nicardipine has been researched along with Ischemic Attack, Transient in 58 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-dose intravenous nicardipine has been shown to reduce the incidence of angiographic and symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (SAH), but treatment may be complicated by side effects, including hypotension or pulmonary edema/azotemia." | 9.07 | A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study. ( Germanson, TP; Haley, EC; Kassell, NF; Torner, JC; Truskowski, LL, 1994) |
| "To describe a patient who developed reversible segmental cerebral arterial vasospasm and cerebral infarction while taking excessive amounts of sumatriptan succinate and a combination drug (Midrin) consisting of isometheptene mucate, 65 mg, dichloralphenazone, 100 mg, and acetaminophen, 325 mg." | 8.80 | Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin. ( Biller, J; Malkoff, MD; Meschia, JF, 1998) |
| "The effect of high dose nicardipine on delayed cerebral vasospasm was studied in 33 patients with aneurysmal subarachnoid hemorrhage (SAH)." | 7.68 | [High dose nicardipine therapy for delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage]. ( Honma, T; Kawano, T; Kohno, H; Okada, T; Satoh, K; Tanaka, N, 1993) |
| "The effect of the dihydropyridine calcium antagonist, nicardipine, on the vasoactive responses of the basilar artery was investigated after subarachnoid hemorrhage (SAH)." | 7.68 | Effect of nicardipine on basilar artery vasoactive responses after subarachnoid hemorrhage. ( Kassell, NF; Pasqualin, A; Torner, JC; Tsukahara, T, 1992) |
| "This report describes the successful treatment of cerebral vasospasm after subarachnoid hemorrhage with superselective intra-arterial infusion of papaverine hydrochloride." | 7.68 | Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. ( Kaku, Y; Kazekawa, K; Tsukahara, T; Yonekawa, Y, 1992) |
| "This study was performed to examine the effect of the dihydropyridine calcium antagonist, nicardipine, on vasospasm after experimental subarachnoid hemorrhage (SAH) in the rabbit." | 7.68 | The effect of nicardipine on vasospasm in rabbit basilar artery after subarachnoid hemorrhage. ( Kassell, NF; Marron, JA; Pasqualin, A; Torner, JC; Tsukahara, T; Vollmer, DG, 1991) |
| " During anaesthesia for intracranial aneurysm surgery, we prospectively compared haemodynamic values obtained from 13 patients being treated with nicardipine HCl (0." | 7.67 | Nicardipine HCl: clinical experience in patients undergoing anaesthesia for intracranial aneurysm clipping. ( Adams, HP; Godersky, JC; Maktabi, M; Sokoll, MD; Warner, DS, 1989) |
| "A dose-escalation study of the calcium ion entry blocking drug nicardipine was performed using large dose infusions in 67 patients with recent aneurysmal subarachnoid hemorrhage (SAH)." | 7.67 | Dose-escalation study of intravenous nicardipine in patients with aneurysmal subarachnoid hemorrhage. ( Adams, HP; Beck, DW; Biller, J; Boarini, DJ; Flamm, ES; Godersky, JC; Loftus, CM; Marler, JR; Pinto, RS; Walker, MD, 1988) |
| "Hypotension was the main side effect, and it occurred only in the two groups that received the highest doses." | 6.67 | Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study. ( Bourdeix, I; Chaumet-Riffaud, P; Massiou, H, 1992) |
