Page last updated: 2024-11-01

nicardipine and Hypotension

nicardipine has been researched along with Hypotension in 28 studies

Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"To investigate the effects of nicardipine-, nitroglycerin-, and prostaglandine E1-induced hypotension on cerebrovascular carbon dioxide (CO2) reactivity over a wide range of arterial CO2 tension (PaCO2) (PaCO2; range 25 to 50 mmHg)."9.09Effects of nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension on human cerebrovascular carbon dioxide reactivity during propofol-fentanyl anesthesia. ( Endoh, H; Honda, T; Komura, N; Shibue, C; Shimoji, K; Watanabe, I, 1999)
"We compared the efficacy of the combination of enalaprilat/labetalol with that of enalaprilat/nicardipine to prevent emergence postcraniotomy hypertension."9.09A comparative study between a calcium channel blocker (Nicardipine) and a combined alpha-beta-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery. ( Broad, C; Ferri, E; Kross, RA; Leung, D; Melendez, JA; Pratila, M; Veronesi, M, 2000)
"A placebo-controlled, double-blind multicenter trial was conducted in 123 patients with severe hypertension to examine the efficacy and safety of intravenously administered nicardipine hydrochloride in controlling blood pressure."9.06Intravenous nicardipine for the treatment of severe hypertension. A double-blind, placebo-controlled multicenter trial. ( Cheung, DG; Cook, ME; Davis, WR; Fletcher, E; Langford, HG; MacCarthy, EP; Ram, CV; Saunders, E; Townsend, R; Wallin, JD, 1989)
"Nicardipine is a potent drug to control hypertension during pregnancy with side effects including maternal headaches, nausea and tachycardia."8.90The optimal treatment of severe hypertension in pregnancy: update of the role of nicardipine. ( de Groot, CJ; Meuleman, T; Nooij, LS; Roelofs, R; Visser, S; Vos, P, 2014)
"In patients with hemorrhagic stroke, nicardipine appeared to have similar efficacy as clevidipine in SBP reduction, with a more likely reduction of rebound hypertension and drug cost."8.12Comparison of Clevidipine and Nicardipine for Acute Blood Pressure Reduction in Hemorrhagic Stroke. ( Breslin, J; Hanify, J; Heierman, T; Larizadeh, K; Phipps, W; Saldana, S; Sanchez, M, 2022)
"This multicenter, retrospective case series included all pregnant women beyond 20 weeks of gestation with severe antepartum hypertension that were treated with intravenous nicardipine."8.12Nicardipine for treating severe antepartum hypertension during pregnancy: Nine years of experience in more than 800 women. ( Cornette, JC; Duvekot, JJ; Edens, MA; Hengst, M; Huigen, S; Nij Bijvank, SW; Winkelen, AV, 2022)
"Patients were eligible if they had a diagnosis of an acute stroke and were administered either CIV-labetalol or CIV-nicardipine."8.02Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine? ( El-Ghoroury, H; Hecht, JP; Sudekum, DM, 2021)
"Nicardipine was associated with an increased risk of short-term mortality after acute ischemic stroke."7.91Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019)
"Intra-arterial (IA) nicardipine is often used to treat cerebral vasospasm associated with subarachnoid hemorrhage (SAH)."7.77High-dose intra-arterial nicardipine results in hypotension following vasospasm treatment in subarachnoid hemorrhage. ( Lazzaro, MA; Lopes, DK; Prabhakaran, S; Rosenberg, N, 2011)
"We concluded that cerebrovascular CO2 reactivity in insulin-dependent patients is impaired during nicardipine-induced hypotension under sevoflurane anesthesia."7.74Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia. ( Goto, F; Kadoi, Y, 2007)
"Nicardipine, a dihydropyridine type calcium channel blocker, was infused at two flow-rates into spontaneously hypertensive (SH) and control normotensive Wistar-Kyoto (WKY) rats (young, 6-week-old and adult, 23-week-old, n = 5) under pentobarbital anesthesia, to cause hypotension."7.70Changes of plasma L-arginine levels in spontaneously hypertensive rats under induced hypotension. ( Fukushima, T; Homma, H; Imai, K; Kasai, C; Matsunaga, H; Mori, T; Prados, P; Santa, T, 1999)
