nicardipine has been researched along with Cerebral Infarction in 17 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe a patient who developed reversible segmental cerebral arterial vasospasm and cerebral infarction while taking excessive amounts of sumatriptan succinate and a combination drug (Midrin) consisting of isometheptene mucate, 65 mg, dichloralphenazone, 100 mg, and acetaminophen, 325 mg." | 8.80 | Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin. ( Biller, J; Malkoff, MD; Meschia, JF, 1998) |
| "To develop a nicardipine prolonged-release implant (NPRI) to prevent cerebral vasospasm in patients with subarachnoid hemorrhage in 1999, which may be used during craniotomy, and report the results of our recent 12-year single critical care center experience." | 7.96 | Twelve-year single critical care center experience of nicardipine prolonged-release implants in patients with subarachnoid hemorrhage: a propensity score matching analysis. ( Arai, N; Funaki, A; Hagiwara, S; Itoh, T; Kasuya, H; Kuroi, Y; Ohbuchi, H; Sasahara, A; Sato, Y; Takahashi, Y, 2020) |
| "Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery." | 7.68 | Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats. ( Karasawa, A; Kubo, K; Sano, J; Shirakura, S, 1992) |
| "We evaluated the effect of nicardipine, a calcium channel blocker, on somatosensory evoked potentials (SEP) in 26 patients with acute cerebral infarction." | 7.68 | Effect of nicardipine on somatosensory evoked potentials in patients with acute cerebral infarction. ( Ding, DY; Yao, LP, 1990) |
| "One of the challenges in bringing new therapeutic agents (since nimodipine) in for the treatment of cerebral ischemia associated with aneurysmal subarachnoid hemorrhage (aSAH) is the incongruence in therapeutic benefit observed between phase II and subsequent phase III clinical trials." | 5.22 | Lessons Learned from Phase II and Phase III Trials Investigating Therapeutic Agents for Cerebral Ischemia Associated with Aneurysmal Subarachnoid Hemorrhage. ( Broderick, JP; Cassarly, CN; Huang, W; Ishfaq, MF; Lobanova, I; Macdonald, RL; Martin, RH; Qureshi, AI; Suarez, JI, 2022) |
| "To describe a patient who developed reversible segmental cerebral arterial vasospasm and cerebral infarction while taking excessive amounts of sumatriptan succinate and a combination drug (Midrin) consisting of isometheptene mucate, 65 mg, dichloralphenazone, 100 mg, and acetaminophen, 325 mg." | 4.80 | Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin. ( Biller, J; Malkoff, MD; Meschia, JF, 1998) |
| "To develop a nicardipine prolonged-release implant (NPRI) to prevent cerebral vasospasm in patients with subarachnoid hemorrhage in 1999, which may be used during craniotomy, and report the results of our recent 12-year single critical care center experience." | 3.96 | Twelve-year single critical care center experience of nicardipine prolonged-release implants in patients with subarachnoid hemorrhage: a propensity score matching analysis. ( Arai, N; Funaki, A; Hagiwara, S; Itoh, T; Kasuya, H; Kuroi, Y; Ohbuchi, H; Sasahara, A; Sato, Y; Takahashi, Y, 2020) |
| " DESIGN OF STUDIES: Mean cerebral circulation parameters were studied in chronic stroke patients with hypertension and treated acutely or chronically (2 weeks) with nicardipine or nifedipine retard." | 3.68 | Effects of dihydropyridines on cerebral blood vessels. ( Hashimoto, H; Kuriyama, Y; Nagatsuka, K; Omae, T; Sawada, T, 1993) |
| "Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery." | 3.68 | Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats. ( Karasawa, A; Kubo, K; Sano, J; Shirakura, S, 1992) |