| "High-dose intravenous nicardipine has been shown to reduce the incidence of angiographic and symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (SAH), but treatment may be complicated by side effects, including hypotension or pulmonary edema/azotemia." | 5.07 | A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study. ( Germanson, TP; Haley, EC; Kassell, NF; Torner, JC; Truskowski, LL, 1994) |
| "To describe a patient who developed reversible segmental cerebral arterial vasospasm and cerebral infarction while taking excessive amounts of sumatriptan succinate and a combination drug (Midrin) consisting of isometheptene mucate, 65 mg, dichloralphenazone, 100 mg, and acetaminophen, 325 mg." | 4.80 | Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin. ( Biller, J; Malkoff, MD; Meschia, JF, 1998) |
| "The effect of high dose nicardipine on delayed cerebral vasospasm was studied in 33 patients with aneurysmal subarachnoid hemorrhage (SAH)." | 3.68 | [High dose nicardipine therapy for delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage]. ( Honma, T; Kawano, T; Kohno, H; Okada, T; Satoh, K; Tanaka, N, 1993) |
| "The effect of the dihydropyridine calcium antagonist, nicardipine, on the vasoactive responses of the basilar artery was investigated after subarachnoid hemorrhage (SAH)." | 3.68 | Effect of nicardipine on basilar artery vasoactive responses after subarachnoid hemorrhage. ( Kassell, NF; Pasqualin, A; Torner, JC; Tsukahara, T, 1992) |
| "This report describes the successful treatment of cerebral vasospasm after subarachnoid hemorrhage with superselective intra-arterial infusion of papaverine hydrochloride." | 3.68 | Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. ( Kaku, Y; Kazekawa, K; Tsukahara, T; Yonekawa, Y, 1992) |
| "This study was performed to examine the effect of the dihydropyridine calcium antagonist, nicardipine, on vasospasm after experimental subarachnoid hemorrhage (SAH) in the rabbit." | 3.68 | The effect of nicardipine on vasospasm in rabbit basilar artery after subarachnoid hemorrhage. ( Kassell, NF; Marron, JA; Pasqualin, A; Torner, JC; Tsukahara, T; Vollmer, DG, 1991) |
| "We examined the efficacy of slow-release, and prolonged diffusion silicone pellets mixed with papaverine hydrochloride in the treatment of cerebral vasospasms following subarachnoid hemorrhage." | 3.67 | [Sustained-release pellet of vasodilators--basic experiment]. ( Arimitsu, T; Mori, K; Oda, Y; Okumura, T, 1984) |
| " During anaesthesia for intracranial aneurysm surgery, we prospectively compared haemodynamic values obtained from 13 patients being treated with nicardipine HCl (0." | 3.67 | Nicardipine HCl: clinical experience in patients undergoing anaesthesia for intracranial aneurysm clipping. ( Adams, HP; Godersky, JC; Maktabi, M; Sokoll, MD; Warner, DS, 1989) |
| "The efficacy of intravenous nicardipine in the prevention of vasospasm after subarachnoid hemorrhage has been investigated in a dose escalation study in 67 patients admitted within 1 week of subarachnoid hemorrhage." | 3.67 | The potential use of nicardipine in cerebrovascular disease. ( Flamm, ES, 1989) |
| "A dose-escalation study of the calcium ion entry blocking drug nicardipine was performed using large dose infusions in 67 patients with recent aneurysmal subarachnoid hemorrhage (SAH)." | 3.67 | Dose-escalation study of intravenous nicardipine in patients with aneurysmal subarachnoid hemorrhage. ( Adams, HP; Beck, DW; Biller, J; Boarini, DJ; Flamm, ES; Godersky, JC; Loftus, CM; Marler, JR; Pinto, RS; Walker, MD, 1988) |