"Hepatic blood flow (HBF) and energy metabolism during moderate hypotension induced by prostaglandin E1 (PGE1) and nicardipine were studied by in vivo magnetic resonance spectroscopy."7.68Hepatic blood flow and energy metabolism during hypotension induced by prostaglandin E1 and nicardipine in rabbits: an in vivo magnetic resonance spectroscopic study. ( Arai, T; Inubushi, T; Kito, K; Mori, K; Morikawa, S, 1993)
"To induce deliberate hypotension during anesthesia, nicardipine was administered to patients undergoing total hip arthroplasty and was randomly compared with nitroprusside."7.68Deliberate hypotension with nicardipine or nitroprusside during total hip arthroplasty. ( Babin, M; Bernard, JM; François, T; Letenneur, J; Macquin-Mavier, I; Pinaud, M, 1991)
"Hemodynamic features of hypotension induced by nicardipine were studied in 18 mongrel dogs under 0."7.68[Hemodynamic features of hypotension induced by nicardipine in dogs]. ( Hosoyamada, A; Inada, Y; Matsui, K; Negishi, H; Takeda, S; Tashiro, N; Tomaru, T, 1990)
"Hypotension was the main side effect, and it occurred only in the two groups that received the highest doses."6.67Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study. ( Bourdeix, I; Chaumet-Riffaud, P; Massiou, H, 1992)
"To investigate the effects of nicardipine-, nitroglycerin-, and prostaglandine E1-induced hypotension on cerebrovascular carbon dioxide (CO2) reactivity over a wide range of arterial CO2 tension (PaCO2) (PaCO2; range 25 to 50 mmHg)."5.09Effects of nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension on human cerebrovascular carbon dioxide reactivity during propofol-fentanyl anesthesia. ( Endoh, H; Honda, T; Komura, N; Shibue, C; Shimoji, K; Watanabe, I, 1999)
"We compared the efficacy of the combination of enalaprilat/labetalol with that of enalaprilat/nicardipine to prevent emergence postcraniotomy hypertension."5.09A comparative study between a calcium channel blocker (Nicardipine) and a combined alpha-beta-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery. ( Broad, C; Ferri, E; Kross, RA; Leung, D; Melendez, JA; Pratila, M; Veronesi, M, 2000)
"A placebo-controlled, double-blind multicenter trial was conducted in 123 patients with severe hypertension to examine the efficacy and safety of intravenously administered nicardipine hydrochloride in controlling blood pressure."5.06Intravenous nicardipine for the treatment of severe hypertension. A double-blind, placebo-controlled multicenter trial. ( Cheung, DG; Cook, ME; Davis, WR; Fletcher, E; Langford, HG; MacCarthy, EP; Ram, CV; Saunders, E; Townsend, R; Wallin, JD, 1989)
"Nicardipine is a potent drug to control hypertension during pregnancy with side effects including maternal headaches, nausea and tachycardia."4.90The optimal treatment of severe hypertension in pregnancy: update of the role of nicardipine. ( de Groot, CJ; Meuleman, T; Nooij, LS; Roelofs, R; Visser, S; Vos, P, 2014)
"In patients with hemorrhagic stroke, nicardipine appeared to have similar efficacy as clevidipine in SBP reduction, with a more likely reduction of rebound hypertension and drug cost."4.12Comparison of Clevidipine and Nicardipine for Acute Blood Pressure Reduction in Hemorrhagic Stroke. ( Breslin, J; Hanify, J; Heierman, T; Larizadeh, K; Phipps, W; Saldana, S; Sanchez, M, 2022)
"This multicenter, retrospective case series included all pregnant women beyond 20 weeks of gestation with severe antepartum hypertension that were treated with intravenous nicardipine."4.12Nicardipine for treating severe antepartum hypertension during pregnancy: Nine years of experience in more than 800 women. ( Cornette, JC; Duvekot, JJ; Edens, MA; Hengst, M; Huigen, S; Nij Bijvank, SW; Winkelen, AV, 2022)
"Patients were eligible if they had a diagnosis of an acute stroke and were administered either CIV-labetalol or CIV-nicardipine."4.02Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine? ( El-Ghoroury, H; Hecht, JP; Sudekum, DM, 2021)
"Nicardipine was associated with an increased risk of short-term mortality after acute ischemic stroke."3.91Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019)
"Intra-arterial (IA) nicardipine is often used to treat cerebral vasospasm associated with subarachnoid hemorrhage (SAH)."3.77High-dose intra-arterial nicardipine results in hypotension following vasospasm treatment in subarachnoid hemorrhage. ( Lazzaro, MA; Lopes, DK; Prabhakaran, S; Rosenberg, N, 2011)