| "The effects of nilvadipine, a dihydropyridine type calcium channel blocker, on cerebral infarction induced by focal brain ischemia was studied in rats." | 3.68 | Nilvadipine, a new calcium channel blocker, reduces ischemic brain injury in rats. ( Handa, J; Mori, J; Satoh, H; Shiino, A; Susumu, T; Takakura, S, 1991) |
| "We evaluated the effect of nicardipine, a calcium channel blocker, on somatosensory evoked potentials (SEP) in 26 patients with acute cerebral infarction." | 3.68 | Effect of nicardipine on somatosensory evoked potentials in patients with acute cerebral infarction. ( Ding, DY; Yao, LP, 1990) |
| "(Stroke 17, 472-476, 1986) and cerebral infarct size (CIS) determined by the 2,3,5-triphenyltetrazolium chloride staining method were measured 24 hr after MCAO." | 1.30 | Effects of a calcium antagonist, lacidipine, on experimental focal cerebral ischemia in rats. ( Akada, Y; Funato, H; Katsuki, Y; Kawano, H; Sato, M; Uemura, A, 1997) |
| "There were no further episodes of transient ischemic attacks, seizures, or headache in one patient and decreased frequency in the other." | 1.29 | Use of a calcium channel blocker (nicardipine HCl) in the treatment of childhood moyamoya disease. ( Fish, I; Forem, SL; Hosain, SA; Hughes, JT; Wisoff, J, 1994) |
| "In addition, evolution of cerebral infarction was studied at 6 hours and 12 hours post-occlusion by magnetic resonance imaging (MRI)." | 1.28 | [Ca++ antagonist and acute brain ischemia: effects of nilvadipine and nicardipine on middle cerebral artery occlusion in rats]. ( Handa, J; Inubushi, T; Kido, C; Matsuda, M; Morikawa, S; Shiino, A; Susumu, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (76.47) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Qureshi, AI | 1 |
| Lobanova, I | 1 |
| Huang, W | 1 |
| Ishfaq, MF | 1 |
| Broderick, JP | 1 |
| Cassarly, CN | 1 |
| Martin, RH | 1 |
| Macdonald, RL | 1 |
| Suarez, JI | 1 |
| Kuroi, Y | 1 |
| Ohbuchi, H | 1 |
| Arai, N | 1 |
| Takahashi, Y | 1 |
| Hagiwara, S | 1 |
| Sasahara, A | 1 |
| Funaki, A | 1 |
| Itoh, T | 1 |
| Sato, Y | 1 |
| Kasuya, H | 1 |
| Chalouhi, N | 1 |
| Tjoumakaris, S | 1 |
| Thakkar, V | 1 |
| Theofanis, T | 1 |
| Hammer, C | 1 |
| Hasan, D | 1 |
| Starke, RM | 1 |
| Wu, C | 1 |
| Gonzalez, LF | 1 |
| Rosenwasser, R | 1 |
| Jabbour, P | 1 |
| Hosain, SA | 1 |
| Hughes, JT | 1 |
| Forem, SL | 1 |
| Wisoff, J | 1 |
| Fish, I | 1 |
| Weir, B | 1 |
| MacDonald, L | 1 |
| Kuriyama, Y | 1 |
| Hashimoto, H | 1 |
| Nagatsuka, K | 1 |
| Sawada, T | 1 |
| Omae, T | 1 |
| Shinpo, H | 1 |
| Mizumoto, T | 1 |
| Shimono, T | 1 |
| Shikano, K | 1 |
| Takeuchi, Y | 1 |
| Tanaka, K | 1 |
| Yada, K | 1 |
| Yuasa, H | 1 |
| Kusagawa, M | 1 |
| Kittaka, M | 1 |
| Giannotta, SL | 1 |
| Zelman, V | 1 |
| Correale, JD | 1 |
| DeGiorgio, CM | 1 |
| Weiss, MH | 1 |
| Zlokovic, BV | 1 |
| Funato, H | 1 |
| Kawano, H | 1 |
| Akada, Y | 1 |
| Katsuki, Y | 1 |
| Sato, M | 1 |
| Uemura, A | 1 |
| Meschia, JF | 1 |
| Malkoff, MD | 1 |
| Biller, J | 1 |
| Miyazaki, H | 1 |
| Tanaka, S | 1 |
| Fujii, Y | 1 |
| Shimizu, K | 1 |
| Nagashima, K | 1 |
| Kamibayashi, M | 1 |
| Uehara, T | 1 |
| Okuma, Y | 1 |
| Nomura, Y | 1 |
| Mikami, C | 1 |
| Suzuki, M | 1 |
| Tsuiki, K | 1 |
| Ogawa, A | 1 |
| Shirakura, S | 1 |
| Sano, J | 1 |
| Karasawa, A | 1 |
| Kubo, K | 1 |
| Takakura, S | 1 |
| Susumu, T | 2 |
| Satoh, H | 1 |
| Mori, J | 1 |
| Shiino, A | 2 |
| Handa, J | 2 |
| Matsuda, M | 1 |
| Morikawa, S | 1 |
| Kido, C | 1 |
| Inubushi, T | 1 |
| Adams, HP | 1 |
| Yao, LP | 1 |
| Ding, DY | 1 |
4 reviews available for nicardipine and Cerebral Infarction
| Article | Year |
|---|---|
Lessons Learned from Phase II and Phase III Trials Investigating Therapeutic Agents for Cerebral Ischemia Associated with Aneurysmal Subarachnoid Hemorrhage.