| "Hypotension was the main side effect, and it occurred only in the two groups that received the highest doses." | 2.67 | Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study. ( Bourdeix, I; Chaumet-Riffaud, P; Massiou, H, 1992) |
| "In a rat model of transient cerebral ischemia and reperfusion, we evaluated the effect of the calcium antagonist, nicardipine, on intracranial pressure (ICP)." | 1.35 | Intravenous infusion of calcium antagonist, nicardipine, does not increase intracranial pressure: evaluation in a rat model of transient cerebral ischemia and reperfusion. ( Harada, T; Kano, T; Katayama, Y; Matsuzaki, T; Nakamura, S, 2008) |
| "(Stroke 17, 472-476, 1986) and cerebral infarct size (CIS) determined by the 2,3,5-triphenyltetrazolium chloride staining method were measured 24 hr after MCAO." | 1.30 | Effects of a calcium antagonist, lacidipine, on experimental focal cerebral ischemia in rats. ( Akada, Y; Funato, H; Katsuki, Y; Kawano, H; Sato, M; Uemura, A, 1997) |
| "Nicardipine treatment normalized PDH activity quickly and improved energy metabolism after reperfusion." | 1.30 | Effect of nicardipine, a Ca2+ channel blocker, on pyruvate dehydrogenase activity and energy metabolites during cerebral ischemia and reperfusion in gerbil brain. ( Fukuchi, T; Katayama, Y; McKee, A; Terashi, A, 1998) |
| "Hypertension is a primary aggravating factor in cerebral infarction." | 1.29 | M1 receptors in blood pressure-controlled ischemic spontaneously hypertensive rats. ( Asanuma, M; Hirata, H; Kondo, Y; Ogawa, N; Tanaka, K, 1995) |
| "There were no further episodes of transient ischemic attacks, seizures, or headache in one patient and decreased frequency in the other." | 1.29 | Use of a calcium channel blocker (nicardipine HCl) in the treatment of childhood moyamoya disease. ( Fish, I; Forem, SL; Hosain, SA; Hughes, JT; Wisoff, J, 1994) |
| "As soon as the subarachnoid hemorrhage diagnosis is confirmed by computed tomography (or if unconfirmed, by lumbar puncture), we assume that each patient may have an aneurysm." | 1.29 | Are the calcium antagonists really useful in cerebral aneurysmal surgery? A retrospective study. ( Alhayek, G; Fournier, D; Guy, G; Menei, P; Mercier, P; Rizk, T, 1994) |
| "In addition, evolution of cerebral infarction was studied at 6 hours and 12 hours post-occlusion by magnetic resonance imaging (MRI)." | 1.28 | [Ca++ antagonist and acute brain ischemia: effects of nilvadipine and nicardipine on middle cerebral artery occlusion in rats]. ( Handa, J; Inubushi, T; Kido, C; Matsuda, M; Morikawa, S; Shiino, A; Susumu, T, 1991) |
| "Nicardipine-treated animals had significantly less calcium-calmodulin binding in CA1 and in the dentate after 2 hours of reperfusion." | 1.28 | Calcium-calmodulin binding in ischemic rat neurons after calcium channel blocker therapy. ( Dedman, JR; Earls, R; Grotta, JC; Picone, CM; Strong, R; Yao, L, 1990) |
| "Nicardipine was given by slow intravenous injection." | 1.27 | Baroreflex sensitivity alteration following transient hemispheric ischaemia in rats: protective effect of alphamethyldopa and guanfacine. ( Elghozi, JL; Meyer, P; Saad, MA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (22.41) | 18.7374 |
