
Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers.
    Biochimica et biophysica acta, 2011, Volume: 1810, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2011
Inhibitory effect of nicardipine on rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells.
    Molecular medicine reports, 2013, Volume: 7, Issue:3

    Topics: Aniline Compounds; Apoptosis; bcl-2-Associated X Protein; Calcium; Calcium Channel Blockers; Caspase

2013
Endogenous ganglioside GM1 modulates L-type calcium channel activity in N18 neuroblastoma cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1994
Nicardipine inhibits N-type calcium channels in dbcAMP-differentiated neuroblastoma x glioma hybrid cells (NG 108-15 cells).
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:2

    Topics: Bucladesine; Calcium Channel Blockers; Calcium Channels; Cell Transformation, Neoplastic; Glioma; Hu

1999
Effect of endothelins on cytosolic free calcium concentration in neuroblastoma NG108-15 and NCB-20 cells.
    Neuropeptides, 1990, Volume: 17, Issue:1

    Topics: Animals; Bradykinin; Calcium; Cricetinae; Cytosol; Diltiazem; Endothelins; Fluorescent Dyes; Fluorom

1990