nicardipine has been researched along with Cardiomegaly in 13 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of a sustained-release formulation of the calcium antagonist nicardipine on left ventricular (LV) mass, Doppler transmitral velocity profiles and plasma neurohumoral studies were analyzed in patients with mild to moderate systemic hypertension." | 9.07 | Effects of sustained-release nicardipine on regression of left ventricular hypertrophy in systemic hypertension. ( Adler, J; Dittrich, HC; Ong, J; Reitman, M; Weber, M; Ziegler, M, 1992) |
| "The present study was designed to investigate the effect of nicardipine administration upon systolic blood pressure (SBP) and cardiac hypertrophy in spontaneously hypertensive rats (SHR)." | 7.68 | Effect of nicardipine treatment upon cardiac hypertrophy in spontaneously hypertensive rats: a morphometric and ultrastructural study. ( Amenta, F; Bronzetti, E; Ciriaco, E; Felici, L; Ferrante, F, 1992) |
| "Nicardipine treatment allowed blood pressure control, reduction of left ventricular mass, and improvement in mechanical performance, but was unable to restore minimal coronary vascular resistance." | 5.28 | Nicardipine and cardiac hypertrophy: effects on left ventricular mass. Haemodynamics and mechanical performance in renovascular hypertensive rats. ( Besse, P; Bonoron-Adèle, S; Grellet, J; Stuyvers, B; Tariosse, L, 1991) |
| "The effects of a sustained-release formulation of the calcium antagonist nicardipine on left ventricular (LV) mass, Doppler transmitral velocity profiles and plasma neurohumoral studies were analyzed in patients with mild to moderate systemic hypertension." | 5.07 | Effects of sustained-release nicardipine on regression of left ventricular hypertrophy in systemic hypertension. ( Adler, J; Dittrich, HC; Ong, J; Reitman, M; Weber, M; Ziegler, M, 1992) |
| "The present study was designed to investigate the effect of nicardipine administration upon systolic blood pressure (SBP) and cardiac hypertrophy in spontaneously hypertensive rats (SHR)." | 3.68 | Effect of nicardipine treatment upon cardiac hypertrophy in spontaneously hypertensive rats: a morphometric and ultrastructural study. ( Amenta, F; Bronzetti, E; Ciriaco, E; Felici, L; Ferrante, F, 1992) |
| "To investigate the relationship between cardiac hypertrophy associated with hypertension, and the alterations in myocardial lipid metabolism, nicardipine (160 mg/kg/day), hydralazine (40 mg/kg/day), and enalapril (30 mg/kg/day) were administered to spontaneously hypertensive rats from 20 to 24 weeks of age." | 3.67 | Fatty acid binding protein of cardiac muscle in spontaneously hypertensive rats: effect of hypertrophy and its regression. ( Fujii, S; Kawaguchi, H; Okamoto, H; Saito, H; Togashi, H; Yasuda, H, 1988) |
| "Changes in hemodynamic variables regulating systolic function were assessed by M-mode echocardiography, under 2D control, in 11 patients with primary uncomplicated hypertension treated with nicardipine (60 mg/daily)." | 3.67 | [Echocardiographic analysis of anatomical and functional changes in the left heart ventricle during antihypertensive treatment with nicardipine]. ( Buonissimo, S; Costantino, G; De Simone, G; Di Lorenzo, L; Ferrara, LA; Moccia, D; Soro, S, 1988) |
| " Co-administration with propranolol markedly decreased the heart rate, but little affected the heart weight, suggesting changes in the heart rate during the long-term administration of KW-3049 did not largely affect cardiac hypertrophy." | 1.29 | Effect of the new calcium antagonist (+/-)-(R*)-3-[(R*)-1-benzyl-3- piperidyl] methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5- pyridinedicarboxylate hydrochloride (KW-3049) on cardiac hypertrophy in spontaneously hypertensive rats. ( Deguchi, T; Hara, T; Hattori, O; Kato, Y; Saijyo, T; Suzuki, K; Tanaka, H, 1993) |
| "Nicardipine treatment allowed blood pressure control, reduction of left ventricular mass, and improvement in mechanical performance, but was unable to restore minimal coronary vascular resistance." | 1.28 | Nicardipine and cardiac hypertrophy: effects on left ventricular mass. Haemodynamics and mechanical performance in renovascular hypertensive rats. ( Besse, P; Bonoron-Adèle, S; Grellet, J; Stuyvers, B; Tariosse, L, 1991) |