| 1990's | 44 (75.86) | 18.2507 |
| 2000's | 1 (1.72) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuzaki, T | 1 |
| Kano, T | 1 |
| Katayama, Y | 2 |
| Nakamura, S | 1 |
| Harada, T | 1 |
| Okumura, T | 1 |
| Oda, Y | 1 |
| Arimitsu, T | 1 |
| Mori, K | 1 |
| Kataoka, K | 1 |
| Niiyama, K | 1 |
| Uejima, T | 1 |
| Kuroda, R | 1 |
| Ioku, M | 1 |
| Yamada, K | 2 |
| Taneda, M | 1 |
| Hayakawa, T | 1 |
| Hirata, H | 1 |
| Asanuma, M | 1 |
| Tanaka, K | 1 |
| Kondo, Y | 1 |
| Ogawa, N | 1 |
| Shibuya, M | 2 |
| Suzuki, Y | 2 |
| Enomoto, H | 1 |
| Okada, T | 2 |
| Ogura, K | 1 |
| Sugita, K | 1 |
| Macdonald, RL | 1 |
| Zhang, J | 1 |
| Han, H | 1 |
| Hosain, SA | 1 |
| Hughes, JT | 1 |
| Forem, SL | 1 |
| Wisoff, J | 1 |
| Fish, I | 1 |
| Kitano, H | 1 |
| Matsuda, M | 2 |
| Hongo, K | 1 |
| Kobayashi, S | 2 |
| Weir, B | 1 |
| MacDonald, L | 1 |
| Nishizawa, Y | 2 |
| Mercier, P | 1 |
| Alhayek, G | 1 |
| Rizk, T | 1 |
| Fournier, D | 1 |
| Menei, P | 1 |
| Guy, G | 1 |
| Haley, EC | 3 |
| Kassell, NF | 5 |
| Torner, JC | 5 |
| Truskowski, LL | 1 |
| Germanson, TP | 1 |
| Nakamura, K | 1 |
| Hatakeyama, T | 1 |
| Furuta, S | 1 |
| Sakaki, S | 1 |
| Kohno, H | 1 |
| Kawano, T | 1 |
| Tanaka, N | 1 |
| Honma, T | 1 |
| Satoh, K | 1 |
| Matsui, T | 2 |
| Kaizu, H | 1 |
| Itoh, S | 1 |
| Asano, T | 3 |
| Kurihara, J | 1 |
| Ochiai, N | 1 |
| Kato, H | 1 |
| Tuncer, R | 1 |
| Yoshimura, S | 1 |
| Tsukahara, T | 4 |
| Hashimoto, N | 1 |
| Kazekawa, K | 2 |
| Kobayashi, A | 1 |
| Melon, E | 3 |
| Rimaniol, JM | 1 |
| Nishida, K | 1 |
| Markey, SP | 1 |
| Funato, H | 2 |
| Katsuki, Y | 2 |
| Yano, T | 1 |
| Kawano, H | 3 |
| Akada, Y | 2 |
| Sato, M | 2 |
| Uemura, A | 2 |
| Kittaka, M | 1 |
| Giannotta, SL | 1 |
| Zelman, V | 1 |
| Correale, JD | 1 |
| DeGiorgio, CM | 1 |
| Weiss, MH | 1 |
| Zlokovic, BV | 1 |
| Kawashima, A | 1 |
| Kasuya, H | 1 |
| Shiokawa, K | 1 |
| Miyajima, M | 1 |
| Izawa, M | 1 |
| Takakura, K | 1 |
| Fukuchi, T | 1 |
| McKee, A | 1 |
| Terashi, A | 1 |
| Meschia, JF | 1 |
| Malkoff, MD | 1 |
| Biller, J | 2 |
| Miyazaki, H | 1 |
| Tanaka, S | 1 |
| Fujii, Y | 1 |
| Shimizu, K | 1 |
| Nagashima, K | 1 |
| Kamibayashi, M | 1 |
| Uehara, T | 1 |
| Okuma, Y | 1 |
| Nomura, Y | 1 |
| Pasqualin, A | 2 |
| Kaku, Y | 1 |
| Yonekawa, Y | 1 |
| Alborch, E | 1 |
| Salom, JB | 1 |
| Perales, AJ | 1 |
| Torregrosa, G | 1 |
| Miranda, FJ | 1 |
| Alabadí, JA | 1 |
| Jover, T | 1 |
| Combes, P | 1 |
| Fauvage, B | 1 |
| Massiou, H | 1 |
| Chaumet-Riffaud, P | 1 |
| Bourdeix, I | 1 |
| Toyota, A | 1 |
| Shiino, A | 1 |
| Handa, J | 1 |
| Morikawa, S | 1 |
| Kido, C | 1 |
| Inubushi, T | 1 |
| Susumu, T | 1 |
| Marzatico, F | 1 |
| Gaetani, P | 1 |
| Spanu, G | 1 |
| Buratti, E | 1 |
| Rodriguez y Baena, R | 1 |
| Vollmer, DG | 1 |
| Marron, JA | 1 |
| Sugawa, M | 1 |
| Johshita, H | 1 |
| Takuwa, Y | 1 |
| Toda, N | 1 |
| Kawakami, M | 1 |
| Kodama, N | 1 |
| Compton, JS | 1 |
| Lee, T | 1 |
| Jones, NR | 1 |
| Waddell, G | 1 |
| Teddy, PJ | 1 |
| Kobayashi, H | 1 |
| Hayashi, M | 1 |
| Kabuto, M | 1 |
| Handa, Y | 1 |
| Adams, HP | 3 |
| Dote, K | 1 |
| Grotta, JC | 1 |
| Picone, CM | 1 |
| Earls, R | 1 |
| Strong, R | 1 |
| Yao, L | 1 |
| Dedman, JR | 1 |
| Warner, DS | 1 |
