nicardipine has been researched along with Intracranial Aneurysm in 48 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the effect of nicardipine prolonged-release implants (NPRIs) on cerebral vasospasm and clinical outcome after severe subarachnoid hemorrhage." | 9.12 | Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study. ( Barth, M; Capelle, HH; Kasuya, H; Luecke, T; Münch, E; Schmiedek, P; Thomé, C; Vajkoczy, P; Weidauer, S; Weiss, C, 2007) |
| "High-dose intravenous nicardipine has been shown to reduce the incidence of angiographic and symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (SAH), but treatment may be complicated by side effects, including hypotension or pulmonary edema/azotemia." | 9.07 | A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study. ( Germanson, TP; Haley, EC; Kassell, NF; Torner, JC; Truskowski, LL, 1994) |
| "We present a case of diltiazem intoxication resulting in repeated asystole after the induction of anesthesia." | 7.78 | [Suspected diltiazem intoxication resulting in repeated asystole after the induction of anesthesia]. ( Hara, T; Harioka, T; Ishiyama, T; Kimura, Y; Matsukawa, T; Nakasato, A; Okamura, M, 2012) |
| "BRIEF SUMMARY: We describe the use of adenosine-induced cardiac arrest to facilitate intracranial aneurysm clip ligation." | 7.77 | Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. ( Borel, CO; Britz, GW; Guinn, NR; Lam, AM; McDonagh, DL; Powers, CJ; Warner, DS; Wright, DR; Zomorodi, AR, 2011) |
| "To evaluate the efficacy, tolerability, and safety of nicardipine infusion in controlling the elevated blood pressure after subarachnoid hemorrhage (SAH)." | 7.76 | Nicardipine infusion for blood pressure control in patients with subarachnoid hemorrhage. ( Abdelhak, T; Hacein-Bey, L; Mitsias, P; Schultz, L; Shah, I; Varelas, PN; Wellwood, J, 2010) |
| "Seven patients scheduled for clipping of an aneurysm of the internal carotid artery after subarachnoid haemorrhage, were studied in order to evaluate the efficacy of a bolus injection of nicardipine (2 mg) in the treatment of intra-operative hypertension on the blood flow velocity of vessel near the aneurysm under isoflurane anaesthesia." | 7.68 | Effect of nicardipine on the blood flow velocity in the vessel near a cerebral aneurysm of the internal carotid artery during cerebral aneurysm surgery: its therapeutic use for intra-operative hypertension. ( Abe, K; Inagaki, Y; Iwanaga, H, 1993) |
| "This report describes the successful treatment of cerebral vasospasm after subarachnoid hemorrhage with superselective intra-arterial infusion of papaverine hydrochloride." | 7.68 | Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. ( Kaku, Y; Kazekawa, K; Tsukahara, T; Yonekawa, Y, 1992) |
| "A dose-escalation study of the calcium ion entry blocking drug nicardipine was performed using large dose infusions in 67 patients with recent aneurysmal subarachnoid hemorrhage (SAH)." | 7.67 | Dose-escalation study of intravenous nicardipine in patients with aneurysmal subarachnoid hemorrhage. ( Adams, HP; Beck, DW; Biller, J; Boarini, DJ; Flamm, ES; Godersky, JC; Loftus, CM; Marler, JR; Pinto, RS; Walker, MD, 1988) |
| " During anaesthesia for intracranial aneurysm surgery, we prospectively compared haemodynamic values obtained from 13 patients being treated with nicardipine HCl (0." | 7.67 | Nicardipine HCl: clinical experience in patients undergoing anaesthesia for intracranial aneurysm clipping. ( Adams, HP; Godersky, JC; Maktabi, M; Sokoll, MD; Warner, DS, 1989) |
