nicardipine has been researched along with Kidney Failure in 3 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Kidney Failure: A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the renoprotective effect of nicardipine in patients with pre-existing renal insufficiency undergoing robot-assisted laparoscopic radical prostatectomy (RALRP)." | 9.19 | Effect of nicardipine on renal function following robot-assisted laparoscopic radical prostatectomy in patients with pre-existing renal insufficiency. ( Cho, JE; Huh, H; Kim, NY; Park, SJ, 2014) |
| " Food and Drug Administration (FDA)-recommended doses of labetalol and nicardipine for hypertension (HTN) management in a subset of patients with renal dysfunction (RD)." | 9.19 | The management of acute hypertension in patients with renal dysfunction: labetalol or nicardipine? ( Baumann, BM; Borczuk, P; Cannon, CM; Chandra, A; Cline, DM; Diercks, DB; Hiestand, B; Hsu, A; Jois-Bilowich, P; Kaminski, B; Levy, P; Nowak, RM; Peacock, WF; Schrock, JW; Soto-Ruiz, KM; Varon, J, 2014) |
| "To investigate the renoprotective effect of nicardipine in patients with pre-existing renal insufficiency undergoing robot-assisted laparoscopic radical prostatectomy (RALRP)." | 5.19 | Effect of nicardipine on renal function following robot-assisted laparoscopic radical prostatectomy in patients with pre-existing renal insufficiency. ( Cho, JE; Huh, H; Kim, NY; Park, SJ, 2014) |
| " Food and Drug Administration (FDA)-recommended doses of labetalol and nicardipine for hypertension (HTN) management in a subset of patients with renal dysfunction (RD)." | 5.19 | The management of acute hypertension in patients with renal dysfunction: labetalol or nicardipine? ( Baumann, BM; Borczuk, P; Cannon, CM; Chandra, A; Cline, DM; Diercks, DB; Hiestand, B; Hsu, A; Jois-Bilowich, P; Kaminski, B; Levy, P; Nowak, RM; Peacock, WF; Schrock, JW; Soto-Ruiz, KM; Varon, J, 2014) |
| "Continuous infusion of low-dose nicardipine during RALRP seems to offset the deleterious effects of inevitable pneumoperitoneum and extreme head-down tilt on renal function in preserving the eGFR and attenuating the development of renal insufficiency in the immediate postoperative period." | 5.14 | Effect of nicardipine on renal function after robot-assisted laparoscopic radical prostatectomy. ( Chang, JH; Cho, JE; Kil, HK; Kwak, YL; Oh, YJ; Rha, KH; Shim, JK, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huh, H | 1 |
| Kim, NY | 1 |
| Park, SJ | 1 |
| Cho, JE | 2 |
| Varon, J | 1 |
| Soto-Ruiz, KM | 1 |
| Baumann, BM | 1 |
| Borczuk, P | 1 |
| Cannon, CM | 1 |
| Chandra, A | 1 |
| Cline, DM | 1 |
| Diercks, DB | 1 |
| Hiestand, B | 1 |
| Hsu, A | 1 |
| Jois-Bilowich, P | 1 |
| Kaminski, B | 1 |
| Levy, P | 1 |
| Nowak, RM | 1 |
| Schrock, JW | 1 |
| Peacock, WF | 1 |
| Shim, JK | 1 |
| Chang, JH | 1 |
| Oh, YJ | 1 |
| Kil, HK | 1 |
| Rha, KH | 1 |
| Kwak, YL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase IV, Randomized Trial to Determine the Efficacy and Safety of Cardene Intravenous (I.V.) Versus Labetalol for Management of Hypertensive Emergencies in the Emergency Department Setting[NCT00765648] | Phase 4 | 226 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Calculated as the mean (± standard deviation) number of titrations over 30 minutes for each treatment group (NCT00765648)
Timeframe: 30 minutes
| Intervention | number of titrations (Mean) |
|---|---|
| Nicardipine | 2.2 |
| Labetalol | 1.3 |
Median number of hours from hospital admission until Emergency Department(ED)disposition (NCT00765648)
Timeframe: 6 hours
| Intervention | hours (Median) |
|---|---|
| Nicardipine | 4.6 |
| Labetalol | 4.6 |
Percentage of subjects achieving a pre-defined target systolic blood pressure (BP) range defined as a systolic blood pressure that is within +/- 20 mmHg of the target as established by the investigator. (NCT00765648)
Timeframe: 30 minutes after initiation of therapy
| Intervention | percentage of participants (Number) |
|---|---|
| Nicardipine | 91.7 |
| Labetalol | 82.5 |
The percent of subjects requiring the use of intravenous rescue medications (NCT00765648)
Timeframe: 6 hours
| Intervention | percentage of participants (Number) |
|---|---|
| Nicardipine | 15.5 |
| Labetalol | 22.4 |
The median transition time (in hours) to oral medication (NCT00765648)
Timeframe: 6 hours
| Intervention | hours (Median) |
|---|---|
| Nicardipine | 4.9 |
| Labetalol | 6.4 |
Treatment failure is defined as admission to the hospital or observation unit for BP management (NCT00765648)
Timeframe: 6 hours
| Intervention | percentage of participants (Number) |
|---|---|
| Nicardipine | 43.1 |
| Labetalol | 37.4 |
3 trials available for nicardipine and Kidney Failure
| Article | Year |
|---|---|
Effect of nicardipine on renal function following robot-assisted laparoscopic radical prostatectomy in patients with pre-existing renal insufficiency.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Creatinine; Glomerular F | 2014 |
The management of acute hypertension in patients with renal dysfunction: labetalol or nicardipine?
Topics: Acute Disease; Antihypertensive Agents; Comorbidity; Double-Blind Method; Female; Humans; Hypertensi | 2014 |
Effect of nicardipine on renal function after robot-assisted laparoscopic radical prostatectomy.
Topics: Aged; Creatinine; Follow-Up Studies; Glomerular Filtration Rate; Humans; Infusions, Intravenous; Kid | 2009 |