nicardipine has been researched along with Muscle Relaxation in 23 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relaxant effects of five organic calcium antagonists (nicardipine, diltiazem, PY 108068, verapamil and bepridil) on guinea-pig isolated trachea were tested against contractions induced by acetylcholine, histamine, 5-hydroxytryptamine, potassium chloride (KCl) and tetraethylammonium (TEA) in a medium containing the normal amount of calcium and against calcium dose-response curves in a calcium-free, potassium-enriched medium." | 1.27 | Effects of five different organic calcium antagonists on guinea-pig isolated trachea. ( Advenier, C; Cerrina, J; Duroux, P; Floch, A; Renier, A, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 11 (47.83) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janis, RA | 1 |
| Triggle, DJ | 1 |
| Gündüz, MG | 1 |
| Safak, C | 2 |
| Kaygısız, B | 1 |
| Koşar, BC | 1 |
| Simşek, R | 2 |
| Erol, K | 2 |
| Linden, A | 1 |
| Iizuka, T | 1 |
| Moriyama, H | 1 |
| Nagai, M | 1 |
| Nishikori, K | 1 |
| Takenaka, T | 1 |
| Maeno, H | 1 |
| Advenier, C | 3 |
| Cerrina, J | 1 |
| Duroux, P | 1 |
| Floch, A | 1 |
| Renier, A | 1 |
| Pouleur, H | 1 |
| Rousseau, MF | 1 |
| van Eyll, C | 1 |
| Charlier, AA | 1 |
| Takiguchi, M | 1 |
| Takaya, T | 1 |
| Kanda, M | 2 |
| Shirahase, H | 2 |
| Kurahashi, K | 1 |
| Wada, K | 2 |
| Nakamura, S | 2 |
| Matsui, H | 2 |
| Fukata, F | 2 |
| Masuda, Y | 1 |
| Miyajima, M | 1 |
| Shudo, C | 1 |
| Tanaka, S | 1 |
| Shigenobu, K | 1 |
| Kasuya, Y | 1 |
| Naline, E | 2 |
| Candenas, ML | 1 |
| Palette, C | 1 |
| Moreau, J | 1 |
| Norte, M | 1 |
| Martin, JD | 1 |
| Pays, M | 1 |
| Sarriá, B | 1 |
| Zhang, Y | 1 |
| Brisac, AM | 1 |
| Laurent, S | 1 |
| Cortijo, J | 1 |
| Shiraishi, Y | 1 |
| Ohashi, M | 1 |
| Kanmura, Y | 1 |
| Yamaguchi, S | 1 |
| Yoshimura, N | 1 |
| Itoh, T | 1 |
| Bayguinov, O | 1 |
| Sanders, KM | 1 |
| Tokutomi, Y | 1 |
| Tokutomi, N | 1 |
| Nishi, K | 1 |
| Sirmagül, B | 1 |
| Salom, JB | 1 |
| Burguete, MC | 1 |
| Pérez-Asensio, FJ | 1 |
| Centeno, JM | 1 |
| Torregrosa, G | 1 |
| Alborch, E | 1 |
| Toda, N | 1 |
| Baba, H | 1 |
| Tanobe, Y | 1 |
| Okamura, T | 1 |
| Fullarton, GM | 1 |
| Falconer, S | 1 |
| Campbell, A | 1 |
| Murray, WR | 1 |
| Stefański, R | 1 |
| Plaznik, A | 1 |
| Pałejko, W | 1 |
| Kostowski, W | 1 |
| Matsuo, K | 2 |
| Uchida, S | 1 |
| Uchida, MK | 1 |
| Jayakody, RL | 1 |
| Kappagoda, CT | 1 |
| Senaratne, MP | 1 |
| Sreeharan, N | 1 |
1 review available for nicardipine and Muscle Relaxation
| Article | Year |
|---|---|
New developments in Ca2+ channel antagonists.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calmodulin; Electrophysiology; Heart; Hum | 1983 |
1 trial available for nicardipine and Muscle Relaxation
| Article | Year |
|---|---|
Controlled study of the effect of nicardipine and ceruletide on the sphincter of Oddi.