| "Hypotension was the main side effect, and it occurred only in the two groups that received the highest doses." | 6.67 | Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study. ( Bourdeix, I; Chaumet-Riffaud, P; Massiou, H, 1992) |
| "Vasospasm following subarachnoid hemorrhage (SAH) remains difficult to prevent despite extensive investigative efforts." | 5.34 | Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients. ( Hori, T; Kasuya, H; Krischek, B; Onda, H, 2007) |
| " Fifteen of 42 patients were treated with the lower dosage levels of nicardipine (0." | 5.27 | Combination of aminocaproic acid and nicardipine in treatment of aneurysmal subarachnoid hemorrhage. ( Adams, HP; Beck, DW; Flamm, ES; Godersky, JC; Loftus, CM, 1988) |
| "The purpose of this study was to investigate the effect of nicardipine prolonged-release implants (NPRIs) on cerebral vasospasm and clinical outcome after severe subarachnoid hemorrhage." | 5.12 | Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study. ( Barth, M; Capelle, HH; Kasuya, H; Luecke, T; Münch, E; Schmiedek, P; Thomé, C; Vajkoczy, P; Weidauer, S; Weiss, C, 2007) |
| "A study of medical complications observed in the placebo limb of a large, randomized, controlled trial of the calcium antagonist, nicardipine, after subarachnoid hemorrhage." | 5.08 | Medical complications of aneurysmal subarachnoid hemorrhage: a report of the multicenter, cooperative aneurysm study. Participants of the Multicenter Cooperative Aneurysm Study. ( Germanson, T; Haley, EC; Kassell, NF; Kongable, G; Solenski, NJ; Torner, JC; Truskowski, L, 1995) |
| "High-dose intravenous nicardipine has been shown to reduce the incidence of angiographic and symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (SAH), but treatment may be complicated by side effects, including hypotension or pulmonary edema/azotemia." | 5.07 | A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study. ( Germanson, TP; Haley, EC; Kassell, NF; Torner, JC; Truskowski, LL, 1994) |
| "OBJECTIVE Intravenous nicardipine is commonly used for blood pressure reduction in patients with acute stroke." | 3.88 | Paradoxical cerebrovascular hemodynamic changes with nicardipine. ( Lahiri, S; Lyden, PD; Mayer, SA; Nezhad, M; Rinsky, B; Rosengart, A; Schlick, KH, 2018) |
| "We present a case of diltiazem intoxication resulting in repeated asystole after the induction of anesthesia." | 3.78 | [Suspected diltiazem intoxication resulting in repeated asystole after the induction of anesthesia]. ( Hara, T; Harioka, T; Ishiyama, T; Kimura, Y; Matsukawa, T; Nakasato, A; Okamura, M, 2012) |
| "BRIEF SUMMARY: We describe the use of adenosine-induced cardiac arrest to facilitate intracranial aneurysm clip ligation." | 3.77 | Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. ( Borel, CO; Britz, GW; Guinn, NR; Lam, AM; McDonagh, DL; Powers, CJ; Warner, DS; Wright, DR; Zomorodi, AR, 2011) |
| "We conducted a single-center, retrospective review of consecutive patients with clinically symptomatic vasospasm after aneurysmal subarachnoid hemorrhage that failed medical management with "triple H therapy" and subsequently received intraarterial nicardipine and/or milrinone between March 2005 and July 2007." | 3.76 | Hemodynamic management and outcome of patients treated for cerebral vasospasm with intraarterial nicardipine and/or milrinone. ( Bittner, E; Marota, JJ; Pivi, S; Schmidt, U, 2010) |
