nicardipine has been researched along with Diabetes Mellitus, Type 2 in 15 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind, placebo-controlled study was carried out over 120 days to assess the metabolic tolerance and patient acceptability of nicardipine in 20 patients with Type 2 diabetes mellitus and slight hypertension." | 9.06 | The influence of nicardipine in type 2 diabetic patients with slight hypertension. ( Faguer de Moustier, B; Paoli, V, 1990) |
| "The purpose of this study was to examine the effects of nicardipine-induced hypotension on cerebrovascular CO2 reactivity in patients with diabetes mellitus under sevoflurane anesthesia." | 7.74 | Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia. ( Goto, F; Kadoi, Y, 2007) |
| "Renal hemodynamics was investigated in 25 patients." | 6.68 | Effects of benazepril and nicardipine on microalbuminuria in normotensive and hypertensive patients with diabetes. ( Andriani, A; Bertocchi, F; Bonfantino, MV; Cavallo, A; De Cesaris, R; Lamontanara, G; Ranieri, G, 1996) |
| "The effect of the calcium antagonist nicardipine on insulin secretion and glucose homoeostasis was investigated in elderly hypertensives with and without diabetes mellitus; 15 patients with essential hypertension for at least 10 years and normal glucose tolerance according to standard criteria (Group I) and 15 elderly hypertensive patients affected by Type 2 diabetes mellitus and on treatment with diet or oral drugs (Group 2)." | 5.07 | Nicardipine does not cause deterioration of glucose homoeostasis in man: a placebo controlled study in elderly hypertensives with and without diabetes mellitus. ( Ceriello, A; D'Onofrio, F; Giugliano, D; Paolisso, G; Saccomanno, F; Torella, R; Varricchio, M, 1992) |
| "A double-blind, placebo-controlled study was carried out over 120 days to assess the metabolic tolerance and patient acceptability of nicardipine in 20 patients with Type 2 diabetes mellitus and slight hypertension." | 5.06 | The influence of nicardipine in type 2 diabetic patients with slight hypertension. ( Faguer de Moustier, B; Paoli, V, 1990) |
| "Seven of eight hypertensive Type 2 (non-insulin-dependent) diabetic patients with microalbuminuria completed a randomised crossover trial to compare the renal effects of angiotensin converting enzyme inhibitor (enalapril) and calcium antagonist (nicardipine)." | 5.06 | Comparison of the renal effects of angiotensin converting enzyme inhibitor and calcium antagonist in hypertensive type 2 (non-insulin-dependent) diabetic patients with microalbuminuria: a randomised controlled trial. ( Baba, T; Murabayashi, S; Takebe, K, 1989) |
| "The purpose of this study was to examine the effects of nicardipine-induced hypotension on cerebrovascular CO2 reactivity in patients with diabetes mellitus under sevoflurane anesthesia." | 3.74 | Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia. ( Goto, F; Kadoi, Y, 2007) |
| "The renal effects of oral maintenance doses of nicardipine 60-120 mg/day have been studied in 18 hypertensive patients with Type 2 (non-insulin-dependent) diabetes mellitus: 6 with normoalbuminuria (urinary albumin excretion rate, AER less than 20 micrograms." | 3.68 | Renal effects of nicardipine, a calcium antagonist, in hypertensive type 2 (non-insulin-dependent) diabetic patients with and without nephropathy. ( Baba, T; Murabayashi, S; Takebe, K; Tomiyama, T, 1990) |
| "Renal hemodynamics was investigated in 25 patients." | 2.68 | Effects of benazepril and nicardipine on microalbuminuria in normotensive and hypertensive patients with diabetes. ( Andriani, A; Bertocchi, F; Bonfantino, MV; Cavallo, A; De Cesaris, R; Lamontanara, G; Ranieri, G, 1996) |
| "The worldwide incidence of coronavirus disease 2019 (COVID-19) infection is rapidly increasing, but there exists limited information on coronavirus disease 2019 in pregnancy." | 1.56 | Coronavirus disease 2019 in pregnancy: early lessons. ( Baptiste, C; Breslin, N; D'Alton, M; Fuchs, K; Goffman, D; Gyamfi-Bannerman, C; Miller, R, 2020) |
| "90 min on chronic administration of nicardipine; insulin 2." | 1.28 | Effect of nicardipine on insulin secretion, glucose and lipid metabolism in hypertensive, non-insulin dependent diabetics. ( Capaldo, B; Di Bonito, P; Ferrara, AL; Iovine, C; Mancini, M; Pasanisi, F; Vaccaro, O, 1989) |
| "Nicardipine was used to control hypertensive episodes." | 1.27 | Blood glucose control by an artificial endocrine pancreas in a patient with phaeochromocytoma. ( Hamaji, M; Kawamori, R; Kawashima, Y; Mashimo, T; Miyata, M; Nakao, K; Shichiri, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Breslin, N | 1 |
| Baptiste, C | 1 |
| Miller, R | 1 |
| Fuchs, K | 1 |
| Goffman, D | 1 |
| Gyamfi-Bannerman, C | 1 |
| D'Alton, M | 1 |
| Kadoi, Y | 1 |
| Goto, F | 1 |
| Sasaki, H | 1 |