| "Nicardipine treatment (10 to 15 mg intraperitoneal dosage during 8 weeks), led to: an efficient but incomplete control of hypertension." | 1.27 | [Effects of nicardipine on left ventricular hypertrophy of the rat with renovascular arterial hypertension]. ( Besse, P; Bonoron-Adèle, S; Grellet, J; Stuyvers, B; Tariosse, L, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giudicelli, JF | 1 |
| Freslon, JL | 1 |
| Richer, C | 1 |
| Kato, Y | 1 |
| Tanaka, H | 1 |
| Saijyo, T | 1 |
| Hattori, O | 1 |
| Suzuki, K | 1 |
| Hara, T | 1 |
| Deguchi, T | 1 |
| Kobori, H | 1 |
| Ichihara, A | 1 |
| Suzuki, H | 1 |
| Takenaka, T | 1 |
| Miyashita, Y | 1 |
| Hayashi, M | 1 |
| Saruta, T | 1 |
| Huang, CY | 1 |
| Hao, LY | 1 |
| Buetow, DE | 1 |
| Ferrante, F | 1 |
| Bronzetti, E | 1 |
| Ciriaco, E | 1 |
| Felici, L | 1 |
| Amenta, F | 1 |
| Dittrich, HC | 1 |
| Adler, J | 1 |
| Ong, J | 1 |
| Reitman, M | 1 |
| Weber, M | 1 |
| Ziegler, M | 1 |
| Grellet, J | 2 |
| Bonoron-Adèle, S | 2 |
| Stuyvers, B | 2 |
| Tariosse, L | 2 |
| Besse, P | 2 |
| de Simone, G | 2 |
| Costantino, G | 2 |
| Soro, S | 2 |
| Di Lorenzo, L | 2 |
| Moccia, D | 2 |
| Buonissimo, S | 2 |
| Ferrara, LA | 2 |
| Gosse, P | 1 |
| Lacroix, P | 1 |
| Roudaut, R | 1 |
| Dallocchio, M | 1 |
| Fujii, S | 1 |
| Kawaguchi, H | 1 |
| Okamoto, H | 1 |
| Saito, H | 1 |
| Togashi, H | 1 |
| Yasuda, H | 1 |
| Bélichard, P | 1 |
| Pruneau, D | 1 |
| Rochette, L | 1 |
3 trials available for nicardipine and Cardiomegaly
| Article | Year |
|---|---|
Effects of sustained-release nicardipine on regression of left ventricular hypertrophy in systemic hypertension.
Topics: Aldosterone; Blood Pressure; Cardiomegaly; Delayed-Action Preparations; Double-Blind Method; Echocar | 1992 |
Effects of nicardipine on left ventricular hemodynamic patterns in systemic hypertension.
Topics: Adult; Blood Pressure; Cardiomegaly; Double-Blind Method; Echocardiography; Female; Humans; Hyperten | 1989 |
Left ventricular mass changes with nicardipine therapy in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Echocardiography; Female; Heart Ventricles; Humans; Hyper | 1989 |
10 other studies available for nicardipine and Cardiomegaly
| Article | Year |
|---|---|
[Antihypertensives and the prevention of development of genetic hypertension in the hypertensive SHR rat].
Topics: Animals; Antihypertensive Agents; Atenolol; Captopril; Cardiomegaly; Dihydralazine; Dose-Response Re | 1980 |
Effect of the new calcium antagonist (+/-)-(R*)-3-[(R*)-1-benzyl-3- piperidyl] methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5- pyridinedicarboxylate hydrochloride (KW-3049) on cardiac hypertrophy in spontaneously hypertensive rats.
Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiomegal | 1993 |
Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism.
Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Blood; Cardiomegaly; Hemodynamics; Hyperthyroi | 1997 |
Insulin-like growth factor-induced hypertrophy of cultured adult rat cardiomyocytes is L-type calcium-channel-dependent.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cardiac Myosins; Cardiomegaly; Cell Siz | 2002 |
Effect of nicardipine treatment upon cardiac hypertrophy in spontaneously hypertensive rats: a morphometric and ultrastructural study.
Topics: Animals; Cardiomegaly; Drug Evaluation, Preclinical; Hydralazine; Hypertension; Male; Microscopy, El | 1992 |
Nicardipine and cardiac hypertrophy: effects on left ventricular mass. Haemodynamics and mechanical performance in renovascular hypertensive rats.
Topics: Animals; Cardiomegaly; Hemodynamics; Hypertension, Renovascular; Male; Myocardial Contraction; Nephr | 1991 |
Fatty acid binding protein of cardiac muscle in spontaneously hypertensive rats: effect of hypertrophy and its regression.
Topics: Animals; Blood Pressure; Cardiomegaly; Carrier Proteins; Enalapril; Fatty Acid-Binding Protein 7; Fa | 1988 |
[Arterial hypertension, myocardial hypertrophy and disorders of cardiac rhythm induced by ligation of the left coronary artery in the rat].
Topics: Animals; Cardiomegaly; Coronary Disease; Coronary Vessels; Hypertension; Ligation; Male; Nicardipine | 1987 |
[Effects of nicardipine on left ventricular hypertrophy of the rat with renovascular arterial hypertension].
Topics: Animals; Cardiomegaly; Coronary Circulation; Hemodynamics; Hypertension, Renovascular; Male; Myocard | 1988 |
[Echocardiographic analysis of anatomical and functional changes in the left heart ventricle during antihypertensive treatment with nicardipine].
Topics: Adult; Blood Pressure; Cardiomegaly; Drug Evaluation; Echocardiography; Female; Heart; Hemodynamics; | 1988 |