| "To evaluate the efficacy, tolerability, and safety of nicardipine infusion in controlling the elevated blood pressure after subarachnoid hemorrhage (SAH)." | 3.76 | Nicardipine infusion for blood pressure control in patients with subarachnoid hemorrhage. ( Abdelhak, T; Hacein-Bey, L; Mitsias, P; Schultz, L; Shah, I; Varelas, PN; Wellwood, J, 2010) |
| "Seven patients scheduled for clipping of an aneurysm of the internal carotid artery after subarachnoid haemorrhage, were studied in order to evaluate the efficacy of a bolus injection of nicardipine (2 mg) in the treatment of intra-operative hypertension on the blood flow velocity of vessel near the aneurysm under isoflurane anaesthesia." | 3.68 | Effect of nicardipine on the blood flow velocity in the vessel near a cerebral aneurysm of the internal carotid artery during cerebral aneurysm surgery: its therapeutic use for intra-operative hypertension. ( Abe, K; Inagaki, Y; Iwanaga, H, 1993) |
| "This report describes the successful treatment of cerebral vasospasm after subarachnoid hemorrhage with superselective intra-arterial infusion of papaverine hydrochloride." | 3.68 | Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. ( Kaku, Y; Kazekawa, K; Tsukahara, T; Yonekawa, Y, 1992) |
| "We examined the efficacy of slow-release, and prolonged diffusion silicone pellets mixed with papaverine hydrochloride in the treatment of cerebral vasospasms following subarachnoid hemorrhage." | 3.67 | [Sustained-release pellet of vasodilators--basic experiment]. ( Arimitsu, T; Mori, K; Oda, Y; Okumura, T, 1984) |
| " During anaesthesia for intracranial aneurysm surgery, we prospectively compared haemodynamic values obtained from 13 patients being treated with nicardipine HCl (0." | 3.67 | Nicardipine HCl: clinical experience in patients undergoing anaesthesia for intracranial aneurysm clipping. ( Adams, HP; Godersky, JC; Maktabi, M; Sokoll, MD; Warner, DS, 1989) |
| "A dose-escalation study of the calcium ion entry blocking drug nicardipine was performed using large dose infusions in 67 patients with recent aneurysmal subarachnoid hemorrhage (SAH)." | 3.67 | Dose-escalation study of intravenous nicardipine in patients with aneurysmal subarachnoid hemorrhage. ( Adams, HP; Beck, DW; Biller, J; Boarini, DJ; Flamm, ES; Godersky, JC; Loftus, CM; Marler, JR; Pinto, RS; Walker, MD, 1988) |
| "Hypotension was the main side effect, and it occurred only in the two groups that received the highest doses." | 2.67 | Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study. ( Bourdeix, I; Chaumet-Riffaud, P; Massiou, H, 1992) |
| "Outcome of patients with aneurysmal subarachnoid hemorrhage (SAH) has improved over the last decades." | 2.49 | SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials. ( Cusimano, MD; Etminan, N; Hanggi, D; Hasan, D; Ilodigwe, D; Jaja, B; Lantigua, H; Le Roux, P; Lo, B; Louffat-Olivares, A; Macdonald, RL; Mayer, S; Molyneux, A; Quinn, A; Schenk, T; Schweizer, TA; Singh, J; Spears, J; Todd, M; Torner, J; Vergouwen, MD; Wong, GK, 2013) |
| "In the case of hypertensive encephalopathy, the lowering of blood pressure is therapeutic as well as diagnostic." | 2.43 | [Antihypertensive management in acute cerebral stroke]. ( Ziliene, V, 2005) |
| "Meningitis was clinically diagnosed from the blood samplings and cerebrospinal fluid (CSF) examinations." | 1.42 | Risk factors for meningitis after craniotomy in patients with subarachnoid hemorrhage due to anterior circulation aneurysms rupture. ( Endo, H; Fujimura, M; Inoue, T; Niizuma, K; Sakata, H; Sato, K; Shimizu, H; Tominaga, T, 2015) |