| Sokoll, MD | 1 |
| Maktabi, M | 1 |
| Godersky, JC | 2 |
| Picard-Claret, M | 1 |
| Abhay, KP | 1 |
| Nguyen, JP | 2 |
| Gaston, A | 2 |
| Flamm, ES | 2 |
| Saad, MA | 1 |
| Elghozi, JL | 1 |
| Meyer, P | 1 |
| Marín Gámez, N | 1 |
| Soto Mas, JA | 1 |
| Aguilar Martínez, JL | 1 |
| Bermúdez García, JM | 1 |
| Salim, A | 1 |
| Ramos Jiménez, A | 1 |
| Gil Extremera, B | 1 |
| Beck, DW | 1 |
| Pinto, RS | 1 |
| Marler, JR | 1 |
| Walker, MD | 1 |
| Loftus, CM | 1 |
| Boarini, DJ | 1 |
| Fujita, K | 1 |
| Yamashita, H | 1 |
| Masumura, M | 1 |
| Ehara, K | 1 |
| Tamaki, N | 1 |
| Matsumoto, S | 1 |
| Alps, BJ | 1 |
| Hass, WK | 1 |
| Oki, S | 1 |
| Kobayashi, M | 1 |
| Yoshihara, T | 1 |
| Sakoda, K | 1 |
| Uozumi, T | 1 |
| Ikegaki, I | 1 |
| Satoh, S | 1 |
| Takayasu, M | 1 |
| Hidaka, H | 1 |
| Homs, JB | 1 |
| Lepresle, E | 1 |
| Rostaing, S | 1 |
| Février, MJ | 1 |
| Wilmart, P | 1 |
| Payen, D | 1 |
| Lamer, C | 1 |
| Chiron, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Subarachnoid Hemorrhage With Human Albumin[NCT00283400] | 47 participants (Actual) | Interventional | 2006-01-31 | Terminated (stopped due to Study met safety endpoints) | |||
| Efficacy and Safety of Cilostazol-Nimodipine Combined Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage (aSAH): A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial[NCT04148105] | Phase 4 | 120 participants (Anticipated) | Interventional | 2019-11-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of subjects with good clinical outcome defined as a Glasgw Outcome Scale score of 0-1 (NCT00283400)
Timeframe: 3 months after enrollment
| Intervention | participants (Number) |
|---|---|
| Dosage Tier 1 | 13 |
| Dosage Tier 2 | 17 |
| Dosage Tier 3 | 3 |
Tolerability outcome: Subject's ability to receive the full allocated human albumin dose without incurring frank congestive heart failure or experiencing anaphylactic reactions that required discontinuation of the treatment. Study would be terminated if 2 or more subjects developed severe or life-threatening heart failure considered to be related (probably, possibly, and definitely) to albumin treatment. (NCT00283400)
Timeframe: 9 days after enrollment
| Intervention | participants (Number) |
|---|---|
| Dosage Tier 1 | 0 |
| Dosage Tier 2 | 1 |
| Dosage Tier 3 | 2 |
"Serious adverse events included neurological and medical complications and neurological deterioration.~Neurological deterioration was defined as a decline by more than 2 points in the Glasgow Coma Scale." (NCT00283400)
Timeframe: within 3 months after enrollment
| Intervention | participants (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Symptomatic Cerebral Vasospasm | Pulmonary Edema | ARDS | Rebleeding | Pulmonary Embolism | Gram-Negative Ventriculitis | Hypotension due to sepsis | |
| Dosage Tier 1 | 4 | 2 | 0 | 1 | 1 | 1 | 1 |
| Dosage Tier 2 | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| Dosage Tier 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 |
5 reviews available for nicardipine and Ischemic Attack, Transient
| Article | Year |
|---|---|
Calcium antagonists for the treatment of vasospasm following subarachnoid haemorrhage.
Topics: Animals; Calcium Channel Blockers; Cerebrovascular Circulation; Diltiazem; Humans; Ischemic Attack, | 1993 |
Cerebral vasospasm.