Topics: Brain Ischemia; Cerebral Infarction; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III | 2022 |
Cerebral vasospasm.
Topics: Aneurysm, Ruptured; Blood Pressure; Blood Volume; Brain Ischemia; Catheterization; Cerebral Infarcti | 1993 |
Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin.
Topics: Acetaminophen; Adult; Antipyrine; Cerebral Infarction; Chloral Hydrate; Drug Combinations; Drug Ther | 1998 |
Calcium antagonists in the management of patients with aneurysmal subarachnoid hemorrhage: a review.
Topics: Calcium Channel Blockers; Cerebral Infarction; Humans; Intracranial Aneurysm; Ischemic Attack, Trans | 1990 |
1 trial available for nicardipine and Cerebral Infarction
| Article | Year |
|---|---|
Calcium antagonists in the management of patients with aneurysmal subarachnoid hemorrhage: a review.
Topics: Calcium Channel Blockers; Cerebral Infarction; Humans; Intracranial Aneurysm; Ischemic Attack, Trans | 1990 |
13 other studies available for nicardipine and Cerebral Infarction
| Article | Year |
|---|---|
Twelve-year single critical care center experience of nicardipine prolonged-release implants in patients with subarachnoid hemorrhage: a propensity score matching analysis.
Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Critical Care; Female; Humans; Male; Middle Age | 2020 |
Endovascular management of cerebral vasospasm following aneurysm rupture: outcomes and predictors in 116 patients.
Topics: Adult; Aged; Angioplasty, Balloon; Calcium Channel Blockers; Cerebral Infarction; Combined Modality | 2014 |
Use of a calcium channel blocker (nicardipine HCl) in the treatment of childhood moyamoya disease.
Topics: Carotid Stenosis; Cerebral Angiography; Cerebral Infarction; Cerebral Revascularization; Child; Comb | 1994 |
Effects of dihydropyridines on cerebral blood vessels.
Topics: Administration, Oral; Blood Pressure; Cerebral Infarction; Cerebrovascular Circulation; Cerebrovascu | 1993 |
[Selective cerebral perfusion and pharmacological cerebral protection in the patients with aortic arch aneurysm].
Topics: Adult; Aged; Aged, 80 and over; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Aortic Dissection; Blood | 1993 |
Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model.
Topics: Animals; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; Ischemic Attack, | 1997 |
Effects of a calcium antagonist, lacidipine, on experimental focal cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Brain; Calcium Channel Blockers; Cerebral Arterial Diseases; Cerebr | 1997 |
Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury.
Topics: Animals; Body Temperature; Brain Edema; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Prote | 1999 |
Effect of nicardipine and magnesiumon cerebral infarction - brain surface perfusion technique.
Topics: Administration, Topical; Animals; Brain; Calcium Channel Blockers; Cerebral Infarction; Drug Combina | 2001 |
Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats.
Topics: Animals; Arachidonic Acid; Benzoquinones; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Calcium | 1992 |
Nilvadipine, a new calcium channel blocker, reduces ischemic brain injury in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Nicardipine; Nifedipine; Rat | 1991 |
[Ca++ antagonist and acute brain ischemia: effects of nilvadipine and nicardipine on middle cerebral artery occlusion in rats].
Topics: Acute Disease; Animals; Calcium Channel Blockers; Cerebral Infarction; Constriction; Ischemic Attack | 1991 |
Effect of nicardipine on somatosensory evoked potentials in patients with acute cerebral infarction.
Topics: Administration, Oral; Aged; Blood Pressure; Cerebral Infarction; Electroencephalography; Evoked Pote | 1990 |