| "Vasospasm following subarachnoid hemorrhage (SAH) remains difficult to prevent despite extensive investigative efforts." | 1.34 | Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients. ( Hori, T; Kasuya, H; Krischek, B; Onda, H, 2007) |
| "As soon as the subarachnoid hemorrhage diagnosis is confirmed by computed tomography (or if unconfirmed, by lumbar puncture), we assume that each patient may have an aneurysm." | 1.29 | Are the calcium antagonists really useful in cerebral aneurysmal surgery? A retrospective study. ( Alhayek, G; Fournier, D; Guy, G; Menei, P; Mercier, P; Rizk, T, 1994) |
| "Nicardipine was infused until the mean arterial blood pressure decreased to about 75% of the initial value and was maintained at this level until the completion of aneurysm clipping." | 1.29 | The effect of nicardipine on carotid blood flow velocity, local cerebral blood flow, and carbon dioxide reactivity during cerebral aneurysm surgery. ( Abe, K; Iwanaga, H; Shimada, Y; Yoshiya, I, 1993) |
| " Fifteen of 42 patients were treated with the lower dosage levels of nicardipine (0." | 1.27 | Combination of aminocaproic acid and nicardipine in treatment of aneurysmal subarachnoid hemorrhage. ( Adams, HP; Beck, DW; Flamm, ES; Godersky, JC; Loftus, CM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (25.00) | 18.7374 |
| 1990's | 22 (45.83) | 18.2507 |
| 2000's | 7 (14.58) | 29.6817 |
| 2010's | 7 (14.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lahiri, S | 1 |
| Nezhad, M | 1 |
| Schlick, KH | 1 |
| Rinsky, B | 1 |
| Rosengart, A | 1 |
| Mayer, SA | 2 |
| Lyden, PD | 1 |
| Macdonald, RL | 1 |
| Jaja, B | 1 |
| Cusimano, MD | 1 |
| Etminan, N | 1 |
| Hanggi, D | 1 |
| Hasan, D | 1 |
| Ilodigwe, D | 1 |
| Lantigua, H | 1 |
| Le Roux, P | 1 |
| Lo, B | 1 |
| Louffat-Olivares, A | 1 |
| Mayer, S | 1 |
| Molyneux, A | 1 |
| Quinn, A | 1 |
| Schweizer, TA | 1 |
| Schenk, T | 1 |
| Spears, J | 1 |
| Todd, M | 1 |
| Torner, J | 1 |
| Vergouwen, MD | 1 |
| Wong, GK | 1 |
| Singh, J | 1 |
| Inoue, T | 1 |
| Shimizu, H | 1 |
| Fujimura, M | 1 |
| Sato, K | 1 |
| Endo, H | 1 |
| Niizuma, K | 1 |
| Sakata, H | 1 |
| Tominaga, T | 1 |
| Hashimoto, M | 1 |
| Johkura, K | 1 |
| Ichikawa, T | 1 |
| Kojima, A | 1 |
| Nishimura, S | 1 |
| Shinonaga, M | 1 |
| Schmidt, U | 1 |
| Bittner, E | 1 |
| Pivi, S | 1 |
| Marota, JJ | 1 |
| Varelas, PN | 1 |
| Abdelhak, T | 1 |
| Wellwood, J | 1 |
| Shah, I | 1 |
| Hacein-Bey, L | 1 |
| Schultz, L | 1 |
| Mitsias, P | 1 |
| Guinn, NR | 1 |
| McDonagh, DL | 1 |
| Borel, CO | 1 |
| Wright, DR | 1 |
| Zomorodi, AR | 1 |
| Powers, CJ | 1 |
| Warner, DS | 2 |
| Lam, AM | 1 |
| Britz, GW | 1 |
| Kimura, Y | 1 |
| Okamura, M | 1 |
| Harioka, T | 1 |
| Hara, T | 1 |
| Nakasato, A | 1 |
| Ishiyama, T | 1 |
| Matsukawa, T | 1 |
| Ziliene, V | 1 |
| Barth, M | 1 |
| Capelle, HH | 1 |
| Weidauer, S | 1 |
| Weiss, C | 1 |
| Münch, E | 1 |
| Thomé, C | 1 |
| Luecke, T | 1 |
| Schmiedek, P | 1 |
| Kasuya, H | 2 |
| Vajkoczy, P | 1 |
| Krischek, B | 1 |
| Onda, H | 1 |
| Hori, T | 1 |
| Abdennour, L | 1 |
| Lejean, L | 1 |
| Bonneville, F | 1 |
| Boch, AL | 1 |
| Puybasset, L | 1 |
| Mocco, J | 1 |
| Rose, JC | 1 |
| Komotar, RJ | 1 |
| Aoyagi, N | 1 |
| Okumura, T | 1 |
| Oda, Y | 1 |
| Arimitsu, T | 1 |
| Mori, K | 1 |
| Handa, J | 1 |
| Matsuda, M | 2 |
| Nakasu, Y | 1 |
| Nakasu, S | 1 |
| Kidooka, M | 1 |
| Watanabe, K | 1 |
| Kataoka, K | 1 |
| Niiyama, K | 1 |
| Uejima, T | 1 |
| Kuroda, R | 1 |
| Ioku, M | 1 |