Topics: Adult; Aged; Blood Pressure; Ceruletide; Female; Humans; Male; Manometry; Middle Aged; Muscle Relaxa | 1992 |
21 other studies available for nicardipine and Muscle Relaxation
| Article | Year |
|---|---|
Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Calcium Channels; Cyclopentanes; Female; Ileum; | 2012 |
Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium Channel Blockers; In Vitro Techniques; Male; Muscle R | 2006 |
A possible mechanism for relaxation of rat uterine smooth muscle by nicardipine hydrochloride (YC-93), a new potent vasodilator.
Topics: Adenosine Triphosphatases; Adenylyl Cyclases; Animals; Female; In Vitro Techniques; Microsomes; Musc | 1981 |
Effects of five different organic calcium antagonists on guinea-pig isolated trachea.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Calcium Channel Blockers; Diltiazem; Dose-Response Relati | 1984 |
Assessment of regional left ventricular relaxation in patients with coronary artery disease: importance of geometric factors and changes in wall thickness.
Topics: Adult; Aged; Coronary Disease; Heart Ventricles; Humans; Middle Aged; Muscle Relaxation; Nicardipine | 1984 |
Potentiation of neuromuscular blockade by calcium channel blockers.
Topics: Adult; Aged; Calcium; Drug Synergism; Evoked Potentials; Female; Humans; Male; Middle Aged; Muscle R | 1994 |
Effects of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride on the responses of isolated canine arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Cardiovascular selectivity of 1,4-dihydropyridine derivatives, efonidipine (NZ-105), nicardipine and structure related compounds in isolated guinea-pig tissues.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Atrial Function; Calcium Channel Blockers; Depres | 1995 |
Effects of okadaic acid on the human isolated bronchus.
Topics: Acetylcholine; Bronchi; Cadmium; Cadmium Compounds; Caffeine; Dose-Response Relationship, Drug; Ethe | 1994 |
The nicardipine-isoprenaline interaction in human and guinea-pig isolated airways.
Topics: Adenosine; Animals; Bronchi; Colforsin; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pig | 1994 |
Effects of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride on the endothelium-independent and endothelium-dependent c
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Calcium Channel Blockers; Cerebral Arteries; Dihydrop | 1996 |
Possible mechanisms underlying the midazolam-induced relaxation of the noradrenaline-contraction in rabbit mesenteric resistance artery.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; In Vitro Techniques; Male; Membrane Potentials | 1997 |
Dissociation between electrical and mechanical responses to nitrergic stimulation in the canine gastric fundus.
Topics: Animals; Arginine; Atropine; Calcium; Cytosol; Dogs; Electric Stimulation; Female; Gastric Fundus; G | 1998 |
The properties of ryanodine-sensitive Ca(2+) release in mouse gastric smooth muscle cells.
Topics: Animals; Bucladesine; Caffeine; Calcium; Carbachol; Cells, Cultured; Dose-Response Relationship, Dru | 2001 |
Synthesis of hexahydroquinoline derivatives possessing calcium antagonistic activity.
Topics: Animals; Calcium Channel Blockers; Female; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mal | 2001 |
Acute relaxant effects of 17-beta-estradiol through non-genomic mechanisms in rabbit carotid artery.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Carotid Arteries; En | 2002 |
Mechanism of relaxation induced by K+ and nicotine in dog duodenal longitudinal muscle.
Topics: Adenosine Triphosphate; Animals; Apamin; Atropine; Bradykinin; Cations, Monovalent; Cyclic GMP; Dogs | 1992 |
Myorelaxant effect of baclofen injected to the nucleus accumbens septi.
Topics: Animals; Baclofen; Behavior, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Halo | 1990 |
[Synergism of the calcium reversal phenomenon of potassium depolarizing in the rat uterine muscle by Bay k-8644, a calcium agonist].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
Opposite effects of Bay k 8644 and nicardipine on the inhibitory effect of Ca2+ on rat myometrium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Absence of effect of calcium antagonists on endothelium-dependent relaxation in rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Endothelium; In Vitro | 1987 |