"We concluded that cerebrovascular CO2 reactivity in insulin-dependent patients is impaired during nicardipine-induced hypotension under sevoflurane anesthesia."3.74Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia. ( Goto, F; Kadoi, Y, 2007)
" This study was designed to investigate the acute effects of local application of a SMF to neck or pelvic region under pharmacologically modulated BP; norepinephrine (NE)-induced hypertension as well as an L-type voltage-gated Ca(2+) channel blocker, nicardipine (NIC)-induced hypotension in conscious rabbits."3.73Effects of neck exposure to 5.5 mT static magnetic field on pharmacologically modulated blood pressure in conscious rabbits. ( Ohkubo, C; Okano, H, 2005)
" Nicardipine provides a good control of vasoconstriction during phaeochromocytoma surgery with limited risk of serious hypotension after tumour removal."3.70Haemodynamic heterogeneity and treatment with the calcium channel blocker nicardipine during phaeochromocytoma surgery. ( Colson, P; Dareau, S; Mann, C; Ribstein, J; Ryckwaert, F, 1998)
"Nicardipine, a dihydropyridine type calcium channel blocker, was infused at two flow-rates into spontaneously hypertensive (SH) and control normotensive Wistar-Kyoto (WKY) rats (young, 6-week-old and adult, 23-week-old, n = 5) under pentobarbital anesthesia, to cause hypotension."3.70Changes of plasma L-arginine levels in spontaneously hypertensive rats under induced hypotension. ( Fukushima, T; Homma, H; Imai, K; Kasai, C; Matsunaga, H; Mori, T; Prados, P; Santa, T, 1999)
"To induce deliberate hypotension during anesthesia, nicardipine was administered to patients undergoing total hip arthroplasty and was randomly compared with nitroprusside."3.68Deliberate hypotension with nicardipine or nitroprusside during total hip arthroplasty. ( Babin, M; Bernard, JM; François, T; Letenneur, J; Macquin-Mavier, I; Pinaud, M, 1991)
"Hepatic blood flow (HBF) and energy metabolism during moderate hypotension induced by prostaglandin E1 (PGE1) and nicardipine were studied by in vivo magnetic resonance spectroscopy."3.68Hepatic blood flow and energy metabolism during hypotension induced by prostaglandin E1 and nicardipine in rabbits: an in vivo magnetic resonance spectroscopic study. ( Arai, T; Inubushi, T; Kito, K; Mori, K; Morikawa, S, 1993)
"Hemodynamic features of hypotension induced by nicardipine were studied in 18 mongrel dogs under 0."3.68[Hemodynamic features of hypotension induced by nicardipine in dogs]. ( Hosoyamada, A; Inada, Y; Matsui, K; Negishi, H; Takeda, S; Tashiro, N; Tomaru, T, 1990)
"Intracerebroventricular injections of nicardipine (10 micrograms/kg) to SHR induced hypotension which was suppressed by pretreatment with 6-OHDA."3.67Endogenous opiate system and dihydropyridine-induced central regulation of sympathetic tone in rats. ( Brisac, AM; Champeroux, P; Laurent, S; Schmitt, H, 1988)
"Hypotension was the main side effect, and it occurred only in the two groups that received the highest doses."2.67Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study. ( Bourdeix, I; Chaumet-Riffaud, P; Massiou, H, 1992)
"Outcome of patients with aneurysmal subarachnoid hemorrhage (SAH) has improved over the last decades."2.49SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials. ( Cusimano, MD; Etminan, N; Hanggi, D; Hasan, D; Ilodigwe, D; Jaja, B; Lantigua, H; Le Roux, P; Lo, B; Louffat-Olivares, A; Macdonald, RL; Mayer, S; Molyneux, A; Quinn, A; Schenk, T; Schweizer, TA; Singh, J; Spears, J; Todd, M; Torner, J; Vergouwen, MD; Wong, GK, 2013)
"We present a case of neurogenic stunned myocardium, discovered intraoperatively after anesthetic induction, in a patient who presented to our operating room with a recent intraparenchymal hemorrhage."1.43Prolonged Cardiac Dysfunction After Intraparenchymal Hemorrhage and Neurogenic Stunned Myocardium. ( Krishnamoorthy, V; Sharma, D; Vavilala, MS; Wilson, T, 2016)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.14)18.7374
1990's10 (35.71)18.2507
2000's4 (14.29)29.6817
2010's8 (28.57)24.3611
2020's4 (14.29)2.80