| Yamada, K | 1 |
| Taneda, M | 1 |
| Hayakawa, T | 1 |
| Shibuya, M | 1 |
| Suzuki, Y | 1 |
| Enomoto, H | 1 |
| Okada, T | 1 |
| Ogura, K | 1 |
| Sugita, K | 1 |
| Solenski, NJ | 1 |
| Haley, EC | 3 |
| Kassell, NF | 5 |
| Kongable, G | 1 |
| Germanson, T | 2 |
| Truskowski, L | 2 |
| Torner, JC | 4 |
| Hanley, DF | 1 |
| Ulatowski, JA | 1 |
| Golfinos, JG | 1 |
| Thompson, BG | 1 |
| Zabramski, JM | 1 |
| Spetzler, RF | 1 |
| Kitano, H | 1 |
| Weir, B | 1 |
| MacDonald, L | 1 |
| Saito, I | 1 |
| Mercier, P | 1 |
| Alhayek, G | 1 |
| Rizk, T | 1 |
| Fournier, D | 1 |
| Menei, P | 1 |
| Guy, G | 1 |
| Truskowski, LL | 1 |
| Germanson, TP | 2 |
| Lanzino, G | 2 |
| Alves, W | 1 |
| Abe, K | 3 |
| Demizu, A | 1 |
| Imanishi, M | 1 |
| Iwanaga, H | 3 |
| Inagaki, Y | 1 |
| Shimada, Y | 1 |
| Yoshiya, I | 1 |
| Yoshimura, S | 1 |
| Tsukahara, T | 2 |
| Hashimoto, N | 1 |
| Kazekawa, K | 2 |
| Kobayashi, A | 1 |
| Kongable, GL | 1 |
| Kaku, Y | 1 |
| Yonekawa, Y | 1 |
| Combes, P | 1 |
| Fauvage, B | 1 |
| Massiou, H | 1 |
| Chaumet-Riffaud, P | 1 |
| Bourdeix, I | 1 |
| Ikeda, K | 1 |
| Minami, Y | 1 |
| Yoshimatsu, N | 1 |
| Fujita, R | 1 |
| Ikeda, T | 1 |
| Isshiki, A | 1 |
| Adams, HP | 5 |
| Sokoll, MD | 1 |
| Maktabi, M | 1 |
| Godersky, JC | 4 |
| Homs, JB | 2 |
| Szekely, B | 1 |
| Abhay, K | 1 |
| Melon, E | 3 |
| Lepresle, E | 2 |
| Keravel, Y | 1 |
| Bonnet, F | 1 |
| Montarry, M | 1 |
| Chacornac, R | 1 |
| Philippon, B | 1 |
| Bouchet, C | 1 |
| Guichard, P | 1 |
| Picard-Claret, M | 1 |
| Abhay, KP | 1 |
| Nguyen, JP | 2 |
| Gaston, A | 1 |
| Biller, J | 2 |
| Beck, DW | 2 |
| Flamm, ES | 2 |
| Loftus, CM | 2 |
| Pinto, RS | 1 |
| Marler, JR | 1 |
| Walker, MD | 1 |
| Boarini, DJ | 1 |
| Fukusaki, M | 1 |
| Shimada, M | 1 |
| Shibata, O | 1 |
| Haseba, S | 1 |
| Gotoh, Y | 1 |
| Fujita, K | 1 |
| Yamashita, H | 1 |
| Masumura, M | 1 |
| Ehara, K | 1 |
| Tamaki, N | 1 |
| Matsumoto, S | 1 |
| Rostaing, S | 1 |
| Février, MJ | 1 |
| Wilmart, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Treatment of Subarachnoid Hemorrhage With Human Albumin[NCT00283400] | 47 participants (Actual) | Interventional | 2006-01-31 | Terminated (stopped due to Study met safety endpoints) | |||
| Efficacy and Safety of Cilostazol-Nimodipine Combined Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage (aSAH): A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial[NCT04148105] | Phase 4 | 120 participants (Anticipated) | Interventional | 2019-11-01 | Recruiting | ||
| The Intra-arterial Vasospasm Trial(iVAST)- A Multi-center Randomized Study[NCT01996436] | Phase 4 | 330 participants (Anticipated) | Interventional | 2016-08-29 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of subjects with good clinical outcome defined as a Glasgw Outcome Scale score of 0-1 (NCT00283400)
Timeframe: 3 months after enrollment
| Intervention | participants (Number) |
|---|---|
| Dosage Tier 1 | 13 |
| Dosage Tier 2 | 17 |
| Dosage Tier 3 | 3 |
Tolerability outcome: Subject's ability to receive the full allocated human albumin dose without incurring frank congestive heart failure or experiencing anaphylactic reactions that required discontinuation of the treatment. Study would be terminated if 2 or more subjects developed severe or life-threatening heart failure considered to be related (probably, possibly, and definitely) to albumin treatment. (NCT00283400)
Timeframe: 9 days after enrollment
| Intervention | participants (Number) |
|---|---|
| Dosage Tier 1 | 0 |