Topics: Aneurysm, Ruptured; Blood Pressure; Blood Volume; Brain Ischemia; Catheterization; Cerebral Infarcti | 1993 |
[Pharmacological treatment of vasospasm in subarachnoid hemorrhage].
Topics: Antioxidants; Humans; Ischemic Attack, Transient; Lipid Peroxides; Male; Nicardipine; Nimodipine; Pa | 1996 |
Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin.
Topics: Acetaminophen; Adult; Antipyrine; Cerebral Infarction; Chloral Hydrate; Drug Combinations; Drug Ther | 1998 |
Calcium antagonists in the management of patients with aneurysmal subarachnoid hemorrhage: a review.
Topics: Calcium Channel Blockers; Cerebral Infarction; Humans; Intracranial Aneurysm; Ischemic Attack, Trans | 1990 |
8 trials available for nicardipine and Ischemic Attack, Transient
| Article | Year |
|---|---|
Effects of prophylactic intrathecal administrations of nicardipine on vasospasm in patients with severe aneurysmal subarachnoid haemorrhage.
Topics: Adult; Aged; Aneurysm, Ruptured; Basilar Artery; Cerebral Angiography; Female; Humans; Injections, S | 1994 |
A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; | 1994 |
A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Incidence; Infusions, Intravenous; I | 1993 |
A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Incidence; Infusions, Intravenous; I | 1993 |
A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Incidence; Infusions, Intravenous; I | 1993 |
A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Incidence; Infusions, Intravenous; I | 1993 |
A randomized trial of nicardipine in subarachnoid hemorrhage: angiographic and transcranial Doppler ultrasound results. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Humans; Infusions, Intravenous; Ischemic Attack, Transient; Male | 1993 |
Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study.
Topics: Administration, Oral; Adult; Aged; Chi-Square Distribution; Female; Humans; Hypotension; Infusions, | 1992 |
A double blind placebo controlled trial of the calcium entry blocking drug, nicardipine, in the treatment of vasospasm following severe head injury.
Topics: Adolescent; Adult; Aged; Blood Flow Velocity; Child; Confounding Factors, Epidemiologic; Craniocereb | 1990 |
Calcium antagonists in the management of patients with aneurysmal subarachnoid hemorrhage: a review.
Topics: Calcium Channel Blockers; Cerebral Infarction; Humans; Intracranial Aneurysm; Ischemic Attack, Trans | 1990 |
[A double-blind controlled clinical trial of nicardipine versus placebo in acute cerebral focal ischemia].
Topics: Acute Disease; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ischemic Attack, | 1988 |
46 other studies available for nicardipine and Ischemic Attack, Transient
| Article | Year |
|---|---|
Intravenous infusion of calcium antagonist, nicardipine, does not increase intracranial pressure: evaluation in a rat model of transient cerebral ischemia and reperfusion.
Topics: Analysis of Variance; Animals; Blood Pressure; Brain Infarction; Calcium Channel Blockers; Disease M | 2008 |
[Sustained-release pellet of vasodilators--basic experiment].
Topics: Delayed-Action Preparations; Diltiazem; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; N | 1984 |
Treatment of severe localized cerebral vasospasm following recurrent hemorrhage from middle cerebral artery aneurysm--case report.
Topics: Brain; Cerebral Angiography; Cerebral Arteries; Female; Humans; Intracranial Aneurysm; Ischemic Atta | 1993 |
M1 receptors in blood pressure-controlled ischemic spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Cerebrovascular Disorders; Frontal Lobe; Hippo | 1995 |
Angioplasty reduces pharmacologically mediated vasoconstriction in rabbit carotid arteries with and without vasospasm.
Topics: Acetylcholine; Analysis of Variance; Angioplasty; Animals; Carotid Arteries; In Vitro Techniques; Is | 1995 |
Use of a calcium channel blocker (nicardipine HCl) in the treatment of childhood moyamoya disease.
Topics: Carotid Stenosis; Cerebral Angiography; Cerebral Infarction; Cerebral Revascularization; Child; Comb | 1994 |
[Effect of high dose nicardipine in patients with ruptured cerebral aneurysm].