| Naka, K | 1 |
| Kishi, Y | 1 |
| Ohoshi, T | 1 |
| Hagihara, T | 1 |
| Matsuo, H | 1 |
| Sowa, R | 1 |
| Matsumoto, G | 1 |
| Sanke, T | 1 |
| Nanjo, K | 1 |
| De Cesaris, R | 1 |
| Ranieri, G | 1 |
| Andriani, A | 1 |
| Lamontanara, G | 1 |
| Cavallo, A | 1 |
| Bonfantino, MV | 1 |
| Bertocchi, F | 1 |
| Yoo, HJ | 1 |
| Kozaki, K | 1 |
| Akishita, M | 1 |
| Watanabe, M | 1 |
| Eto, M | 1 |
| Nagano, K | 1 |
| Sudo, N | 1 |
| Hashimoto, M | 1 |
| Kim, S | 1 |
| Yoshizumi, M | 1 |
| Toba, K | 1 |
| Ouchi, Y | 1 |
| Faguer de Moustier, B | 1 |
| Paoli, V | 1 |
| Giugliano, D | 1 |
| Saccomanno, F | 1 |
| Paolisso, G | 1 |
| Ceriello, A | 1 |
| Torella, R | 1 |
| Varricchio, M | 1 |
| D'Onofrio, F | 1 |
| Antonicelli, R | 1 |
| Pagelli, P | 1 |
| Paciaroni, E | 1 |
| Baba, T | 2 |
| Tomiyama, T | 1 |
| Murabayashi, S | 2 |
| Takebe, K | 2 |
| Stornello, M | 1 |
| Valvo, EV | 1 |
| Scapellato, L | 1 |
| Pasanisi, F | 1 |
| Vaccaro, O | 1 |
| Ferrara, AL | 1 |
| Di Bonito, P | 1 |
| Capaldo, B | 1 |
| Iovine, C | 1 |
| Mancini, M | 1 |
| Belleville, I | 1 |
| Vaillant, G | 1 |
| Farnier, M | 1 |
| Brun, JM | 1 |
| Collins, WC | 1 |
| Cullen, MJ | 1 |
| Feely, J | 1 |
| Hamaji, M | 1 |
| Miyata, M | 1 |
| Kawamori, R | 1 |
| Shichiri, M | 1 |
| Mashimo, T | 1 |
| Nakao, K | 1 |
| Kawashima, Y | 1 |
7 trials available for nicardipine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Effects of benazepril and nicardipine on microalbuminuria in normotensive and hypertensive patients with diabetes.
Topics: Adult; Aged; Albuminuria; Antihypertensive Agents; Benzazepines; Diabetes Mellitus, Type 1; Diabetes | 1996 |
The influence of nicardipine in type 2 diabetic patients with slight hypertension.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hypertension; Male; Mid | 1990 |
Nicardipine does not cause deterioration of glucose homoeostasis in man: a placebo controlled study in elderly hypertensives with and without diabetes mellitus.
Topics: Aged; Arginine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucagon; Glucose Toler | 1992 |
Nicardipine retard in the therapy of elderly diabetic hypertensives: final report of observational study.
Topics: Aged; Aging; Analysis of Variance; Blood Glucose; Blood Pressure; Delayed-Action Preparations; Diabe | 1992 |
Hemodynamic, renal, and humoral effects of the calcium entry blocker nicardipine and converting enzyme inhibitor captopril in hypertensive type II diabetic patients with nephropathy.
Topics: Adult; Blood Pressure; Captopril; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Combinatio | 1989 |
Comparison of the renal effects of angiotensin converting enzyme inhibitor and calcium antagonist in hypertensive type 2 (non-insulin-dependent) diabetic patients with microalbuminuria: a randomised controlled trial.
Topics: Aged; Albuminuria; Blood Pressure; Blood Proteins; Clinical Trials as Topic; Diabetes Mellitus, Type | 1989 |
Calcium channel blocker drugs and diabetic control.
Topics: Adult; Aged; Blood Glucose; Calcium Channel Blockers; Clinical Trials as Topic; Diabetes Mellitus, T | 1987 |
8 other studies available for nicardipine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Coronavirus disease 2019 in pregnancy: early lessons.
Topics: Acute Kidney Injury; Adult; Anesthesia, General; Anti-Bacterial Agents; Antihypertensive Agents; Azi | 2020 |
Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia.
Topics: Aged; Anesthetics, Inhalation; Antihypertensive Agents; Blood Pressure; Carbon Dioxide; Cerebrovascu | 2007 |
Nicardipine may impair glucose metabolism in hypertensive diabetic patients.
Topics: Adult; Aged; Atenolol; Carteolol; Diabetes Mellitus, Type 2; Diltiazem; Enalapril; Female; Glucose; | 1994 |
Augmented Ca2+ influx is involved in the mechanism of enhanced proliferation of cultured vascular smooth muscle cells from spontaneously diabetic Goto-Kakizaki rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Renal effects of nicardipine, a calcium antagonist, in hypertensive type 2 (non-insulin-dependent) diabetic patients with and without nephropathy.
Topics: Albuminuria; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; | 1990 |
Effect of nicardipine on insulin secretion, glucose and lipid metabolism in hypertensive, non-insulin dependent diabetics.
Topics: Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Female; Heart Rate; Humans; Hyperte | 1989 |
[Nicardipine may have an adverse effect on the blood sugar equilibrium of non-insulin-dependent diabetics].
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Humans; Male; Middle Aged; Nicardipine | 1987 |
Blood glucose control by an artificial endocrine pancreas in a patient with phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Blood Glucose; Calcium Channel Blockers; Catecholamines; Diabetes Mellitus, | 1985 |