| Dosage Tier 2 | 1 |
| Dosage Tier 3 | 2 |
"Serious adverse events included neurological and medical complications and neurological deterioration.~Neurological deterioration was defined as a decline by more than 2 points in the Glasgow Coma Scale." (NCT00283400)
Timeframe: within 3 months after enrollment
| Intervention | participants (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Symptomatic Cerebral Vasospasm | Pulmonary Edema | ARDS | Rebleeding | Pulmonary Embolism | Gram-Negative Ventriculitis | Hypotension due to sepsis | |
| Dosage Tier 1 | 4 | 2 | 0 | 1 | 1 | 1 | 1 |
| Dosage Tier 2 | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| Dosage Tier 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 |
5 reviews available for nicardipine and Intracranial Aneurysm
| Article | Year |
|---|---|
SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials.
Topics: Antioxidants; Brain Infarction; Calcium Channel Blockers; Critical Care; Dioxanes; Drug Therapy, Com | 2013 |
[Antihypertensive management in acute cerebral stroke].
Topics: Acute Disease; Adult; Antihypertensive Agents; Brain Injuries; Cerebrovascular Circulation; Emergenc | 2005 |
Blood pressure management in patients with intracerebral and subarachnoid hemorrhage.
Topics: Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Blood Volume; Brain; Brain Ischemia; E | 2006 |
Cerebral vasospasm.
Topics: Aneurysm, Ruptured; Blood Pressure; Blood Volume; Brain Ischemia; Catheterization; Cerebral Infarcti | 1993 |
Calcium antagonists in the management of patients with aneurysmal subarachnoid hemorrhage: a review.
Topics: Calcium Channel Blockers; Cerebral Infarction; Humans; Intracranial Aneurysm; Ischemic Attack, Trans | 1990 |
9 trials available for nicardipine and Intracranial Aneurysm
| Article | Year |
|---|---|
Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study.
Topics: Adult; Delayed-Action Preparations; Double-Blind Method; Drug Implants; Female; Humans; Intracranial | 2007 |
Effects of prophylactic intrathecal administrations of nicardipine on vasospasm in patients with severe aneurysmal subarachnoid haemorrhage.
Topics: Adult; Aged; Aneurysm, Ruptured; Basilar Artery; Cerebral Angiography; Female; Humans; Injections, S | 1994 |
Medical complications of aneurysmal subarachnoid hemorrhage: a report of the multicenter, cooperative aneurysm study. Participants of the Multicenter Cooperative Aneurysm Study.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Cause of Death; Critical Care; Double-Blind Meth | 1995 |
A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; | 1994 |
Plasma glucose levels and outcome after aneurysmal subarachnoid hemorrhage.
Topics: Adult; Blood Glucose; Glasgow Coma Scale; Humans; Intracranial Aneurysm; Middle Aged; Multivariate A | 1993 |
A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Incidence; Infusions, Intravenous; I | 1993 |
A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Incidence; Infusions, Intravenous; I | 1993 |
A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Incidence; Infusions, Intravenous; I | 1993 |
A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
Topics: Adult; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Incidence; Infusions, Intravenous; I | 1993 |
Risk classification after aneurysmal subarachnoid hemorrhage.
Topics: Calcium Channel Blockers; Female; Humans; Infusions, Intravenous; Intracranial Aneurysm; Logistic Mo | 1998 |
Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study.