Topics: Adult; Aged; Aneurysm, Ruptured; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; | 1993 |
[The pathogenesis and the preventive treatment of cerebral vasospasm following subarachnoid hemorrhage--especially clinical and pharmacological effect of Ca++ antagonist for vasospasm].
Topics: Animals; Calcium Channel Blockers; Cattle; Cerebrovascular Circulation; Diltiazem; Humans; Ischemic | 1993 |
Are the calcium antagonists really useful in cerebral aneurysmal surgery? A retrospective study.
Topics: Activities of Daily Living; Adult; Aged; Brain Ischemia; Calcium Channel Blockers; Cerebral Angiogra | 1994 |
The role of early Ca2+ influx in the pathogenesis of delayed neuronal death after brief forebrain ischemia in gerbils.
Topics: Animals; Autoradiography; Brain; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cell Deat | 1993 |
[High dose nicardipine therapy for delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage].
Topics: Adult; Aged; Cerebral Angiography; Constriction; Female; Humans; Ischemic Attack, Transient; Male; M | 1993 |
The role of active smooth-muscle contraction in the occurrence of chronic vasospasm in the canine two-hemorrhage model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Dogs; Female; Ischemic Attac | 1994 |
Protection by nicorandil against the dysfunction of the central vagal baroreflex system following transient global cerebral ischaemia in dogs.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cerebrovascular Circulation; Dogs; Female; Heart Rate; Isc | 1993 |
Experimental basilar artery spasm caused by autologous blood application: effects of clot removal and topical nicardipine.
Topics: Animals; Basilar Artery; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Hydrogen-Ion Concen | 1993 |
Intra-arterial infusion of papaverine combined with intravenous administration of high-dose nicardipine for cerebral vasospasm.
Topics: Adult; Aged; Aneurysm, Ruptured; Calcium Channel Blockers; Cerebral Angiography; Dose-Response Relat | 1995 |
Nicardipine and MK-801 attenuate platelet-activating factor increases following cerebral ischemia-reperfusion in gerbils.
Topics: Analysis of Variance; Animals; Body Temperature; Brain; Cerebral Cortex; Dizocilpine Maleate; Female | 1996 |
[Effects of lacidipine, a new dihydropyridipine derivative, on various cerebral ischemia models].
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Circulation; Dihydropyridines; Di | 1996 |
Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model.
Topics: Animals; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; Ischemic Attack, | 1997 |
Effects of a calcium antagonist, lacidipine, on experimental focal cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Brain; Calcium Channel Blockers; Cerebral Arterial Diseases; Cerebr | 1997 |
[Efficacy of nicardipine prolonged-release pellet on cerebral vasospasm in dogs].
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Dogs; Infusion Pumps, Implantable; Isc | 1998 |
Effect of nicardipine, a Ca2+ channel blocker, on pyruvate dehydrogenase activity and energy metabolites during cerebral ischemia and reperfusion in gerbil brain.
Topics: Animals; Calcium Channel Blockers; Energy Metabolism; Gerbillinae; Ischemic Attack, Transient; Male; | 1998 |
Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury.
Topics: Animals; Body Temperature; Brain Edema; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Prote | 1999 |
Effect of nicardipine on basilar artery vasoactive responses after subarachnoid hemorrhage.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Basilar Artery; Blood Pressure; Dose-Response Relati | 1992 |
Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty, Balloon; Female; Humans; Infusions, | 1992 |
Comparison of the anticonstrictor action of dihydropyridines (nimodipine and nicardipine) and Mg2+ in isolated human cerebral arteries.
Topics: Adult; Aged; Aged, 80 and over; Calcium; Cerebral Arteries; Dinoprost; Female; Humans; In Vitro Tech | 1992 |
Systemic vasomotor interaction between nicardipine and hypocapnic alkalosis in man.
Topics: Aged; Alkalosis, Respiratory; Blood Gas Analysis; Dose-Response Relationship, Drug; Evaluation Studi | 1992 |
[Cerebral vasospasm after subarachnoid hemorrhage, and inhibitory effect of nicardipine investigated by means of transcranial Doppler ultrasonography].