Authors

AuthorsStudies
Saldana, S1
Breslin, J1
Hanify, J1
Heierman, T1
Larizadeh, K1
Sanchez, M1
Phipps, W1
Nij Bijvank, SW1
Hengst, M1
Cornette, JC1
Huigen, S1
Winkelen, AV1
Edens, MA1
Duvekot, JJ1
Ibarra, F1
Holzmann, S1
Shah, S1
Fountain, C1
Saleh, S1
Kapoor, V1
Dang, T1
El-Ghoroury, H1
Sudekum, DM1
Hecht, JP1
Sadeghi, M1
Saber, H1
Singh, A1
Hanni, C1
Parker, D1
Desai, A1
Mohamed, W1
Macdonald, RL1
Jaja, B1
Cusimano, MD1
Etminan, N1
Hanggi, D1
Hasan, D1
Ilodigwe, D1
Lantigua, H1
Le Roux, P1
Lo, B1
Louffat-Olivares, A1
Mayer, S1
Molyneux, A1
Quinn, A1
Schweizer, TA1
Schenk, T1
Spears, J1
Todd, M1
Torner, J1
Vergouwen, MD1
Wong, GK1
Singh, J1
Nooij, LS1
Visser, S1
Meuleman, T1
Vos, P1
Roelofs, R1
de Groot, CJ1
Lhommet, P1
Espitalier, F1
Merlini, T1
Marchand, E1
Aupart, M1
Martinez, R1
Krishnamoorthy, V1
Wilson, T1
Sharma, D1
Vavilala, MS1
Kurowski, D1
Mullen, MT1
Messé, SR1
Rosenberg, N1
Lazzaro, MA1
Lopes, DK1
Prabhakaran, S1
Haile, M1
Galoyan, S1
Li, YS1
Cohen, BH1
Quartermain, D1
Blanck, T1
Bekker, A1
Shinozuka, K1
Umegaki, K1
Kubota, Y1
Tanaka, N1
Mizuno, H1
Yamauchi, J1
Nakamura, K1
Kunitomo, M1
Okano, H1
Ohkubo, C1
Kadoi, Y1
Goto, F1
Connelly, CM1
Waksmonski, C1
Gagnon, MM1
Lipsitz, LA1
Kito, K1
Arai, T1
Mori, K1
Morikawa, S1
Inubushi, T1
Balakumaran, A1
Campbell, GA1
Moslen, MT1
Colson, P1
Ryckwaert, F1
Ribstein, J1
Mann, C1
Dareau, S1
Prados, P1
Matsunaga, H1
Mori, T1
Santa, T1
Fukushima, T1
Homma, H1
Kasai, C1
Imai, K1
Endoh, H1
Honda, T1
Komura, N1
Shibue, C1
Watanabe, I1
Shimoji, K1
Kross, RA1
Ferri, E1
Leung, D1
Pratila, M1
Broad, C1
Veronesi, M1
Melendez, JA1
Morooka, H1
Gotoh, S1
Makita, T1
Fukuzaki, M1
Shibata, O1
Gotoh, Y1
Massiou, H1
Chaumet-Riffaud, P1
Bourdeix, I1
Bernard, JM1
Pinaud, M1
François, T1
Babin, M1
Macquin-Mavier, I1
Letenneur, J1
Takeda, S1
Inada, Y1
Tashiro, N1
Matsui, K1
Tomaru, T1
Negishi, H1
Hosoyamada, A1
Wallin, JD1
Fletcher, E1
Ram, CV1
Cook, ME1
Cheung, DG1
MacCarthy, EP1
Townsend, R1
Saunders, E1
Davis, WR1
Langford, HG1
Champeroux, P1
Brisac, AM1
Laurent, S1
Schmitt, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429]Phase 4144 participants (Anticipated)Interventional2019-04-05Recruiting
Nicardipine Versus Esmolol for Management of Emergence Hypertension After Craniotomy[NCT01951950]Phase 140 participants (Actual)Interventional2013-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Failure of Drug to Control Systolic Blood Pressure (SBP) < 140 mmHg