Topics: Administration, Oral; Adult; Aged; Chi-Square Distribution; Female; Humans; Hypotension; Infusions, | 1992 |
Calcium antagonists in the management of patients with aneurysmal subarachnoid hemorrhage: a review.
Topics: Calcium Channel Blockers; Cerebral Infarction; Humans; Intracranial Aneurysm; Ischemic Attack, Trans | 1990 |
35 other studies available for nicardipine and Intracranial Aneurysm
| Article | Year |
|---|---|
Paradoxical cerebrovascular hemodynamic changes with nicardipine.
Topics: Administration, Intravenous; Adult; Aged; Aneurysm, Ruptured; Blood Flow Velocity; Calcium Channel B | 2018 |
Risk factors for meningitis after craniotomy in patients with subarachnoid hemorrhage due to anterior circulation aneurysms rupture.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angiography, Digital Subtraction; Antibiotic Pro | 2015 |
Conservative treatment of ruptured vertebrobasilar dissecting aneurysm.
Topics: Adjuvants, Anesthesia; Aged; Aged, 80 and over; Antihypertensive Agents; Basilar Artery; Bed Rest; B | 2008 |
Hemodynamic management and outcome of patients treated for cerebral vasospasm with intraarterial nicardipine and/or milrinone.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Drug Therapy, Combination; | 2010 |
Nicardipine infusion for blood pressure control in patients with subarachnoid hemorrhage.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Diastole; Female; Glasgow Coma Scale; Homeostasis; Hu | 2010 |
Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review.
Topics: Adenosine; Aged; Anesthesia, General; Antihypertensive Agents; Cardiovascular Agents; Dose-Response | 2011 |
[Suspected diltiazem intoxication resulting in repeated asystole after the induction of anesthesia].
Topics: Adult; Anesthesia; Diltiazem; Drug Interactions; Embolization, Therapeutic; Heart Arrest; Humans; In | 2012 |
Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients.
Topics: Aged; Aneurysm, Ruptured; Drug Implants; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; M | 2007 |
[Endovascular treatment of vasospasm following subarachnoid aneurysmal haemorrhage].
Topics: Calcium Channel Blockers; Humans; Intracranial Aneurysm; Nicardipine; Nimodipine; Nitroprusside; Pap | 2007 |
Late vasospasm is very difficult to control, since it is caused by strong chemical reaction to the smooth muscle.
Topics: Humans; Intracranial Aneurysm; Muscle, Smooth, Vascular; Nicardipine; Vasodilator Agents; Vasospasm, | 2008 |
[Sustained-release pellet of vasodilators--basic experiment].
Topics: Delayed-Action Preparations; Diltiazem; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; N | 1984 |
Early operation of aneurysmal subarachnoid hemorrhage--use of nicardipine, a calcium channel blocker.
Topics: Adult; Aged; Calcium Channel Blockers; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Nic | 1984 |
Treatment of severe localized cerebral vasospasm following recurrent hemorrhage from middle cerebral artery aneurysm--case report.
Topics: Brain; Cerebral Angiography; Cerebral Arteries; Female; Humans; Intracranial Aneurysm; Ischemic Atta | 1993 |
Medical management of aneurysmal subarachnoid hemorrhage.
Topics: Combined Modality Therapy; Critical Care; Humans; Intracranial Aneurysm; Multicenter Studies as Topi | 1995 |
Are the calcium antagonists really useful in cerebral aneurysmal surgery? A retrospective study.
Topics: Brain Ischemia; Calcium Channel Blockers; Humans; Intracranial Aneurysm; Neuropsychological Tests; N | 1994 |
[Effect of high dose nicardipine in patients with ruptured cerebral aneurysm].
Topics: Adult; Aged; Aneurysm, Ruptured; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; | 1993 |
[Controversies in the surgical treatment of subarachnoid hemorrhage with special reference to the prognosis of patients].
Topics: Adult; Age Factors; Aged; Aneurysm, Ruptured; Female; Humans; Intracranial Aneurysm; Male; Middle Ag | 1993 |
Are the calcium antagonists really useful in cerebral aneurysmal surgery? A retrospective study.