Topics: Adult; Aged; Blood Flow Velocity; Cerebrovascular Circulation; Echoencephalography; Female; Humans; | 1991 |
[Ca++ antagonist and acute brain ischemia: effects of nilvadipine and nicardipine on middle cerebral artery occlusion in rats].
Topics: Acute Disease; Animals; Calcium Channel Blockers; Cerebral Infarction; Constriction; Ischemic Attack | 1991 |
Effects of nicardipine treatment on Na(+)-K+ ATPase and lipid peroxidation after experimental subarachnoid haemorrhage.
Topics: Animals; Brain; Ischemic Attack, Transient; Lipid Peroxidation; Lipid Peroxides; Male; Nicardipine; | 1991 |
The effect of nicardipine on vasospasm in rabbit basilar artery after subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Blood Pressure; Injections, Intravenous; Injections, Intraventricular; Isch | 1991 |
Activation of the protein kinase C-mediated contractile system in canine basilar artery undergoing chronic vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Chronic Disease; Dinoprost; | 1991 |
Prevention by nicardipine of dog basilar artery spasm caused by oxyhemoglobin in vivo and in vitro.
Topics: Animals; Basilar Artery; Dogs; In Vitro Techniques; Ischemic Attack, Transient; Nicardipine; Oxyhemo | 1991 |
Effect of endothelin on the canine basilar artery.
Topics: Animals; Basilar Artery; Blood Pressure; Cattle; Dose-Response Relationship, Drug; Endothelins; Fema | 1990 |
[Cerebral hemodynamics of post-ischemic delayed hypoperfusion (PDH) and the effects of nicardipine on the PDH].
Topics: Animals; Cerebrovascular Circulation; Dogs; Ischemic Attack, Transient; Nicardipine; Stimulation, Ch | 1990 |
Calcium-calmodulin binding in ischemic rat neurons after calcium channel blocker therapy.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Calmodulin; Ischemic Attack, Transient; Nicardipi | 1990 |
Nicardipine HCl: clinical experience in patients undergoing anaesthesia for intracranial aneurysm clipping.
Topics: Adult; Anesthesia, Inhalation; Female; Hemodynamics; Humans; Intracranial Aneurysm; Ischemic Attack, | 1989 |
[Role of stopping calcium inhibitors in the worsening of postoperative vasospasm during the treatment of intracranial aneurysm].
Topics: Adult; Brain Edema; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Middle | 1989 |
The potential use of nicardipine in cerebrovascular disease.
Topics: Animals; Body Water; Brain; Brain Ischemia; Calcium; Humans; Ischemic Attack, Transient; Nicardipine | 1989 |
Baroreflex sensitivity alteration following transient hemispheric ischaemia in rats: protective effect of alphamethyldopa and guanfacine.
Topics: Animals; Blood Pressure; Enalapril; Guanfacine; Guanidines; Heart Rate; Ischemic Attack, Transient; | 1986 |
Dose-escalation study of intravenous nicardipine in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Female; Humans; Infusions, Intravenous; Intracranial Aneurysm; Ischemic Attack, Transie | 1988 |
[The effects of ticlopidine and nicardipine on the prevention of symptomatic vasospasm after aneurysmal rupture].
Topics: Adult; Aged; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Middle Aged; N | 1988 |
The potential beneficial effect of nicardipine in a rat model of transient forebrain ischemia.
Topics: Animals; Disease Models, Animal; Ischemic Attack, Transient; Male; Nicardipine; Rats; Rats, Inbred S | 1987 |
Effect of cisternal administration of nicardipine hydrochloride on cerebral vasospasm--a preliminary report.
Topics: Adult; Cisterna Magna; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Nicardipine; V | 1987 |
Mechanism of action of a novel antivasospasm drug, HA1077.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium Chloride; | 1987 |
[Influence of a calcium inhibitor on the neurologic development after meningeal hemorrhage caused by aneurysm rupture].
Topics: Adult; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; M | 1987 |
[Hemodynamic carotid effects of the administration of nicardipine during the early phase of meningeal hemorrhage].
Topics: Adult; Carotid Arteries; Cerebrovascular Circulation; Hemodynamics; Humans; Injections, Intra-Arteri | 1987 |