(NCT01951950)
Timeframe: 1 hour postoperatively

Interventionparticipants (Number)
Nicardipine1
Esmolol11

Reviews

2 reviews available for nicardipine and Hypotension

ArticleYear
SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials.
    Translational stroke research, 2013, Volume: 4, Issue:3

    Topics: Antioxidants; Brain Infarction; Calcium Channel Blockers; Critical Care; Dioxanes; Drug Therapy, Com

2013
The optimal treatment of severe hypertension in pregnancy: update of the role of nicardipine.
    Current pharmaceutical biotechnology, 2014, Volume: 15, Issue:1

    Topics: Antihypertensive Agents; Female; Humans; Hypertension; Hypotension; Infant, Newborn; Labetalol; Nica

2014

Trials

5 trials available for nicardipine and Hypotension

ArticleYear
Effects of isosorbide dinitrate and nicardipine hydrochloride on postprandial blood pressure in elderly patients with stable angina pectoris or healed myocardial infarction.
    The American journal of cardiology, 1995, Feb-01, Volume: 75, Issue:4

    Topics: Aged; Angina Pectoris; Blood Pressure; Cross-Over Studies; Double-Blind Method; Eating; Female; Huma

1995
Effects of nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension on human cerebrovascular carbon dioxide reactivity during propofol-fentanyl anesthesia.
    Journal of clinical anesthesia, 1999, Volume: 11, Issue:7

    Topics: Adult; Alprostadil; Analysis of Variance; Anesthetics, Intravenous; Antihypertensive Agents; Blood F

1999
A comparative study between a calcium channel blocker (Nicardipine) and a combined alpha-beta-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Anesth

2000
A comparative study between a calcium channel blocker (Nicardipine) and a combined alpha-beta-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Anesth

2000
A comparative study between a calcium channel blocker (Nicardipine) and a combined alpha-beta-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Anesth

2000
A comparative study between a calcium channel blocker (Nicardipine) and a combined alpha-beta-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Anesth

2000
Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study.
    Surgical neurology, 1992, Volume: 38, Issue:1

    Topics: Administration, Oral; Adult; Aged; Chi-Square Distribution; Female; Humans; Hypotension; Infusions,

1992
Intravenous nicardipine for the treatment of severe hypertension. A double-blind, placebo-controlled multicenter trial.
    Archives of internal medicine, 1989, Volume: 149, Issue:12

    Topics: Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Headache; Humans;

1989

Other Studies

21 other studies available for nicardipine and Hypotension

ArticleYear
Comparison of Clevidipine and Nicardipine for Acute Blood Pressure Reduction in Hemorrhagic Stroke.
    Neurocritical care, 2022, Volume: 36, Issue:3

    Topics: Acute Kidney Injury; Adult; Antihypertensive Agents; Blood Pressure; Bradycardia; Hematoma; Hemorrha

2022
Nicardipine for treating severe antepartum hypertension during pregnancy: Nine years of experience in more than 800 women.
    Acta obstetricia et gynecologica Scandinavica, 2022, Volume: 101, Issue:9

    Topics: Antihypertensive Agents; Blood Pressure; Cesarean Section; Female; Humans; Hypertension; Hypotension

2022
Utility of nicardipine in the management of hypertensive crises in adults with reduced ejection fractions.
    The American journal of emergency medicine, 2024, Volume: 75

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Bradycardia; Heart Failure; Humans; Hypertension; Hy

2024
Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine?
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021, Volume: 30, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pre

2021
Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019, Volume: 28, Issue:5

    Topics: Aged; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Critical Illness; Databases, Factual;

2019
Tolerance of rapid right ventricular pacing during thoracic endovascular aortic repair.
    Annals of vascular surgery, 2015, Volume: 29, Issue:3

    Topics: Aged; Aorta, Thoracic; Aortic Diseases; Biomarkers; Blood Vessel Prosthesis Implantation; Cardiac Pa