Topics: Activities of Daily Living; Adult; Aged; Brain Ischemia; Calcium Channel Blockers; Cerebral Angiogra | 1994 |
[The effect of nicardipine on internal carotid artery blood flow velocity, local cerebral blood flow and carbon dioxide reactivity].
Topics: Adult; Aged; Blood Flow Velocity; Carbon Dioxide; Carotid Artery, Internal; Cerebrovascular Circulat | 1993 |
Effect of nicardipine on the blood flow velocity in the vessel near a cerebral aneurysm of the internal carotid artery during cerebral aneurysm surgery: its therapeutic use for intra-operative hypertension.
Topics: Blood Flow Velocity; Brain; Carotid Artery Diseases; Carotid Artery, Internal; Humans; Hypertension; | 1993 |
The effect of nicardipine on carotid blood flow velocity, local cerebral blood flow, and carbon dioxide reactivity during cerebral aneurysm surgery.
Topics: Adult; Aged; Blood Flow Velocity; Carbon Dioxide; Carotid Artery, Internal; Cerebrovascular Circulat | 1993 |
Intra-arterial infusion of papaverine combined with intravenous administration of high-dose nicardipine for cerebral vasospasm.
Topics: Adult; Aged; Aneurysm, Ruptured; Calcium Channel Blockers; Cerebral Angiography; Dose-Response Relat | 1995 |
Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty, Balloon; Female; Humans; Infusions, | 1992 |
Systemic vasomotor interaction between nicardipine and hypocapnic alkalosis in man.
Topics: Aged; Alkalosis, Respiratory; Blood Gas Analysis; Dose-Response Relationship, Drug; Evaluation Studi | 1992 |
[A comparison of induced hypotensive anesthesia using trimetaphan, prostaglandin E1 and nicardipine for neurosurgery].
Topics: Alprostadil; Female; Humans; Hypotension, Controlled; Intracranial Aneurysm; Male; Middle Aged; Nica | 1991 |
Nicardipine HCl: clinical experience in patients undergoing anaesthesia for intracranial aneurysm clipping.
Topics: Adult; Anesthesia, Inhalation; Female; Hemodynamics; Humans; Intracranial Aneurysm; Ischemic Attack, | 1989 |
[Controlled hypotension using nitroprusside in surgery of intracranial aneurysm. Effect of preoperative treatment with calcium inhibitor].
Topics: Adult; Anesthesia, General; Female; Ferricyanides; Humans; Hypotension, Controlled; Intracranial Ane | 1989 |
[Effects of an intravenous injection of nicardipine on cerebral blood flow in subarachnoid hemorrhage caused by intracranial aneurysm].
Topics: Adult; Aged; Blood Pressure; Cerebrovascular Circulation; Female; Humans; Injections, Intravenous; I | 1989 |
[Role of stopping calcium inhibitors in the worsening of postoperative vasospasm during the treatment of intracranial aneurysm].
Topics: Adult; Brain Edema; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Middle | 1989 |
Management of aneurysmal subarachnoid hemorrhage.
Topics: Aminocaproic Acid; Humans; Intracranial Aneurysm; Nervous System Diseases; Nicardipine; Nimodipine; | 1988 |
Combination of aminocaproic acid and nicardipine in treatment of aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Aminocaproates; Drug Therapy, Combination; Female; Humans; Intracranial Aneurysm; Male; | 1988 |
Dose-escalation study of intravenous nicardipine in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Female; Humans; Infusions, Intravenous; Intracranial Aneurysm; Ischemic Attack, Transie | 1988 |
[Hemodynamics during induced hypotension with continuous administration of nicardipine and enflurane].
Topics: Enflurane; Female; Hemodynamics; Humans; Hypotension, Controlled; Injections, Intravenous; Intracran | 1988 |
[The effects of ticlopidine and nicardipine on the prevention of symptomatic vasospasm after aneurysmal rupture].
Topics: Adult; Aged; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Middle Aged; N | 1988 |
[Influence of a calcium inhibitor on the neurologic development after meningeal hemorrhage caused by aneurysm rupture].
Topics: Adult; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; M | 1987 |