nicardipine has been researched along with Glial Cell Tumors in 9 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, whether glioma stem cells (GSCs) can be sensitized to chemotherapy via combined treatment with temozolomide (TMZ) and nicardipine is unclear." | 8.02 | Nicardipine sensitizes temozolomide by inhibiting autophagy and promoting cell apoptosis in glioma stem cells. ( Dong, J; Dong, X; Jiang, Q; Li, H; Liu, L; Shi, J; Wang, H; Wang, L, 2021) |
| "Using the monolay tumor cell culture system and the method or MTT colorimetric analysis, the cytotoxicity of the anticancer drug VM-26 and Nicardipine(NCDP) in human malignant glioma cell line U251 was studied." | 7.70 | [Enhanced cytotoxicity of VM-26 in human malignant glioma cells by calcium channel blocker nicardipine in vitro]. ( Chen, B; Hu, S; Huang, C, 1999) |
| " However, whether glioma stem cells (GSCs) can be sensitized to chemotherapy via combined treatment with temozolomide (TMZ) and nicardipine is unclear." | 4.02 | Nicardipine sensitizes temozolomide by inhibiting autophagy and promoting cell apoptosis in glioma stem cells. ( Dong, J; Dong, X; Jiang, Q; Li, H; Liu, L; Shi, J; Wang, H; Wang, L, 2021) |
| "Using the monolay tumor cell culture system and the method or MTT colorimetric analysis, the cytotoxicity of the anticancer drug VM-26 and Nicardipine(NCDP) in human malignant glioma cell line U251 was studied." | 3.70 | [Enhanced cytotoxicity of VM-26 in human malignant glioma cells by calcium channel blocker nicardipine in vitro]. ( Chen, B; Hu, S; Huang, C, 1999) |
| "Membrane-modifying agents such as reserpine, calcium antagonists (nicardipine, verapamil) and calmodulin inhibitor (trifluoperazine) were found to enhance the cytotoxicity of ACNU in vitro and in vivo in ACNU-resistant C 6 (C 6/ACNU) glioma." | 3.67 | [Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma]. ( Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, J | 1 |
| Dong, X | 1 |
| Li, H | 1 |
| Wang, H | 1 |
| Jiang, Q | 1 |
| Liu, L | 1 |
| Wang, L | 1 |
| Dong, J | 1 |
| Jin, Y | 1 |
| Bin, ZQ | 1 |
| Qiang, H | 1 |
| Liang, C | 1 |
| Hua, C | 1 |
| Jun, D | 1 |
| Dong, WA | 1 |
| Qing, L | 1 |
| Nomura, K | 1 |
| Watanabe, T | 1 |
| Nakamura, O | 1 |
| Shibui, S | 1 |
| Li, SN | 1 |
| Bräter, M | 1 |
| Andreas, K | 1 |
| Saqr, HE | 1 |
| Guan, Z | 1 |
| Yates, AJ | 1 |
| Stokes, BT | 1 |
| Hu, S | 1 |
| Huang, C | 1 |
| Chen, B | 1 |
| Yoshida, T | 2 |
| Shimizu, K | 2 |
| Ushio, Y | 2 |
| Hayakawa, T | 1 |
| Kato, A | 1 |
| Mogami, H | 2 |
| Sakamoto, Y | 2 |
| Kaba, K | 1 |
| Tani, E | 1 |
| Morimura, T | 1 |
| Matsumoto, T | 1 |
9 other studies available for nicardipine and Glial Cell Tumors
| Article | Year |
|---|---|
Nicardipine sensitizes temozolomide by inhibiting autophagy and promoting cell apoptosis in glioma stem cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Brain Neoplasms; Calcium Channel Blockers; | 2021 |
ABCG2 is related with the grade of glioma and resistance to mitoxantone, a chemotherapeutic drug for glioma.
Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; | 2009 |
[Flow cytometric study of enhanced effect of anti-cancer drugs induced by nicardipine hydrochloride].
Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; DNA, Neoplasm; Doxorubicin; Flow Cytometry | 1984 |
Nicardipine inhibits N-type calcium channels in dbcAMP-differentiated neuroblastoma x glioma hybrid cells (NG 108-15 cells).
Topics: Bucladesine; Calcium Channel Blockers; Calcium Channels; Cell Transformation, Neoplastic; Glioma; Hu | 1999 |
Mechanisms through which PDGF alters intracellular calcium levels in U-1242 MG human glioma cells.
Topics: Becaplermin; Brain Neoplasms; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium | 1999 |
[Enhanced cytotoxicity of VM-26 in human malignant glioma cells by calcium channel blocker nicardipine in vitro].
Topics: Antineoplastic Agents; Brain Neoplasms; Calcium Channel Blockers; Drug Synergism; Glioma; Humans; Ni | 1999 |
[Mechanism and overcoming of resistance in ACNU-resistant sublines of rat brain tumors].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Membrane Permeability; Drug Resistance; Glioma | 1986 |
[Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cells, Cultured; Drug Resistance; Drug T | 1986 |
Potentiation of vincristine effect in human and murine gliomas by calcium channel blockers or calmodulin inhibitors.
Topics: Animals; Brain Neoplasms; Calcium Channel Blockers; Calmodulin; Drug Synergism; Glioma; Humans; In V | 1985 |