2015
Prolonged Cardiac Dysfunction After Intraparenchymal Hemorrhage and Neurogenic Stunned Myocardium.
    A & A case reports, 2016, Jan-01, Volume: 6, Issue:1

    Topics: Adult; Anesthesia, General; Cerebral Hemorrhage; Emergency Service, Hospital; Heart; Hemangioma, Cav

2016
Pearls & Oy-sters: Iatrogenic relative hypotension leading to diffuse internal borderzone infarctions and coma.
    Neurology, 2016, 06-14, Volume: 86, Issue:24

    Topics: Adult; Antihypertensive Agents; Brain Infarction; Coma; Diffusion Magnetic Resonance Imaging; Fatal

2016
High-dose intra-arterial nicardipine results in hypotension following vasospasm treatment in subarachnoid hemorrhage.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Cerebral Angiography; Circle of Willis; Dose-Respons

2011
Nimodipine-induced hypotension but not nitroglycerin-induced hypotension preserves long- and short-term memory in adult mice.
    Anesthesia and analgesia, 2012, Volume: 114, Issue:5

    Topics: Animals; Avoidance Learning; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cer

2012
Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.
    Life sciences, 2002, Apr-26, Volume: 70, Issue:23

    Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 Enzyme System; Diet; D

2002
Effects of neck exposure to 5.5 mT static magnetic field on pharmacologically modulated blood pressure in conscious rabbits.
    Bioelectromagnetics, 2005, Volume: 26, Issue:6

    Topics: Animals; Baroreflex; Blood Pressure; Bradycardia; Calcium Channel Blockers; Carotid Sinus; Conscious

2005
Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia.
    Journal of anesthesia, 2007, Volume: 21, Issue:2

    Topics: Aged; Anesthetics, Inhalation; Antihypertensive Agents; Blood Pressure; Carbon Dioxide; Cerebrovascu

2007
Hepatic blood flow and energy metabolism during hypotension induced by prostaglandin E1 and nicardipine in rabbits: an in vivo magnetic resonance spectroscopic study.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:3

    Topics: Adenosine Triphosphate; Alprostadil; Animals; Blood Pressure; Energy Metabolism; Hypotension; Liver;

1993
Calcium channel blockers induce thymic apoptosis in vivo in rats.
    Toxicology and applied pharmacology, 1996, Volume: 139, Issue:1

    Topics: Animals; Apoptosis; Calcium Channel Blockers; Chlorpromazine; Diltiazem; Dopamine Antagonists; Dose-

1996
Haemodynamic heterogeneity and treatment with the calcium channel blocker nicardipine during phaeochromocytoma surgery.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:9

    Topics: Adrenal Gland Neoplasms; Adult; Aged; Arrhythmias, Cardiac; Calcium Channel Blockers; Female; Hemody

1998
Changes of plasma L-arginine levels in spontaneously hypertensive rats under induced hypotension.
    Biomedical chromatography : BMC, 1999, Volume: 13, Issue:1

    Topics: Animals; Antihypertensive Agents; Arginine; Calcium Channel Blockers; Hypertension; Hypotension; Mal

1999
[Adrenal catecholamine releases during hypotension with continuous administration of calcium entry blockers and nitroglycerin].
    Masui. The Japanese journal of anesthesiology, 1992, Volume: 41, Issue:7

    Topics: Adrenal Glands; Animals; Diltiazem; Dogs; Epinephrine; Hypotension; Male; Nicardipine; Nitroglycerin

1992
Deliberate hypotension with nicardipine or nitroprusside during total hip arthroplasty.
    Anesthesia and analgesia, 1991, Volume: 73, Issue:3

    Topics: Aged; Anesthesia, Inhalation; Epinephrine; Female; Fentanyl; Hemodynamics; Hip Prosthesis; Humans; H

1991
[Hemodynamic features of hypotension induced by nicardipine in dogs].
    Masui. The Japanese journal of anesthesiology, 1990, Volume: 39, Issue:12

    Topics: Animals; Dogs; Hemodynamics; Hypotension; Nicardipine

1990
Endogenous opiate system and dihydropyridine-induced central regulation of sympathetic tone in rats.
    European journal of pharmacology, 1988, Dec-06, Volume: 158, Issue:1-2

    Topics: Animals; Blood Pressure; Dihydropyridines; Endorphins; Hydroxydopamines; Hypotension; Male; Naloxone

1988